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JoAnne Stubbe - Publications

Affiliations: 
Chemistry Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
biological chemistry
Website:
http://www.mit.edu/~chemistry/faculty/stubbe.html
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Year Citation  Score
2023 Zhu Q, Costentin C, Stubbe J, Nocera DG. Disulfide radical anion as a super-reductant in biology and photoredox chemistry. Chemical Science. 14: 6876-6881. PMID 37389245 DOI: 10.1039/d3sc01867a  0.497
2023 Cui C, Song DY, Drennan CL, Stubbe J, Nocera DG. Radical Transport Facilitated by a Proton Transfer Network at the Subunit Interface of Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 36812162 DOI: 10.1021/jacs.2c11483  0.462
2022 Meyer A, Kehl A, Cui C, Reichardt FAK, Hecker F, Funk LM, Ghosh MK, Pan KT, Urlaub H, Tittmann K, Stubbe J, Bennati M. F Electron-Nuclear Double Resonance Reveals Interaction between Redox-Active Tyrosines across the α/β Interface of Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 35652913 DOI: 10.1021/jacs.2c02906  0.791
2021 Stubbe J, Nocera DG. Radicals in Biology: Your Life Is in Their Hands. Journal of the American Chemical Society. 143: 13463-13472. PMID 34423635 DOI: 10.1021/jacs.1c05952  0.459
2020 Cui C, Greene BL, Kang G, Drennan CL, Stubbe J, Nocera DG. Gated Proton Release during Radical Transfer at the Subunit Interface of Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 33353307 DOI: 10.1021/jacs.0c07879  0.72
2020 Reinhardt CR, Li P, Kang G, Stubbe J, Drennan CL, Hammes-Schiffer S. Conformational Motions and Water Networks at the α/β Interface in E. coli Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 32631052 DOI: 10.1021/Jacs.0C04325  0.345
2020 Greene BL, Kang G, Cui C, Bennati M, Nocera DG, Drennan CL, Stubbe J. Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets. Annual Review of Biochemistry. 89: 45-75. PMID 32569524 DOI: 10.1146/Annurev-Biochem-013118-111843  0.72
2020 Kang G, Taguchi AT, Stubbe J, Drennan CL. Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex. Science (New York, N.Y.). PMID 32217749 DOI: 10.1126/Science.Aba6794  0.403
2020 Ravichandran KR, Olshansky L, Nocera DG, Stubbe J. Subunit Interaction Dynamics of Class Ia Ribonucleotide Reductases: In Search of a Robust Assay. Biochemistry. PMID 32186371 DOI: 10.1021/Acs.Biochem.0C00001  0.552
2019 Greene BL, Stubbe J, Nocera DG. Selenocysteine Substitution into a Class I Ribonucleotide Reductase. Biochemistry. PMID 31774661 DOI: 10.1021/Acs.Biochem.9B00973  0.759
2019 Thomas WC, Brooks FP, Burnim AA, Bacik JP, Stubbe J, Kaelber JT, Chen JZ, Ando N. Convergent allostery in ribonucleotide reductase. Nature Communications. 10: 2653. PMID 31201319 DOI: 10.1038/S41467-019-10568-4  0.354
2018 Stubbe J, Seyedsayamdost MR. Discovery of a New Class I Ribonucleotide Reductase with an Essential DOPA Radical and NO Metal as an Initiator of Long-Range Radical Transfer. Biochemistry. PMID 30586288 DOI: 10.1021/Acs.Biochem.8B01238  0.565
2018 Greene BL, Stubbe J, Nocera DG. Photochemical Rescue of a Conformationally Inactivated Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 30347141 DOI: 10.1021/Jacs.8B07902  0.737
2018 Greene BL, Nocera DG, Stubbe J. Basis of dATP inhibition of RNRs. The Journal of Biological Chemistry. 293: 10413-10414. PMID 29959279 DOI: 10.1074/Jbc.H118.003717  0.715
2018 Lee W, Kasanmascheff M, Huynh M, Quartararo A, Costentin C, Bejenke I, Nocera DG, Bennati M, Tommos C, Stubbe J. Properties of Site-Specifically Incorporated 3-Aminotyrosine in Proteins To Study Redox-Active Tyrosines: Escherichia coli Ribonucleotide Reductase as a Paradigm. Biochemistry. PMID 29630358 DOI: 10.1021/Acs.Biochem.8B00160  0.534
2018 Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F. 3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife. 7. PMID 29460780 DOI: 10.7554/Elife.31502  0.633
2017 Greene BL, Taguchi AT, Stubbe J, Nocera DG. Conformationally-Dynamic Radical Transfer within Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 29037038 DOI: 10.1021/Jacs.7B08192  0.752
2017 Nick TU, Ravichandran KR, Stubbe J, Kasanmascheff M, Bennati M. Spectroscopic Evidence for a H Bond Network at Y356 Located at the Subunit Interface of Active E. coli Ribonucleotide Reductase. Biochemistry. PMID 28640584 DOI: 10.1021/Acs.Biochem.7B00462  0.353
2017 Li H, Stümpfig M, Zhang C, An X, Stubbe J, Lill R, Huang M. The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements. The Journal of Biological Chemistry. PMID 28515324 DOI: 10.1074/Jbc.M117.786178  0.334
2017 Lin Q, Parker MJ, Taguchi AT, Ravichandran K, Kim A, Kang G, Shao J, Drennan CL, Stubbe J. Glutamate 52-β at the α/β Subunit Interface of E. coli Class Ia Ribonucleotide Reductase is essential for Conformational Gating of Radical Transfer. The Journal of Biological Chemistry. PMID 28377505 DOI: 10.1074/Jbc.M117.783092  0.374
2017 Ravichandran KR, Zong AB, Taguchi AT, Nocera DG, Stubbe J, Tommos C. Formal reduction potentials of difluorotyrosine and trifluorotyrosine protein residues: Defining the thermodynamics of multistep radical transfer. Journal of the American Chemical Society. PMID 28171730 DOI: 10.1021/Jacs.6B11011  0.482
2017 Ravichandran KR, Minnihan EC, Lin Q, Yokoyama K, Taguchi AT, Shao J, Nocera DG, Stubbe J. Glutamate 350 plays an essential role in conformational gating of long range radical transport in E. coli class Ia ribonucleotide reductase. Biochemistry. PMID 28103007 DOI: 10.1021/Acs.Biochem.6B01145  0.491
2016 Kasanmascheff M, Lee W, Nick TU, Stubbe J, Bennati M. Radical transfer in ribonucleotide reductase: a NHY/RA-α mutant unmasks a new conformation of the pathway residue 731. Chemical Science. 7: 2170-2178. PMID 29899944 DOI: 10.1039/C5Sc03460D  0.378
2016 Ravichandran KR, Taguchi AT, Wei Y, Tommos C, Nocera DG, Stubbe J. A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes. Journal of the American Chemical Society. 138: 13706-13716. PMID 28068088 DOI: 10.1021/Jacs.6B08200  0.544
2016 Wittenborn EC, Jost M, Wei Y, Stubbe J, Drennan CL. Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator. The Journal of Biological Chemistry. PMID 27742839 DOI: 10.1074/Jbc.M116.756833  0.364
2016 Ravichandran KR, Taguchi AT, Wei Y, Tommos C, Nocera DG, Stubbe J. A >200 meV uphill thermodynamic landscape for radical transport in E. coli ribonucleotide reductase determined using fluorotyrosine-substituted enzymes. Journal of the American Chemical Society. PMID 27649294 DOI: 10.1021/jacs.6b08200  0.482
2016 Oyala PH, Ravichandran KR, Funk MA, Stucky PA, Stich TA, Drennan CL, Britt RD, Stubbe J. Biophysical characterization of fluorotyrosine probes site-specifically incorporated into enzymes: E. coli ribonucleotide reductase as an example. Journal of the American Chemical Society. PMID 27276098 DOI: 10.1021/Jacs.6B03605  0.623
2016 Olshansky L, Greene BL, Finkbeiner C, Stubbe J, Nocera DG. Photochemical Generation of a Tryptophan Radical within the Subunit Interface of Ribonucleotide Reductase. Biochemistry. PMID 27159163 DOI: 10.1021/Acs.Biochem.6B00292  0.739
2016 Ando N, Li H, Brignole EJ, Thompson S, McLaughlin MI, Page JE, Asturias FJ, Stubbe J, Drennan CL. Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer. Biochemistry. PMID 26727048 DOI: 10.1021/Acs.Biochem.5B01207  0.341
2015 Olshansky L, Stubbe J, Nocera DG. Charge Transfer Dynamics at the α/β Subunit Interface of a Photo-chemical Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 26710997 DOI: 10.1021/Jacs.5B09259  0.533
2015 Song DY, Pizano AA, Holder PG, Stubbe J, Nocera DG. Direct Interfacial Y731 Oxidation in α2 by a Photoβ2 Subunit of E. coli Class Ia Ribonucleotide Reductase. Chemical Science (Royal Society of Chemistry : 2010). 6: 4519-4524. PMID 26504513 DOI: 10.1039/C5Sc01125F  0.553
2015 Ravichandran KR, Minnihan EC, Wei Y, Nocera DG, Stubbe J. Reverse electron transfer completes the catalytic cycle in a 2,3,5-trifluorotyrosine-substituted ribonucleotide reductase. Journal of the American Chemical Society. PMID 26492582 DOI: 10.1021/Jacs.5B09189  0.562
2015 Koo BJ, Huynh M, Halbach RL, Stubbe J, Nocera DG. Modulation of Phenol Oxidation in Cofacial Dyads. Journal of the American Chemical Society. 137: 11860-3. PMID 26305909 DOI: 10.1021/Jacs.5B05955  0.496
2015 Buckley RM, Stubbe J. Chemistry with an artificial primer of polyhydroxybutyrate synthase suggests a mechanism for chain termination. Biochemistry. 54: 2117-25. PMID 25741756 DOI: 10.1021/Bi501405B  0.341
2015 Nick TU, Lee W, Kossmann S, Neese F, Stubbe J, Bennati M. Hydrogen bond network between amino acid radical intermediates on the proton-coupled electron transfer pathway of E. coli α2 ribonucleotide reductase. Journal of the American Chemical Society. 137: 289-98. PMID 25516424 DOI: 10.1021/Ja510513Z  0.414
2015 Song DY, Pizano AA, Holder PG, Stubbe J, Nocera DG. Direct interfacial Y731 oxidation in α2 by a photoβ2 subunit of E. coli class Ia ribonucleotide reductase Chemical Science. 6: 4519-4524. DOI: 10.1039/c5sc01125f  0.438
2014 Olshansky L, Pizano AA, Wei Y, Stubbe J, Nocera DG. Kinetics of hydrogen atom abstraction from substrate by an active site thiyl radical in ribonucleotide reductase. Journal of the American Chemical Society. 136: 16210-6. PMID 25353063 DOI: 10.1021/Ja507313W  0.55
2014 Wei Y, Funk MA, Rosado LA, Baek J, Drennan CL, Stubbe J. The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant. Proceedings of the National Academy of Sciences of the United States of America. 111: E3756-65. PMID 25157154 DOI: 10.1073/Pnas.1414396111  0.596
2014 Wei Y, Mathies G, Yokoyama K, Chen J, Griffin RG, Stubbe J. A chemically competent thiosulfuranyl radical on the Escherichia coli class III ribonucleotide reductase. Journal of the American Chemical Society. 136: 9001-13. PMID 24827372 DOI: 10.1021/Ja5030194  0.428
2014 Zhang Y, Li H, Zhang C, An X, Liu L, Stubbe J, Huang M. Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proceedings of the National Academy of Sciences of the United States of America. 111: E1695-704. PMID 24733891 DOI: 10.1073/Pnas.1405204111  0.371
2014 Parker MJ, Zhu X, Stubbe J. Bacillus subtilis class Ib ribonucleotide reductase: high activity and dynamic subunit interactions. Biochemistry. 53: 766-76. PMID 24401092 DOI: 10.1021/Bi401056E  0.386
2013 Ravichandran KR, Liang L, Stubbe J, Tommos C. Formal reduction potential of 3,5-difluorotyrosine in a structured protein: insight into multistep radical transfer. Biochemistry. 52: 8907-15. PMID 24228716 DOI: 10.1021/Bi401494F  0.388
2013 Pizano AA, Olshansky L, Holder PG, Stubbe J, Nocera DG. Modulation of Y356 photooxidation in E. coli class Ia ribonucleotide reductase by Y731 across the α2:β2 interface. Journal of the American Chemical Society. 135: 13250-3. PMID 23927429 DOI: 10.1021/Ja405498E  0.571
2013 Minnihan EC, Nocera DG, Stubbe J. Reversible, long-range radical transfer in E. coli class Ia ribonucleotide reductase. Accounts of Chemical Research. 46: 2524-35. PMID 23730940 DOI: 10.1021/Ar4000407  0.607
2013 Wörsdörfer B, Conner DA, Yokoyama K, Livada J, Seyedsayamdost M, Jiang W, Silakov A, Stubbe J, Bollinger JM, Krebs C. Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer. Journal of the American Chemical Society. 135: 8585-93. PMID 23676140 DOI: 10.1021/Ja401342S  0.812
2013 Offenbacher AR, Minnihan EC, Stubbe J, Barry BA. Redox-linked changes to the hydrogen-bonding network of ribonucleotide reductase β2. Journal of the American Chemical Society. 135: 6380-3. PMID 23594029 DOI: 10.1021/Ja3032949  0.383
2013 Zhang Y, An X, Stubbe J, Huang M. Investigation of in vivo roles of the C-terminal tails of the small subunit (ββ') of Saccharomyces cerevisiae ribonucleotide reductase: contribution to cofactor formation and intersubunit association within the active holoenzyme. The Journal of Biological Chemistry. 288: 13951-9. PMID 23532842 DOI: 10.1074/Jbc.M113.467001  0.406
