cached image

Donald M. Hilvert - Publications

Affiliations: 
Eidgenössische Technische Hochschule Zürich, Zürich, ZH, Switzerland 
Area:
chemical biology
Website:
http://www.protein.ethz.ch/hilvert.html

260 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Macdonald DS, Hilvert D. Enhancing promiscuous chemistries of a Schiff-base forming enzyme by divergent evolution. Methods in Enzymology. 644: 95-120. PMID 32943152 DOI: 10.1016/Bs.Mie.2020.06.014  1
2020 Tinzl M, Hilvert D. Trapping transient protein species by genetic code expansion Chembiochem. PMID 32810341 DOI: 10.1002/Cbic.202000523  1
2020 Russ WP, Figliuzzi M, Stocker C, Barrat-Charlaix P, Socolich M, Kast P, Hilvert D, Monasson R, Cocco S, Weigt M, Ranganathan R. An evolution-based model for designing chorismate mutase enzymes. Science (New York, N.Y.). 369: 440-445. PMID 32703877 DOI: 10.1126/Science.Aba3304  1
2020 Macdonald DS, Garrabou X, Klaus C, Verez R, Mori T, Hilvert D. Engineered artificial carboligases facilitate regioselective preparation of enantioenriched aldol adducts. Journal of the American Chemical Society. PMID 32427470 DOI: 10.1021/Jacs.0C02351  1
2020 Kries H, Bloch JS, Bunzel HA, Pinkas DM, Hilvert D. Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiencyproficiency Acs Catalysis. DOI: 10.2210/Pdb6Sry/Pdb  1
2020 Kries H, Bloch JS, Bunzel HA, Pinkas DM, Hilvert D. Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiency Acs Catalysis. 10: 4460-4464. DOI: 10.1021/Acscatal.0C00575  1
2019 Tytgat HLP, Lin CW, Levasseur MD, Tomek MB, Rutschmann C, Mock J, Liebscher N, Terasaka N, Azuma Y, Wetter M, Bachmann MF, Hilvert D, Aebi M, Keys TG. Cytoplasmic glycoengineering enables biosynthesis of nanoscale glycoprotein assemblies. Nature Communications. 10: 5403. PMID 31776333 DOI: 10.1038/S41467-019-13283-2  1
2019 Weitzner BD, Kipnis Y, Daniel AG, Hilvert D, Baker D. A computational method for design of connected catalytic networks in proteins. Protein Science : a Publication of the Protein Society. PMID 31642127 DOI: 10.1002/Pro.3757  1
2019 Greisch JF, Tamara S, Scheltema RA, Maxwell HWR, Fagerlund RD, Fineran PC, Tetter S, Hilvert D, Heck AJR. Expanding the mass range for UVPD-based native top-down mass spectrometry. Chemical Science. 10: 7163-7171. PMID 31588283 DOI: 10.1039/C9Sc01857C  1
2019 Sasaki E, Dragoman RM, Mantri S, Dirin DN, Kovalenko MV, Hilvert D. Self-Assembly of Proteinaceous Shells Around Positively Charged Gold Nanomaterials Enhances Colloidal Stability in High Ionic Strength Buffers. Chembiochem : a European Journal of Chemical Biology. PMID 31523885 DOI: 10.1002/Cbic.201900469  1
2019 Fábregas Ibáñez L, Soetbeer J, Klose D, Tinzl M, Hilvert D, Jeschke G. Non-uniform HYSCORE: Measurement, processing and analysis with Hyscorean. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 307: 106576. PMID 31450188 DOI: 10.1016/J.Jmr.2019.106576  1
2019 Bunzel HA, Kries H, Marchetti L, Zeymer C, Mittl P, Mulholland AJ, Hilvert D. Emergence of a negative activation heat capacity during evolution of a designed enzyme. Journal of the American Chemical Society. PMID 31282667 DOI: 10.1021/Jacs.9B02731  1
2019 Edwardson TGW, Hilvert D. Virus-Inspired Function in Engineered Protein Cages. Journal of the American Chemical Society. 141: 9432-9443. PMID 31117660 DOI: 10.1021/Jacs.9B03705  1
2019 Sasaki E, Hilvert D. [Structure and Self-assembly of Negatively Supercharged Protein Cages]. Yakugaku Zasshi-Journal of the Pharmaceutical Society of Japan. 139: 199-208. PMID 30713229 DOI: 10.1248/Yakushi.18-00169-2  1
2019 Niquille DL, Hansen DA, Hilvert D. Reprogramming Nonribosomal Peptide Synthesis by Surgical Mutation Synlett. 30: 2123-2130. DOI: 10.1055/S-0039-1690711  1
2019 Grogg M, Hilvert D, Beck AK, Seebach D. Syntheses of Cyanophycin Segments for Investigations of Cell-Penetration Synthesis. 51: 31-39. DOI: 10.1055/S-0037-1610202  1
2018 Grogg M, Hilvert D, Ebert MO, Beck AK, Seebach D, Kurth F, Dittrich PS, Sparr C, Wittlin S, Rottmann M, Mäser P. Cell Penetration, Herbicidal Activity, and -Toxicity of Oligo-Arginine Derivatives and of Novel Guanidinium-Rich Compounds Derived from the Biopolymer Cyanophycin. Helvetica Chimica Acta. 101. PMID 30905972 DOI: 10.1002/Hlca.201800112  1
2018 Studer S, Hansen DA, Pianowski ZL, Mittl PRE, Debon A, Guffy SL, Der BS, Kuhlman B, Hilvert D. Evolution of a highly active and enantiospecific metalloenzyme from short peptides. Science (New York, N.Y.). 362: 1285-1288. PMID 30545884 DOI: 10.1126/Science.Aau3744  1
2018 Edwardson TGW, Mori T, Hilvert D. Rational Engineering of a Designed Protein Cage for siRNA Delivery. Journal of the American Chemical Society. 140: 10439-10442. PMID 30091604 DOI: 10.1021/Jacs.8B06442  1
2018 Azuma Y, Hilvert D. Enzyme Encapsulation in an Engineered Lumazine Synthase Protein Cage Methods of Molecular Biology. 1798: 39-55. PMID 29868950 DOI: 10.1007/978-1-4939-7893-9_4  1
2018 Hayashi T, Hilvert D, Green AP. Engineered Metalloenzymes with Non-Canonical Coordination Environments. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29786902 DOI: 10.1002/Chem.201800975  1
2018 Terasaka N, Azuma Y, Hilvert D. Laboratory evolution of virus-like nucleocapsids from nonviral protein cages. Proceedings of the National Academy of Sciences of the United States of America. 115: 5432-5437. PMID 29735682 DOI: 10.1073/Pnas.1800527115  1
2018 Azuma Y, Edwardson TGW, Hilvert D. Tailoring lumazine synthase assemblies for bionanotechnology Chemical Society Reviews. 47: 3543-3557. PMID 29714396 DOI: 10.1039/C8Cs00154E  1
2018 Zeymer C, Hilvert D. Directed Evolution of Protein Catalysts. Annual Review of Biochemistry. 87: 131-157. PMID 29494241 DOI: 10.1146/Annurev-Biochem-062917-012034  1
2018 Niquille DL, Hansen DA, Mori T, Fercher D, Kries H, Hilvert D. Nonribosomal biosynthesis of backbone-modified peptides. Nature Chemistry. 10: 282-287. PMID 29461527 DOI: 10.1038/Nchem.2891  1
2018 Garrabou Pi X, Macdonald DS, Wicky BIM, Hilvert D. Stereodivergent Evolution of Artificial Enzymes for the Michael Reaction. Angewandte Chemie (International Ed. in English). PMID 29446221 DOI: 10.1002/Anie.201712554  1
2018 Bunzel HA, Garrabou X, Pott M, Hilvert D. Speeding up enzyme discovery and engineering with ultrahigh-throughput methods. Current Opinion in Structural Biology. 48: 149-156. PMID 29413955 DOI: 10.1016/J.Sbi.2017.12.010  1
2018 Pott M, Hayashi T, Mori T, Mittl PRE, Green AP, Hilvert D. A Non-Canonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold. Journal of the American Chemical Society. PMID 29309143 DOI: 10.1021/Jacs.7B12621  1
2018 Azuma Y, Edwardson TGW, Terasaka N, Hilvert D. Modular Protein Cages for Size-Selective RNA Packaging in Vivo Journal of the American Chemical Society. 140: 566-569. PMID 29278497 DOI: 10.1021/Jacs.7B10798  1
2018 Azuma Y, Bader DLV, Hilvert D. Substrate Sorting by a Supercharged Nanoreactor Journal of the American Chemical Society. 140: 860-863. PMID 29278496 DOI: 10.1021/Jacs.7B11210  1
2018 Azuma Y, Herger M, Hilvert D. Diversification of Protein Cage Structure Using Circularly Permuted Subunits Journal of the American Chemical Society. 140: 558-561. PMID 29257675 DOI: 10.1021/Jacs.7B10513  1
2018 Hayashi T, Hilvert D, Green AP. Frontispiece: Engineered Metalloenzymes with Non‐Canonical Coordination Environments Chemistry – a European Journal. 24. DOI: 10.1002/Chem.201884661  0.04
