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Amanda C. Poholek, Ph.D. - Publications

Affiliations: 
2009 Yale University, New Haven, CT 
Area:
Immunology
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ford BR, Poholek AC. Regulation and Immunotherapeutic Targeting of the Epigenome in Exhausted CD8 T Cell Responses. Journal of Immunology (Baltimore, Md. : 1950). 210: 869-879. PMID 36947818 DOI: 10.4049/jimmunol.2200681  0.406
2022 Vignali PDA, DePeaux K, Watson MJ, Ye C, Ford BR, Lontos K, McGaa NK, Scharping NE, Menk AV, Robson SC, Poholek AC, Rivadeneira DB, Delgoffe GM. Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity. Nature Immunology. PMID 36543958 DOI: 10.1038/s41590-022-01379-9  0.525
2022 Ford BR, Vignali PDA, Rittenhouse NL, Scharping NE, Peralta R, Lontos K, Frisch AT, Delgoffe GM, Poholek AC. Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells. Science Immunology. 7: eabj9123. PMID 35930654 DOI: 10.1126/sciimmunol.abj9123  0.447
2022 Dwyer GK, Mathews LR, Villegas JA, Lucas A, Gonzalez de Peredo A, Blazar BR, Girard JP, Poholek AC, Luther SA, Shlomchik W, Turnquist HR. IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease. The Journal of Clinical Investigation. PMID 35503257 DOI: 10.1172/JCI150927  0.548
2022 Poholek AC. CAR T cells are in it [CD]4 the long haul. Cell. 185: 1112-1114. PMID 35364030 DOI: 10.1016/j.cell.2022.03.004  0.515
2021 Poholek AC. Tissue-Specific Contributions to Control of T Cell Immunity. Immunohorizons. 5: 410-423. PMID 34103371 DOI: 10.4049/immunohorizons.2000103  0.47
2021 Watson MJ, Vignali PDA, Mullett SJ, Overacre-Delgoffe AE, Peralta RM, Grebinoski S, Menk AV, Rittenhouse NL, DePeaux K, Whetstone RD, Vignali DAA, Hand TW, Poholek AC, Morrison BM, Rothstein JD, et al. Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. Nature. PMID 33589820 DOI: 10.1038/s41586-020-03045-2  0.575
2021 Scharping NE, Rivadeneira DB, Menk AV, Vignali PDA, Ford BR, Rittenhouse NL, Peralta R, Wang Y, Wang Y, DePeaux K, Poholek AC, Delgoffe GM. Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nature Immunology. PMID 33398183 DOI: 10.1038/s41590-020-00834-9  0.546
2020 Poholek CH, Raphael I, Wu D, Revu S, Rittenhouse N, Uche UU, Majumder S, Kane LP, Poholek AC, McGeachy MJ. Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen. The Journal of Experimental Medicine. 217. PMID 32697822 DOI: 10.1084/Jem.20191761  0.514
2020 He K, Hettinga A, Kale SL, Hu S, Xie MM, Dent AL, Ray A, Poholek AC. Blimp-1 is essential for allergen-induced asthma and Th2 cell development in the lung. The Journal of Experimental Medicine. 217. PMID 32399548 DOI: 10.1084/Jem.20190742  0.489
2019 Ren Q, Gliozzi ML, Rittenhouse NL, Edmunds LR, Rbaibi Y, Locker JD, Poholek AC, Jurczak MJ, Baty CJ, Weisz OA. Shear stress and oxygen availability drive differential changes in OK proximal tubule cell metabolism and endocytosis. Traffic (Copenhagen, Denmark). PMID 30989771 DOI: 10.1111/Tra.12648  0.335
2019 Majumder S, Amatya N, Revu S, Jawale CV, Wu D, Rittenhouse N, Menk A, Kupul S, Du F, Raphael I, Bhattacharjee A, Siebenlist U, Hand TW, Delgoffe GM, Poholek AC, et al. IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival. Nature Immunology. PMID 30962593 DOI: 10.1038/S41590-019-0367-4  0.624
2019 Sawant DV, Yano H, Chikina M, Zhang Q, Liao M, Liu C, Callahan DJ, Sun Z, Sun T, Tabib T, Pennathur A, Corry DB, Luketich JD, Lafyatis R, Chen W, ... Poholek AC, et al. Adaptive plasticity of IL-10 and IL-35 T cells cooperatively promotes tumor T cell exhaustion. Nature Immunology. PMID 30936494 DOI: 10.1038/S41590-019-0346-9  0.636
2018 Revu S, Wu J, Henkel M, Rittenhouse N, Menk A, Delgoffe GM, Poholek AC, McGeachy MJ. IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation. Cell Reports. 22: 2642-2653. PMID 29514093 DOI: 10.1016/J.Celrep.2018.02.044  0.507
2017 Simpson-Abelson MR, Hernandez-Mir G, Childs EE, Cruz JA, Poholek AC, Chattopadhyay A, Gaffen SL, McGeachy MJ. CCAAT/Enhancer-binding protein β promotes pathogenesis of EAE. Cytokine. 92: 24-32. PMID 28088614 DOI: 10.1016/J.Cyto.2017.01.005  0.45
2016 Poholek AC, Jankovic D, Villarino AV, Petermann F, Hettinga A, Shouval DS, Snapper SB, Kaech SM, Brooks SR, Vahedi G, Sher A, Kanno Y, O'Shea JJ. IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. Science Immunology. 1. PMID 28713870 DOI: 10.1126/Sciimmunol.Aaf8612  0.692