2013 Minnihan EC, Ando N, Brignole EJ, Olshansky L, Chittuluru J, Asturias FJ, Drennan CL, Nocera DG, Stubbe J. Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 110: 3835-40. PMID 23431160 DOI: 10.1073/Pnas.1220691110  0.599
2013 Cotruvo JA, Stich TA, Britt RD, Stubbe J. Mechanism of assembly of the dimanganese-tyrosyl radical cofactor of class Ib ribonucleotide reductase: enzymatic generation of superoxide is required for tyrosine oxidation via a Mn(III)Mn(IV) intermediate. Journal of the American Chemical Society. 135: 4027-39. PMID 23402532 DOI: 10.1021/Ja312457T  0.622
2012 Argirevi? T, Riplinger C, Stubbe J, Neese F, Bennati M. ENDOR spectroscopy and DFT calculations: evidence for the hydrogen-bond network within α2 in the PCET of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 134: 17661-70. PMID 23072506 DOI: 10.1021/Ja3071682  0.401
2012 Cotruvo JA, Stubbe J. Metallation and mismetallation of iron and manganese proteins in vitro and in vivo: the class I ribonucleotide reductases as a case study. Metallomics : Integrated Biometal Science. 4: 1020-36. PMID 22991063 DOI: 10.1039/C2Mt20142A  0.617
2012 Aye Y, Long MJ, Stubbe J. Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species. The Journal of Biological Chemistry. 287: 35768-78. PMID 22915594 DOI: 10.1074/Jbc.M112.396911  0.641
2012 Aye Y, Brignole EJ, Long MJ, Chittuluru J, Drennan CL, Asturias FJ, Stubbe J. Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers. Chemistry & Biology. 19: 799-805. PMID 22840768 DOI: 10.1016/J.Chembiol.2012.05.015  0.63
2012 Zimanyi CM, Ando N, Brignole EJ, Asturias FJ, Stubbe J, Drennan CL. Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase. Structure (London, England : 1993). 20: 1374-83. PMID 22727814 DOI: 10.1016/J.Str.2012.05.009  0.337
2012 Boal AK, Cotruvo JA, Stubbe J, Rosenzweig AC. The dimanganese(II) site of Bacillus subtilis class Ib ribonucleotide reductase. Biochemistry. 51: 3861-71. PMID 22443445 DOI: 10.1021/Bi201925T  0.632
2012 Cho M, Brigham CJ, Sinskey AJ, Stubbe J. Purification of polyhydroxybutyrate synthase from its native organism, Ralstonia eutropha: implications for the initiation and elongation of polymer formation in vivo. Biochemistry. 51: 2276-88. PMID 22369488 DOI: 10.1021/Bi2013596  0.343
2012 Pizano AA, Lutterman DA, Holder PG, Teets TS, Stubbe J, Nocera DG. Photo-ribonucleotide reductase β2 by selective cysteine labeling with a radical phototrigger. Proceedings of the National Academy of Sciences of the United States of America. 109: 39-43. PMID 22171005 DOI: 10.1073/Pnas.1115778108  0.556
2012 Holder PG, Pizano AA, Anderson BL, Stubbe J, Nocera DG. Deciphering radical transport in the large subunit of class I ribonucleotide reductase. Journal of the American Chemical Society. 134: 1172-80. PMID 22121977 DOI: 10.1021/Ja209016J  0.541
2011 Ando N, Brignole EJ, Zimanyi CM, Funk MA, Yokoyama K, Asturias FJ, Stubbe J, Drennan CL. Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 108: 21046-51. PMID 22160671 DOI: 10.1073/Pnas.1112715108  0.619
2011 Yokoyama K, Smith AA, Corzilius B, Griffin RG, Stubbe J. Equilibration of tyrosyl radicals (Y356•, Y731•, Y730•) in the radical propagation pathway of the Escherichia coli class Ia ribonucleotide reductase. Journal of the American Chemical Society. 133: 18420-32. PMID 21967342 DOI: 10.1021/Ja207455K  0.402
2011 Zhang Y, Liu L, Wu X, An X, Stubbe J, Huang M. Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins. The Journal of Biological Chemistry. 286: 41499-509. PMID 21931161 DOI: 10.1074/Jbc.M111.294074  0.329
2011 Minnihan EC, Young DD, Schultz PG, Stubbe J. Incorporation of fluorotyrosines into ribonucleotide reductase using an evolved, polyspecific aminoacyl-tRNA synthetase. Journal of the American Chemical Society. 133: 15942-5. PMID 21913683 DOI: 10.1021/Ja207719F  0.5
2011 Aye Y, Stubbe J. Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit. Proceedings of the National Academy of Sciences of the United States of America. 108: 9815-20. PMID 21628579 DOI: 10.1073/Pnas.1013274108  0.642
2011 Minnihan EC, Seyedsayamdost MR, Uhlin U, Stubbe J. Kinetics of radical intermediate formation and deoxynucleotide production in 3-aminotyrosine-substituted Escherichia coli ribonucleotide reductases. Journal of the American Chemical Society. 133: 9430-40. PMID 21612216 DOI: 10.1021/Ja201640N  0.673
2011 Zhang Y, Stubbe J. Bacillus subtilis class Ib ribonucleotide reductase is a dimanganese(III)-tyrosyl radical enzyme. Biochemistry. 50: 5615-23. PMID 21561096 DOI: 10.1021/Bi200348Q  0.384
2011 Stubbe J. Biochemistry. The two faces of SAM. Science (New York, N.Y.). 332: 544-5. PMID 21527702 DOI: 10.1126/Science.1204209  0.34
2011 Cotruvo JA, Stubbe J. Class I ribonucleotide reductases: metallocofactor assembly and repair in vitro and in vivo. Annual Review of Biochemistry. 80: 733-67. PMID 21456967 DOI: 10.1146/Annurev-Biochem-061408-095817  0.627
2011 Cotruvo JA, Stubbe J. Escherichia coli class Ib ribonucleotide reductase contains a dimanganese(III)-tyrosyl radical cofactor in vivo. Biochemistry. 50: 1672-81. PMID 21250660 DOI: 10.1021/Bi101881D  0.65
2011 Stubbe J, Cotruvo JA. Control of metallation and active cofactor assembly in the class Ia and Ib ribonucleotide reductases: diiron or dimanganese? Current Opinion in Chemical Biology. 15: 284-90. PMID 21216656 DOI: 10.1016/J.Cbpa.2010.12.001  0.64
2011 Seyedsayamdost MR, Yee CS, Stubbe J. Use of 2,3,5-F(3)Y-β2 and 3-NH(2)Y-α2 to study proton-coupled electron transfer in Escherichia coli ribonucleotide reductase. Biochemistry. 50: 1403-11. PMID 21182280 DOI: 10.1021/Bi101319V  0.651
2011 Holder PG, Nocera DG, Francis MB, Stubbe J. Guiding and measuring electron transfers in biomolecules: Lessons for photovoltaics, materials, and medicine Acs National Meeting Book of Abstracts.  0.357
2010 Yokoyama K, Uhlin U, Stubbe J. A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase. Journal of the American Chemical Society. 132: 15368-79. PMID 20929229 DOI: 10.1021/Ja1069344  0.438
2010 Boal AK, Cotruvo JA, Stubbe J, Rosenzweig AC. Structural basis for activation of class Ib ribonucleotide reductase. Science (New York, N.Y.). 329: 1526-30. PMID 20688982 DOI: 10.1126/Science.1190187  0.627
2010 Yokoyama K, Uhlin U, Stubbe J. Site-specific incorporation of 3-nitrotyrosine as a probe of pKa perturbation of redox-active tyrosines in ribonucleotide reductase. Journal of the American Chemical Society. 132: 8385-97. PMID 20518462 DOI: 10.1021/Ja101097P  0.4
2010 Lohman GJ, Stubbe J. Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: covalent modification. Biochemistry. 49: 1404-17. PMID 20088569 DOI: 10.1021/Bi902132U  0.305
2010 Lohman GJ, Gerfen GJ, Stubbe J. Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: adenosylcobalamin destruction and formation of a nucleotide-based radical. Biochemistry. 49: 1396-403. PMID 20088568 DOI: 10.1021/Bi9021318  0.375
2010 Cotruvo JA, Stubbe J. An active dimanganese(III)-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Biochemistry. 49: 1297-309. PMID 20070127 DOI: 10.1021/Bi902106N  0.656
2010 Sicoli G, Argirevi? T, Stubbe J, Tkach I, Bennati M. Effects in 94 GHz orientation-selected PELDOR on a rigid pair of radicals with Non-collinear axes Applied Magnetic Resonance. 37: 539-548. DOI: 10.1007/S00723-009-0094-3  0.357
2009 Minnihan EC, Seyedsayamdost MR, Stubbe J. Use of 3-aminotyrosine to examine the pathway dependence of radical propagation in Escherichia coli ribonucleotide reductase. Biochemistry. 48: 12125-32. PMID 19916558 DOI: 10.1021/Bi901439W  0.641
2009 Wang J, Lohman GJ, Stubbe J. Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5'-diphosphate. Biochemistry. 48: 11612-21. PMID 19899807 DOI: 10.1021/Bi901588Z  0.335
2009 Artin E, Wang J, Lohman GJ, Yokoyama K, Yu G, Griffin RG, Bar G, Stubbe J. Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant. Biochemistry. 48: 11622-9. PMID 19899770 DOI: 10.1021/Bi901590Q  0.402
2009 Seyedsayamdost MR, Argirevi? T, Minnihan EC, Stubbe J, Bennati M. Structural examination of the transient 3-aminotyrosyl radical on the PCET pathway of E. coli ribonucleotide reductase by multifrequency EPR spectroscopy. Journal of the American Chemical Society. 131: 15729-38. PMID 19821570 DOI: 10.1021/Ja903879W  0.668
2009 Li P, Chakraborty S, Stubbe J. Detection of covalent and noncovalent intermediates in the polymerization reaction catalyzed by a C149S class III polyhydroxybutyrate synthase. Biochemistry. 48: 9202-11. PMID 19711985 DOI: 10.1021/Bi901329B  0.351
2009 Seyedsayamdost MR, Stubbe J. Replacement of Y730 and Y731 in the alpha2 subunit of Escherichia coli ribonucleotide reductase with 3-aminotyrosine using an evolved suppressor tRNA/tRNA-synthetase pair. Methods in Enzymology. 462: 45-76. PMID 19632469 DOI: 10.1016/S0076-6879(09)62003-6  0.659
2009 Offenbacher AR, Vassiliev IR, Seyedsayamdost MR, Stubbe J, Barry BA. Redox-linked structural changes in ribonucleotide reductase. Journal of the American Chemical Society. 131: 7496-7. PMID 19489635 DOI: 10.1021/Ja901908J  0.637
2009 Reece SY, Lutterman DA, Seyedsayamdost MR, Stubbe J, Nocera DG. Re(bpy)(CO)3CN as a probe of conformational flexibility in a photochemical ribonucleotide reductase. Biochemistry. 48: 5832-8. PMID 19402704 DOI: 10.1021/Bi9005804  0.676
2008 Marletta MA, Stubbe J. Catalysis and regulation. Editorial overview. Current Opinion in Structural Biology. 18: 641-3. PMID 19059103 DOI: 10.1016/J.Sbi.2008.11.006  0.478
2008 Hassan AQ, Wang Y, Plate L, Stubbe J. Methodology to probe subunit interactions in ribonucleotide reductases. Biochemistry. 47: 13046-55. PMID 19012414 DOI: 10.1021/Bi8012559  0.303
2008 Cotruvo JA, Stubbe J. NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 105: 14383-8. PMID 18799738 DOI: 10.1073/Pnas.0807348105  0.646
2008 Morar M, Hoskins AA, Stubbe J, Ealick SE. Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation. Biochemistry. 47: 7816-30. PMID 18597481 DOI: 10.1021/Bi800329P  0.677
2008 Chen J, Ghorai MK, Kenney G, Stubbe J. Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage. Nucleic Acids Research. 36: 3781-90. PMID 18492718 DOI: 10.1093/Nar/Gkn302  0.608
2008 Hristova D, Wu CH, Jiang W, Krebs C, Stubbe J. Importance of the maintenance pathway in the regulation of the activity of Escherichia coli ribonucleotide reductase. Biochemistry. 47: 3989-99. PMID 18314964 DOI: 10.1021/Bi702408K  0.576
2008 Chen J, Dupradeau FY, Case DA, Turner CJ, Stubbe J. DNA oligonucleotides with A, T, G or C opposite an abasic site: structure and dynamics. Nucleic Acids Research. 36: 253-62. PMID 18025040 DOI: 10.1093/Nar/Gkm622  0.317
2007 Seyedsayamdost MR, Chan CT, Mugnaini V, Stubbe J, Bennati M. PELDOR spectroscopy with DOPA-beta2 and NH2Y-alpha2s: distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 129: 15748-9. PMID 18047343 DOI: 10.1021/Ja076459B  0.64
2007 Seyedsayamdost MR, Xie J, Chan CT, Schultz PG, Stubbe J. Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation. Journal of the American Chemical Society. 129: 15060-71. PMID 17990884 DOI: 10.1021/Ja076043Y  0.708
2007 Reece SY, Seyedsayamdost MR, Stubbe J, Nocera DG. Direct observation of a transient tyrosine radical competent for initiating turnover in a photochemical ribonucleotide reductase. Journal of the American Chemical Society. 129: 13828-30. PMID 17944464 DOI: 10.1021/Ja074452O  0.665
2007 Wu CH, Jiang W, Krebs C, Stubbe J. YfaE, a ferredoxin involved in diferric-tyrosyl radical maintenance in Escherichia coli ribonucleotide reductase. Biochemistry. 46: 11577-88. PMID 17880186 DOI: 10.1021/Bi7012454  0.577
2007 Wang J, Lohman GJ, Stubbe J. Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases. Proceedings of the National Academy of Sciences of the United States of America. 104: 14324-9. PMID 17726094 DOI: 10.1073/Pnas.0706803104  0.357