2017 Dragoman RM, Grogg M, Bodnarchuk MI, Tiefenboeck P, Hilvert D, Dirin DN, Kovalenko MV. Surface-Engineered Cationic Nanocrystals Stable in Biological Buffers and High Ionic Strength Solutions. Chemistry of Materials : a Publication of the American Chemical Society. 29: 9416-9428. PMID 29606797 DOI: 10.1021/Acs.Chemmater.7B03504  1
2017 Fort KL, van de Waterbeemd M, Boll D, Reinhardt-Szyba M, Belov ME, Sasaki E, Zschoche R, Hilvert D, Makarov AA, Heck AJR. Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes. The Analyst. PMID 29138777 DOI: 10.1039/C7An01629H  1
2017 Tetter S, Hilvert D. Enzyme Encapsulation by a Ferritin Cage Angewandte Chemie. 56: 14933-14936. PMID 28902449 DOI: 10.1002/Anie.201708530  1
2017 Obexer R, Pott M, Zeymer C, Griffiths AD, Hilvert D. Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting. Protein Engineering, Design & Selection : Peds. 30: 531. PMID 28873983 DOI: 10.1093/Protein/Gzx032  1
2017 Zeymer C, Zschoche R, Hilvert D. Optimization of Enzyme Mechanism along the Evolutionary Trajectory of a Computationally Designed (Retro-)Aldolase Journal of the American Chemical Society. 139: 12541-12549. PMID 28783336 DOI: 10.1021/Jacs.7B05796  1
2017 Dince CC, Meoded RA, Hilvert D. Synthesis and characterization of catalytically active thiazolium gold(I)-carbenes Chemical Communications. 53: 7585-7587. PMID 28638911 DOI: 10.1039/C7Cc03791K  0.08
2017 Azuma Y, Zschoche R, Hilvert D. The C-terminal peptide of Aquifex aeolicus riboflavin synthase directs encapsulation of native and foreign guests by a cage-forming lumazine synthase Journal of Biological Chemistry. 292: 10321-10327. PMID 28515315 DOI: 10.1074/Jbc.C117.790311  1
2017 Sasaki E, Böhringer D, van de Waterbeemd M, Leibundgut M, Zschoche R, Heck AJ, Ban N, Hilvert D. Structure and assembly of scalable porous protein cages. Nature Communications. 8: 14663. PMID 28281548 DOI: 10.1038/Ncomms14663  1
2017 Václavík J, Zschoche R, Klimánková I, Matoušek V, Beier P, Hilvert D, Togni A. Irreversible Cysteine-Selective Protein Labeling Employing Modular Electrophilic Tetrafluoroethylation Reagents. Chemistry (Weinheim An Der Bergstrasse, Germany). 23: 6490-6494. PMID 28195376 DOI: 10.1002/Chem.201700607  1
2017 Garrabou Pi X, Macdonald DS, Hilvert D. Chemoselective Henry condensations catalyzed by artificial carboligases. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28070900 DOI: 10.1002/Chem.201605757  1
2017 Obexer R, Godina A, Garrabou X, Mittl PR, Baker D, Griffiths AD, Hilvert D. Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase. Nature Chemistry. 9: 50-56. PMID 27995916 DOI: 10.1038/Nchem.2596  1
2017 Garrabou X, Verez R, Hilvert D. Enantiocomplementary Synthesis of γ-Nitroketones Using Designed and Evolved Carboligases. Journal of the American Chemical Society. 139: 103-106. PMID 27992715 DOI: 10.1021/Jacs.6B11928  1
2017 Root K, Frey R, Hilvert D, Zenobi R. High-Mass MALDI-MS Analysis for the Investigation of Protein Encapsulation within an Engineered Capsid Forming Protein Helvetica Chimica Acta. 100. DOI: 10.1002/Hlca.201700166  1
2017 Václavík J, Zschoche R, Klimánková I, Matoušek V, Beier P, Hilvert D, Togni A. Inside Cover: Irreversible Cysteine‐Selective Protein Labeling Employing Modular Electrophilic Tetrafluoroethylation Reagents (Chem. Eur. J. 27/2017) Chemistry: a European Journal. 23: 6462-6462. DOI: 10.1002/Chem.201701036  1
2016 Obexer R, Pott M, Zeymer C, Griffiths AD, Hilvert D. Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting. Protein Engineering, Design & Selection : Peds. PMID 27542390 DOI: 10.1093/Protein/Gzw032  1
2016 Liu Z, Lebrun V, Kitanosono T, Mallin H, Köhler V, Häussinger D, Hilvert D, Kobayashi S, Ward TR. Upregulation of an Artificial Zymogen by Proteolysis. Angewandte Chemie (International Ed. in English). PMID 27529471 DOI: 10.1002/Anie.201605010  1
2016 Green AP, Hayashi T, Mittl PR, Hilvert D. A Chemically Programmed Proximal Ligand Enhances the Catalytic Properties of a Heme Enzyme. Journal of the American Chemical Society. PMID 27500802 DOI: 10.1021/Jacs.6B07029  1
2016 Frey R, Hayashi T, Hilvert D. Enzyme-mediated polymerization inside engineered protein cages. Chemical Communications. 52: 10423-10426. PMID 27484787 DOI: 10.1039/C6Cc05301G  1
2016 Frey R, Mantri S, Rocca M, Hilvert D. Bottom-up Construction of a Primordial Carboxysome Mimic. Journal of the American Chemical Society. 138: 10072-10075. PMID 27479274 DOI: 10.1021/Jacs.6B04744  1
2016 MacDonald MJ, Lavis LD, Hilvert D, Gellman SH. Evaluation of the Ser-His Dipeptide, a Putative Catalyst of Amide and Ester Hydrolysis. Organic Letters. PMID 27400366 DOI: 10.1021/Acs.Orglett.6B01279  1
2016 Garrabou X, Wicky BIM, Hilvert D. Fast Knoevenagel Condensations Catalyzed by an Artificial Schiff-Base-Forming Enzyme. Journal of the American Chemical Society. 138: 6972-6974. PMID 27196438 DOI: 10.1021/Jacs.6B00816  1
2016 Heinze K, Sasaki E, King NP, Baker D, Hilvert D, Wuite GJ, Roos WH. Protein Nanocontainers from Nonviral Origin: Testing the Mechanics of Artificial and Natural Protein Cages by AFM. The Journal of Physical Chemistry. B. PMID 27187612 DOI: 10.1021/Acs.Jpcb.6B01464  1
2016 Sasaki E, Hilvert D. Self-Assembly of Proteinaceous Multishell Structures Mediated by a Supercharged Protein Journal of Physical Chemistry B. 120: 6089-6095. PMID 27064167 DOI: 10.1021/Acs.Jpcb.6B02068  1
2016 Torbeev V, Grogg M, Ruiz J, Boehringer R, Schirer A, Hellwig P, Jeschke G, Hilvert D. Chiral recognition in amyloid fiber growth. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 26929241 DOI: 10.1002/Psc.2861  1
2016 Galinis R, Stonyte G, Kiseliovas V, Zilionis R, Studer S, Hilvert D, Janulaitis A, Mazutis L. DNA Nanoparticles for Improved Protein Synthesis In Vitro Angewandte Chemie. 55: 3120-3123. PMID 26821778 DOI: 10.1002/Anie.201511809  1
2016 Azuma Y, Zschoche R, Tinzl M, Hilvert D. Quantitative Packaging of Active Enzymes into a Protein Cage. Angewandte Chemie (International Ed. in English). 55: 1531-4. PMID 26695342 DOI: 10.1002/Anie.201508414  1
2016 Azuma Y, Zschoche R, Tinzl M, Hilvert D. Quantitative Beladung eines Proteinkäfigs mit aktiven Enzymen Angewandte Chemie. 128: 1555-1558. DOI: 10.1002/Ange.201508414  1
2015 Metanis N, Hilvert D. Harnessing selenocysteine reactivity for oxidative protein folding. Chemical Science. 6: 322-325. PMID 28757941 DOI: 10.1039/C4Sc02379J  1
2015 Schulz JD, Patt M, Basler S, Kries H, Hilvert D, Gauthier MA, Leroux JC. Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract. Advanced Materials (Deerfield Beach, Fla.). PMID 26640034 DOI: 10.1002/Adma.201504797  1
2015 Zschoche R, Hilvert D. Diffusion-Limited Cargo Loading of an Engineered Protein Container. Journal of the American Chemical Society. 137: 16121-32. PMID 26637019 DOI: 10.1021/Jacs.5B10588  1
2015 Vandemeulebroucke A, Aldag C, Stiebritz MT, Reiher M, Hilvert D. Kinetic consequences of introducing a proximal selenocysteine ligand into cytochrome P450cam. Biochemistry. 54: 6692-703. PMID 26460790 DOI: 10.1021/Acs.Biochem.5B00939  1
2015 Kries H, Niquille DL, Hilvert D. A Subdomain Swap Strategy for Reengineering Nonribosomal Peptides Chemistry & Biology. 22: 640-648. PMID 26000750 DOI: 10.1016/J.Chembiol.2015.04.015  1
