Eric N. Jacobsen - Publications

Affiliations: 
Chemistry and Chemical Biology Harvard University, Cambridge, MA, United States 
Area:
Mechanistic and synthetic chemistry
Website:
http://www.chem.harvard.edu/groups/Jacobsen/

173 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bendelsmith AJ, Kim SC, Wasa M, Roche SP, Jacobsen EN. Enantioselective Synthesis of α-Allyl Amino Esters via Hydrogen-Bond Donor Catalysis. Journal of the American Chemical Society. PMID 31280564 DOI: 10.1021/jacs.9b05556  0.88
2019 Haj MK, Banik SM, Jacobsen EN. Catalytic, Enantioselective 1,2-Difluorination of Cinnamamides. Organic Letters. PMID 30963766 DOI: 10.1021/acs.orglett.9b00938  0.48
2018 Zhou B, Haj MK, Jacobsen EN, Houk KN, Xue XS. Mechanism and Origins of Chemo- and Stereoselectivities of Aryl Iodide-Catalyzed Asymmetric Difluorinations of β-Substituted Styrenes. Journal of the American Chemical Society. PMID 30350956 DOI: 10.1021/jacs.8b05935  0.32
2018 Kwan EE, Zeng Y, Besser HA, Jacobsen EN. Concerted nucleophilic aromatic substitutions. Nature Chemistry. PMID 30013193 DOI: 10.1038/s41557-018-0079-7  0.52
2018 Wendlandt AE, Vangal P, Jacobsen EN. Quaternary stereocentres via an enantioconvergent catalytic S1 reaction. Nature. 556: 447-451. PMID 29695848 DOI: 10.1038/s41586-018-0042-1  0.8
2018 Mennie KM, Banik SM, Reichert EC, Jacobsen EN. Catalytic Diastereo- and Enantioselective Fluoroamination of Alkenes. Journal of the American Chemical Society. PMID 29583001 DOI: 10.1021/jacs.8b02143  0.48
2017 Banik SM, Levina A, Hyde AM, Jacobsen EN. Lewis acid enhancement by hydrogen-bond donors for asymmetric catalysis. Science (New York, N.Y.). 358: 761-764. PMID 29123063 DOI: 10.1126/science.aao5894  0.48
2017 Klausen RS, Kennedy CR, Hyde AM, Jacobsen EN. Chiral Thioureas Promote Enantioselective Pictet-Spengler Cyclization by Stabilizing Every Intermediate and Transition State in the Carboxylic Acid-Catalyzed Reaction. Journal of the American Chemical Society. PMID 28787140 DOI: 10.1021/jacs.7b06811  1
2017 Banik SM, Mennie K, Jacobsen EN. Catalytic 1,3-Difunctionalization via Oxidative C-C Bond Activation. Journal of the American Chemical Society. PMID 28622723 DOI: 10.1021/jacs.7b05160  0.48
2017 Park Y, Harper KC, Kuhl N, Kwan EE, Liu RY, Jacobsen EN. Macrocyclic bis-thioureas catalyze stereospecific glycosylation reactions. Science (New York, N.Y.). 355: 162-166. PMID 28082586 DOI: 10.1126/science.aal1875  0.88
2016 Kwan EE, Park Y, Besser HA, Anderson TL, Jacobsen EN. Sensitive and Accurate 13C Kinetic Isotope Effect Measurements Enabled by Polarization Transfer. Journal of the American Chemical Society. PMID 28005341 DOI: 10.1021/jacs.6b10621  0.72
2016 Park Y, Schindler CS, Jacobsen EN. Enantioselective Aza-Sakurai Cyclizations: Dual Role of Thiourea as H-bond Donor and Lewis Base. Journal of the American Chemical Society. PMID 27787993 DOI: 10.1021/jacs.6b09736  1
2016 Woerly E, Banik SM, Jacobsen EN. Enantioselective, Catalytic Fluorolactonization Reactions with a Nucleophilic Fluoride Source. Journal of the American Chemical Society. PMID 27709922 DOI: 10.1021/jacs.6b09499  0.48
2016 Kennedy CR, Lehnherr D, Rajapaksa NS, Ford DD, Park Y, Jacobsen EN. Mechanism-Guided Development of a Highly Active Bis-Thiourea Catalyst for Anion-Abstraction Catalysis. Journal of the American Chemical Society. 138: 13525–8. PMID 27704810 DOI: 10.1021/jacs.6b09205  1
2016 Kennedy CR, Guidera JA, Jacobsen EN. Synergistic Ion-Binding Catalysis Demonstrated via an Enantioselective, Catalytic [2,3]-Wittig Rearrangement. Acs Central Science. 2: 416-23. PMID 27413786 DOI: 10.1021/acscentsci.6b00125  0.68
2016 Banik SM, Medley JW, Jacobsen EN. Catalytic, asymmetric difluorination of alkenes to generate difluoromethylated stereocenters. Science (New York, N.Y.). 353: 51-4. PMID 27365443 DOI: 10.1126/science.aaf8078  1
2016 Kennedy CR, Lin S, Jacobsen EN. The Cation-π Interaction in Small-Molecule Catalysis. Angewandte Chemie (International Ed. in English). PMID 27329991 DOI: 10.1002/anie.201600547  1
2016 Lehnherr D, Ford DD, Bendelsmith AJ, Kennedy CR, Jacobsen EN. Conformational Control of Chiral Amido-Thiourea Catalysts Enables Improved Activity and Enantioselectivity. Organic Letters. 18: 3214-7. PMID 27294369 DOI: 10.1021/acs.orglett.6b01435  0.92
2016 Ford DD, Lehnherr D, Kennedy CR, Jacobsen EN. On- and Off-Cycle Catalyst Cooperativity in Anion-Binding Catalysis. Journal of the American Chemical Society. 138: 7860-3. PMID 27276389 DOI: 10.1021/jacs.6b04686  0.92
2016 Banik SM, Medley JW, Jacobsen EN. Catalytic, Diastereoselective 1,2-Difluorination of Alkenes. Journal of the American Chemical Society. PMID 27046019 DOI: 10.1021/jacs.6b02391  1
2016 Jacobsen EN. Advanced Synthesis & Catalysis after 15 Years: Challenges and New Opportunities for Synthetic Science Advanced Synthesis and Catalysis. 358: 2. DOI: 10.1002/adsc.201600013  1