2007 Reece SY, Seyedsayamdost MR, Stubbe J, Nocera DG. Photoactive peptides for light-initiated tyrosyl radical generation and transport into ribonucleotide reductase. Journal of the American Chemical Society. 129: 8500-9. PMID 17567129 DOI: 10.1021/Ja0704434  0.695
2007 Seyedsayamdost MR, Yee CS, Stubbe J. Site-specific incorporation of fluorotyrosines into the R2 subunit of E. coli ribonucleotide reductase by expressed protein ligation. Nature Protocols. 2: 1225-35. PMID 17546018 DOI: 10.1038/Nprot.2007.159  0.585
2007 Chen J, Dupradeau FY, Case DA, Turner CJ, Stubbe J. Nuclear magnetic resonance structural studies and molecular modeling of duplex DNA containing normal and 4'-oxidized abasic sites. Biochemistry. 46: 3096-107. PMID 17323932 DOI: 10.1021/Bi6024269  0.342
2007 Hoskins AA, Morar M, Kappock TJ, Mathews II, Zaugg JB, Barder TE, Peng P, Okamoto A, Ealick SE, Stubbe J. N5-CAIR mutase: role of a CO2 binding site and substrate movement in catalysis. Biochemistry. 46: 2842-55. PMID 17298082 DOI: 10.1021/Bi602436G  0.688
2007 Seyedsayamdost MR, Stubbe J. Forward and reverse electron transfer with the Y356DOPA-beta2 heterodimer of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 129: 2226-7. PMID 17279757 DOI: 10.1021/Ja0685607  0.617
2006 Morar M, Anand R, Hoskins AA, Stubbe J, Ealick SE. Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily. Biochemistry. 45: 14880-95. PMID 17154526 DOI: 10.1021/Bi061591U  0.692
2006 Reece SY, Seyedsayamdost MR, Stubbe J, Nocera DG. Electron transfer reactions of fluorotyrosyl radicals. Journal of the American Chemical Society. 128: 13654-5. PMID 17044670 DOI: 10.1021/Ja0636688  0.641
2006 Ortigosa AD, Hristova D, Perlstein DL, Zhang Z, Huang M, Stubbe J. Determination of the in vivo stoichiometry of tyrosyl radical per betabeta' in Saccharomyces cerevisiae ribonucleotide reductase. Biochemistry. 45: 12282-94. PMID 17014081 DOI: 10.1021/Bi0610404  0.756
2006 Denysenkov VP, Prisner TF, Stubbe J, Bennati M. High-field pulsed electron-electron double resonance spectroscopy to determine the orientation of the tyrosyl radicals in ribonucleotide reductase Proceedings of the National Academy of Sciences of the United States of America. 103: 13386-13390. PMID 16938868 DOI: 10.1073/Pnas.0605851103  0.39
2006 Reece SY, Hodgkiss JM, Stubbe J, Nocera DG. Proton-coupled electron transfer: the mechanistic underpinning for radical transport and catalysis in biology. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 361: 1351-64. PMID 16873123 DOI: 10.1098/Rstb.2006.1874  0.551
2006 Seyedsayamdost MR, Stubbe J. Site-specific replacement of Y356 with 3,4-dihydroxyphenylalanine in the beta2 subunit of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 128: 2522-3. PMID 16492021 DOI: 10.1021/Ja057776Q  0.658
2006 Seyedsayamdost MR, Reece SY, Nocera DG, Stubbe J. Mono-, di-, tri-, and tetra-substituted fluorotyrosines: new probes for enzymes that use tyrosyl radicals in catalysis. Journal of the American Chemical Society. 128: 1569-79. PMID 16448128 DOI: 10.1021/Ja055926R  0.674
2006 Seyedsayamdost MR, Yee CS, Reece SY, Nocera DG, Stubbe J. pH Rate profiles of FnY356-R2s (n = 2, 3, 4) in Escherichia coli ribonucleotide reductase: evidence that Y356 is a redox-active amino acid along the radical propagation pathway. Journal of the American Chemical Society. 128: 1562-8. PMID 16448127 DOI: 10.1021/Ja055927J  0.7
2006 Zhang Z, An X, Yang K, Perlstein DL, Hicks L, Kelleher N, Stubbe J, Huang M. Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Proceedings of the National Academy of Sciences of the United States of America. 103: 1422-7. PMID 16432237 DOI: 10.1073/Pnas.0510516103  0.751
2005 Perlstein DL, Ge J, Ortigosa AD, Robblee JH, Zhang Z, Huang M, Stubbe J. The active form of the Saccharomyces cerevisiae ribonucleotide reductase small subunit is a heterodimer in vitro and in vivo. Biochemistry. 44: 15366-77. PMID 16285741 DOI: 10.1021/Bi051616+  0.735
2005 Bennati M, Robblee JH, Mugnaini V, Stubbe J, Freed JH, Borbat P. EPR distance measurements support a model for long-range radical initiation in E. coli ribonucleotide reductase. Journal of the American Chemical Society. 127: 15014-5. PMID 16248626 DOI: 10.1021/Ja054991Y  0.367
2005 Lawrence AG, Choi J, Rha C, Stubbe J, Sinskey AJ. In vitro analysis of the chain termination reaction in the synthesis of poly-(R)-beta-hydroxybutyrate by the class III synthase from Allochromatium vinosum. Biomacromolecules. 6: 2113-9. PMID 16004452 DOI: 10.1021/Bm0501048  0.372
2005 Tian J, Sinskey AJ, Stubbe J. Class III polyhydroxybutyrate synthase: Involvement in chain termination and reinitiation Biochemistry. 44: 8369-8377. PMID 15938626 DOI: 10.1021/Bi050331U  0.347
2005 Fritscher J, Artin E, Wnuk S, Bar G, Robblee JH, Kacprzak S, Kaupp M, Griffin RG, Bennati M, Stubbe J. Structure of the nitrogen-centered radical formed during inactivation of E. coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine-5'-diphosphate: trapping of the 3'-ketonucleotide. Journal of the American Chemical Society. 127: 7729-38. PMID 15913363 DOI: 10.1021/Ja043111X  0.364
2005 Tian J, He A, Lawrence AG, Liu P, Watson N, Sinskey AJ, Stubbe J. Analysis of transient polyhydroxybutyrate production in Wautersia eutropha H16 by quantitative Western analysis and transmission electron microscopy. Journal of Bacteriology. 187: 3825-32. PMID 15901707 DOI: 10.1128/Jb.187.11.3825-3832.2005  0.303
2005 Reece SY, Stubbe J, Nocera DG. pH Dependence of charge transfer between tryptophan and tyrosine in dipeptides. Biochimica Et Biophysica Acta. 1706: 232-8. PMID 15694351 DOI: 10.1016/J.Bbabio.2004.11.011  0.47
2005 Tian J, Sinskey AJ, Stubbe J. Detection of intermediates from the polymerization reaction catalyzed by a D302A mutant of class III polyhydroxyalkanoate (PHA) synthase Biochemistry. 44: 1495-1503. PMID 15683234 DOI: 10.1021/Bi047734Z  0.379
2005 Davydov R, Behrouzian B, Smoukov S, Stubbe J, Hoffman BM, Shanklin J. Effect of substrate on the diiron(III) site in stearoyl acyl carrier protein Δ9-desaturase as disclosed by cryoreduction electron paramagnetic resonance/electron nuclear double resonance spectroscopy Biochemistry. 44: 1309-1315. PMID 15667224 DOI: 10.1021/Bi048599T  0.374
2005 Denysenkov VP, Prisner TF, Stubbe J, Bennati M. High-frequency 180 GHz PELDOR Applied Magnetic Resonance. 29: 375-384. DOI: 10.1007/Bf03167024  0.307
2004 Chang MC, Yee CS, Nocera DG, Stubbe J. Site-specific replacement of a conserved tyrosine in ribonucleotide reductase with an aniline amino acid: a mechanistic probe for a redox-active tyrosine. Journal of the American Chemical Society. 126: 16702-3. PMID 15612690 DOI: 10.1021/Ja044124D  0.675
2004 Anand R, Hoskins AA, Bennett EM, Sintchak MD, Stubbe J, Ealick SE. A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex. Biochemistry. 43: 10343-52. PMID 15301532 DOI: 10.1021/Bi0491292  0.694
2004 Anand R, Hoskins AA, Stubbe J, Ealick SE. Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography. Biochemistry. 43: 10328-42. PMID 15301531 DOI: 10.1021/Bi0491301  0.677
2004 Hoskins AA, Anand R, Ealick SE, Stubbe J. The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation. Biochemistry. 43: 10314-27. PMID 15301530 DOI: 10.1021/Bi049127H  0.687
2004 Sommerhalter M, Voegtli WC, Perlstein DL, Ge J, Stubbe J, Rosenzweig AC. Structures of the yeast ribonucleotide reductase Rnr2 and Rnr4 homodimers. Biochemistry. 43: 7736-42. PMID 15196016 DOI: 10.1021/Bi049510M  0.747
2004 Chang MC, Yee CS, Stubbe J, Nocera DG. Turning on ribonucleotide reductase by light-initiated amino acid radical generation. Proceedings of the National Academy of Sciences of the United States of America. 101: 6882-7. PMID 15123822 DOI: 10.1073/Pnas.0401718101  0.689
2004 Chen J, Stubbe J. Synthesis and Characterization of Oligonucleotides Containing a 4′-Keto Abasic Site Biochemistry. 43: 5278-5286. PMID 15122893 DOI: 10.1021/Bi0495376  0.334
2003 Yee CS, Seyedsayamdost MR, Chang MC, Nocera DG, Stubbe J. Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process. Biochemistry. 42: 14541-52. PMID 14661967 DOI: 10.1021/Bi0352365  0.751
2003 Bennati M, Weber A, Antonic J, Perlstein DL, Robblee J, Stubbe J. Pulsed ELDOR Spectroscopy Measures the Distance between the Two Tyrosyl Radicals in the R2 Subunit of the E. coli Ribonucleotide Reductase Journal of the American Chemical Society. 125: 14988-14989. PMID 14653724 DOI: 10.1021/Ja0362095  0.751
2003 Yee CS, Chang MC, Ge J, Nocera DG, Stubbe J. 2,3-difluorotyrosine at position 356 of ribonucleotide reductase R2: a probe of long-range proton-coupled electron transfer. Journal of the American Chemical Society. 125: 10506-7. PMID 12940718 DOI: 10.1021/Ja036242R  0.67
2003 Ge J, Yu G, Ator MA, Stubbe J. Pre-steady-state and steady-state kinetic analysis of E. coli class I ribonucleotide reductase Biochemistry. 42: 10071-10083. PMID 12939135 DOI: 10.1021/Bi034374R  0.366
2003 Stubbe J, Nocera DG, Yee CS, Chang MC. Radical initiation in the class I ribonucleotide reductase: long-range proton-coupled electron transfer? Chemical Reviews. 103: 2167-201. PMID 12797828 DOI: 10.1021/Cr020421U  0.639
2003 Yao R, Zhang Z, An X, Bucci B, Perlstein DL, Stubbe J, Huang M. Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways Proceedings of the National Academy of Sciences of the United States of America. 100: 6628-6633. PMID 12732713 DOI: 10.1073/Pnas.1131932100  0.73
2003 Stubbe J. Di-iron-tyrosyl radical ribonucleotide reductases. Current Opinion in Chemical Biology. 7: 183-188. PMID 12714050 DOI: 10.1016/S1367-5931(03)00025-5  0.357
2003 Chen D, Abend A, Stubbe J, Frey PA. Epimerization at carbon-5' of (5'R)-[5'-2H]adenosylcobalamin by ribonucleoside triphosphate reductase: cysteine 408-independent cleavage of the Co-C5' bond. Biochemistry. 42: 4578-84. PMID 12693955 DOI: 10.1021/Bi030018X  0.558
2003 Stubbe J. Radicals with a controlled lifestyle Chemical Communications. 9: 2511-2513. DOI: 10.1039/B307617M  0.312
2002 Chang MC, Miller SE, Carpenter SD, Stubbe J, Nocera DG. Nanosecond generation of tyrosyl radicals via laser-initiated decaging of oxalate-modified amino acids. The Journal of Organic Chemistry. 67: 6820-2. PMID 12227817 DOI: 10.1021/Jo025569S  0.642
2002 Sintchak MD, Arjara G, Kellogg BA, Stubbe J, Drennan CL. The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer. Nature Structural Biology. 9: 293-300. PMID 11875520 DOI: 10.1038/Nsb774  0.329
2001 Yuan W, Jia Y, Tian J, Snell KD, Müh U, Sinskey AJ, Lambalot RH, Walsh CT, Stubbe J. Class I and III polyhydroxyalkanoate synthases from Ralstonia eutropha and Allochromatium vinosum: characterization and substrate specificity studies. Archives of Biochemistry and Biophysics. 394: 87-98. PMID 11566031 DOI: 10.1006/Abbi.2001.2522  0.513
2001 Voegtli WC, Ge J, Perlstein DL, Stubbe J, Rosenzweig AC. Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer. Proceedings of the National Academy of Sciences of the United States of America. 98: 10073-8. PMID 11526233 DOI: 10.1073/Pnas.181336398  0.772
2001 Ge J, Perlstein DL, Nguyen HH, Bar G, Griffin RG, Stubbe J. Why multiple small subunits (Y2 and Y4) for yeast ribonucleotide reductase? Toward understanding the role of Y4 Proceedings of the National Academy of Sciences of the United States of America. 98: 10067-10072. PMID 11526232 DOI: 10.1073/Pnas.181336498  0.76
2001 Hoehn ST, Turner CJ, Stubbe J. Solution structure of an oligonucleotide containing an abasic site: evidence for an unusual deoxyribose conformation. Nucleic Acids Research. 29: 3413-23. PMID 11504879 DOI: 10.1093/Nar/29.16.3413  0.314
2001 Bar G, Bennati M, Nguyen HH, Ge J, Stubbe JA, Griffin RG. High-frequency (140-GHz) time domain EPR and ENDOR spectroscopy: the tyrosyl radical-diiron cofactor in ribonucleotide reductase from yeast. Journal of the American Chemical Society. 123: 3569-76. PMID 11472128 DOI: 10.1021/Ja003108N  0.387
