Michael H. Gelb - Publications

Affiliations: 
University of Washington, Seattle, Seattle, WA 
Area:
medicinal enzymology
Website:
http://depts.washington.edu/chem/people/faculty/gelb.html

305 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hong X, Daiker J, Sadilek M, Ruiz-Schultz N, Kumar AB, Norcross S, Dansithong W, Suhr T, Escolar ML, Ronald Scott C, Rohrwasser A, Gelb MH. Toward newborn screening of metachromatic leukodystrophy: results from analysis of over 27,000 newborn dried blood spots. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 33214709 DOI: 10.1038/s41436-020-01017-5  0.92
2020 Khaledi H, Gelb MH. Tandem Mass Spectrometry Enzyme Assays for Multiplex Detection of 10-Mucopolysaccharidoses in Dried Blood Spots and Fibroblasts. Analytical Chemistry. 92: 11721-11727. PMID 32786498 DOI: 10.1021/Acs.Analchem.0C01750  0.36
2020 Shen JJ, Davis JL, Hong X, Laningham FH, Gelb MH, Kim GE. A Case of Lysosomal Acid Lipase Deficiency Confirmed by Response to Sebelipase Alfa Therapy. Journal of Pediatric Gastroenterology and Nutrition. PMID 32740531 DOI: 10.1097/Mpg.0000000000002870  0.92
2020 Hong X, Daiker J, Sadilek M, DeBarber AE, Chiang J, Duan J, Bootsma AH, Huidekoper HH, Vaz FM, Gelb MH. Toward newborn screening of cerebrotendinous xanthomatosis: results of a biomarker research study using 32,000 newborn dried blood spots. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 32523054 DOI: 10.1038/S41436-020-0846-X  0.92
2020 Su P, Khaledi H, Waggoner C, Gelb MH. Detection of GM1-Gangliosidosis in Newborn Dried Blood Spots by Enzyme and Biomarker Assays Using Tandem Mass Spectrometry. Journal of Inherited Metabolic Disease. PMID 32506457 DOI: 10.1002/Jimd.12269  0.36
2020 Weinstock NI, Shin D, Dhimal N, Hong X, Irons EE, Silvestri NJ, Reed CB, Nguyen D, Sampson O, Cheng YC, Lau JTY, Bongarzone ER, Kofler J, Escolar ML, Gelb MH, et al. Macrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction. Neuron. PMID 32375064 DOI: 10.1016/J.Neuron.2020.03.031  0.92
2020 Herbst Z, Turgeon CT, Biski C, Khaledi H, Shoemaker NB, DeArmond PD, Smith S, Orsini J, Matern D, Gelb MH. Achieving Congruence among Reference Laboratories for Absolute Abundance Measurement of Analytes for Rare Diseases: Psychosine for Diagnosis and Prognosis of Krabbe Disease. International Journal of Neonatal Screening. 6. PMID 32373753 DOI: 10.3390/Ijns6020029  0.36
2020 Hong X, Sadilek M, Gelb MH. A highly multiplexed biochemical assay for analytes in dried blood spots: application to newborn screening and diagnosis of lysosomal storage disorders and other inborn errors of metabolism. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 32307446 DOI: 10.1038/S41436-020-0790-9  0.92
2020 Hong X, Kumar AB, Daiker J, Yi F, Sadilek M, De Mattia F, Fumagalli F, Calbi V, Damiano R, Bona MD, la Marca G, Vanderver AL, Waldman AT, Adang L, Sherbini O, ... ... Gelb MH, et al. Leukocyte and Dried Blood Spot Arylsulfatase A Assay by Tandem Mass Spectrometry. Analytical Chemistry. PMID 31922725 DOI: 10.1021/Acs.Analchem.9B05274  0.92
2019 Scott CR, Elliott S, Hong X, Huang JY, Kumar AB, Yi F, Pendem N, Chennamaneni NK, Gelb MH. Newborn Screening for Mucopolysaccharidoses: Results of a Pilot Study with 100 000 Dried Blood Spots. The Journal of Pediatrics. PMID 31732130 DOI: 10.1016/J.Jpeds.2019.09.036  0.92
2019 Kumar AB, Hong X, Yi F, Wood T, Gelb MH. Tandem mass spectrometry-based multiplex assays for α-mannosidosis and fucosidosis. Molecular Genetics and Metabolism. PMID 31235216 DOI: 10.1016/J.Ymgme.2019.05.016  0.92
2019 Sidhu R, Mondjinou Y, Qian M, Song H, Kumar AB, Hong X, Hsu FF, Dietzen DJ, Yanjanin NM, Porter FD, Berry-Kravis E, Vite CH, Gelb MH, Schaffer JE, Ory DS, et al. N-Acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease. Journal of Lipid Research. PMID 31201291 DOI: 10.1194/Jlr.Ra119000157  0.92
2019 Duchez AC, Boudreau LH, Naika GS, Rousseau M, Cloutier N, Levesque T, Gelb MH, Boilard E. Respective contribution of cytosolic phospholipase A2α and secreted phospholipase A IIA to inflammation and eicosanoid production in arthritis. Prostaglandins & Other Lipid Mediators. 143: 106340. PMID 31129176 DOI: 10.1016/J.Prostaglandins.2019.106340  0.36
2018 Nolin JD, Murphy RC, Gelb MH, Altemeier WA, Henderson WR, Hallstrand TS. Function of secreted phospholipase A group-X in asthma and allergic disease. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 30529275 DOI: 10.1016/J.Bbalip.2018.11.009  0.56
2018 Khaledi H, Liu Y, Masi S, Gelb MH. Detection of Infantile Batten Disease by Tandem Mass Spectrometry Assay of PPT1 Enzyme Activity in Dried Blood Spots. Analytical Chemistry. PMID 30204428 DOI: 10.1021/Acs.Analchem.8B03188  0.56
2018 Hong X, Gelb MH. One-step synthesis of carbon-13-labeled globotriaosylsphingosine (lyso-Gb3), an internal standard for biomarker analysis of Fabry disease. Molecular Genetics and Metabolism. PMID 30126819 DOI: 10.1016/J.Ymgme.2018.08.001  0.92
2018 Yi F, Hong X, Kumar AB, Zong C, Boons GJ, Scott CR, Turecek F, Robinson BH, Gelb MH. Detection of mucopolysaccharidosis III-A (Sanfilippo Syndrome-A) in dried blood spots (DBS) by tandem mass spectrometry. Molecular Genetics and Metabolism. PMID 30006231 DOI: 10.1016/J.Ymgme.2018.05.005  0.92
2018 Hong X, Kumar AB, Ronald Scott C, Gelb MH. Multiplex tandem mass spectrometry assay for newborn screening of X-linked adrenoleukodystrophy, biotinidase deficiency, and galactosemia with flexibility to assay other enzyme assays and biomarkers. Molecular Genetics and Metabolism. PMID 29680633 DOI: 10.1016/J.Ymgme.2018.03.012  0.92
2018 Masi S, Chennamaneni N, Turecek F, Scott CR, Gelb MH. Specific Substrate for the Assay of Lysosomal Acid Lipase. Clinical Chemistry. PMID 29339442 DOI: 10.1373/Clinchem.2017.282251  0.56
2017 Gelb MH, Ronald Scott C, Turecek F, Liao HC. Comparison of tandem mass spectrometry to fluorimetry for newborn screening of LSDs. Molecular Genetics and Metabolism Reports. 12: 80-81. PMID 28649517 DOI: 10.1016/J.Ymgmr.2017.05.004  0.56
2017 Liao HC, Spacil Z, Ghomashchi F, Escolar ML, Kurtzberg J, Orsini JJ, Turecek F, Ronald Scott C, Gelb MH. Lymphocyte Galactocerebrosidase Activity by LC-MS/MS for Post-Newborn Screening Evaluation of Krabbe Disease. Clinical Chemistry. PMID 28592445 DOI: 10.1373/Clinchem.2016.264952  0.56
2017 Escolar ML, Kiely BT, Shawgo E, Hong X, Gelb MH, Orsini JJ, Matern D, Poe MD. Psychosine, a marker of Krabbe phenotype and treatment effect. Molecular Genetics and Metabolism. PMID 28579020 DOI: 10.1016/J.Ymgme.2017.05.015  0.92
2017 Liu Y, Yi F, Kumar AB, Kumar Chennamaneni N, Hong X, Scott CR, Gelb MH, Turecek F. Multiplex Tandem Mass Spectrometry Enzymatic Activity Assay for Newborn Screening of the Mucopolysaccharidoses and Type 2 Neuronal Ceroid Lipofuscinosis. Clinical Chemistry. PMID 28428354 DOI: 10.1373/Clinchem.2016.269167  0.92
2017 Lin N, Huang J, Violante S, Orsini JJ, Caggana M, Hughes EE, Stevens C, DiAntonio L, Chieh Liao H, Hong X, Ghomashchi F, Babu Kumar A, Zhou H, Kornreich R, Wasserstein M, ... Gelb MH, et al. Liquid Chromatography-Tandem Mass Spectrometry Assay of Leukocyte Acid α-Glucosidase for Post-Newborn Screening Evaluation of Pompe Disease. Clinical Chemistry. PMID 28196920 DOI: 10.1373/Clinchem.2016.259036  0.92
2016 Orsini JJ, Saavedra-Matiz CA, Gelb MH, Caggana M. Newborn screening for Krabbe's disease. Journal of Neuroscience Research. 94: 1063-75. PMID 27638592 DOI: 10.1002/Jnr.23781  0.36
2016 Elliott S, Buroker N, Cournoyer JJ, Potier AM, Trometer JD, Elbin C, Schermer MJ, Kantola J, Boyce A, Turecek F, Gelb MH, Scott CR. Dataset and standard operating procedure for newborn screening of six lysosomal storage diseases: By tandem mass spectrometry. Data in Brief. 8: 915-24. PMID 27508243 DOI: 10.1016/J.Dib.2016.06.052  1
2016 Nolin JD, Ogden HL, Lai Y, Altemeier WA, Frevert CW, Bollinger JG, Naika GS, Kicic A, Stick SM, Lambeau G, Henderson WR, Gelb MH, Hallstrand TS. Identification of Epithelial Phospholipase A2 Receptor 1 (PLA2R1) as a Potential Target in Asthma. American Journal of Respiratory Cell and Molecular Biology. PMID 27448109 DOI: 10.1165/Rcmb.2015-0150Oc  0.6
2016 Schewe M, Franken PF, Sacchetti A, Schmitt M, Joosten R, Böttcher R, van Royen ME, Jeammet L, Payré C, Scott PM, Webb NR, Gelb M, Cormier RT, Lambeau G, Fodde R. Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer. Cell Stem Cell. PMID 27292189 DOI: 10.1016/J.Stem.2016.05.023  0.6
2016 Elliott S, Buroker N, Cournoyer JJ, Potier AM, Trometer JD, Elbin C, Schermer MJ, Kantola J, Boyce A, Turecek F, Gelb MH, Scott CR. Pilot study of newborn screening for six lysosomal storage diseases using Tandem Mass Spectrometry. Molecular Genetics and Metabolism. PMID 27238910 DOI: 10.1016/J.Ymgme.2016.05.015  1
2016 Yamamoto K, Miki Y, Sato H, Nishito Y, Gelb MH, Taketomi Y, Murakami M. Expression and function of group IIE phospholipase A2 in mouse skin. The Journal of Biological Chemistry. PMID 27226633 DOI: 10.1074/Jbc.M116.734657  1
2016 Miki Y, Kidoguchi Y, Sato M, Taketomi Y, Taya C, Muramatsu K, Gelb MH, Yamamoto K, Murakami M. Dual roles of group IID phospholipase A2 in inflammation and cancer. The Journal of Biological Chemistry. PMID 27226632 DOI: 10.1074/Jbc.M116.734624  1
2016 Ewing H, Fernández-Vega V, Spicer TP, Chase P, Brown S, Scampavia L, Roush WR, Riley S, Rosen H, Hodder P, Lambeau G, Gelb MH. Fluorometric High-Throughput Screening Assay for Secreted Phospholipases A2 Using Phospholipid Vesicles. Journal of Biomolecular Screening. PMID 27146384 DOI: 10.1177/1087057116646742  1
2015 Spacil Z, Babu Kumar A, Liao HC, Auray-Blais C, Stark S, Suhr TR, Scott CR, Turecek F, Gelb MH. Sulfatide Analysis by Mass Spectrometry for Screening of Metachromatic Leukodystrophy in Dried Blood and Urine Samples. Clinical Chemistry. PMID 26585924 DOI: 10.1373/Clinchem.2015.245159  1
2015 Yamamoto K, Miki Y, Sato M, Taketomi Y, Nishito Y, Taya C, Muramatsu K, Ikeda K, Nakanishi H, Taguchi R, Kambe N, Kabashima K, Lambeau G, Gelb MH, Murakami M. The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia. The Journal of Experimental Medicine. 212: 1901-19. PMID 26438362 DOI: 10.1084/Jem.20141904  1