2015 Turek AK, Hardee DJ, Ullman AM, Nocera DG, Jacobsen EN. Activation of Electron-Deficient Quinones through Hydrogen-Bond-Donor-Coupled Electron Transfer. Angewandte Chemie (International Ed. in English). PMID 26612607 DOI: 10.1002/anie.201508060  1
2015 Liu RY, Wasa M, Jacobsen EN. Enantioselective synthesis of tertiary α-chloro esters by non-covalent catalysis. Tetrahedron Letters. 56: 3428-3430. PMID 26085694 DOI: 10.1016/j.tetlet.2015.01.124  1
2015 Witten MR, Jacobsen EN. A Simple Primary Amine Catalyst for Enantioselective α-Hydroxylations and α-Fluorinations of Branched Aldehydes. Organic Letters. 17: 2772-5. PMID 25952578 DOI: 10.1021/acs.orglett.5b01193  1
2015 Jacobsen EN. Steve Buchwald @60 Advanced Synthesis and Catalysis. 357: 2173-2174. DOI: 10.1002/adsc.201500536  1
2014 Fang YQ, Tadross PM, Jacobsen EN. Highly enantioselective, intermolecular hydroamination of allenyl esters catalyzed by bifunctional phosphinothioureas. Journal of the American Chemical Society. 136: 17966-8. PMID 25496451 DOI: 10.1021/ja5117638  1
2014 Zhang H, Lin S, Jacobsen EN. Enantioselective selenocyclization via dynamic kinetic resolution of seleniranium ions by hydrogen-bond donor catalysts. Journal of the American Chemical Society. 136: 16485-8. PMID 25380129 DOI: 10.1021/ja510113s  1
2014 Bess EN, Bischoff AJ, Sigman MS. Designer substrate library for quantitative, predictive modeling of reaction performance. Proceedings of the National Academy of Sciences of the United States of America. 111: 14698-703. PMID 25267648 DOI: 10.1073/pnas.1409522111  1
2014 Yeung CS, Ziegler RE, Porco JA, Jacobsen EN. Thiourea-catalyzed enantioselective addition of indoles to pyrones: alkaloid cores with quaternary carbons. Journal of the American Chemical Society. 136: 13614-7. PMID 25213353 DOI: 10.1021/ja508523g  1
2014 Wasa M, Liu RY, Roche SP, Jacobsen EN. Asymmetric Mannich synthesis of α-amino esters by anion-binding catalysis. Journal of the American Chemical Society. 136: 12872-5. PMID 25178040 DOI: 10.1021/ja5075163  0.88
2014 White DE, Tadross PM, Lu Z, Jacobsen EN. A broadly applicable and practical oligomeric (salen) Co catalyst for enantioselective epoxide ring-opening reactions. Tetrahedron. 70: 4165-4180. PMID 25045188 DOI: 10.1016/j.tet.2014.03.043  1
2014 Xu H, Zhang H, Jacobsen EN. Chiral sulfinamidourea and strong Brønsted acid-cocatalyzed enantioselective Povarov reaction to access tetrahydroquinolines. Nature Protocols. 9: 1860-6. PMID 25010906 DOI: 10.1038/nprot.2014.125  1
2014 Witten MR, Jacobsen EN. Catalytic asymmetric synthesis of 8-oxabicyclooctanes by intermolecular [5+2] pyrylium cycloadditions. Angewandte Chemie (International Ed. in English). 53: 5912-6. PMID 24782332 DOI: 10.1002/anie.201402834  1
2014 Bergonzini G, Schindler CS, Wallentin CJ, Jacobsen EN, Stephenson CR. Photoredox Activation and Anion Binding Catalysis in the Dual Catalytic Enantioselective Synthesis of β-Amino Esters. Chemical Science (Royal Society of Chemistry : 2010). 5. PMID 24294480 DOI: 10.1039/C3SC52265B  1
2013 Brindle CS, Yeung CS, Jacobsen EN. Chiral β-Iodoamines by Urea-Catalyzed Iodocyclization of Trichloroacetimidates. Chemical Sciences Journal. 4. PMID 24416631 DOI: 10.1039/C3SC50410G  1
2013 Ford DD, Nielsen LP, Zuend SJ, Musgrave CB, Jacobsen EN. Mechanistic basis for high stereoselectivity and broad substrate scope in the (salen)Co(III)-catalyzed hydrolytic kinetic resolution. Journal of the American Chemical Society. 135: 15595-608. PMID 24041239 DOI: 10.1021/ja408027p  1
2013 Rajapaksa NS, Jacobsen EN. Enantioselective catalytic transannular ketone-ene reactions. Organic Letters. 15: 4238-41. PMID 23923982 DOI: 10.1021/ol401968m  1
2013 Birrell JA, Jacobsen EN. A practical method for the synthesis of highly enantioenriched trans-1,2-amino alcohols. Organic Letters. 15: 2895-7. PMID 23742206 DOI: 10.1021/ol401013s  1
2013 Schindler CS, Jacobsen EN. Chemistry. A new twist on cooperative catalysis. Science (New York, N.Y.). 340: 1052-3. PMID 23723222 DOI: 10.1126/science.1238769  1
2013 Brown AR, Uyeda C, Brotherton CA, Jacobsen EN. Enantioselective thiourea-catalyzed intramolecular cope-type hydroamination. Journal of the American Chemical Society. 135: 6747-9. PMID 23597402 DOI: 10.1021/ja402893z  1
2013 Rajapaksa NS, McGowan MA, Rienzo M, Jacobsen EN. Enantioselective total synthesis of (+)-reserpine. Organic Letters. 15: 706-9. PMID 23331099 DOI: 10.1021/ol400046n  1
2013 Lalonde MP, McGowan MA, Rajapaksa NS, Jacobsen EN. Enantioselective formal aza-Diels-Alder reactions of enones with cyclic imines catalyzed by primary aminothioureas. Journal of the American Chemical Society. 135: 1891-4. PMID 23321009 DOI: 10.1021/ja310718f  1