2001 Hoehn ST, Junker HD, Bunt RC, Turner CJ, Stubbe J. Solution structure of Co(III)-bleomycin-OOH bound to a phosphoglycolate lesion containing oligonucleotide: implications for bleomycin-induced double-strand DNA cleavage. Biochemistry. 40: 5894-905. PMID 11352724 DOI: 10.1021/Bi002635G  0.343
2001 Zilles JL, Kappock TJ, Stubbe J, Downs DM. Altered pathway routing in a class of Salmonella enterica serovar Typhimurium mutants defective in aminoimidazole ribonucleotide synthetase. Journal of Bacteriology. 183: 2234-40. PMID 11244062 DOI: 10.1128/Jb.183.7.2234-2240.2001  0.321
2001 Jia Y, Yuan W, Wodzinska J, Park C, Sinskey AJ, Stubbe J. Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism. Biochemistry. 40: 1011-9. PMID 11170423 DOI: 10.1021/Bi002219W  0.423
2001 Stubbe J, Ge J, Yee CS. The evolution of ribonucleotide reduction revisited Trends in Biochemical Sciences. 26: 93-99. PMID 11166566 DOI: 10.1016/S0968-0004(00)01764-3  0.373
2001 Bennati M, Stubbe J, Griffin RG. High-frequency EPR and ENDOR: Time-domain spectroscopy of ribonucleotide reductase Applied Magnetic Resonance. 21: 389-410. DOI: 10.1007/Bf03162416  0.338
2000 Stubbe J. Ribonucleotide reductases: the link between an RNA and a DNA world? Current Opinion in Structural Biology. 10: 731-736. PMID 11114511 DOI: 10.1016/S0959-440X(00)00153-6  0.331
2000 Harsch A, Marzilli LA, Bunt RC, Stubbe J, Vouros P. Accurate and rapid modeling of iron-bleomycin-induced DNA damage using tethered duplex oligonucleotides and electrospray ionization ion trap mass spectrometric analysis. Nucleic Acids Research. 28: 1978-85. PMID 10756200 DOI: 10.1093/Nar/28.9.1978  0.324
2000 Jia Y, Kappock TJ, Frick T, Sinskey AJ, Stubbe J. Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: characterization of the functional residues in Chromatium vinosum PHB synthase. Biochemistry. 39: 3927-36. PMID 10747780 DOI: 10.1021/Bi9928086  0.379
1999 Mathews II, Kappock TJ, Stubbe J, Ealick SE. Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway. Structure (London, England : 1993). 7: 1395-406. PMID 10574791 DOI: 10.1016/S0969-2126(00)80029-5  0.34
1999 Nguyen HHT, Ge J, Perlstein DL, Stubbe J. Purification of ribonucleotide reductase subunits Y1, Y2, Y3, and Y4 from yeast: Y4 plays a key role in diiron cluster assembly Proceedings of the National Academy of Sciences of the United States of America. 96: 12339-12344. PMID 10535923 DOI: 10.1073/Pnas.96.22.12339  0.757
1999 Li C, Kappock TJ, Stubbe J, Weaver TM, Ealick SE. X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution. Structure (London, England : 1993). 7: 1155-66. PMID 10508786 DOI: 10.1016/S0969-2126(99)80182-8  0.377
1999 Lawrence CC, Bennati M, Obias HV, Bar G, Griffin RG, Stubbe J. High-field EPR detection of a disulfide radical anion in the reduction of cytidine 5'-diphosphate by the E441Q R1 mutant of Escherichia coli ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 96: 8979-84. PMID 10430881 DOI: 10.1073/Pnas.96.16.8979  0.427
1999 Bennati M, Farrar CT, Bryant JA, Inati SJ, Weis V, Gerfen GJ, Riggs-Gelasco P, Stubbe J, Griffin RG. Pulsed electron-nuclear double resonance (ENDOR) at 140 GHz. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 138: 232-43. PMID 10341127 DOI: 10.1006/Jmre.1999.1727  0.711
1999 Licht SS, Lawrence CC, Stubbe J. Thermodynamic and kinetic studies on carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: the importance of entropy in catalysis. Biochemistry. 38: 1234-42. PMID 9930983 DOI: 10.1021/Bi981886A  0.566
1999 Licht SS, Booker S, Stubbe J. Studies on the catalysis of carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: evidence for concerted carbon-cobalt bond homolysis and thiyl radical formation. Biochemistry. 38: 1221-33. PMID 9930982 DOI: 10.1021/Bi981885I  0.712
1999 Müh U, Sinskey AJ, Kirby DP, Lane WS, Stubbe J. PHA synthase from chromatium vinosum: cysteine 149 is involved in covalent catalysis. Biochemistry. 38: 826-37. PMID 9888824 DOI: 10.1021/Bi9818319  0.348
1999 Licht SS, Lawrence CC, Stubbe J. Class II ribonucleotide reductases catalyze carbon-cobalt bond reformation on every turnover Journal of the American Chemical Society. 121: X. DOI: 10.1021/Ja9913840  0.581
1998 Stubbe J, van Der Donk WA. Protein Radicals in Enzyme Catalysis. [Chem. Rev. 1998, 98, 705minus sign762. Chemical Reviews. 98: 2661-2662. PMID 11848974 DOI: 10.1021/Cr980059C  0.56
1998 Stubbe J, van Der Donk WA. Protein Radicals in Enzyme Catalysis. Chemical Reviews. 98: 705-762. PMID 11848913  0.5
1998 Stubbe J, Riggs-Gelasco P. Harnessing free radicals: formation and function of the tyrosyl radical in ribonucleotide reductase Trends in Biochemical Sciences. 23: 438-443. PMID 9852763 DOI: 10.1016/S0968-0004(98)01296-1  0.758
1998 Wang W, Kappock TJ, Stubbe J, Ealick SE. X-ray crystal structure of glycinamide ribonucleotide synthetase from Escherichia coli. Biochemistry. 37: 15647-62. PMID 9843369 DOI: 10.1021/Bi981405N  0.341
1998 Lawrence CC, Stubbe J. The function of adenosylcobalamin in the mechanism of ribonucleoside triphosphate reductase from Lactobacillus leichmannii. Current Opinion in Chemical Biology. 2: 650-655. PMID 9818192 DOI: 10.1016/S1367-5931(98)80097-5  0.369
1998 van der Donk WA, Yu G, Pérez L, Sanchez RJ, Stubbe J, Samano V, Robins MJ. Detection of a new substrate-derived radical during inactivation of ribonucleotide reductase from Escherichia coli by gemcitabine 5'-diphosphate. Biochemistry. 37: 6419-26. PMID 9572859 DOI: 10.1021/Bi9729357  0.588
1998 Tong W, Burdi D, Riggs-Gelasco P, Chen S, Edmondson D, Huynh BH, Stubbe J, Han S, Arvai A, Tainer J. Characterization of Y122F R2 of Escherichia coli ribonucleotide reductase by time-resolved physical biochemical methods and X-ray crystallography. Biochemistry. 37: 5840-8. PMID 9558317 DOI: 10.1021/Bi9728811  0.751
1998 Silva DJ, Stubbe J, Samano V, Robins MJ. Gemcitabine 5'-triphosphate is a stoichiometric mechanism-based inhibitor of Lactobacillus leichmannii ribonucleoside triphosphate reductase: evidence for thiyl radical-mediated nucleotide radical formation. Biochemistry. 37: 5528-35. PMID 9548936 DOI: 10.1021/Bi972934E  0.384
1998 Stubbe J. Ribonucleotide reductases in the twenty-first century Proceedings of the National Academy of Sciences of the United States of America. 95: 2723-2724. PMID 9501154 DOI: 10.1073/Pnas.95.6.2723  0.306
1998 Burdi D, Willems J, Riggs-Gelasco P, Antholine WE, Stubbe J, Hoffman BM. The Core Structure of X Generated in the Assembly of the Diiron Cluster of Ribonucleotide Reductase: 17O2and H217O ENDOR Journal of the American Chemical Society. 120: 12910-12919. DOI: 10.1021/Ja9824270  0.745
1998 Boger DL, Ramsey TM, Cai H, Hoehn ST, Stubbe J. A Systematic Evaluation of the Bleomycin A2l-Threonine Side Chain:  Its Role in Preorganization of a Compact Conformation Implicated in Sequence-Selective DNA Cleavage Journal of the American Chemical Society. 120: 9139-9148. DOI: 10.1021/Ja9816638  0.304
1998 van der Donk WA, Gerfen GJ, Stubbe J. Direct EPR Spectroscopic Evidence for an Allylic Radical Generated from (E)-2‘-Fluoromethylene-2‘-deoxycytidine 5‘-Diphosphate byE.coliRibonucleotide Reductase Journal of the American Chemical Society. 120: 4252-4253. DOI: 10.1021/Ja9740273  0.349
1998 Wu W, Vanderwall DE, Teramoto S, Lui SM, Hoehn ST, Tang XJ, Turner CJ, Boger DL, Kozarich JW, Stubbe J. NMR studies of Co·deglycobleomycin A2 green and its complex with d(CCAGGCCTGG) Journal of the American Chemical Society. 120: 2239-2250. DOI: 10.1021/Ja972125I  0.32
1998 Riggs-Gelasco PJ, Shu L, Chen S, Burdi D, Huynh BH, Que L, Stubbe J. EXAFS Characterization of the Intermediate X Generated During the Assembly of the Escherichia coli Ribonucleotide Reductase R2 Diferric Tyrosyl Radical Cofactor Journal of the American Chemical Society. 120: 849-860. DOI: 10.1021/Ja9718230  0.753
1997 Vanderwall DE, Lui SM, Wu W, Turner CJ, Kozarich JW, Stubbe J. A model of the structure of HOO-Co.bleomycin bound to d(CCAGTACTGG): recognition at the d(GpT) site and implications for double-stranded DNA cleavage. Chemistry & Biology. 4: 373-87. PMID 9195876 DOI: 10.1016/S1074-5521(97)90128-9  0.302
1997 Burdi D, Aveline BM, Wood PD, Stubbe J, Redmond RW. Generation of a tryptophan radical in high quantum yield from a novel amino acid analog using near-UV/visible light Journal of the American Chemical Society. 119: 6457-6460. DOI: 10.1021/Ja9706918  0.398
1997 Lui SM, Vanderwall DE, Wu W, Tang XJ, Turner CJ, Kozarich JW, Stubbe J. Structural characterization of Co·Bleomycin A2 brown: Free and bound to d(CCAGGCCTGG) Journal of the American Chemical Society. 119: 9603-9613. DOI: 10.1021/Ja963889L  0.326
1997 Ashley GW, Lawrence CC, Stubbe J, Robins MJ. Mechanism based inactivation of the adenosylcobalamin-dependent ribonucleotide reductase from L. leichmannii by 2'-ara-2'-azido-2'-deoxy adenosine-5'-triphosphate: Observation of paramagnetic intermediates Tetrahedron. 53: 12005-12016. DOI: 10.1016/S0040-4020(97)00713-8  0.335
1996 van der Donk WA, Zeng C, Biemann K, Stubbe J, Hanlon A, Kyte J. Identification of an active site residue of the R1 subunit of ribonucleotide reductase from Escherichia coli: characterization of substrate-induced polypeptide cleavage by C225SR1. Biochemistry. 35: 10058-67. PMID 8756468 DOI: 10.1021/Bi952869D  0.533
1996 van der Donk WA, Yu G, Silva DJ, Stubbe J, McCarthy JR, Jarvi ET, Matthews DP, Resvick RJ, Wagner E. Inactivation of ribonucleotide reductase by (E)-2'-fluoromethylene-2'-deoxycytidine 5'-diphosphate: a paradigm for nucleotide mechanism-based inhibitors. Biochemistry. 35: 8381-91. PMID 8679596 DOI: 10.1021/Bi960190J  0.582
1996 Licht S, Gerfen GJ, Stubbe J. Thiyl radicals in ribonucleotide reductases. Science (New York, N.Y.). 271: 477-81. PMID 8560260 DOI: 10.1126/Science.271.5248.477  0.609
1996 Wodzinska J, Snell KD, Rhomberg A, Sinskey AJ, Biemann K, Stubbe J. Polyhydroxybutyrate synthase: Evidence for covalent catalysis Journal of the American Chemical Society. 118: 6319-6320. DOI: 10.1021/Ja961108A  0.307
1996 Gerfen GJ, Licht S, Willems JP, Hoffman BM, Stubbe J. Electron paramagnetic resonance investigations of a kinetically competent intermediate formed in ribonucleotide reduction: Evidence for a thiyl radical-cob(II)alamin interaction Journal of the American Chemical Society. 118: 8192-8197. DOI: 10.1021/Ja960363S  0.576
1996 Tong WH, Chen S, Lloyd SG, Edmondson DE, Huynh BH, Stubbe J. Mechanism of Assembly of the Diferric Cluster−Tyrosyl Radical Cofactor of Escherichia coli Ribonucleotide Reductase from the Diferrous Form of the R2 Subunit Journal of the American Chemical Society. 118: 2107-2108. DOI: 10.1021/Ja952764Y  0.403
1996 Burdi D, Sturgeon BE, Tong WH, Stubbe J, Hoffman BM. Rapid Freeze−Quench ENDOR of the Radical X Intermediate ofEscherichia coliRibonucleotide Reductase Using17O2, H217O, and2H2O Journal of the American Chemical Society. 118: 281-282. DOI: 10.1021/Ja952651E  0.342
1996 Wu W, Vanderwall DE, Turner CJ, Kozarich JW, Stubbe J. Solution structure of Co·Bleomycin A2 green complexed with d(CCAGGCCTGG) Journal of the American Chemical Society. 118: 1281-1294. DOI: 10.1021/Ja952497W  0.324
1996 Wu W, Vanderwall DE, Lui SM, Tang XJ, Turner CJ, Kozarich JW, Stubbe J. Studies of Co·Bleomycin A2 green: Its detailed structural characterization by NMR and molecular modeling and its sequence-specific interaction with DNA oligonucleotides Journal of the American Chemical Society. 118: 1268-1280. DOI: 10.1021/Ja9524964  0.305
1995 Stubbe J, van der Donk WA. Ribonucleotide reductases: radical enzymes with suicidal tendencies. Chemistry & Biology. 2: 793-801. PMID 8807812  0.508
1995 Bollinger JM, Tong WH, Ravi N, Huynh BH, Edmondson DE, Stubbe JA. Use of rapid kinetics methods to study the assembly of the diferric-tyrosyl radical cofactor of E. coli ribonucleotide reductase. Methods in Enzymology. 258: 278-303. PMID 8524156 DOI: 10.1016/0076-6879(95)58052-2  0.663
