JoAnne Stubbe - Publications

Affiliations: 
Chemistry Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
biological chemistry
Website:
http://www.mit.edu/~chemistry/faculty/stubbe.html

234 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Meyer A, Kehl A, Cui C, Reichardt FAK, Hecker F, Funk LM, Ghosh MK, Pan KT, Urlaub H, Tittmann K, Stubbe J, Bennati M. F Electron-Nuclear Double Resonance Reveals Interaction between Redox-Active Tyrosines across the α/β Interface of Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 35652913 DOI: 10.1021/jacs.2c02906  0.789
2021 Stubbe J, Nocera DG. Radicals in Biology: Your Life Is in Their Hands. Journal of the American Chemical Society. 143: 13463-13472. PMID 34423635 DOI: 10.1021/jacs.1c05952  0.46
2020 Cui C, Greene BL, Kang G, Drennan CL, Stubbe J, Nocera DG. Gated Proton Release during Radical Transfer at the Subunit Interface of Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 33353307 DOI: 10.1021/jacs.0c07879  0.723
2020 Reinhardt CR, Li P, Kang G, Stubbe J, Drennan CL, Hammes-Schiffer S. Conformational Motions and Water Networks at the α/β Interface in E. coli Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 32631052 DOI: 10.1021/Jacs.0C04325  0.345
2020 Greene BL, Kang G, Cui C, Bennati M, Nocera DG, Drennan CL, Stubbe J. Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets. Annual Review of Biochemistry. 89: 45-75. PMID 32569524 DOI: 10.1146/Annurev-Biochem-013118-111843  0.722
2020 Kang G, Taguchi AT, Stubbe J, Drennan CL. Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex. Science (New York, N.Y.). PMID 32217749 DOI: 10.1126/Science.Aba6794  0.402
2020 Ravichandran KR, Olshansky L, Nocera DG, Stubbe J. Subunit Interaction Dynamics of Class Ia Ribonucleotide Reductases: In Search of a Robust Assay. Biochemistry. PMID 32186371 DOI: 10.1021/Acs.Biochem.0C00001  0.553
2019 Greene BL, Stubbe J, Nocera DG. Selenocysteine Substitution into a Class I Ribonucleotide Reductase. Biochemistry. PMID 31774661 DOI: 10.1021/Acs.Biochem.9B00973  0.761
2019 Thomas WC, Brooks FP, Burnim AA, Bacik JP, Stubbe J, Kaelber JT, Chen JZ, Ando N. Convergent allostery in ribonucleotide reductase. Nature Communications. 10: 2653. PMID 31201319 DOI: 10.1038/S41467-019-10568-4  0.355
2018 Stubbe J, Seyedsayamdost MR. Discovery of a New Class I Ribonucleotide Reductase with an Essential DOPA Radical and NO Metal as an Initiator of Long-Range Radical Transfer. Biochemistry. PMID 30586288 DOI: 10.1021/Acs.Biochem.8B01238  0.571
2018 Greene BL, Stubbe J, Nocera DG. Photochemical Rescue of a Conformationally Inactivated Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 30347141 DOI: 10.1021/Jacs.8B07902  0.739
2018 Greene BL, Nocera DG, Stubbe J. Basis of dATP inhibition of RNRs. The Journal of Biological Chemistry. 293: 10413-10414. PMID 29959279 DOI: 10.1074/Jbc.H118.003717  0.718
2018 Lee W, Kasanmascheff M, Huynh M, Quartararo A, Costentin C, Bejenke I, Nocera DG, Bennati M, Tommos C, Stubbe J. Properties of Site-Specifically Incorporated 3-Aminotyrosine in Proteins To Study Redox-Active Tyrosines: Escherichia coli Ribonucleotide Reductase as a Paradigm. Biochemistry. PMID 29630358 DOI: 10.1021/Acs.Biochem.8B00160  0.535
2018 Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F. 3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife. 7. PMID 29460780 DOI: 10.7554/Elife.31502  0.641
2017 Greene BL, Taguchi AT, Stubbe J, Nocera DG. Conformationally-Dynamic Radical Transfer within Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 29037038 DOI: 10.1021/Jacs.7B08192  0.754
2017 Nick TU, Ravichandran KR, Stubbe J, Kasanmascheff M, Bennati M. Spectroscopic Evidence for a H Bond Network at Y356 Located at the Subunit Interface of Active E. coli Ribonucleotide Reductase. Biochemistry. PMID 28640584 DOI: 10.1021/Acs.Biochem.7B00462  0.353
2017 Li H, Stümpfig M, Zhang C, An X, Stubbe J, Lill R, Huang M. The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements. The Journal of Biological Chemistry. PMID 28515324 DOI: 10.1074/Jbc.M117.786178  0.334
2017 Lin Q, Parker MJ, Taguchi AT, Ravichandran K, Kim A, Kang G, Shao J, Drennan CL, Stubbe J. Glutamate 52-β at the α/β Subunit Interface of E. coli Class Ia Ribonucleotide Reductase is essential for Conformational Gating of Radical Transfer. The Journal of Biological Chemistry. PMID 28377505 DOI: 10.1074/Jbc.M117.783092  0.374
2017 Ravichandran KR, Zong AB, Taguchi AT, Nocera DG, Stubbe J, Tommos C. Formal reduction potentials of difluorotyrosine and trifluorotyrosine protein residues: Defining the thermodynamics of multistep radical transfer. Journal of the American Chemical Society. PMID 28171730 DOI: 10.1021/Jacs.6B11011  0.483
2017 Ravichandran KR, Minnihan EC, Lin Q, Yokoyama K, Taguchi AT, Shao J, Nocera DG, Stubbe J. Glutamate 350 plays an essential role in conformational gating of long range radical transport in E. coli class Ia ribonucleotide reductase. Biochemistry. PMID 28103007 DOI: 10.1021/Acs.Biochem.6B01145  0.492
2016 Kasanmascheff M, Lee W, Nick TU, Stubbe J, Bennati M. Radical transfer in ribonucleotide reductase: a NHY/RA-α mutant unmasks a new conformation of the pathway residue 731. Chemical Science. 7: 2170-2178. PMID 29899944 DOI: 10.1039/C5Sc03460D  0.379
2016 Ravichandran KR, Taguchi AT, Wei Y, Tommos C, Nocera DG, Stubbe J. A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes. Journal of the American Chemical Society. 138: 13706-13716. PMID 28068088 DOI: 10.1021/Jacs.6B08200  0.545
2016 Wittenborn EC, Jost M, Wei Y, Stubbe J, Drennan CL. Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator. The Journal of Biological Chemistry. PMID 27742839 DOI: 10.1074/Jbc.M116.756833  0.365
2016 Ravichandran KR, Taguchi AT, Wei Y, Tommos C, Nocera DG, Stubbe J. A >200 meV uphill thermodynamic landscape for radical transport in E. coli ribonucleotide reductase determined using fluorotyrosine-substituted enzymes. Journal of the American Chemical Society. PMID 27649294 DOI: 10.1021/jacs.6b08200  0.483
2016 Oyala PH, Ravichandran KR, Funk MA, Stucky PA, Stich TA, Drennan CL, Britt RD, Stubbe J. Biophysical characterization of fluorotyrosine probes site-specifically incorporated into enzymes: E. coli ribonucleotide reductase as an example. Journal of the American Chemical Society. PMID 27276098 DOI: 10.1021/Jacs.6B03605  0.636
2016 Olshansky L, Greene BL, Finkbeiner C, Stubbe J, Nocera DG. Photochemical Generation of a Tryptophan Radical within the Subunit Interface of Ribonucleotide Reductase. Biochemistry. PMID 27159163 DOI: 10.1021/Acs.Biochem.6B00292  0.742
2016 Ando N, Li H, Brignole EJ, Thompson S, McLaughlin MI, Page JE, Asturias FJ, Stubbe J, Drennan CL. Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer. Biochemistry. PMID 26727048 DOI: 10.1021/Acs.Biochem.5B01207  0.341
2015 Olshansky L, Stubbe J, Nocera DG. Charge Transfer Dynamics at the α/β Subunit Interface of a Photo-chemical Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 26710997 DOI: 10.1021/Jacs.5B09259  0.534
2015 Song DY, Pizano AA, Holder PG, Stubbe J, Nocera DG. Direct Interfacial Y731 Oxidation in α2 by a Photoβ2 Subunit of E. coli Class Ia Ribonucleotide Reductase. Chemical Science (Royal Society of Chemistry : 2010). 6: 4519-4524. PMID 26504513 DOI: 10.1039/C5Sc01125F  0.554
