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Stephen J. Benkovic - Publications

Affiliations: 
Pennsylvania State University, State College, PA, United States 
Area:
mechanistic enzymology
Website:
https://science.psu.edu/chem/people/sjb1
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Year Citation  Score
2020 Doigneaux C, Pedley AM, Mistry IN, Papayova M, Benkovic SJ, Tavassoli A. Hypoxia Drives the Assembly of the Multi-Enzyme Purinosome Complex. The Journal of Biological Chemistry. PMID 32439803 DOI: 10.1074/Jbc.Ra119.012175  0.31
2019 Benkovic SJ. Thomas Bruice (1925-2019). Proceedings of the National Academy of Sciences of the United States of America. PMID 31636196 DOI: 10.1073/Pnas.1913522116  0.317
2019 Perumal SK, Xu X, Yan C, Ivanov I, Benkovic SJ. Recognition of a Key Anchor Residue by a Conserved Hydrophobic Pocket Ensures Subunit Interface Integrity in DNA Clamps. Journal of Molecular Biology. PMID 31051173 DOI: 10.1016/J.Jmb.2019.04.035  0.348
2019 Liu C, Knudsen GM, Pedley AM, He J, Johnson JL, Yaron TM, Cantley LC, Benkovic SJ. Mapping post-translational modifications of de novo purine biosynthetic enzymes: Implications for pathway regulation. Journal of Proteome Research. PMID 30964683 DOI: 10.1021/Acs.Jproteome.8B00969  0.344
2019 Hedglin M, Aitha M, Pedley A, Benkovic SJ. Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen. The Journal of Biological Chemistry. PMID 30700555 DOI: 10.1074/Jbc.Ra118.005297  0.352
2018 Pedley AM, Benkovic SJ. Detecting Purinosome Metabolon Formation with Fluorescence Microscopy. Methods in Molecular Biology (Clifton, N.J.). 1764: 279-289. PMID 29605921 DOI: 10.1007/978-1-4939-7759-8_17  0.321
2018 Pedley AM, Karras GI, Zhang X, Lindquist SL, Benkovic SJ. The Role of HSP90 in the Regulation of de novo Purine Biosynthesis. Biochemistry. PMID 29553718 DOI: 10.1021/Acs.Biochem.8B00140  0.331
2018 Zhao X, Palacci H, Yadav V, Spiering MM, Gilson MK, Butler PJ, Hess H, Benkovic SJ, Sen A. Substrate-driven chemotactic assembly in an enzyme cascade. Nature Chemistry. 10: 311-317. PMID 29461522 DOI: 10.1038/Nchem.2905  0.353
2017 Benkovic SJ, Spiering MM. Understanding DNA replication by the bacteriophage T4 replisome. The Journal of Biological Chemistry. PMID 28972188 DOI: 10.1074/Jbc.R117.811208  0.327
2017 Hedglin M, Aitha M, Benkovic SJ. Monitoring the Retention of Human PCNA at Primer/Template junctions by Proteins that Bind Single-stranded DNA. Biochemistry. PMID 28590137 DOI: 10.1021/Acs.Biochem.7B00386  0.346
2017 Spiering MM, Hanoian P, Gannavaram S, Benkovic SJ. RNA primer-primase complexes serve as the signal for polymerase recycling and Okazaki fragment initiation in T4 phage DNA replication. Proceedings of the National Academy of Sciences of the United States of America. PMID 28507156 DOI: 10.1073/Pnas.1620459114  0.337
2017 Hedglin M, Benkovic SJ. Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle. Chemical Reviews. PMID 28497687 DOI: 10.1021/Acs.Chemrev.7B00046  0.315
2017 Hedglin M, Benkovic SJ. Replication protein A prohibits diffusion of the PCNA sliding clamp along single-stranded DNA. Biochemistry. PMID 28177605 DOI: 10.1021/Acs.Biochem.6B01213  0.34
2016 Hedglin M, Pandey B, Benkovic SJ. Characterization of human translesion DNA synthesis across a UV-induced DNA lesion. Elife. 5. PMID 27770570 DOI: 10.7554/Elife.19788  0.319
2016 Hedglin M, Pandey B, Benkovic SJ. Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976599 DOI: 10.1073/Pnas.1523653113  0.326
2015 Choi JS, Dasari A, Hu P, Benkovic SJ, Berdis AJ. The use of modified and non-natural nucleotides provide unique insights into pro-mutagenic replication catalyzed by polymerase eta. Nucleic Acids Research. PMID 26717984 DOI: 10.1093/Nar/Gkv1509  0.33
2015 Talukder P, Chen S, Roy B, Yakovchuk P, Spiering MM, Alam MP, Mathilakathu Madathil M, Bhattacharya C, Benkovic SJ, Hecht SM. Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA-Protein Interaction. Biochemistry. PMID 26618501 DOI: 10.1021/Acs.Biochem.5B01085  0.349
2015 Moree B, Connell K, Mortensen RB, Liu CT, Benkovic SJ, Salafsky J. Protein Conformational Changes Are Detected and Resolved Site Specifically by Second-Harmonic Generation. Biophysical Journal. 109: 806-15. PMID 26287632 DOI: 10.1016/J.Bpj.2015.07.016  0.303
2015 Noble E, Spiering MM, Benkovic SJ. Coordinated DNA Replication by the Bacteriophage T4 Replisome. Viruses. 7: 3186-200. PMID 26102578 DOI: 10.3390/V7062766  0.36
2015 Hedglin M, Benkovic SJ. Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance. Annual Review of Biophysics. 44: 207-28. PMID 26098514 DOI: 10.1146/Annurev-Biophys-060414-033841  0.316
2015 Zhao H, Chiaro CR, Zhang L, Smith PB, Chan CY, Pedley AM, Pugh RJ, French JB, Patterson AD, Benkovic SJ. Quantitative analysis of purine nucleotides indicates that purinosomes increase de novo purine biosynthesis. The Journal of Biological Chemistry. 290: 6705-13. PMID 25605736 DOI: 10.1074/Jbc.M114.628701  0.324
2015 Hanoian P, Liu CT, Hammes-Schiffer S, Benkovic S. Perspectives on electrostatics and conformational motions in enzyme catalysis. Accounts of Chemical Research. 48: 482-9. PMID 25565178 DOI: 10.1021/Ar500390E  0.366
2015 Tony Liu C, Tomsho JW, Benkovic SJ. Corrigendum to "The unique chemistry of benzoxaboroles: Current and emerging applications in biotechnology and therapeutic treatments" [Bioorg. Med. Chem. 22 (2014) 4462-4473] Bioorganic and Medicinal Chemistry. DOI: 10.1016/J.Bmc.2015.04.043  0.709
2014 Liu CT, Francis K, Layfield JP, Huang X, Hammes-Schiffer S, Kohen A, Benkovic SJ. Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: temporal order and the roles of Asp27 and Tyr100. Proceedings of the National Academy of Sciences of the United States of America. 111: 18231-6. PMID 25453098 DOI: 10.1073/Pnas.1415940111  0.358
2014 Talukder P, Chen S, Liu CT, Baldwin EA, Benkovic SJ, Hecht SM. Tryptophan-based fluorophores for studying protein conformational changes. Bioorganic & Medicinal Chemistry. 22: 5924-34. PMID 25284250 DOI: 10.1016/J.Bmc.2014.09.015  0.326
2014 Liu CT, Layfield JP, Stewart RJ, French JB, Hanoian P, Asbury JB, Hammes-Schiffer S, Benkovic SJ. Probing the electrostatics of active site microenvironments along the catalytic cycle for Escherichia coli dihydrofolate reductase. Journal of the American Chemical Society. 136: 10349-60. PMID 24977791 DOI: 10.1021/Ja5038947  0.343
2014 Liu CT, Tomsho JW, Benkovic SJ. The unique chemistry of benzoxaboroles: current and emerging applications in biotechnology and therapeutic treatments. Bioorganic & Medicinal Chemistry. 22: 4462-73. PMID 24864040 DOI: 10.1016/J.Bmc.2014.04.065  0.722
2014 Sengupta S, Spiering MM, Dey KK, Duan W, Patra D, Butler PJ, Astumian RD, Benkovic SJ, Sen A. DNA polymerase as a molecular motor and pump. Acs Nano. 8: 2410-8. PMID 24601532 DOI: 10.1021/Nn405963X  0.321
2013 van Dongen SF, Clerx J, Nørgaard K, Bloemberg TG, Cornelissen JJ, Trakselis MA, Nelson SW, Benkovic SJ, Rowan AE, Nolte RJ. A clamp-like biohybrid catalyst for DNA oxidation. Nature Chemistry. 5: 945-51. PMID 24153373 DOI: 10.1038/Nchem.1752  0.702
2013 Chen S, Fahmi NE, Bhattacharya C, Wang L, Jin Y, Benkovic SJ, Hecht SM. Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification. Biochemistry. 52: 8580-9. PMID 24152169 DOI: 10.1021/Bi401275V  0.35
2013 Liu CT, Benkovic SJ. Capturing a sulfenic acid with arylboronic acids and benzoxaborole. Journal of the American Chemical Society. 135: 14544-7. PMID 24050501 DOI: 10.1021/Ja407628A  0.324
2013 Manosas M, Perumal SK, Bianco PR, Bianco P, Ritort F, Benkovic SJ, Croquette V. RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue. Nature Communications. 4: 2368. PMID 24013402 DOI: 10.1038/Ncomms3368  0.359
2013 Chen S, Fahmi NE, Wang L, Bhattacharya C, Benkovic SJ, Hecht SM. Detection of dihydrofolate reductase conformational change by FRET using two fluorescent amino acids. Journal of the American Chemical Society. 135: 12924-7. PMID 23941571 DOI: 10.1021/Ja403007R  0.326
2013 Boehr DD, Schnell JR, McElheny D, Bae SH, Duggan BM, Benkovic SJ, Dyson HJ, Wright PE. A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase. Biochemistry. 52: 4605-19. PMID 23758161 DOI: 10.1021/Bi400563C  0.357
2013 Liu CT, Hanoian P, French JB, Pringle TH, Hammes-Schiffer S, Benkovic SJ. Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans. Proceedings of the National Academy of Sciences of the United States of America. 110: 10159-64. PMID 23733948 DOI: 10.1073/Pnas.1307130110  0.354
2013 Perumal SK, Nelson SW, Benkovic SJ. Interaction of T4 UvsW helicase and single-stranded DNA binding protein gp32 through its carboxy-terminal acidic tail. Journal of Molecular Biology. 425: 2823-39. PMID 23732982 DOI: 10.1016/J.Jmb.2013.05.012  0.518
2013 Chen D, Yue H, Spiering MM, Benkovic SJ. Insights into Okazaki fragment synthesis by the T4 replisome: the fate of lagging-strand holoenzyme components and their influence on Okazaki fragment size. The Journal of Biological Chemistry. 288: 20807-16. PMID 23729670 DOI: 10.1074/Jbc.M113.485961  0.336
2013 Hedglin M, Perumal SK, Hu Z, Benkovic S. Stepwise assembly of the human replicative polymerase holoenzyme. Elife. 2: e00278. PMID 23577232 DOI: 10.7554/Elife.00278  0.325
2013 Hedglin M, Kumar R, Benkovic SJ. Replication clamps and clamp loaders. Cold Spring Harbor Perspectives in Biology. 5: a010165. PMID 23545418 DOI: 10.1101/Cshperspect.A010165  0.347
2013 French JB, Zhao H, An S, Niessen S, Deng Y, Cravatt BF, Benkovic SJ. Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome. Proceedings of the National Academy of Sciences of the United States of America. 110: 2528-33. PMID 23359685 DOI: 10.1073/Pnas.1300173110  0.71
2013 Perumal SK, Ren W, Lee TH, Benkovic SJ. How a holoenzyme for DNA replication is formed. Proceedings of the National Academy of Sciences of the United States of America. 110: 99-104. PMID 23248268 DOI: 10.1073/Pnas.1212748110  0.322
2013 Croquette V, Manosas M, Perumal SK, Benkovic SJ. Direct Observation of Stalled Fork Restart and Lesion Bypass via Fork Regression in the T4 Replication System Biophysical Journal. 104: 367a-368a. DOI: 10.1016/J.Bpj.2012.11.2042  0.304
2012 Tomsho JW, Pal A, Hall DG, Benkovic SJ. Ring Structure and Aromatic Substituent Effects on the pK a of the Benzoxaborole Pharmacophore. Acs Medicinal Chemistry Letters. 3: 48-52. PMID 24900370 DOI: 10.1021/Ml200215J  0.738
2012 Manosas M, Perumal SK, Croquette V, Benkovic SJ. Direct observation of stalled fork restart via fork regression in the T4 replication system. Science (New York, N.Y.). 338: 1217-20. PMID 23197534 DOI: 10.1126/Science.1225437  0.315
2012 Tomsho JW, Benkovic SJ. Examination of the reactivity of benzoxaboroles and related compounds with a cis-diol. The Journal of Organic Chemistry. 77: 11200-9. PMID 23116424 DOI: 10.1021/Jo302264G  0.744
2012 Chen S, Wang L, Fahmi NE, Benkovic SJ, Hecht SM. Two pyrenylalanines in dihydrofolate reductase form an excimer enabling the study of protein dynamics. Journal of the American Chemical Society. 134: 18883-5. PMID 23116258 DOI: 10.1021/Ja307179Q  0.347
2012 Deng Y, Gam J, French JB, Zhao H, An S, Benkovic SJ. Mapping protein-protein proximity in the purinosome. The Journal of Biological Chemistry. 287: 36201-7. PMID 22955281 DOI: 10.1074/Jbc.M112.407056  0.733
2012 Hu Z, Perumal SK, Yue H, Benkovic SJ. The human lagging strand DNA polymerase δ holoenzyme is distributive. The Journal of Biological Chemistry. 287: 38442-8. PMID 22942285 DOI: 10.1074/Jbc.M112.404319  0.355