2013 Brak K, Jacobsen EN. Asymmetric ion-pairing catalysis. Angewandte Chemie (International Ed. in English). 52: 534-61. PMID 23192886 DOI: 10.1002/anie.201205449  1
2012 Tadross PM, Jacobsen EN. Site-selective reactions: Remodelling by diversity and design. Nature Chemistry. 4: 963-5. PMID 23174971 DOI: 10.1038/nchem.1509  1
2012 Gerard B, O'Shea MW, Donckele E, Kesavan S, Akella LB, Xu H, Jacobsen EN, Marcaurelle LA. Application of a catalytic asymmetric Povarov reaction using chiral ureas to the synthesis of a tetrahydroquinoline library. Acs Combinatorial Science. 14: 621-30. PMID 23088641 DOI: 10.1021/co300098v  1
2012 Lin S, Jacobsen EN. Thiourea-catalysed ring opening of episulfonium ions with indole derivatives by means of stabilizing non-covalent interactions. Nature Chemistry. 4: 817-24. PMID 23000995 DOI: 10.1038/nchem.1450  1
2012 Burns NZ, Jacobsen EN. Organic chemistry: catalysis in tight spaces. Nature. 483: 278-9. PMID 22422255 DOI: 10.1038/483278a  1
2012 Nielsen LP, Zuend SJ, Ford DD, Jacobsen EN. Mechanistic basis for high reactivity of (salen)Co-OTs in the hydrolytic kinetic resolution of terminal epoxides. The Journal of Organic Chemistry. 77: 2486-95. PMID 22292515 DOI: 10.1021/jo300181f  1
2011 Lee Y, Klausen RS, Jacobsen EN. Thiourea-catalyzed enantioselective iso-Pictet-Spengler reactions. Organic Letters. 13: 5564-7. PMID 21919478 DOI: 10.1021/ol202300t  1
2011 Burns NZ, Witten MR, Jacobsen EN. Dual catalysis in enantioselective oxidopyrylium-based [5 + 2] cycloadditions. Journal of the American Chemical Society. 133: 14578-81. PMID 21848300 DOI: 10.1021/ja206997e  1
2011 Birrell JA, Desrosiers JN, Jacobsen EN. Enantioselective acylation of silyl ketene acetals through fluoride anion-binding catalysis. Journal of the American Chemical Society. 133: 13872-5. PMID 21800916 DOI: 10.1021/ja205602j  1
2011 Beck EM, Hyde AM, Jacobsen EN. Chiral sulfinamide/achiral sulfonic acid cocatalyzed enantioselective protonation of enol silanes. Organic Letters. 13: 4260-3. PMID 21786775 DOI: 10.1021/ol201608a  1
2011 Uyeda C, Jacobsen EN. Transition-state charge stabilization through multiple non-covalent interactions in the guanidinium-catalyzed enantioselective Claisen rearrangement. Journal of the American Chemical Society. 133: 5062-75. PMID 21391614 DOI: 10.1021/ja110842s  1
2010 Jacobsen EN, MacMillan DW. Organocatalysis. Proceedings of the National Academy of Sciences of the United States of America. 107: 20618-9. PMID 21119011 DOI: 10.1073/pnas.1016087107  1
2010 Uyeda C, Rötheli AR, Jacobsen EN. Catalytic enantioselective claisen rearrangements of O-allyl β-ketoesters. Angewandte Chemie (International Ed. in English). 49: 9753-6. PMID 21080393 DOI: 10.1002/anie.201005183  1
2010 Knowles RR, Jacobsen EN. Attractive noncovalent interactions in asymmetric catalysis: links between enzymes and small molecule catalysts. Proceedings of the National Academy of Sciences of the United States of America. 107: 20678-85. PMID 20956302 DOI: 10.1073/pnas.1006402107  1
2010 Veitch GE, Jacobsen EN. Tertiary aminourea-catalyzed enantioselective iodolactonization. Angewandte Chemie (International Ed. in English). 49: 7332-5. PMID 20803601 DOI: 10.1002/anie.201003681  1
2010 McGowan MA, Stevenson CP, Schiffler MA, Jacobsen EN. An enantioselective total synthesis of (+)-peloruside A. Angewandte Chemie (International Ed. in English). 49: 6147-50. PMID 20586089 DOI: 10.1002/anie.201002177  1
2010 Brown AR, Kuo WH, Jacobsen EN. Enantioselective catalytic alpha-alkylation of aldehydes via an SN1 pathway. Journal of the American Chemical Society. 132: 9286-8. PMID 20568761 DOI: 10.1021/ja103618r  1
2010 Knowles RR, Lin S, Jacobsen EN. Enantioselective thiourea-catalyzed cationic polycyclizations. Journal of the American Chemical Society. 132: 5030-2. PMID 20369901 DOI: 10.1021/ja101256v  1
2010 Xu H, Zuend SJ, Woll MG, Tao Y, Jacobsen EN. Asymmetric cooperative catalysis of strong Brønsted acid-promoted reactions using chiral ureas. Science (New York, N.Y.). 327: 986-90. PMID 20167783 DOI: 10.1126/science.1182826  1
2009 Zuend SJ, Coughlin MP, Lalonde MP, Jacobsen EN. Scaleable catalytic asymmetric Strecker syntheses of unnatural alpha-amino acids. Nature. 461: 968-70. PMID 19829379 DOI: 10.1038/nature08484  1
2009 Zuend SJ, Jacobsen EN. Mechanism of amido-thiourea catalyzed enantioselective imine hydrocyanation: transition state stabilization via multiple non-covalent interactions. Journal of the American Chemical Society. 131: 15358-74. PMID 19778044 DOI: 10.1021/ja9058958  1
2009 Peterson EA, Jacobsen EN. Enantioselective, thiourea-catalyzed intermolecular addition of indoles to cyclic N-acyl iminium ions. Angewandte Chemie (International Ed. in English). 48: 6328-31. PMID 19610008 DOI: 10.1002/anie.200902420  1
2009 Loy RN, Jacobsen EN. Enantioselective intramolecular openings of oxetanes catalyzed by (salen)Co(III) complexes: access to enantioenriched tetrahydrofurans. Journal of the American Chemical Society. 131: 2786-7. PMID 19199427 DOI: 10.1021/ja809176m  1