2015 Ravichandran KR, Minnihan EC, Wei Y, Nocera DG, Stubbe J. Reverse electron transfer completes the catalytic cycle in a 2,3,5-trifluorotyrosine-substituted ribonucleotide reductase. Journal of the American Chemical Society. PMID 26492582 DOI: 10.1021/Jacs.5B09189  0.563
2015 Koo BJ, Huynh M, Halbach RL, Stubbe J, Nocera DG. Modulation of Phenol Oxidation in Cofacial Dyads. Journal of the American Chemical Society. 137: 11860-3. PMID 26305909 DOI: 10.1021/Jacs.5B05955  0.498
2015 Buckley RM, Stubbe J. Chemistry with an artificial primer of polyhydroxybutyrate synthase suggests a mechanism for chain termination. Biochemistry. 54: 2117-25. PMID 25741756 DOI: 10.1021/Bi501405B  0.341
2015 Nick TU, Lee W, Kossmann S, Neese F, Stubbe J, Bennati M. Hydrogen bond network between amino acid radical intermediates on the proton-coupled electron transfer pathway of E. coli α2 ribonucleotide reductase. Journal of the American Chemical Society. 137: 289-98. PMID 25516424 DOI: 10.1021/Ja510513Z  0.413
2015 Song DY, Pizano AA, Holder PG, Stubbe J, Nocera DG. Direct interfacial Y731 oxidation in α2 by a photoβ2 subunit of E. coli class Ia ribonucleotide reductase Chemical Science. 6: 4519-4524. DOI: 10.1039/c5sc01125f  0.44
2014 Olshansky L, Pizano AA, Wei Y, Stubbe J, Nocera DG. Kinetics of hydrogen atom abstraction from substrate by an active site thiyl radical in ribonucleotide reductase. Journal of the American Chemical Society. 136: 16210-6. PMID 25353063 DOI: 10.1021/Ja507313W  0.55
2014 Wei Y, Funk MA, Rosado LA, Baek J, Drennan CL, Stubbe J. The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant. Proceedings of the National Academy of Sciences of the United States of America. 111: E3756-65. PMID 25157154 DOI: 10.1073/Pnas.1414396111  0.609
2014 Wei Y, Mathies G, Yokoyama K, Chen J, Griffin RG, Stubbe J. A chemically competent thiosulfuranyl radical on the Escherichia coli class III ribonucleotide reductase. Journal of the American Chemical Society. 136: 9001-13. PMID 24827372 DOI: 10.1021/Ja5030194  0.427
2014 Zhang Y, Li H, Zhang C, An X, Liu L, Stubbe J, Huang M. Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proceedings of the National Academy of Sciences of the United States of America. 111: E1695-704. PMID 24733891 DOI: 10.1073/Pnas.1405204111  0.371
2014 Parker MJ, Zhu X, Stubbe J. Bacillus subtilis class Ib ribonucleotide reductase: high activity and dynamic subunit interactions. Biochemistry. 53: 766-76. PMID 24401092 DOI: 10.1021/Bi401056E  0.387
2013 Ravichandran KR, Liang L, Stubbe J, Tommos C. Formal reduction potential of 3,5-difluorotyrosine in a structured protein: insight into multistep radical transfer. Biochemistry. 52: 8907-15. PMID 24228716 DOI: 10.1021/Bi401494F  0.387
2013 Pizano AA, Olshansky L, Holder PG, Stubbe J, Nocera DG. Modulation of Y356 photooxidation in E. coli class Ia ribonucleotide reductase by Y731 across the α2:β2 interface. Journal of the American Chemical Society. 135: 13250-3. PMID 23927429 DOI: 10.1021/Ja405498E  0.572
2013 Minnihan EC, Nocera DG, Stubbe J. Reversible, long-range radical transfer in E. coli class Ia ribonucleotide reductase. Accounts of Chemical Research. 46: 2524-35. PMID 23730940 DOI: 10.1021/Ar4000407  0.608
2013 Wörsdörfer B, Conner DA, Yokoyama K, Livada J, Seyedsayamdost M, Jiang W, Silakov A, Stubbe J, Bollinger JM, Krebs C. Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer. Journal of the American Chemical Society. 135: 8585-93. PMID 23676140 DOI: 10.1021/Ja401342S  0.811
2013 Offenbacher AR, Minnihan EC, Stubbe J, Barry BA. Redox-linked changes to the hydrogen-bonding network of ribonucleotide reductase β2. Journal of the American Chemical Society. 135: 6380-3. PMID 23594029 DOI: 10.1021/Ja3032949  0.383
2013 Zhang Y, An X, Stubbe J, Huang M. Investigation of in vivo roles of the C-terminal tails of the small subunit (ββ') of Saccharomyces cerevisiae ribonucleotide reductase: contribution to cofactor formation and intersubunit association within the active holoenzyme. The Journal of Biological Chemistry. 288: 13951-9. PMID 23532842 DOI: 10.1074/Jbc.M113.467001  0.406
2013 Minnihan EC, Ando N, Brignole EJ, Olshansky L, Chittuluru J, Asturias FJ, Drennan CL, Nocera DG, Stubbe J. Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 110: 3835-40. PMID 23431160 DOI: 10.1073/Pnas.1220691110  0.6
2013 Cotruvo JA, Stich TA, Britt RD, Stubbe J. Mechanism of assembly of the dimanganese-tyrosyl radical cofactor of class Ib ribonucleotide reductase: enzymatic generation of superoxide is required for tyrosine oxidation via a Mn(III)Mn(IV) intermediate. Journal of the American Chemical Society. 135: 4027-39. PMID 23402532 DOI: 10.1021/Ja312457T  0.628
2012 Argirevi? T, Riplinger C, Stubbe J, Neese F, Bennati M. ENDOR spectroscopy and DFT calculations: evidence for the hydrogen-bond network within α2 in the PCET of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 134: 17661-70. PMID 23072506 DOI: 10.1021/Ja3071682  0.401
2012 Cotruvo JA, Stubbe J. Metallation and mismetallation of iron and manganese proteins in vitro and in vivo: the class I ribonucleotide reductases as a case study. Metallomics : Integrated Biometal Science. 4: 1020-36. PMID 22991063 DOI: 10.1039/C2Mt20142A  0.622
2012 Aye Y, Long MJ, Stubbe J. Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species. The Journal of Biological Chemistry. 287: 35768-78. PMID 22915594 DOI: 10.1074/Jbc.M112.396911  0.648
2012 Aye Y, Brignole EJ, Long MJ, Chittuluru J, Drennan CL, Asturias FJ, Stubbe J. Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers. Chemistry & Biology. 19: 799-805. PMID 22840768 DOI: 10.1016/J.Chembiol.2012.05.015  0.637
2012 Zimanyi CM, Ando N, Brignole EJ, Asturias FJ, Stubbe J, Drennan CL. Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase. Structure (London, England : 1993). 20: 1374-83. PMID 22727814 DOI: 10.1016/J.Str.2012.05.009  0.338
2012 Boal AK, Cotruvo JA, Stubbe J, Rosenzweig AC. The dimanganese(II) site of Bacillus subtilis class Ib ribonucleotide reductase. Biochemistry. 51: 3861-71. PMID 22443445 DOI: 10.1021/Bi201925T  0.637
2012 Cho M, Brigham CJ, Sinskey AJ, Stubbe J. Purification of polyhydroxybutyrate synthase from its native organism, Ralstonia eutropha: implications for the initiation and elongation of polymer formation in vivo. Biochemistry. 51: 2276-88. PMID 22369488 DOI: 10.1021/Bi2013596  0.343
2012 Pizano AA, Lutterman DA, Holder PG, Teets TS, Stubbe J, Nocera DG. Photo-ribonucleotide reductase β2 by selective cysteine labeling with a radical phototrigger. Proceedings of the National Academy of Sciences of the United States of America. 109: 39-43. PMID 22171005 DOI: 10.1073/Pnas.1115778108  0.556
2012 Holder PG, Pizano AA, Anderson BL, Stubbe J, Nocera DG. Deciphering radical transport in the large subunit of class I ribonucleotide reductase. Journal of the American Chemical Society. 134: 1172-80. PMID 22121977 DOI: 10.1021/Ja209016J  0.542
2011 Ando N, Brignole EJ, Zimanyi CM, Funk MA, Yokoyama K, Asturias FJ, Stubbe J, Drennan CL. Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 108: 21046-51. PMID 22160671 DOI: 10.1073/Pnas.1112715108  0.632
2011 Yokoyama K, Smith AA, Corzilius B, Griffin RG, Stubbe J. Equilibration of tyrosyl radicals (Y356•, Y731•, Y730•) in the radical propagation pathway of the Escherichia coli class Ia ribonucleotide reductase. Journal of the American Chemical Society. 133: 18420-32. PMID 21967342 DOI: 10.1021/Ja207455K  0.402