2012 Spurr IB, Birts CN, Cuda F, Benkovic SJ, Blaydes JP, Tavassoli A. Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization. Chembiochem : a European Journal of Chemical Biology. 13: 1628-34. PMID 22764122 DOI: 10.1002/Cbic.201200279  0.329
2012 Manosas M, Spiering MM, Ding F, Bensimon D, Allemand JF, Benkovic SJ, Croquette V. Mechanism of strand displacement synthesis by DNA replicative polymerases. Nucleic Acids Research. 40: 6174-86. PMID 22434889 DOI: 10.1093/Nar/Gks253  0.343
2012 Manosas M, Spiering MM, Ding F, Croquette V, Benkovic SJ. Collaborative coupling between polymerase and helicase for leading-strand synthesis. Nucleic Acids Research. 40: 6187-98. PMID 22434886 DOI: 10.1093/Nar/Gks254  0.35
2012 Tomsho JW, Benkovic SJ. Elucidation of the mechanism of the reaction between phenylboronic acid and a model diol, Alizarin Red S. The Journal of Organic Chemistry. 77: 2098-106. PMID 22283713 DOI: 10.1021/Jo202250D  0.747
2012 Stojkovi? V, Perissinotti LL, Willmer D, Benkovic SJ, Kohen A. Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction. Journal of the American Chemical Society. 134: 1738-45. PMID 22171795 DOI: 10.1021/Ja209425W  0.341
2011 Hammes GG, Benkovic SJ, Hammes-Schiffer S. Flexibility, diversity, and cooperativity: pillars of enzyme catalysis. Biochemistry. 50: 10422-30. PMID 22029278 DOI: 10.1021/Bi201486F  0.373
2011 Verrier F, An S, Ferrie AM, Sun H, Kyoung M, Deng H, Fang Y, Benkovic SJ. GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis. Nature Chemical Biology. 7: 909-15. PMID 22020552 DOI: 10.1038/Nchembio.690  0.695
2011 Baker SJ, Tomsho JW, Benkovic SJ. Boron-containing inhibitors of synthetases. Chemical Society Reviews. 40: 4279-85. PMID 21298158 DOI: 10.1039/C0Cs00131G  0.753
2011 Herdendorf TJ, Albrecht DW, Benkovic SJ, Nelson SW. Biochemical characterization of bacteriophage T4 Mre11-Rad50 complex. The Journal of Biological Chemistry. 286: 2382-92. PMID 21081488 DOI: 10.1074/Jbc.M110.178871  0.537
2011 Croquette V, Manosas M, Ding F, Spiering M, Benkovic S. Forward and Backward Motion of Replicative Polymerases and Their Coupling with the Helicase Biophysical Journal. 100: 523a. DOI: 10.1016/J.Bpj.2010.12.3055  0.325
2010 Kumar R, Nashine VC, Mishra PP, Benkovic SJ, Lee TH. Stepwise loading of yeast clamp revealed by ensemble and single-molecule studies. Proceedings of the National Academy of Sciences of the United States of America. 107: 19736-41. PMID 21041673 DOI: 10.1073/Pnas.1014139107  0.326
2010 Schaerli Y, Stein V, Spiering MM, Benkovic SJ, Abell C, Hollfelder F. Isothermal DNA amplification using the T4 replisome: circular nicking endonuclease-dependent amplification and primase-based whole-genome amplification. Nucleic Acids Research. 38: e201. PMID 20921065 DOI: 10.1093/Nar/Gkq795  0.512
2010 An S, Deng Y, Tomsho JW, Kyoung M, Benkovic SJ. Microtubule-assisted mechanism for functional metabolic macromolecular complex formation. Proceedings of the National Academy of Sciences of the United States of America. 107: 12872-6. PMID 20615962 DOI: 10.1073/Pnas.1008451107  0.767
2010 Nelson SW, Benkovic SJ. Response of the bacteriophage T4 replisome to noncoding lesions and regression of a stalled replication fork. Journal of Molecular Biology. 401: 743-56. PMID 20600127 DOI: 10.1016/J.Jmb.2010.06.027  0.475
2010 Perumal SK, Raney KD, Benkovic SJ. Analysis of the DNA translocation and unwinding activities of T4 phage helicases. Methods (San Diego, Calif.). 51: 277-88. PMID 20170733 DOI: 10.1016/J.Ymeth.2010.02.011  0.355
2010 An S, Kyoung M, Allen JJ, Shokat KM, Benkovic SJ. Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2. The Journal of Biological Chemistry. 285: 11093-9. PMID 20157113 DOI: 10.1074/Jbc.M110.101139  0.734
2010 Lee J, Yennawar NH, Gam J, Benkovic SJ. Kinetic and structural characterization of dihydrofolate reductase from Streptococcus pneumoniae. Biochemistry. 49: 195-206. PMID 19950924 DOI: 10.1021/Bi901614M  0.351
2010 Perumal SK, Yue H, Hu Z, Spiering MM, Benkovic SJ. Single-molecule studies of DNA replisome function. Biochimica Et Biophysica Acta. 1804: 1094-112. PMID 19665592 DOI: 10.1016/J.Bbapap.2009.07.022  0.331
2010 STEWART JD, LIOTTA LJ, BENKOVIC SJ. ChemInform Abstract: Reaction Mechanisms Displayed by Catalytic Antibodies Cheminform. 24: no-no. DOI: 10.1002/chin.199349320  0.704
2010 JANDA KD, ASHLEY JA, JONES TM, MCLEOD DA, SCHLOEDER DM, WEINHOUSE MI, LERNER RA, GIBBS RA, BENKOVIC PA, HILHORST R, BENKOVIC SJ. ChemInform Abstract: Catalytic Antibodies with Acyl-Transfer Capabilities: Mechanistic and Kinetic Investigations. Cheminform. 22: no-no. DOI: 10.1002/chin.199115055  0.524
2009 Manosas M, Spiering MM, Zhuang Z, Benkovic SJ, Croquette V. Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosome. Nature Chemical Biology. 5: 904-12. PMID 19838204 DOI: 10.1016/J.Bpj.2009.12.379  0.333
2009 Arumugam SR, Lee TH, Benkovic SJ. Investigation of stoichiometry of T4 bacteriophage helicase loader protein (gp59). The Journal of Biological Chemistry. 284: 29283-9. PMID 19700405 DOI: 10.1074/Jbc.M109.029926  0.33
2009 Li H, Fast W, Benkovic SJ. Structural and functional modularity of proteins in the de novo purine biosynthetic pathway. Protein Science : a Publication of the Protein Society. 18: 881-92. PMID 19384989 DOI: 10.1002/Pro.95  0.652
2009 Nelson SW, Perumal SK, Benkovic SJ. Processive and unidirectional translocation of monomeric UvsW helicase on single-stranded DNA. Biochemistry. 48: 1036-46. PMID 19154117 DOI: 10.1021/Bi801792Q  0.528
2009 Nelson SW, Zhuang Z, Spiering MM, Benkovic SJ. T4 phage replisome Viral Genome Replication. 337-364. DOI: 10.1007/b135974_16  0.328
2008 Spiering MM, Nelson SW, Benkovic SJ. Repetitive lagging strand DNA synthesis by the bacteriophage T4 replisome. Molecular Biosystems. 4: 1070-4. PMID 18931782 DOI: 10.1039/B812163J  0.501
2008 Goodey NM, Benkovic SJ. Allosteric regulation and catalysis emerge via a common route. Nature Chemical Biology. 4: 474-82. PMID 18641628 DOI: 10.1038/Nchembio.98  0.307
2008 Nelson SW, Kumar R, Benkovic SJ. RNA primer handoff in bacteriophage T4 DNA replication: the role of single-stranded DNA-binding protein and polymerase accessory proteins. The Journal of Biological Chemistry. 283: 22838-46. PMID 18511422 DOI: 10.1074/Jbc.M802762200  0.526
2008 An S, Kumar R, Sheets ED, Benkovic SJ. Reversible compartmentalization of de novo purine biosynthetic complexes in living cells. Science (New York, N.Y.). 320: 103-6. PMID 18388293 DOI: 10.1126/Science.1152241  0.737
2008 Zhuang Z, Johnson RE, Haracska L, Prakash L, Prakash S, Benkovic SJ. Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme. Proceedings of the National Academy of Sciences of the United States of America. 105: 5361-6. PMID 18385374 DOI: 10.1073/Pnas.0801310105  0.33
2008 Benkovic SJ, Hammes GG, Hammes-Schiffer S. Free-energy landscape of enzyme catalysis. Biochemistry. 47: 3317-21. PMID 18298083 DOI: 10.1021/Bi800049Z  0.31
2008 Tomsho JW, Benkovic SJ. Unnatural translation initiation. Acs Chemical Biology. 3: 87-8. PMID 18278847 DOI: 10.1021/Cb8000233  0.741
2007 Lionnet T, Spiering MM, Benkovic SJ, Bensimon D, Croquette V. Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism. Proceedings of the National Academy of Sciences of the United States of America. 104: 19790-5. PMID 18077411 DOI: 10.1073/Pnas.0709793104  0.355
2007 Cheng L, Naumann TA, Horswill AR, Hong SJ, Venters BJ, Tomsho JW, Benkovic SJ, Keiler KC. Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease. Protein Science : a Publication of the Protein Society. 16: 1535-42. PMID 17600141 DOI: 10.1110/Ps.072933007  0.779
2007 Rock FL, Mao W, Yaremchuk A, Tukalo M, Crépin T, Zhou H, Zhang YK, Hernandez V, Akama T, Baker SJ, Plattner JJ, Shapiro L, Martinis SA, Benkovic SJ, Cusack S, et al. An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science (New York, N.Y.). 316: 1759-61. PMID 17588934 DOI: 10.1126/Science.1142189  0.341
2007 Nelson SW, Benkovic SJ. The T4 phage UvsW protein contains both DNA unwinding and strand annealing activities. The Journal of Biological Chemistry. 282: 407-16. PMID 17092935 DOI: 10.1074/Jbc.M608153200  0.543
2006 Horswill AR, Benkovic SJ. Identifying small-molecule modulators of protein-protein interactions. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 19.15. PMID 18429304 DOI: 10.1002/0471140864.Ps1915S46  0.54
2006 Wang L, Goodey NM, Benkovic SJ, Kohen A. Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase. Proceedings of the National Academy of Sciences of the United States of America. 103: 15753-8. PMID 17032759 DOI: 10.1073/Pnas.0606976103  0.34
2006 Wang L, Goodey NM, Benkovic SJ, Kohen A. The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 361: 1307-15. PMID 16873118 DOI: 10.1098/Rstb.2006.1871  0.349
2006 Smiley RD, Zhuang Z, Benkovic SJ, Hammes GG. Single-molecule investigation of the T4 bacteriophage DNA polymerase holoenzyme: multiple pathways of holoenzyme formation. Biochemistry. 45: 7990-7. PMID 16800624 DOI: 10.1021/Bi0603322  0.356
2006 Zhuang Z, Berdis AJ, Benkovic SJ. An alternative clamp loading pathway via the T4 clamp loader gp44/62-DNA complex. Biochemistry. 45: 7976-89. PMID 16800623 DOI: 10.1021/Bi0601205  0.341
2006 Hammes-Schiffer S, Benkovic SJ. Relating protein motion to catalysis. Annual Review of Biochemistry. 75: 519-41. PMID 16756501 DOI: 10.1146/Annurev.Biochem.75.103004.142800  0.314
2006 Zhuang Z, Yoder BL, Burgers PM, Benkovic SJ. The structure of a ring-opened proliferating cell nuclear antigen-replication factor C complex revealed by fluorescence energy transfer. Proceedings of the National Academy of Sciences of the United States of America. 103: 2546-51. PMID 16476998 DOI: 10.1073/Pnas.0511263103  0.335
2006 Wang L, Tharp S, Selzer T, Benkovic SJ, Kohen A. Effects of a distal mutation on active site chemistry. Biochemistry. 45: 1383-92. PMID 16445280 DOI: 10.1021/Bi0518242  0.327
2006 Park HS, Nam SH, Lee JK, Yoon CN, Mannervik B, Benkovic SJ, Kim HS. Design and evolution of new catalytic activity with an existing protein scaffold. Science (New York, N.Y.). 311: 535-8. PMID 16439663 DOI: 10.1126/Science.1118953  0.336
2006 Yang J, Nelson SW, Benkovic SJ. The control mechanism for lagging strand polymerase recycling during bacteriophage T4 DNA replication. Molecular Cell. 21: 153-64. PMID 16427006 DOI: 10.1016/J.Molcel.2005.11.029  0.495
2006 Nelson SW, Yang J, Benkovic SJ. Site-directed mutations of T4 helicase loading protein (gp59) reveal multiple modes of DNA polymerase inhibition and the mechanism of unlocking by gp41 helicase. The Journal of Biological Chemistry. 281: 8697-706. PMID 16407253 DOI: 10.1074/Jbc.M512185200  0.521
2005 Antikainen NM, Smiley RD, Benkovic SJ, Hammes GG. Conformation coupled enzyme catalysis: single-molecule and transient kinetics investigation of dihydrofolate reductase. Biochemistry. 44: 16835-43. PMID 16363797 DOI: 10.1021/Bi051378I  0.34
2005 Benkovic SJ, Baker SJ, Alley MR, Woo YH, Zhang YK, Akama T, Mao W, Baboval J, Rajagopalan PT, Wall M, Kahng LS, Tavassoli A, Shapiro L. Identification of borinic esters as inhibitors of bacterial cell growth and bacterial methyltransferases, CcrM and MenH. Journal of Medicinal Chemistry. 48: 7468-76. PMID 16279806 DOI: 10.1021/Jm050676A  0.309
2005 Griswold KE, Kawarasaki Y, Ghoneim N, Benkovic SJ, Iverson BL, Georgiou G. Evolution of highly active enzymes by homology-independent recombination. Proceedings of the National Academy of Sciences of the United States of America. 102: 10082-7. PMID 16009931 DOI: 10.1073/Pnas.0504556102  0.373