2009 Klausen RS, Jacobsen EN. Weak Brønsted acid-thiourea co-catalysis: enantioselective, catalytic protio-Pictet-Spengler reactions. Organic Letters. 11: 887-90. PMID 19178157 DOI: 10.1021/ol802887h  1
2009 Mita T, Jacobsen EN. Bifunctional asymmetric catalysis with hydrogen chloride: Enantioselective ring opening of aziridines catalyzed by a phosphinothiourea Synlett. 1680-1684. DOI: 10.1055/s-0029-1217344  1
2008 Groll M, Balskus EP, Jacobsen EN. Structural analysis of spiro beta-lactone proteasome inhibitors. Journal of the American Chemical Society. 130: 14981-3. PMID 18928262 DOI: 10.1021/ja806059t  1
2008 Watson MP, Jacobsen EN. Asymmetric intramolecular arylcyanation of unactivated olefins via C-CN bond activation. Journal of the American Chemical Society. 130: 12594-5. PMID 18761453 DOI: 10.1021/ja805094j  1
2008 Uyeda C, Jacobsen EN. Enantioselective Claisen rearrangements with a hydrogen-bond donor catalyst. Journal of the American Chemical Society. 130: 9228-9. PMID 18576616 DOI: 10.1021/ja803370x  1
2008 Reisman SE, Doyle AG, Jacobsen EN. Enantioselective thiourea-catalyzed additions to oxocarbenium ions. Journal of the American Chemical Society. 130: 7198-9. PMID 18479086 DOI: 10.1021/ja801514m  1
2008 Fang YQ, Jacobsen EN. Cooperative, highly enantioselective phosphinothiourea catalysis of imine-allene [3 + 2] cycloadditions. Journal of the American Chemical Society. 130: 5660-1. PMID 18393504 DOI: 10.1021/ja801344w  1
2008 Raheem IT, Thiara PS, Jacobsen EN. Regio- and enantioselective catalytic cyclization of pyrroles onto N-acyliminium ions. Organic Letters. 10: 1577-80. PMID 18341346 DOI: 10.1021/ol800256j  1
2008 Mergott DJ, Zuend SJ, Jacobsen EN. Catalytic asymmetric total synthesis of (+)-yohimbine. Organic Letters. 10: 745-8. PMID 18257582 DOI: 10.1021/ol702781q  1
2008 Mazet C, Jacobsen EN. Dinuclear {(salen)Al} complexes display expanded scope in the conjugate cyanation of alpha,beta-unsaturated imides. Angewandte Chemie (International Ed. in English). 47: 1762-5. PMID 18219639 DOI: 10.1002/anie.200704461  1
2008 Grachan ML, Tudge MT, Jacobsen EN. Enantioselective catalytic carbonyl-ene cyclization reactions. Angewandte Chemie (International Ed. in English). 47: 1469-72. PMID 18188857 DOI: 10.1002/anie.200704439  1
2007 Doyle AG, Jacobsen EN. Small-molecule H-bond donors in asymmetric catalysis. Chemical Reviews. 107: 5713-43. PMID 18072808 DOI: 10.1021/cr068373r  1
2007 Zuend SJ, Jacobsen EN. Cooperative catalysis by tertiary amino-thioureas: mechanism and basis for enantioselectivity of ketone cyanosilylation. Journal of the American Chemical Society. 129: 15872-83. PMID 18052247 DOI: 10.1021/ja0735352  1
2007 Raheem IT, Thiara PS, Peterson EA, Jacobsen EN. Enantioselective Pictet-Spengler-type cyclizations of hydroxylactams: H-bond donor catalysis by anion binding. Journal of the American Chemical Society. 129: 13404-5. PMID 17941641 DOI: 10.1021/ja076179w  1
2007 Balskus EP, Jacobsen EN. Asymmetric catalysis of the transannular Diels-Alder reaction. Science (New York, N.Y.). 317: 1736-40. PMID 17885133 DOI: 10.1126/science.1146939  1
2007 Doyle AG, Jacobsen EN. Enantioselective alkylation of acyclic alpha,alpha-disubstituted tributyltin enolates catalyzed by a {Cr(salen)} complex. Angewandte Chemie (International Ed. in English). 46: 3701-5. PMID 17407117 DOI: 10.1002/anie.200604901  1
2007 Tan KL, Jacobsen EN. Indium-mediated asymmetric allylation of acylhydrazones using a chiral urea catalyst. Angewandte Chemie (International Ed. in English). 46: 1315-7. PMID 17211916 DOI: 10.1002/anie.200603354  1
2006 Lalonde MP, Chen Y, Jacobsen EN. A chiral primary amine thiourea catalyst for the highly enantioselective direct conjugate addition of alpha,alpha-disubstituted aldehydes to nitroalkenes. Angewandte Chemie (International Ed. in English). 45: 6366-70. PMID 16937417 DOI: 10.1002/anie.200602221  1
2006 Huang H, Jacobsen EN. Highly enantioselective direct conjugate addition of ketones to nitroalkenes promoted by a chiral primary amine-thiourea catalyst. Journal of the American Chemical Society. 128: 7170-1. PMID 16734464 DOI: 10.1021/ja0620890  1
2006 Balskus EP, Jacobsen EN. Alpha,beta-unsaturated beta-silyl imide substrates for catalytic, enantioselective conjugate additions: a total synthesis of (+)-lactacystin and the discovery of a new proteasome inhibitor. Journal of the American Chemical Society. 128: 6810-2. PMID 16719460 DOI: 10.1021/ja061970a  1
2006 Taylor MS, Jacobsen EN. Asymmetric catalysis by chiral hydrogen-bond donors. Angewandte Chemie (International Ed. in English). 45: 1520-43. PMID 16491487 DOI: 10.1002/anie.200503132  1
