Daniel E. Kahne - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
molecular mechanisms of various antibiotics
Website:
http://www.chem.harvard.edu/groups/kahne/index.html

125 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Taguchi A, Welsh MA, Marmont LS, Lee W, Sjodt M, Kruse AC, Kahne D, Bernhardt TG, Walker S. FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein. Nature Microbiology. PMID 30692671 DOI: 10.1038/s41564-018-0345-x  0.96
2018 Rohs PDA, Buss J, Sim SI, Squyres GR, Srisuknimit V, Smith M, Cho H, Sjodt M, Kruse AC, Garner EC, Walker S, Kahne DE, Bernhardt TG. A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery. Plos Genetics. 14: e1007726. PMID 30335755 DOI: 10.1371/journal.pgen.1007726  0.96
2018 Buss JA, Baidin V, Welsh MA, Flores-Kim J, Cho H, Wood BM, Uehara T, Walker S, Kahne D, Bernhardt TG. A pathway-directed screen for inhibitors of the bacterial cell elongation machinery. Antimicrobial Agents and Chemotherapy. PMID 30323039 DOI: 10.1128/AAC.01530-18  0.96
2018 Sjodt M, Brock K, Dobihal G, Rohs PDA, Green AG, Hopf TA, Meeske AJ, Srisuknimit V, Kahne D, Walker S, Marks DS, Bernhardt TG, Rudner DZ, Kruse AC. Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis. Nature. PMID 29590088 DOI: 10.1038/nature25985  0.96
2018 Rubino FA, Kumar S, Ruiz N, Walker S, Kahne D. Membrane potential is required for MurJ function. Journal of the American Chemical Society. PMID 29558128 DOI: 10.1021/jacs.8b00942  0.96
2018 Lee W, Do T, Zhang G, Kahne D, Meredith TC, Walker S. Antibiotic combinations that enable one-step, targeted mutagenesis of chromosomal genes. Acs Infectious Diseases. PMID 29534563 DOI: 10.1021/acsinfecdis.8b00017  0.96
2018 Schaefer K, Owens TW, Kahne D, Walker S. Substrate preferences establish the order of cell wall assembly in Staphylococcus aureus. Journal of the American Chemical Society. PMID 29402087 DOI: 10.1021/jacs.7b13551  0.96
2017 Welsh MA, Taguchi A, Schaefer K, Van Tyne D, Lebreton F, Gilmore MS, Kahne D, Walker S. Identification of a Functionally Unique Family of Penicillin-Binding Proteins. Journal of the American Chemical Society. PMID 29182854 DOI: 10.1021/jacs.7b10170  0.96
2017 Konovalova A, Kahne DE, Silhavy TJ. Outer Membrane Biogenesis. Annual Review of Microbiology. 71: 539-556. PMID 28886680 DOI: 10.1146/annurev-micro-090816-093754  0.64
2017 Srisuknimit V, Qiao Y, Schaefer K, Kahne D, Walker S. Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections. Journal of the American Chemical Society. PMID 28691491 DOI: 10.1021/jacs.7b04881  0.96
2017 Qiao Y, Srisuknimit V, Rubino F, Schaefer K, Ruiz N, Walker S, Kahne D. Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams. Nature Chemical Biology. PMID 28553948 DOI: 10.1038/nchembio.2388  0.96
2017 Wzorek JS, Lee J, Tomasek D, Hagan CL, Kahne DE. Membrane integration of an essential β-barrel protein prerequires burial of an extracellular loop. Proceedings of the National Academy of Sciences of the United States of America. PMID 28223520 DOI: 10.1073/pnas.1616576114  0.8
2017 Schaefer K, Matano LM, Qiao Y, Kahne D, Walker S. In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins. Nature Chemical Biology. PMID 28166208 DOI: 10.1038/nchembio.2302  0.96
2016 Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ. SEDS proteins are a widespread family of bacterial cell wall polymerases. Nature. PMID 27525505 DOI: 10.1038/nature19331  1
2016 Lee J, Xue M, Wzorek JS, Wu T, Grabowicz M, Gronenberg LS, Sutterlin HA, Davis RM, Ruiz N, Silhavy TJ, Kahne DE. Characterization of a stalled complex on the β-barrel assembly machine. Proceedings of the National Academy of Sciences of the United States of America. PMID 27439868 DOI: 10.1073/pnas.1604100113  1