2005 Xi J, Zhang Z, Zhuang Z, Yang J, Spiering MM, Hammes GG, Benkovic SJ. Interaction between the T4 helicase loading protein (gp59) and the DNA polymerase (gp43): unlocking of the gp59-gp43-DNA complex to initiate assembly of a fully functional replisome. Biochemistry. 44: 7747-56. PMID 15909989 DOI: 10.1021/Bi047296W  0.332
2005 Yang J, Xi J, Zhuang Z, Benkovic SJ. The oligomeric T4 primase is the functional form during replication. The Journal of Biological Chemistry. 280: 25416-23. PMID 15897200 DOI: 10.1074/Jbc.M501847200  0.362
2005 Horswill AR, Benkovic SJ. Cyclic peptides, a chemical genetics tool for biologists. Cell Cycle (Georgetown, Tex.). 4: 552-5. PMID 15876867 DOI: 10.4161/Cc.4.4.1585  0.522
2005 Cheng H, Hwang I, Chong Y, Tavassoli A, Webb ME, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway. Bioorganic & Medicinal Chemistry. 13: 3593-9. PMID 15848772 DOI: 10.1016/J.Bmc.2004.11.049  0.542
2005 Woo YH, Rajagopalan PT, Benkovic SJ. A nonradioactive DNA methyltransferase assay adaptable to high-throughput screening. Analytical Biochemistry. 340: 336-40. PMID 15840507 DOI: 10.1016/J.Ab.2005.01.059  0.332
2005 Norcum MT, Warrington JA, Spiering MM, Ishmael FT, Trakselis MA, Benkovic SJ. Architecture of the bacteriophage T4 primosome: electron microscopy studies of helicase (gp41) and primase (gp61). Proceedings of the National Academy of Sciences of the United States of America. 102: 3623-6. PMID 15738414 DOI: 10.1073/Pnas.0500713102  0.647
2005 Zhang Z, Spiering MM, Trakselis MA, Ishmael FT, Xi J, Benkovic SJ, Hammes GG. Assembly of the bacteriophage T4 primosome: single-molecule and ensemble studies. Proceedings of the National Academy of Sciences of the United States of America. 102: 3254-9. PMID 15728347 DOI: 10.1073/Pnas.0500327102  0.665
2005 Xi J, Zhuang Z, Zhang Z, Selzer T, Spiering MM, Hammes GG, Benkovic SJ. Interaction between the T4 helicase-loading protein (gp59) and the DNA polymerase (gp43): a locking mechanism to delay replication during replisome assembly. Biochemistry. 44: 2305-18. PMID 15709743 DOI: 10.1021/Bi0479508  0.333
2005 Zhang Z, Spiering MM, Trakselis MA, Ishmael F, Xi J, Benkovic S, Hammes GG. Erratum: Assembly of the bacteriophage T4 primosome: Single-molecule and ensemble studies (Proceedings of the National Academy of Sciences of the United States of America (March 1, 2005) 102, 9 (3254-3259)) Proceedings of the National Academy of Sciences of the United States of America. 102: 13349-13350. DOI: 10.1073/Pnas.0506656102  0.613
2004 Venkitakrishnan RP, Zaborowski E, McElheny D, Benkovic SJ, Dyson HJ, Wright PE. Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle. Biochemistry. 43: 16046-55. PMID 15609999 DOI: 10.1021/Bi048119Y  0.362
2004 Joyce CM, Benkovic SJ. DNA polymerase fidelity: Kinetics, structure, and checkpoints Biochemistry. 43: 14317-14324. PMID 15533035 DOI: 10.1021/Bi048422Z  0.354
2004 Horswill AR, Savinov SN, Benkovic SJ. A systematic method for identifying small-molecule modulators of protein-protein interactions. Proceedings of the National Academy of Sciences of the United States of America. 101: 15591-6. PMID 15498867 DOI: 10.1073/Pnas.0406999101  0.552
2004 Millar D, Trakselis MA, Benkovic SJ. On the solution structure of the T4 sliding clamp (gp45). Biochemistry. 43: 12723-7. PMID 15461444 DOI: 10.1021/Bi048349C  0.635
2004 Horswill AR, Naumann TA, Benkovic SJ. Using incremental truncation to create libraries of hybrid enzymes. Methods in Enzymology. 388: 50-60. PMID 15289061 DOI: 10.1016/S0076-6879(04)88006-6  0.584
2004 Zhuang Z, Spiering MM, Berdis AJ, Trakselis MA, Benkovic SJ. 'Screw-cap' clamp loader proteins that thread. Nature Structural & Molecular Biology. 11: 580-1. PMID 15221017 DOI: 10.1038/Nsmb0704-580  0.646
2004 Yang J, Zhuang Z, Roccasecca RM, Trakselis MA, Benkovic SJ. The dynamic processivity of the T4 DNA polymerase during replication. Proceedings of the National Academy of Sciences of the United States of America. 101: 8289-94. PMID 15148377 DOI: 10.1073/Pnas.0402625101  0.671
2004 Saraf MC, Horswill AR, Benkovic SJ, Maranas CD. FamClash: a method for ranking the activity of engineered enzymes. Proceedings of the National Academy of Sciences of the United States of America. 101: 4142-7. PMID 14981242 DOI: 10.1073/Pnas.0400065101  0.557
2004 Zhang Z, Rajagopalan PT, Selzer T, Benkovic SJ, Hammes GG. Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate. Proceedings of the National Academy of Sciences of the United States of America. 101: 2764-9. PMID 14978269 DOI: 10.1073/Pnas.0400091101  0.352
2003 Lee SG, Lutz S, Benkovic SJ. On the structural and functional modularity of glycinamide ribonucleotide formyltransferases. Protein Science : a Publication of the Protein Society. 12: 2206-14. PMID 14500878 DOI: 10.1110/Ps.03139603  0.579
2003 Trakselis MA, Roccasecca RM, Yang J, Valentine AM, Benkovic SJ. Dissociative properties of the proteins within the bacteriophage T4 replisome. The Journal of Biological Chemistry. 278: 49839-49. PMID 14500719 DOI: 10.1074/Jbc.M307405200  0.783
2003 Yang J, Trakselis MA, Roccasecca RM, Benkovic SJ. The application of a minicircle substrate in the study of the coordinated T4 DNA replication. The Journal of Biological Chemistry. 278: 49828-38. PMID 14500718 DOI: 10.1074/Jbc.M307406200  0.692
2003 Desharnais J, Hwang I, Zhang Y, Tavassoli A, Baboval J, Benkovic SJ, Wilson IA, Boger DL. Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. Bioorganic & Medicinal Chemistry. 11: 4511-21. PMID 13129587 DOI: 10.1016/S0968-0896(03)00458-9  0.329
2003 Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA. Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site. Biochemistry. 42: 10904-14. PMID 12974624 DOI: 10.1021/Bi030106H  0.339
2003 Benkovic SJ, Hammes-Schiffer S. A perspective on enzyme catalysis. Science (New York, N.Y.). 301: 1196-202. PMID 12947189 DOI: 10.1126/Science.1085515  0.334
2003 Pineda P, Kanter A, McIvor RS, Benkovic SJ, Rosowsky A, Wagner CR. Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate. Journal of Medicinal Chemistry. 46: 2816-8. PMID 12825924 DOI: 10.1021/Jm034057I  0.525
2003 Huntley JJ, Fast W, Benkovic SJ, Wright PE, Dyson HJ. Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase. Protein Science : a Publication of the Protein Society. 12: 1368-75. PMID 12824483 DOI: 10.1110/Ps.0305303  0.637
2003 Zhang Y, Desharnais J, Marsilje TH, Li C, Hedrick MP, Gooljarsingh LT, Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Biochemistry. 42: 6043-56. PMID 12755606 DOI: 10.1021/Bi034219C  0.794
2003 Savinov SN, Hirschmann R, Benkovic SJ, Smith AB. Investigation of an antibody-ligase. Evidence for strain-induced catalysis. Bioorganic & Medicinal Chemistry Letters. 13: 1321-4. PMID 12657273 DOI: 10.1016/S0960-894X(03)00123-9  0.316
2003 Trakselis MA, Berdis AJ, Benkovic SJ. Examination of the role of the clamp-loader and ATP hydrolysis in the formation of the bacteriophage T4 polymerase holoenzyme. Journal of Molecular Biology. 326: 435-51. PMID 12559912 DOI: 10.1016/S0022-2836(02)01330-X  0.676
2003 Ishmael FT, Trakselis MA, Benkovic SJ. Protein-protein interactions in the bacteriophage T4 replisome. The leading strand holoenzyme is physically linked to the lagging strand holoenzyme and the primosome. The Journal of Biological Chemistry. 278: 3145-52. PMID 12427736 DOI: 10.1074/Jbc.M209858200  0.662
2002 Lutz S, Fast W, Benkovic SJ. A universal, vector-based system for nucleic acid reading-frame selection. Protein Engineering. 15: 1025-30. PMID 12601143 DOI: 10.1093/Protein/15.12.1025  0.699
2002 Rajagopalan PT, Lutz S, Benkovic SJ. Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates. Biochemistry. 41: 12618-28. PMID 12379104 DOI: 10.1021/Bi026369D  0.578
2002 Rajagopalan PT, Zhang Z, McCourt L, Dwyer M, Benkovic SJ, Hammes GG. Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. Proceedings of the National Academy of Sciences of the United States of America. 99: 13481-6. PMID 12359872 DOI: 10.1073/Pnas.172501499  0.349
2002 Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL. 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway. Bioorganic & Medicinal Chemistry. 10: 2739-49. PMID 12057663 DOI: 10.1016/S0968-0896(02)00102-5  0.782
2002 Thoden JB, Firestine SM, Benkovic SJ, Holden HM. PurT-encoded glycinamide ribonucleotide transformylase. Accommodation of adenosine nucleotide analogs within the active site. The Journal of Biological Chemistry. 277: 23898-908. PMID 11953435 DOI: 10.1074/Jbc.M202251200  0.334
2002 Rajagopalan PTR, Benkovic SJ. Preorganization and protein dynamics in enzyme catalysis Chemical Record. 2: 24-36. PMID 11933259 DOI: 10.1002/Tcr.10009  0.343
2001 Valentine AM, Ishmael FT, Shier VK, Benkovic SJ. A zinc ribbon protein in DNA replication: primer synthesis and macromolecular interactions by the bacteriophage T4 primase. Biochemistry. 40: 15074-85. PMID 11735390 DOI: 10.1021/Bi0108554  0.79
2001 Trakselis MA, Benkovic SJ. Intricacies in ATP-dependent clamp loading: variations across replication systems. Structure (London, England : 1993). 9: 999-1004. PMID 11709164 DOI: 10.1016/S0969-2126(01)00676-1  0.658
2001 Greasley SE, Marsilje TH, Cai H, Baker S, Benkovic SJ, Boger DL, Wilson IA. Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase Biochemistry. 40: 13538-13547. PMID 11695901 DOI: 10.1021/Bi011482+  0.388
2001 Lutz S, Ostermeier M, Moore GL, Maranas CD, Benkovic SJ. Creating multiple-crossover DNA libraries independent of sequence identity. Proceedings of the National Academy of Sciences of the United States of America. 98: 11248-53. PMID 11562494 DOI: 10.1073/Pnas.201413698  0.568
2001 Trakselis MA, Mayer MU, Ishmael FT, Roccasecca RM, Benkovic SJ. Dynamic protein interactions in the bacteriophage T4 replisome. Trends in Biochemical Sciences. 26: 566-72. PMID 11551794 DOI: 10.1016/S0968-0004(01)01929-6  0.668
2001 Alley SC, Trakselis MA, Mayer MU, Ishmael FT, Jones AD, Benkovic SJ. Building a replisome solution structure by elucidation of protein-protein interactions in the bacteriophage T4 DNA polymerase holoenzyme. The Journal of Biological Chemistry. 276: 39340-9. PMID 11504721 DOI: 10.1074/Jbc.M104956200  0.667
2001 Osborne MJ, Schnell J, Benkovic SJ, Dyson HJ, Wright PE. Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism. Biochemistry. 40: 9846-59. PMID 11502178 DOI: 10.1021/Bi010621K  0.33
2001 Trakselis MA, Alley SC, Abel-Santos E, Benkovic SJ. Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer. Proceedings of the National Academy of Sciences of the United States of America. 98: 8368-75. PMID 11459977 DOI: 10.1073/Pnas.111006698  0.65
2001 Shim JH, Wall M, Benkovic SJ, Diaz N, Suárez D, Merz JM. Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent kinetics, mutagenesis, and quantum chemical calculations Journal of the American Chemical Society. 123: 4687-4696. PMID 11457277 DOI: 10.1021/Ja010014K  0.349
2001 Wahnon DC, Shier VK, Benkovic SJ. Mechanism-based inhibition of an essential bacterial adenine DNA methyltransferase: rationally designed antibiotics. Journal of the American Chemical Society. 123: 976-7. PMID 11456633 DOI: 10.1021/Ja003285O  0.778
2001 Benkovic SJ, Valentine AM, Salinas F. Replisome-mediated DNA replication. Annual Review of Biochemistry. 70: 181-208. PMID 11395406 DOI: 10.1146/Annurev.Biochem.70.1.181  0.681
2001 Stevenson JD, Lutz S, Benkovic SJ. Retracing Enzyme Evolution in the (betaalpha)(8)-Barrel Scaffold. Angewandte Chemie (International Ed. in English). 40: 1854-1856. PMID 11385654 DOI: 10.1002/1521-3773(20010518)40:10<1854::Aid-Anie1854>3.0.Co;2-F  0.55