2011 Zhang Y, Liu L, Wu X, An X, Stubbe J, Huang M. Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins. The Journal of Biological Chemistry. 286: 41499-509. PMID 21931161 DOI: 10.1074/Jbc.M111.294074  0.33
2011 Minnihan EC, Young DD, Schultz PG, Stubbe J. Incorporation of fluorotyrosines into ribonucleotide reductase using an evolved, polyspecific aminoacyl-tRNA synthetase. Journal of the American Chemical Society. 133: 15942-5. PMID 21913683 DOI: 10.1021/Ja207719F  0.501
2011 Aye Y, Stubbe J. Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit. Proceedings of the National Academy of Sciences of the United States of America. 108: 9815-20. PMID 21628579 DOI: 10.1073/Pnas.1013274108  0.649
2011 Minnihan EC, Seyedsayamdost MR, Uhlin U, Stubbe J. Kinetics of radical intermediate formation and deoxynucleotide production in 3-aminotyrosine-substituted Escherichia coli ribonucleotide reductases. Journal of the American Chemical Society. 133: 9430-40. PMID 21612216 DOI: 10.1021/Ja201640N  0.677
2011 Zhang Y, Stubbe J. Bacillus subtilis class Ib ribonucleotide reductase is a dimanganese(III)-tyrosyl radical enzyme. Biochemistry. 50: 5615-23. PMID 21561096 DOI: 10.1021/Bi200348Q  0.385
2011 Stubbe J. Biochemistry. The two faces of SAM. Science (New York, N.Y.). 332: 544-5. PMID 21527702 DOI: 10.1126/Science.1204209  0.339
2011 Cotruvo JA, Stubbe J. Class I ribonucleotide reductases: metallocofactor assembly and repair in vitro and in vivo. Annual Review of Biochemistry. 80: 733-67. PMID 21456967 DOI: 10.1146/Annurev-Biochem-061408-095817  0.633
2011 Cotruvo JA, Stubbe J. Escherichia coli class Ib ribonucleotide reductase contains a dimanganese(III)-tyrosyl radical cofactor in vivo. Biochemistry. 50: 1672-81. PMID 21250660 DOI: 10.1021/Bi101881D  0.655
2011 Stubbe J, Cotruvo JA. Control of metallation and active cofactor assembly in the class Ia and Ib ribonucleotide reductases: diiron or dimanganese? Current Opinion in Chemical Biology. 15: 284-90. PMID 21216656 DOI: 10.1016/J.Cbpa.2010.12.001  0.645
2011 Seyedsayamdost MR, Yee CS, Stubbe J. Use of 2,3,5-F(3)Y-β2 and 3-NH(2)Y-α2 to study proton-coupled electron transfer in Escherichia coli ribonucleotide reductase. Biochemistry. 50: 1403-11. PMID 21182280 DOI: 10.1021/Bi101319V  0.655
2011 Holder PG, Nocera DG, Francis MB, Stubbe J. Guiding and measuring electron transfers in biomolecules: Lessons for photovoltaics, materials, and medicine Acs National Meeting Book of Abstracts 0.358
2010 Yokoyama K, Uhlin U, Stubbe J. A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase. Journal of the American Chemical Society. 132: 15368-79. PMID 20929229 DOI: 10.1021/Ja1069344  0.438
2010 Boal AK, Cotruvo JA, Stubbe J, Rosenzweig AC. Structural basis for activation of class Ib ribonucleotide reductase. Science (New York, N.Y.). 329: 1526-30. PMID 20688982 DOI: 10.1126/Science.1190187  0.632
2010 Yokoyama K, Uhlin U, Stubbe J. Site-specific incorporation of 3-nitrotyrosine as a probe of pKa perturbation of redox-active tyrosines in ribonucleotide reductase. Journal of the American Chemical Society. 132: 8385-97. PMID 20518462 DOI: 10.1021/Ja101097P  0.4
2010 Lohman GJ, Stubbe J. Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: covalent modification. Biochemistry. 49: 1404-17. PMID 20088569 DOI: 10.1021/Bi902132U  0.306
2010 Lohman GJ, Gerfen GJ, Stubbe J. Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: adenosylcobalamin destruction and formation of a nucleotide-based radical. Biochemistry. 49: 1396-403. PMID 20088568 DOI: 10.1021/Bi9021318  0.375
2010 Cotruvo JA, Stubbe J. An active dimanganese(III)-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Biochemistry. 49: 1297-309. PMID 20070127 DOI: 10.1021/Bi902106N  0.661
2010 Sicoli G, Argirevi? T, Stubbe J, Tkach I, Bennati M. Effects in 94 GHz orientation-selected PELDOR on a rigid pair of radicals with Non-collinear axes Applied Magnetic Resonance. 37: 539-548. DOI: 10.1007/S00723-009-0094-3  0.357
2009 Minnihan EC, Seyedsayamdost MR, Stubbe J. Use of 3-aminotyrosine to examine the pathway dependence of radical propagation in Escherichia coli ribonucleotide reductase. Biochemistry. 48: 12125-32. PMID 19916558 DOI: 10.1021/Bi901439W  0.646
2009 Wang J, Lohman GJ, Stubbe J. Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5'-diphosphate. Biochemistry. 48: 11612-21. PMID 19899807 DOI: 10.1021/Bi901588Z  0.336
2009 Artin E, Wang J, Lohman GJ, Yokoyama K, Yu G, Griffin RG, Bar G, Stubbe J. Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant. Biochemistry. 48: 11622-9. PMID 19899770 DOI: 10.1021/Bi901590Q  0.402
2009 Seyedsayamdost MR, Argirevi? T, Minnihan EC, Stubbe J, Bennati M. Structural examination of the transient 3-aminotyrosyl radical on the PCET pathway of E. coli ribonucleotide reductase by multifrequency EPR spectroscopy. Journal of the American Chemical Society. 131: 15729-38. PMID 19821570 DOI: 10.1021/Ja903879W  0.672
2009 Li P, Chakraborty S, Stubbe J. Detection of covalent and noncovalent intermediates in the polymerization reaction catalyzed by a C149S class III polyhydroxybutyrate synthase. Biochemistry. 48: 9202-11. PMID 19711985 DOI: 10.1021/Bi901329B  0.35
2009 Seyedsayamdost MR, Stubbe J. Replacement of Y730 and Y731 in the alpha2 subunit of Escherichia coli ribonucleotide reductase with 3-aminotyrosine using an evolved suppressor tRNA/tRNA-synthetase pair. Methods in Enzymology. 462: 45-76. PMID 19632469 DOI: 10.1016/S0076-6879(09)62003-6  0.663
2009 Offenbacher AR, Vassiliev IR, Seyedsayamdost MR, Stubbe J, Barry BA. Redox-linked structural changes in ribonucleotide reductase. Journal of the American Chemical Society. 131: 7496-7. PMID 19489635 DOI: 10.1021/Ja901908J  0.642
2009 Reece SY, Lutterman DA, Seyedsayamdost MR, Stubbe J, Nocera DG. Re(bpy)(CO)3CN as a probe of conformational flexibility in a photochemical ribonucleotide reductase. Biochemistry. 48: 5832-8. PMID 19402704 DOI: 10.1021/Bi9005804  0.68
2008 Marletta MA, Stubbe J. Catalysis and regulation. Editorial overview. Current Opinion in Structural Biology. 18: 641-3. PMID 19059103 DOI: 10.1016/J.Sbi.2008.11.006  0.479
2008 Hassan AQ, Wang Y, Plate L, Stubbe J. Methodology to probe subunit interactions in ribonucleotide reductases. Biochemistry. 47: 13046-55. PMID 19012414 DOI: 10.1021/Bi8012559  0.304
2008 Cotruvo JA, Stubbe J. NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 105: 14383-8. PMID 18799738 DOI: 10.1073/Pnas.0807348105  0.652
2008 Morar M, Hoskins AA, Stubbe J, Ealick SE. Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation. Biochemistry. 47: 7816-30. PMID 18597481 DOI: 10.1021/Bi800329P  0.682
2008 Chen J, Ghorai MK, Kenney G, Stubbe J. Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage. Nucleic Acids Research. 36: 3781-90. PMID 18492718 DOI: 10.1093/Nar/Gkn302  0.609
2008 Hristova D, Wu CH, Jiang W, Krebs C, Stubbe J. Importance of the maintenance pathway in the regulation of the activity of Escherichia coli ribonucleotide reductase. Biochemistry. 47: 3989-99. PMID 18314964 DOI: 10.1021/Bi702408K  0.58
2008 Chen J, Dupradeau FY, Case DA, Turner CJ, Stubbe J. DNA oligonucleotides with A, T, G or C opposite an abasic site: structure and dynamics. Nucleic Acids Research. 36: 253-62. PMID 18025040 DOI: 10.1093/Nar/Gkm622  0.317
2007 Seyedsayamdost MR, Chan CT, Mugnaini V, Stubbe J, Bennati M. PELDOR spectroscopy with DOPA-beta2 and NH2Y-alpha2s: distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 129: 15748-9. PMID 18047343 DOI: 10.1021/Ja076459B  0.645