2015 Kumar AB, Masi S, Ghomashchi F, Chennamaneni NK, Ito M, Scott CR, Turecek F, Gelb MH, Spacil Z. Tandem Mass Spectrometry Has a Larger Analytical Range than Fluorescence Assays of Lysosomal Enzymes: Application to Newborn Screening and Diagnosis of Mucopolysaccharidoses Types II, IVA, and VI. Clinical Chemistry. PMID 26369786 DOI: 10.1373/Clinchem.2015.242560  1
2015 Kumar AB, Spacil Z, Ghomashchi F, Masi S, Sumida T, Ito M, Turecek F, Scott CR, Gelb MH. Fluorimetric assays for N-acetylgalactosamine-6-sulfatase and arylsulfatase B based on the natural substrates for confirmation of mucopolysaccharidoses types IVA and VI. Clinica Chimica Acta; International Journal of Clinical Chemistry. PMID 26282597 DOI: 10.1016/J.Cca.2015.08.010  1
2015 Duchez AC, Boudreau LH, Bollinger J, Belleannée C, Cloutier N, Laffont B, Mendoza-Villarroel RE, Lévesque T, Rollet-Labelle E, Rousseau M, Allaeys I, Tremblay JJ, Poubelle PE, Lambeau G, Pouliot M, ... ... Gelb MH, et al. Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA. Proceedings of the National Academy of Sciences of the United States of America. PMID 26106157 DOI: 10.1073/Pnas.1507905112  1
2015 Rousseau M, Naika GS, Perron J, Jacques F, Gelb MH, Boilard E. Study of the role of cytosolic phospholipase A2 alpha in eicosanoid generation and thymocyte maturation in the thymus. Plos One. 10: e0126204. PMID 25969996 DOI: 10.1371/Journal.Pone.0126204  1
2015 Siegel JB, Smith AL, Poust S, Wargacki AJ, Bar-Even A, Louw C, Shen BW, Eiben CB, Tran HM, Noor E, Gallaher JL, Bale J, Yoshikuni Y, Gelb MH, Keasling JD, et al. Computational protein design enables a novel one-carbon assimilation pathway. Proceedings of the National Academy of Sciences of the United States of America. 112: 3704-9. PMID 25775555 DOI: 10.1073/Pnas.1500545112  1
2015 Ghomashchi F, Barcenas M, Turecek F, Scott CR, Gelb MH. Reliable Assay of Acid Sphingomyelinase Deficiency with the Mutation Q292K by Tandem Mass Spectrometry. Clinical Chemistry. 61: 771-2. PMID 25770139 DOI: 10.1373/Clinchem.2014.236448  1
2015 Rousseau M, Belleannee C, Duchez AC, Cloutier N, Levesque T, Jacques F, Perron J, Nigrovic PA, Dieude M, Hebert MJ, Gelb MH, Boilard E. Detection and quantification of microparticles from different cellular lineages using flow cytometry. Evaluation of the impact of secreted phospholipase A2 on microparticle assessment. Plos One. 10: e0116812. PMID 25587983 DOI: 10.1371/Journal.Pone.0116812  1
2015 Gelb MH, Scott CR, Turecek F. Newborn screening for lysosomal storage diseases. Clinical Chemistry. 61: 335-46. PMID 25477536 DOI: 10.1373/Clinchem.2014.225771  1
2014 Nagle AS, Khare S, Kumar AB, Supek F, Buchynskyy A, Mathison CJ, Chennamaneni NK, Pendem N, Buckner FS, Gelb MH, Molteni V. Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis. Chemical Reviews. PMID 25365529 DOI: 10.1021/Cr500365F  1
2014 Boudreau LH, Duchez AC, Cloutier N, Soulet D, Martin N, Bollinger J, Paré A, Rousseau M, Naika GS, Lévesque T, Laflamme C, Marcoux G, Lambeau G, Farndale RW, Pouliot M, ... ... Gelb MH, et al. Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. Blood. 124: 2173-83. PMID 25082876 DOI: 10.1182/Blood-2014-05-573543  1
2014 Barcenas M, Xue C, Marushchak-Vlaskin T, Scott CR, Gelb MH, Ture?ek F. Tandem mass spectrometry assays of palmitoyl protein thioesterase 1 and tripeptidyl peptidase activity in dried blood spots for the detection of neuronal ceroid lipofuscinoses in newborns. Analytical Chemistry. 86: 7962-8. PMID 25019629 DOI: 10.1021/Ac501994B  1
2014 Sato H, Taketomi Y, Ushida A, Isogai Y, Kojima T, Hirabayashi T, Miki Y, Yamamoto K, Nishito Y, Kobayashi T, Ikeda K, Taguchi R, Hara S, Ida S, Miyamoto Y, ... ... Gelb MH, et al. The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity. Cell Metabolism. 20: 119-32. PMID 24910243 DOI: 10.1016/J.Cmet.2014.05.002  1
2014 Kelvin AA, Degousee N, Banner D, Stefanski E, Le?n AJ, Angoulvant D, Paquette SG, Huang SS, Danesh A, Robbins CS, Noyan H, Husain M, Lambeau G, Gelb M, Kelvin DJ, et al. Lack of group X secreted phospholipase A₂ increases survival following pandemic H1N1 influenza infection. Virology. 454: 78-92. PMID 24725934 DOI: 10.1016/J.Virol.2014.01.030  1
2014 Chennamaneni NK, Kumar AB, Barcenas M, Spá?il Z, Scott CR, Ture?ek F, Gelb MH. Improved reagents for newborn screening of mucopolysaccharidosis types I, II, and VI by tandem mass spectrometry. Analytical Chemistry. 86: 4508-14. PMID 24694010 DOI: 10.1021/Ac5004135  1
2014 Fitterer B, Hall P, Antonishyn N, Desikan R, Gelb M, Lehotay D. Incidence and carrier frequency of Sandhoff disease in Saskatchewan determined using a novel substrate with detection by tandem mass spectrometry and molecular genetic analysis Molecular Genetics and Metabolism. 111: 382-389. PMID 24461908 DOI: 10.1016/J.Ymgme.2014.01.002  1
2014 Barcenas M, Suhr TR, Scott CR, Turecek F, Gelb MH. Quantification of sulfatides in dried blood and urine spots from metachromatic leukodystrophy patients by liquid chromatography/electrospray tandem mass spectrometry. Clinica Chimica Acta; International Journal of Clinical Chemistry. 433: 39-43. PMID 24370383 DOI: 10.1016/J.Cca.2013.12.016  1
2014 Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. The Journal of Biological Chemistry. 289: 1491-504. PMID 24297180 DOI: 10.1074/Jbc.M113.497651  1
2014 Ilic D, Bollinger JM, Gelb M, Mauro TM. sPLA2 and the epidermal barrier. Biochimica Et Biophysica Acta. 1841: 416-21. PMID 24269828 DOI: 10.1016/J.Bbalip.2013.11.002  1
2014 Lai Y, Altemeier WA, Vandree J, Piliponsky AM, Johnson B, Appel CL, Frevert CW, Hyde DM, Ziegler SF, Smith DE, Henderson WR, Gelb MH, Hallstrand TS. Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33. The Journal of Allergy and Clinical Immunology. 133: 1448-55. PMID 24220317 DOI: 10.1016/J.Jaci.2013.08.052  1
2014 Hallstrand TS, Lai Y, Hooper KA, Oslund RC, Altemeier WA, Matute-Bello G, Gelb MH. Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils Journal of Allergy and Clinical Immunology. DOI: 10.1016/j.jaci.2015.05.026  1
2013 Vindrieux D, Augert A, Girard CA, Gitenay D, Lallet-Daher H, Wiel C, Le Calve B, Gras B, Ferrand M, Verbeke S, De Launoit Y, Leroy X, Puisieux A, Aubert S, Perrais M, ... Gelb M, et al. PLA2R1 mediates tumor suppression by activating JAK2 Cancer Research. 73: 6334-6345. PMID 24008317 DOI: 10.1158/0008-5472.Can-13-0318  1
2013 Bollinger JG, Naika GS, Rohan G, Sadilek M, Gelb MH. LC/ESI-MS/MS detection of FAs by charge reversal derivatization with more than four orders of magnitude improvement in sensitivity. Journal of Lipid Research. 54: 3523-30. PMID 23945566 DOI: 10.1194/Jlr.D040782  1
2013 Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, ... ... Gelb MH, et al. Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators. The Journal of Experimental Medicine. 210: 1217-34. PMID 23690440 DOI: 10.1084/Jem.20121887  1
2013 Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, ... ... Gelb MH, et al. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nature Immunology. 14: 554-63. PMID 23624557 DOI: 10.1038/Ni.2586  1
2013 Hallstrand TS, Lai Y, Altemeier WA, Appel CL, Johnson B, Frevert CW, Hudkins KL, Bollinger JG, Woodruff PG, Hyde DM, Henderson WR, Gelb MH. Regulation and function of epithelial secreted phospholipase A2 group X in asthma. American Journal of Respiratory and Critical Care Medicine. 188: 42-50. PMID 23614662 DOI: 10.1164/Rccm.201301-0084Oc  1
2013 Lee LK, Bryant KJ, Bouveret R, Lei PW, Duff AP, Harrop SJ, Huang EP, Harvey RP, Gelb MH, Gray PP, Curmi PM, Cunningham AM, Church WB, Scott KF. Selective inhibition of human group IIA-secreted phospholipase A2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes. The Journal of Biological Chemistry. 288: 15269-79. PMID 23482564 DOI: 10.1074/Jbc.M112.397893  1
2013 Scott CR, Elliott S, Buroker N, Thomas LI, Keutzer J, Glass M, Gelb MH, Turecek F. Identification of infants at risk for developing Fabry, Pompe, or mucopolysaccharidosis-I from newborn blood spots by tandem mass spectrometry. The Journal of Pediatrics. 163: 498-503. PMID 23465405 DOI: 10.1016/J.Jpeds.2013.01.031  1
2013 Henderson WR, Ye X, Lai Y, Ni Z, Bollinger JG, Tien YT, Chi EY, Gelb MH. Key role of group v secreted phospholipase A2 in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling. Plos One. 8: e56172. PMID 23451035 DOI: 10.1371/Journal.Pone.0056172  1
2013 Spacil Z, Tatipaka H, Barcenas M, Scott CR, Turecek F, Gelb MH. High-throughput assay of 9 lysosomal enzymes for newborn screening. Clinical Chemistry. 59: 502-11. PMID 23315484 DOI: 10.1373/Clinchem.2012.189936  1
2012 Hallstrand TS, Lai Y, Henderson WR, Altemeier WA, Gelb MH. Epithelial regulation of eicosanoid production in asthma. Pulmonary Pharmacology & Therapeutics. 25: 432-7. PMID 23323271 DOI: 10.1016/J.Pupt.2012.02.004  1
2012 Oslund RC, Gelb MH. Biochemical characterization of selective inhibitors of human group IIA secreted phospholipase A(2) and hyaluronic acid-linked inhibitor conjugates. Biochemistry. 51: 8617-26. PMID 23020658 DOI: 10.1021/Bi301140B  1
2012 Pérez-Moreno G, Sealey-Cardona M, Rodrigues-Poveda C, Gelb MH, Ruiz-Pérez LM, Castillo-Acosta V, Urbina JA, González-Pacanowska D. Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei. International Journal For Parasitology. 42: 975-89. PMID 22964455 DOI: 10.1016/J.Ijpara.2012.07.012  1
2012 Orsini JJ, Martin MM, Showers AL, Bodamer OA, Zhang XK, Gelb MH, Caggana M. Lysosomal storage disorder 4+1 multiplex assay for newborn screening using tandem mass spectrometry: application to a small-scale population study for five lysosomal storage disorders. Clinica Chimica Acta; International Journal of Clinical Chemistry. 413: 1270-3. PMID 22548856 DOI: 10.1016/J.Cca.2012.04.012  1
2012 Thompson W, Oslund RC, Bollinger J, Ewing H, Gelb MH. High-throughput assay of secreted phospholipases Aâ‚‚ inhibitors. Methods in Molecular Biology (Clifton, N.J.). 861: 149-58. PMID 22426718 DOI: 10.1007/978-1-61779-600-5_10  1
2012 Aloulou A, Ali YB, Bezzine S, Gargouri Y, Gelb MH. Phospholipases: an overview. Methods in Molecular Biology (Clifton, N.J.). 861: 63-85. PMID 22426712 DOI: 10.1007/978-1-61779-600-5_4  1
2012 Wolfe BJ, Ghomashchi F, Kim T, Abam CA, Sadilek M, Jack R, Thompson JN, Scott CR, Gelb MH, Turecek F. New substrates and enzyme assays for the detection of mucopolysaccharidosis III (Sanfilippo Syndrome) types A, B, C, and D by tandem mass spectrometry. Bioconjugate Chemistry. 23: 557-64. PMID 22372747 DOI: 10.1021/Bc200609X  1