2001 Gooljarsingh LT, Ramcharan J, Gilroy S, Benkovic SJ. Localization of GAR transformylase in Escherichia coli and mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 6565-70. PMID 11381136 DOI: 10.1073/Pnas.121182998  0.784
2001 Fast W, Wang Z, Benkovic SJ. Familial mutations and zinc stoichiometry determine the rate-limiting step of nitrocefin hydrolysis by metallo-β-lactamase from Bacteroides fragilis Biochemistry. 40: 1640-1650. PMID 11327823 DOI: 10.1021/Bi001860V  0.657
2001 Greasley SE, Horton P, Ramcharan J, Beardsley GP, Benkovic SJ, Wilson IA. Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis. Nature Structural Biology. 8: 402-6. PMID 11323713 DOI: 10.1038/87555  0.72
2001 Ishmael FT, Norcum MT, Benkovic SJ, Bond JS. Multimeric Structure of the Secreted Meprin A Metalloproteinase and Characterization of the Functional Protomer Journal of Biological Chemistry. 276: 23207-23211. PMID 11301339 DOI: 10.1074/Jbc.M102654200  0.36
2001 Shier VK, Hancey CJ, Benkovic SJ. Identification of the active oligomeric state of an essential adenine DNA methyltransferase from Caulobacter crescentus. The Journal of Biological Chemistry. 276: 14744-51. PMID 11278726 DOI: 10.1074/Jbc.M010688200  0.791
2001 Moore GL, Maranas CD, Lutz S, Benkovic SJ. Predicting crossover generation in DNA shuffling. Proceedings of the National Academy of Sciences of the United States of America. 98: 3226-31. PMID 11248060 DOI: 10.1073/Pnas.051631498  0.514
2001 Miller GP, Wahnon DC, Benkovic SJ. Interloop contacts modulate ligand cycling during catalysis by Escherichia coli dihydrofolate reductase Biochemistry. 40: 867-875. PMID 11170407 DOI: 10.1021/Bi001608N  0.315
2001 Lutz S, Ostermeier M, Benkovic SJ. Rapid generation of incremental truncation libraries for protein engineering using alpha-phosphothioate nucleotides. Nucleic Acids Research. 29: E16. PMID 11160936 DOI: 10.1093/Nar/29.4.E16  0.577
2001 Ostermeier M, Benkovic SJ. Construction of hybrid gene libraries involving the circular permutation of DNA Biotechnology Letters. 23: 303-310. DOI: 10.1023/A:1005642725295  0.313
2001 Stevenson JD, Lutz S, Benkovic SJ. Auf der Spur der Evolution von einem als Gerüst in Enzymen dienenden (βα)8-Fass Angewandte Chemie. 113: 1906-1908. DOI: 10.1002/1521-3757(20010518)113:10<1906::Aid-Ange1906>3.0.Co;2-9  0.46
2000 Ostermeier M, Benkovic SJ. Evolution of protein function by domain swapping Advances in Protein Chemistry. 55: 29-78. PMID 11050932 DOI: 10.1016/S0065-3233(01)55002-0  0.303
2000 Wall M, Shim JH, Benkovic SJ. Human AICAR transformylase: Role of the 4-carboxamide of AICAR in binding and catalysis Biochemistry. 39: 11303-11311. PMID 10985775 DOI: 10.1021/Bi0007268  0.382
2000 Lutz S, Benkovic SJ. Homology-independent protein engineering. Current Opinion in Biotechnology. 11: 319-24. PMID 10975450 DOI: 10.1016/S0958-1669(00)00106-3  0.517
2000 Thoden JB, Firestine S, Nixon A, Benkovic SJ, Holden HM. Molecular structure of Escherichia coli purT-encoded glycinamide ribonucleotide transformylase Biochemistry. 39: 8791-8802. PMID 10913290 DOI: 10.1021/Bi000926J  0.388
2000 Boger DL, Marsilje TH, Castro RA, Hedrick MP, Jin Q, Baker SJ, Shim JH, Benkovic SJ. Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase Bioorganic and Medicinal Chemistry Letters. 10: 1471-1475. PMID 10888335 DOI: 10.1016/S0960-894X(00)00271-7  0.328
2000 Salinas F, Benkovic SJ. Characterization of bacteriophage T4-coordinated leading- and lagging-strand synthesis on a minicircle substrate. Proceedings of the National Academy of Sciences of the United States of America. 97: 7196-201. PMID 10860983 DOI: 10.1073/Pnas.97.13.7196  0.335
2000 Nixon AE, Benkovic SJ. Improvement in the efficiency of formyl transfer of a GAR transformylase hybrid enzyme Protein Engineering. 13: 323-327. PMID 10835105 DOI: 10.1093/Protein/13.5.323  0.348
2000 Bruice TC, Benkovic SJ. Chemical basis for enzyme catalysis. Biochemistry. 39: 6267-74. PMID 10828939 DOI: 10.1021/Bi0003689  0.487
2000 Firestine SM, Salinas F, Nixon AE, Baker SJ, Benkovic SJ. Using an AraC-based three-hybrid system to detect biocatalysts in vivo. Nature Biotechnology. 18: 544-7. PMID 10802623 DOI: 10.1038/75414  0.33
2000 Alley SC, Abel-Santos E, Benkovic SJ. Tracking sliding clamp opening and closing during bacteriophage T4 DNA polymerase holoenzyme assembly. Biochemistry. 39: 3076-90. PMID 10715129 DOI: 10.1021/Bi992377R  0.335
2000 Benkovic SJ, Gooljarsingh L, Ramcharan J, Shim JH, Wall M. The Transformylase Enzymes in de Novo Purine Biosynthesis Biochemical Society Transactions. 28: A122-A122. DOI: 10.1042/bst028a122c  0.781
2000 Alley SC, Ishmael FT, Jones AD, Benkovic SJ. Mapping protein - Protein interactions in the bacteriophage T4 DNA polymerase holoenzyme using a novel trifunctional photo-cross-linking and affinity reagent [11] Journal of the American Chemical Society. 122: 6126-6127. DOI: 10.1021/Ja000591T  0.306
2000 Baker SJ, Firestine SM, Smithrud D, Salinas F, Benkovic SJ. Synthesis of two bi-functional ligands for the QUEST three-hybrid system Tetrahedron Letters. 41: 7009-7012. DOI: 10.1016/S0040-4039(00)01202-8  0.304
1999 Greasley SE, Yamashita MM, Cai H, Benkovic SJ, Boger DL, Wilson IA. New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid. Biochemistry. 38: 16783-93. PMID 10606510 DOI: 10.1021/Bi991888A  0.368
1999 Ostermeier M, Shim JH, Benkovic SJ. A combinatorial approach to hybrid enzymes independent of DNA homology Nature Biotechnology. 17: 1205-1209. PMID 10585719 DOI: 10.1038/70754  0.339
1999 Ostermeier M, Nixon AE, Benkovic SJ. Incremental truncation as a strategy in the engineering of novel biocatalysts Bioorganic and Medicinal Chemistry. 7: 2139-2144. PMID 10579518 DOI: 10.1016/S0968-0896(99)00143-1  0.349
1999 Scott CP, Abel-Santos E, Wall M, Wahnon DC, Benkovic SJ. Production of cyclic peptides and proteins in vivo Proceedings of the National Academy of Sciences of the United States of America. 96: 13638-13643. PMID 10570125 DOI: 10.1073/Pnas.96.24.13638  0.303
1999 Scrofani SD, Chung J, Huntley JJ, Benkovic SJ, Wright PE, Dyson HJ. NMR characterization of the metallo-beta-lactamase from Bacteroides fragilis and its interaction with a tight-binding inhibitor: role of an active-site loop. Biochemistry. 38: 14507-14. PMID 10545172 DOI: 10.1021/Bi990986T  0.335
1999 Wang Z, Fast W, Valentine AM, Benkovic SJ. Metallo-beta-lactamase: structure and mechanism. Current Opinion in Chemical Biology. 3: 614-22. PMID 10508665 DOI: 10.1016/S1367-5931(99)00017-4  0.747
1999 Alley SC, Jones AD, Soumillion P, Benkovic SJ. The carboxyl terminus of the bacteriophage T4 DNA polymerase contacts its sliding clamp at the subunit interface. The Journal of Biological Chemistry. 274: 24485-9. PMID 10455110 DOI: 10.1074/Jbc.274.35.24485  0.337
1999 Thayer MM, Olender EH, Arvai AS, Koike CK, Canestrelli IL, Stewart JD, Benkovic SJ, Getzoff ED, Roberts VA. Structural basis for amide hydrolysis catalyzed by the 43C9 antibody. Journal of Molecular Biology. 291: 329-45. PMID 10438624 DOI: 10.1006/Jmbi.1999.2960  0.321
1999 Shim JH, Benkovic SJ. Catalytic mechanism of Escherichia coli glycinamide ribonucleotide transformylase probed by site-directed mutagenesis and pH-dependent studies Biochemistry. 38: 10024-10031. PMID 10433709 DOI: 10.1021/Bi9904609  0.35
1999 Wang Z, Fast W, Benkovic SJ. On the mechanism of the metallo-beta-lactamase from Bacteroides fragilis. Biochemistry. 38: 10013-23. PMID 10433708 DOI: 10.1021/Bi990356R  0.649
1999 Alley SC, Shier VK, Abel-Santos E, Sexton DJ, Soumillion P, Benkovic SJ. Sliding clamp of the bacteriophage T4 polymerase has open and closed subunit interfaces in solution. Biochemistry. 38: 7696-709. PMID 10387009 DOI: 10.1021/Bi9827971  0.784
1999 Nixon AE, Firestine SM, Salinas FG, Benkovic SJ. Rational design of a scytalone dehydratase-like enzyme using a structurally homologous protein scaffold. Proceedings of the National Academy of Sciences of the United States of America. 96: 3568-71. PMID 10097077 DOI: 10.1073/Pnas.96.7.3568  0.378
1999 Ostermeier M, Nixon AE, Shim JH, Benkovic SJ. Combinatorial protein engineering by incremental truncation. Proceedings of the National Academy of Sciences of the United States of America. 96: 3562-7. PMID 10097076 DOI: 10.1073/Pnas.96.7.3562  0.381
1998 Wu P, Nossal N, Benkovic SJ. Kinetic characterization of a bacteriophage T4 antimutator DNA polymerase. Biochemistry. 37: 14748-55. PMID 9778349 DOI: 10.1021/Bi980835A  0.373
1998 Cannon WR, Benkovic SJ. Solvation, reorganization energy, and biological catalysis. The Journal of Biological Chemistry. 273: 26257-60. PMID 9756847 DOI: 10.1074/Jbc.273.41.26257  0.61
1998 Berdis AJ, Benkovic SJ. Simultaneous formation of functional leading and lagging strand holoenzyme complexes on a small, defined DNA substrate. Proceedings of the National Academy of Sciences of the United States of America. 95: 11128-33. PMID 9736701 DOI: 10.1073/Pnas.95.19.11128  0.36
1998 Wang Z, Benkovic SJ. Purification, characterization, and kinetic studies of a soluble Bacteroides fragilis metallo-beta-lactamase that provides multiple antibiotic resistance. The Journal of Biological Chemistry. 273: 22402-8. PMID 9712862 DOI: 10.1074/Jbc.273.35.22402  0.315
1998 Boger DL, Kochanny MJ, Cai H, Wyatt D, Kitos PA, Warren MS, Ramcharan J, Gooljarsingh LT, Benkovic SJ. Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors. Bioorganic & Medicinal Chemistry. 6: 643-59. PMID 9681131 DOI: 10.1016/S0968-0896(98)00040-6  0.764
1998 Sexton DJ, Berdis AJ, Benkovic SJ. Assembly and disassembly of DNA polymerase holoenzyme. Current Opinion in Chemical Biology. 1: 316-22. PMID 9667868 DOI: 10.1016/S1367-5931(97)80068-3  0.342
1998 Nixon AE, Ostermeier M, Benkovic SJ. Hybrid enzymes: Manipulating enzyme design Trends in Biotechnology. 16: 258-264. PMID 9652137 DOI: 10.1016/S0167-7799(98)01204-9  0.332
1998 Shim JH, Benkovic SJ. Evaluation of the kinetic mechanism of Escherichia coli glycinamide ribonucleotide transformylase Biochemistry. 37: 8776-8782. PMID 9628739 DOI: 10.1021/Bi980244K  0.313
1998 Sexton DJ, Kaboord BF, Berdis AJ, Carver TE, Benkovic SJ. Dissecting the order of bacteriophage T4 DNA polymerase holoenzyme assembly. Biochemistry. 37: 7749-56. PMID 9601035 DOI: 10.1021/Bi980088H  0.368
1998 Miller GP, Benkovic SJ. Stretching exercises - Flexibility in dihydrofolate reductase catalysis Chemistry and Biology. 5. PMID 9578637 DOI: 10.1016/S1074-5521(98)90616-0  0.308
1998 Miller GP, Benkovic SJ. Strength of an interloop hydrogen bond determines the kinetic pathway in catalysis by Escherichia coli dihydrofolate reductase Biochemistry. 37: 6336-6342. PMID 9572848 DOI: 10.1021/Bi973065W  0.327
1998 Miller GP, Benkovic SJ. Depletion of a highly motional residue affects formation of the Michaelis complex for Escherichia coli dihydrofolate reductase Biochemistry. 37: 6327-6335. PMID 9572847 DOI: 10.1021/Bi972922T  0.355
1998 Kroutil LC, Frey MW, Kaboord BF, Kunkel TA, Benkovic SJ. Effect of accessory proteins on T4 DNA polymerase replication fidelity. Journal of Molecular Biology. 278: 135-46. PMID 9571039 DOI: 10.1006/Jmbi.1998.1676  0.351
1998 Berdis AJ, Lee I, Coward JK, Stephens C, Wright R, Shapiro L, Benkovic SJ. A cell cycle-regulated adenine DNA methyltransferase from Caulobacter crescentus processively methylates GANTC sites on hemimethylated DNA. Proceedings of the National Academy of Sciences of the United States of America. 95: 2874-9. PMID 9501183 DOI: 10.1073/Pnas.95.6.2874  0.611
1998 Soumillion P, Sexton DJ, Benkovic SJ. Clamp subunit dissociation dictates bacteriophage T4 DNA polymerase holoenzyme disassembly. Biochemistry. 37: 1819-27. PMID 9485307 DOI: 10.1021/Bi972526A  0.356