2015 Garrabou X, Beck T, Hilvert D. A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates. Angewandte Chemie (International Ed. in English). 54: 5609-12. PMID 25777153 DOI: 10.1002/Anie.201500217  1
2015 Schulenburg C, Stark Y, Künzle M, Hilvert D. Comparative laboratory evolution of ordered and disordered enzymes. Journal of Biological Chemistry. 290: 9310-9320. PMID 25697360 DOI: 10.1074/Jbc.M115.638080  1
2015 Torbeev V, Ebert MO, Dolenc J, Hilvert D. Substitution of proline32 by α-methylproline preorganizes β2-microglobulin for oligomerization but not for aggregation into amyloids. Journal of the American Chemical Society. 137: 2524-35. PMID 25633201 DOI: 10.1021/Ja510109P  1
2015 Beck T, Tetter S, Künzle M, Hilvert D. Construction of Matryoshka-type structures from supercharged protein nanocages. Angewandte Chemie (International Ed. in English). 54: 937-40. PMID 25392947 DOI: 10.1002/Anie.201408677  1
2014 Burschowsky D, Eerde Av, Ökvist M, Kienhöfer A, Kast P, Hilvert D, Krengel U. Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis. Proceedings of the National Academy of Sciences of the United States of America. 111: 17516-17521. PMID 25422475 DOI: 10.1073/Pnas.1408512111  1
2014 Metanis N, Hilvert D. Natural and synthetic selenoproteins. Current Opinion in Chemical Biology. 22: 27-34. PMID 25261915 DOI: 10.1016/J.Cbpa.2014.09.010  1
2014 Kries H, Wachtel R, Pabst A, Wanner B, Niquille D, Hilvert D. Reprogramming nonribosomal peptide synthetases for "clickable" amino acids. Angewandte Chemie (International Ed. in English). 53: 10105-8. PMID 25081643 DOI: 10.1002/Anie.201405281  1
2014 Preiswerk N, Beck T, Schulz JD, Milovník P, Mayer C, Siegel JB, Baker D, Hilvert D. Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase. Proceedings of the National Academy of Sciences of the United States of America. 111: 8013-8. PMID 24847076 DOI: 10.1073/Pnas.1401073111  1
2014 Mayer C, Müller MM, Gellman SH, Hilvert D. Building proficient enzymes with foldamer prostheses. Angewandte Chemie (International Ed. in English). 53: 6978-81. PMID 24828837 DOI: 10.1002/Anie.201400945  1
2014 Bjelic S, Kipnis Y, Wang L, Pianowski Z, Vorobiev S, Su M, Seetharaman J, Xiao R, Kornhaber G, Hunt JF, Tong L, Hilvert D, Baker D. Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. Journal of Molecular Biology. 426: 256-71. PMID 24161950 DOI: 10.1016/J.Jmb.2013.10.012  1
2014 Butz M, Kast P, Hilvert D. Affinity maturation of a computationally designed binding protein affords a functional but disordered polypeptide. Journal of Structural Biology. 185: 168-177. PMID 23537847 DOI: 10.1016/J.Jsb.2013.03.008  1
2014 Obexer R, Studer S, Giger L, Pinkas DM, Grütter MG, Baker D, Hilvert D. Active site plasticity of a computationally designed retro-aldolase enzyme Chemcatchem. 6: 1043-1050. DOI: 10.1002/Cctc.201300933  1
2013 Torbeev VY, Hilvert D. Both the cis-trans equilibrium and isomerization dynamics of a single proline amide modulate β2-microglobulin amyloid assembly. Proceedings of the National Academy of Sciences of the United States of America. 110: 20051-6. PMID 24262149 DOI: 10.1073/Pnas.1310414110  1
2013 Blomberg R, Kries H, Pinkas DM, Mittl PR, Grütter MG, Privett HK, Mayo SL, Hilvert D. Precision is essential for efficient catalysis in an evolved Kemp eliminase. Nature. 503: 418-21. PMID 24132235 DOI: 10.1038/Nature12623  1
2013 Giger L, Caner S, Obexer R, Kast P, Baker D, Ban N, Hilvert D. Evolution of a designed retro-aldolase leads to complete active site remodeling Nature Chemical Biology. 9: 494-498. PMID 23748672 DOI: 10.1038/Nchembio.1276  1
2013 Hilvert D. Design of Protein Catalysts Annual Review of Biochemistry. 82: 447-470. PMID 23746259 DOI: 10.1146/Annurev-Biochem-072611-101825  0.28
2013 Schulenburg C, Hilvert D. Protein conformational disorder and enzyme catalysis. Topics in Current Chemistry. 337: 41-67. PMID 23536241 DOI: 10.1007/128_2012_411  1
2013 Kries H, Blomberg R, Hilvert D. De novo enzymes by computational design. Current Opinion in Chemical Biology. 17: 221-228. PMID 23498973 DOI: 10.1016/J.Cbpa.2013.02.012  1
2013 Müller MM, Allison JR, Hongdilokkul N, Gaillon L, Kast P, van Gunsteren WF, Marlière P, Hilvert D. Directed evolution of a model primordial enzyme provides insights into the development of the genetic code. Plos Genetics. 9: e1003187. PMID 23300488 DOI: 10.1371/Journal.Pgen.1003187  1
2013 Müller MM, Allison JR, Hongdilokkul N, Gaillon L, Kast P, Gunsteren WFv, Marlière P, Hilvert D. Overview of amino acid substitutions at mutation hot spots for cassette mutagenesis libraries. Plos Genetics. DOI: 10.1371/Journal.Pgen.1003187.G003  1
2013 Beck T, Kuenzle M, Hilvert D. Supercharged ferritin as a cell delivery platform Acta Crystallographica Section A. 69: 331-331. DOI: 10.1107/S0108767313097134  1
2013 Mayer C, Hilvert D. A Genetically Encodable Ligand for Transfer Hydrogenation European Journal of Organic Chemistry. 2013: 3427-3431. DOI: 10.1002/Ejoc.201300340  1
2012 Stallforth P, Matthies S, Adibekian A, Gillingham DG, Hilvert D, Seeberger PH. De novo chemoenzymatic synthesis of sialic acid. Chemical Communications (Cambridge, England). 48: 11987-9. PMID 23128386 DOI: 10.1039/C2Cc37305J  1
2012 Richter F, Blomberg R, Khare SD, Kiss G, Kuzin AP, Smith AJ, Gallaher J, Pianowski Z, Helgeson RC, Grjasnow A, Xiao R, Seetharaman J, Su M, Vorobiev S, Lew S, ... ... Hilvert D, et al. Computational design of catalytic dyads and oxyanion holes for ester hydrolysis. Journal of the American Chemical Society. 134: 16197-206. PMID 22871159 DOI: 10.1021/Ja3037367  1
2012 Metanis N, Hilvert D. Strategic use of non-native diselenide bridges to steer oxidative protein folding. Angewandte Chemie (International Ed. in English). 51: 5585-8. PMID 22454335 DOI: 10.1002/Anie.201109129  1
2012 Althoff EA, Wang L, Jiang L, Giger L, Lassila JK, Wang Z, Smith M, Hari S, Kast P, Herschlag D, Hilvert D, Baker D. Robust design and optimization of retroaldol enzymes. Protein Science : a Publication of the Protein Society. 21: 717-26. PMID 22407837 DOI: 10.1002/Pro.2059  1
2012 Privett HK, Kiss G, Lee TM, Blomberg R, Chica RA, Thomas LM, Hilvert D, Houk KN, Mayo SL. Iterative approach to computational enzyme design. Proceedings of the National Academy of Sciences of the United States of America. 109: 3790-5. PMID 22357762 DOI: 10.1073/Pnas.1118082108  1
2012 Wörsdörfer B, Pianowski Z, Hilvert D. Efficient in vitro encapsulation of protein cargo by an engineered protein container. Journal of the American Chemical Society. 134: 909-11. PMID 22214519 DOI: 10.1021/Ja211011K  1
2012 Wang L, Althoff EA, Bolduc J, Jiang L, Moody J, Lassila JK, Giger L, Hilvert D, Stoddard B, Baker D. Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. Journal of Molecular Biology. 415: 615-25. PMID 22075445 DOI: 10.1016/J.Jmb.2011.10.043  1
2012 Burschowsky D, Eerde Av, Ökvist M, Kienhöfer A, Kast P, Hilvert D, Krengel U. Reaction mechanism of chorismate mutase, a model enzyme for pericyclic reactions, finally resolved Acta Crystallographica Section A. 68: 37-37. DOI: 10.1107/S0108767312099291  1
2012 Wörsdörfer B, Henning LM, Obexer R, Hilvert D. Harnessing protein symmetry for enzyme design Acs Catalysis. 2: 982-985. DOI: 10.1021/Cs300076T  1