1995 Rudolph J, Stubbe J. Investigation of the mechanism of phosphoribosylamine transfer from glutamine phosphoribosylpyrophosphate amidotransferase to glycinamide ribonucleotide synthetase. Biochemistry. 34: 2241-2250. PMID 7532005 DOI: 10.1021/Bi00007A019  0.369
1995 Absalon MJ, Wu W, Kozarich JW, Stubbe J. Sequence-Specific Double-Strand Cleavage of DNA by Fe-Bleomycin. 2. Mechanism and Dynamics Biochemistry. 34: 2076-2086. PMID 7531499 DOI: 10.1021/Bi00006A030  0.355
1995 Absalon MJ, Kozarich JW, Stubbe J. Sequence-specific double-strand cleavage of DNA by Fe-bleomycin. 1. The detection of sequence-specific double-strand breaks using hairpin oligonucleotides. Biochemistry. 34: 2065-2075. PMID 7531498 DOI: 10.1021/Bi00006A029  0.324
1995 Pulver SC, Tong WH, Bollinger JM, Stubbe J, Solomon EI. Circular dichroism and magnetic circular dichroism studies of the fully reduced binuclear non-heme iron active site in the Escherichia coli R2 subunit of ribonucleoside diphosphate reductase Journal of the American Chemical Society. 117: 12664-12678. DOI: 10.1021/Ja00156A002  0.703
1995 Lai M, Wu W, Stubbe J. Characterization of a Novel, Stable Norcaradiene Adduct Resulting from the Inactivation of Thymine Hydroxylase by 5-Ethynyluracil Journal of the American Chemical Society. 117: 5023-5030. DOI: 10.1021/Ja00123A003  0.311
1994 Gerngross TU, Snell KD, Peoples OP, Sinskey AJ, Csuhai E, Masamune S, Stubbe J. Overexpression and purification of the soluble polyhydroxyalkanoate synthase from Alcaligenes eutrophus: evidence for a required posttranslational modification for catalytic activity. Biochemistry. 33: 9311-20. PMID 8049232 DOI: 10.1021/Bi00197A035  0.738
1994 Booker S, Licht S, Broderick J, Stubbe J. Coenzyme B12-dependent ribonucleotide reductase: evidence for the participation of five cysteine residues in ribonucleotide reduction. Biochemistry. 33: 12676-85. PMID 7918494 DOI: 10.1021/Bi00208A019  0.789
1994 Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ. Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms. Biochemistry. 33: 11927-34. PMID 7918411 DOI: 10.1021/Bi00205A031  0.335
1994 Bollinger JM, Tong WH, Ravi N, Huynh BH, Edmondson DE, Stubbe J. Mechanism of Assembly of the Tyrosyl Radical-Diiron(III) Cofactorof E. coli Ribonucleotide Reductase. 3. Kinetics of the Limiting Fe2+ Reaction by Optical, EPR, and Moessbauer Spectroscopies Journal of the American Chemical Society. 116: 8024-8032. DOI: 10.1021/Ja00097A009  0.696
1994 Ravi N, Bollinger JM, Huynh BH, Stubbe J, Edmondson DE. Mechanism of Assembly of the Tyrosyl Radical-Diiron(III) Cofactor of E. Coli Ribonucleotide Reductase: 1. Moessbauer Characterization of the Diferric Radical Precursor Journal of the American Chemical Society. 116: 8007-8014. DOI: 10.1021/Ja00097A007  0.712
1993 Booker S, Stubbe J. Cloning, sequencing, and expression of the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii Proceedings of the National Academy of Sciences of the United States of America. 90: 8352-8356. PMID 8397403 DOI: 10.1073/Pnas.90.18.8352  0.62
1993 Gerngross TU, Reilly P, Stubbe J, Sinskey AJ, Peoples OP. Immunocytochemical analysis of poly-beta-hydroxybutyrate (PHB) synthase in Alcaligenes eutrophus H16: localization of the synthase enzyme at the surface of PHB granules. Journal of Bacteriology. 175: 5289-93. PMID 8349571 DOI: 10.1128/Jb.175.16.5289-5293.1993  0.697
1993 Thornburg LD, Stubbe J. Mechanism-based inactivation of thymine hydroxylase, an α-ketoglutarate- dependent dioxygenase, by 5-ethynyluracil Biochemistry. 32: 14034-14042. PMID 8268182 DOI: 10.1021/Bi00213A037  0.351
1993 Thornburg LD, Lai MT, Wishnok JS, Stubbe J. A non-heme iron protein with heme tendencies: An investigation of the substrate specificity of thymine hydroxylase Biochemistry. 32: 14023-14033. PMID 8268181 DOI: 10.1021/Bi00213A036  0.39
1993 Salowe S, Bollinger JM, Ator M, Stubbe J, McCraken J, Peisach J, Samano MC, Robins MJ. Alternative model for mechanism-based inhibition of Escherichia coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine 5'-diphosphate. Biochemistry. 32: 12749-60. PMID 8251496 DOI: 10.1021/Bi00210A026  0.73
1993 Booker S, Broderick J, Stubbe J. Ribonucleotide reductases: Radical enzymes with suicidal tendencies Biochemical Society Transactions. 21: 727-730. PMID 8224499 DOI: 10.1042/Bst0210727  0.737
1993 Worth L, Frank BL, Christner DF, Absalon MJ, Stubbe J, Kozarich JW. Isotope effects on the cleavage of DNA by bleomycin: mechanism and modulation. Biochemistry. 32: 2601-2609. PMID 7680571 DOI: 10.1021/Bi00061A018  0.317
1993 Gerfen GJ, Bellew BF, Un S, Bollinger JM, Stubbe J, Griffin RG, Singel DJ. High-frequency (139.5 GHz) EPR spectroscopy of the tyrosyl radical in Escherichia coli ribonucleotide reductase Journal of the American Chemical Society. 115: 6420-6421. DOI: 10.1021/Ja00067A071  0.68
1993 Ravi N, Bollinger J, Tong W, Edmondson D, Stubbe J, Huynh B. A Mössbauer investigation of the kinetic intermediates involved in formation of the tyrosyl radical-diferric center cofactor in E. Coli ribonucleotide reductase Journal of Inorganic Biochemistry. 51: 276. DOI: 10.1016/0162-0134(93)85308-U  0.711
1993 Bollinger J, Ravi N, Tong W, Edmondson D, Huynh B, Stubbe J. Assembly of the iron center-tyrosyl radical cofactor of ribonucleotide reductase Journal of Inorganic Biochemistry. 51: 6. DOI: 10.1016/0162-0134(93)85045-A  0.682
1992 Mao SS, Yu GX, Chalfoun D, Stubbe J. Characterization of C439SR1, a mutant of Escherichia coli ribonucleotide diphosphate reductase: evidence that C439 is a residue essential for nucleotide reduction and C439SR1 is a protein possessing novel thioredoxin-like activity. Biochemistry. 31: 9752-9759. PMID 1390751 DOI: 10.1021/Bi00155A031  0.379
1992 Absalon MJ, Krishnamoorthy CR, McGall G, Kozarich JW, Stubbe J. Bleomycin mediated degradation of DNA-RNA hybrids does not involve C–1′ chemistry Nucleic Acids Research. 20: 4179-4185. PMID 1380696 DOI: 10.1093/Nar/20.16.4179  0.309
1992 Christner DF, Frank BL, Kozarich JW, Stubbe J, Golik J, Doyle TW, Rosenberg IE, Krishnan B. Unmasking the chemistry of DNA cleavage by the esperamicins : modulation of 4'-hydrogen abstraction and bistranded damage by the fucose-anthranilate moiety Journal of the American Chemical Society. 114: 8763-8767. DOI: 10.1021/Ja00049A002  0.302
1991 Baker CH, Banzon J, Bollinger JM, Stubbe J, Samano V, Robins MJ, Lippert B, Jarvi E, Resvick R. 2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase. Journal of Medicinal Chemistry. 34: 1879-84. PMID 2061926 DOI: 10.1021/Jm00110A019  0.704
1991 Kappen LS, Goldberg IH, Frank BL, Worth L, Christner DF, Kozarich JW, Stubbe J. Neocarzinostatin-induced hydrogen atom abstraction from C-4' and C-5' of the T residue at a d(GT) step in oligonucleotides: shuttling between deoxyribose attack sites based on isotope selection effects. Biochemistry. 30: 2034-2042. PMID 1825606 DOI: 10.1021/Bi00222A005  0.302
1991 Bollinger JM, Edmondson DE, Huynh BH, Filley J, Norton JR, Stubbe J. Mechanism of assembly of the tyrosyl radical-dinuclear iron cluster cofactor of ribonucleotide reductase. Science (New York, N.Y.). 253: 292-8. PMID 1650033 DOI: 10.1126/Science.1650033  0.712
1991 Bollinger JM, Stubbe J, Huynh BH, Edmondson DE. Novel diferric radical intermediate responsible for tyrosyl radical formation in assembly of the cofactor of ribonucleotide reductase Journal of the American Chemical Society. 113: 6289-6291. DOI: 10.1021/Ja00016A066  0.698
1991 Stubbe J. Dinuclear non-heme iron centers: structure and function Current Opinion in Structural Biology. 1: 788-795. DOI: 10.1016/0959-440X(91)90180-2  0.327
1991 Bollinger T, Edmondson D, Huynh B, Filley J, Norton J, Stubbe J. Mechanism of assembly of the tyrosyl radical-diferric cluster cofactor of E. coli ribonucleotide reductase. Journal of Inorganic Biochemistry. 43: 524. DOI: 10.1016/0162-0134(91)84499-Y  0.32
1989 Ashley GW, Harris G, Stubbe JA. Inactivation of the ribonucleoside triphosphate reductase from Lactobacillus leichmannii by 2'-chloro-2'-deoxyuridine 5'-triphosphate: a 3'-2' hydrogen transfer during the formation of 3'-keto-2'-deoxyuridine 5'-triphosphate. Biochemistry. 27: 7841-5. PMID 3061462 DOI: 10.1021/Bi00420A038  0.357
1989 Mao SS, Johnston MI, Bollinger JM, Stubbe J. Mechanism-based inhibition of a mutant Escherichia coli ribonucleotide reductase (cysteine-225----serine) by its substrate CDP. Proceedings of the National Academy of Sciences of the United States of America. 86: 1485-9. PMID 2493643 DOI: 10.1073/Pnas.86.5.1485  0.692
1989 Bender CJ, Sahlin M, Babcock GT, Barry BA, Chandrashekar TK, Salowe SP, Stubbe J, Lindstroem B, Petersson L. An ENDOR study of the tyrosyl free radical in ribonucleotide reductase from Escherichia coli Journal of the American Chemical Society. 111: 8076-8083. DOI: 10.1021/Ja00203A002  0.393
1989 Cole R, Frey P, Stubbe J, Sigman D. Abstracts, division of biological chemistry, 199th national meeting of the American chemical society, April 22-27, 1990 Biochemistry. 28: 2181-2204. DOI: 10.1021/Bi00430A600  0.453
1988 Ashley GW, Harris G, Stubbe J. Inactivation of the Lactobacillus leichmannii ribonucleoside triphosphate reductase by 2'-chloro-2'-deoxyuridine 5'-triphosphate: stoichiometry of inactivation, site of inactivation, and mechanism of the protein chromophore formation. Biochemistry. 27: 4305-10. PMID 3048383 DOI: 10.1021/Bi00412A017  0.38
1988 Stubbe J. Radicals in biological catalysis Biochemistry. 27: 3893-3900. PMID 3046660 DOI: 10.1021/Bi00411A001  0.339
1987 Lin ANI, Ashley GW, Stubbe J. Location of the redox-active thiols of ribonucleotide reductase: sequence similarity between the Escherichia coli and Lactobacillus leichmannii enzymes. Biochemistry. 26: 6905-6909. PMID 3322391 DOI: 10.1021/Bi00396A006  0.322
1987 Salowe SP, Ator MA, Stubbe J. Products of the inactivation of ribonucleoside diphosphate reductase from Escherichia coli with 2'-azido-2'-deoxyuridine 5'-diphosphate. Biochemistry. 26: 3408-3416. PMID 3307907 DOI: 10.1021/Bi00386A024  0.315
1987 Harris G, Ashley GW, Robins MJ, Tolman RL, Stubbe J. 2'-Deoxy-2'-halonucleotides as alternate substrates and mechanism-based inactivators of Lactobacillus leichmannii ribonucleotide reductase. Biochemistry. 26: 1895-902. PMID 3297135 DOI: 10.1021/Bi00381A017  0.359
1986 Ajmera S, Wu JC, Worth L, Rabow LE, Stubbe J, Kozarich JW. DNA degradation by bleomycin: evidence for 2'R-proton abstraction and for C-O bond cleavage accompanying base propenal formation. Biochemistry. 25: 6586-6592. PMID 2431710 DOI: 10.1021/Bi00369A037  0.37
1986 Wu JC, Stubbe J, Kozarich JW. Mechanism of bleomycin: evidence for 4'-ketone formation in poly(dA-dU) associated exclusively with free base release. Biochemistry. 24: 7569-73. PMID 2418869 DOI: 10.1021/Bi00347A010  0.322
1986 Wu JC, Kozarich JW, Stubbe J. Mechanism of bleomycin: evidence for a rate-determining 4'-hydrogen abstraction from poly(dA-dU) associated with the formation of both free base and base propenal. Biochemistry. 24: 7562-8. PMID 2418868 DOI: 10.1021/Bi00347A009  0.314
1985 Ator MA, Stubbe J. Mechanism of inactivation of Escherichia coli ribonucleotide reductase by 2'-chloro-2'-deoxyuridine 5'-diphosphate: evidence for generation of a 2'-deoxy-3'-ketonucleotide via a net 1,2 hydrogen shift. Biochemistry. 24: 7214-7221. PMID 3910098 DOI: 10.1021/Bi00346A029  0.35
1980 Stubbe J, Abeles RH. Mechanism of action of enolase: effect of the beta-hydroxy group on the rate of dissociation of the alpha-carbon-hydrogen bond. Biochemistry. 19: 5505-12. PMID 7006686 DOI: 10.1021/Bi00565A007  0.54
1972 Stubbe JA, Kenyon GL. Analogs of phosphoenolpyruvate. Substrate specificities of enolase and pyruvate kinase from rabbit muscle. Biochemistry. 11: 338-45. PMID 5062057 DOI: 10.1021/Bi00753A005  0.435