2006 Nielsen LPC, Jacobsen EN. Catalytic Asymmetric Epoxide Ring-opening Chemistry Aziridines and Epoxides in Organic Synthesis. 229-269. DOI: 10.1002/3527607862.ch7  1
2006 Stevenson CP, Nielsen LPC, Jacobsen EN. Preparation of (S)-methyl glycidate via hydrolytic kinetic resolution Organic Syntheses. 83: 162-169.  1
2005 Taylor MS, Tokunaga N, Jacobsen EN. Enantioselective thiourea-catalyzed acyl-mannich reactions of isoquinolines. Angewandte Chemie (International Ed. in English). 44: 6700-4. PMID 16175644 DOI: 10.1002/anie.200502277  1
2005 Jarvo ER, Lawrence BM, Jacobsen EN. Highly enantio- and regioselective quinone Diels-Alder reactions catalyzed by a tridentate [(Schiff Base)Cr(III)] complex. Angewandte Chemie (International Ed. in English). 44: 6043-6. PMID 16134190 DOI: 10.1002/anie.200502176  1
2005 Boezio AA, Jarvo ER, Lawrence BM, Jacobsen EN. Efficient total syntheses of (-)-colombiasin A and (-)-elisapterosin B: application of the Cr-catalyzed asymmetric quinone Diels-Alder reaction. Angewandte Chemie (International Ed. in English). 44: 6046-50. PMID 16108082 DOI: 10.1002/anie.200502178  1
2005 Fuerst DE, Jacobsen EN. Thiourea-catalyzed enantioselective cyanosilylation of ketones. Journal of the American Chemical Society. 127: 8964-5. PMID 15969569 DOI: 10.1021/ja052511x  1
2005 Gandelman M, Jacobsen EN. Highly enantioselective catalytic conjugate addition of N-heterocycles to alpha,beta-unsaturated ketones and imides. Angewandte Chemie (International Ed. in English). 44: 2393-7. PMID 15761885 DOI: 10.1002/anie.200463058  1
2005 Taylor MS, Zalatan DN, Lerchner AM, Jacobsen EN. Highly enantioselective conjugate additions to alpha,beta-unsaturated ketones catalyzed by a (salen)Al complex. Journal of the American Chemical Society. 127: 1313-7. PMID 15669872 DOI: 10.1021/ja044999s  1
2005 Doyle AG, Jacobsen EN. Enantioselective alkylations of tributyltin enolates catalyzed by Cr(salen)Cl: access to enantiomerically enriched all-carbon quaternary centers. Journal of the American Chemical Society. 127: 62-3. PMID 15631449 DOI: 10.1021/ja043601p  1
2005 Yoon TP, Jacobsen EN. Highly enantioselective thiourea-catalyzed nitro-Mannich reactions. Angewandte Chemie (International Ed. in English). 44: 466-8. PMID 15624148 DOI: 10.1002/anie.200461814  1
2005 Jacobsen EN, Pfaltz A, Shibasaki M. Catalytic C-C bond formation Advanced Synthesis and Catalysis. 347: 1471. DOI: 10.1002/adsc.200505313  1
2005 Raheem IT, Jacobsen EN. Highly enantioselective aza-Baylis-Hillman reactions catalyzed by chiral thiourea derivatives Advanced Synthesis and Catalysis. 347: 1701-1708. DOI: 10.1002/adsc.200505230  1
2005 Wenzel AG, Jacobsen EN. Asymmetric Catalysis in Enantioselective Synthesis of β-Amino Acids Enantioselective Synthesis of β-Amino Acids: Second Edition. 107-115. DOI: 10.1002/0471698482.ch4  1
2005 Chavez DE, Jacobsen EN. An efficient, highly diastereo- and enantioselective hetero-Diels-Alder catalyst. Preparation of (2S,6R)-6-(tert-butyldimethyl-silyloxymethyl)-2- methoxy-2,5-dihydropyran Organic Syntheses. 82: 34-42.  1
2004 Vanderwal CD, Jacobsen EN. Enantioselective formal hydration of alpha,beta-unsaturated imides by Al-catalyzed conjugate addition of oxime nucleophiles. Journal of the American Chemical Society. 126: 14724-5. PMID 15535689 DOI: 10.1021/ja045563f  1
2004 Taylor MS, Jacobsen EN. Highly enantioselective catalytic acyl-pictet-spengler reactions. Journal of the American Chemical Society. 126: 10558-9. PMID 15327311 DOI: 10.1021/ja046259p  1
2004 Sammis GM, Danjo H, Jacobsen EN. Cooperative dual catalysis: application to the highly enantioselective conjugate cyanation of unsaturated imides. Journal of the American Chemical Society. 126: 9928-9. PMID 15303860 DOI: 10.1021/ja046653n  1
2004 Kim SK, Jacobsen EN. General catalytic synthesis of highly enantiomerically enriched terminal aziridines from racemic epoxides. Angewandte Chemie (International Ed. in English). 43: 3952-4. PMID 15274223 DOI: 10.1002/anie.200460369  1
2004 Joly GD, Jacobsen EN. Thiourea-catalyzed enantioselective hydrophosphonylation of imines: practical access to enantiomerically enriched alpha-amino phosphonic acids. Journal of the American Chemical Society. 126: 4102-3. PMID 15053588 DOI: 10.1021/ja0494398  1
2004 Taylor MS, Jacobsen EN. Asymmetric catalysis in complex target synthesis. Proceedings of the National Academy of Sciences of the United States of America. 101: 5368-73. PMID 15020767 DOI: 10.1073/pnas.0307893101  1
2004 Nielsen LP, Stevenson CP, Blackmond DG, Jacobsen EN. Mechanistic investigation leads to a synthetic improvement in the hydrolytic kinetic resolution of terminal epoxides. Journal of the American Chemical Society. 126: 1360-2. PMID 14759192 DOI: 10.1021/ja038590z  1
2004 Raheem IT, Goodman SN, Jacobsen EN. Catalytic asymmetric total syntheses of quinine and quinidine. Journal of the American Chemical Society. 126: 706-7. PMID 14733531 DOI: 10.1021/ja039550y  1