2012 Giger L, Toscano MD, Bouzon M, Marlière P, Hilvert D. A novel genetic selection system for PLP-dependent threonine aldolases Tetrahedron. 68: 7549-7557. DOI: 10.1016/J.Tet.2012.05.097  1
2012 Stouffer A, Bengtsson LH, Sheremet M, Hilvert D. The Interplay of Catalytic Activity and Substrate Promiscuity for an Intrinsically Disordered Staphylococcal Nuclease Biophysical Journal. 102: 634a. DOI: 10.1016/J.Bpj.2011.11.3452  0.01
2012 Torbeev VY, Fumi E, Ebert MO, Schweizer WB, Hilvert D. Cis-trans peptide-bond isomerization in α-methylproline derivatives Helvetica Chimica Acta. 95: 2411-2420. DOI: 10.1002/Hlca.201200483  1
2011 Kries H, Hilvert D. Tailor-Made Peptide Synthetases Chemistry & Biology. 18: 1206-1207. PMID 22035787 DOI: 10.1016/J.Chembiol.2011.10.006  1
2011 Mayer C, Gillingham DG, Ward TR, Hilvert D. An artificial metalloenzyme for olefin metathesis Chemical Communications. 47: 12068-12070. PMID 21991583 DOI: 10.1039/C1Cc15005G  1
2011 Stafforst T, Hilvert D. Photolyase-like Repair of Psoralen-Crosslinked Nucleic Acids† Angewandte Chemie. 50: 9483-9486. PMID 21948450 DOI: 10.1002/Anie.201103611  1
2011 Butz M, Neuenschwander M, Kast P, Hilvert D. An N-terminal protein degradation tag enables robust selection of highly active enzymes. Biochemistry. 50: 8594-602. PMID 21916414 DOI: 10.1021/Bi2011338  1
2011 Wörsdörfer B, Woycechowsky KJ, Hilvert D. Directed evolution of a protein container. Science (New York, N.Y.). 331: 589-92. PMID 21292977 DOI: 10.1126/Science.1199081  1
2011 Eletsky A, Kienhofer A, Hilvert D, Pervushin K. Backbone 1H, 13C, and 15N Chemical Shift Assignments and relaxation data for Chorismate Mutase from Bacillus subtilis in complex with inhibitor Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr6495  1
2011 Siegel JB, Zanghellini A, Lovick HM, Kiss G, Lambert AR, Clair JLS, Gallaher JL, Hilvert D, Gelb MH, Stoddard BL, Houk KN, Michael FE, Baker D. A Biocatalytic Diels-Alder Reaction Using a DesignedEnzyme Synfacts. 2011: 323-323. DOI: 10.1055/S-0030-1259455  1
2011 Metanis N, Foletti C, Beld J, Hilvert D. Selenoglutathione-mediated rescue of kinetically trapped intermediates in oxidative protein folding Israel Journal of Chemistry. 51: 953-959. DOI: 10.1002/Ijch.201100105  1
2011 Stafforst T, Hilvert D. Photolyase‐artige Reparatur Psoralen‐quervernetzter Nucleinsäuren Angewandte Chemie. 123: 9655-9658. DOI: 10.1002/Ange.201103611  1
2011 Metanis N, Beld J, Hilvert D. The Chemistry of Selenocysteine Patai's Chemistry of Functional Groups. DOI: 10.1002/9780470682531.Pat0582  1
2010 Gillingham DG, Stallforth P, Adibekian A, Seeberger PH, Hilvert D. Chemoenzymatic synthesis of differentially protected 3-deoxysugars. Nature Chemistry. 2: 102-5. PMID 21124399 DOI: 10.1038/Nchem.504  1
2010 Stafforst T, Hilvert D. Modulating PNA/DNA hybridization by light. Angewandte Chemie. 49: 9998-10001. PMID 21089083 DOI: 10.1002/Anie.201004548  1
2010 Beld J, Woycechowsky KJ, Hilvert D. Diselenides as universal oxidative folding catalysts of diverse proteins. Journal of Biotechnology. 150: 481-9. PMID 20933552 DOI: 10.1016/J.Jbiotec.2010.09.956  1
2010 Jäckel C, Hilvert D. Biocatalysts by evolution. Current Opinion in Biotechnology. 21: 753-9. PMID 20850962 DOI: 10.1016/J.Copbio.2010.08.008  1
2010 Siegel JB, Zanghellini A, Lovick HM, Kiss G, Lambert AR, St Clair JL, Gallaher JL, Hilvert D, Gelb MH, Stoddard BL, Houk KN, Michael FE, Baker D. Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction. Science (New York, N.Y.). 329: 309-13. PMID 20647463 DOI: 10.1126/Science.1190239  1
2010 Jäckel C, Bloom JD, Kast P, Arnold FH, Hilvert D. Consensus protein design without phylogenetic bias. Journal of Molecular Biology. 399: 541-6. PMID 20433850 DOI: 10.1016/J.Jmb.2010.04.039  1
2010 Müller MM, Kries H, Csuhai E, Kast P, Hilvert D. Design, selection, and characterization of a split chorismate mutase. Protein Science : a Publication of the Protein Society. 19: 1000-10. PMID 20306491 DOI: 10.1002/Pro.377  1
2010 Beld J, Woycechowsky KJ, Hilvert D. Small-molecule diselenides catalyze oxidative protein folding in vivo. Acs Chemical Biology. 5: 177-82. PMID 20052969 DOI: 10.1021/Cb9002688  1
2010 Van Vleet J, Kleeb A, Kast P, Hilvert D, Cleland WW. 13C isotope effect on the reaction catalyzed by prephenate dehydratase. Biochimica Et Biophysica Acta. 1804: 752-4. PMID 19948253 DOI: 10.1016/J.Bbapap.2009.11.018  1
2010 Petrlova J, Lagerstedt J, Sriram R, Desreux J, Thonon D, Jue T, Voss J. EPR evaluation of proteins engineered to carry Gd(III) contrast labels Febs Journal. 277: 68-68. DOI: 10.1111/J.1742-4658.2010.07680.X  0.01
2010 Stafforst T, Hilvert D. Photokontrolle der PNA‐DNA‐Hybridisierung Angewandte Chemie. 122: 10195-10198. DOI: 10.1002/Ange.201004548  1
2009 Debler EW, Müller R, Hilvert D, Wilson IA. An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket. Proceedings of the National Academy of Sciences of the United States of America. 106: 18539-44. PMID 19846764 DOI: 10.1073/Pnas.0902700106  1
2009 Aldag C, Gromov IA, García-Rubio I, von Koenig K, Schlichting I, Jaun B, Hilvert D. Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine. Proceedings of the National Academy of Sciences of the United States of America. 106: 5481-6. PMID 19293375 DOI: 10.1073/Pnas.0810503106  1
2009 Stafforst T, Hilvert D. Kinetic characterization of spiropyrans in aqueous media. Chemical Communications. 287-288. PMID 19209304 DOI: 10.1039/B818050D  1
2009 Müller MM, Windsor MA, Pomerantz WC, Gellman SH, Hilvert D. A rationally designed aldolase foldamer. Angewandte Chemie (International Ed. in English). 48: 922-5. PMID 19090515 DOI: 10.1002/Anie.200804996  1
2008 Woycechowsky KJ, Choutko A, Vamvaca K, Hilvert D. Relative tolerance of an enzymatic molten globule and its thermostable counterpart to point mutation. Biochemistry. 47: 13489-96. PMID 19053245 DOI: 10.1021/Bi801108A  1
2008 Smith AJ, Müller R, Toscano MD, Kast P, Hellinga HW, Hilvert D, Houk KN. Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle. Journal of the American Chemical Society. 130: 15361-73. PMID 18939839 DOI: 10.1021/Ja803213P  1
2008 Roca M, Messer B, Hilvert D, Warshel A. On the relationship between folding and chemical landscapes in enzyme catalysis. Proceedings of the National Academy of Sciences of the United States of America. 105: 13877-82. PMID 18779576 DOI: 10.1073/Pnas.0803405105  1
2008 Fesko K, Giger L, Hilvert D. Synthesis of β-hydroxy-α-amino acids with a reengineered alanine racemase Bioorganic & Medicinal Chemistry Letters. 18: 5987-5990. PMID 18760921 DOI: 10.1016/J.Bmcl.2008.08.031  1
2008 Verdino P, Aldag C, Hilvert D, Wilson IA. Closely related antibody receptors exploit fundamentally different strategies for steroid recognition Proceedings of the National Academy of Sciences of the United States of America. 105: 11725-11730. PMID 18689687 DOI: 10.1073/Pnas.0801783105  1
2008 Vamvaca K, Jelesarov I, Hilvert D. Kinetics and thermodynamics of ligand binding to a molten globular enzyme and its native counterpart. Journal of Molecular Biology. 382: 971-977. PMID 18680748 DOI: 10.1016/J.Jmb.2008.07.049  1
2008 Jäckel C, Kast P, Hilvert D. Protein design by directed evolution. Annual Review of Biophysics. 37: 153-73. PMID 18573077 DOI: 10.1146/Annurev.Biophys.37.032807.125832  1