1971 Stubbe JA, Kenyon GL. Analogs of phosphoenolpyruvate. On the specificity of pyruvate kinase from rabbit muscle. Biochemistry. 10: 2669-77. PMID 5105182 DOI: 10.1021/Bi00790A003  0.416
Low-probability matches (unlikely to be authored by this person)
1988 Schendel FJ, Cheng YS, Otvos JD, Wehrli S, Stubbe J. Characterization and chemical properties of phosphoribosylamine, an unstable intermediate in the de novo purine biosynthetic pathway Biochemistry. 27: 2614-2623. PMID 2454658 DOI: 10.1021/Bi00407A052  0.3
2002 Wu W, Vanderwall DE, Turner CJ, Hoehn S, Chen J, Kozarich JW, Stubbe J. Solution structure of the hydroperoxide of Co(III) phleomycin complexed with d(CCAGGCCTGG)2: evidence for binding by partial intercalation. Nucleic Acids Research. 30: 4881-91. PMID 12433991 DOI: 10.1093/Nar/Gkf608  0.299
2014 Huang M, Parker MJ, Stubbe J. Choosing the right metal: case studies of class I ribonucleotide reductases. The Journal of Biological Chemistry. 289: 28104-11. PMID 25160629 DOI: 10.1074/Jbc.R114.596684  0.299
1984 Ator M, Salowe SP, Stubbe J, Emptage MH, Robins MJ. 2'-Azido-2'-deoxynucleotide interaction with E. coli ribonucleotide reductase: generation of a new radical species Journal of the American Chemical Society. 106: 1886-1887. DOI: 10.1021/Ja00318A082  0.298
2007 Stubbe J. Computational biochemistry: models of transition. Nature. 448: 762-3. PMID 17700688 DOI: 10.1038/448762A  0.297
2014 Zhang W, Shrestha R, Buckley RM, Jewell J, Bossmann SH, Stubbe J, Li P. Mechanistic insight with HBCH2CoA as a probe to polyhydroxybutyrate (PHB) synthases. Acs Chemical Biology. 9: 1773-9. PMID 24896226 DOI: 10.1021/Cb5002735  0.295
1992 Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM. Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway. Biochemistry. 31: 5022-32. PMID 1534690 DOI: 10.1021/Bi00136A016  0.294
2008 Hassan AQ, Stubbe J. Mapping the subunit interface of ribonucleotide reductase (RNR) using photo cross-linking. Bioorganic & Medicinal Chemistry Letters. 18: 5923-5. PMID 18762419 DOI: 10.1016/J.Bmcl.2008.08.048  0.294
1993 Pulver S, Martin Bollinger J, Froland WA, Lipscomb JD, Stubbe J, Solomon EI. Structure-function correlations over coupled binuclear non-heme iron enzymes Journal of Inorganic Biochemistry. 51: 63. DOI: 10.1016/0162-0134(93)85099-T  0.294
2000 Kappock TJ, Ealick SE, Stubbe J. Modular evolution of the purine biosynthetic pathway. Current Opinion in Chemical Biology. 4: 567-72. PMID 11006546 DOI: 10.1016/S1367-5931(00)00133-2  0.293
2002 Junker HD, Hoehn ST, Bunt RC, Marathius V, Chen J, Turner CJ, Stubbe J. Synthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3'-phosphoglycolate, 5'-phosphate gapped lesion. Nucleic Acids Research. 30: 5497-508. PMID 12490718 DOI: 10.1093/Nar/Gkf681  0.292
2002 York GM, Stubbe J, Sinskey AJ. The Ralstonia eutropha PhaR protein couples synthesis of the PhaP phasin to the presence of polyhydroxybutyrate in cells and promotes polyhydroxybutyrate production. Journal of Bacteriology. 184: 59-66. PMID 11741844 DOI: 10.1128/Jb.184.1.59-66.2002  0.291
1975 Appelbaum J, Stubbe J. Enolase catalyzed β,γ-α,β isomerization of 2-phospho-3-butenoic acid to (Z)-phosphoenol-α-ketobutyrate Biochemistry. 14: 3908-3912. PMID 240397 DOI: 10.1021/Bi00688A027  0.288
2003 York GM, Lupberger J, Tian J, Lawrence AG, Stubbe J, Sinskey AJ. Ralstonia eutropha H16 encodes two and possibly three intracellular poly[D-(-)-3-hydroxybutyrate] depolymerase genes Journal of Bacteriology. 185: 3788-3794. PMID 12813072 DOI: 10.1128/Jb.185.13.3788-3794.2003  0.288
1994 Stubbe J. Controlling radical reactions Nature. 370: 502-502. PMID 8052304 DOI: 10.1038/370502A0  0.288
2018 Thomas WC, Brooks FP, Parker MJ, Case DA, Kaelber JT, Stubbe J, Chen J, Ando N. A novel form of allosteric regulation in Bacillus subtilis ribonucleotide reductase revealed by SAXS and cryo-electron microscopy Acta Crystallographica Section a Foundations and Advances. 74: a85-a85. DOI: 10.1107/S0108767318099142  0.288
2009 Zipse H, Artin E, Wnuk S, Lohman GJ, Martino D, Griffin RG, Kacprzak S, Kaupp M, Hoffman B, Bennati M, Stubbe J, Lees N. Structure of the nucleotide radical formed during reaction of CDP/TTP with the E441Q-alpha2beta2 of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 131: 200-11. PMID 19128178 DOI: 10.1021/Ja806693S  0.287
1992 McGall GH, Rabow LE, Ashley GW, Wu SH, Kozarich JW, Stubbe J. New insight into the mechanism of base propenal formation during bleomycin-mediated DNA degradation Journal of the American Chemical Society. 114: 4958-4967. DOI: 10.1021/Ja00039A002  0.286
2008 Lee YD, Wang J, Stubbe J, Elledge SJ. Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase. Molecular Cell. 32: 70-80. PMID 18851834 DOI: 10.1016/J.Molcel.2008.08.018  0.285
1997 Bansal M, Lee JS, Kozarich JW, Stubbe J. Mechanistic analyses of site-specific degradation in DNA-RNA hybrids by prototypic DNA cleavers Nucleic Acids Research. 25: 1836-1845. PMID 9108169 DOI: 10.1093/Nar/25.9.1836  0.282
2003 Stubbe J, Tian J. Polyhydroxyalkanoate (PHA) homeostasis: The role of the PHA synthase Natural Product Reports. 20: 445-457. PMID 14620841 DOI: 10.1039/B209687K  0.281
1987 Mcgall GH, Rabow LE, Stubbe J, Kozarich JW. Incorporation of 18O into glycolic acid obtained from the bleomycin-mediated degradation of DNA: evidence for 4'-radical trapping by 18O2 Journal of the American Chemical Society. 109: 2836-2837. DOI: 10.1021/Ja00243A053  0.28
1991 Frank BL, Worth L, Christner DF, Kozarich JW, Stubbe J, Kappen LS, Goldberg IH. Isotope effects on the sequence-specific cleavage of DNA by neocarzinostatin: kinetic partitioning between 4'- and 5'-hydrogen abstraction at unique thymidine sites Journal of the American Chemical Society. 113: 2271-2275. DOI: 10.1021/Ja00006A054  0.279
1997 Bansal M, Stubbe J, Kozarich JW. Effects of hypoxanthine substitution on bleomycin-mediated DNA strand degradation in DNA-RNA hybrids Nucleic Acids Research. 25: 1846-1853. PMID 9108170 DOI: 10.1093/Nar/25.9.1846  0.279
1986 Scarrow RC, Maroney MJ, Palmer SM, Que L, Salowe SP, Stubbe J. EXAFS Studies of the B2 Subunit of the Ribonucleotide Reductase from E. coli Journal of the American Chemical Society. 108: 6832-6834. DOI: 10.1021/Ja00281A077  0.278
2005 Stubbe J, Tian J, He A, Sinskey AJ, Lawrence AG, Liu P. Nontemplate-dependent polymerization processes: polyhydroxyalkanoate synthases as a paradigm. Annual Review of Biochemistry. 74: 433-80. PMID 15952894 DOI: 10.1146/Annurev.Biochem.74.082803.133013  0.276
1996 Stubbe J, Kozarich JW, Wu W, Vanderwall DE. Bleomycins : A Structural Model For Specificity, Binding, And Double Strand Cleavage Accounts of Chemical Research. 29: 322-330. DOI: 10.1021/Ar9501333  0.276
1998 Boger DL, Ramsey TM, Cai H, Hoehn ST, Stubbe J. Definition of the Effect and Role of the Bleomycin A2Valerate Substituents:  Preorganization of a Rigid, Compact Conformation Implicated in Sequence-Selective DNA Cleavage Journal of the American Chemical Society. 120: 9149-9158. DOI: 10.1021/Ja9816640  0.273
1998 Boger DL, Ramsey TM, Cai H, Hoehn ST, Kozarich JW, Stubbe J. Assessment of the Role of the Bleomycin A2Pyrimidoblamic Acid C4 Amino Group Journal of the American Chemical Society. 120: 53-65. DOI: 10.1021/Ja971889V  0.273
2014 Makhlynets O, Boal AK, Rhodes DV, Kitten T, Rosenzweig AC, Stubbe J. Streptococcus sanguinis class Ib ribonucleotide reductase: high activity with both iron and manganese cofactors and structural insights. The Journal of Biological Chemistry. 289: 6259-72. PMID 24381172 DOI: 10.1074/Jbc.M113.533554  0.273
2005 Lawrence AG, Schoenheit J, He A, Tian J, Liu P, Stubbe J, Sinskey AJ. Transcriptional analysis of Ralstonia eutropha genes related to poly-(R)-3-hydroxybutyrate homeostasis during batch fermentation. Applied Microbiology and Biotechnology. 68: 663-72. PMID 15924243 DOI: 10.1007/S00253-005-1969-3  0.273
2005 Tian J, Sinskey AJ, Stubbe J. Kinetic studies of polyhydroxybutyrate granule formation in Wautersia eutropha H16 by transmission electron microscopy Journal of Bacteriology. 187: 3814-3824. PMID 15901706 DOI: 10.1128/Jb.187.11.3814-3824.2005  0.272
1991 McGall GH, Stubbe J, Kozarich JW. Acyl migration in the production of thymine. Propenal from 3'-O-benzoyl-5'-deoxy-4'-(hydroperoxy)thymidine: a reinterpretation of a putative model for bleomycin-mediated DNA degradation Journal of Organic Chemistry. 56: 48-55. DOI: 10.1021/Jo00001A011  0.27
2013 Dowhan W, Nikaido H, Stubbe J, Kozarich JW, Wickner WT, Russell DW, Garrett TA, Brozek K, Modrich P. Christian Raetz: scientist and friend extraordinaire. Annual Review of Biochemistry. 82: 1-24. PMID 23472605 DOI: 10.1146/Annurev-Biochem-012512-091530  0.268
2011 Thompson LR, Zeng Q, Kelly L, Huang KH, Singer AU, Stubbe J, Chisholm SW. Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism. Proceedings of the National Academy of Sciences of the United States of America. 108: E757-64. PMID 21844365 DOI: 10.1073/Pnas.1102164108  0.268
2001 York GM, Stubbe J, Sinskey AJ. New insight into the role of the PhaP phasin of Ralstonia eutropha in promoting synthesis of polyhydroxybutyrate. Journal of Bacteriology. 183: 2394-7. PMID 11244085 DOI: 10.1128/Jb.183.7.2394-2397.2001  0.268
1989 Kozarich J, Worth L, Frank B, Christner D, Vanderwall D, Stubbe J. Sequence-specific isotope effects on the cleavage of DNA by bleomycin Science. 245: 1396-1399. PMID 2476851 DOI: 10.1126/Science.2476851  0.266
2005 Chen J, Stubbe J. Bleomycins: Towards better therapeutics Nature Reviews Cancer. 5: 102-112. PMID 15685195 DOI: 10.1038/Nrc1547  0.265
1994 Stubbe J. Binding site revealed of nature's most beautiful cofactor Science. 266: 1663-1664. PMID 7992049 DOI: 10.1126/Science.7992049  0.265
2004 Chen J, Stubbe J. Bleomycins: New methods will allow reinvestigation of old issues Current Opinion in Chemical Biology. 8: 175-181. PMID 15062779 DOI: 10.1016/J.Cbpa.2004.02.008  0.265
2010 Mühlenhoff U, Molik S, Godoy JR, Uzarska MA, Richter N, Seubert A, Zhang Y, Stubbe J, Pierrel F, Herrero E, Lillig CH, Lill R. Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster. Cell Metabolism. 12: 373-85. PMID 20889129 DOI: 10.1016/J.Cmet.2010.08.001  0.264
2002 Drennan CL, Sintchak MD, Arjara G, Kellogg BA, Stubbe J. Crystal structure of class II ribonucleotide reductase: how an allosterically regulated monomer mimics a dimer Acta Crystallographica Section a Foundations of Crystallography. 58: c193-c193. DOI: 10.1107/S0108767302092723  0.263
2012 Stubbe J. Preface and Dedicationto Christian R.H. Raetz Annual Review of Biochemistry. 81. DOI: 10.1146/Annurev-Bi-81-060412-100001  0.262
2009 Minnihan EC, Yokoyama K, Stubbe J. Unnatural amino acids: better than the real things? F1000 Biology Reports. 1: 88. PMID 20948602 DOI: 10.3410/B1-88  0.262
1990 Cheng YS, Rudolph J, Stern M, Stubbe J, Flannigan KA, Smith JM. Glycinamide ribonucleotide synthetase from Escherichia coli: cloning, overproduction, sequencing, isolation, and characterization [Erratum to document cited in CA112(5):31307r] Biochemistry. 29: 5220-5220. DOI: 10.1021/Bi00473A031  0.26
2012 Stubbe J. Christian R. Raetz (1946–2011) Acs Chemical Biology. 7: 12-13. DOI: 10.1021/Cb2004862  0.258
2012 Beeby M, Cho M, Stubbe J, Jensen GJ. Growth and localization of polyhydroxybutyrate granules in Ralstonia eutropha. Journal of Bacteriology. 194: 1092-9. PMID 22178974 DOI: 10.1128/Jb.06125-11  0.257
2001 York GM, Junker BH, Stubbe JA, Sinskey AJ. Accumulation of the PhaP phasin of Ralstonia eutropha is dependent on production of polyhydroxybutyrate in cells. Journal of Bacteriology. 183: 4217-26. PMID 11418562 DOI: 10.1128/Jb.183.14.4217-4226.2001  0.254
1988 Krishnamoorthy CR, Vanderwall DE, Kozarich JW, Stubbe J. Degradation of DNA-RNA hybrids by bleomycin: evidence for DNA strand specificity and for possible structural modulation of chemical mechanism Journal of the American Chemical Society. 110: 2008-2009. DOI: 10.1021/Ja00214A079  0.253