2016 Markovski M, Bohrhunter JL, Lupoli TJ, Uehara T, Walker S, Kahne DE, Bernhardt TG. Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27071112 DOI: 10.1073/pnas.1524538113  1
2015 Lee W, Schaefer K, Qiao Y, Srisuknimit V, Steinmetz H, Müller R, Kahne D, Walker S. The mechanism of action of lysobactin. Journal of the American Chemical Society. PMID 26683668 DOI: 10.1021/jacs.5b11807  1
2015 Simpson BW, May JM, Sherman DJ, Kahne D, Ruiz N. Lipopolysaccharide transport to the cell surface: biosynthesis and extraction from the inner membrane. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 370. PMID 26370941 DOI: 10.1098/rstb.2015.0029  1
2015 May JM, Sherman DJ, Simpson BW, Ruiz N, Kahne D. Lipopolysaccharide transport to the cell surface: periplasmic transport and assembly into the outer membrane. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 370. PMID 26370939 DOI: 10.1098/rstb.2015.0027  1
2015 Hagan CL, Wzorek JS, Kahne D. Inhibition of the β-barrel assembly machine by a peptide that binds BamD. Proceedings of the National Academy of Sciences of the United States of America. 112: 2011-6. PMID 25646443 DOI: 10.1073/pnas.1415955112  1
2014 Qiao Y, Lebar MD, Schirner K, Schaefer K, Tsukamoto H, Kahne D, Walker S. Detection of lipid-linked peptidoglycan precursors by exploiting an unexpected transpeptidase reaction. Journal of the American Chemical Society. 136: 14678-81. PMID 25291014 DOI: 10.1021/ja508147s  0.96
2014 Lebar MD, May JM, Meeske AJ, Leiman SA, Lupoli TJ, Tsukamoto H, Losick R, Rudner DZ, Walker S, Kahne D. Reconstitution of peptidoglycan cross-linking leads to improved fluorescent probes of cell wall synthesis. Journal of the American Chemical Society. 136: 10874-7. PMID 25036369 DOI: 10.1021/ja505668f  0.96
2014 Sham LT, Butler EK, Lebar MD, Kahne D, Bernhardt TG, Ruiz N. MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis Science. 345: 220-222. PMID 25013077 DOI: 10.1126/science.1254522  1
2014 Malojčić G, Andres D, Grabowicz M, George AH, Ruiz N, Silhavy TJ, Kahne D. LptE binds to and alters the physical state of LPS to catalyze its assembly at the cell surface. Proceedings of the National Academy of Sciences of the United States of America. 111: 9467-72. PMID 24938785 DOI: 10.1073/pnas.1402746111  1
2014 Sherman DJ, Lazarus MB, Murphy L, Liu C, Walker S, Ruiz N, Kahne D. Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport. Proceedings of the National Academy of Sciences of the United States of America. 111: 4982-7. PMID 24639492 DOI: 10.1073/pnas.1323516111  0.96
2014 Lupoli TJ, Lebar MD, Markovski M, Bernhardt T, Kahne D, Walker S. Lipoprotein activators stimulate escherichia coli penicillin-binding proteins by different mechanisms Journal of the American Chemical Society. 136: 52-55. PMID 24341982 DOI: 10.1021/ja410813j  1
2014 Rebets Y, Lupoli T, Qiao Y, Schirner K, Villet R, Hooper D, Kahne D, Walker S. Moenomycin resistance mutations in Staphylococcus aureus reduce peptidoglycan chain length and cause aberrant cell division. Acs Chemical Biology. 9: 459-67. PMID 24255971 DOI: 10.1021/cb4006744  1
2014 Qiao Y, Lebar MD, Schirner K, Schaefer K, Tsukamoto H, Kahne D, Walker S. Detection of lipid-linked peptidoglycan precursors by exploiting an unexpected transpeptidase reaction Journal of the American Chemical Society. 136: 14678-14681. DOI: 10.1021/ja508147s  1
2014 Lebar MD, May JM, Meeske AJ, Leiman SA, Lupoli TJ, Tsukamoto H, Losick R, Rudner DZ, Walker S, Kahne D. Reconstitution of peptidoglycan cross-linking leads to improved fluorescent probes of cell wall synthesis Journal of the American Chemical Society. 136: 10874-10877. DOI: 10.1021/ja505668f  1