2011 Spá?il Z, Hui R, Gelb MH, Ture?ek F. Protonation sites and dissociation mechanisms of t-butylcarbamates in tandem mass spectrometric assays for newborn screening. Journal of Mass Spectrometry : Jms. 46: 1089-98. PMID 22012676 DOI: 10.1002/Jms.1993  1
2011 Jemel I, Ii H, Oslund RC, Payré C, Dabert-Gay AS, Douguet D, Chargui K, Scarzello S, Gelb MH, Lambeau G. Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells. The Journal of Biological Chemistry. 286: 36509-21. PMID 21878635 DOI: 10.1074/Jbc.M111.268540  1
2011 Degousee N, Kelvin DJ, Geisslinger G, Hwang DM, Stefanski E, Wang XH, Danesh A, Angioni C, Schmidt H, Lindsay TF, Gelb MH, Bollinger J, Payré C, Lambeau G, Arm JP, et al. Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia. The Journal of Biological Chemistry. 286: 35650-62. PMID 21849511 DOI: 10.1074/Jbc.M111.262733  1
2011 Yang JS, Valente C, Polishchuk RS, Turacchio G, Layre E, Moody DB, Leslie CC, Gelb MH, Brown WJ, Corda D, Luini A, Hsu VW. COPI acts in both vesicular and tubular transport. Nature Cell Biology. 13: 996-1003. PMID 21725317 DOI: 10.1038/Ncb2273  1
2011 Henderson WR, Oslund RC, Bollinger JG, Ye X, Tien YT, Xue J, Gelb MH. Blockade of human group X secreted phospholipase A2 (GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitor. The Journal of Biological Chemistry. 286: 28049-55. PMID 21652694 DOI: 10.1074/Jbc.M111.235812  1
2011 Shridas P, Bailey WM, Talbott KR, Oslund RC, Gelb MH, Webb NR. Group X secretory phospholipase A2 enhances TLR4 signaling in macrophages. Journal of Immunology (Baltimore, Md. : 1950). 187: 482-9. PMID 21622863 DOI: 10.4049/Jimmunol.1003552  1
2011 Spá?il Z, Elliott S, Reeber SL, Gelb MH, Scott CR, Ture?ek F. Comparative triplex tandem mass spectrometry assays of lysosomal enzyme activities in dried blood spots using fast liquid chromatography: application to newborn screening of Pompe, Fabry, and Hurler diseases. Analytical Chemistry. 83: 4822-8. PMID 21548611 DOI: 10.1021/Ac200417U  1
2011 Hallstrand TS, Lai Y, Ni Z, Oslund RC, Henderson WR, Gelb MH, Wenzel SE. Relationship between levels of secreted phospholipase A₂ groups IIA and X in the airways and asthma severity. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 41: 801-10. PMID 21255140 DOI: 10.1111/J.1365-2222.2010.03676.X  1
2011 Reed KA, Tucker DE, Aloulou A, Adler D, Ghomashchi F, Gelb MH, Leslie CC, Oates JA, Boutaud O. Functional characterization of mutations in inherited human cPLA₂ deficiency. Biochemistry. 50: 1731-8. PMID 21247147 DOI: 10.1021/Bi101877N  1
2011 Mouchlis VD, Magrioti V, Barbayianni E, Cermak N, Oslund RC, Mavromoustakos TM, Gelb MH, Kokotos G. Inhibition of secreted phospholipases A₂ by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations. Bioorganic & Medicinal Chemistry. 19: 735-43. PMID 21216150 DOI: 10.1016/J.Bmc.2010.12.030  1
2011 Wolfe BJ, Blanchard S, Sadilek M, Scott CR, Turecek F, Gelb MH. Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis II (Hunter Syndrome). Analytical Chemistry. 83: 1152-6. PMID 21192662 DOI: 10.1021/Ac102777S  1
2011 Bryant KJ, Bidgood MJ, Lei PW, Taberner M, Salom C, Kumar V, Lee L, Church WB, Courtenay B, Smart BP, Gelb MH, Cahill MA, Graham GG, McNeil HP, Scott KF. A bifunctional role for group IIA secreted phospholipase A2 in human rheumatoid fibroblast-like synoviocyte arachidonic acid metabolism. The Journal of Biological Chemistry. 286: 2492-503. PMID 21068383 DOI: 10.1074/Jbc.M110.123927  1
2011 Khaliq T, Sadilek M, Scott CR, Turecek F, Gelb MH. Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis IVA. Clinical Chemistry. 57: 128-31. PMID 21030685 DOI: 10.1373/Clinchem.2010.149880  1
2011 Zack M, Boyanovsky BB, Shridas P, Bailey W, Forrest K, Howatt DA, Gelb MH, de Beer FC, Daugherty A, Webb NR. Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice. Atherosclerosis. 214: 58-64. PMID 20833395 DOI: 10.1016/J.Atherosclerosis.2010.08.054  1
2010 Lai Y, Oslund RC, Bollinger JG, Henderson WR, Santana LF, Altemeier WA, Gelb MH, Hallstrand TS. Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X. The Journal of Biological Chemistry. 285: 41491-500. PMID 20974857 DOI: 10.1074/Jbc.M110.153338  1
2010 Duffey TA, Sadilek M, Scott CR, Turecek F, Gelb MH. Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). Analytical Chemistry. 82: 9587-91. PMID 20961069 DOI: 10.1021/Ac102090V  1
2010 Duffey TA, Bellamy G, Elliott S, Fox AC, Glass M, Turecek F, Gelb MH, Scott CR. A tandem mass spectrometry triplex assay for the detection of Fabry, Pompe, and mucopolysaccharidosis-I (Hurler). Clinical Chemistry. 56: 1854-61. PMID 20940330 DOI: 10.1373/Clinchem.2010.152009  1
2010 Shridas P, Bailey WM, Gizard F, Oslund RC, Gelb MH, Bruemmer D, Webb NR. Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2014-21. PMID 20844270 DOI: 10.1161/Atvbaha.110.210237  1
2010 Duffey TA, Khaliq T, Scott CR, Turecek F, Gelb MH. Design and synthesis of substrates for newborn screening of Maroteaux-Lamy and Morquio A syndromes. Bioorganic & Medicinal Chemistry Letters. 20: 5994-6. PMID 20833037 DOI: 10.1016/J.Bmcl.2010.08.080  1
2010 Fletcher S, Keaney EP, Cummings CG, Blaskovich MA, Hast MA, Glenn MP, Chang SY, Bucher CJ, Floyd RJ, Katt WP, Gelb MH, Van Voorhis WC, Beese LS, Sebti SM, Hamilton AD. Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. Journal of Medicinal Chemistry. 53: 6867-88. PMID 20822181 DOI: 10.1021/Jm1001748  1
2010 Ghomashchi F, Naika GS, Bollinger JG, Aloulou A, Lehr M, Leslie CC, Gelb MH. Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms. The Journal of Biological Chemistry. 285: 36100-11. PMID 20705608 DOI: 10.1074/Jbc.M110.165647  1
2010 Bollinger JG, Thompson W, Lai Y, Oslund RC, Hallstrand TS, Sadilek M, Turecek F, Gelb MH. Improved sensitivity mass spectrometric detection of eicosanoids by charge reversal derivatization. Analytical Chemistry. 82: 6790-6. PMID 20704368 DOI: 10.1021/Ac100720P  1
2010 Siegel JB, Zanghellini A, Lovick HM, Kiss G, Lambert AR, St Clair JL, Gallaher JL, Hilvert D, Gelb MH, Stoddard BL, Houk KN, Michael FE, Baker D. Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction. Science (New York, N.Y.). 329: 309-13. PMID 20647463 DOI: 10.1126/Science.1190239  1
2010 Whitty A, Gelb MH. Critical challenges and emerging paradigms in drug discovery. Current Opinion in Chemical Biology. 14: 437-9. PMID 20621548 DOI: 10.1016/J.Cbpa.2010.06.178  1
2010 Choiniere JR, Scott CR, Gelb MH, Turecek F. Direct assay of delta-aminolevulinic acid dehydratase in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Analytical Chemistry. 82: 6730-6. PMID 20583792 DOI: 10.1021/Ac101111M  1
2010 Boilard E, Lai Y, Larabee K, Balestrieri B, Ghomashchi F, Fujioka D, Gobezie R, Coblyn JS, Weinblatt ME, Massarotti EM, Thornhill TS, Divangahi M, Remold H, Lambeau G, Gelb MH, et al. A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis. Embo Molecular Medicine. 2: 172-87. PMID 20432503 DOI: 10.1002/Emmm.201000072  1
2010 Shridas P, Bailey WM, Boyanovsky BB, Oslund RC, Gelb MH, Webb NR. Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands. The Journal of Biological Chemistry. 285: 20031-9. PMID 20421306 DOI: 10.1074/Jbc.M109.090423  1
2010 Trinh K, Andrews L, Krause J, Hanak T, Lee D, Gelb M, Pallanck L. Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5525-32. PMID 20410106 DOI: 10.1523/Jneurosci.4777-09.2010  1
2010 Chipuk JE, Gelb MH, Brodbelt JS. Rapid and selective screening for sulfhydryl analytes in plasma and urine using surface-enhanced transmission mode desorption electrospray ionization mass spectrometry. Analytical Chemistry. 82: 4130-9. PMID 20402469 DOI: 10.1021/Ac100242B  1
2010 Granata F, Frattini A, Loffredo S, Staiano RI, Petraroli A, Ribatti D, Oslund R, Gelb MH, Lambeau G, Marone G, Triggiani M. Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2. Journal of Immunology (Baltimore, Md. : 1950). 184: 5232-41. PMID 20357262 DOI: 10.4049/Jimmunol.0902501  1
2010 Leslie CC, Gangelhoff TA, Gelb MH. Localization and function of cytosolic phospholipase A2alpha at the Golgi. Biochimie. 92: 620-6. PMID 20226226 DOI: 10.1016/J.Biochi.2010.03.001  1
2010 Olson ED, Nelson J, Griffith K, Nguyen T, Streeter M, Wilson-Ashworth HA, Gelb MH, Judd AM, Bell JD. Kinetic evaluation of cell membrane hydrolysis during apoptosis by human isoforms of secretory phospholipase A2. The Journal of Biological Chemistry. 285: 10993-1002. PMID 20139082 DOI: 10.1074/Jbc.M109.070797  1
2010 Zhang XK, Elbin CS, Turecek F, Scott R, Chuang WL, Keutzer JM, Gelb M. Multiplex lysosomal enzyme activity assay on dried blood spots using tandem mass spectrometry. Methods in Molecular Biology (Clifton, N.J.). 603: 339-50. PMID 20077085 DOI: 10.1007/978-1-60761-459-3_32  1
2010 Hallstrand TS, Wurfel MM, Lai Y, Ni Z, Gelb MH, Altemeier WA, Beyer RP, Aitken ML, Henderson WR. Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes. Plos One. 5: e8583. PMID 20052409 DOI: 10.1371/Journal.Pone.0008583  1
2010 Crowther GJ, He P, Rodenbough PP, Thomas AP, Kovzun KV, Leibly DJ, Bhandari J, Castaneda LJ, Hol WG, Gelb MH, Napuli AJ, Van Voorhis WC. Use of thermal melt curves to assess the quality of enzyme preparations. Analytical Biochemistry. 399: 268-75. PMID 20018159 DOI: 10.1016/J.Ab.2009.12.018  1
2010 Chipuk JE, Gelb MH, Brodbelt JS. Surface-enhanced transmission mode desorption electrospray ionization: increasing the specificity of ambient ionization mass spectrometric analyses. Analytical Chemistry. 82: 16-8. PMID 19902914 DOI: 10.1021/Ac902101E  1
2010 Bollinger JG, Ii H, Sadilek M, Gelb MH. Improved method for the quantification of lysophospholipids including enol ether species by liquid chromatography-tandem mass spectrometry. Journal of Lipid Research. 51: 440-7. PMID 19717841 DOI: 10.1194/Jlr.D000885  1
2010 Olson ED, Nelson J, Griffith K, Nguyen T, Streeter M, Wilson-Ashworth HA, Gelb MH, Judd AM, Bell JD. Kinetic evaluation of cell membrane hydrolysis during apoptosis by human isoforms of secretory phospholipase A2 (The Journal of Biological Chemistry (2010) 285, (10993-11002) DOI: 10.1074/jbc.A109.070797) Journal of Biological Chemistry. 285: 20421.  1