2019 Thomas WC, Brooks FP, Burnim AA, Bacik J, Stubbe J, Kaelber JT, Chen J, Ando N. Mapping allosteric transitions of an enzyme with SAXS, cryo-EM and crystallography Acta Crystallographica Section a Foundations and Advances. 75: a14-a14. DOI: 10.1107/S0108767319099859  0.247
1987 Sheats JE, Czernuszewicz RS, Dismukes GC, Rheingold AL, Petrouleas V, Stubbe J, Armstrong WH, Beer RH, Lippard SJ. Binuclear manganese(III) complexes of potential biological significance Journal of the American Chemical Society. 109: 1435-1444. DOI: 10.1021/Ja00239A025  0.246
1996 Stubbe J. One of Nature's Macromolecular Machines Demystified Science. 274: 1152-1153. PMID 8966589 DOI: 10.1126/Science.274.5290.1152  0.246
1989 Thornburg LD, Stubbe J. Mechanism-based inhibition of thymine hydroxylase Journal of the American Chemical Society. 111: 7632-7633. DOI: 10.1021/Ja00201A064  0.244
1989 Stubbe J, Rabow L, McGall G, Absalon M, Kozarich JW, Frank LB, Worth L, Cristner D, Krishnamoorthy CR. Bleomycin: Mechanism of action and probe of DNA conformation Journal of Inorganic Biochemistry. 36: 155. DOI: 10.1016/0162-0134(89)84034-6  0.242
1985 Ashley GW, Stubbe J. Current ideas on the chemical mechanism of ribonucleotide reductases. Pharmacology & Therapeutics. 30: 301-329. PMID 3916287 DOI: 10.1016/0163-7258(85)90054-3  0.238
1990 Rabow LE, Stubbe J, Kozarich JW, McGall GH. Identification of the source of oxygen in the alkaline-labile product accompanying cytosine release during bleomycin-mediated oxidative degradation of d(CGCGCG) Journal of the American Chemical Society. 112: 3203-3208. DOI: 10.1021/Ja00164A050  0.238
1987 Stubbe J, Kozarich JW. Mechanisms of bleomycin-induced DNA degradation Chemical Reviews. 87: 1107-1136. DOI: 10.1021/Cr00081A011  0.238
2015 Wei Y, Li B, Prakash D, Ferry JG, Elliott SJ, Stubbe J. A ferredoxin disulfide reductase delivers electrons to the Methanosarcina barkeri class III ribonucleotide reductase. Biochemistry. PMID 26536144 DOI: 10.1021/Acs.Biochem.5B01092  0.23
1996 Stubbe J, Johnson LN. Catalysis and regulation. Current Opinion in Structural Biology. 6: 733-735. PMID 9000033 DOI: 10.1016/S0959-440X(96)80001-7  0.225
1990 Rabow LE, Stubbe J, Kozarich JW. Identification and quantitation of the lesion accompanying base release in bleomycin-mediated DNA degradation Journal of the American Chemical Society. 112: 3196-3203. DOI: 10.1021/Ja00164A049  0.224
2015 Doan PE, Shanmugam M, Stubbe J, Hoffman BM. Composition and Structure of the Inorganic Core of Relaxed Intermediate X(Y122F) of Escherichia coli Ribonucleotide Reductase. Journal of the American Chemical Society. PMID 26636616 DOI: 10.1021/Jacs.5B10763  0.222
2009 Shanmugam M, Doan PE, Lees NS, Stubbe J, Hoffman BM. Identification of protonated oxygenic ligands of ribonucleotide reductase intermediate X. Journal of the American Chemical Society. 131: 3370-6. PMID 19220056 DOI: 10.1021/Ja809223S  0.22
1980 Stubbe J, Kozarich JW. Inorganic pyrophosphate is released from 2'-chloro-2'-deoxyuridine 5'-diphosphate by ribonucleoside diphosphate reductase Journal of the American Chemical Society. 102: 2505-2507. DOI: 10.1021/Ja00527A084  0.218
1986 Rabow L, Stubbe J, Kozarich JW, Gerlt JA. Identification of the alkaline-labile product accompanying cytosine release during bleomycin-mediated degradation of d(CGCGCG) Journal of the American Chemical Society. 108: 7130-7131. DOI: 10.1021/Ja00282A063  0.217
1998 Stubbe J, Johnson LN. Catalysis and regulation. Channels, terpenes and phosphates Current Opinion in Structural Biology. 8: 675-678. DOI: 10.1016/S0959-440X(98)80085-7  0.215
2021 Hecker F, Stubbe J, Bennati M. Detection of Water Molecules on the Radical Transfer Pathway of Ribonucleotide Reductase by O Electron-Nuclear Double Resonance Spectroscopy. Journal of the American Chemical Society. 143: 7237-7241. PMID 33957040 DOI: 10.1021/jacs.1c01359  0.214
2018 Parker MJ, Maggiolo AO, Thomas WC, Kim A, Meisburger SP, Ando N, Boal AK, Stubbe J. An endogenous dAMP ligand in class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proceedings of the National Academy of Sciences of the United States of America. PMID 29712847 DOI: 10.1073/Pnas.1800356115  0.212
2014 Rhodes DV, Crump KE, Makhlynets O, Snyder M, Ge X, Xu P, Stubbe J, Kitten T. Genetic characterization and role in virulence of the ribonucleotide reductases of Streptococcus sanguinis. The Journal of Biological Chemistry. 289: 6273-87. PMID 24381171 DOI: 10.1074/Jbc.M113.533620  0.212
2000 Stubbe J, Johnson LN. Clarity through structures. Editorial overview. Current Opinion in Structural Biology. 10: 709-710. PMID 11114508 DOI: 10.1016/S0959-440X(00)00160-3  0.21
2011 Wickner WT, Stubbe J, Hirschberg CB, Garrett T, Dowhan W. Chris Raetz, scientist and enduring friend. Proceedings of the National Academy of Sciences of the United States of America. 108: 17255-6. PMID 21969572 DOI: 10.1073/Pnas.1114405108  0.209
1990 Kappen LS, Goldberg IH, Wu SH, Stubbe J, Worth L, Kozarich JW. Isotope effects on the sequence-specific cleavage of dC in d(AGC) sequences by neocarzinostatin: elucidation of chemistry of minor lesions Journal of the American Chemical Society. 112: 2797-2798. DOI: 10.1021/Ja00163A049  0.209
2001 Stubbe J, Ringe D. Robert H. Abeles (1926–2000) Trends in Biochemical Sciences. 26: 74-75. DOI: 10.1016/S0968-0004(00)01736-9  0.196
1994 Wu W, Vanderwall DE, Stubbe J, Kozarich JW, Turner CJ. Interaction of Co·bleomycin A2 (green) with d(CCAGGCCTGG)2: Evidence for intercalation using 2D NMR Journal of the American Chemical Society. 116: 10843-10844. DOI: 10.1021/Ja00102A083  0.185
2011 Stubbe J. Past, Present, and Future Triumphs of Biochemistry Annual Review of Biochemistry. 80. DOI: 10.1146/Annurev-Bi-80-060111-100001  0.185
1983 Stubbe JA. Mechanism of B12-dependent ribonucleotide reductase. Molecular and Cellular Biochemistry. 50: 25-45. PMID 6341812 DOI: 10.1007/BF00225278  0.178
2020 O'Reilly M, Stubbe J. PET Polymer Recycling. Biochemistry. 59: 2316-2318. PMID 32559062 DOI: 10.1021/Acs.Biochem.0C00457  0.178
2021 Pokern Y, Eltzner B, Huckemann SF, Beeken C, Stubbe J, Tkach I, Bennati M, Hiller M. Statistical analysis of ENDOR spectra. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34215694 DOI: 10.1073/pnas.2023615118  0.17
2004 Stubbe J. Radicals with a controlled lifestyle. Chemical Communications (Cambridge, England). 2511-3. PMID 14594260 DOI: 10.1039/b307617m  0.142
2007 Chen B, Zhou X, Taghizadeh K, Chen J, Stubbe J, Dedon PC. GC/MS methods to quantify the 2-deoxypentos-4-ulose and 3'-phosphoglycolate pathways of 4' oxidation of 2-deoxyribose in DNA: application to DNA damage produced by gamma radiation and bleomycin. Chemical Research in Toxicology. 20: 1701-8. PMID 17944541 DOI: 10.1021/tx700164y  0.137
2009 Svenningsen P, Bistrup C, Friis UG, Bertog M, Haerteis S, Krueger B, Stubbe J, Jensen ON, Thiesson HC, Uhrenholt TR, Jespersen B, Jensen BL, Korbmacher C, Skøtt O. Plasmin in nephrotic urine activates the epithelial sodium channel. Journal of the American Society of Nephrology : Jasn. 20: 299-310. PMID 19073825 DOI: 10.1681/ASN.2008040364  0.134
2022 Narasimhan J, Letinski S, Jung SP, Gerasyuto A, Wang J, Arnold M, Chen G, Hedrick J, Dumble M, Ravichandran K, Levitz T, Chang C, Drennan CL, Stubbe J, Karp G, et al. Ribonucleotide reductase, a novel drug target for gonorrhea. Elife. 11. PMID 35137690 DOI: 10.7554/eLife.67447  0.115
2009 Yu Y, Lucitt MB, Stubbe J, Cheng Y, Friis UG, Hansen PB, Jensen BL, Smyth EM, FitzGerald GA. Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. 106: 7985-90. PMID 19416858 DOI: 10.1073/Pnas.0811834106  0.109
2006 Stubbe J. EURELECTRIC'S view on R&D needs Vgb Powertech. 86: 30-33+6.  0.101
2012 Havelund T, Jensen BL, Vinholt PJ, Engvad B, Stubbe J. Ulcerating and stenosing enteropathy treated with misoprostol: a case report with analysis of prostaglandin metabolism. European Journal of Gastroenterology & Hepatology. 24: 1238-41. PMID 22786573 DOI: 10.1097/MEG.0b013e328356bc95  0.088
2013 Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skøtt O, Jensen BL. Regulation of renin secretion by renal juxtaglomerular cells. PflüGers Archiv : European Journal of Physiology. 465: 25-37. PMID 22733355 DOI: 10.1007/s00424-012-1126-7  0.085
2004 Jensen BL, Stubbe J, Madsen K, Nielsen FT, Skøtt O. The renin-angiotensin system in kidney development: Role of COX-2 and adrenal steroids Acta Physiologica Scandinavica. 181: 549-559. PMID 15283770 DOI: 10.1111/j.1365-201X.2004.01330.x  0.083
2010 Harrell EM, Stubbe J. Universal bounds and semiclassical estimates for eigenvalues of abstract Schrödinger operators Siam Journal On Mathematical Analysis. 42: 2261-2274. DOI: 10.1137/090763743  0.07
2013 Øzbay LA, Stubbe J, Jespersen B, Jensen BL. The effects of calcineurin inhibitors on prostanoid synthesis: a randomized cross-over study in healthy humans. Transplant International : Official Journal of the European Society For Organ Transplantation. 26: 131-7. PMID 23190385 DOI: 10.1111/tri.12004  0.07
2006 Stubbe J, Madsen K, Nielsen FT, Skøtt O, Jensen BL. Glucocorticoid impairs growth of kidney outer medulla and accelerates loop of Henle differentiation and urinary concentrating capacity in rat kidney development American Journal of Physiology - Renal Physiology. 291: F812-F822. PMID 16638911 DOI: 10.1152/ajprenal.00477.2005  0.065
2005 Friis UG, Stubbe J, Uhrenholt TR, Svenningsen P, Nüsing RM, Skøtt O, Jensen BL. Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cells American Journal of Physiology - Renal Physiology. 289: F989-F997. PMID 15985651 DOI: 10.1152/ajprenal.00201.2005  0.062
2014 Eskildsen MP, Hansen PB, Stubbe J, Toft A, Walter S, Marcussen N, Rasmussen LM, Vanhoutte PM, Jensen BL. Prostaglandin I2 and prostaglandin E2 modulate human intrarenal artery contractility through prostaglandin E2-EP4, prostacyclin-IP, and thromboxane A2-TP receptors. Hypertension. 64: 551-6. PMID 24914192 DOI: 10.1161/HYPERTENSIONAHA.113.03051  0.062
2012 Song WL, Stubbe J, Ricciotti E, Alamuddin N, Ibrahim S, Crichton I, Prempeh M, Lawson JA, Wilensky RL, Rasmussen LM, Puré E, FitzGerald GA. Niacin and biosynthesis of PGDâ‚‚by platelet COX-1 in mice and humans. The Journal of Clinical Investigation. 122: 1459-68. PMID 22406532 DOI: 10.1172/Jci59262  0.062
2013 Damkjær M, Isaksson GL, Stubbe J, Jensen BL, Assersen K, Bie P. Renal renin secretion as regulator of body fluid homeostasis. PflüGers Archiv : European Journal of Physiology. 465: 153-65. PMID 23096366 DOI: 10.1007/s00424-012-1171-2  0.062
2010 Hui Y, Ricciotti E, Crichton I, Yu Z, Wang D, Stubbe J, Wang M, Puré E, FitzGerald GA. Targeted deletions of cyclooxygenase-2 and atherogenesis in mice. Circulation. 121: 2654-60. PMID 20530000 DOI: 10.1161/Circulationaha.109.910687  0.061
2006 Ligthart L, Boomsma DI, Martin NG, Stubbe JH, Nyholt DR. Migraine with aura and migraine without aura are not distinct entities: Further evidence from a large Dutch population study Twin Research and Human Genetics. 9: 54-63. PMID 16611468 DOI: 10.1375/183242706776403019  0.061
2003 Stubbe J, Jensen BL, Bachmann S, Morsing P, Skøtt O. Cyclooxygenase-2 contributes to elevated renin in the early postnatal period in rats American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 284: R1179-R1189. PMID 12560203  0.059
2010 Yu Y, Stubbe J, Ibrahim S, Song WL, Smyth EM, Symth EM, Funk CD, FitzGerald GA. Cyclooxygenase-2-dependent prostacyclin formation and blood pressure homeostasis: targeted exchange of cyclooxygenase isoforms in mice. Circulation Research. 106: 337-45. PMID 19940265 DOI: 10.1161/Circresaha.109.204529  0.058
2011 Harrell EM, Stubbe J. Trace identities for commutators, with applications to the distribution of eigenvalues Transactions of the American Mathematical Society. 363: 6385-6405. DOI: 10.1090/S0002-9947-2011-05252-9  0.052