2008 Beld J, Woycechowsky KJ, Hilvert D. Catalysis of oxidative protein folding by small-molecule diselenides. Biochemistry. 47: 6985-7. PMID 18553979 DOI: 10.1021/Bi8008906  1
2008 Casi G, Roelfes G, Hilvert D. Selenoglutaredoxin as a glutathione peroxidase mimic. Chembiochem : a European Journal of Chemical Biology. 9: 1623-31. PMID 18548475 DOI: 10.1002/Cbic.200700745  0.08
2008 Serafimov JM, Gillingham D, Kuster S, Hilvert D. The putative Diels-Alderase macrophomate synthase is an efficient aldolase. Journal of the American Chemical Society. 130: 7798-9. PMID 18512926 DOI: 10.1021/Ja8017994  0.04
2008 Debler EW, Müller R, Hilvert D, Wilson IA. Conformational isomerism can limit antibody catalysis. The Journal of Biological Chemistry. 283: 16554-60. PMID 18417480 DOI: 10.1074/Jbc.M710256200  1
2008 Jiang L, Althoff EA, Clemente FR, Doyle L, Röthlisberger D, Zanghellini A, Gallaher JL, Betker JL, Tanaka F, Barbas CF, Hilvert D, Houk KN, Stoddard BL, Baker D. De novo computational design of retro-aldol enzymes. Science (New York, N.Y.). 319: 1387-91. PMID 18323453 DOI: 10.1126/Science.1152692  1
2008 Piatesi A, Aldag C, Hilvert D. Switching antibody specificity through minimal mutation. Journal of Molecular Biology. 377: 993-1001. PMID 18295792 DOI: 10.1016/J.Jmb.2008.01.069  1
2007 Pervushin K, Vamvaca K, Vögeli B, Hilvert D. Structure and dynamics of a molten globular enzyme. Nature Structural & Molecular Biology. 14: 1202-1206. PMID 17994104 DOI: 10.1038/Nsmb1325  1
2007 Neuenschwander M, Butz M, Heintz C, Kast P, Hilvert D. A simple selection strategy for evolving highly efficient enzymes. Nature Biotechnology. 25: 1145-7. PMID 17873865 DOI: 10.1038/Nbt1341  1
2007 Casi G, Hilvert D. Reinvestigation of a selenopeptide with purportedly high glutathione peroxidase activity. Journal of Biological Chemistry. 282: 30518-30522. PMID 17724019 DOI: 10.1074/Jbc.M705528200  1
2007 Kleeb AC, Edalat MH, Gamper M, Haugstetter J, Giger L, Neuenschwander M, Kast P, Hilvert D. Metabolic engineering of a genetic selection system with tunable stringency. Proceedings of the National Academy of Sciences of the United States of America. 104: 13907-12. PMID 17715291 DOI: 10.1073/Pnas.0705379104  1
2007 Serafimov JM, Westfeld T, Meier BH, Hilvert D. Trapping and structural elucidation of an intermediate in the macrophomate synthase reaction pathway. Journal of the American Chemical Society. 129: 9580-1. PMID 17636922 DOI: 10.1021/Ja073087Y  1
2007 Toscano MD, Müller MM, Hilvert D. Enhancing activity and controlling stereoselectivity in a designed PLP-dependent aldolase. Angewandte Chemie (International Ed. in English). 46: 4468-70. PMID 17486616 DOI: 10.1002/Anie.200700710  1
2007 Serafimov JM, Lehmann HC, Oikawa H, Hilvert D. Active site mutagenesis of the putative Diels-Alderase macrophomate synthase. Chemical Communications (Cambridge, England). 1701-3. PMID 17457413 DOI: 10.1039/B703177G  1
2007 Toscano MD, Woycechowsky KJ, Hilvert D. Minimalist active-site redesign: teaching old enzymes new tricks. Angewandte Chemie (International Ed. in English). 46: 3212-36. PMID 17450624 DOI: 10.1002/Anie.200604205  1
2007 Beld J, Woycechowsky KJ, Hilvert D. Selenoglutathione: efficient oxidative protein folding by a diselenide. Biochemistry. 46: 5382-90. PMID 17419591 DOI: 10.1021/Bi700124P  1
2007 Aemissegger A, Hilvert D. Synthesis and application of an azobenzene amino acid as a light-switchable turn element in polypeptides. Nature Protocols. 2: 161-167. PMID 17401350 DOI: 10.1038/Nprot.2006.488  1
2007 Müller R, Debler EW, Steinmann M, Seebeck FP, Wilson IA, Hilvert D. Bifunctional catalysis of proton transfer at an antibody active site. Journal of the American Chemical Society. 129: 460-1. PMID 17226987 DOI: 10.1021/Ja066578B  1
2007 Woycechowsky KJ, Vamvaca K, Hilvert D. Novel enzymes through design and evolution. Advances in Enzymology and Related Areas of Molecular Biology. 75: 241-94, xiii. PMID 17124869 DOI: 10.1002/9780471224464.Ch4  1
2007 Flögel O, Casi G, Hilvert D, Seebach D. Preparation of the β3-homoselenocysteine derivatives Fmoc-β3hSec(PMB)-OH and Boc-β3hSec(PMB)-OH for solution and solid-phase-peptide synthesis and selenoligation Helvetica Chimica Acta. 90: 1651-1666. DOI: 10.1002/Hlca.200790171  1
2007 Toscano M, Woycechowsky K, Hilvert D. Minimale Umgestaltung aktiver Enzymtaschen – wie man alten Enzymen neue Kunststücke beibringt Angewandte Chemie. 119: 3274-3300. DOI: 10.1002/Ange.200604205  0.04
2006 Kleeb AC, Kast P, Hilvert D. A monofunctional and thermostable prephenate dehydratase from the archaeon Methanocaldococcus jannaschii. Biochemistry. 45: 14101-14110. PMID 17115705 DOI: 10.1021/Bi061274N  1
2006 Besenmatter W, Kast P, Hilvert D. Relative tolerance of mesostable and thermostable protein homologs to extensive mutation Proteins. 66: 500-506. PMID 17096428 DOI: 10.1002/Prot.21227  1
2006 Seebeck FP, Guainazzi A, Amoreira C, Baldridge KK, Hilvert D. Stereoselectivity and expanded substrate scope of an engineered PLP-dependent aldolase. Angewandte Chemie (International Ed. in English). 45: 6824-6. PMID 17001724 DOI: 10.1002/Anie.200602529  1
2006 Jurt S, Aemissegger A, Güntert P, Zerbe O, Hilvert D. A Photoswitchable Miniprotein Based on the Sequence of Avian Pancreatic Polypeptide Angewandte Chemie. 45: 6297-6300. PMID 16933352 DOI: 10.1002/Anie.200602084  1
2006 Kikuchi K, Hannak RB, Guo MJ, Kirby AJ, Hilvert D. Toward bifunctional antibody catalysis. Bioorganic & Medicinal Chemistry. 14: 6189-96. PMID 16782349 DOI: 10.1016/J.Bmc.2006.05.071  1
2006 Woycechowsky KJ, Seebeck FP, Hilvert D. Tunnel plasticity and quaternary structural integrity of a pentameric protein ring. Protein Science : a Publication of the Protein Society. 15: 1106-14. PMID 16641488 DOI: 10.1110/Ps.052044606  1
2006 Seebeck FP, Woycechowsky KJ, Zhuang W, Rabe JP, Hilvert D. A simple tagging system for protein encapsulation. Journal of the American Chemical Society. 128: 4516-7. PMID 16594656 DOI: 10.1021/Ja058363S  1
2006 DeClue MS, Baldridge KK, Kast P, Hilvert D. Experimental and computational investigation of the uncatalyzed rearrangement and elimination reactions of isochorismate. Journal of the American Chemical Society. 128: 2043-51. PMID 16464106 DOI: 10.1021/Ja056714X  1
2006 Verdino P, Aldag C, Hilvert D, Wilson IA. Antibodies: specificity and promiscuity of ligand recognition Acta Crystallographica Section a Foundations of Crystallography. 62: s38-s38. DOI: 10.1107/S0108767306099247  0.04
2005 DeClue MS, Baldridge KK, Künzler DE, Kast P, Hilvert D. Isochorismate pyruvate lyase: a pericyclic reaction mechanism? Journal of the American Chemical Society. 127: 15002-3. PMID 16248620 DOI: 10.1021/Ja055871T  1
2005 Wright SK, DeClue MS, Mandal A, Lee L, Wiest O, Cleland WW, Hilvert D. Isotope effects on the enzymatic and nonenzymatic reactions of chorismate. Journal of the American Chemical Society. 127: 12957-64. PMID 16159290 DOI: 10.1021/Ja052929V  1
2005 Walter KU, Vamvaca K, Hilvert D. An active enzyme constructed from a 9-amino acid alphabet. The Journal of Biological Chemistry. 280: 37742-6. PMID 16144843 DOI: 10.1074/Jbc.M507210200  1
2005 Künzler DE, Sasso S, Gamper M, Hilvert D, Kast P. Mechanistic insights into the isochorismate pyruvate lyase activity of the catalytically promiscuous PchB from combinatorial mutagenesis and selection. The Journal of Biological Chemistry. 280: 32827-34. PMID 16036918 DOI: 10.1074/Jbc.M506883200  1