2009 Chennamaneni NK, Arif J, Buckner FS, Gelb MH. Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents. Bioorganic & Medicinal Chemistry Letters. 19: 6582-4. PMID 19875282 DOI: 10.1016/J.Bmcl.2009.10.029  1
2009 Rosenson RS, Gelb MH. Secretory phospholipase A2: a multifaceted family of proatherogenic enzymes. Current Cardiology Reports. 11: 445-51. PMID 19863869 DOI: 10.1007/s11886-009-0064-2  1
2009 Holt A, Koehorst RB, Rutters-Meijneke T, Gelb MH, Rijkers DT, Hemminga MA, Killian JA. Tilt and rotation angles of a transmembrane model peptide as studied by fluorescence spectroscopy. Biophysical Journal. 97: 2258-66. PMID 19843458 DOI: 10.1016/J.Bpj.2009.07.042  1
2009 Regan-Klapisz E, Krouwer V, Langelaar-Makkinje M, Nallan L, Gelb M, Gerritsen H, Verkleij AJ, Post JA. Golgi-associated cPLA2α regulates endothelial cell-cell junction integrity by controlling the trafficking of transmembrane junction proteins Molecular Biology of the Cell. 20: 4225-4234. PMID 19675210 DOI: 10.1091/Mbc.E08-02-0210  1
2009 Surrel F, Jemel I, Boilard E, Bollinger JG, Payré C, Mounier CM, Talvinen KA, Laine VJ, Nevalainen TJ, Gelb MH, Lambeau G. Group X phospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators. Molecular Pharmacology. 76: 778-90. PMID 19602573 DOI: 10.1124/Mol.108.053371  1
2009 Triggiani M, Giannattasio G, Calabrese C, Loffredo S, Granata F, Fiorello A, Santini M, Gelb MH, Marone G. Lung mast cells are a source of secreted phospholipases A2. The Journal of Allergy and Clinical Immunology. 124: 558-65, 565.e1-3. PMID 19541351 DOI: 10.1016/J.Jaci.2009.04.035  1
2009 Blanchard S, Turecek F, Gelb MH. Short synthetic sequence for 2-sulfation of alpha-L-iduronate glycosides. Carbohydrate Research. 344: 1032-3. PMID 19356745 DOI: 10.1016/J.Carres.2009.03.012  1
2009 Balestrieri B, Maekawa A, Xing W, Gelb MH, Katz HR, Arm JP. Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans. Journal of Immunology (Baltimore, Md. : 1950). 182: 4891-8. PMID 19342668 DOI: 10.4049/Jimmunol.0803776  1
2009 Hast MA, Fletcher S, Cummings CG, Pusateri EE, Blaskovich MA, Rivas K, Gelb MH, Van Voorhis WC, Sebti SM, Hamilton AD, Beese LS. Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chemistry & Biology. 16: 181-92. PMID 19246009 DOI: 10.1016/J.Chembiol.2009.01.014  1
2009 Torres-Santos EC, Sampaio-Santos MI, Buckner FS, Yokoyama K, Gelb M, Urbina JA, Rossi-Bergmann B. Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone. The Journal of Antimicrobial Chemotherapy. 63: 469-72. PMID 19176591 DOI: 10.1093/Jac/Dkn546  1
2009 Tucker DE, Ghosh M, Ghomashchi F, Loper R, Suram S, John BS, Girotti M, Bollinger JG, Gelb MH, Leslie CC. Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function. The Journal of Biological Chemistry. 284: 9596-611. PMID 19176526 DOI: 10.1074/Jbc.M807299200  1
2009 Giannattasio G, Lai Y, Granata F, Mounier CM, Nallan L, Oslund R, Leslie CC, Marone G, Lambeau G, Gelb MH, Triggiani M. Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis. Biochimica Et Biophysica Acta. 1791: 92-102. PMID 19130898 DOI: 10.1016/J.Bbalip.2008.12.002  1
2009 Su W, Yeku O, Olepu S, Genna A, Park JS, Ren H, Du G, Gelb MH, Morris AJ, Frohman MA. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Molecular Pharmacology. 75: 437-46. PMID 19064628 DOI: 10.1124/Mol.108.053298  1
2009 Kraus JM, Verlinde CLMJ, Karimi M, Lepesheva GI, Gelb MH, Buckner FS. Rational modification of a candidate cancer drug for use against Chagas disease (Journal of Medicinal Chemistry (2009) 52, (1639) DOI: 10.1021/jm801313t) Journal of Medicinal Chemistry. 52: 4979. DOI: 10.1021/Jm900929T  1
2009 Kraus JM, Verlinde CLMJ, Karimi M, Lepesheva GI, Gelb MH, Buckner FS. Corrections to Rational modification of a candidate cancer drug for use against Chagas disease (Journal of Medicinal Chemistry (2009) 52, (1639-1646) DOI: 10.1021/jm801313t) Journal of Medicinal Chemistry. 52: 4549. DOI: 10.1021/Jm900650S  1
2008 Patel MI, Singh J, Niknami M, Kurek C, Yao M, Lu S, Maclean F, King NJ, Gelb MH, Scott KF, Russell PJ, Boulas J, Dong Q. Cytosolic phospholipase A2-alpha: a potential therapeutic target for prostate cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 8070-9. PMID 19088022 DOI: 10.1158/1078-0432.Ccr-08-0566  1
2008 Blanchard S, Sadilek M, Scott CR, Turecek F, Gelb MH. Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis I. Clinical Chemistry. 54: 2067-70. PMID 19042989 DOI: 10.1373/Clinchem.2008.115410  1
2008 Wilensky RL, Shi Y, Mohler ER, Hamamdzic D, Burgert ME, Li J, Postle A, Fenning RS, Bollinger JG, Hoffman BE, Pelchovitz DJ, Yang J, Mirabile RC, Webb CL, Zhang L, ... ... Gelb MH, et al. Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development. Nature Medicine. 14: 1059-66. PMID 18806801 DOI: 10.1038/Nm.1870  1
2008 Fletcher S, Cummings CG, Rivas K, Katt WP, Hornéy C, Buckner FS, Chakrabarti D, Sebti SM, Gelb MH, Van Voorhis WC, Hamilton AD. Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation. Journal of Medicinal Chemistry. 51: 5176-97. PMID 18686940 DOI: 10.1021/Jm800113P  1
2008 Oslund RC, Cermak N, Gelb MH. Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. Journal of Medicinal Chemistry. 51: 4708-14. PMID 18605714 DOI: 10.1021/Jm800422V  1
2008 Tucker DE, Gijón MA, Spencer DM, Qiu ZH, Gelb MH, Leslie CC. Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages. Journal of Leukocyte Biology. 84: 798-806. PMID 18550790 DOI: 10.1189/Jlb.0308197  1
2008 Fan E, Baker D, Fields S, Gelb MH, Buckner FS, Van Voorhis WC, Phizicky E, Dumont M, Mehlin C, Grayhack E, Sullivan M, Verlinde C, Detitta G, Meldrum DR, Merritt EA, et al. Structural genomics of pathogenic protozoa: an overview. Methods in Molecular Biology (Clifton, N.J.). 426: 497-513. PMID 18542886 DOI: 10.1007/978-1-60327-058-8_33  1
2008 Lambeau G, Gelb MH. Biochemistry and physiology of mammalian secreted phospholipases A2. Annual Review of Biochemistry. 77: 495-520. PMID 18405237 DOI: 10.1146/Annurev.Biochem.76.062405.154007  1
2008 Wang Y, Scott CR, Gelb MH, Turecek F. Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Porphobilinogen deaminase. Analytical Chemistry. 80: 2606-11. PMID 18294005 DOI: 10.1021/Ac702244X  1
2008 Wang Y, Gatti P, Sadílek M, Scott CR, Turecek F, Gelb MH. Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Uroporphyrinogen decarboxylase and coproporphyrinogen III oxidase. Analytical Chemistry. 80: 2599-605. PMID 18294003 DOI: 10.1021/Ac702130N  1
2008 Yokoyama K, Gillespie JR, Van Voorhis WC, Buckner FS, Gelb MH. Protein geranylgeranyltransferase-I of Trypanosoma cruzi. Molecular and Biochemical Parasitology. 157: 32-43. PMID 17996962 DOI: 10.1016/J.Molbiopara.2007.09.006  1
2007 Ghomashchi F, Bollinger JG, Gelb MH. Facile preparation of leukotrienes C(4), D(4) and E(4) containing carbon-13 and nitrogen-15 for quantification of cysteinyl leukotrienes by mass spectrometry. Journal of Labelled Compounds & Radiopharmaceuticals. 50: 729-733. PMID 18516250 DOI: 10.1002/Jlcr.1414  1
2007 Tribler L, Jensen LT, Jørgensen K, Brünner N, Gelb MH, Nielsen HJ, Jensen SS. Increased expression and activity of group IIA and X secretory phospholipase A2 in peritumoral versus central colon carcinoma tissue. Anticancer Research. 27: 3179-85. PMID 17970059  1
2007 Hallstrand TS, Chi EY, Singer AG, Gelb MH, Henderson WR. Secreted phospholipase A2 group X overexpression in asthma and bronchial hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine. 176: 1072-8. PMID 17901411 DOI: 10.1164/Rccm.200707-1088Oc  1
2007 Gelb MH. Drug discovery for malaria: a very challenging and timely endeavor. Current Opinion in Chemical Biology. 11: 440-5. PMID 17761335 DOI: 10.1016/J.Cbpa.2007.05.038  1
2007 Wichmann O, Gelb MH, Schultz C. Probing phospholipase a(2) with fluorescent phospholipid substrates. Chembiochem : a European Journal of Chemical Biology. 8: 1555-69. PMID 17661302 DOI: 10.1002/Cbic.200600462  1
2007 Lu Y, Bottari P, Aebersold R, Turecek F, Gelb MH. Absolute quantification of specific proteins in complex mixtures using visible isotope-coded affinity tags. Methods in Molecular Biology (Clifton, N.J.). 359: 159-76. PMID 17484117 DOI: 10.1007/978-1-59745-255-7_11  1
2007 Turecek F, Scott CR, Gelb MH. Tandem mass spectrometry in the detection of inborn errors of metabolism for newborn screening. Methods in Molecular Biology (Clifton, N.J.). 359: 143-57. PMID 17484116 DOI: 10.1007/978-1-59745-255-7_10  1
2007 Henderson WR, Chi EY, Bollinger JG, Tien YT, Ye X, Castelli L, Rubtsov YP, Singer AG, Chiang GK, Nevalainen T, Rudensky AY, Gelb MH. Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. The Journal of Experimental Medicine. 204: 865-77. PMID 17403936 DOI: 10.1084/Jem.20070029  1
2007 Gillespie JR, Yokoyama K, Lu K, Eastman RT, Bollinger JG, Van Voorhis WC, Gelb MH, Buckner FS. C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins. Molecular and Biochemical Parasitology. 153: 115-24. PMID 17397944 DOI: 10.1016/J.Molbiopara.2007.02.009  1
2007 Ghosh M, Loper R, Ghomashchi F, Tucker DE, Bonventre JV, Gelb MH, Leslie CC. Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts. The Journal of Biological Chemistry. 282: 11676-86. PMID 17293613 DOI: 10.1074/Jbc.M608458200  1
2007 Rouault M, Le Calvez C, Boilard E, Surrel F, Singer A, Ghomashchi F, Bezzine S, Scarzello S, Bollinger J, Gelb MH, Lambeau G. Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor. Biochemistry. 46: 1647-62. PMID 17279628 DOI: 10.1021/Bi062119B  1
2007 Morgan D, Cherny VV, Finnegan A, Bollinger J, Gelb MH, DeCoursey TE. Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA2 alpha activity. The Journal of Physiology. 579: 327-44. PMID 17185330 DOI: 10.1113/Jphysiol.2006.124248  1
2007 Wang D, Wood T, Sadilek M, Scott CR, Turecek F, Gelb MH. Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: application to newborn screening for mucopolysaccharidosis II (Hunter disease). Clinical Chemistry. 53: 137-40. PMID 17082248 DOI: 10.1373/Clinchem.2006.077263  1
2007 Scott CR, Turecek F, Gelb MH. Newborn screening for lysosomal storage disorders Lysosomal Storage Disorders. 169-178. DOI: 10.1007/978-0-387-70909-3_12  1
2006 Boilard E, Rouault M, Surrel F, Le Calvez C, Bezzine S, Singer A, Gelb MH, Lambeau G. Secreted phospholipase A2 inhibitors are also potent blockers of binding to the M-type receptor. Biochemistry. 45: 13203-18. PMID 17073442 DOI: 10.1021/Bi061376D  1