2013 Zhang G, Meredith TC, Kahne D. On the essentiality of lipopolysaccharide to Gram-negative bacteria. Current Opinion in Microbiology. 16: 779-85. PMID 24148302 DOI: 10.1016/j.mib.2013.09.007  1
2013 Leiman SA, May JM, Lebar MD, Kahne D, Kolter R, Losick R. D-amino acids indirectly inhibit biofilm formation in Bacillus subtilis by interfering with protein synthesis. Journal of Bacteriology. 195: 5391-5. PMID 24097941 DOI: 10.1128/JB.00975-13  1
2013 Hagan CL, Westwood DB, Kahne D. bam Lipoproteins Assemble BamA in vitro. Biochemistry. 52: 6108-13. PMID 23919461 DOI: 10.1021/bi400865z  1
2013 Sherman DJ, Okuda S, Denny WA, Kahne D. Validation of inhibitors of an ABC transporter required to transport lipopolysaccharide to the cell surface in Escherichia coli. Bioorganic & Medicinal Chemistry. 21: 4846-51. PMID 23665139 DOI: 10.1016/j.bmc.2013.04.020  1
2013 Lebar MD, Lupoli TJ, Tsukamoto H, May JM, Walker S, Kahne D. Forming cross-linked peptidoglycan from synthetic gram-negative lipid II Journal of the American Chemical Society. 135: 4632-4635. PMID 23480167 DOI: 10.1021/ja312510m  1
2013 Gampe CM, Tsukamoto H, Doud EH, Walker S, Kahne D. Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors. Journal of the American Chemical Society. 135: 3776-9. PMID 23448584 DOI: 10.1021/ja4000933  1
2013 Villa R, Martorana AM, Okuda S, Gourlay LJ, Nardini M, Sperandeo P, Dehò G, Bolognesi M, Kahne D, Polissi A. The Escherichia coli Lpt transenvelope protein complex for lipopolysaccharide export is assembled via conserved structurally homologous domains. Journal of Bacteriology. 195: 1100-8. PMID 23292770 DOI: 10.1128/JB.02057-12  1
2012 Okuda S, Freinkman E, Kahne D. Cytoplasmic ATP hydrolysis powers transport of lipopolysaccharide across the periplasm in E. coli. Science (New York, N.Y.). 338: 1214-7. PMID 23138981 DOI: 10.1126/science.1228984  1
2012 Yao Z, Kahne D, Kishony R. Distinct single-cell morphological dynamics under beta-lactam antibiotics. Molecular Cell. 48: 705-12. PMID 23103254 DOI: 10.1016/j.molcel.2012.09.016  1
2012 Chng SS, Xue M, Garner RA, Kadokura H, Boyd D, Beckwith J, Kahne D. Disulfide rearrangement triggered by translocon assembly controls lipopolysaccharide export. Science (New York, N.Y.). 337: 1665-8. PMID 22936569 DOI: 10.1126/science.1227215  1
2012 Yao Z, Davis RM, Kishony R, Kahne D, Ruiz N. Regulation of cell size in response to nutrient availability by fatty acid biosynthesis in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 109: E2561-8. PMID 22908292 DOI: 10.1073/pnas.1209742109  1
2012 Freinkman E, Okuda S, Ruiz N, Kahne D. Regulated assembly of the transenvelope protein complex required for lipopolysaccharide export. Biochemistry. 51: 4800-6. PMID 22668317 DOI: 10.1021/bi300592c  1
2012 Ricci DP, Hagan CL, Kahne D, Silhavy TJ. Activation of the Escherichia coli β-barrel assembly machine (Bam) is required for essential components to interact properly with substrate Proceedings of the National Academy of Sciences of the United States of America. 109: 3487-3491. PMID 22331884 DOI: 10.1073/pnas.1201362109  1
2011 Gampe CM, Tsukamoto H, Wang TS, Walker S, Kahne D. Modular synthesis of diphospholipid oligosaccharide fragments of the bacterial cell wall and their use to study the mechanism of moenomycin and other antibiotics. Tetrahedron. 67: 9771-9778. PMID 22505780 DOI: 10.1016/j.tet.2011.09.114  1