2004 Keith JM, Jacobsen EN. Asymmetric hydrocyanation of hydrazones catalyzed by lanthanide--PYBOX complexes. Organic Letters. 6: 153-5. PMID 14723516 DOI: 10.1021/ol035844c  1
2004 Jacobsen EN. Oxidation catalysis: Bringing together the interests of academic and industrial researchers Advanced Synthesis and Catalysis. 346: 109.  1
2003 Taylor MS, Jacobsen EN. Enantioselective Michael additions to alpha,beta-unsaturated imides catalyzed by a Salen-Al complex. Journal of the American Chemical Society. 125: 11204-5. PMID 16220935 DOI: 10.1021/ja037177o  1
2003 Ruck RT, Jacobsen EN. Asymmetric hetero-ene reactions of trimethylsilyl enol ethers catalyzed by tridentate Schiff base chromium(III) complexes. Angewandte Chemie (International Ed. in English). 42: 4771-4. PMID 14562344 DOI: 10.1002/anie.200351591  1
2003 Chavez DE, Jacobsen EN. Catalyst-controlled inverse-electron-demand hetero-Diels-Alder reactions in the enantio- and diastereoselective synthesis of iridoid natural products. Organic Letters. 5: 2563-5. PMID 12841781 DOI: 10.1021/ol034883l  1
2003 Sammis GM, Jacobsen EN. Highly enantioselective, catalytic conjugate addition of cyanide to alpha,beta-unsaturated imides. Journal of the American Chemical Society. 125: 4442-3. PMID 12683813 DOI: 10.1021/ja034635k  1
2003 Yoon TP, Jacobsen EN. Privileged chiral catalysts. Science (New York, N.Y.). 299: 1691-3. PMID 12637734 DOI: 10.1126/science.1083622  1
2003 White DE, Jacobsen EN. New oligomeric catalyst for the hydrolytic kinetic resolution of terminal epoxides under solvent-free conditions Tetrahedron Asymmetry. 14: 3633-3638. DOI: 10.1016/j.tetasy.2003.09.024  1
2003 Wenzel AG, Lalonde MP, Jacobsen EN. Divergent Stereoinduction Mechanisms in Urea-Catalyzed Additions to Imines Synlett. 1919-1922.  1
2002 Ready JM, Jacobsen EN. A practical oligomeric [(salen)Co] catalyst for asymmetric epoxide ring-opening reactions. Angewandte Chemie (International Ed. in English). 41: 1374-7. PMID 19750769 DOI: 10.1002/1521-3773(20020415)41:8<1374::AID-ANIE1374>3.0.CO;2-8  1
2002 Goodman SN, Jacobsen EN. Enantiopure beta-hydroxy morpholine amides from terminal epoxides by carbonylation at 1 atm. Angewandte Chemie (International Ed. in English). 41: 4703-5. PMID 12481332 DOI: 10.1002/anie.200290022  1
2002 Movassaghi M, Jacobsen EN. Chemistry. The simplest "enzyme". Science (New York, N.Y.). 298: 1904-5. PMID 12471240 DOI: 10.1126/science.1076547  1
2002 Wenzel AG, Jacobsen EN. Asymmetric catalytic Mannich reactions catalyzed by urea derivatives: enantioselective synthesis of beta-aryl-beta-amino acids. Journal of the American Chemical Society. 124: 12964-5. PMID 12405820 DOI: 10.1021/ja028353g  1
2002 Gademann K, Chavez DE, Jacobsen EN. Highly enantioselective inverse-electron-demand hetero-diels-alder reactions of alpha,beta-unsaturated aldehydes. Angewandte Chemie (International Ed. in English). 41: 3059-61. PMID 12203458 DOI: 10.1002/1521-3773(20020816)41:16<3059::AID-ANIE3059>3.0.CO;2-I  1
2002 Vachal P, Jacobsen EN. Structure-based analysis and optimization of a highly enantioselective catalyst for the strecker reaction. Journal of the American Chemical Society. 124: 10012-4. PMID 12188665 DOI: 10.1021/ja027246j  1
2002 Joly GD, Jacobsen EN. Catalyst-controlled diastereoselective hetero-Diels-Alder reactions. Organic Letters. 4: 1795-8. PMID 12000301 DOI: 10.1021/ol0258785  1
2002 Ruck RT, Jacobsen EN. Asymmetric catalysis of hetero-ene reactions with tridentate Schiff base chromium(III) complexes. Journal of the American Chemical Society. 124: 2882-3. PMID 11902873 DOI: 10.1021/ja025588j  1
2002 Movassaghi M, Jacobsen EN. A direct method for the conversion of terminal epoxides into gamma-butanolides. Journal of the American Chemical Society. 124: 2456-7. PMID 11890792  1
2002 Schaus SE, Brandes BD, Larrow JF, Tokunaga M, Hansen KB, Gould AE, Furrow ME, Jacobsen EN. Highly selective hydrolytic kinetic resolution of terminal epoxides catalyzed by chiral (salen)Co(III) complexes. Practical synthesis of enantioenriched terminal epoxides and 1,2-diols. Journal of the American Chemical Society. 124: 1307-15. PMID 11841300 DOI: 10.1021/ja016737l  1
2002 Movassaghi M, Jacobsen EN. A direct method for the conversion of terminal epoxides into γ-butanolides Journal of the American Chemical Society. 124: 2456-2457. DOI: 10.1021/ja025604c  1
2002 Goodman SN, Jacobsen EN. A Practical Synthesis of α,β-Unsaturated Imides, Useful Substrates for Asymmetric Conjugate Addition Reactions Advanced Synthesis and Catalysis. 344: 953-956. DOI: 10.1002/1615-4169(200210)344:9<953::AID-ADSC953>3.0.CO;2-A  1
2001 Liu P, Jacobsen EN. Total synthesis of (+)-ambruticin. Journal of the American Chemical Society. 123: 10772-3. PMID 11674024 DOI: 10.1021/ja016893s  1