2007 Seyedsayamdost MR, Xie J, Chan CT, Schultz PG, Stubbe J. Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation. Journal of the American Chemical Society. 129: 15060-71. PMID 17990884 DOI: 10.1021/Ja076043Y  0.712
2007 Reece SY, Seyedsayamdost MR, Stubbe J, Nocera DG. Direct observation of a transient tyrosine radical competent for initiating turnover in a photochemical ribonucleotide reductase. Journal of the American Chemical Society. 129: 13828-30. PMID 17944464 DOI: 10.1021/Ja074452O  0.669
2007 Wu CH, Jiang W, Krebs C, Stubbe J. YfaE, a ferredoxin involved in diferric-tyrosyl radical maintenance in Escherichia coli ribonucleotide reductase. Biochemistry. 46: 11577-88. PMID 17880186 DOI: 10.1021/Bi7012454  0.581
2007 Wang J, Lohman GJ, Stubbe J. Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases. Proceedings of the National Academy of Sciences of the United States of America. 104: 14324-9. PMID 17726094 DOI: 10.1073/Pnas.0706803104  0.357
2007 Reece SY, Seyedsayamdost MR, Stubbe J, Nocera DG. Photoactive peptides for light-initiated tyrosyl radical generation and transport into ribonucleotide reductase. Journal of the American Chemical Society. 129: 8500-9. PMID 17567129 DOI: 10.1021/Ja0704434  0.699
2007 Seyedsayamdost MR, Yee CS, Stubbe J. Site-specific incorporation of fluorotyrosines into the R2 subunit of E. coli ribonucleotide reductase by expressed protein ligation. Nature Protocols. 2: 1225-35. PMID 17546018 DOI: 10.1038/Nprot.2007.159  0.591
2007 Chen J, Dupradeau FY, Case DA, Turner CJ, Stubbe J. Nuclear magnetic resonance structural studies and molecular modeling of duplex DNA containing normal and 4'-oxidized abasic sites. Biochemistry. 46: 3096-107. PMID 17323932 DOI: 10.1021/Bi6024269  0.343
2007 Hoskins AA, Morar M, Kappock TJ, Mathews II, Zaugg JB, Barder TE, Peng P, Okamoto A, Ealick SE, Stubbe J. N5-CAIR mutase: role of a CO2 binding site and substrate movement in catalysis. Biochemistry. 46: 2842-55. PMID 17298082 DOI: 10.1021/Bi602436G  0.693
2007 Seyedsayamdost MR, Stubbe J. Forward and reverse electron transfer with the Y356DOPA-beta2 heterodimer of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 129: 2226-7. PMID 17279757 DOI: 10.1021/Ja0685607  0.622
2006 Morar M, Anand R, Hoskins AA, Stubbe J, Ealick SE. Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily. Biochemistry. 45: 14880-95. PMID 17154526 DOI: 10.1021/Bi061591U  0.696
2006 Reece SY, Seyedsayamdost MR, Stubbe J, Nocera DG. Electron transfer reactions of fluorotyrosyl radicals. Journal of the American Chemical Society. 128: 13654-5. PMID 17044670 DOI: 10.1021/Ja0636688  0.645
2006 Ortigosa AD, Hristova D, Perlstein DL, Zhang Z, Huang M, Stubbe J. Determination of the in vivo stoichiometry of tyrosyl radical per betabeta' in Saccharomyces cerevisiae ribonucleotide reductase. Biochemistry. 45: 12282-94. PMID 17014081 DOI: 10.1021/Bi0610404  0.766
2006 Denysenkov VP, Prisner TF, Stubbe J, Bennati M. High-field pulsed electron-electron double resonance spectroscopy to determine the orientation of the tyrosyl radicals in ribonucleotide reductase Proceedings of the National Academy of Sciences of the United States of America. 103: 13386-13390. PMID 16938868 DOI: 10.1073/Pnas.0605851103  0.39
2006 Reece SY, Hodgkiss JM, Stubbe J, Nocera DG. Proton-coupled electron transfer: the mechanistic underpinning for radical transport and catalysis in biology. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 361: 1351-64. PMID 16873123 DOI: 10.1098/Rstb.2006.1874  0.552
2006 Seyedsayamdost MR, Stubbe J. Site-specific replacement of Y356 with 3,4-dihydroxyphenylalanine in the beta2 subunit of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 128: 2522-3. PMID 16492021 DOI: 10.1021/Ja057776Q  0.662
2006 Seyedsayamdost MR, Reece SY, Nocera DG, Stubbe J. Mono-, di-, tri-, and tetra-substituted fluorotyrosines: new probes for enzymes that use tyrosyl radicals in catalysis. Journal of the American Chemical Society. 128: 1569-79. PMID 16448128 DOI: 10.1021/Ja055926R  0.678
2006 Seyedsayamdost MR, Yee CS, Reece SY, Nocera DG, Stubbe J. pH Rate profiles of FnY356-R2s (n = 2, 3, 4) in Escherichia coli ribonucleotide reductase: evidence that Y356 is a redox-active amino acid along the radical propagation pathway. Journal of the American Chemical Society. 128: 1562-8. PMID 16448127 DOI: 10.1021/Ja055927J  0.704
2006 Zhang Z, An X, Yang K, Perlstein DL, Hicks L, Kelleher N, Stubbe J, Huang M. Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Proceedings of the National Academy of Sciences of the United States of America. 103: 1422-7. PMID 16432237 DOI: 10.1073/Pnas.0510516103  0.76
2005 Perlstein DL, Ge J, Ortigosa AD, Robblee JH, Zhang Z, Huang M, Stubbe J. The active form of the Saccharomyces cerevisiae ribonucleotide reductase small subunit is a heterodimer in vitro and in vivo. Biochemistry. 44: 15366-77. PMID 16285741 DOI: 10.1021/Bi051616+  0.745
2005 Bennati M, Robblee JH, Mugnaini V, Stubbe J, Freed JH, Borbat P. EPR distance measurements support a model for long-range radical initiation in E. coli ribonucleotide reductase. Journal of the American Chemical Society. 127: 15014-5. PMID 16248626 DOI: 10.1021/Ja054991Y  0.368
2005 Lawrence AG, Choi J, Rha C, Stubbe J, Sinskey AJ. In vitro analysis of the chain termination reaction in the synthesis of poly-(R)-beta-hydroxybutyrate by the class III synthase from Allochromatium vinosum. Biomacromolecules. 6: 2113-9. PMID 16004452 DOI: 10.1021/Bm0501048  0.373
2005 Tian J, Sinskey AJ, Stubbe J. Class III polyhydroxybutyrate synthase: Involvement in chain termination and reinitiation Biochemistry. 44: 8369-8377. PMID 15938626 DOI: 10.1021/Bi050331U  0.347
2005 Fritscher J, Artin E, Wnuk S, Bar G, Robblee JH, Kacprzak S, Kaupp M, Griffin RG, Bennati M, Stubbe J. Structure of the nitrogen-centered radical formed during inactivation of E. coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine-5'-diphosphate: trapping of the 3'-ketonucleotide. Journal of the American Chemical Society. 127: 7729-38. PMID 15913363 DOI: 10.1021/Ja043111X  0.364
2005 Tian J, He A, Lawrence AG, Liu P, Watson N, Sinskey AJ, Stubbe J. Analysis of transient polyhydroxybutyrate production in Wautersia eutropha H16 by quantitative Western analysis and transmission electron microscopy. Journal of Bacteriology. 187: 3825-32. PMID 15901707 DOI: 10.1128/Jb.187.11.3825-3832.2005  0.303
2005 Reece SY, Stubbe J, Nocera DG. pH Dependence of charge transfer between tryptophan and tyrosine in dipeptides. Biochimica Et Biophysica Acta. 1706: 232-8. PMID 15694351 DOI: 10.1016/J.Bbabio.2004.11.011  0.471
2005 Tian J, Sinskey AJ, Stubbe J. Detection of intermediates from the polymerization reaction catalyzed by a D302A mutant of class III polyhydroxyalkanoate (PHA) synthase Biochemistry. 44: 1495-1503. PMID 15683234 DOI: 10.1021/Bi047734Z  0.378
2005 Davydov R, Behrouzian B, Smoukov S, Stubbe J, Hoffman BM, Shanklin J. Effect of substrate on the diiron(III) site in stearoyl acyl carrier protein Δ9-desaturase as disclosed by cryoreduction electron paramagnetic resonance/electron nuclear double resonance spectroscopy Biochemistry. 44: 1309-1315. PMID 15667224 DOI: 10.1021/Bi048599T  0.375
2005 Denysenkov VP, Prisner TF, Stubbe J, Bennati M. High-frequency 180 GHz PELDOR Applied Magnetic Resonance. 29: 375-384. DOI: 10.1007/Bf03167024  0.307