2011 Oman TJ, Lupoli TJ, Wang TSA, Kahne D, Walker S, Van Der Donk WA. Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry Journal of the American Chemical Society. 133: 17544-17547. PMID 22003874 DOI: 10.1021/ja206281k  1
2011 Hagan CL, Kahne D. The reconstituted Escherichia coli Bam complex catalyzes multiple rounds of β-barrel assembly. Biochemistry. 50: 7444-6. PMID 21823654 DOI: 10.1021/bi2010784  1
2011 Lupoli TJ, Tsukamoto H, Doud EH, Wang TS, Walker S, Kahne D. Transpeptidase-mediated incorporation of D-amino acids into bacterial peptidoglycan. Journal of the American Chemical Society. 133: 10748-51. PMID 21682301 DOI: 10.1021/ja2040656  1
2011 Tsukamoto H, Kahne D. N-Methylimidazolium chloride-catalyzed pyrophosphate formation: Application to the synthesis of Lipid i and NDP-sugar donors Bioorganic and Medicinal Chemistry Letters. 21: 5050-5053. PMID 21592792 DOI: 10.1016/j.bmcl.2011.04.061  1
2011 Wang TS, Lupoli TJ, Sumida Y, Tsukamoto H, Wu Y, Rebets Y, Kahne DE, Walker S. Primer preactivation of peptidoglycan polymerases. Journal of the American Chemical Society. 133: 8528-30. PMID 21568328 DOI: 10.1021/ja2028712  1
2011 Zhang W, Ntai I, Bolla ML, Malcolmson SJ, Kahne D, Kelleher NL, Walsh CT. Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics. Journal of the American Chemical Society. 133: 5240-3. PMID 21417270 DOI: 10.1021/ja2011109  1
2011 Hagan CL, Silhavy TJ, Kahne D. β-barrel membrane protein assembly by the bam complex Annual Review of Biochemistry. 80: 189-210. PMID 21370981 DOI: 10.1146/annurev-biochem-061408-144611  1
2011 Chimalakonda G, Ruiz N, Chng SS, Garner RA, Kahne D, Silhavy TJ. Lipoprotein LptE is required for the assembly of LptD by the beta-barrel assembly machine in the outer membrane of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 108: 2492-7. PMID 21257909 DOI: 10.1073/pnas.1019089108  1
2011 Freinkman E, Chng SS, Kahne D. The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel. Proceedings of the National Academy of Sciences of the United States of America. 108: 2486-91. PMID 21257904 DOI: 10.1073/pnas.1015617108  1
2010 Paradis-Bleau C, Markovski M, Uehara T, Lupoli TJ, Walker S, Kahne DE, Bernhardt TG. Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases. Cell. 143: 1110-20. PMID 21183074 DOI: 10.1016/j.cell.2010.11.037  1
2010 Ruiz N, Chng SS, Hinikera A, Kahne D, Silhavy TJ. Nonconsecutive disulfide bond formation in an essential integral outer membrane protein Proceedings of the National Academy of Sciences of the United States of America. 107: 12245-12250. PMID 20566849 DOI: 10.1073/pnas.1007319107  1
2010 Fuse S, Tsukamoto H, Yuan Y, Wang TS, Zhang Y, Bolla M, Walker S, Sliz P, Kahne D. Functional and structural analysis of a key region of the cell wall inhibitor moenomycin. Acs Chemical Biology. 5: 701-11. PMID 20496948 DOI: 10.1021/cb100048q  1
2010 Silhavy TJ, Kahne D, Walker S. The bacterial cell envelope. Cold Spring Harbor Perspectives in Biology. 2: a000414. PMID 20452953 DOI: 10.1101/cshperspect.a000414  1
2010 Chng SS, Gronenberg LS, Kahne D. Proteins required for lipopolysaccharide assembly in Escherichia coli form a transenvelope complex. Biochemistry. 49: 4565-7. PMID 20446753 DOI: 10.1021/bi100493e  1
2010 Zhang W, Bolla ML, Kahne D, Walsh CT. A three enzyme pathway for 2-amino-3-hydroxycyclopent-2-enone formation and incorporation in natural product biosynthesis. Journal of the American Chemical Society. 132: 6402-11. PMID 20394362 DOI: 10.1021/ja1002845  1
2010 Hagan CL, Kim S, Kahne D. Reconstitution of outer membrane protein assembly from purified components. Science (New York, N.Y.). 328: 890-2. PMID 20378773 DOI: 10.1126/science.1188919  1