2014 Shih HY, Sciumè G, Poholek AC, Vahedi G, Hirahara K, Villarino AV, Bonelli M, Bosselut R, Kanno Y, Muljo SA, O'Shea JJ. Transcriptional and epigenetic networks of helper T and innate lymphoid cells. Immunological Reviews. 261: 23-49. PMID 25123275 DOI: 10.1111/Imr.12208  0.677
2014 Bonelli M, Shih HY, Hirahara K, Singelton K, Laurence A, Poholek A, Hand T, Mikami Y, Vahedi G, Kanno Y, O'Shea JJ. Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. Current Topics in Microbiology and Immunology. 381: 279-326. PMID 24831346 DOI: 10.1007/82_2014_371  0.643
2014 Weinstein JS, Bertino SA, Hernandez SG, Poholek AC, Teplitzky TB, Nowyhed HN, Craft J. B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen. Journal of Immunology (Baltimore, Md. : 1950). 192: 3166-79. PMID 24610013 DOI: 10.4049/Jimmunol.1302617  0.766
2014 Nakayamada S, Poholek AC, Lu KT, Takahashi H, Kato M, Iwata S, Hirahara K, Cannons JL, Schwartzberg PL, Vahedi G, Sun HW, Kanno Y, O'Shea JJ. Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program. Journal of Immunology (Baltimore, Md. : 1950). 192: 2156-66. PMID 24489092 DOI: 10.4049/Jimmunol.1300675  0.581
2013 Hirahara K, Poholek A, Vahedi G, Laurence A, Kanno Y, Milner JD, O'Shea JJ. Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease. The Journal of Allergy and Clinical Immunology. 131: 1276-87. PMID 23622118 DOI: 10.1016/J.Jaci.2013.03.015  0.651
2012 Sciumé G, Hirahara K, Takahashi H, Laurence A, Villarino AV, Singleton KL, Spencer SP, Wilhelm C, Poholek AC, Vahedi G, Kanno Y, Belkaid Y, O'Shea JJ. Distinct requirements for T-bet in gut innate lymphoid cells. The Journal of Experimental Medicine. 209: 2331-8. PMID 23209316 DOI: 10.1084/Jem.20122097  0.67
2012 Petrovas C, Yamamoto T, Gerner MY, Boswell KL, Wloka K, Smith EC, Ambrozak DR, Sandler NG, Timmer KJ, Sun X, Pan L, Poholek A, Rao SS, Brenchley JM, Alam SM, et al. CD4 T follicular helper cell dynamics during SIV infection. The Journal of Clinical Investigation. 122: 3281-94. PMID 22922258 DOI: 10.1172/Jci63039  0.625
2012 Poholek A, Choi J, Hernandez S, Weinstein J, Kim S, Bunin V, Odegard J, DiPlacido L, Craft J. Follicular helper T Cells and the B cells they help Arthritis Research & Therapy. 14. DOI: 10.1186/Ar3936  0.738
2011 Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM. Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. Immunity. 35: 633-46. PMID 22018471 DOI: 10.1016/J.Immuni.2011.08.016  0.728
2010 Poholek AC, Hansen K, Hernandez SG, Eto D, Chandele A, Weinstein JS, Dong X, Odegard JM, Kaech SM, Dent AL, Crotty S, Craft J. In vivo regulation of Bcl6 and T follicular helper cell development. Journal of Immunology (Baltimore, Md. : 1950). 185: 313-26. PMID 20519643 DOI: 10.4049/Jimmunol.0904023  0.82
2010 Marks BR, Nowyhed HN, Choi J, Poholek AC, Odegard JM, Flavell RA, Craft J. Erratum: Corrigendum: Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation Nature Immunology. 11: 97-97. DOI: 10.1038/Ni0110-97B  0.71
2009 Marks BR, Nowyhed HN, Choi JY, Poholek AC, Odegard JM, Flavell RA, Craft J. Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. Nature Immunology. 10: 1125-32. PMID 19734905 DOI: 10.1038/Ni.1783  0.763
2009 Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (New York, N.Y.). 325: 1006-10. PMID 19608860 DOI: 10.1126/Science.1175870  0.803
2009 Poholek AC, Craft J. Competing for help: new insights into the function of follicular helper T cells. Immunology and Cell Biology. 87: 438-9. PMID 19381158 DOI: 10.1038/Icb.2009.26  0.763
2008 Odegard JM, Marks BR, DiPlacido LD, Poholek AC, Kono DH, Dong C, Flavell RA, Craft J. ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. The Journal of Experimental Medicine. 205: 2873-86. PMID 18981236 DOI: 10.1084/Jem.20080840  0.746
2006 Boyd KE, Xiao YY, Fan K, Poholek A, Copeland NG, Jenkins NA, Perkins AS. Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR. Blood. 107: 733-41. PMID 16204320 DOI: 10.1182/Blood-2003-05-1626  0.35
2005 Ramsburg E, Publicover J, Buonocore L, Poholek A, Robek M, Palin A, Rose JK. A vesicular stomatitis virus recombinant expressing granulocyte-macrophage colony-stimulating factor induces enhanced T-cell responses and is highly attenuated for replication in animals. Journal of Virology. 79: 15043-53. PMID 16306575 DOI: 10.1128/Jvi.79.24.15043-15053.2005  0.395
2005 Yatsula B, Lin S, Read AJ, Poholek A, Yates K, Yue D, Hui P, Perkins AS. Identification of binding sites of EVI1 in mammalian cells. The Journal of Biological Chemistry. 280: 30712-22. PMID 16006653 DOI: 10.1074/Jbc.M504293200  0.316
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