2004 Chang MC, Yee CS, Nocera DG, Stubbe J. Site-specific replacement of a conserved tyrosine in ribonucleotide reductase with an aniline amino acid: a mechanistic probe for a redox-active tyrosine. Journal of the American Chemical Society. 126: 16702-3. PMID 15612690 DOI: 10.1021/Ja044124D  0.676
2004 Anand R, Hoskins AA, Bennett EM, Sintchak MD, Stubbe J, Ealick SE. A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex. Biochemistry. 43: 10343-52. PMID 15301532 DOI: 10.1021/Bi0491292  0.699
2004 Anand R, Hoskins AA, Stubbe J, Ealick SE. Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography. Biochemistry. 43: 10328-42. PMID 15301531 DOI: 10.1021/Bi0491301  0.682
2004 Hoskins AA, Anand R, Ealick SE, Stubbe J. The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation. Biochemistry. 43: 10314-27. PMID 15301530 DOI: 10.1021/Bi049127H  0.692
2004 Sommerhalter M, Voegtli WC, Perlstein DL, Ge J, Stubbe J, Rosenzweig AC. Structures of the yeast ribonucleotide reductase Rnr2 and Rnr4 homodimers. Biochemistry. 43: 7736-42. PMID 15196016 DOI: 10.1021/Bi049510M  0.757
2004 Chang MC, Yee CS, Stubbe J, Nocera DG. Turning on ribonucleotide reductase by light-initiated amino acid radical generation. Proceedings of the National Academy of Sciences of the United States of America. 101: 6882-7. PMID 15123822 DOI: 10.1073/Pnas.0401718101  0.691
2004 Chen J, Stubbe J. Synthesis and Characterization of Oligonucleotides Containing a 4′-Keto Abasic Site Biochemistry. 43: 5278-5286. PMID 15122893 DOI: 10.1021/Bi0495376  0.334
2003 Yee CS, Seyedsayamdost MR, Chang MC, Nocera DG, Stubbe J. Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process. Biochemistry. 42: 14541-52. PMID 14661967 DOI: 10.1021/Bi0352365  0.754
2003 Bennati M, Weber A, Antonic J, Perlstein DL, Robblee J, Stubbe J. Pulsed ELDOR Spectroscopy Measures the Distance between the Two Tyrosyl Radicals in the R2 Subunit of the E. coli Ribonucleotide Reductase Journal of the American Chemical Society. 125: 14988-14989. PMID 14653724 DOI: 10.1021/Ja0362095  0.76
2003 Yee CS, Chang MC, Ge J, Nocera DG, Stubbe J. 2,3-difluorotyrosine at position 356 of ribonucleotide reductase R2: a probe of long-range proton-coupled electron transfer. Journal of the American Chemical Society. 125: 10506-7. PMID 12940718 DOI: 10.1021/Ja036242R  0.672
2003 Ge J, Yu G, Ator MA, Stubbe J. Pre-steady-state and steady-state kinetic analysis of E. coli class I ribonucleotide reductase Biochemistry. 42: 10071-10083. PMID 12939135 DOI: 10.1021/Bi034374R  0.367
2003 Stubbe J, Nocera DG, Yee CS, Chang MC. Radical initiation in the class I ribonucleotide reductase: long-range proton-coupled electron transfer? Chemical Reviews. 103: 2167-201. PMID 12797828 DOI: 10.1021/Cr020421U  0.641
2003 Yao R, Zhang Z, An X, Bucci B, Perlstein DL, Stubbe J, Huang M. Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways Proceedings of the National Academy of Sciences of the United States of America. 100: 6628-6633. PMID 12732713 DOI: 10.1073/Pnas.1131932100  0.74
2003 Stubbe J. Di-iron-tyrosyl radical ribonucleotide reductases. Current Opinion in Chemical Biology. 7: 183-188. PMID 12714050 DOI: 10.1016/S1367-5931(03)00025-5  0.357
2003 Chen D, Abend A, Stubbe J, Frey PA. Epimerization at carbon-5' of (5'R)-[5'-2H]adenosylcobalamin by ribonucleoside triphosphate reductase: cysteine 408-independent cleavage of the Co-C5' bond. Biochemistry. 42: 4578-84. PMID 12693955 DOI: 10.1021/Bi030018X  0.558
2003 Stubbe J. Radicals with a controlled lifestyle Chemical Communications. 9: 2511-2513. DOI: 10.1039/B307617M  0.31
2002 Chang MC, Miller SE, Carpenter SD, Stubbe J, Nocera DG. Nanosecond generation of tyrosyl radicals via laser-initiated decaging of oxalate-modified amino acids. The Journal of Organic Chemistry. 67: 6820-2. PMID 12227817 DOI: 10.1021/Jo025569S  0.643
2002 Sintchak MD, Arjara G, Kellogg BA, Stubbe J, Drennan CL. The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer. Nature Structural Biology. 9: 293-300. PMID 11875520 DOI: 10.1038/Nsb774  0.33
2001 Yuan W, Jia Y, Tian J, Snell KD, Müh U, Sinskey AJ, Lambalot RH, Walsh CT, Stubbe J. Class I and III polyhydroxyalkanoate synthases from Ralstonia eutropha and Allochromatium vinosum: characterization and substrate specificity studies. Archives of Biochemistry and Biophysics. 394: 87-98. PMID 11566031 DOI: 10.1006/Abbi.2001.2522  0.514
2001 Voegtli WC, Ge J, Perlstein DL, Stubbe J, Rosenzweig AC. Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer. Proceedings of the National Academy of Sciences of the United States of America. 98: 10073-8. PMID 11526233 DOI: 10.1073/Pnas.181336398  0.781
2001 Ge J, Perlstein DL, Nguyen HH, Bar G, Griffin RG, Stubbe J. Why multiple small subunits (Y2 and Y4) for yeast ribonucleotide reductase? Toward understanding the role of Y4 Proceedings of the National Academy of Sciences of the United States of America. 98: 10067-10072. PMID 11526232 DOI: 10.1073/Pnas.181336498  0.769
2001 Hoehn ST, Turner CJ, Stubbe J. Solution structure of an oligonucleotide containing an abasic site: evidence for an unusual deoxyribose conformation. Nucleic Acids Research. 29: 3413-23. PMID 11504879 DOI: 10.1093/Nar/29.16.3413  0.315
2001 Bar G, Bennati M, Nguyen HH, Ge J, Stubbe JA, Griffin RG. High-frequency (140-GHz) time domain EPR and ENDOR spectroscopy: the tyrosyl radical-diiron cofactor in ribonucleotide reductase from yeast. Journal of the American Chemical Society. 123: 3569-76. PMID 11472128 DOI: 10.1021/Ja003108N  0.387
2001 Hoehn ST, Junker HD, Bunt RC, Turner CJ, Stubbe J. Solution structure of Co(III)-bleomycin-OOH bound to a phosphoglycolate lesion containing oligonucleotide: implications for bleomycin-induced double-strand DNA cleavage. Biochemistry. 40: 5894-905. PMID 11352724 DOI: 10.1021/Bi002635G  0.344
2001 Zilles JL, Kappock TJ, Stubbe J, Downs DM. Altered pathway routing in a class of Salmonella enterica serovar Typhimurium mutants defective in aminoimidazole ribonucleotide synthetase. Journal of Bacteriology. 183: 2234-40. PMID 11244062 DOI: 10.1128/Jb.183.7.2234-2240.2001  0.321
2001 Jia Y, Yuan W, Wodzinska J, Park C, Sinskey AJ, Stubbe J. Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism. Biochemistry. 40: 1011-9. PMID 11170423 DOI: 10.1021/Bi002219W  0.423
2001 Stubbe J, Ge J, Yee CS. The evolution of ribonucleotide reduction revisited Trends in Biochemical Sciences. 26: 93-99. PMID 11166566 DOI: 10.1016/S0968-0004(00)01764-3  0.373
2001 Bennati M, Stubbe J, Griffin RG. High-frequency EPR and ENDOR: Time-domain spectroscopy of ribonucleotide reductase Applied Magnetic Resonance. 21: 389-410. DOI: 10.1007/Bf03162416  0.338
2000 Stubbe J. Ribonucleotide reductases: the link between an RNA and a DNA world? Current Opinion in Structural Biology. 10: 731-736. PMID 11114511 DOI: 10.1016/S0959-440X(00)00153-6  0.331
2000 Harsch A, Marzilli LA, Bunt RC, Stubbe J, Vouros P. Accurate and rapid modeling of iron-bleomycin-induced DNA damage using tethered duplex oligonucleotides and electrospray ionization ion trap mass spectrometric analysis. Nucleic Acids Research. 28: 1978-85. PMID 10756200 DOI: 10.1093/Nar/28.9.1978  0.325
2000 Jia Y, Kappock TJ, Frick T, Sinskey AJ, Stubbe J. Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: characterization of the functional residues in Chromatium vinosum PHB synthase. Biochemistry. 39: 3927-36. PMID 10747780 DOI: 10.1021/Bi9928086  0.379