2010 Chng SS, Ruiz N, Chimalakonda G, Silhavy TJ, Kahne D. Characterization of the two-protein complex in Escherichia coli responsible for lipopolysaccharide assembly at the outer membrane. Proceedings of the National Academy of Sciences of the United States of America. 107: 5363-8. PMID 20203010 DOI: 10.1073/pnas.0912872107  1
2010 Gronenberg LS, Kahne D. Development of an activity assay for discovery of inhibitors of lipopolysaccharide transport. Journal of the American Chemical Society. 132: 2518-9. PMID 20136079 DOI: 10.1021/ja910361r  1
2010 Perlstein DL, Wang TS, Doud EH, Kahne D, Walker S. The role of the substrate lipid in processive glycan polymerization by the peptidoglycan glycosyltransferases. Journal of the American Chemical Society. 132: 48-9. PMID 20017480 DOI: 10.1021/ja909325m  1
2010 Sakurai K, Kahne D. Design and synthesis of functionalized trisaccharides as p53-peptide mimics Tetrahedron Letters. 51: 3724-3727. DOI: 10.1016/j.tetlet.2010.05.012  1
2009 Lupoli TJ, Taniguchi T, Wang TS, Perlstein DL, Walker S, Kahne DE. Studying a cell division amidase using defined peptidoglycan substrates. Journal of the American Chemical Society. 131: 18230-1. PMID 19957935 DOI: 10.1021/ja908916z  1
2009 Ostash B, Doud EH, Lin C, Ostash I, Perlstein DL, Fuse S, Wolpert M, Kahne D, Walker S. Complete characterization of the seventeen step moenomycin biosynthetic pathway. Biochemistry. 48: 8830-41. PMID 19640006 DOI: 10.1021/bi901018q  1
2009 Ruiz N, Kahne D, Silhavy TJ. Transport of lipopolysaccharide across the cell envelope: The long road of discovery Nature Reviews Microbiology. 7: 677-683. PMID 19633680 DOI: 10.1038/nrmicro2184  1
2009 Tanikawa T, Fridman M, Zhu W, Faulk B, Joseph IC, Kahne D, Wagner BK, Clemons PA. Using biological performance similarity to inform disaccharide library design. Journal of the American Chemical Society. 131: 5075-83. PMID 19298063 DOI: 10.1021/ja806583y  1
2008 Hu Y, Al-Mestarihi A, Grimes CL, Kahne D, Bachmann BO. A unifying nitrososynthase involved in nitrosugar biosynthesis. Journal of the American Chemical Society. 130: 15756-7. PMID 18983146 DOI: 10.1021/ja8051415  1
2008 Wang TS, Manning SA, Walker S, Kahne D. Isolated peptidoglycan glycosyltransferases from different organisms produce different glycan chain lengths. Journal of the American Chemical Society. 130: 14068-9. PMID 18834124 DOI: 10.1021/ja806016y  1
2008 Yuan Y, Fuse S, Ostash B, Sliz P, Kahne D, Walker S. Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design. Acs Chemical Biology. 3: 429-36. PMID 18642800 DOI: 10.1021/cb800078a  1
2008 Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ. Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 105: 5537-42. PMID 18375759 DOI: 10.1073/pnas.0801196105  1
2007 Perlstein DL, Zhang Y, Wang TS, Kahne DE, Walker S. The direction of glycan chain elongation by peptidoglycan glycosyltransferases. Journal of the American Chemical Society. 129: 12674-5. PMID 17914829 DOI: 10.1021/ja075965y  1
2007 Sklar JG, Wu T, Kahne D, Silhavy TJ. Defining the roles of the periplasmic chaperones SurA, Skp, and DegP in Escherichia coli Genes and Development. 21: 2473-2484. PMID 17908933 DOI: 10.1101/gad.1581007  1
2007 Barrett D, Wang TS, Yuan Y, Zhang Y, Kahne D, Walker S. Analysis of glycan polymers produced by peptidoglycan glycosyltransferases. The Journal of Biological Chemistry. 282: 31964-71. PMID 17704540 DOI: 10.1074/jbc.M705440200  1
2007 Kim S, Malinverni JC, Sliz P, Silhavy TJ, Harrison SC, Kahne D. Structure and function of an essential component of the outer membrane protein assembly machine. Science (New York, N.Y.). 317: 961-4. PMID 17702946 DOI: 10.1126/science.1143993  1