2005 Vamvaca K, Butz M, Walter KU, Taylor SV, Hilvert D. Simultaneous optimization of enzyme activity and quaternary structure by directed evolution. Protein Science : a Publication of the Protein Society. 14: 2103-14. PMID 15987889 DOI: 10.1110/Ps.051431605  1
2005 Eletsky A, Kienhöfer A, Hilvert D, Pervushin K. Investigation of ligand binding and protein dynamics in Bacillus subtilis chorismate mutase by transverse relaxation optimized spectroscopy-nuclear magnetic resonance. Biochemistry. 44: 6788-6799. PMID 15865424 DOI: 10.1021/Bi0474259  1
2005 Kräutler V, Aemissegger A, Hünenberger PH, Hilvert D, Hansson T, van Gunsteren WF. Use of molecular dynamics in the design and structure determination of a photoinducible beta-hairpin. Journal of the American Chemical Society. 127: 4935-42. PMID 15796559 DOI: 10.1021/Ja044253U  0.01
2005 Debler EW, Ito S, Seebeck FP, Heine A, Hilvert D, Wilson IA. Structural origins of efficient proton abstraction from carbon by a catalytic antibody. Proceedings of the National Academy of Sciences of the United States of America. 102: 4984-9. PMID 15788533 DOI: 10.1073/Pnas.0409207102  1
2005 Aemissegger A, Kräutler V, van Gunsteren WF, Hilvert D. A photoinducible beta-hairpin. Journal of the American Chemical Society. 127: 2929-36. PMID 15740129 DOI: 10.1021/Ja0442567  1
2005 Seebeck FP, Hilvert D. Positional ordering of reacting groups contributes significantly to the efficiency of proton transfer at an antibody active site. Journal of the American Chemical Society. 127: 1307-1312. PMID 15669871 DOI: 10.1021/Ja044647L  1
2005 Sasso S, Ramakrishnan C, Gamper M, Hilvert D, Kast P. Characterization of the secreted chorismate mutase from the pathogen Mycobacterium tuberculosis. The Febs Journal. 272: 375-89. PMID 15654876 DOI: 10.1111/J.1742-4658.2004.04478.X  1
2004 Vamvaca K, Vögeli B, Kast P, Pervushin K, Hilvert D. An enzymatic molten globule: efficient coupling of folding and catalysis. Proceedings of the National Academy of Sciences of the United States of America. 101: 12860-12864. PMID 15322276 DOI: 10.1073/Pnas.0404109101  1
2004 Besenmatter W, Kast P, Hilvert D. New enzymes from combinatorial library modules. Methods in Enzymology. 388: 91-102. PMID 15289064 DOI: 10.1016/S0076-6879(04)88009-1  1
2004 Hu Y, Houk KN, Kikuchi K, Hotta K, Hilvert D. Nonspecific medium effects versus specific group positioning in the antibody and albumin catalysis of the base-promoted ring-opening reactions of benzisoxazoles. Journal of the American Chemical Society. 126: 8197-205. PMID 15225061 DOI: 10.1021/Ja0490727  1
2004 Piatesi A, Hilvert D. Immunological optimization of a generic hydrophobic pocket for high affinity hapten binding and Diels-Alder activity. Chembiochem. 5: 460-466. PMID 15185369 DOI: 10.1002/Cbic.200300806  1
2004 Woycechowsky KJ, Hilvert D. Deciphering enzymes. Genetic selection as a probe of structure and mechanism. European Journal of Biochemistry / Febs. 271: 1630-7. PMID 15096202 DOI: 10.1111/J.1432-1033.2004.04073.X  1
2004 Roelfes G, Hilvert D. Incorporation of selenomethionine into proteins through selenohomocysteine-mediated ligation. Angewandte Chemie (International Ed. in English). 42: 2275-7. PMID 12772161 DOI: 10.1002/Anie.200250830  0.16
2003 Wendt S, McCombie G, Daniel J, Kienhöfer A, Hilvert D, Zenobi R. Quantitative evaluation of noncovalent chorismate mutase-inhibitor binding by ESI-MS. Journal of the American Society For Mass Spectrometry. 14: 1470-1476. PMID 14652193 DOI: 10.1016/J.Jasms.2003.08.003  1
2003 Casi G, Hilvert D. Convergent protein synthesis. Current Opinion in Structural Biology. 13: 589-594. PMID 14568613 DOI: 10.1016/J.Sbi.2003.09.008  1
2003 Seebeck FP, Hilvert D. Conversion of a PLP-dependent racemase into an aldolase by a single active site mutation. Journal of the American Chemical Society. 125: 10158-10159. PMID 12926923 DOI: 10.1021/Ja036707D  1
2003 Mandal A, Hilvert D. Charge Optimization Increases the Potency and Selectivity of a Chorismate Mutase Inhibitor Journal of the American Chemical Society. 125: 5598-5599. PMID 12733875 DOI: 10.1021/Ja029447T  1
2003 Kienhöfer A, Kast P, Hilvert D. Selective stabilization of the chorismate mutase transition state by a positively charged hydrogen bond donor. Journal of the American Chemical Society. 125: 3206-3207. PMID 12630863 DOI: 10.1021/Ja0341992  1
2003 Ujaque G, Tantillo DJ, Hu Y, Houk KN, Hotta K, Hilvert D. Catalysis on the coastline: theozyme, molecular dynamics, and free energy perturbation analysis of antibody 21D8 catalysis of the decarboxylation of 5-nitro-3-carboxybenzisoxazole. Journal of Computational Chemistry. 24: 98-110. PMID 12483679 DOI: 10.1002/Jcc.10151  1
2003 Backes AC, Hotta K, Hilvert D. Promiscuity in Antibody Catalysis: Esterolytic Activity of the Decarboxylase 21D8 Helvetica Chimica Acta. 86: 1167-1174. DOI: 10.1002/Hlca.200390101  1
2002 Quaderer R, Hilvert D. Selenocysteine-mediated backbone cyclization of unprotected peptides followed by alkylation, oxidative elimination or reduction of the selenol. Chemical Communications. 2620-2621. PMID 12510266 DOI: 10.1039/B208288H  1
2002 Eletsky A, Heinz T, Moreira O, Kienhöfer A, Hilvert D, Pervushin K. Direct NMR observation and DFT calculations of a hydrogen bond at the active site of a 44 kDa enzyme. Journal of Biomolecular Nmr. 24: 31-39. PMID 12449416 DOI: 10.1023/A:1020697627485  1
2002 Hannak RB, Konrat R, Schüler W, Kräutler B, Auditor MM, Hilvert D. An Antibody that Reconstitutes the “Base‐On” Form of B12 Coenzymes Angewandte Chemie. 41: 3613-3616. PMID 12370907 DOI: 10.1002/1521-3773(20021004)41:19<3613::Aid-Anie3613>3.0.Co;2-X  1
2002 Aemissegger A, Jaun B, Hilvert D. Investigation of the enzymatic and nonenzymatic cope rearrangement of carbaprephenate to carbachorismate. Journal of Organic Chemistry. 67: 6725-6730. PMID 12227803 DOI: 10.1021/Jo026096S  1
2002 Chen J, Deng Q, Wang R, Houk K, Hilvert D. Shape complementarity, binding-site dynamics, and transition state stabilization: a theoretical study of Diels-Alder catalysis by antibody 1E9. Chembiochem : a European Journal of Chemical Biology. 1: 255-61. PMID 11828417 DOI: 10.1002/1439-7633(20001117)1:4<255::Aid-Cbic255>3.0.Co;2-S  0.04
2002 Hotta K, Wilson IA, Hilvert D. Probing ligand recognition in the decarboxylase antibody 21D8: implications for the catalytic mechanism. Biochemistry. 41: 772-9. PMID 11790098 DOI: 10.1021/Bi0158167  1
2002 Piatesi A, Hilvert D. Optimized production of the Diels-Alderase antibody 1E9 as a chimeric Fab Canadian Journal of Chemistry. 80: 657-664. DOI: 10.1139/V02-057  1
2002 Gozin Y, Hilvert D. Steric and Electronic Effects on an Antibody‐Catalyzed Diels–Alder Reaction Helvetica Chimica Acta. 85: 4328-4336. DOI: 10.1002/Hlca.200290015  1
2002 Hannak RB, Konrat R, Schüler W, Kräutler B, Auditor MM, Hilvert D. Ein Antikörper, der die “Base‐on”‐Form von B12‐Coenzymen rekonstituiert Angewandte Chemie. 114: 3765-3768. DOI: 10.1002/1521-3757(20021004)114:19<3765::Aid-Ange3765>3.0.Co;2-N  1
2001 Sewing A, Hilvert D. Fmoc‐Compatible Solid‐Phase Peptide Synthesis of Long C‐Terminal Peptide Thioesters Angewandte Chemie. 40: 3395-3396. PMID 11592149 DOI: 10.1002/1521-3773(20010917)40:18<3395::Aid-Anie3395>3.0.Co;2-G  1