2001 Thompson CF, Jamison TF, Jacobsen EN. FR901464: total synthesis, proof of structure, and evaluation of synthetic analogues. Journal of the American Chemical Society. 123: 9974-83. PMID 11592876 DOI: 10.1021/ja016615t  1
2001 Chavez DE, Jacobsen EN. Total Synthesis of Fostriecin (CI-920) We thank Professor Andrew G. Myers and Scott E. Schaus for helpful discussions, and Dr. Alexandra E. Gould and Isabel K. Reichardt for important preliminary experimental work. We also thank Dr. Robert J. Schultz of the Drug Synthesis and Chemistry Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer institute, for a sample of natural fostriecin. This work was supported by the NIH (GM-59316), and by Beinecke Memorial and NSF predoctoral fellowships to D.E.C. Angewandte Chemie (International Ed. in English). 40: 3667-3670. PMID 11592216 DOI: 10.1002/1521-3773(20011001)40:19<3667::AID-ANIE3667>3.0.CO;2-6  1
2001 White MC, Doyle AG, Jacobsen EN. A synthetically useful, self-assembling MMO mimic system for catalytic alkene epoxidation with aqueous H2O2. Journal of the American Chemical Society. 123: 7194-5. PMID 11459514 DOI: 10.1021/ja015884g  1
2001 Ready JM, Jacobsen EN. Highly active oligomeric (salen)co catalysts for asymmetric epoxide ring-opening reactions. Journal of the American Chemical Society. 123: 2687-8. PMID 11456948 DOI: 10.1021/ja005867b  1
2001 Brandes BD, Jacobsen EN. Regioselective ring opening of enantiomerically enriched epoxides via catalysis with chiral (salen)Cr(III) complexes Synlett. 1013-1015.  1
2001 Su JT, Vachal P, Jacobsen EN. Practical Synthesis of a Soluble Schiff Base Catalyst for the Asymmetric Strecker Reaction Advanced Synthesis and Catalysis. 343: 197-200.  1
2001 Keith JM, Larrow JF, Jacobsen EN. Practical Considerations in Kinetic Resolution Reactions Advanced Synthesis and Catalysis. 343: 5-26.  1
2000 Breinbauer R, Jacobsen EN. Cooperative Asymmetric Catalysis with Dendrimeric Angewandte Chemie (International Ed. in English). 39: 3604-3607. PMID 11091412 DOI: 10.1002/1521-3773(20001016)39:20<3604::AID-ANIE3604>3.0.CO;2-9  1
2000 Jacobsen EN. Asymmetric catalysis of epoxide ring-opening reactions. Accounts of Chemical Research. 33: 421-31. PMID 10891060 DOI: 10.1021/ar960061v  1
2000 Schaus SE, Jacobsen EN. Asymmetric ring opening of meso epoxides with TMSCN catalyzed by (pybox)lanthanide complexes. Organic Letters. 2: 1001-4. PMID 10768207  1
2000 Sigman MS, Vachal P, Jacobsen EN. A General Catalyst for the Asymmetric Strecker Reaction This work was supported by the NIH (GM-43214). A postdoctoral fellowship to M.S.S. (NIH), and a predoctoral fellowship to P.V. sponsored by Alfred Bader are gratefully acknowledged. Angewandte Chemie (International Ed. in English). 39: 1279-1281. PMID 10767031 DOI: 10.1002/(SICI)1521-3773(20000403)39:7<1279::AID-ANIE1279>3.0.CO;2-U  1
2000 Vachal P, Jacobsen EN. Enantioselective catalytic addition of HCN to ketoimines. Catalytic synthesis of quaternary amino acids. Organic Letters. 2: 867-70. PMID 10754690  1
2000 Jacobsen EN, Breinbauer R. Nickel comes full cycle Science. 287: 437-438. DOI: 10.1126/science.287.5452.437  1
2000 Thompson CF, Jamison TF, Jacobsen EN. Total synthesis of FR901464. Convergent assembly of chiral components prepared by asymmetric catalysis [17] Journal of the American Chemical Society. 122: 10482-10483. DOI: 10.1021/ja0055357  1
2000 Foote CS, Jacobsen EN. Catalytic asymmetric synthesis special issue: Editorial Accounts of Chemical Research. 33: 323. DOI: 10.1021/ar0000455  1
1999 Francis MB, Jacobsen EN. Discovery of Novel Catalysts for Alkene Epoxidation from Metal-Binding Combinatorial Libraries. Angewandte Chemie (International Ed. in English). 38: 937-941. PMID 29711875 DOI: 10.1002/(SICI)1521-3773(19990401)38:7<937::AID-ANIE937>3.0.CO;2-O  1
1999 Li Z, Fernández M, Jacobsen EN. Enantioselective ring opening of meso aziridines catalyzed by Tridentate Schiff base chromium(III) complexes. Organic Letters. 1: 1611-3. PMID 10836024  1
1999 Peukert S, Jacobsen EN. Enantioselective parallel synthesis using polymer-supported chiral Co(salen) complexes. Organic Letters. 1: 1245-8. PMID 10825975  1
1999 Dossetter AG, Jamison TF, Jacobsen EN. Highly Enantio- and Diastereoselective Hetero-Diels-Alder Reactions Catalyzed by New Chiral Tridentate Chromium(III) Catalysts. Angewandte Chemie (International Ed. in English). 38: 2398-2400. PMID 10458800 DOI: 10.1002/(SICI)1521-3773(19990816)38:16<2398::AID-ANIE2398>3.0.CO;2-E  1
1999 Hinterding K, Jacobsen EN. Regioselective carbomethoxylation of chiral epoxides: A new route to enantiomerically pure β-hydroxy esters Journal of Organic Chemistry. 64: 2164-2165. DOI: 10.1021/jo982336l  1
1999 Myers JK, Jacobsen EN. Asymmetric synthesis of β-amino acid derivatives via catalytic conjugate addition of hydrazoic acid to unsaturated imides [10] Journal of the American Chemical Society. 121: 8959-8960. DOI: 10.1021/ja991621z  1