2007 Leimkuhler C, Fridman M, Lupoli T, Walker S, Walsh CT, Kahne D. Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A. Journal of the American Chemical Society. 129: 10546-50. PMID 17685523 DOI: 10.1021/ja072909o  1
2007 Howard-Jones AR, Kruger RG, Lu W, Tao J, Leimkuhler C, Kahne D, Walsh CT. Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin. Journal of the American Chemical Society. 129: 10082-3. PMID 17661468 DOI: 10.1021/ja0735857  1
2007 Fridman M, Balibar CJ, Lupoli T, Kahne D, Walsh CT, Garneau-Tsodikova S. Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7. Biochemistry. 46: 8462-71. PMID 17580964 DOI: 10.1021/bi700433v  1
2007 Sklar JG, Wu T, Gronenberg LS, Malinverni JC, Kahne D, Silhavy TJ. Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 104: 6400-5. PMID 17404237 DOI: 10.1073/pnas.0701579104  1
2007 Yuan Y, Barrett D, Zhang Y, Kahne D, Sliz P, Walker S. Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 5348-53. PMID 17360321 DOI: 10.1073/pnas.0701160104  1
2007 Zhang Y, Fechter EJ, Wang TS, Barrett D, Walker S, Kahne DE. Synthesis of heptaprenyl-lipid IV to analyze peptidoglycan glycosyltransferases. Journal of the American Chemical Society. 129: 3080-1. PMID 17323951 DOI: 10.1021/ja069060g  1
2006 Ruiz N, Wu T, Kahne D, Silhavy TJ. Probing the barrier function of the outer membrane with chemical conditionality. Acs Chemical Biology. 1: 385-395. PMID 17163776 DOI: 10.1021/cb600128v  1
2006 Taylor JG, Li X, Oberthür M, Zhu W, Kahne DE. The total synthesis of moenomycin A. Journal of the American Chemical Society. 128: 15084-5. PMID 17117848 DOI: 10.1021/ja065907x  1
2006 Adachi M, Zhang Y, Leimkuhler C, Sun B, LaTour JV, Kahne DE. Degradation and reconstruction of moenomycin A and derivatives: dissecting the function of the isoprenoid chain. Journal of the American Chemical Society. 128: 14012-3. PMID 17061868 DOI: 10.1021/ja065905c  1
2006 Sakurai K, Schubert C, Kahne D. Crystallographic analysis of an 8-mer p53 peptide analogue complexed with MDM2 Journal of the American Chemical Society. 128: 11000-11001. PMID 16925398 DOI: 10.1021/ja063102j  1
2006 Wu T, McCandlish AC, Gronenberg LS, Chng SS, Silhavy TJ, Kahne D. Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 103: 11754-9. PMID 16861298 DOI: 10.1073/pnas.0604744103  1
2006 Garneau-Tsodikova S, Stapon A, Kahne D, Walsh CT. Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1. Biochemistry. 45: 8568-78. PMID 16834331 DOI: 10.1021/bi060784e  1
2006 Malinverni JC, Werner J, Kim S, Sklar JG, Kahne D, Misra R, Silhavy TJ. YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli Molecular Microbiology. 61: 151-164. PMID 16824102 DOI: 10.1111/j.1365-2958.2006.05211.x  1
2006 Silhavy TJ, Ruiz N, Kahne D. Advances in understanding bacterial outer-membrane biogenesis Nature Reviews Microbiology. 4: 57-66. PMID 16357861 DOI: 10.1038/nrmicro1322  1
2006 Ngundi MM, Taitt CR, McMurry SA, Kahne D, Ligler FS. Detection of bacterial toxins with monosaccharide arrays. Biosensors & Bioelectronics. 21: 1195-201. PMID 15946840 DOI: 10.1016/j.bios.2005.05.001  1
2005 Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S. In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides. Journal of the American Chemical Society. 127: 14128-9. PMID 16218575 DOI: 10.1021/ja053704n  1
2005 Oberthür M, Leimkuhler C, Kruger RG, Lu W, Walsh CT, Kahne D. A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases. Journal of the American Chemical Society. 127: 10747-52. PMID 16045364 DOI: 10.1021/ja052945s  1