2006 Gelb MH, Brunsveld L, Hrycyna CA, Michaelis S, Tamanoi F, Van Voorhis WC, Waldmann H. Therapeutic intervention based on protein prenylation and associated modifications. Nature Chemical Biology. 2: 518-28. PMID 16983387 DOI: 10.1038/Nchembio818  1
2006 Glenn MP, Chang SY, Hornéy C, Rivas K, Yokoyama K, Pusateri EE, Fletcher S, Cummings CG, Buckner FS, Pendyala PR, Chakrabarti D, Sebti SM, Gelb M, Van Voorhis WC, Hamilton AD. Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites. Journal of Medicinal Chemistry. 49: 5710-27. PMID 16970397 DOI: 10.1021/Jm060081V  1
2006 Seebacher J, Mallick P, Zhang N, Eddes JS, Aebersold R, Gelb MH. Protein cross-linking analysis using mass spectrometry, isotope-coded cross-linkers, and integrated computational data processing. Journal of Proteome Research. 5: 2270-82. PMID 16944939 DOI: 10.1021/Pr060154Z  1
2006 Blacken GR, Gelb MH, Turecek F. Metal affinity capture tandem mass spectrometry for the selective detection of phosphopeptides. Analytical Chemistry. 78: 6065-73. PMID 16944885 DOI: 10.1021/Ac060509Y  1
2006 Gelb MH, Turecek F, Scott CR, Chamoles NA. Direct multiplex assay of enzymes in dried blood spots by tandem mass spectrometry for the newborn screening of lysosomal storage disorders. Journal of Inherited Metabolic Disease. 29: 397-404. PMID 16763908 DOI: 10.1007/S10545-006-0265-4  1
2006 Eerola LI, Surrel F, Nevalainen TJ, Gelb MH, Lambeau G, Laine VJ. Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels. Biochimica Et Biophysica Acta. 1761: 745-56. PMID 16757211 DOI: 10.1016/J.Bbalip.2006.04.002  1
2006 Smart BP, Oslund RC, Walsh LA, Gelb MH. The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding. Journal of Medicinal Chemistry. 49: 2858-60. PMID 16686528 DOI: 10.1021/Jm060136T  1
2006 Rouault M, Rash LD, Escoubas P, Boilard E, Bollinger J, Lomonte B, Maurin T, Guillaume C, Canaan S, Deregnaucourt C, Schrével J, Doglio A, Gutiérrez JM, Lazdunski M, Gelb MH, et al. Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity. Biochemistry. 45: 5800-16. PMID 16669624 DOI: 10.1021/Bi060217R  1
2006 Mehlin C, Boni E, Buckner FS, Engel L, Feist T, Gelb MH, Haji L, Kim D, Liu C, Mueller N, Myler PJ, Reddy JT, Sampson JN, Subramanian E, Van Voorhis WC, et al. Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes. Molecular and Biochemical Parasitology. 148: 144-60. PMID 16644028 DOI: 10.1016/J.Molbiopara.2006.03.011  1
2006 Ghosh M, Loper R, Gelb MH, Leslie CC. Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. The Journal of Biological Chemistry. 281: 16615-24. PMID 16617059 DOI: 10.1074/Jbc.M601770200  1
2006 Ni Z, Okeley NM, Smart BP, Gelb MH. Intracellular actions of group IIA secreted phospholipase A2 and group IVA cytosolic phospholipase A2 contribute to arachidonic acid release and prostaglandin production in rat gastric mucosal cells and transfected human embryonic kidney cells. The Journal of Biological Chemistry. 281: 16245-55. PMID 16603549 DOI: 10.1074/Jbc.M513874200  1
2006 Huhtinen HT, Grönroos JO, Grönroos JM, Uksila J, Gelb MH, Nevalainen TJ, Laine VJO. Antibacterial effects of human group IIA and group XIIA phospholipase A2 against Helicobacter pylori in vitro Apmis. 114: 127-130. PMID 16519749 DOI: 10.1111/J.1600-0463.2006.Apm_330.X  1
2006 Vandal OH, Gelb MH, Ehrt S, Nathan CF. Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro. Infection and Immunity. 74: 1751-6. PMID 16495548 DOI: 10.1128/Iai.74.3.1751-1756.2006  1
2006 Gelb MH, Holm BP. A simple and inexpensive device for removal of solvent from a large collection of sample tubes Journal of Combinatorial Chemistry. 8: 15-17. PMID 16398548 DOI: 10.1021/Cc050104B  1
2006 Eastman RT, Buckner FS, Yokoyama K, Gelb MH, Van Voorhis WC. Fighting parasitic disease by blocking protein farnesylation Journal of Lipid Research. 47: 233-240. PMID 16339110 DOI: 10.1194/Jlr.R500016-Jlr200  1
2005 Forsell PK, Olsson AO, Andersson E, Nallan L, Gelb MH. Polychlorinated biphenyls induce arachidonic acid release in human platelets in a tamoxifen sensitive manner via activation of group IVA cytosolic phospholipase A2-alpha. Biochemical Pharmacology. 71: 144-55. PMID 16290172 DOI: 10.1016/J.Bcp.2005.10.014  1
2005 Mallampalli MP, Huyer G, Bendale P, Gelb MH, Michaelis S. Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome. Proceedings of the National Academy of Sciences of the United States of America. 102: 14416-21. PMID 16186497 DOI: 10.1073/Pnas.0503712102  1
2005 Petan T, Križaj I, Gelb MH, Pungerčar J. Ammodytoxins, potent presynaptic neurotoxins, are also highly efficient phospholipase A2 enzymes Biochemistry. 44: 12535-12545. PMID 16156665 DOI: 10.1021/Bi051024R  1
2005 Toth JI, Yang SH, Qiao X, Beigneux AP, Gelb MH, Moulson CL, Miner JH, Young SG, Fong LG. Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes Proceedings of the National Academy of Sciences of the United States of America. 102: 12873-12878. PMID 16129834 DOI: 10.1073/Pnas.0505767102  1
2005 Buckner FS, Eastman RT, Yokoyama K, Gelb MH, Van Voorhis WC. Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis Current Opinion in Investigational Drugs. 6: 791-797. PMID 16121685  1
2005 Tucker DE, Stewart A, Nallan L, Bendale P, Ghomashchi F, Gelb MH, Leslie CC. Group IVC cytosolic phospholipase A2γ is farnesylated and palmitoylated in mammalian cells Journal of Lipid Research. 46: 2122-2133. PMID 16061942 DOI: 10.1194/Jlr.M500230-Jlr200  1
2005 Yang SH, Bergo MO, Toth JI, Qiao X, Hu Y, Sandoval S, Meta M, Bendale P, Gelb MH, Young SG, Fong LG. Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Proceedings of the National Academy of Sciences of the United States of America. 102: 10291-6. PMID 16014412 DOI: 10.1073/Pnas.0504641102  1
2005 Nallan L, Bauer KD, Bendale P, Rivas K, Yokoyama K, Hornéy CP, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Hamilton A, Sebti S, Windsor WT, Weber PC, Buckner FS, ... ... Gelb MH, et al. Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. Journal of Medicinal Chemistry. 48: 3704-13. PMID 15916422 DOI: 10.1021/Jm0491039  1
2005 Nevalainen TJ, Eerola LI, Rintala E, Laine VJO, Lambeau G, Gelb MH. Time-resolved fluoroimmunoassays of the complete set of secreted phospholipases A2 in human serum Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1733: 210-223. PMID 15863368 DOI: 10.1016/J.Bbalip.2004.12.012  1
2005 Nielsen RD, Che K, Gelb MH, Robinson BH. A ruler for determining the position of proteins in membranes. Journal of the American Chemical Society. 127: 6430-42. PMID 15853351 DOI: 10.1021/Ja042782S  1
2005 Kita Y, Takahashi T, Uozumi N, Nallan L, Gelb MH, Shimizu T. Pathway-oriented profiling of lipid mediators in macrophages Biochemical and Biophysical Research Communications. 330: 898-906. PMID 15809081 DOI: 10.1016/J.Bbrc.2005.03.055  1
2005 Yuan C, Tu S, Gelb MH, Tsai MD. Unusual four-bond secondary H/D isotope effect supports a short-strong hydrogen bond between phospholipase A2 and a transition state analogue inhibitor. Biochemistry. 44: 4748-54. PMID 15779901 DOI: 10.1021/Bi047503S  1
2005 Babon A, Almunia C, Boccaccio C, Beaumelle B, Gelb MH, Ménez A, Maillère B, Abastado JP, Salcedo M, Gillet D. Cross-presentation of a CMV pp65 epitope by human dendritic cells using bee venom PLA2 as a membrane-binding vector Febs Letters. 579: 1658-1664. PMID 15757657 DOI: 10.1016/J.Febslet.2005.02.019  1
2005 Wang D, Eadala B, Sadilek M, Chamoles NA, Turecek F, Scott CR, Gelb MH. Tandem mass spectrometric analysis of dried blood spots for screening of mucopolysaccharidosis I in newborns. Clinical Chemistry. 51: 898-900. PMID 15695324 DOI: 10.1373/Clinchem.2004.047167  1
2005 Haas U, Podda M, Behne M, Gurrieri S, Alonso A, Fürstenberger G, Pfeilschifter J, Lambeau G, Gelb MH, Kaszkin M. Characterization and differentiation-dependent regulation of secreted phospholipases A in human keratinocytes and in healthy and psoriatic human skin. The Journal of Investigative Dermatology. 124: 204-11. PMID 15654975 DOI: 10.1111/J.0022-202X.2004.23513.X  1
2005 Granata F, Petraroli A, Boilard E, Bezzine S, Bollinger J, Del Vecchio L, Gelb MH, Lambeau G, Marone G, Triggiani M. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. Journal of Immunology (Baltimore, Md. : 1950). 174: 464-74. PMID 15611272 DOI: 10.4049/Jimmunol.174.1.464  1
2005 Rubin BB, Downey GP, Koh A, Degousee N, Ghomashchi F, Nallan L, Stefanski E, Harkin DW, Sun C, Smart BP, Lindsay TF, Cherepanov V, Vachon E, Kelvin D, Sadilek M, ... ... Gelb MH, et al. Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. The Journal of Biological Chemistry. 280: 7519-29. PMID 15475363 DOI: 10.1074/Jbc.M407438200  1
2004 Carrico D, Ohkanda J, Kendrick H, Yokoyama K, Blaskovich MA, Bucher CJ, Buckner FS, Van Voorhis WC, Chakrabarti D, Croft SL, Gelb MH, Sebti SM, Hamilton AD. In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability. Bioorganic & Medicinal Chemistry. 12: 6517-26. PMID 15556768 DOI: 10.1016/J.Bmc.2004.09.020  1
2004 Masuda S, Murakami M, Matsumoto S, Eguchi N, Urade Y, Lambeau G, Gelb MH, Ishikawa Y, Ishii T, Kudo I. Localization of various secretory phospholipase A 2 enzymes in male reproductive organs Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1686: 61-76. PMID 15522823 DOI: 10.1016/J.Bbalip.2004.08.017  1
2004 Landreville S, Coulombe S, Carrier P, Gelb MH, Guérin SL, Salesse C. Expression of phospholipases A2 and C in human corneal epithelial cells. Investigative Ophthalmology & Visual Science. 45: 3997-4003. PMID 15505048 DOI: 10.1167/Iovs.04-0084  1
2004 Bollinger JG, Diraviyam K, Ghomashchi F, Murray D, Gelb MH. Interfacial binding of bee venom secreted phospholipase A2 to membranes occurs predominantly by a nonelectrostatic mechanism. Biochemistry. 43: 13293-304. PMID 15491136 DOI: 10.1021/Bi049390I  1
2004 Ivanovski G, Petan T, Križaj I, Gelb MH, Gubenšek F, Pungerčar J. Basic amino acid residues in the β-structure region contribute, but not critically, to presynaptic neurotoxicity of ammodytoxin a Biochimica Et Biophysica Acta - Proteins and Proteomics. 1702: 217-225. PMID 15488774 DOI: 10.1016/J.Bbapap.2004.09.002  1
2004 Sved P, Scott KF, McLeod D, King NJC, Singh J, Tsatralis T, Nikolov B, Boulas J, Nallan L, Gelb MH, Sajinovic M, Graham GG, Russell PJ, Dong Q. Oncogenic action of secreted phospholipase A2 in prostate cancer Cancer Research. 64: 6934-6940. PMID 15466184 DOI: 10.1158/0008-5472.Can-03-3018  1