2004 Madsen K, Stubbe J, Yang T, Skøtt O, Bachmann S, Jensen BL. Low endogenous glucocorticoid allows induction of kidney cortical cyclooxygenase-2 during postnatal rat development American Journal of Physiology - Renal Physiology. 286: F26-F37. PMID 13129852  0.052
2014 Isaksson GL, Stubbe J, Lyngs Hansen P, Jensen BL, Bie P. Salt sensitivity of renin secretion, glomerular filtration rate and blood pressure in conscious Sprague-Dawley rats. Acta Physiologica (Oxford, England). 210: 446-54. PMID 24188244 DOI: 10.1111/apha.12191  0.05
2006 Hillman CH, Motl RW, Pontifex MB, Posthuma D, Stubbe JH, Boomsma DI, de Geus EJ. Physical activity and cognitive function in a cross-section of younger and older community-dwelling individuals. Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association. 25: 678-87. PMID 17100496 DOI: 10.1037/0278-6133.25.6.678  0.047
2014 Harrell EM, Stubbe J. On sums of graph eigenvalues Linear Algebra and Its Applications. 455: 168-186. DOI: 10.1016/J.Laa.2014.05.001  0.047
2014 Stubbe JH, Chorus AM, Frank LE, de Hon O, van der Heijden PG. Prevalence of use of performance enhancing drugs by fitness centre members. Drug Testing and Analysis. 6: 434-8. PMID 24019293 DOI: 10.1002/dta.1525  0.046
2004 Therland KL, Stubbe J, Thiesson HC, Ottosen PD, Walter S, Sørensen GL, Skøtt O, Jensen BL. Cycloxygenase-2 Is Expressed in Vasculature of Normal and Ischemic Adult Human Kidney and Is Colocalized with Vascular prostaglandin E2 EP4 Receptors Journal of the American Society of Nephrology. 15: 1189-1198. PMID 15100359 DOI: 10.1097/01.ASN.0000124673.79934.24  0.045
2007 Stubbe J, Madsen K, Nielsen FT, Bonde RK, Skøtt O, Jensen BL. Postnatal adrenalectomy impairs urinary concentrating ability by increased COX-2 and leads to renal medullary injury American Journal of Physiology - Renal Physiology. 293: F780-F789. PMID 17581922 DOI: 10.1152/ajprenal.00193.2007  0.042
2015 Schlosser A, Pilecki B, Hemstra LE, Kejling K, Kristmannsdottir GB, Wulf-Johansson H, Moeller JB, Füchtbauer EM, Nielsen O, Kirketerp-Møller K, Dubey LK, Hansen PB, Stubbe J, Wrede C, Hegermann J, et al. MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26564819 DOI: 10.1161/ATVBAHA.115.306672  0.039
2011 Vink JM, Boomsma DI, Medland SE, de Moor MH, Stubbe JH, Cornes BK, Martin NG, Skytthea A, Kyvik KO, Rose RJ, Kujala UM, Kaprio J, Harris JR, Pedersen NL, Cherkas L, et al. Variance components models for physical activity with age as modifier: a comparative twin study in seven countries. Twin Research and Human Genetics : the Official Journal of the International Society For Twin Studies. 14: 25-34. PMID 21314253 DOI: 10.1375/Twin.14.1.25  0.039
2010 Stubbe J, Vuffray M. Bound states of the Schrödinger-Newton model in low dimensions Nonlinear Analysis, Theory, Methods and Applications. 73: 3171-3178. DOI: 10.1016/j.na.2010.06.072  0.039
2014 Tinning AR, Jensen BL, Schweda F, Machura K, Hansen PB, Stubbe J, Gramsbergen JB, Madsen K. The water channel aquaporin-1 contributes to renin cell recruitment during chronic stimulation of renin production. American Journal of Physiology. Renal Physiology. 307: F1215-26. PMID 25339696 DOI: 10.1152/ajprenal.00136.2014  0.037
2011 De Moor MH, Willemsen G, Rebollo-Mesa I, Stubbe JH, De Geus EJ, Boomsma DI. Exercise participation in adolescents and their parents: evidence for genetic and generation specific environmental effects. Behavior Genetics. 41: 211-22. PMID 21086156 DOI: 10.1007/s10519-010-9415-4  0.036
2011 van Beijsterveldt AM, Krist MR, Schmikli SL, Stubbe JH, de Wit GA, Inklaar H, van de Port IG, Backx FJ. Effectiveness and cost-effectiveness of an injury prevention programme for adult male amateur soccer players: design of a cluster-randomised controlled trial. Injury Prevention : Journal of the International Society For Child and Adolescent Injury Prevention. 17: e2. PMID 21177664 DOI: 10.1136/ip.2010.027979  0.036
2007 De Moor MHM, Stubbe JH, Boomsma DI, De Geus EJC. Exercise participation and self-rated health: Do common genes explain the association? European Journal of Epidemiology. 22: 27-32. PMID 17195050 DOI: 10.1007/s10654-006-9088-8  0.032
2005 Middeldorp CM, Stubbe JH, Cath DC, Boomsma DI. Familial clustering in burnout: A twin-family study Psychological Medicine. 35: 113-120. PMID 15842034 DOI: 10.1017/S0033291704002983  0.03
2009 Damman OC, Stubbe JH, Hendriks M, Arah OA, Spreeuwenberg P, Delnoij DM, Groenewegen PP. Using multilevel modeling to assess case-mix adjusters in consumer experience surveys in health care. Medical Care. 47: 496-503. PMID 19238105 DOI: 10.1097/Mlr.0B013E31818Afa05  0.029
2015 Tak I, Weir A, Langhout R, Waarsing JH, Stubbe J, Kerkhoffs G, Agricola R. The relationship between the frequency of football practice during skeletal growth and the presence of a cam deformity in adult elite football players. British Journal of Sports Medicine. 49: 630-4. PMID 25568331 DOI: 10.1136/bjsports-2014-094130  0.029
2012 van Beijsterveldt AM, van de Port IG, Krist MR, Schmikli SL, Stubbe JH, Frederiks JE, Backx FJ. Effectiveness of an injury prevention programme for adult male amateur soccer players: a cluster-randomised controlled trial. British Journal of Sports Medicine. 46: 1114-8. PMID 22878257 DOI: 10.1136/bjsports-2012-091277  0.028
2005 Stubbe JH, Posthuma D, Boomsma DI, De Geus EJ. Heritability of life satisfaction in adults: a twin-family study. Psychological Medicine. 35: 1581-8. PMID 16219116 DOI: 10.1017/S0033291705005374  0.026
2010 Stubbe J. Universal monotonicity of eigenvalue moments and sharp Lieb-Thirring inequalities Journal of the European Mathematical Society. 12: 1347-1353. DOI: 10.4171/JEMS/233  0.026
2014 De Bruycker E, De Vroey S, Huysmans S, Stubbe J. Phenomenology of hydrogen flaking in nuclear reactor pressure vessels Materialpruefung/Materials Testing. 56: 439-444. DOI: 10.3139/120.110580  0.022
2006 Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ, Posthuma D, van Beijsterveldt TC, Hudziak JJ, Bartels M, Willemsen G. Netherlands Twin Register: from twins to twin families. Twin Research and Human Genetics : the Official Journal of the International Society For Twin Studies. 9: 849-57. PMID 17254420 DOI: 10.1375/183242706779462426  0.02
2007 Stubbe JH, de Moor MHM, Boomsma DI, de Geus EJC. The association between exercise participation and well-being: A co-twin study Preventive Medicine. 44: 148-152. PMID 17059845 DOI: 10.1016/j.ypmed.2006.09.002  0.018
2007 Stubbe JH, Gelsema T, Delnoij DMJ. The Consumer Quality Index Hip Knee Questionnaire measuring patients' experiences with quality of care after a total hip or knee arthroplasty Bmc Health Services Research. 7. PMID 17462084 DOI: 10.1186/1472-6963-7-60  0.018
2007 Stubbe JH, Brouwer W, Delnoij DMJ. Patients' experiences with quality of hospital care: The Consumer Quality Index Cataract Questionnaire Bmc Ophthalmology. 7. PMID 17877840 DOI: 10.1186/1471-2415-7-14  0.016
2010 De Geus EJC, Stubbe JH. Aerobic Exercise and Stress Reduction Encyclopedia of Stress. 73-78. DOI: 10.1016/B978-012373947-6.00014-3  0.016
2015 Stubbe JH, van Beijsterveldt AM, van der Knaap S, Stege J, Verhagen EA, van Mechelen W, Backx FJ. Injuries in professional male soccer players in the Netherlands: a prospective cohort study. Journal of Athletic Training. 50: 211-6. PMID 25531144 DOI: 10.4085/1062-6050-49.3.64  0.014
2006 De Moor MHM, Beem AL, Stubbe JH, Boomsma DI, De Geus EJC. Regular exercise, anxiety, depression and personality: A population-based study Preventive Medicine. 42: 273-279. PMID 16439008 DOI: 10.1016/j.ypmed.2005.12.002  0.013
2011 Prins JC, Stubbe JH, van Meeteren NL, Scheffers FA, van Dongen MC. Feasibility and preliminary effectiveness of ice therapy in patients with an acute tear in the gastrocnemius muscle: a pilot randomized controlled trial. Clinical Rehabilitation. 25: 433-41. PMID 21059665 DOI: 10.1177/0269215510388312  0.013
2003 Sawicki PT, Gläser B, Kleespies C, Stubbe J, Schmitz N, Kaiser T, Didjurgeit U. Self-management of oral anticoagulation: Long-term results [2] Journal of Internal Medicine. 254: 515-516. PMID 14535976 DOI: 10.1046/j.1365-2796.2003.01215.x  0.012
2007 Biollay Y, Chaabouni A, Stubbe J. Math part!: Basics and exercises for the first year of Engineering | Matematica si parte!:Nozioni di base ed esercizi per il primo anno di Ingegneria Unitext - La Matematica Per Il 3 Piu 2. 33.  0.012
2008 De Moor MH, Boomsma DI, Stubbe JH, Willemsen G, de Geus EJ. Testing causality in the association between regular exercise and symptoms of anxiety and depression. Archives of General Psychiatry. 65: 897-905. PMID 18678794 DOI: 10.1001/archpsyc.65.8.897  0.011
2003 Sawicki PT, Gläser B, Kleespies C, Stubbe J, Schmitz N, Kaiser T, Didjurgeit U. Long-Term Results of Patients' Self-Management of Oral Anticoagulation Journal of Clinical and Basic Cardiology. 6: 59-62.  0.011
2004 Vink JM, Willemsen G, Stubbe JH, Middeldorp CM, Ligthart RSL, Baas KD, Dirkzwager HJC, De Geus EJC, Boomsma DI. Estimating non-response bias in family studies: Application to mental health and lifestyle European Journal of Epidemiology. 19: 623-630. DOI: 10.1023/B:EJEP.0000036814.56108.66  0.01
2015 van Beijsterveldt AM, Thijs KM, Backx FJ, Steffen K, Brozi?evi? V, Stubbe JH. Sports injuries and illnesses during the European Youth Olympic Festival 2013. British Journal of Sports Medicine. 49: 448-52. PMID 25573616 DOI: 10.1136/bjsports-2014-094035  0.01
2015 van Beijsterveldt AM, Stubbe JH, Schmikli SL, van de Port IG, Backx FJ. Differences in injury risk and characteristics between Dutch amateur and professional soccer players. Journal of Science and Medicine in Sport / Sports Medicine Australia. 18: 145-9. PMID 24636127 DOI: 10.1016/j.jsams.2014.02.004  0.01
2015 Stubbe J. Comparative heuristics from an STS perspective. Inquiring "Novelty" in material practice Historical Social Research. 40: 109-129. DOI: 10.12759/hsr.40.2015.3.109-129  0.01
2014 van Beijsterveldt AM, Steffen K, Stubbe JH, Frederiks JE, van de Port IG, Backx FJ. Soccer injuries and recovery in Dutch male amateur soccer players: results of a prospective cohort study. Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine. 24: 337-42. PMID 24346734 DOI: 10.1097/JSM.0000000000000028  0.01
2013 Wang M, Jin W, Guo AM, Stubbe J. Cardiovascular inflammation. Mediators of Inflammation. 2013: 123513. PMID 23983400 DOI: 10.1155/2013/123513  0.01
2013 Stege JP, Fleuren MAH, Van Der Knaap ETW, Stubbe JH. Digital Sport Medical Record: Sigh or a blessing? | Het digitale sport medisch dossier: Zucht of zegen? Sport En Geneeskunde. 46: 16-23.  0.01
2009 Stubbe JH, De Geus EJC. Genetics of exercise behavior Handbook of Behavior Genetics. 343-358. DOI: 10.1007/978-0-387-76727-7_24  0.01
2009 Stubbe JW, Fockens P. Endoscopic Ultrasonography and Colonoscopy Colonoscopy: Principles and Practice, Second Edition. 501-513. DOI: 10.1002/9781444316902.ch37  0.01
2007 Choquard P, Stubbe J. The one-dimensional Schrödinger-Newton equations Letters in Mathematical Physics. 81: 177-184. DOI: 10.1007/s11005-007-0174-y  0.01
2006 Stubbe JH, Boomsma DI, Vink JM, Cornes BK, Martin NG, Skytthe A, Kyvik KO, Rose RJ, Kujala UM, Kaprio J, Harris JR, Pedersen NL, Hunkin J, Spector TD, de Geus EJC. Genetic influences on exercise participation in 37.051 twin pairs from seven countries Plos One. 1. PMID 17183649 DOI: 10.1371/Journal.Pone.0000022  0.01
2006 Stubbe J. The genetics of exercise behavior and psychological well-being | De erfelijkheid van sportgedrag en psychologisch welbevinden Geneeskunde En Sport. 39: 201-202.  0.01
2005 Stubbe JH, Boomsma DI, De Geus EJC. Sports participation during adolescence: A shift from environmental to genetic factors Medicine and Science in Sports and Exercise. 37: 563-570. PMID 15809553 DOI: 10.1249/01.MSS.0000158181.75442.8B  0.01
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