1998 Zhong W, Benkovic SJ. Development of an internally quenched fluorescent substrate for Escherichia coli leader peptidase Analytical Biochemistry. 255: 66-73. PMID 9448843 DOI: 10.1006/Abio.1997.2471  0.315
1998 Wang Z, Fast W, Benkovic SJ. Direct Observation of an Enzyme-Bound Intermediate in the Catalytic Cycle of the Metallo-β-Lactamase fromBacteroides fragilis Journal of the American Chemical Society. 120: 10788-10789. DOI: 10.1021/Ja982621M  0.632
1997 Cameron CE, Benkovic SJ. Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant Biochemistry. 36: 15792-15800. PMID 9398309 DOI: 10.1021/Bi9716231  0.562
1997 Carver TE, Sexton DJ, Benkovic SJ. Dissociation of bacteriophage T4 DNA polymerase and its processivity clamp after completion of Okazaki fragment synthesis. Biochemistry. 36: 14409-17. PMID 9398159 DOI: 10.1021/Bi971423P  0.352
1997 Boger DL, Haynes NE, Warren MS, Ramcharan J, Kitos PA, Benkovic SJ. Multisubstrate analogue based on 5,8,10-trideazafolate. Bioorganic & Medicinal Chemistry. 5: 1853-7. PMID 9354241 DOI: 10.1016/S0968-0896(97)00124-7  0.7
1997 Boger DL, Haynes NE, Warren MS, Ramcharan J, Marolewski AE, Kitos PA, Benkovic SJ. Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase. Bioorganic & Medicinal Chemistry. 5: 1847-52. PMID 9354240 DOI: 10.1016/S0968-0896(97)00123-5  0.726
1997 Boger DL, Haynes NE, Warren MS, Ramcharan J, Kitos PA, Benkovic SJ. Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase. Bioorganic & Medicinal Chemistry. 5: 1839-46. PMID 9354239 DOI: 10.1016/S0968-0896(97)00122-3  0.742
1997 Boger DL, Haynes NE, Warren MS, Gooljarsingh LT, Ramcharan J, Kitos PA, Benkovic SJ. Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase. Bioorganic & Medicinal Chemistry. 5: 1831-8. PMID 9354238 DOI: 10.1016/S0968-0896(97)00121-1  0.771
1997 Boger DL, Haynes NE, Kitos PA, Warren MS, Ramcharan J, Marolewski AE, Benkovic SJ. 10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase. Bioorganic & Medicinal Chemistry. 5: 1817-30. PMID 9354237 DOI: 10.1016/S0968-0896(97)00120-X  0.71
1997 Cannon WR, Garrison BJ, Benkovic SJ. Consideration of the pH-dependent inhibition of dihydrofolate reductase by methotrexate. Journal of Molecular Biology. 271: 656-68. PMID 9281432 DOI: 10.1006/Jmbi.1997.1173  0.678
1997 Smithrud DB, Benkovic SJ. The state of antibody catalysis Current Opinion in Biotechnology. 8: 459-466. PMID 9265726 DOI: 10.1016/S0958-1669(97)80069-9  0.316
1997 Cameron CE, Ghosh M, Le Grice SFJ, Benkovic SJ. Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein Proceedings of the National Academy of Sciences of the United States of America. 94: 6700-6705. PMID 9192628 DOI: 10.1073/Pnas.94.13.6700  0.555
1997 Marolewski AE, Mattia KM, Warren MS, Benkovic SJ. Formyl phosphate: a proposed intermediate in the reaction catalyzed by Escherichia coli PurT GAR transformylase. Biochemistry. 36: 6709-16. PMID 9184151 DOI: 10.1021/Bi962961P  0.379
1997 Berdis AJ, Benkovic SJ. Mechanism of bacteriophage T4 DNA holoenzyme assembly: the 44/62 protein acts as a molecular motor. Biochemistry. 36: 2733-43. PMID 9062100 DOI: 10.1021/Bi962139L  0.371
1997 Warren MS, Benkovic SJ. Combinatorial manipulation of three key active site residues in glycinamide ribonucleotide transformylase. Protein Engineering. 10: 63-8. PMID 9051735 DOI: 10.1093/Protein/10.1.63  0.35
1997 Nixon AE, Warren MS, Benkovic SJ. Assembly of an active enzyme by the linkage of two protein modules. Proceedings of the National Academy of Sciences of the United States of America. 94: 1069-73. PMID 9037007 DOI: 10.1073/Pnas.94.4.1069  0.365
1997 Smithrud DB, Benkovic PA, Benkovic SJ, Taylor CM, Yager KM, Witherington J, Philips BW, Sprengeler PA, Smith AB, Hirschmann R. Investigations of an antibody ligase Journal of the American Chemical Society. 119: 278-282. DOI: 10.1021/Ja963167U  0.332
1997 Cannon WR, Garrison BJ, Benkovic SJ. Electrostatic Characterization of Enzyme Complexes:  Evaluation of the Mechanism of Catalysis of Dihydrofolate Reductase Journal of the American Chemical Society. 119: 2386-2395. DOI: 10.1021/Ja962621R  0.677
1996 Firestine SM, Nixon AE, Benkovic SJ. Threading your way to protein function. Chemistry & Biology. 3: 779-83. PMID 8939694 DOI: 10.1016/S1074-5521(96)90061-7  0.311
1996 Berdis AJ, Soumillion P, Benkovic SJ. The carboxyl terminus of the bacteriophage T4 DNA polymerase is required for holoenzyme complex formation. Proceedings of the National Academy of Sciences of the United States of America. 93: 12822-7. PMID 8917503 DOI: 10.1073/Pnas.93.23.12822  0.362
1996 Sexton DJ, Carver TE, Berdis AJ, Benkovic SJ. Protein-protein and protein-DNA interactions at the bacteriophage T4 DNA replication fork. Characterization of a fluorescently labeled DNA polymerase sliding clamp. The Journal of Biological Chemistry. 271: 28045-51. PMID 8910415 DOI: 10.1074/Jbc.271.45.28045  0.363
1996 Cannon WR, Singleton SF, Benkovic SJ. A perspective on biological catalysis. Nature Structural Biology. 3: 821-33. PMID 8836096 DOI: 10.1038/Nsb1096-821  0.676
1996 Crowder MW, Wang Z, Franklin SL, Zovinka EP, Benkovic SJ. Characterization of the metal-binding sites of the beta-lactamase from Bacteroides fragilis. Biochemistry. 35: 12126-32. PMID 8810919 DOI: 10.1021/Bi960976H  0.682
1996 Frey MW, Frey ST, Horrocks WDW, Kaboord BF, Benkovic SJ. Elucidation of the metal-binding properties of the Klenow fragment of Escherichia coli polymerase I and bacteriophage T4 DNA polymerase by lanthanide(III) luminescence spectroscopy Chemistry and Biology. 3: 393-403. PMID 8807868 DOI: 10.1016/S1074-5521(96)90122-2  0.34
1996 Berdis AJ, Benkovic SJ. Role of adenosine 5'-triphosphate hydrolysis in the assembly of the bacteriophage T4 DNA replication holoenzyme complex. Biochemistry. 35: 9253-65. PMID 8703931 DOI: 10.1021/Bi952569W  0.373
1996 Warren MS, Marolewski AE, Benkovic SJ. A rapid screen of active site mutants in glycinamide ribonucleotide transformylase. Biochemistry. 35: 8855-62. PMID 8688421 DOI: 10.1021/Bi9528715  0.335
1996 Raney KD, Carver TE, Benkovic SJ. Stoichiometry and DNA unwinding by the bacteriophage T4 41:59 helicase. The Journal of Biological Chemistry. 271: 14074-81. PMID 8662873 DOI: 10.1074/Jbc.271.24.14074  0.372
1996 Posner BA, Li L, Bethell R, Tsuji T, Benkovic SJ. Engineering specificity for folate into dihydrofolate reductase from Escherichia coli. Biochemistry. 35: 1653-63. PMID 8634297 DOI: 10.1021/Bi9518095  0.379
1996 Kaboord BF, Benkovic SJ. Dual role of the 44/62 protein as a matchmaker protein and DNA polymerase chaperone during assembly of the bacteriophage T4 holoenzyme complex. Biochemistry. 35: 1084-92. PMID 8547244 DOI: 10.1021/Bi9520747  0.328
1996 Warren MS, Mattia KM, Marolewski AE, Benkovic SJ. The transformylase enzymes of de novo purine biosynthesis Pure and Applied Chemistry. 68: 2029-2036. DOI: 10.1351/Pac199668112029  0.325
1996 Anderson GT, Alexander MD, Taylor SD, Smithrud DB, Benkovic SJ, Weinreb SM. Catalytic antibodies in synthesis: Design and synthesis of a hapten for application to the preparation of a scalemic pyrrolidine ring synthon for ptilomycalin A Journal of Organic Chemistry. 61: 125-132. DOI: 10.1021/Jo951469T  0.316
1995 Capson TL, Benkovic SJ, Nossal NG. Photochemical cross-linking of DNA replication proteins at primer terminus. Methods in Enzymology. 262: 449-56. PMID 8594369 DOI: 10.1016/0076-6879(95)62036-2  0.356
1995 Benkovic SJ, Cameron CE. Kinetic analysis of nucleotide incorporation and misincorporation by Klenow fragment of Escherichia coli DNA polymerase I Methods in Enzymology. 262: 257-269. PMID 8594352 DOI: 10.1016/0076-6879(95)62022-2  0.565
1995 Le Grice SFJ, Cameron CE, Benkovic SJ. Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase Methods in Enzymology. 262: 130-144. PMID 8594344 DOI: 10.1016/0076-6879(95)62015-X  0.506
1995 Lee I, Stewart JD, Zhong WY, Benkovic SJ. A Chemiluminescent Immunoassay for the Identification of Functional Single-Chain Antibodies Analytical Biochemistry. 230: 62-67. PMID 8585631 DOI: 10.1006/Abio.1995.1438  0.3
1995 Nagy PL, Marolewski A, Benkovic SJ, Zalkin H. Formyltetrahydrofolate hydrolase, a regulatory enzyme that functions to balance pools of tetrahydrofolate and one-carbon tetrahydrofolate adducts in Escherichia coli. Journal of Bacteriology. 177: 1292-8. PMID 7868604 DOI: 10.1128/Jb.177.5.1292-1298.1995  0.374
1995 Stewart JD, Lee I, Posner BA, Benkovic SJ. Expression of properly folded catalytic antibodies in Escherichia coli Methods in Enzymology. 249: 507-519. PMID 7791625 DOI: 10.1016/0076-6879(95)49047-7  0.313
1995 Carr RT, Balasubramanian S, Hawkins PC, Benkovic SJ. Mechanism of metal-independent hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase. Biochemistry. 34: 7525-32. PMID 7779797 DOI: 10.1021/Bi00022A028  0.483
1995 Klein C, Chen P, Arevalo JH, Stura EA, Marolewski A, Warren MS, Benkovic SJ, Wilson IA. Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution. Journal of Molecular Biology. 249: 153-75. PMID 7776369 DOI: 10.1006/Jmbi.1995.0286  0.355
1995 Stewart JD, Benkovic SJ. Transition-state stabilization as a measure of the efficiency of antibody catalysis Nature. 375: 388-391. PMID 7760931 DOI: 10.1038/375388A0  0.308
1995 Kaboord BF, Benkovic SJ. Accessory proteins function as matchmakers in the assembly of the T4 DNA polymerase holoenzyme. Current Biology : Cb. 5: 149-57. PMID 7743178 DOI: 10.1016/S0960-9822(95)00036-4  0.338
1995 Raney KD, Benkovic SJ. Bacteriophage T4 Dda helicase translocates in a unidirectional fashion on single-stranded DNA Journal of Biological Chemistry. 270: 22236-22242. PMID 7673202 DOI: 10.1074/Jbc.270.38.22236  0.334
1995 Epstein DM, Benkovic SJ, Wright PE. Dynamics of the dihydrofolate reductase-folate complex: Catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features Biochemistry. 34: 11037-11048. PMID 7669761 DOI: 10.1021/Bi00035A009  0.302
1995 Frey MW, Sowers LC, Millar DP, Benkovic SJ. The nucleotide analog 2-aminopurine as a spectroscopic probe of nucleotide incorporation by the Klenow fragment of Escherichia coli polymerase I and bacteriophage T4 DNA polymerase Biochemistry. 34: 9185-9192. PMID 7619819 DOI: 10.1021/Bi00028A031  0.361
1995 Cirino NM, Cameron CE, Smith JS, Rausch JW, Roth MJ, Benkovic SJ, Le Grice SFJ. Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase Biochemistry. 34: 9936-9943. PMID 7543283 DOI: 10.1021/Bi00031A016  0.56
1995 Ghosh M, Howard KJ, Cameron CE, Benkovic SJ, Hughes SH, Le Grice SFJ. Truncating α-Helix E′ of p66 human immunodeficiency virus reverse transcriptase modulates RNase H function and impairs DNA strand transfer Journal of Biological Chemistry. 270: 7068-7076. PMID 7535765 DOI: 10.1074/Jbc.270.13.7068  0.519
1995 Wagner CR, Huang Z, Singleton SF, Benkovic SJ. Molecular basis for nonadditive mutational effects in Escherichia coli dihydrofolate reductase. Biochemistry. 34: 15671-80. PMID 7495797 DOI: 10.1021/Bi00048A011  0.575
1995 Crowder MW, Stewart JD, Roberts VA, Bender CJ, Tevelrakh E, Peisach J, Getzoff ED, Gaffney BJ, Benkovic SJ. Spectroscopic Studies on the Designed Metal-Binding Sites of the 43C9 Single Chain Antibody Journal of the American Chemical Society. 117: 5627-5634. DOI: 10.1021/Ja00126A003  0.541
1995 Liotta LJ, Gibbs RA, Taylor SD, Benkovic PA, Benkovic SJ. Antibody-Catalyzed Rearrangement of a Peptide Bond: Mechanistic and Kinetic Investigations Journal of the American Chemical Society. 117: 4729-4741. DOI: 10.1021/Ja00122A001  0.737
1994 Falzone CJ, Wright PE, Benkovic SJ. Dynamics of a flexible loop in dihydrofolate reductase from Escherichia coli and its implication for catalysis Biochemistry. 33: 439-442. PMID 8286374 DOI: 10.1021/Bi00168A007  0.301