2004 Buhot C, Chenal A, Sanson A, Pouvelle-Moratille S, Gelb MH, Ménez A, Gillet D, Maillère B. Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity Protein Science. 13: 2970-2978. PMID 15459335 DOI: 10.1110/Ps.04885404  1
2004 Li Y, Scott CR, Chamoles NA, Ghavami A, Pinto BM, Turecek F, Gelb MH. Direct multiplex assay of lysosomal enzymes in dried blood spots for newborn screening. Clinical Chemistry. 50: 1785-96. PMID 15292070 DOI: 10.1373/Clinchem.2004.035907  0.56
2004 Lu Y, Bottari P, Turecek F, Aebersold R, Gelb MH. Absolute quantification of specific proteins in complex mixtures using visible isotope-coded affinity tags. Analytical Chemistry. 76: 4104-11. PMID 15253649 DOI: 10.1021/Ac049905B  1
2004 Nielsen RD, Canaan S, Gladden JA, Gelb MH, Mailer C, Robinson BH. Comparing continuous wave progressive saturation EPR and time domain saturation recovery EPR over the entire motional range of nitroxide spin labels. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 169: 129-63. PMID 15183364 DOI: 10.1016/J.Jmr.2004.04.010  1
2004 Leslie CC, Gelb MH. Assaying phospholipase A2 activity Methods in Molecular Biology (Clifton, N.J.). 284: 229-242. PMID 15173620 DOI: 10.1385/1-59259-816-1:229  1
2004 Smart BP, Pan YH, Weeks AK, Bollinger JG, Bahnson BJ, Gelb MH. Inhibition of the complete set of mammalian secreted phospholipases A(2) by indole analogues: a structure-guided study. Bioorganic & Medicinal Chemistry. 12: 1737-49. PMID 15028265 DOI: 10.1016/J.Bmc.2004.01.022  1
2004 Bottari P, Aebersold R, Turecek F, Gelb MH. Design and Synthesis of Visible Isotope-Coded Affinity Tags for the Absolute Quantification of Specific Proteins in Complex Mixtures Bioconjugate Chemistry. 15: 380-388. PMID 15025535 DOI: 10.1021/Bc034174S  1
2004 Okeley NM, Gelb MH. A designed probe for acidic phospholipids reveals the unique enriched anionic character of the cytosolic face of the mammalian plasma membrane. The Journal of Biological Chemistry. 279: 21833-40. PMID 15007075 DOI: 10.1074/Jbc.M313469200  1
2004 Mounier CM, Ghomashchi F, Lindsay MR, James S, Singer AG, Parton RG, Gelb MH. Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A2 occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A2-α Journal of Biological Chemistry. 279: 25024-25038. PMID 15007070 DOI: 10.1074/Jbc.M313019200  1
2004 Triggiani M, Giannattasio G, Balestrieri B, Granata F, Gelb MH, De Paulis A, Marone G. Differential modulation of mediator release from human basophils and mast cells by mizolastine Clinical and Experimental Allergy. 34: 241-249. PMID 14987304 DOI: 10.1111/J.1365-2222.2004.01851.X  1
2004 Li Y, Brockmann K, Turecek F, Scott CR, Gelb MH. Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: application to newborn screening for Krabbe disease. Clinical Chemistry. 50: 638-40. PMID 14981030 DOI: 10.1373/Clinchem.2003.028381  1
2004 Canaan S, Zádori Z, Ghomashchi F, Bollinger J, Sadilek M, Moreau ME, Tijssen P, Gelb MH. Interfacial enzymology of parvovirus phospholipases A2. The Journal of Biological Chemistry. 279: 14502-8. PMID 14726513 DOI: 10.1074/Jbc.M312630200  1
2004 Ohkanda J, Buckner FS, Lockman JW, Yokoyama K, Carrico D, Eastman R, de Luca-Fradley K, Davies W, Croft SL, Van Voorhis WC, Gelb MH, Sebti SM, Hamilton AD. Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. Journal of Medicinal Chemistry. 47: 432-45. PMID 14711313 DOI: 10.1021/Jm030236O  1
2003 Buckner F, Yokoyama K, Lockman J, Aikenhead K, Ohkanda J, Sadilek M, Sebti S, Van Voorhis W, Hamilton A, Gelb MH. A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents. Proceedings of the National Academy of Sciences of the United States of America. 100: 15149-53. PMID 14657358 DOI: 10.1073/Pnas.2535442100  1
2003 Rouault M, Bollinger JG, Lazdunski M, Gelb MH, Lambeau G. Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. Biochemistry. 42: 11494-503. PMID 14516201 DOI: 10.1021/Bi0349930  1
2003 Chabot S, Koumanov K, Lambeau G, Gelb MH, Balloy V, Chignard M, Whitsett JA, Touqui L. Inhibitory effects of surfactant protein A on surfactant phospholipid hydrolysis by secreted phospholipases A2 Journal of Immunology. 171: 995-1000. PMID 12847272 DOI: 10.4049/Jimmunol.171.2.995  1
2003 Gurrieri S, Fürstenberger G, Schadow A, Haas U, Singer AG, Ghomashchi F, Pfeilschifter J, Lambeau G, Gelb MH, Kaszkin M. Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis Journal of Investigative Dermatology. 121: 156-164. PMID 12839576 DOI: 10.1046/J.1523-1747.2003.12315.X  1
2003 Beers SA, Buckland AG, Giles N, Gelb MH, Wilton DC. Effect of tryptophan insertions on the properties of the human group IIA phospholipase A2: mutagenesis produces an enzyme with characteristics similar to those of the human group V phospholipase A2. Biochemistry. 42: 7326-38. PMID 12809488 DOI: 10.1021/Bi0343222  1
2003 Poi MJ, Tomaszewski JW, Yuan C, Dunlap CA, Andersen NH, Gelb MH, Tsai MD. A low-barrier hydrogen bond between histidine of secreted phospholipase A2 and a transition state analog inhibitor. Journal of Molecular Biology. 329: 997-1009. PMID 12798689 DOI: 10.1016/S0022-2836(03)00512-6  1
2003 Beck S, Lambeau G, Scholz-Pedretti K, Gelb MH, Janssen MJ, Edwards SH, Wilton DC, Pfeilschifter J, Kaszkin M. Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. The Journal of Biological Chemistry. 278: 29799-812. PMID 12782627 DOI: 10.1074/Jbc.M211763200  1
2003 Ferri N, Yokoyama K, Sadilek M, Paoletti R, Apitz-Castro R, Gelb MH, Corsini A. Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation British Journal of Pharmacology. 138: 811-818. PMID 12642382 DOI: 10.1038/Sj.Bjp.0705126  1
2003 Gelb MH, Van Voorhis WC, Buckner FS, Yokoyama K, Eastman R, Carpenter EP, Panethymitaki C, Brown KA, Smith DF. Protein farnesyl and N-myristoyl transferases: Piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics Molecular and Biochemical Parasitology. 126: 155-163. PMID 12615314 DOI: 10.1016/S0166-6851(02)00282-7  1
2003 Li Y, Ogata Y, Freeze HH, Scott CR, Turecek F, Gelb MH. Affinity capture and elution/electrospray ionization mass spectrometry assay of phosphomannomutase and phosphomannose isomerase for the multiplex analysis of congenital disorders of glycosylation types Ia and Ib. Analytical Chemistry. 75: 42-8. PMID 12530817 DOI: 10.1021/Ac0205053  1
2003 Murakami M, Masuda S, Shimbara S, Bezzine S, Lazdunski M, Lambeau G, Gelb MH, Matsukura S, Kokubu F, Adachi M, Kudo I. Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2S (groups III and XII) Journal of Biological Chemistry. 278: 10657-10667. PMID 12522102 DOI: 10.1074/Jbc.M211325200  1
2002 Choe J, Suresh S, Wisedchaisri G, Kennedy KJ, Gelb MH, Hol WG. Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase. Chemistry & Biology. 9: 1189-97. PMID 12445769 DOI: 10.1016/S1074-5521(02)00243-0  1
2002 Koprivnjak T, Peschel A, Gelb MH, Liang NS, Weiss JP. Role of charge properties of bacterial envelope in bactericidal action of human group IIA phospholipase A2 against Staphylococcus aureus. The Journal of Biological Chemistry. 277: 47636-44. PMID 12359734 DOI: 10.1074/Jbc.M205104200  1
2002 Singer AG, Ghomashchi F, Le Calvez C, Bollinger J, Bezzine S, Rouault M, Sadilek M, Nguyen E, Lazdunski M, Lambeau G, Gelb MH. Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2. The Journal of Biological Chemistry. 277: 48535-49. PMID 12359733 DOI: 10.1074/Jbc.M205855200  1
2002 Ogata Y, Scampavia L, R?zicka J, Scott CR, Gelb MH, Turecek F. Automated affinity capture-release of biotin-containing conjugates using a lab-on-valve apparatus coupled to UV/visible and electrospray ionization mass spectrometry. Analytical Chemistry. 74: 4702-8. PMID 12349973 DOI: 10.1021/Ac020039H  1
2002 Bezzine S, Bollinger JG, Singer AG, Veatch SL, Keller SL, Gelb MH. On the binding preference of human groups IIA and X phospholipases A2 for membranes with anionic phospholipids. The Journal of Biological Chemistry. 277: 48523-34. PMID 12244093 DOI: 10.1074/Jbc.M203137200  1
2002 Kuksa V, Bartl F, Maeda T, Jang GF, Ritter E, Heck M, Van Hooser JP, Liang Y, Filipek S, Gelb MH, Hofmann KP, Palczewski K. Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals. The Journal of Biological Chemistry. 277: 42315-24. PMID 12176994 DOI: 10.1074/Jbc.M206014200  1
2002 Pan YH, Yu BZ, Singer AG, Ghomashchi F, Lambeau G, Gelb MH, Jain MK, Bahnson BJ. Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes. The Journal of Biological Chemistry. 277: 29086-93. PMID 12161451 DOI: 10.1074/Jbc.M202531200  1
2002 Gelb MH, Hol WG. Parasitology. Drugs to combat tropical protozoan parasites. Science (New York, N.Y.). 297: 343-4. PMID 12130767 DOI: 10.1126/Science.1073126  1
2002 Clerici F, Gelmi ML, Yokoyama K, Pocar D, Van Voorhis WC, Buckner FS, Gelb MH. Isothiazole dioxides: Synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase Bioorganic and Medicinal Chemistry Letters. 12: 2217-2220. PMID 12127541 DOI: 10.1016/S0960-894X(02)00338-4  1
2002 Canaan S, Nielsen R, Ghomashchi F, Robinson BH, Gelb MH. Unusual mode of binding of human group IIA secreted phospholipase A2 to anionic interfaces as studied by continuous wave and time domain electron paramagnetic resonance spectroscopy. The Journal of Biological Chemistry. 277: 30984-90. PMID 12039961 DOI: 10.1074/Jbc.M203649200  1
2002 Murakami M, Yoshihara K, Shimbara S, Lambeau G, Singer A, Gelb MH, Sawada M, Inagaki N, Nagai H, Kudo I. Arachidonate release and eicosanoid generation by group IIE phospholipase A 2 Biochemical and Biophysical Research Communications. 292: 689-696. PMID 11922621 DOI: 10.1006/Bbrc.2002.6716  1
2002 Berg OG, Gelb MH, Tsai MD, Jain MK. Interfacial enzymology: the secreted phospholipase A(2)-paradigm. Chemical Reviews. 101: 2613-54. PMID 11749391 DOI: 10.1021/Cr990139W  0.32
2002 Degousee N, Ghomashchi F, Stefanski E, Singer A, Smart BP, Borregaard N, Reithmeier R, Lindsay TF, Lichtenberger C, Reinisch W, Lambeau G, Arm J, Tischfield J, Gelb MH, Rubin BB. Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. The Journal of Biological Chemistry. 277: 5061-73. PMID 11741884 DOI: 10.1074/Jbc.M109083200  1
2002 Verlinde CLMJ, Bressi JC, Choe J, Suresh S, Buckner FS, Van Voorhis WC, Michels PAM, Gelb MH, Hol WGJ. Protein structure-based design of anti-protozoal drugs Journal of the Brazilian Chemical Society. 13: 843-848.  1