1999 Mathews II, Kappock TJ, Stubbe J, Ealick SE. Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway. Structure (London, England : 1993). 7: 1395-406. PMID 10574791 DOI: 10.1016/S0969-2126(00)80029-5  0.341
1999 Nguyen HHT, Ge J, Perlstein DL, Stubbe J. Purification of ribonucleotide reductase subunits Y1, Y2, Y3, and Y4 from yeast: Y4 plays a key role in diiron cluster assembly Proceedings of the National Academy of Sciences of the United States of America. 96: 12339-12344. PMID 10535923 DOI: 10.1073/Pnas.96.22.12339  0.766
1999 Li C, Kappock TJ, Stubbe J, Weaver TM, Ealick SE. X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution. Structure (London, England : 1993). 7: 1155-66. PMID 10508786 DOI: 10.1016/S0969-2126(99)80182-8  0.378
1999 Lawrence CC, Bennati M, Obias HV, Bar G, Griffin RG, Stubbe J. High-field EPR detection of a disulfide radical anion in the reduction of cytidine 5'-diphosphate by the E441Q R1 mutant of Escherichia coli ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 96: 8979-84. PMID 10430881 DOI: 10.1073/Pnas.96.16.8979  0.427
1999 Bennati M, Farrar CT, Bryant JA, Inati SJ, Weis V, Gerfen GJ, Riggs-Gelasco P, Stubbe J, Griffin RG. Pulsed electron-nuclear double resonance (ENDOR) at 140 GHz. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 138: 232-43. PMID 10341127 DOI: 10.1006/Jmre.1999.1727  0.711
1999 Licht SS, Lawrence CC, Stubbe J. Thermodynamic and kinetic studies on carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: the importance of entropy in catalysis. Biochemistry. 38: 1234-42. PMID 9930983 DOI: 10.1021/Bi981886A  0.566
1999 Licht SS, Booker S, Stubbe J. Studies on the catalysis of carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: evidence for concerted carbon-cobalt bond homolysis and thiyl radical formation. Biochemistry. 38: 1221-33. PMID 9930982 DOI: 10.1021/Bi981885I  0.716
1999 Müh U, Sinskey AJ, Kirby DP, Lane WS, Stubbe J. PHA synthase from chromatium vinosum: cysteine 149 is involved in covalent catalysis. Biochemistry. 38: 826-37. PMID 9888824 DOI: 10.1021/Bi9818319  0.348
1999 Licht SS, Lawrence CC, Stubbe J. Class II ribonucleotide reductases catalyze carbon-cobalt bond reformation on every turnover Journal of the American Chemical Society. 121: X. DOI: 10.1021/Ja9913840  0.581
1998 Stubbe J, van Der Donk WA. Protein Radicals in Enzyme Catalysis. [Chem. Rev. 1998, 98, 705minus sign762. Chemical Reviews. 98: 2661-2662. PMID 11848974 DOI: 10.1021/Cr980059C  0.563
1998 Stubbe J, van Der Donk WA. Protein Radicals in Enzyme Catalysis. Chemical Reviews. 98: 705-762. PMID 11848913  0.505
1998 Stubbe J, Riggs-Gelasco P. Harnessing free radicals: formation and function of the tyrosyl radical in ribonucleotide reductase Trends in Biochemical Sciences. 23: 438-443. PMID 9852763 DOI: 10.1016/S0968-0004(98)01296-1  0.757
1998 Wang W, Kappock TJ, Stubbe J, Ealick SE. X-ray crystal structure of glycinamide ribonucleotide synthetase from Escherichia coli. Biochemistry. 37: 15647-62. PMID 9843369 DOI: 10.1021/Bi981405N  0.341
1998 Lawrence CC, Stubbe J. The function of adenosylcobalamin in the mechanism of ribonucleoside triphosphate reductase from Lactobacillus leichmannii. Current Opinion in Chemical Biology. 2: 650-655. PMID 9818192 DOI: 10.1016/S1367-5931(98)80097-5  0.368
1998 van der Donk WA, Yu G, Pérez L, Sanchez RJ, Stubbe J, Samano V, Robins MJ. Detection of a new substrate-derived radical during inactivation of ribonucleotide reductase from Escherichia coli by gemcitabine 5'-diphosphate. Biochemistry. 37: 6419-26. PMID 9572859 DOI: 10.1021/Bi9729357  0.592
1998 Tong W, Burdi D, Riggs-Gelasco P, Chen S, Edmondson D, Huynh BH, Stubbe J, Han S, Arvai A, Tainer J. Characterization of Y122F R2 of Escherichia coli ribonucleotide reductase by time-resolved physical biochemical methods and X-ray crystallography. Biochemistry. 37: 5840-8. PMID 9558317 DOI: 10.1021/Bi9728811  0.752
1998 Silva DJ, Stubbe J, Samano V, Robins MJ. Gemcitabine 5'-triphosphate is a stoichiometric mechanism-based inhibitor of Lactobacillus leichmannii ribonucleoside triphosphate reductase: evidence for thiyl radical-mediated nucleotide radical formation. Biochemistry. 37: 5528-35. PMID 9548936 DOI: 10.1021/Bi972934E  0.384
1998 Stubbe J. Ribonucleotide reductases in the twenty-first century Proceedings of the National Academy of Sciences of the United States of America. 95: 2723-2724. PMID 9501154 DOI: 10.1073/Pnas.95.6.2723  0.306
1998 Burdi D, Willems J, Riggs-Gelasco P, Antholine WE, Stubbe J, Hoffman BM. The Core Structure of X Generated in the Assembly of the Diiron Cluster of Ribonucleotide Reductase: 17O2and H217O ENDOR Journal of the American Chemical Society. 120: 12910-12919. DOI: 10.1021/Ja9824270  0.745
1998 Boger DL, Ramsey TM, Cai H, Hoehn ST, Stubbe J. A Systematic Evaluation of the Bleomycin A2l-Threonine Side Chain:  Its Role in Preorganization of a Compact Conformation Implicated in Sequence-Selective DNA Cleavage Journal of the American Chemical Society. 120: 9139-9148. DOI: 10.1021/Ja9816638  0.304
1998 van der Donk WA, Gerfen GJ, Stubbe J. Direct EPR Spectroscopic Evidence for an Allylic Radical Generated from (E)-2‘-Fluoromethylene-2‘-deoxycytidine 5‘-Diphosphate byE.coliRibonucleotide Reductase Journal of the American Chemical Society. 120: 4252-4253. DOI: 10.1021/Ja9740273  0.348
1998 Wu W, Vanderwall DE, Teramoto S, Lui SM, Hoehn ST, Tang XJ, Turner CJ, Boger DL, Kozarich JW, Stubbe J. NMR studies of Co·deglycobleomycin A2 green and its complex with d(CCAGGCCTGG) Journal of the American Chemical Society. 120: 2239-2250. DOI: 10.1021/Ja972125I  0.321
1998 Riggs-Gelasco PJ, Shu L, Chen S, Burdi D, Huynh BH, Que L, Stubbe J. EXAFS Characterization of the Intermediate X Generated During the Assembly of the Escherichia coli Ribonucleotide Reductase R2 Diferric Tyrosyl Radical Cofactor Journal of the American Chemical Society. 120: 849-860. DOI: 10.1021/Ja9718230  0.753
1997 Vanderwall DE, Lui SM, Wu W, Turner CJ, Kozarich JW, Stubbe J. A model of the structure of HOO-Co.bleomycin bound to d(CCAGTACTGG): recognition at the d(GpT) site and implications for double-stranded DNA cleavage. Chemistry & Biology. 4: 373-87. PMID 9195876 DOI: 10.1016/S1074-5521(97)90128-9  0.302
1997 Burdi D, Aveline BM, Wood PD, Stubbe J, Redmond RW. Generation of a tryptophan radical in high quantum yield from a novel amino acid analog using near-UV/visible light Journal of the American Chemical Society. 119: 6457-6460. DOI: 10.1021/Ja9706918  0.398
1997 Lui SM, Vanderwall DE, Wu W, Tang XJ, Turner CJ, Kozarich JW, Stubbe J. Structural characterization of Co·Bleomycin A2 brown: Free and bound to d(CCAGGCCTGG) Journal of the American Chemical Society. 119: 9603-9613. DOI: 10.1021/Ja963889L  0.326
1997 Ashley GW, Lawrence CC, Stubbe J, Robins MJ. Mechanism based inactivation of the adenosylcobalamin-dependent ribonucleotide reductase from L. leichmannii by 2'-ara-2'-azido-2'-deoxy adenosine-5'-triphosphate: Observation of paramagnetic intermediates Tetrahedron. 53: 12005-12016. DOI: 10.1016/S0040-4020(97)00713-8  0.335
1996 van der Donk WA, Zeng C, Biemann K, Stubbe J, Hanlon A, Kyte J. Identification of an active site residue of the R1 subunit of ribonucleotide reductase from Escherichia coli: characterization of substrate-induced polypeptide cleavage by C225SR1. Biochemistry. 35: 10058-67. PMID 8756468 DOI: 10.1021/Bi952869D  0.537