1994 Marolewski A, Smith JM, Benkovic SJ. Cloning and characterization of a new purine biosynthetic enzyme: a non-folate glycinamide ribonucleotide transformylase from E. coli. Biochemistry. 33: 2531-7. PMID 8117714 DOI: 10.1021/Bi00175A023  0.337
1994 Stewart JD, Roberts VA, Thomas NR, Getzoff ED, Benkovic SJ. Site-directed mutagenesis of a catalytic antibody: an arginine and a histidine residue play key roles. Biochemistry. 33: 1994-2003. PMID 8117656 DOI: 10.1021/Bi00174A004  0.316
1994 Smiley JA, Benkovic SJ. Selection of catalytic antibodies for a biosynthetic reaction from a combinatorial cDNA library by complementation of an auxotrophic Escherichia coli: antibodies for orotate decarboxylation. Proceedings of the National Academy of Sciences of the United States of America. 91: 8319-23. PMID 8078880 DOI: 10.1073/Pnas.91.18.8319  0.314
1994 Stewart JD, Krebs JF, Siuzdak G, Berdis AJ, Smithrud DB, Benkovic SJ. Dissection of an antibody-catalyzed reaction Proceedings of the National Academy of Sciences of the United States of America. 91: 7404-7409. PMID 8052597 DOI: 10.1073/Pnas.91.16.7404  0.355
1994 Balasubramanian S, Carr RT, Bender CJ, Peisach J, Benkovic SJ. Identification of metal ligands in Cu(II)-inhibited Chromobacterium violaceum phenylalanine hydroxylase by electron spin echo envelope modulation analysis of histidine to serine mutations. Biochemistry. 33: 8532-7. PMID 8031788 DOI: 10.1021/Bi00194A019  0.511
1994 Hirschmann R, Smith AB, Taylor CM, Benkovic PA, Taylor SD, Yager KM, Sprengeler PA, Benkovic SJ. Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids. Science (New York, N.Y.). 265: 234-7. PMID 8023141 DOI: 10.1126/Science.8023141  0.323
1994 Raney KD, Sowers LC, Millar DP, Benkovic SJ. A fluorescence-based assay for monitoring helicase activity Proceedings of the National Academy of Sciences of the United States of America. 91: 6644-6648. PMID 8022830 DOI: 10.1073/Pnas.91.14.6644  0.316
1994 Huang Z, Wagner CR, Benkovic SJ. Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase. Biochemistry. 33: 11576-85. PMID 7918371 DOI: 10.1021/Bi00204A020  0.58
1994 Peliska JA, Balasubramanian S, Giedroc DP, Benkovic SJ. Recombinant HIV-1 nucleocapsid protein accelerates HIV-1 reverse transcriptase catalyzed DNA strand transfer reactions and modulates RNase H activity. Biochemistry. 33: 13817-23. PMID 7524664 DOI: 10.1021/Bi00250A036  0.482
1994 Peliska JA, Benkovic SJ. Fidelity of in vitro DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase. Biochemistry. 33: 3890-5. PMID 7511410 DOI: 10.1021/Bi00179A014  0.34
1994 Siuzdak G, Krebs JF, Benkovic SJ, Dyson HJ. Binding of hapten to a single-chain catalytic antibody demonstrated by electrospray mass spectrometry Journal of the American Chemical Society. 116: 7937-7938. DOI: 10.1021/Ja00096A077  0.324
1994 Ganem B, Li YT, Hsieh YL, Henion JD, Kaboord BF, Frey MW, Benkovic SJ. Analysis of the Stoichiometry of the T4 Gene 45 Protein by Ion Spray Mass Spectrometry Journal of the American Chemical Society. 116: 1352-1358. DOI: 10.1021/Ja00083A021  0.548
1994 Stewart JD, Roberts VA, Crowder MW, Getzoff ED, Benkovic SJ. Creation of a novel biosensor for zinc(II) Journal of the American Chemical Society. 116: 415-416. DOI: 10.1021/Ja00080A065  0.507
1993 Posner B, Lee I, Itoh T, Pyati J, Graff R, Thorton GB, La Polla R, Benkovic SJ. A revised strategy for cloning antibody gene fragments in bacteria. Gene. 128: 111-7. PMID 8508951 DOI: 10.1016/0378-1119(93)90161-U  0.304
1993 Frey MW, Nossal NG, Capson TL, Benkovic SJ. Construction and characterization of a bacteriophage T4 DNA polymerase deficient in 3'-->5' exonuclease activity. Proceedings of the National Academy of Sciences of the United States of America. 90: 2579-83. PMID 8464864 DOI: 10.1073/Pnas.90.7.2579  0.334
1993 Balasubramanian S, Carr RT, Bender CJ, Peisach J, Benkovic SJ. Histidines 138 and 143 are copper binding ligands in Chromobacterium violaceum phenylalanine hydroxylase. Advances in Experimental Medicine and Biology. 338: 67-70. PMID 8304204 DOI: 10.1007/978-1-4615-2960-6_13  0.461
1993 Kaboord BF, Benkovic SJ. Rapid assembly of the bacteriophage T4 core replication complex on a linear primer/template construct. Proceedings of the National Academy of Sciences of the United States of America. 90: 10881-5. PMID 8248185 DOI: 10.1073/Pnas.90.22.10881  0.365
1993 Roberts VA, Stewart J, Benkovic SJ, Getzoff ED. Catalytic Antibody Model And Site-Directed Mutagenesis Implicate Arginine And Histidine In Catalytic Mechanism Protein Engineering Design & Selection. 6: 85-85. DOI: 10.1093/Protein/6.Supplement.85-B  0.301
1993 Liotta LJ, Benkovic PA, Miller GP, Benkovic SJ. Catalytic antibody for imide hydrolysis featuring a bifunctional transition-state mimic Journal of the American Chemical Society. 115: 350-351. DOI: 10.1021/Ja00054A053  0.712
1993 Stewart JD, Liotta LJ, Benkovic SJ. Reaction mechanisms displayed by catalytic antibodies Accounts of Chemical Research. 26: 396-404. DOI: 10.1021/Ar00032A002  0.72
1993 Crowder M, Stewart J, Roberts V, Getzoff E, Benkovic S. Design, preparation and characterization of a de novo metal binding site in single chain catalytic antibody 43C9. Journal of Inorganic Biochemistry. 51: 76. DOI: 10.1016/0162-0134(93)85112-L  0.494
1992 Benkovic SJ, Adams J, Janda KD, Lerner RA. A catalytic antibody uses a multistep kinetic sequence. Ciba Foundation Symposium. 159: 4-9; discussion 9-12. PMID 1959451 DOI: 10.1002/9780470514108.ch2  0.419
1992 Chen P, Schulze-Gahmen U, Stura EA, Inglese J, Johnson DL, Marolewski A, Benkovic SJ, Wilson IA. Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy. Journal of Molecular Biology. 227: 283-92. PMID 1522592 DOI: 10.1016/0022-2836(92)90698-J  0.378
1992 Wagner CR, Thillet J, Benkovic SJ. Complementary perturbation of the kinetic mechanism and catalytic effectiveness of dihydrofolate reductase by side-chain interchange. Biochemistry. 31: 7834-40. PMID 1510969 DOI: 10.1021/Bi00149A013  0.547
1992 Wagner CR, Benkovic SJ. Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis. Journal of Medicinal Chemistry. 35: 2912-5. PMID 1495020 DOI: 10.1021/Jm00093A026  0.506
1992 Gibbs RA, Taylor S, Benkovic SJ. Antibody-catalyzed rearrangement of the peptide bond. Science (New York, N.Y.). 258: 803-5. PMID 1439788 DOI: 10.1126/Science.1439788  0.465
1992 Capson TL, Peliska JA, Kaboord BF, Frey MW, Lively C, Dahlberg M, Benkovic SJ. Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4. Biochemistry. 31: 10984-94. PMID 1332748 DOI: 10.1021/Bi00160A007  0.38
1992 Eger BT, Benkovic SJ. Minimal kinetic mechanism for misincorporation by DNA polymerase I (Klenow fragment). Biochemistry. 31: 9227-36. PMID 1327109 DOI: 10.1021/Bi00153A016  0.355
1992 Peliska JA, Benkovic SJ. Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase. Science (New York, N.Y.). 258: 1112-8. PMID 1279806 DOI: 10.1126/Science.1279806  0.307
1992 Gopalakrishnan V, Peliska JA, Benkovic SJ. Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities. Proceedings of the National Academy of Sciences of the United States of America. 89: 10763-7. PMID 1279694 DOI: 10.1073/Pnas.89.22.10763  0.31
1992 Gibbs RA, Benkovic PA, Janda KD, Lerner RA, Benkovic SJ. Substituent effects of an antibody-catalyzed hydrolysis of phenyl esters: further evidence for an acyl-antibody intermediate Journal of the American Chemical Society. 114: 3528-3534. DOI: 10.1021/Ja00035A057  0.573
1991 Wirsching P, Ashley JA, Benkovic SJ, Janda KD, Lerner RA. An unexpectedly efficient catalytic antibody operating by ping-pong and induced fit mechanisms. Science (New York, N.Y.). 252: 680-5. PMID 2024120 DOI: 10.1126/Science.2024120  0.506
1991 Lerner RA, Benkovic SJ, Schultz PG. At the crossroads of chemistry and immunology: catalytic antibodies. Science (New York, N.Y.). 252: 659-67. PMID 2024118 DOI: 10.1126/Science.2024118  0.477
1991 Gibbs RA, Posner BA, Filpula DR, Dodd SW, Finkelman MA, Lee TK, Wroble M, Whitlow M, Benkovic SJ. Construction and characterization of a single-chain catalytic antibody. Proceedings of the National Academy of Sciences of the United States of America. 88: 4001-4. PMID 2023948 DOI: 10.1073/Pnas.88.9.4001  0.449
1991 Falzone CJ, Wright PE, Benkovic SJ. Evidence for two interconverting protein isomers in the methotrexate complex of dihydrofolate reductase from Escherichia coli Biochemistry. 30: 2184-2191. PMID 1998678 DOI: 10.1021/Bi00222A023  0.324
1991 Li LY, Benkovic SJ. Impact on catalysis of secondary structural manipulation of the alpha C-helix of Escherichia coli dihydrofolate reductase. Biochemistry. 30: 1470-8. PMID 1993166 DOI: 10.1021/Bi00220A004  0.343
1991 Eger BT, Kuchta RD, Carroll SS, Benkovic PA, Dahlberg ME, Joyce CM, Benkovic SJ. Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-) Biochemistry. 30: 1441-1448. PMID 1991125 DOI: 10.1021/Bi00219A039  0.356
1991 Cowart M, Benkovic SJ. A novel combined chemical-enzymatic synthesis of cross-linked DNA using a nucleoside triphosphate analogue. Biochemistry. 30: 788-96. PMID 1988067 DOI: 10.1021/Bi00217A032  0.343
1991 Kang AS, Barbas CF, Janda KD, Benkovic SJ, Lerner RA. Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces. Proceedings of the National Academy of Sciences of the United States of America. 88: 4363-6. PMID 1903540 DOI: 10.1073/Pnas.88.10.4363  0.464
1991 Carroll SS, Cowart M, Benkovic SJ. A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity. Biochemistry. 30: 804-13. PMID 1899034 DOI: 10.1021/Bi00217A034  0.372
1991 Barbas CF, Kang AS, Lerner RA, Benkovic SJ. Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proceedings of the National Academy of Sciences of the United States of America. 88: 7978-82. PMID 1896445 DOI: 10.1073/Pnas.88.18.7978  0.458
1991 Capson TL, Benkovic SJ, Nossal NG. Protein-DNA cross-linking demonstrates stepwise ATP-dependent assembly of T4 DNA polymerase and its accessory proteins on the primer-template. Cell. 65: 249-58. PMID 1849797 DOI: 10.1016/0092-8674(91)90159-V  0.362
1991 Sastry L, Mubaraki M, Janda KD, Benkovic SJ, Lerner RA. Screening combinatorial antibody libraries for catalytic acyl transfer reactions. Ciba Foundation Symposium. 159: 145-51; discussion 1. PMID 1835693 DOI: 10.1002/9780470514108.ch10  0.399
1991 Adams JA, Fierke CA, Benkovic SJ. The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli. Biochemistry. 30: 11046-54. PMID 1834173 DOI: 10.1021/Bi00110A006  0.554
1991 Cowart M, Benkovic SJ, Nash HA. Behavior of a cross-linked attachment site: testing the role of branch migration in site-specific recombination. Journal of Molecular Biology. 220: 621-9. PMID 1831237 DOI: 10.1016/0022-2836(91)90105-F  0.311
1991 Onishi A, Liotta LJ, Benkovic SJ. Cloning and expression of Chromobacterium violaceum phenylalanine hydroxylase in Escherichia coli and comparison of amino acid sequence with mammalian aromatic amino acid hydroxylases. The Journal of Biological Chemistry. 266: 18454-9. PMID 1655752  0.721
1991 Dahlberg ME, Benkovic SJ. Kinetic mechanism of DNA polymerase I (Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant. Biochemistry. 30: 4835-43. PMID 1645180 DOI: 10.1021/Bi00234A002  0.354
1991 Janda KD, Benkovic SJ, McLeod DA, Schloeder DM, Lerner RA. Substrate attenuation: An approach to improve antibody catalysis Tetrahedron. 47: 2503-2506. DOI: 10.1016/S0040-4020(01)81784-1  0.502
1991 Inglese J, Benkovic SJ. Multisubstrate adduct inhibitors of glycinamide ribonucleotide transformylase: Synthetic and enzyme-assembled. Tetrahedron. 47: 2351-2364. DOI: 10.1016/S0040-4020(01)81773-7  0.338