2005 Lu W, Leimkuhler C, Gatto GJ, Kruger RG, Oberthür M, Kahne D, Walsh CT. AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A. Chemistry & Biology. 12: 527-34. PMID 15911373 DOI: 10.1016/j.chembiol.2005.02.016  1
2005 Ruiz N, Falcone B, Kahne D, Silhavy TJ. Chemical conditionality: A genetic strategy to probe organelle assembly Cell. 121: 307-317. PMID 15851036 DOI: 10.1016/j.cell.2005.02.014  1
2005 Wu T, Malinverni J, Ruiz N, Kim S, Silhavy TJ, Kahne D. Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli Cell. 121: 235-245. PMID 15851030 DOI: 10.1016/j.cell.2005.02.015  1
2005 Pacholec M, Freel Meyers CL, Oberthür M, Kahne D, Walsh CT. Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway. Biochemistry. 44: 4949-56. PMID 15779922 DOI: 10.1021/bi047303g  1
2005 Leimkuhler C, Chen L, Barrett D, Panzone G, Sun B, Falcone B, Oberthür M, Donadio S, Walker S, Kahne D. Differential inhibition of Staphylococcus aureus PBP2 by glycopeptide antibiotics. Journal of the American Chemical Society. 127: 3250-1. PMID 15755121 DOI: 10.1021/ja043849e  1
2005 Barrett D, Leimkuhler C, Chen L, Walker D, Kahne D, Walker S. Kinetic characterization of the glycosyltransferase module of Staphylococcus aureus PBP2. Journal of Bacteriology. 187: 2215-7. PMID 15743972 DOI: 10.1128/JB.187.6.2215-2217.2005  1
2005 Kahne D, Leimkuhler C, Lu W, Walsh C. Glycopeptide and lipoglycopeptide antibiotics Chemical Reviews. 105: 425-448. PMID 15700951 DOI: 10.1021/cr030103a  1
2005 Kruger RG, Lu W, Oberthür M, Tao J, Kahne D, Walsh CT. Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons. Chemistry & Biology. 12: 131-40. PMID 15664522 DOI: 10.1016/j.chembiol.2004.12.005  1
2005 Kagan E, Ragupathi G, Yi SS, Reis CA, Gildersleeve J, Kahne D, Clausen H, Danishefsky SJ, Livingston PO. Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn. Cancer Immunology, Immunotherapy : Cii. 54: 424-30. PMID 15625606 DOI: 10.1007/s00262-004-0584-y  1
2005 Leimkuhler C, Chen Z, Kruger RG, Oberthür M, Lu W, Walsh CT, Kahne D. Glycosylation of glycopeptides: A comparison of chemoenzymatic and chemical methods Tetrahedron Asymmetry. 16: 599-603. DOI: 10.1016/j.tetasy.2004.12.006  1
2004 Sakurai K, Hak SC, Kahne D. Use of a retroinverso p53 peptide as an inhibitor of MDM2 Journal of the American Chemical Society. 126: 16288-16289. PMID 15600307 DOI: 10.1021/ja044883w  1
2004 Freel Meyers CL, Oberthür M, Heide L, Kahne D, Walsh CT. Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN. Biochemistry. 43: 15022-36. PMID 15554710 DOI: 10.1021/bi048457z  1
2004 Oberthür M, Leimkuhler C, Kahne D. A practical method for the stereoselective generation of β-2-deoxy glycosyl phosphates Organic Letters. 6: 2873-2876. PMID 15330636 DOI: 10.1021/ol049187f  1
2004 Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S. Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway. Journal of the American Chemical Society. 126: 9924-5. PMID 15303858 DOI: 10.1021/ja048836f  1
2004 Lu W, Leimkuhler C, Oberthür M, Kahne D, Walsh CT. AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A. Biochemistry. 43: 4548-58. PMID 15078101 DOI: 10.1021/bi035945i  1
2004 Lu W, Oberthür M, Leimkuhler C, Tao J, Kahne D, Walsh CT. Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin. Proceedings of the National Academy of Sciences of the United States of America. 101: 4390-5. PMID 15070728 DOI: 10.1073/pnas.0400277101  1
2004 Howorka S, Nam J, Bayley H, Kahne D. Stochastic detection of monovalent and bivalent protein-ligand interactions. Angewandte Chemie (International Ed. in English). 43: 842-6. PMID 14767954 DOI: 10.1002/anie.200352614  1