1996 van der Donk WA, Yu G, Silva DJ, Stubbe J, McCarthy JR, Jarvi ET, Matthews DP, Resvick RJ, Wagner E. Inactivation of ribonucleotide reductase by (E)-2'-fluoromethylene-2'-deoxycytidine 5'-diphosphate: a paradigm for nucleotide mechanism-based inhibitors. Biochemistry. 35: 8381-91. PMID 8679596 DOI: 10.1021/Bi960190J  0.586
1996 Licht S, Gerfen GJ, Stubbe J. Thiyl radicals in ribonucleotide reductases. Science (New York, N.Y.). 271: 477-81. PMID 8560260 DOI: 10.1126/Science.271.5248.477  0.608
1996 Wodzinska J, Snell KD, Rhomberg A, Sinskey AJ, Biemann K, Stubbe J. Polyhydroxybutyrate synthase: Evidence for covalent catalysis Journal of the American Chemical Society. 118: 6319-6320. DOI: 10.1021/Ja961108A  0.306
1996 Gerfen GJ, Licht S, Willems JP, Hoffman BM, Stubbe J. Electron paramagnetic resonance investigations of a kinetically competent intermediate formed in ribonucleotide reduction: Evidence for a thiyl radical-cob(II)alamin interaction Journal of the American Chemical Society. 118: 8192-8197. DOI: 10.1021/Ja960363S  0.577
1996 Tong WH, Chen S, Lloyd SG, Edmondson DE, Huynh BH, Stubbe J. Mechanism of Assembly of the Diferric Cluster−Tyrosyl Radical Cofactor of Escherichia coli Ribonucleotide Reductase from the Diferrous Form of the R2 Subunit Journal of the American Chemical Society. 118: 2107-2108. DOI: 10.1021/Ja952764Y  0.403
1996 Burdi D, Sturgeon BE, Tong WH, Stubbe J, Hoffman BM. Rapid Freeze−Quench ENDOR of the Radical X Intermediate ofEscherichia coliRibonucleotide Reductase Using17O2, H217O, and2H2O Journal of the American Chemical Society. 118: 281-282. DOI: 10.1021/Ja952651E  0.341
1996 Wu W, Vanderwall DE, Turner CJ, Kozarich JW, Stubbe J. Solution structure of Co·Bleomycin A2 green complexed with d(CCAGGCCTGG) Journal of the American Chemical Society. 118: 1281-1294. DOI: 10.1021/Ja952497W  0.325
1996 Wu W, Vanderwall DE, Lui SM, Tang XJ, Turner CJ, Kozarich JW, Stubbe J. Studies of Co·Bleomycin A2 green: Its detailed structural characterization by NMR and molecular modeling and its sequence-specific interaction with DNA oligonucleotides Journal of the American Chemical Society. 118: 1268-1280. DOI: 10.1021/Ja9524964  0.306
1995 Stubbe J, van der Donk WA. Ribonucleotide reductases: radical enzymes with suicidal tendencies. Chemistry & Biology. 2: 793-801. PMID 8807812  0.513
1995 Bollinger JM, Tong WH, Ravi N, Huynh BH, Edmondson DE, Stubbe JA. Use of rapid kinetics methods to study the assembly of the diferric-tyrosyl radical cofactor of E. coli ribonucleotide reductase. Methods in Enzymology. 258: 278-303. PMID 8524156 DOI: 10.1016/0076-6879(95)58052-2  0.665
1995 Rudolph J, Stubbe J. Investigation of the mechanism of phosphoribosylamine transfer from glutamine phosphoribosylpyrophosphate amidotransferase to glycinamide ribonucleotide synthetase. Biochemistry. 34: 2241-2250. PMID 7532005 DOI: 10.1021/Bi00007A019  0.369
1995 Absalon MJ, Wu W, Kozarich JW, Stubbe J. Sequence-Specific Double-Strand Cleavage of DNA by Fe-Bleomycin. 2. Mechanism and Dynamics Biochemistry. 34: 2076-2086. PMID 7531499 DOI: 10.1021/Bi00006A030  0.355
1995 Absalon MJ, Kozarich JW, Stubbe J. Sequence-specific double-strand cleavage of DNA by Fe-bleomycin. 1. The detection of sequence-specific double-strand breaks using hairpin oligonucleotides. Biochemistry. 34: 2065-2075. PMID 7531498 DOI: 10.1021/Bi00006A029  0.324
1995 Pulver SC, Tong WH, Bollinger JM, Stubbe J, Solomon EI. Circular dichroism and magnetic circular dichroism studies of the fully reduced binuclear non-heme iron active site in the Escherichia coli R2 subunit of ribonucleoside diphosphate reductase Journal of the American Chemical Society. 117: 12664-12678. DOI: 10.1021/Ja00156A002  0.706
1995 Lai M, Wu W, Stubbe J. Characterization of a Novel, Stable Norcaradiene Adduct Resulting from the Inactivation of Thymine Hydroxylase by 5-Ethynyluracil Journal of the American Chemical Society. 117: 5023-5030. DOI: 10.1021/Ja00123A003  0.311
1994 Gerngross TU, Snell KD, Peoples OP, Sinskey AJ, Csuhai E, Masamune S, Stubbe J. Overexpression and purification of the soluble polyhydroxyalkanoate synthase from Alcaligenes eutrophus: evidence for a required posttranslational modification for catalytic activity. Biochemistry. 33: 9311-20. PMID 8049232 DOI: 10.1021/Bi00197A035  0.738
1994 Booker S, Licht S, Broderick J, Stubbe J. Coenzyme B12-dependent ribonucleotide reductase: evidence for the participation of five cysteine residues in ribonucleotide reduction. Biochemistry. 33: 12676-85. PMID 7918494 DOI: 10.1021/Bi00208A019  0.792
1994 Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ. Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms. Biochemistry. 33: 11927-34. PMID 7918411 DOI: 10.1021/Bi00205A031  0.335
1994 Bollinger JM, Tong WH, Ravi N, Huynh BH, Edmondson DE, Stubbe J. Mechanism of Assembly of the Tyrosyl Radical-Diiron(III) Cofactorof E. coli Ribonucleotide Reductase. 3. Kinetics of the Limiting Fe2+ Reaction by Optical, EPR, and Moessbauer Spectroscopies Journal of the American Chemical Society. 116: 8024-8032. DOI: 10.1021/Ja00097A009  0.698
1994 Ravi N, Bollinger JM, Huynh BH, Stubbe J, Edmondson DE. Mechanism of Assembly of the Tyrosyl Radical-Diiron(III) Cofactor of E. Coli Ribonucleotide Reductase: 1. Moessbauer Characterization of the Diferric Radical Precursor Journal of the American Chemical Society. 116: 8007-8014. DOI: 10.1021/Ja00097A007  0.714
1993 Booker S, Stubbe J. Cloning, sequencing, and expression of the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii Proceedings of the National Academy of Sciences of the United States of America. 90: 8352-8356. PMID 8397403 DOI: 10.1073/Pnas.90.18.8352  0.627
1993 Gerngross TU, Reilly P, Stubbe J, Sinskey AJ, Peoples OP. Immunocytochemical analysis of poly-beta-hydroxybutyrate (PHB) synthase in Alcaligenes eutrophus H16: localization of the synthase enzyme at the surface of PHB granules. Journal of Bacteriology. 175: 5289-93. PMID 8349571 DOI: 10.1128/Jb.175.16.5289-5293.1993  0.697
1993 Thornburg LD, Stubbe J. Mechanism-based inactivation of thymine hydroxylase, an α-ketoglutarate- dependent dioxygenase, by 5-ethynyluracil Biochemistry. 32: 14034-14042. PMID 8268182 DOI: 10.1021/Bi00213A037  0.351
1993 Thornburg LD, Lai MT, Wishnok JS, Stubbe J. A non-heme iron protein with heme tendencies: An investigation of the substrate specificity of thymine hydroxylase Biochemistry. 32: 14023-14033. PMID 8268181 DOI: 10.1021/Bi00213A036  0.39
1993 Salowe S, Bollinger JM, Ator M, Stubbe J, McCraken J, Peisach J, Samano MC, Robins MJ. Alternative model for mechanism-based inhibition of Escherichia coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine 5'-diphosphate. Biochemistry. 32: 12749-60. PMID 8251496 DOI: 10.1021/Bi00210A026  0.732
1993 Booker S, Broderick J, Stubbe J. Ribonucleotide reductases: Radical enzymes with suicidal tendencies Biochemical Society Transactions. 21: 727-730. PMID 8224499 DOI: 10.1042/Bst0210727  0.742
1993 Worth L, Frank BL, Christner DF, Absalon MJ, Stubbe J, Kozarich JW. Isotope effects on the cleavage of DNA by bleomycin: mechanism and modulation. Biochemistry. 32: 2601-2609. PMID 7680571 DOI: 10.1021/Bi00061A018  0.317