2001 Taylor SV, Kast P, Hilvert D. Investigating and Engineering Enzymes by Genetic Selection. Angewandte Chemie. 40: 3310-3335. PMID 11592132 DOI: 10.1002/1521-3773(20010917)40:18<3310::Aid-Anie3310>3.0.Co;2-P  1
2001 Quaderer R, Hilvert D. Improved Synthesis of C-Terminal Peptide Thioesters on “Safety-Catch” Resins Using LiBr/THF Organic Letters. 3: 3181-3184. PMID 11574025 DOI: 10.1021/Ol016492H  1
2001 Taylor SV, Walter KU, Kast P, Hilvert D. Searching sequence space for protein catalysts. Proceedings of the National Academy of Sciences of the United States of America. 98: 10596-601. PMID 11535813 DOI: 10.1073/Pnas.191159298  1
2001 Sewing A, Hilvert D. Fmoc‐kompatible Festphasensynthese von langen, C‐terminalen Peptidthioestern Angewandte Chemie. 113: 3503-3505. DOI: 10.1002/1521-3757(20010917)113:18<3503::Aid-Ange3503>3.0.Co;2-U  1
2001 Taylor SV, Kast P, Hilvert D. Genetische Selektion – eine Strategie zur Untersuchung und Herstellung von Enzymen Angewandte Chemie. 113: 3408-3436. DOI: 10.1002/1521-3757(20010917)113:18<3408::Aid-Ange3408>3.0.Co;2-6  1
2000 Hotta K, Lange H, Tantillo DJ, Houk KN, Hilvert D, Wilson IA. Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8. Journal of Molecular Biology. 302: 1213-25. PMID 11183784 DOI: 10.1006/Jmbi.2000.4503  1
2000 Hilvert D. Critical Analysis of Antibody Catalysis Annual Review of Biochemistry. 69: 751-793. PMID 10966475 DOI: 10.1146/Annurev.Biochem.69.1.751  0.12
2000 Kast P, Grisostomi C, Chen IA, Li S, Krengel U, Xue Y, Hilvert D. A strategically positioned cation is crucial for efficient catalysis by chorismate mutase. The Journal of Biological Chemistry. 275: 36832-8. PMID 10960481 DOI: 10.1074/Jbc.M006351200  1
2000 Swinnen D, Hilvert D. Facile, Fmoc-Compatible Solid-Phase Synthesis of Peptide C-Terminal Thioesters Organic Letters. 2: 2439-2442. PMID 10956516 DOI: 10.1021/Ol0060836  0.08
2000 Voordijk S, Hansson T, Hilvert D, van Gunsteren WF. Molecular dynamics simulations highlight mobile regions in proteins: A novel suggestion for converting a murine V(H) domain into a more tractable species. Journal of Molecular Biology. 300: 963-73. PMID 10891281 DOI: 10.1006/Jmbi.2000.3890  0.01
2000 Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA. Evolution of shape complementarity and catalytic efficiency from a primordial antibody template. Science (New York, N.Y.). 286: 2345-8. PMID 10600746 DOI: 10.1126/Science.286.5448.2345  0.12
2000 Hollfelder F, Kirby AJ, Tawfik DS, Kikuchi K, Hilvert D. Characterization of proton-transfer catalysis by serum albumins Journal of the American Chemical Society. 122: 1022-1029. DOI: 10.1021/Ja993471Y  1
2000 Hotta K, Kikuchi K, Hilvert D. Catalysis of 3‐Carboxy‐1,2‐benzisoxazole Decarboxylation by Hydrophobic Antibody Binding Pockets Helvetica Chimica Acta. 83: 2183-2191. DOI: 10.1002/1522-2675(20000906)83:9<2183::Aid-Hlca2183>3.0.Co;2-C  1
1999 Zhou ZS, Flohr A, Hilvert D. An Antibody-Catalyzed Allylic Sulfoxide-Sulfenate Rearrangement. The Journal of Organic Chemistry. 64: 8334-8341. PMID 11674756 DOI: 10.1021/Jo991299A  1
1999 Gustin DJ, Hilvert D. Chemoenzymatic Synthesis of Isotopically Labeled Chorismic Acids. Journal of Organic Chemistry. 64: 4935-4938. PMID 11674574 DOI: 10.1021/Jo9823792  0.12
1999 Dinakarpandian D, Shenoy BC, Hilvert D, McRee DE, McTigue M, Carey PR. Electric fields in active sites: Substrate switching from null to strong fields in thiol- and selenol-subtilisins Biochemistry. 38: 6659-6667. PMID 10350485 DOI: 10.1021/Bi9902541  1
1999 Mattei P, Kast P, Hilvert D. Bacillus subtilis chorismate mutase is partially diffusion-controlled. Febs Journal. 261: 25-32. PMID 10103029 DOI: 10.1046/J.1432-1327.1999.00169.X  1
1999 Gustin DJ, Mattei P, Kast P, Wiest O, Lee L, Cleland WW, Hilvert D. Heavy Atom Isotope Effects Reveal a Highly Polarized Transition State for Chorismate Mutase Journal of the American Chemical Society. 121: 1756-1757. DOI: 10.1021/Ja9841759  0.01
1998 MacBeath G, Kast P, Hilvert D. Probing enzyme quaternary structure by combinatorial mutagenesis and selection. Protein Science : a Publication of the Protein Society. 7: 1757-67. PMID 10082372 DOI: 10.1002/Pro.5560070810  1
1998 MacBeath G, Kast P, Hilvert D. A small, thermostable, and monofunctional chorismate mutase from the archaeon Methanococcus jannaschii. Biochemistry. 37: 10062-73. PMID 9665711 DOI: 10.1021/Bi980449T  1
1998 MacBeath G, Kast P, Hilvert D. Exploring sequence constraints on an interhelical turn using in vivo selection for catalytic activity. Protein Science : a Publication of the Protein Society. 7: 325-35. PMID 9521108 DOI: 10.1002/Pro.5560070212  1
1998 MacBeath G, Kast P, Hilvert D. Redesigning enzyme topology by directed evolution. Science (New York, N.Y.). 279: 1958-61. PMID 9506949 DOI: 10.1126/Science.279.5358.1958  1
1997 Kast P, Hilvert D. 3D structural information as a guide to protein engineering using genetic selection. Current Opinion in Structural Biology. 7: 470-479. PMID 9266167 DOI: 10.1016/S0959-440X(97)80109-1  1
1997 Kast P, Tewari YB, Wiest O, Hilvert D, Houk KN, Goldberg RN. Thermodynamics of the Conversion of Chorismate to Prephenate:  Experimental Results and Theoretical Predictions The Journal of Physical Chemistry B. 101: 10976-10982. DOI: 10.1021/Jp972501L  0.01
1997 Zhou ZS, Jiang N, Hilvert D. An Antibody-Catalyzed Selenoxide Elimination Journal of the American Chemical Society. 119: 3623-3624. DOI: 10.1021/Ja963748J  1
1997 Peterson EB, Hilvert D. Selenosubtilisin's peroxidase activity does not require an intact oxyanion hole Tetrahedron. 53: 12311-12317. DOI: 10.1016/S0040-4020(97)00562-0  1
1997 Grisostomi C, Kast P, Pulido R, Huynh J, Hilvert D. Efficient in vivo synthesis and rapid purification of chorismic acid using an engineered Escherichia coil strain Bioorganic Chemistry. 25: 297-305. DOI: 10.1006/Bioo.1997.1073  1
1996 Hilvert D. Bioorganic chemistry: A chemical approach to enzyme action: by Herman Dugas. Third edition, Springer-Verlag, New York, 1996, 700 pp. $49.95 (Hardcover) ISBN 0-387-94494-X Chemistry & Biology. 3: 727. PMID 8939687 DOI: 10.1016/S1074-5521(96)90247-1  0.08
1996 MacBeath G, Hilvert D. Hydrolytic antibodies: variations on a theme. Chemistry & Biology. 3: 433-45. PMID 8807874 DOI: 10.1016/S1074-5521(96)90091-5  1
1996 Tang Y, Jiang N, Parakh C, Hilvert D. Selection of linkers for a catalytic single-chain antibody using phage display technology. Journal of Biological Chemistry. 271: 15682-15686. PMID 8663068 DOI: 10.1074/Jbc.271.26.15682  1
1996 Kast P, Asif-Ullah M, Jiang N, Hilvert D. Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection: the importance of electrostatic catalysis Proceedings of the National Academy of Sciences of the United States of America. 93: 5043-5048. PMID 8643526 DOI: 10.1073/Pnas.93.10.5043  1
1996 Kast P, Hilvert D. Genetic selection strategies for generating and characterizing catalysts Pure and Applied Chemistry. 68: 2017-2024. DOI: 10.1351/Pac199668112017  1
1996 Kikuchi K, Thorn SN, Hilvert D. Albumin-Catalyzed Proton Transfer Journal of the American Chemical Society. 118: 8184-8185. DOI: 10.1021/Ja9617395  1