2002 Ogata Y, Scampavia LD, Růžička J, Scott CR, Gelb MH, Tureček F. Automated affinity capture-release of biotin-containing conjugates using a lab-on-valve apparatus coupled to UV/VIS and electrospray ionization mass spectrometry Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 581-582.  1
2001 Ferri N, Arnaboldi L, Orlandi A, Yokoyama K, Gree R, Granata A, Hachem A, Paoletti R, Gelb MH, Corsini A. Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation Biochemical Pharmacology. 62: 1637-1645. PMID 11755117 DOI: 10.1016/S0006-2952(01)00808-5  1
2001 Gerber SA, Tureček F, Gelb MH. Design and synthesis of substrate and internal standard conjugates for profiling enzyme activity in the sanfilippo syndrome by affinity chromatography/electrospray ionization mass spectrometry Bioconjugate Chemistry. 12: 603-615. PMID 11459466 DOI: 10.1021/Bc010007L  1
2001 Bressi JC, Verlinde CL, Aronov AM, Shaw ML, Shin SS, Nguyen LN, Suresh S, Buckner FS, Van Voorhis WC, Kuntz ID, Hol WG, Gelb MH. Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. Journal of Medicinal Chemistry. 44: 2080-93. PMID 11405646 DOI: 10.1021/Jm000472O  1
2001 Nepomuceno-Silva JL, Yokoyama K, De Mello LDB, Mendonça SM, Paixaøo JC, Baron R, Faye JC, Buckner FS, Van Voorhis WC, Gelb MH, Lopes UG. TcRho1, a farnesylated Rho family homologue from Trypanosoma cruzi. Cloning, trans-splicing, and prenylation studies Journal of Biological Chemistry. 276: 29711-29718. PMID 11359782 DOI: 10.1074/jbc.M102920200  1
2001 Gerber SA, Scott CR, Turecek F, Gelb MH. Direct profiling of multiple enzyme activities in human cell lysates by affinity chromatography/electrospray ionization mass spectrometry: application to clinical enzymology. Analytical Chemistry. 73: 1651-7. PMID 11338575 DOI: 10.1021/ac0100650  1
2001 Ohkanda J, Lockman JW, Yokoyama K, Gelb MH, Croft SL, Kendrick H, Harrell MI, Feagin JE, Blaskovich MA, Sebti SM, Hamilton AD. Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity. Bioorganic & Medicinal Chemistry Letters. 11: 761-4. PMID 11277514 DOI: 10.1016/S0960-894X(01)00055-5  1
2001 Kennedy KJ, Bressi JC, Gelb MH. A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 11: 95-8. PMID 11206479 DOI: 10.1016/S0960-894X(00)00608-9  0.6
2001 Goldstein AS, Gelb MH, Yager P. Continuous and highly variable rate controlled release of model drugs from sphingolipid-based complex high axial ratio microstructures Journal of Controlled Release. 70: 125-138. PMID 11166413 DOI: 10.1016/S0168-3659(00)00335-7  1
2001 Goldstein AS, Gelb MH, Yager P. The relationship between the structure of the headgroup of sphingolipids and their ability to form complex high axial ratio microstructures Chemistry and Physics of Lipids. 109: 1-14. PMID 11163340 DOI: 10.1016/S0009-3084(00)00204-8  1
2001 Cook TA, Ghomashchi F, Gelb MH, Florio SK, Beavo JA. The delta subunit of type 6 phosphodiesterase reduces light-induced cGMP hydrolysis in rod outer segments. The Journal of Biological Chemistry. 276: 5248-55. PMID 11053432 DOI: 10.1074/Jbc.M004690200  1
2000 Bressi JC, Choe J, Hough MT, Buckner FS, Van Voorhis WC, Verlinde CL, Hol WG, Gelb MH. Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine. Journal of Medicinal Chemistry. 43: 4135-50. PMID 11063610 DOI: 10.1021/Jm000287A  1
2000 Cook TA, Ghomashchi F, Gelb MH, Florio SK, Beavo JA. Binding of the delta subunit to rod phosphodiesterase catalytic subunits requires methylated, prenylated C-termini of the catalytic subunits. Biochemistry. 39: 13516-23. PMID 11063588 DOI: 10.1021/Bi001070L  1
2000 Enomoto A, Murakami M, Valentin E, Lambeau G, Gelb MH, Kudo I. Redundant and segregated functions of granule-associated heparin-binding group II subfamily of secretory phospholipases A2 in the regulation of degranulation and prostaglandin D2 synthesis in mast cells Journal of Immunology. 165: 4007-4014. PMID 11034411 DOI: 10.4049/Jimmunol.165.7.4007  1
2000 Golisade A, Bressi JC, Van Calenbergh S, Gelb MH, Link A. Polymer-assisted solution-phase synthesis of 2'-amido-2'-deoxyadenosine derivatives targeted at the NAD(+)-binding sites of parasite enzymes. Journal of Combinatorial Chemistry. 2: 537-44. PMID 11029179 DOI: 10.1021/Cc0000343  0.36
2000 Buckner FS, Yokoyama K, Nguyen L, Grewal A, Erdjument-Bromage H, Tempst P, Strickland CL, Xiao L, Van Voorhis WC, Gelb MH. Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei. The Journal of Biological Chemistry. 275: 21870-6. PMID 10749864 DOI: 10.1074/Jbc.M000975200  1
2000 Jung LS, Shumaker-Parry JS, Campbell CT, Yee SS, Gelb MH. Quantification of tight binding to surface-immobilized phospholipid vesicles using surface plasmon resonance: Binding constant of phospholipase A2 Journal of the American Chemical Society. 122: 4177-4184. DOI: 10.1021/Ja993879V  1
2000 Goldstein AS, Gelb MH. An alternate preparation of thioester resin linkers for solid-phase synthesis of peptide C-terminal thioacids Tetrahedron Letters. 41: 2797-2800. DOI: 10.1016/S0040-4039(00)00266-5  1
1999 Buschbeck M, Ghomashchi F, Gelb MH, Watson SP, Börsch-Haubold AG. Stress stimuli increase calcium-induced arachidonic acid release through phosphorylation of cytosolic phospholipase A2 Biochemical Journal. 344: 359-366. PMID 10567216 DOI: 10.1042/0264-6021:3440359  1
1999 Börsch-Haubold AG, Ghomashchi F, Pasquet S, Goedert M, Cohen P, Gelb MH, Watson SP. Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways. European Journal of Biochemistry / Febs. 265: 195-203. PMID 10491174 DOI: 10.1046/J.1432-1327.1999.00722.X  1
1999 Ghomashchi F, Loo R, Balsinde J, Bartoli F, Apitz-Castro R, Clark JD, Dennis EA, Gelb MH. Trifluoromethyl ketones and methyl fluorophosphonates as inhibitors of group IV and VI phospholipases A2: Structure-function studies with vesicle, micelle, and membrane assays Biochimica Et Biophysica Acta - Biomembranes. 1420: 45-56. PMID 10446289 DOI: 10.1016/S0005-2736(99)00056-5  1
1999 Zhao X, Yokoyama K, Whitten ME, Huang J, Gelb MH, Palczewski K. A novel form of rhodopsin kinase from chicken retina and pineal gland. Febs Letters. 454: 115-21. PMID 10413107 DOI: 10.1016/S0014-5793(99)00764-4  0.4
1999 Corsini A, Farnsworth CC, McGeady P, Gelb MH, Glomset JA. Incorporation of radiolabeled prenyl alcohols and their analogs into mammalian cell proteins. A useful tool for studying protein prenylation Methods in Molecular Biology (Clifton, N.J.). 116: 125-144. PMID 10399150 DOI: 10.1385/1-59259-264-3:125  1
1999 Ball A, Nielsen R, Gelb MH, Robinson BH. Interfacial membrane docking of cytosolic phospholipase A2 C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance Proceedings of the National Academy of Sciences of the United States of America. 96: 6637-6642. PMID 10359764 DOI: 10.1073/Pnas.96.12.6637  1
1999 Bryant MD, Flick KE, Koduri RS, Wilton DC, Stoddard BL, Gelb MH. 1,3-Dioxane-4,6-dione-5-carboxamide-based inhibitors of human group IIA phospholipase A: X-ray structure of the complex and interfacial selection of inhibitors from a structural library. Bioorganic & Medicinal Chemistry Letters. 9: 1097-102. PMID 10328292 DOI: 10.1016/S0960-894X(99)00147-X  1
1999 Han SK, Kim KP, Koduri R, Bittova L, Munoz NM, Leff AR, Wilton DC, Gelb MH, Cho W. Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2. The Journal of Biological Chemistry. 274: 11881-8. PMID 10207008 DOI: 10.1074/Jbc.274.17.11881  1
1999 Aronov AM, Suresh S, Buckner FS, Van Voorhis WC, Verlinde CL, Opperdoes FR, Hol WG, Gelb MH. Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 96: 4273-8. PMID 10200252 DOI: 10.1073/Pnas.96.8.4273  1
1999 Stecher H, Gelb MH, Saari JC, Palczewski K. Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein. The Journal of Biological Chemistry. 274: 8577-85. PMID 10085092 DOI: 10.1074/Jbc.274.13.8577  1
1999 Lee KC, Carlson PA, Goldstein AS, Yager P, Gelb MH. Protection of a decapeptide from proteolytic cleavage by lipidation and self-assembly into high-axial-ratio microstructures: a kinetic and structural study Langmuir. 15: 5500-5508. DOI: 10.1021/La9900775  1
1999 Gerber SA, Scott CR, Turecek F, Gelb MH. Analysis of rates of multiple enzymes in cell lysates by electrospray ionization mass spectrometry [8] Journal of the American Chemical Society. 121: 1102-1103. DOI: 10.1021/Ja982878K  1
1998 Lin Y, Ghomashchi F, Nielsen R, Snitko Y, Yu BZ, Han SK, Cho W, Wilton DC, Jain MK, Robinson BH, Gelb MH. Binding of bee venom and human group IIa phospholipases A2 to membranes: a minor role for electrostatics. Biochemical Society Transactions. 26: 341-5. PMID 9765875 DOI: 10.1042/Bst0260341  1
1998 Yokoyama K, Trobridge P, Buckner FS, Van Voorhis WC, Stuart KD, Gelb MH. Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kDa subunits as a new target for antiparasite therapeutics Journal of Biological Chemistry. 273: 26497-26505. PMID 9756885 DOI: 10.1074/Jbc.273.41.26497  1
1998 Yokoyama K, Trobridge P, Buckner FS, Scholten J, Stuart KD, Van Voorhis WC, Gelb MH. The effects of protein farnesyltransferase inhibitors on trypanosomatids: Inhibition of protein farnesylation and cell growth Molecular and Biochemical Parasitology. 94: 87-97. PMID 9719512 DOI: 10.1016/S0166-6851(98)00053-X  1
1998 Bernstein BE, Williams DM, Bressi JC, Kuhn P, Gelb MH, Blackburn GM, Hol WG. A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from Trypanosoma brucei. Journal of Molecular Biology. 279: 1137-48. PMID 9642090 DOI: 10.1006/Jmbi.1998.1835  0.6
1998 Lee KC, Lukyanov AN, Gelb MH, Yager P. Formation of high axial ratio microstructures from peptides modified with glutamic acid dialkyl amides Biochimica Et Biophysica Acta - Biomembranes. 1371: 168-184. PMID 9630609 DOI: 10.1016/S0005-2736(97)00267-8  1
1998 Hixon MS, Ball A, Gelb MH. Calcium-dependent and -independent interfacial binding and catalysis of cytosolic group IV phospholipase A2. Biochemistry. 37: 8516-26. PMID 9622504 DOI: 10.1021/Bi980416D  1
1998 Ghomashchi F, Lin Y, Hixon MS, Yu BZ, Annand R, Jain MK, Gelb MH. Interfacial recognition by bee venom phospholipase A2: insights into nonelectrostatic molecular determinants by charge reversal mutagenesis. Biochemistry. 37: 6697-710. PMID 9578553 DOI: 10.1021/Bi972525I  1