1990 Roberts VA, Iverson BL, Iverson SA, Benkovic SJ, Lerner RA, Getzoff ED, Tainer JA. Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket. Proceedings of the National Academy of Sciences of the United States of America. 87: 6654-8. PMID 2395868 DOI: 10.1073/Pnas.87.17.6654  0.498
1990 Falzone CJ, Benkovic SJ, Wright PE. Partial 1H NMR assignments of the Escherichia coli dihydrofolate reductase complex with folate: Eividence for a unique conformation of bound folate Biochemistry. 29: 9667-9677. PMID 2271608 DOI: 10.1021/Bi00493A023  0.311
1990 Benkovic SJ, Adams JA, Borders CL, Janda KD, Lerner RA. The enzymic nature of antibody catalysis: development of multistep kinetic processing. Science (New York, N.Y.). 250: 1135-9. PMID 2251500 DOI: 10.1126/Science.2251500  0.522
1990 Inglese J, Smith JM, Benkovic SJ. Active-site mapping and site-specific mutagenesis of glycinamide ribonucleotide transformylase from Escherichia coli. Biochemistry. 29: 6678-87. PMID 2204419 DOI: 10.1021/Bi00480A018  0.337
1990 Catalano CE, Allen DJ, Benkovic SJ. Interaction of Escherichia coli DNA polymerase I with azidoDNA and fluorescent DNA probes: identification of protein-DNA contacts. Biochemistry. 29: 3612-21. PMID 2187527 DOI: 10.1021/Bi00467A004  0.415
1990 Thillet J, Adams JA, Benkovic SJ. The kinetic mechanism of wild-type and mutant mouse dihydrofolate reductases. Biochemistry. 29: 5195-202. PMID 1974147 DOI: 10.1021/Bi00473A028  0.362
1990 Wagner CR, Benkovic SJ. Site directed mutagenesis: a tool for enzyme mechanism dissection. Trends in Biotechnology. 8: 263-70. PMID 1366735 DOI: 10.1016/0167-7799(90)90189-5  0.571
1990 Janda KD, Weinhouse MI, Schloeder DM, Lerner RA, Benkovic SJ. Bait and switch strategy for obtaining catalytic antibodies with acyl-transfer capabilities Journal of the American Chemical Society. 112: 1274-1275. DOI: 10.1021/Ja00159A074  0.466
1990 Carroll SS, Benkovic SJ. Mechanistic aspects of DNA polymerases: Escherichia coli DNA polymerase I (Klenow fragment) as a paradigm Chemical Reviews. 90: 1291-1307. DOI: 10.1021/Cr00105A011  0.302
1990 Johnson KA, Benkovic SJ. 4 Analysis of Protein Function by Mutagenesis Enzymes. 19: 159-211. DOI: 10.1016/S1874-6047(08)60197-3  0.363
1989 Lerner RA, Benkovic SJ. Principles of antibody catalysis. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 9: 107-12. PMID 3067727 DOI: 10.1002/Bies.950090402  0.516
1989 Pember SO, Johnson KA, Villafranca JJ, Benkovic SJ. Mechanistic studies on phenylalanine hydroxylase from Chromobacterium violaceum. Evidence for the formation of an enzyme-oxygen complex. Biochemistry. 28: 2124-30. PMID 2719947 DOI: 10.1021/Bi00431A024  0.318
1989 Janda KD, Benkovic SJ, Lerner RA. Catalytic antibodies with lipase activity and R or S substrate selectivity. Science (New York, N.Y.). 244: 437-40. PMID 2717936 DOI: 10.1126/Science.2717936  0.485
1989 Inglese J, Blatchly RA, Benkovic SJ. A multisubstrate adduct inhibitor of a purine biosynthetic enzyme with a picomolar dissociation constant. Journal of Medicinal Chemistry. 32: 937-40. PMID 2709379 DOI: 10.1021/Jm00125A002  0.347
1989 Iverson SA, Sastry L, Huse WD, Sorge JA, Benkovic SJ, Lerner RA. A combinatorial system for cloning and expressing the catalytic antibody repertoire in Escherichia coli. Cold Spring Harbor Symposia On Quantitative Biology. 54: 273-81. PMID 2700937 DOI: 10.1101/Sqb.1989.054.01.034  0.467
1989 Allen DJ, Benkovic SJ. Resonance energy transfer measurements between substrate binding sites within the large (Klenow) fragment of Escherichia coli DNA polymerase I. Biochemistry. 28: 9586-93. PMID 2692712 DOI: 10.1021/Bi00451A006  0.363
1989 Adams J, Johnson K, Matthews R, Benkovic SJ. Effects of distal point-site mutations on the binding and catalysis of dihydrofolate reductase from Escherichia coli. Biochemistry. 28: 6611-8. PMID 2675972 DOI: 10.1021/Bi00442A012  0.325
1989 Allen DJ, Darke PL, Benkovic SJ. Fluorescent oligonucleotides and deoxynucleotide triphosphates: preparation and their interaction with the large (Klenow) fragment of Escherichia coli DNA polymerase I. Biochemistry. 28: 4601-7. PMID 2669960 DOI: 10.1021/Bi00437A014  0.332
1989 Catalano CE, Benkovic SJ. Inactivation of DNA polymerase I (Klenow fragment) by adenosine 2′,3′-epoxide 5′-triphosphate: Evidence for the formation of a tight-binding inhibitor Biochemistry. 28: 4374-4382. PMID 2669951 DOI: 10.1021/Bi00436A038  0.401
1989 Murphy DJ, Benkovic SJ. Hydrophobic interactions via mutants of Escherichia coli dihydrofolate reductase: Separation of binding and catalysis Biochemistry. 28: 3025-3031. PMID 2663066 DOI: 10.1021/Bi00433A043  0.337
1989 Cowart M, Gibson KJ, Allen DJ, Benkovic SJ. DNA substrate structural requirements for the exonuclease and polymerase activities of procaryotic and phage DNA polymerases. Biochemistry. 28: 1975-83. PMID 2541768 DOI: 10.1021/Bi00431A004  0.351
1989 Huse WD, Sastry L, Iverson SA, Kang AS, Alting-Mees M, Burton DR, Benkovic SJ, Lerner RA. Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science (New York, N.Y.). 246: 1275-81. PMID 2531466 DOI: 10.1126/Science.2531466  0.477
1989 Andrews J, Fierke CA, Birdsall B, Ostler G, Feeney J, Roberts GC, Benkovic SJ. A kinetic study of wild-type and mutant dihydrofolate reductases from Lactobacillus casei. Biochemistry. 28: 5743-50. PMID 2505841 DOI: 10.1021/Bi00440A007  0.558
1989 Sastry L, Alting-Mees M, Huse WD, Short JM, Sorge JA, Hay BN, Janda KD, Benkovic SJ, Lerner RA. Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: construction of a heavy chain variable region-specific cDNA library. Proceedings of the National Academy of Sciences of the United States of America. 86: 5728-32. PMID 2503822 DOI: 10.1073/Pnas.86.15.5728  0.474
1989 Fierke CA, Benkovic SJ. Probing the functional role of threonine-113 of Escherichia coli dihydrofolate reductase for its effect on turnover efficiency, catalysis, and binding. Biochemistry. 28: 478-86. PMID 2496745 DOI: 10.1021/Bi00428A011  0.565
1989 Benkovic SJ, Adams JA, Fierke CA, Naylor AM. Insights into Enzymic Catalysis from Studies on Dihydrofolate Reductases Pteridines. 1: 37-43. DOI: 10.1515/Pteridines.1989.1.1.37  0.58
1988 Janda KD, Schloeder D, Benkovic SJ, Lerner RA. Induction of an antibody that catalyzes the hydrolysis of an amide bond. Science (New York, N.Y.). 241: 1188-91. PMID 3413482 DOI: 10.1126/Science.3413482  0.485
1988 Benkovic SJ, Napper AD, Lerner RA. Catalysis of a stereospecific bimolecular amide synthesis by an antibody. Proceedings of the National Academy of Sciences of the United States of America. 85: 5355-8. PMID 3399496 DOI: 10.1073/Pnas.85.15.5355  0.508
1988 Taira K, Benkovic SJ. Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase Journal of Medicinal Chemistry. 31: 129-137. PMID 3275776 DOI: 10.1021/Jm00396A019  0.317
1988 Benkovic SJ, Fierke CA, Naylor AM. Insights into enzyme function from studies on mutants of dihydrofolate reductase. Science (New York, N.Y.). 239: 1105-10. PMID 3125607 DOI: 10.1126/Science.3125607  0.575
1988 Kuchta RD, Benkovic P, Benkovic SJ. Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity Biochemistry. 27: 6716-6725. PMID 3058205 DOI: 10.1021/Bi00418A012  0.357
1988 Mizrahi V, Benkovic SJ. The dynamics of DNA polymerase-catalyzed reactions. Advances in Enzymology and Related Areas of Molecular Biology. 61: 437-57. PMID 2833078 DOI: 10.1002/9780470123072.Ch8  0.304
1987 Napper AD, Benkovic SJ, Tramontano A, Lerner RA. A stereospecific cyclization catalyzed by an antibody. Science (New York, N.Y.). 237: 1041-3. PMID 3616626 DOI: 10.1126/Science.3616626  0.504
1987 Fierke CA, Kuchta RD, Johnson KA, Benkovic SJ. Implications for enzymic catalysis from free-energy reaction coordinate profiles. Cold Spring Harbor Symposia On Quantitative Biology. 52: 631-8. PMID 3331348 DOI: 10.1101/Sqb.1987.052.01.072  0.544
1987 Kuchta RD, Mizrahi V, Benkovic PA, Johnson KA, Benkovic SJ. Kinetic mechanism of DNA polymerase I (Klenow) Biochemistry. 26: 8410-8417. PMID 3327522 DOI: 10.1021/Bi00399A057  0.336
1987 Chen JT, Taira K, Tu CP, Benkovic SJ. Probing the functional role of phenylalanine-31 of Escherichia coli dihydrofolate reductase by site-directed mutagenesis. Biochemistry. 26: 4093-100. PMID 3307917 DOI: 10.1021/Bi00387A053  0.361
1987 Fierke CA, Johnson KA, Benkovic SJ. Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli. Biochemistry. 26: 4085-92. PMID 3307916 DOI: 10.1021/Bi00387A052  0.534
1987 Dix TA, Kuhn DM, Benkovic SJ. Mechanism of oxygen activation by tyrosine hydroxylase. Biochemistry. 26: 3354-61. PMID 2888478 DOI: 10.1021/Bi00386A016  0.305
1987 Pember SO, Benkovic SJ, Villafranca JJ, Pasenkiewicz-Gierula M, Antholine WE. Adduct formation between the cupric site of phenylalanine hydroxylase from Chromobacterium violaceum and 6,7-dimethyltetrahydropterin. Biochemistry. 26: 4477-83. PMID 2822093 DOI: 10.1021/Bi00388A045  0.306
1987 Gibson KJ, Benkovic SJ. Synthesis and application of derivatizable oligonucleotides. Nucleic Acids Research. 15: 6455-67. PMID 2442728 DOI: 10.1093/Nar/15.16.6455  0.352
1987 Taira K, Chen J, Fierke CA, Benkovic SJ. Protein Engineering of Dihydrofolate Reductase. pH Dependency of Phe-31 Mutants Bulletin of the Chemical Society of Japan. 60: 3025-3030. DOI: 10.1246/Bcsj.60.3025  0.499
1987 Taira K, Chen J, Mayer RJ, Benkovic SJ. Protein Engineering of Dihydrofolate Reductase. Improved Catalytic Step of Mutant-Enzymes Bulletin of the Chemical Society of Japan. 60: 3017-3024. DOI: 10.1246/Bcsj.60.3017  0.348
1987 Taira K, Fierke CA, Chen J, Johnson KA, Benkovic SJ. On interpreting the inhibition of and catalysis by dihydrofolate reductase Trends in Biochemical Sciences. 12: 275-278. DOI: 10.1016/0968-0004(87)90134-4  0.571
1986 Daubner SC, Schrimsher JL, Schendel FJ, Young M, Henikoff S, Patterson D, Stubbe J, Benkovic SJ. A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis. Biochemistry. 24: 7059-62. PMID 4084560 DOI: 10.1021/Bi00346A006  0.709
1986 Dix TA, Benkovic SJ. Mechanism of "uncoupled" tetrahydropterin oxidation by phenylalanine hydroxylase. Biochemistry. 24: 5839-46. PMID 4084494 DOI: 10.1021/Bi00342A022  0.302
1986 Daubner SC, Young M, Sammons RD, Courtney LF, Benkovic SJ. Structural and mechanistic studies on the HeLa and chicken liver proteins that catalyze glycinamide ribonucleotide synthesis and formylation and aminoimidazole ribonucleotide synthesis. Biochemistry. 25: 2951-7. PMID 3718932 DOI: 10.1021/Bi00358A033  0.707
1986 Mizrahi V, Benkovic PA, Benkovic SJ. Mechanism of the idling-turnover reaction of the large (Klenow) fragment of Escherichia coli DNA polymerase I. Proceedings of the National Academy of Sciences of the United States of America. 83: 231-5. PMID 3510431 DOI: 10.1073/Pnas.83.2.231  0.343
1986 Mayer RJ, Chen JT, Taira K, Fierke CA, Benkovic SJ. Importance of a hydrophobic residue in binding and catalysis by dihydrofolate reductase. Proceedings of the National Academy of Sciences of the United States of America. 83: 7718-20. PMID 3463995 DOI: 10.1073/Pnas.83.20.7718  0.561
1986 Pember SO, Villafranca JJ, Benkovic SJ. Phenylalanine hydroxylase from Chromobacterium violaceum is a copper-containing monooxygenase. Kinetics of the reductive activation of the enzyme. Biochemistry. 25: 6611-9. PMID 3024714 DOI: 10.1021/Bi00369A042  0.357
1986 Mizrahi V, Benkovic P, Benkovic SJ. Mechanism of DNA polymerase I: exonuclease/polymerase activity switch and DNA sequence dependence of pyrophosphorolysis and misincorporation reactions. Proceedings of the National Academy of Sciences of the United States of America. 83: 5769-73. PMID 3016719 DOI: 10.1073/Pnas.83.16.5769  0.357