2004 Meyers CLF, Oberthür M, Xu H, Heide L, Kahne D, Walsh CT. Characterization of NovP and NovN: Completion of Novobiocin Biosynthesis by Sequential Tailoring of the Noviosyl Ring Angewandte Chemie - International Edition. 43: 67-70. PMID 14694473 DOI: 10.1002/anie.200352626  1
2003 Basu A, Kahne D. Overcoming degeneracy in carbohydrate recognition. Angewandte Chemie (International Ed. in English). 42: 2504-6. PMID 12800171 DOI: 10.1002/anie.200250859  1
2003 Chen L, Walker D, Sun B, Hu Y, Walker S, Kahne D. Vancomycin analogues active against vanA-resistant strains inhibit bacterial transglycosylase without binding substrate. Proceedings of the National Academy of Sciences of the United States of America. 100: 5658-63. PMID 12714684 DOI: 10.1073/pnas.0931492100  1
2003 Meyers CLF, Oberthür M, Anderson JW, Kahne D, Walsh CT. Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin Biochemistry. 42: 4179-4189. PMID 12680772 DOI: 10.1021/bi0340088  1
2002 Losey HC, Jiang J, Biggins JB, Oberthür M, Ye XY, Dong SD, Kahne D, Thorson JS, Walsh CT. Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides. Chemistry & Biology. 9: 1305-14. PMID 12498883 DOI: 10.1016/S1074-5521(02)00270-3  1
2002 Dong SD, Oberthür M, Losey HC, Anderson JW, Eggert US, Peczuh MW, Walsh CT, Kahne D. The structural basis for induction of VanB resistance. Journal of the American Chemical Society. 124: 9064-5. PMID 12149006 DOI: 10.1021/ja026342h  1
2002 Chen Z, Eggert US, Dong SD, Shaw SJ, Sun B, LaTour JV, Kahne D. Structural requirements for vanA activity of vancomycin analogues Tetrahedron. 58: 6585-6594. DOI: 10.1016/S0040-4020(02)00743-3  1
2001 Sun B, Chen Z, Eggert US, Shaw SJ, LaTour JV, Kahne D. Hybrid glycopeptide antibiotics. Journal of the American Chemical Society. 123: 12722-3. PMID 11741455 DOI: 10.1021/ja0166693  1
2001 Eggert US, Ruiz N, Falcone BV, Branstrom AA, Goldman RC, Silhavy TJ, Kahne D. Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin Science. 294: 361-364. PMID 11520949 DOI: 10.1126/science.1063611  1
2001 Ye XY, Lo MC, Brunner L, Walker D, Kahne D, Walker S. Better substrates for bacterial transglycosylases. Journal of the American Chemical Society. 123: 3155-6. PMID 11457035 DOI: 10.1021/ja010028q  1
1997 Bowe CL, Mokhtarzadeh L, Venkatesan P, Babu S, Axelrod HR, Sofia MJ, Kakarla R, Chan TY, Kim JS, Lee HJ, Amidon GL, Choe SY, Walker S, Kahne D. Design of compounds that increase the absorption of polar molecules. Proceedings of the National Academy of Sciences of the United States of America. 94: 12218-23. PMID 9342389 DOI: 10.1073/pnas.94.22.12218  1
1996 Walker S, Sofia MJ, Kakarla R, Kogan NA, Wierichs L, Longley CB, Bruker K, Axelrod HR, Midha S, Babu S, Kahne D. Cationic facial amphiphiles: a promising class of transfection agents. Proceedings of the National Academy of Sciences of the United States of America. 93: 1585-90. PMID 8643675  0.96
1994 Walker SL, Andreotti AH, Kahne DE. NMR characterization of calicheamicin γ1 I bound to DNA Tetrahedron. 50: 1351-1360. DOI: 10.1016/S0040-4020(01)80623-2  1
1993 Silva DJ, Kahne DE. Studies of the 2:1 chromomycin A3-Mg2+ complex in methanol: Role of the carbohydrates in complex formation Journal of the American Chemical Society. 115: 7962-7970.  1
1992 Walker S, Landovitz R, Ding WD, Ellestad GA, Kahne D. Cleavage behavior of calicheamicin gamma 1 and calicheamicin T. Proceedings of the National Academy of Sciences of the United States of America. 89: 4608-12. PMID 1584797  0.96
1983 Stork G, Kahne DE. Stereocontrol in homogeneous catalytic hydrogenation via hydroxyl group coordination Journal of the American Chemical Society. 105: 1072-1073.  1
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