1996 Kast P, Hartgerink JD, Asif-Ullah M, Hilvert D. Electrostatic catalysis of the claisen rearrangement: Probing the role of Glu78 in Bacillus subtilis chorismate mutase by genetic selection Journal of the American Chemical Society. 118: 3069-3070. DOI: 10.1021/Ja953701I  1
1996 Na J, Houk KN, Hilvert D. Transition state of the base-promoted ring-opening of isoxazoles. Theoretical prediction of catalytic functionalities and design of haptens for antibody production Journal of the American Chemical Society. 118: 6462-6471. DOI: 10.1021/Ja953550J  1
1996 O'Connor MJ, Dunlap RB, Odom JD, Hilvert D, Pusztai-Carey M, Shenoy BC, Carey PR. Probing an acyl enzyme of selenosubtilisin by raman spectroscopy Journal of the American Chemical Society. 118: 239-240. DOI: 10.1021/Ja952981Z  1
1996 Kast P, Asif-Ullah M, Hilvert D. Is chorismate mutase a prototypic entropy trap? - Activation parameters for the Bacillus subtilis enzyme Tetrahedron Letters. 37: 2691-2694. DOI: 10.1016/0040-4039(96)00338-3  1
1996 Haynes MR, Lenz M, Taussig MJ, Wilson IA, Hilvert D. Sequence Similarity and Cross-Reactivity of a Diels-Alder Catalyst and an Anti-Progesterone Antibody Israel Journal of Chemistry. 36: 151-159. DOI: 10.1002/Ijch.199600021  0.01
1995 Thorn SN, Daniels RG, Auditor MM, Hilvert D. Large rate accelerations in antibody catalysis by strategic use of haptenic charge Nature. 373: 228-230. PMID 7816136 DOI: 10.1038/373228A0  1
1995 Peterson EB, Hilvert D. Nonessential active site residues modulate selenosubtilisin's kinetic mechanism. Biochemistry. 34: 6616-20. PMID 7756293 DOI: 10.1021/Bi00020A006  1
1994 Hilvert D. Chemical synthesis of proteins Chemistry & Biology. 1: 201-203. PMID 9383391 DOI: 10.1016/1074-5521(94)90011-6  0.32
1994 Haynes MR, Stura EA, Hilvert D, Wilson IA. Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart. Science (New York, N.Y.). 263: 646-52. PMID 8303271 DOI: 10.1126/Science.8303271  1
1994 Haynes MR, Stura EA, Hilvert D, Wilson IA. Crystallization and preliminary structural studies of a chorismate mutase catalytic antibody complexed with a transition state analog. Proteins. 18: 198-200. PMID 8159668 DOI: 10.1002/Prot.340180211  1
1994 Morris KN, Tarasow TM, Julin CM, Simons SL, Hilvert D, Gold L. Enrichment for RNA molecules that bind a Diels-Alder transition state analog Proceedings of the National Academy of Sciences of the United States of America. 91: 13028-13032. PMID 7528930 DOI: 10.1073/Pnas.91.26.13028  1
1994 Tarasow TM, Lewis C, Hilvert D. Investigation of Medium Effects in a Family of Decarboxylase Antibodies Journal of the American Chemical Society. 116: 7959-7963. DOI: 10.1021/Ja00097A001  1
1994 MacBeath G, Hilvert D. Monitoring Catalytic Activity by Immunoassay: Implications for Screening Journal of the American Chemical Society. 116: 6101-6106. DOI: 10.1021/Ja00093A006  1
1994 Shin JA, Hilvert D. Mechanistic studies of an antibody with chorismate mutase activity Bioorganic & Medicinal Chemistry Letters. 4: 2945-2948. DOI: 10.1016/S0960-894X(01)80845-3  0.01
1993 Syed R, Wu ZP, Hogle JM, Hilvert D. Crystal structure of selenosubtilisin at 2.0-A resolution. Biochemistry. 32: 6157-64. PMID 8512925 DOI: 10.1021/Bi00075A007  1
1993 Bell IM, Fisher ML, Wu ZP, Hilvert D. Kinetic studies on the peroxidase activity of selenosubtilisin. Biochemistry. 32: 3754-62. PMID 8385489 DOI: 10.1021/Bi00065A030  1
1993 Campbell AP, Tarasow TM, Massefski W, Wright PE, Hilvert D. Binding of a high-energy substrate conformer in antibody catalysis. Proceedings of the National Academy of Sciences of the United States of America. 90: 8663-7. PMID 8378345 DOI: 10.1073/Pnas.90.18.8663  0.01
1993 Bell IM, Hilvert D. Peroxide dependence of the semisynthetic enzyme selenosubtilisin. Biochemistry. 32: 13969-13973. PMID 8268174 DOI: 10.1021/Bi00213A029  1
1993 Grate JW, McGill RA, Hilvert D. Analysis of solvent effects on the decarboxylation of benzisoxazole-3-carboxylate ions using linear solvation energy relationships : relevance to catalysis in an antibody binding site Journal of the American Chemical Society. 115: 8577-8584. DOI: 10.1021/Ja00072A009  1
1993 Lewis C, Paneth P, O'Leary MH, Hilvert D. Carbon kinetic isotope effects on the spontaneous and antibody-catalyzed decarboxylation of 5-nitro-3-carboxybenzisoxazole Journal of the American Chemical Society. 115: 1410-1413. DOI: 10.1021/Ja00057A025  1
1993 Bell IM, Fisher ML, Wu ZP, Hilvert D. Kinetic studies on the peroxidase activity of selenosubtilisin. [Erratum to document cited in CA119(1):3765q] Biochemistry. 32: 8980-8980. DOI: 10.1021/Bi00085A032  1
1993 Hilvert D. Antibody catalysis of carbon-carbon bond formation and cleavage Accounts of Chemical Research. 26: 552-558. DOI: 10.1021/Ar00034A006  1
1992 House KL, Dunlap RB, Odom JD, Wu ZP, Hilvert D. Structural characterization of selenosubtilisin by selenium-77 NMR spectroscopy Journal of the American Chemical Society. 114: 8573-8579. DOI: 10.1021/Ja00048A033  1
1991 Tang Y, Hicks JB, Hilvert D. In vivo catalysis of a metabolically essential reaction by an antibody. Proceedings of the National Academy of Sciences of the United States of America. 88: 8784-8786. PMID 1924339 DOI: 10.1073/Pnas.88.19.8784  1
1991 Hilvert D, Hill KW. Antibody catalysis of concerted, carbon-carbon bond-forming reactions. Methods in Enzymology. 203: 352-369. PMID 1762564 DOI: 10.1016/0076-6879(91)03020-H  1
1990 Wu ZP, Hilvert D. Selenosubtilisin as a glutathione peroxidase mimic Journal of the American Chemical Society. 112: 5647-5648. DOI: 10.1021/Ja00170A043  1
1989 Hilvert D, Hill KW, Nared KD, Auditor MTM. Antibody catalysis of the Diels-Alder reaction Journal of the American Chemical Society. 111: 9261-9262. DOI: 10.1021/Ja00208A037  1
1989 Wu ZP, Hilvert D. Conversion of a protease into an acyl transferase: selenolsubtilisin Journal of the American Chemical Society. 111: 4513-4514. DOI: 10.1021/Ja00194A064  1
1988 Hilvert D, Nared KD. Stereospecific Claisen rearrangement catalyzed by an antibody Journal of the American Chemical Society. 110: 5593-5594. DOI: 10.1021/Ja00224A066  1
1988 Hilvert D, Hatanaka Y, Kaiser ET. A highly active thermophilic semisynthetic flavoenzyme Journal of the American Chemical Society. 110: 682-689. DOI: 10.1021/Ja00211A004  1
1986 Hilvert D, Gardell SJ, Rutter WJ, Kaiser ET. Evidence against a crucial role for the phenolic hydroxyl of Tyr-248 in peptide and ester hydrolyses catalyzed by carboxypeptidase A: Comparative studies of the pH dependencies of the native and Phe-248-mutant forms Journal of the American Chemical Society. 108: 5298-5304. DOI: 10.1002/Chin.198652064  1
1985 Hilvert D, Kaiser ET. New semisynthetic flavoenzymes based on a tetrameric protein template, glyceraldehyde-3-phosphate dehydrogenase Journal of the American Chemical Society. 107: 5805-5806. DOI: 10.1021/Ja00306A040  1
1983 Breslow R, Chin J, Hilvert D, Trainor G. Evidence for the general base mechanism in carboxypeptidase A-catalyzed reactions: partitioning studies on nucleophiles and H2(18)O kinetic isotope effects Proceedings of the National Academy of Sciences of the United States of America. 80: 4585-4589. PMID 6576353 DOI: 10.1073/Pnas.80.14.4585  0.16
1981 Hilvert DM, Jacobs MD, Morton TH. An efficient preparation of tetramethylallene Organic Preparations and Procedures International. 13: 197-201. DOI: 10.1080/00304948109356126  1
Show low-probability matches.