1986 Zydowsky TM, Courtney LF, Frasca V, Kobayashi K, Shimizu H, Yuen LD, Matthews RG, Benkovic SJ, Floss HG. Stereochemical analysis of the methyl transfer catalyzed by cobalamin-dependent methionine synthase from Escherichia coli B Journal of the American Chemical Society. 108: 3152-3153. DOI: 10.1021/ja00271a081  0.484
1986 Noar JB, Venkataram UV, Bruice TC, Bollag G, Whittle R, Sammons D, Henry R, Benkovic SJ. The reaction of nucleophilic species with quinonoid 6,6,7,7-tetramethyldihydropterin Bioorganic Chemistry. 14: 17-27. DOI: 10.1016/0045-2068(86)90014-3  0.45
1985 Chen JT, Mayer RJ, Fierke CA, Benkovic SJ. Site-specific mutagenesis of dihydrofolate reductase from Escherichia coli. Journal of Cellular Biochemistry. 29: 73-82. PMID 3905833 DOI: 10.1002/Jcb.240290203  0.56
1985 Mizrahi V, Henrie RN, Marlier JF, Johnson KA, Benkovic SJ. Rate-limiting steps in the DNA polymerase I reaction pathway. Biochemistry. 24: 4010-8. PMID 3902078 DOI: 10.1021/Bi00336A031  0.325
1985 EBERLEIN G, BRUICE TC, LAZARUS RA, HENRIE R, BENKOVIC SJ. ChemInform Abstract: THE INTERCONVERSION OF THE 5,6,7,8-TETRAHYDRO-, 6,7,8-DIHYDRO-, AND RADICAL FORMS OF 6,6,7,7-TETRAMETHYLDIHYDROPTERIN. A MODEL FOR THE BIOPTERIN CENTER OF AROMATIC AMINO ACID MIXED FUNCTION OXIDASES Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198515148  0.442
1984 Young M, Sammons RD, Mueller WT, Benkovic SJ. An antibody probe to determine the native species of glycinamide ribonucleotide transformylase in chicken liver. Biochemistry. 23: 3979-86. PMID 6386041 DOI: 10.1021/Bi00312A027  0.311
1984 Wasserman GF, Mueller WT, Benkovic SJ, Liao WS, Taylor J. Evidence that the folate-requiring enzymes of de novo purine biosynthesis are encoded by individual mRNAs. Biochemistry. 23: 6704-10. PMID 6335666 DOI: 10.1021/Bi00321A065  0.354
1984 Wallick DE, Bloom LM, Gaffney BJ, Benkovic SJ. Reductive activation of phenylalanine hydroxylase and its effect on the redox state of the non-heme iron. Biochemistry. 23: 1295-302. PMID 6324864 DOI: 10.1021/Bi00301A043  0.327
1984 Gupta AP, Benkovic PA, Benkovic SJ. The effect of the 3',5' thiophosphoryl linkage on the exonuclease activities of T4 polymerase and the Klenow fragment. Nucleic Acids Research. 12: 5897-911. PMID 6087297 DOI: 10.1093/Nar/12.14.5897  0.344
1984 Benkovic SJ. The transformylase enzymes in de novo purine biosynthesis Trends in Biochemical Sciences. 9: 320-322. DOI: 10.1042/Bst028A122C  0.325
1984 Eberlein G, Bruice TC, Lazarus RA, Henrie R, Benkovic SJ. The interconversion of the 5,6,7,8-tetrahydro-, 6,7,8-dihydro-, and radical forms of 6,6,7,7-tetramethyldihydropterin. A model for the biopterin center of aromatic amino acid mixed function oxidases Journal of the American Chemical Society. 106: 7916-7924. DOI: 10.1021/Ja00337A047  0.44
1983 Bryant FR, Johnson KA, Benkovic SJ. Elementary steps in the DNA polymerase I reaction pathway Biochemistry. 22: 3537-3546. PMID 6351905 DOI: 10.1021/Bi00284A001  0.358
1982 Shortle D, Grisafi P, Benkovic SJ, Botstein D. Gap misrepair mutagenesis: Efficient site-directed induction of transition, transversion, and frameshift mutations in vitro Proceedings of the National Academy of Sciences of the United States of America. 79: 1588-1592. PMID 7041125 DOI: 10.1073/Pnas.79.5.1588  0.32
1982 Putney SD, Benkovic SJ, Schimmel PR. A DNA fragment with an alpha-phosphorothioate nucleotide at one end is asymmetrically blocked from digestion by exonuclease III and can be replicated in vivo. Proceedings of the National Academy of Sciences of the United States of America. 78: 7350-4. PMID 6278470 DOI: 10.1073/Pnas.78.12.7350  0.315
1981 Lazarus RA, Dietrich RF, Wallick DE, Benkovic SJ. On the mechanism of action of phenylalanine hydroxylase. Biochemistry. 20: 6834-41. PMID 7317357 DOI: 10.1021/Bi00527A015  0.32
1981 Caperelli CA, Domanico P, Benkovic SJ. Synthesis of 5,11-methenyltetrahydrohomofolate and its antifolate activity in vitro. Journal of Medicinal Chemistry. 24: 1086-8. PMID 7288824 DOI: 10.1002/Chin.198206208  0.359
1981 Marlier JF, Bryant FR, Benkovic SJ. Stereochemical and kinetic investigation of 32P-labeled inorganic phosphate exchange reaction catalyzed by primer-independent and primer-dependent polynucleotide phosphorylase from Micrococcus luteus Biochemistry. 20: 2212-2219. PMID 7236593 DOI: 10.1021/Bi00511A022  0.324
1981 Cunningham BA, Raushel FM, Villafranca JJ, Benkovic SJ. Distances between structural metal ion, substrates, and allosteric modifier of fructose bisphosphatase. Biochemistry. 20: 359-62. PMID 6258638 DOI: 10.1021/Bi00505A020  0.302
1981 Demaine MM, Benkovic SJ. Selective modification of rabbit liver fructose bisphosphatase. Archives of Biochemistry and Biophysics. 205: 308-14. PMID 6258480 DOI: 10.1016/0003-9861(80)90112-5  0.345
1980 Smith GK, Mueller WT, Wasserman GF, Taylor WD, Benkovic SJ. Characterization of the enzyme complex involving the folate-requiring enzymes of de novo purine biosynthesis. Biochemistry. 19: 4313-21. PMID 7417406 DOI: 10.1021/Bi00559A026  0.333
1980 Benkovic SJ. Anomeric specificity of carbohydrate-utilizing enzymes. Methods in Enzymology. 63: 370-9. PMID 502861 DOI: 10.1016/0076-6879(79)63016-1  0.332
1980 MOAD G, LUTHY CL, BENKOVIC PA, BENKOVIC SJ. ChemInform Abstract: STUDIES ON 6-METHYL-5-DEAZATETRAHYDROPTERIN AND ITS 4A ADDUCTS Chemischer Informationsdienst. 11. DOI: 10.1002/chin.198003292  0.415
1979 Lazarus RA, Benkovic PA, Benkovic SJ. The synthesis and properties in enzymic reactions of substrate analogs containing the methylphosphonyl group. Archives of Biochemistry and Biophysics. 197: 218-25. PMID 232398 DOI: 10.1016/0003-9861(79)90239-X  0.3
1979 Bryant FR, Benkovic SJ. Stereochemical course of the reaction catalyzed by 5′-nucleotide phosphodiesterase from snake venom Biochemistry. 18: 2825-2828. PMID 224905 DOI: 10.1021/Bi00580A022  0.341
1979 deMaine MM, Benkovic SJ. Kinetic hysteresis for fructose bisphosphatase: a change in substrate configuration specificity. Biochemical and Biophysical Research Communications. 88: 835-40. PMID 223573 DOI: 10.1016/0006-291X(79)91484-0  0.331
1979 Benkovic PA, Frey WA, Benkovic SJ. The binding of products, metal ion, and a substrate analog to rabbit liver fructose bisphosphatase. Archives of Biochemistry and Biophysics. 191: 719-26. PMID 217310 DOI: 10.1016/0003-9861(78)90412-5  0.318
1979 Benkovic PA, Hegazi M, Cunningham BA, Benkovic SJ. Investigation of the pre-steady-state kinetics of fructose bisphosphatase by employment of an indicator method. Biochemistry. 18: 830-6. PMID 33703 DOI: 10.1021/Bi00572A014  0.351
1979 Moad G, Luthy CL, Benkovic PA, Benkovic SJ. Studies on 6-methyl-5-deazatetrahydropterin and its 4a adducts Journal of the American Chemical Society. 101: 6068-6076. DOI: 10.1021/Ja00514A033  0.475
1978 Benkovic PA, Caperelli CA, de Maine M, Benkovic SJ. Binding and kinetic data for rabbit liver fructose-1,6-bisphosphatase with Zn2+ as cofactor. Proceedings of the National Academy of Sciences of the United States of America. 75: 2185-9. PMID 209458 DOI: 10.1073/Pnas.75.5.2185  0.311
1978 Moad G, Benkovic SJ. On the mechanism of decomposition of geminal diamines Journal of the American Chemical Society. 100: 5495-5499. DOI: 10.1021/Ja00485A038  0.488
1978 Schray KJ, Benkovic SJ. Anomerization rates and enzyme specificity for biologically important sugars and sugar phosphates Accounts of Chemical Research. 11: 136-141. DOI: 10.1021/Ar50124A002  0.326
1978 Moad G, Luthy CL, Benkovic SJ. The mechanism of oxidation of 6-methyl-5-carba-5-deazatetrahydropterin. Evidence for the involvement cf a 4a-adduct in the oxidation of tetrahydropterins Tetrahedron Letters. 19: 2271-2274. DOI: 10.1016/S0040-4039(01)91510-2  0.478
1978 MOAD G, BENKOVIC SJ. ChemInform Abstract: ON THE MECHANISM OF DECOMPOSITION OF GEMINAL DIAMINES Chemischer Informationsdienst. 9. DOI: 10.1002/chin.197848105  0.431
1978 MOAD G, LUTHY CL, BENKOVIC SJ. ChemInform Abstract: THE MECHANISM OF OXIDATION OF 6-METHYL-5-CARBA-5-DEAZATETRAHYDROPTERIN. EVIDENCE FOR THE INVOLVEMENT OF A 4A-ADDUCT IN THE OXIDATION OF TETRAHYDROPTERINS Chemischer Informationsdienst. 9. DOI: 10.1002/chin.197841219  0.419
1977 Tatum CM, Benkovic PA, Benkovic SJ, Potts R, Schleicher E, Floss HG. Stereochemistry of methylene transfer involving 5,10-methylenetetrahydrofolate. Biochemistry. 16: 1093-102. PMID 849409 DOI: 10.1021/Bi00625A010  0.307
1977 Schirch LV, Tatum CM, Benkovic SJ. Serine transhydroxymethylase: evidence for a sequential random mechanism. Biochemistry. 16: 410-9. PMID 836793 DOI: 10.1021/Bi00622A011  0.312
1977 Dudman NP, Benkovic SJ. Novel phosphonothioate substrates for phosphodiesterases. Journal of the American Chemical Society. 99: 6113-5. PMID 197138 DOI: 10.1002/Chin.197749288  0.301
1977 Frey WA, Fishbein R, de Maine MM, Benkovic SJ. Substrate form of D-frutose 1,6-bisphosphate utilized by fructose 1,6-bisphosphatase. Biochemistry. 16: 2479-84. PMID 193561 DOI: 10.1021/Bi00630A025  0.328
1977 Benkovic SJ, Tatum CM. Mechanisms of folate cofactors Trends in Biochemical Sciences. 2: 161-163. DOI: 10.1016/0968-0004(77)90366-8  0.304
1976 Amato BA, Benkovic SJ. The mechanism of formylation of five-membered cyclic phosphorodiamidates. Biochemistry. 14: 4877-87. PMID 241391 DOI: 10.1021/Bi00693A015  0.316
1976 Benkovic SJ, Schray KJ. The anomeric specificity of glycolytic enzymes. Advances in Enzymology and Related Areas of Molecular Biology. 44: 139-64. PMID 132111 DOI: 10.1002/9780470122891.Ch4  0.327
1975 Sampson EJ, Vergara EV, Fedor JM, Funk MO, Benkovic SJ. On the physical properties and mechanism of action of arylsulfate sulfohydrolase II from Aspergillus oryzae. Archives of Biochemistry and Biophysics. 169: 372-83. PMID 241293 DOI: 10.1016/0003-9861(75)90178-2  0.378
1974 Benkovic SJ, Frey WA, Libby CB, Villafranca JJ. The role of tryptophan in neutral fructose diphosphatase. Biochemical and Biophysical Research Communications. 57: 196-203. PMID 4364002 DOI: 10.1016/S0006-291X(74)80376-1  0.345
1973 Benkovic S, Schray KJ. 6 Chemical Basis of Biological Phosphoryl Transfer The Enzymes. 8: 201-238. DOI: 10.1016/S1874-6047(08)60066-9  0.328
1972 De Maine MM, Benkovic SJ. On the mechanism of alkaline and neutral fructose 1, 6-diphosphatase: inhibition by substrate analogs at neutral pH. Archives of Biochemistry and Biophysics. 152: 272-9. PMID 4342110 DOI: 10.1016/0003-9861(72)90215-9  0.303
1969 Hegarty AF, Bruice TC, Benkovic SJ. Biotin and the nucleophilicity of 2-methoxy-2-imidazoline toward the sp2 carbonyl carbon Journal of the Chemical Society D: Chemical Communications. 1173-1174. DOI: 10.1039/C29690001173  0.394
1965 French TC, Benkovic SJ, Bruice TC. Stopped‐Flow Apparatus for a Zeiss PMQ II Spectrophotometer Review of Scientific Instruments. 36: 860-861. DOI: 10.1063/1.1719734  0.381
1964 Bruice TC, Benkovic SJ. The Compensation in ΔH[UNK] and ΔS[UNK] Accompanying the Conversion of Lower Order Nucleophilic Displacement Reactions to Higher Order Catalytic Processes. The Temperature Dependence of the Hydrazinolysis and Imidazole-Catalyzed Hydrolysis of Substituted Phenyl Acetates Journal of the American Chemical Society. 86: 418-426. DOI: 10.1021/Ja01057A026  0.45
1963 Bruice TC, Benkovic SJ. A Comparison of the Bimolecular and Intramolecular Nucleophilic Catalysis of the Hydrolysis of Substituted Phenyl Acylates by the Dimethylamino Group Journal of the American Chemical Society. 85: 1-8. DOI: 10.1021/Ja00884A001  0.446
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