1998 Lin Y, Nielsen R, Murray D, Hubbell WL, Mailer C, Robinson BH, Gelb MH. Docking phospholipase A2 on membranes using electrostatic potential-modulated spin relaxation magnetic resonance. Science (New York, N.Y.). 279: 1925-9. PMID 9506941 DOI: 10.1126/Science.279.5358.1925  1
1998 Börsch-Haubold AG, Bartoli F, Asselin J, Dudler T, Kramer RM, Apitz-Castro R, Watson SP, Gelb MH. Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells Journal of Biological Chemistry. 273: 4449-4458. PMID 9468497 DOI: 10.1074/Jbc.273.8.4449  1
1997 Goldstein AS, Lukyanov AN, Carlson PA, Paul Yager, Gelb MH. Formation of high-axial-ratio-microstructures from natural and synthetic sphingolipids Chemistry and Physics of Lipids. 88: 21-36. PMID 9297852 DOI: 10.1016/S0009-3084(97)00042-X  1
1997 Yokoyama K, Lin Y, Stuart KD, Gelb MH. Prenylation of proteins in Trypanosoma brucei Molecular and Biochemical Parasitology. 87: 61-69. PMID 9233673 DOI: 10.1016/S0166-6851(97)00043-1  1
1997 Carlson PA, Gelb MH, Yager P. Zero-order interfacial enzymatic degradation of phospholipid tubules Biophysical Journal. 73: 230-238. PMID 9199787 DOI: 10.1016/S0006-3495(97)78063-9  1
1997 Yokoyama K, Zimmerman K, Scholten J, Gelb MH. Differential prenyl pyrophosphate binding to mammalian protein geranylgeranyltransferase-I and protein farnesyltransferase and its consequence on the specificity of protein prenylation. The Journal of Biological Chemistry. 272: 3944-52. PMID 9020098 DOI: 10.1074/Jbc.272.7.3944  0.4
1996 Annand RR, Kontoyianni M, Penzotti JE, Dudler T, Lybrand TP, Gelb MH. Active site of bee venom phospholipase A2: the role of histidine-34, aspartate-64 and tyrosine-87. Biochemistry. 35: 4591-601. PMID 8605210 DOI: 10.1021/Bi9528412  1
1995 Bayburt T, Yu BZ, Street I, Ghomashchi F, Laliberté F, Perrier H, Wang Z, Homan R, Jain MK, Gelb MH. Continuous, vesicle-based fluorimetric assays of 14- and 85-kDa phospholipases A2. Analytical Biochemistry. 232: 7-23. PMID 8600835 DOI: 10.1006/Abio.1995.9967  1
1995 McIntosh JM, Ghomashchi F, Gelb MH, Dooley DJ, Stoehr SJ, Giordani AB, Naisbitt SR, Olivera BM. Conodipine-M, a novel phospholipase A2 isolated from the venom of the marine snail Conus magus. The Journal of Biological Chemistry. 270: 3518-26. PMID 7876086 DOI: 10.1074/Jbc.270.8.3518  1
1995 Glover S, de Carvalho MS, Bayburt T, Jonas M, Chi E, Leslie CC, Gelb MH. Translocation of the 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen. The Journal of Biological Chemistry. 270: 15359-67. PMID 7797525 DOI: 10.1074/Jbc.270.25.15359  0.36
1995 Liu L, Jang GF, Farnsworth CC, Yokoyama K, Glomset JA, Gelb MH. Synthetic prenylated peptides: Studying prenyl protein-specific endoprotease and other aspects of protein prenylation Methods in Enzymology. 250: 189-206. PMID 7651150 DOI: 10.1016/0076-6879(95)50072-3  1
1995 Gelb MH, Reiss Y, Ghomashchi F, Farnsworth CC. Exploring the specificity of prenyl protein-specific methyltransferase with synthetic prenylated rab peptides Bioorganic and Medicinal Chemistry Letters. 5: 881-886. DOI: 10.1016/0960-894X(95)00134-F  1
1994 Gronich J, Konieczkowski M, Gelb MH, Nemenoff RA, Sedor JR. Interleukin 1α causes rapid activation of cytosolic phospholipase A2 by phosphorylation in rat mesangial cells Journal of Clinical Investigation. 93: 1224-1233. PMID 8132762 DOI: 10.1172/Jci117076  1
1994 Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA. Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A Proceedings of the National Academy of Sciences of the United States of America. 91: 11963-11967. PMID 7991565 DOI: 10.1073/Pnas.91.25.11963  1
1993 Dudler T, Chen WQ, Wang S, Schneider T, Annand RR, Dempcy RO, Crameri R, Gmachl M, Suter M, Gelb MH. High-level expression in Escherichia coli and rapid purification of enzymatically active honey bee venom phospholipase A2. Biochimica Et Biophysica Acta. 1165: 201-10. PMID 1450215 DOI: 10.1016/0005-2760(92)90188-2  0.4
1992 Glomset JA, Gelb MH, Farnsworth CC. Geranylgeranylated proteins Biochemical Society Transactions. 20: 479-484. PMID 1397644 DOI: 10.1042/bst0200479  1
1991 Finegold AA, Johnson DI, Farnsworth CC, Gelb MH, Judd SR, Glomset JA, Tamanoi F. Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product Proceedings of the National Academy of Sciences of the United States of America. 88: 4448-4452. PMID 2034682 DOI: 10.1073/Pnas.88.10.4448  1
1991 Scott DL, Otwinowski Z, Gelb MH, Sigler PB. Crystal structure of bee-venom phospholipase A2: correction. Science (New York, N.Y.). 252: 764. PMID 2028251 DOI: 10.1126/Science.2028251  1
1991 Scott DL, White SP, Browning JL, Rosa JJ, Gelb MH, Sigler PB. Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate. Science (New York, N.Y.). 254: 1007-10. PMID 1948070 DOI: 10.1126/Science.1948070  1
1991 Farnsworth CC, Kawata M, Yoshida Y, Takai Y, Gelb MH, Glomset JA. C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester Proceedings of the National Academy of Sciences of the United States of America. 88: 6196-6200. PMID 1906176 DOI: 10.1073/Pnas.88.14.6196  1
1991 Yamane HK, Farnsworth CC, Xie HY, Evans T, Howald WN, Gelb MH, Glomset JA, Clarke S, Fung BK. Membrane-binding domain of the small G protein G25K contains an S-(all-trans-geranylgeranyl)cysteine methyl ester at its carboxyl terminus. Proceedings of the National Academy of Sciences of the United States of America. 88: 286-90. PMID 1898776 DOI: 10.1073/Pnas.88.1.286  1
1990 Yuan W, Quinn DM, Sigler PB, Gelb MH. Kinetic and inhibition studies of phospholipase A2 with short-chain substrates and inhibitors. Biochemistry. 29: 6082-94. PMID 2383571 DOI: 10.1021/Bi00477A028  1
1990 Farnsworth CC, Gelb MH, Glomset JA. Identification of geranylgeranyl-modified proteins in HeLa cells Science. 247: 320-322. PMID 2296721 DOI: 10.1126/Science.2296721  1
1990 Scott DL, Otwinowski Z, Gelb MH, Sigler PB. Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue. Science (New York, N.Y.). 250: 1563-6. PMID 2274788 DOI: 10.1126/Science.2274788  1
1990 Scott DL, White SP, Otwinowski Z, Yuan W, Gelb MH, Sigler PB. Interfacial catalysis: the mechanism of phospholipase A2. Science (New York, N.Y.). 250: 1541-6. PMID 2274785 DOI: 10.1126/Science.2274785  1
1990 Glomset JA, Gelb MH, Farnsworth CC. Prenyl proteins in eukaryotic cells: a new type of membrane anchor Trends in Biochemical Sciences. 15: 139-142. PMID 2187294 DOI: 10.1016/0968-0004(90)90213-U  1
1990 Goodman LE, Judd SR, Farnsworth CC, Powers S, Gelb MH, Glomset JA, Tamanoi F. Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins. Proceedings of the National Academy of Sciences of the United States of America. 87: 9665-9. PMID 2124698 DOI: 10.1073/Pnas.87.24.9665  1
1990 Kawata M, Farnsworth CC, Yoshida Y, Gelb MH, Glomset JA, Takai Y. Posttranslationally processed structure of the human platelet protein smg p21B: Evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine Proceedings of the National Academy of Sciences of the United States of America. 87: 8960-8964. PMID 2123345 DOI: 10.1073/Pnas.87.22.8960  1
1990 Yamane HK, Farnsworth CC, Xie HY, Howald W, Fung BK, Clarke S, Gelb MH, Glomset JA. Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini. Proceedings of the National Academy of Sciences of the United States of America. 87: 5868-72. PMID 2116010 DOI: 10.1073/PNAS.87.15.5868  1
1990 Farnsworth CC, Casey PJ, Howald WN, Glomset JA, Gelb MH. Structural characterization of prenyl groups attached to proteins Methods. 1: 231-240. DOI: 10.1016/S1046-2023(05)80322-6  1
1987 Fearon K, Spaltenstein A, Hopkins PB, Gelb MH. Fluoro ketone containing peptides as inhibitors of human renin. Journal of Medicinal Chemistry. 30: 1617-22. PMID 3305947 DOI: 10.1021/Jm00392A016  1
1986 Gelb MH, Abeles RH. Substituted isatoic anhydrides: selective inactivators of trypsin-like serine proteases. Journal of Medicinal Chemistry. 29: 585-9. PMID 3514913 DOI: 10.1002/Chin.198649216  1
1986 Ringe D, Mottonen JM, Gelb MH, Abeles RH. X-ray diffraction analysis of the inactivation of chymotrypsin by 3-benzyl-6-chloro-2-pyrone. Biochemistry. 25: 5633-8. PMID 3096374 DOI: 10.1021/Bi00367A043  1
1985 Ringe D, Seaton BA, Gelb MH, Abeles RH. Inactivation of chymotrypsin by 5-benzyl-6-chloro-2-pyrone: 13C NMR and X-ray diffraction analyses of the inactivator-enzyme complex. Biochemistry. 24: 64-8. PMID 3994973 DOI: 10.1021/Bi00322A011  1
1985 Gelb MH, Svaren JP, Abeles RH. Fluoro ketone inhibitors of hydrolytic enzymes. Biochemistry. 24: 1813-7. PMID 2990541 DOI: 10.1021/Bi00329A001  1
1984 Gelb MH, Abeles RH. Mechanism of inactivation of chymotrypsin by 3-benzyl-6-chloro-2-pyrone. Biochemistry. 23: 6596-604. PMID 6529572 DOI: 10.1021/Bi00321A049  1
1984 Sligar SG, Gelb MH, Heimbrook DC. Bio-organic chemistry and cytochrome P-450-dependent catalysis. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 14: 63-86. PMID 6372267 DOI: 10.3109/00498258409151399  0.4
1982 Gelb MH, Heimbrook DC, Mälkönen P, Sligar SG. Stereochemistry and deuterium isotope effects in camphor hydroxylation by the cytochrome P450cam monoxygenase system. Biochemistry. 21: 370-7. PMID 7074020 DOI: 10.1021/Bi00531A026  0.4
1982 Gelb MH, Malkonen P, Sligar SG. Cytochrome P450cam catalyzed epoxidation of dehydrocamphor. Biochemical and Biophysical Research Communications. 104: 853-8. PMID 7073732 DOI: 10.1016/0006-291X(82)91327-4  0.4
1982 Gelb MH, Toscano WA, Sligar SG. Chemical mechanisms for cytochrome P-450 oxidation: spectral and catalytic properties of a manganese-substituted protein. Proceedings of the National Academy of Sciences of the United States of America. 79: 5758-62. PMID 6964386 DOI: 10.1073/Pnas.79.19.5758  0.4
1981 Gould PV, Gelb MH, Sligar SG. Interaction of 5-bromocamphor with cytochrome P-450 cam. Production of 5-ketocamphor from a mixed spin state hemoprotein. The Journal of Biological Chemistry. 256: 6686-91. PMID 7240237  0.4
1980 Harris DC, Gelb MH. Binding of xylenol orange to transferrin. Demonstration of metal-anion linkage Bba - Protein Structure. 623: 1-9. PMID 7378464 DOI: 10.1016/0005-2795(80)90002-1  1
1980 Gelb MH, Harris DC. Correlation of proton release and ultraviolet difference spectra associated with metal binding by transferrin Archives of Biochemistry and Biophysics. 200: 93-98. PMID 7362264 DOI: 10.1016/0003-9861(80)90335-5  1
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