1999 Ready JM, Jacobsen EN. Asymmetric catalytic synthesis of α-aryloxy alcohols: Kinetic resolution of terminal epoxides via highly enantioselective ring-opening with phenols Journal of the American Chemical Society. 121: 6086-6087. DOI: 10.1021/ja9910917  1
1999 Annis DA, Jacobsen EN. Polymer-supported chiral Co(salen) complexes: Synthetic applications and mechanistic investigations in the hydrolytic kinetic resolution of terminal epoxides Journal of the American Chemical Society. 121: 4147-4154. DOI: 10.1021/ja984410n  1
1999 Lebel H, Jacobsen EN. Chromium catalyzed kinetic resolution of 2,2-disubstituted epoxides Tetrahedron Letters. 40: 7303-7306. DOI: 10.1016/S0040-4039(99)01502-6  1
1999 Francis MB, Jacobsen EN. Discovery of novel catalysts for alkene epoxidation from metal-binding combinatorial libraries Angewandte Chemie - International Edition. 38: 937-941. DOI: 10.1002/(SICI)1521-3773(19990401)38:7<937::AID-ANIE937>3.0.CO;2-O  1
1999 Larrow JF, Roberts E, Verhoeven TR, Ryan KM, Senanayake CH, Reider PJ, Jacobsen EN. (1S,2R)-1-aminoindan-2-OL Organic Syntheses. 76: 46-55.  1
1999 Wu MH, Hansen KB, Jacobsen EN. Regio- and enantioselective cyclization of epoxy alcohols catalyzed by a [Co(III)(salen)] complex Angewandte Chemie - International Edition. 38: 2012-2014.  1
1998 Furrow ME, Schaus SE, Jacobsen EN. Practical Access to Highly Enantioenriched C-3 Building Blocks via Hydrolytic Kinetic Resolution. The Journal of Organic Chemistry. 63: 6776-6777. PMID 11672291  1
1998 Francis MB, Jamison TF, Jacobsen EN. Combinatorial libraries of transition-metal complexes, catalysts and materials. Current Opinion in Chemical Biology. 2: 422-8. PMID 9691076  1
1998 Lebel H, Jacobsen EN. Enantioselective total synthesis of taurospongin A Journal of Organic Chemistry. 63: 9624-9625. DOI: 10.1021/jo9819741  1
1998 Schaus SE, Brånalt J, Jacobsen EN. Total synthesis of muconin by efficient assembly of chiral building blocks Journal of Organic Chemistry. 63: 4876-4877. DOI: 10.1021/jo9810765  1
1998 Konsler RG, Karl J, Jacobsen EN. Cooperative asymmetric catalysis with dimeric salen complexes [11] Journal of the American Chemical Society. 120: 10780-10781. DOI: 10.1021/ja982683c  1
1998 Sigman MS, Jacobsen EN. Enantioselective addition of hydrogen cyanide to imines catalyzed by a chiral (salen)Al(III) complex [1] Journal of the American Chemical Society. 120: 5315-5316. DOI: 10.1021/ja980299+  1
1998 Sigman MS, Jacobsen EN. Schiff base catalysts for the asymmetric strecker reaction identified and optimized from parallel synthetic libraries Journal of the American Chemical Society. 120: 4901-4902. DOI: 10.1021/ja980139y  1
1998 Palucki M, Finney NS, Pospisil PJ, Güler ML, Ishida T, Jacobsen EN. The mechanistic basis for electronic effects on enantioselectivity in the (salen)Mn(III)-catalyzed epoxidation reaction Journal of the American Chemical Society. 120: 948-954. DOI: 10.1021/ja973468j  1
1998 Dakin LA, Schaus SE, Jacobsen EN, Panek JS. Carbenoid insertions into the silicon-hydrogen bond catalyzed by chiral copper (I) Schiff base complexes Tetrahedron Letters. 39: 8947-8950.  1
1998 Larrow JF, Jacobsen EN. (R,R)-N,N'-bis(3,5-Di-tert-butylsalicylidene)-1,2-cyclohexanediamino manganese(III) chloride, a highly enantioselective epoxidation catalyst: (Manganese, chloro[[2,2'-[1,2-cyclohexanediylbis(nitrilomethylidyne)]-bis[4,6-bis(1,1- dimethylethyl)phenalato]](2-)-N,N',O,O']-, [SP-5-13-(1R-trans-]-) Organic Syntheses. 75: 1-10.  1
1998 Annis DA, Helluin O, Jacobsen EN. Stereochemistry as a diversity element: Solid-phase synthesis of cyclic RGD peptide derivatives by asymmetric catalysis Angewandte Chemie - International Edition. 37: 1907-1909.  1
1998 Zamojski A, Jacobsen EN, Kakiuchi F, Konsler RG, Larrow JF, Tokunaga M. Enantioselective catalytic ring opening of epoxides with carboxylic acids Chemtracts. 11: 287-290.  0.64
1997 Tokunaga M, Larrow JF, Kakiuchi F, Jacobsen EN. Asymmetric catalysis with water: efficient kinetic resolution of terminal epoxides by means of catalytic hydrolysis. Science (New York, N.Y.). 277: 936-8. PMID 9252321 DOI: 10.1126/science.277.5328.936  1
1997 Brandes BD, Jacobsen EN. Synthesis of enantiopure 3-chlorostyrene oxide via an asymmetric epoxidation-hydrolytic kinetic resolution sequence Tetrahedron Asymmetry. 8: 3927-3933. DOI: 10.1016/S0957-4166(97)00568-5  1
1997 Wu MH, Jacobsen EN. An efficient formal synthesis of balanol via the asymmetric epoxide ring opening reaction Tetrahedron Letters. 38: 1693-1696. DOI: 10.1016/S0040-4039(97)00192-5  1
1994 Jacobsen EN, Finney NS. Synthetic and biological catalysts in chemical synthesis: how to assess practical utility. Chemistry & Biology. 1: 85-90. PMID 9383375 DOI: 10.1016/1074-5521(94)90045-0  1
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