1993 Gerfen GJ, Bellew BF, Un S, Bollinger JM, Stubbe J, Griffin RG, Singel DJ. High-frequency (139.5 GHz) EPR spectroscopy of the tyrosyl radical in Escherichia coli ribonucleotide reductase Journal of the American Chemical Society. 115: 6420-6421. DOI: 10.1021/Ja00067A071  0.682
1993 Ravi N, Bollinger J, Tong W, Edmondson D, Stubbe J, Huynh B. A Mössbauer investigation of the kinetic intermediates involved in formation of the tyrosyl radical-diferric center cofactor in E. Coli ribonucleotide reductase Journal of Inorganic Biochemistry. 51: 276. DOI: 10.1016/0162-0134(93)85308-U  0.712
1993 Bollinger J, Ravi N, Tong W, Edmondson D, Huynh B, Stubbe J. Assembly of the iron center-tyrosyl radical cofactor of ribonucleotide reductase Journal of Inorganic Biochemistry. 51: 6. DOI: 10.1016/0162-0134(93)85045-A  0.684
1992 Mao SS, Yu GX, Chalfoun D, Stubbe J. Characterization of C439SR1, a mutant of Escherichia coli ribonucleotide diphosphate reductase: evidence that C439 is a residue essential for nucleotide reduction and C439SR1 is a protein possessing novel thioredoxin-like activity. Biochemistry. 31: 9752-9759. PMID 1390751 DOI: 10.1021/Bi00155A031  0.38
1992 Absalon MJ, Krishnamoorthy CR, McGall G, Kozarich JW, Stubbe J. Bleomycin mediated degradation of DNA-RNA hybrids does not involve C–1′ chemistry Nucleic Acids Research. 20: 4179-4185. PMID 1380696 DOI: 10.1093/Nar/20.16.4179  0.309
1992 Christner DF, Frank BL, Kozarich JW, Stubbe J, Golik J, Doyle TW, Rosenberg IE, Krishnan B. Unmasking the chemistry of DNA cleavage by the esperamicins : modulation of 4'-hydrogen abstraction and bistranded damage by the fucose-anthranilate moiety Journal of the American Chemical Society. 114: 8763-8767. DOI: 10.1021/Ja00049A002  0.302
1991 Baker CH, Banzon J, Bollinger JM, Stubbe J, Samano V, Robins MJ, Lippert B, Jarvi E, Resvick R. 2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase. Journal of Medicinal Chemistry. 34: 1879-84. PMID 2061926 DOI: 10.1021/Jm00110A019  0.706
1991 Kappen LS, Goldberg IH, Frank BL, Worth L, Christner DF, Kozarich JW, Stubbe J. Neocarzinostatin-induced hydrogen atom abstraction from C-4' and C-5' of the T residue at a d(GT) step in oligonucleotides: shuttling between deoxyribose attack sites based on isotope selection effects. Biochemistry. 30: 2034-2042. PMID 1825606 DOI: 10.1021/Bi00222A005  0.301
1991 Bollinger JM, Edmondson DE, Huynh BH, Filley J, Norton JR, Stubbe J. Mechanism of assembly of the tyrosyl radical-dinuclear iron cluster cofactor of ribonucleotide reductase. Science (New York, N.Y.). 253: 292-8. PMID 1650033 DOI: 10.1126/Science.1650033  0.714
1991 Bollinger JM, Stubbe J, Huynh BH, Edmondson DE. Novel diferric radical intermediate responsible for tyrosyl radical formation in assembly of the cofactor of ribonucleotide reductase Journal of the American Chemical Society. 113: 6289-6291. DOI: 10.1021/Ja00016A066  0.7
1991 Stubbe J. Dinuclear non-heme iron centers: structure and function Current Opinion in Structural Biology. 1: 788-795. DOI: 10.1016/0959-440X(91)90180-2  0.327
1991 Bollinger T, Edmondson D, Huynh B, Filley J, Norton J, Stubbe J. Mechanism of assembly of the tyrosyl radical-diferric cluster cofactor of E. coli ribonucleotide reductase. Journal of Inorganic Biochemistry. 43: 524. DOI: 10.1016/0162-0134(91)84499-Y  0.319
1989 Ashley GW, Harris G, Stubbe JA. Inactivation of the ribonucleoside triphosphate reductase from Lactobacillus leichmannii by 2'-chloro-2'-deoxyuridine 5'-triphosphate: a 3'-2' hydrogen transfer during the formation of 3'-keto-2'-deoxyuridine 5'-triphosphate. Biochemistry. 27: 7841-5. PMID 3061462 DOI: 10.1021/Bi00420A038  0.357
1989 Mao SS, Johnston MI, Bollinger JM, Stubbe J. Mechanism-based inhibition of a mutant Escherichia coli ribonucleotide reductase (cysteine-225----serine) by its substrate CDP. Proceedings of the National Academy of Sciences of the United States of America. 86: 1485-9. PMID 2493643 DOI: 10.1073/Pnas.86.5.1485  0.694
1989 Bender CJ, Sahlin M, Babcock GT, Barry BA, Chandrashekar TK, Salowe SP, Stubbe J, Lindstroem B, Petersson L. An ENDOR study of the tyrosyl free radical in ribonucleotide reductase from Escherichia coli Journal of the American Chemical Society. 111: 8076-8083. DOI: 10.1021/Ja00203A002  0.393
1989 Cole R, Frey P, Stubbe J, Sigman D. Abstracts, division of biological chemistry, 199th national meeting of the American chemical society, April 22-27, 1990 Biochemistry. 28: 2181-2204. DOI: 10.1021/Bi00430A600  0.453
1988 Ashley GW, Harris G, Stubbe J. Inactivation of the Lactobacillus leichmannii ribonucleoside triphosphate reductase by 2'-chloro-2'-deoxyuridine 5'-triphosphate: stoichiometry of inactivation, site of inactivation, and mechanism of the protein chromophore formation. Biochemistry. 27: 4305-10. PMID 3048383 DOI: 10.1021/Bi00412A017  0.379
1988 Stubbe J. Radicals in biological catalysis Biochemistry. 27: 3893-3900. PMID 3046660 DOI: 10.1021/Bi00411A001  0.338
1987 Lin ANI, Ashley GW, Stubbe J. Location of the redox-active thiols of ribonucleotide reductase: sequence similarity between the Escherichia coli and Lactobacillus leichmannii enzymes. Biochemistry. 26: 6905-6909. PMID 3322391 DOI: 10.1021/Bi00396A006  0.322
1987 Salowe SP, Ator MA, Stubbe J. Products of the inactivation of ribonucleoside diphosphate reductase from Escherichia coli with 2'-azido-2'-deoxyuridine 5'-diphosphate. Biochemistry. 26: 3408-3416. PMID 3307907 DOI: 10.1021/Bi00386A024  0.315
1987 Harris G, Ashley GW, Robins MJ, Tolman RL, Stubbe J. 2'-Deoxy-2'-halonucleotides as alternate substrates and mechanism-based inactivators of Lactobacillus leichmannii ribonucleotide reductase. Biochemistry. 26: 1895-902. PMID 3297135 DOI: 10.1021/Bi00381A017  0.358
1986 Ajmera S, Wu JC, Worth L, Rabow LE, Stubbe J, Kozarich JW. DNA degradation by bleomycin: evidence for 2'R-proton abstraction and for C-O bond cleavage accompanying base propenal formation. Biochemistry. 25: 6586-6592. PMID 2431710 DOI: 10.1021/Bi00369A037  0.369
1986 Wu JC, Stubbe J, Kozarich JW. Mechanism of bleomycin: evidence for 4'-ketone formation in poly(dA-dU) associated exclusively with free base release. Biochemistry. 24: 7569-73. PMID 2418869 DOI: 10.1021/Bi00347A010  0.321
1986 Wu JC, Kozarich JW, Stubbe J. Mechanism of bleomycin: evidence for a rate-determining 4'-hydrogen abstraction from poly(dA-dU) associated with the formation of both free base and base propenal. Biochemistry. 24: 7562-8. PMID 2418868 DOI: 10.1021/Bi00347A009  0.313
1985 Ator MA, Stubbe J. Mechanism of inactivation of Escherichia coli ribonucleotide reductase by 2'-chloro-2'-deoxyuridine 5'-diphosphate: evidence for generation of a 2'-deoxy-3'-ketonucleotide via a net 1,2 hydrogen shift. Biochemistry. 24: 7214-7221. PMID 3910098 DOI: 10.1021/Bi00346A029  0.35
1980 Stubbe J, Abeles RH. Mechanism of action of enolase: effect of the beta-hydroxy group on the rate of dissociation of the alpha-carbon-hydrogen bond. Biochemistry. 19: 5505-12. PMID 7006686 DOI: 10.1021/Bi00565A007  0.54
1972 Stubbe JA, Kenyon GL. Analogs of phosphoenolpyruvate. Substrate specificities of enolase and pyruvate kinase from rabbit muscle. Biochemistry. 11: 338-45. PMID 5062057 DOI: 10.1021/Bi00753A005  0.435
1971 Stubbe JA, Kenyon GL. Analogs of phosphoenolpyruvate. On the specificity of pyruvate kinase from rabbit muscle. Biochemistry. 10: 2669-77. PMID 5105182 DOI: 10.1021/Bi00790A003  0.416
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