cached image

Andrew D. Hamilton, Ph.D. - Publications

Affiliations: 
1977-1980 Chemistry University of Cambridge, Cambridge, England, United Kingdom 
 1981-1986 Chemistry Princeton University, Princeton, NJ 
 1986-1997 Chemistry and Biochemistry University of Pittsburgh, Pittsburgh, PA, United States 
 1997-2008 Biochemistry and Administration (Provost) Yale University, New Haven, CT 
 2009-2016 Administration (Vice Chancellor) University of Oxford, Oxford, United Kingdom 
 2016- Administration (President) New York University, New York, NY, United States 
Area:
chemical biology
Website:
https://www.nyu.edu/about/leadership-university-administration/office-of-the-president.html

287 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Maity D, Howarth M, Vogel MC, Magzoub M, Hamilton AD. Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity. Journal of the American Chemical Society. PMID 33600171 DOI: 10.1021/jacs.0c09967  0.64
2020 Peacock H, Henriques ST, Benfield AH, Elliott AG, Luo J, Luccarelli J, Nagano M, Craik DJ, Hamilton AD. Antimicrobial peptide mimetics based on a diphenylacetylene scaffold: synthesis, conformational analysis and activity. Chemmedchem. PMID 32754982 DOI: 10.1002/cmdc.202000474  0.8
2019 Meisel JW, Hu CT, Hamilton AD. Heterofunctionalized Cavitands by Macrocyclization of Sequence-Defined Foldamers. Organic Letters. PMID 31535554 DOI: 10.1021/acs.orglett.9b02708  0.68
2019 Sebti SM, Kazi A, Xiang S, Yang H, Chen L, Kennedy P, Ayaz M, Fletcher S, Cummings C, Lawrence HR, Beato F, Kang Y, Kim MP, Delitto A, Underwood PW, ... ... Hamilton AD, et al. Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31227505 DOI: 10.1158/1078-0432.CCR-18-3399  0.72
2019 Maity D, Kumar S, Curreli F, Debnath A, Hamilton A. α-Helix-Mimetic Foldamers for Targeting HIV-1 TAR RNA. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30825250 DOI: 10.1002/chem.201900139  1
2018 Meisel JW, Hu CT, Hamilton AD. Mimicry of a β-Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer. Organic Letters. PMID 29897248 DOI: 10.1021/acs.orglett.8b01463  0.68
2018 Lee CH, Yu JR, Kumar S, Jin Y, LeRoy G, Bhanu N, Kaneko S, Garcia BA, Hamilton AD, Reinberg D. Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin. Molecular Cell. PMID 29681499 DOI: 10.1016/j.molcel.2018.03.020  1
2018 Kumar S, Henning A, Magzoub M, Hamilton AD. Peptidomimetic-based Multi-Domain Targeting Offers Critical Evaluation of Aβ Structure and Toxic Function. Journal of the American Chemical Society. PMID 29648815 DOI: 10.1021/jacs.7b13401  1
2018 Kumar S, Vogel MC, Hamilton AD. Teaching an old scaffold new recognition tricks: oligopyrrolamide antagonists of IAPP aggregation. Organic & Biomolecular Chemistry. PMID 29303519 DOI: 10.1039/c7ob02910a  1
2017 Luccarelli J, Jones IM, Thompson S, Hamilton AD. Unpicking the determinants of amide NHO[double bond, length as m-dash]C hydrogen bond strength with diphenylacetylene molecular balances. Organic & Biomolecular Chemistry. PMID 29058730 DOI: 10.1039/c7ob02026k  1
2017 Kumar S, Henning-Knechtel A, Chehade I, Magzoub M, Hamilton AD. Foldamer-mediated Structural Rearrangement Attenuates Aβ Oligomerization and Cytotoxicity. Journal of the American Chemical Society. PMID 29058422 DOI: 10.1021/jacs.7b08259  1
2017 Kumar S, Hamilton AD. α-Helix Mimetics as Modulators of Aβ Self-Assembly. Journal of the American Chemical Society. PMID 28273416 DOI: 10.1021/jacs.6b09734  1
2016 Peacock H, Luo J, Yamashita T, Luccarelli J, Thompson S, Hamilton AD. Non-covalent S···O interactions control conformation in a scaffold that disrupts islet amyloid polypeptide fibrillation. Chemical Science. 7: 6435-6439. PMID 28451100 DOI: 10.1039/c6sc00756b  1
2016 Busschaert N, Thompson S, Hamilton AD. An α-helical peptidomimetic scaffold for dynamic combinatorial library formation. Chemical Communications (Cambridge, England). PMID 27892554 DOI: 10.1039/c6cc07787k  1
2016 O'Brien MJ, Lee JY, Carnethon MR, Ackermann RT, Vargas MC, Hamilton A, Mohanty N, Rittner SS, Park JN, Hassan A, Buchanan DR, Liu L, Feinglass J. Detecting Dysglycemia Using the 2015 United States Preventive Services Task Force Screening Criteria: A Cohort Analysis of Community Health Center Patients. Plos Medicine. 13: e1002074. PMID 27403739 DOI: 10.1371/journal.pmed.1002074  0.32
2016 Knipe PC, Thompson S, Hamilton AD. Acid-mediated topological control in a functionalized foldamer. Chemical Communications (Cambridge, England). PMID 27045691 DOI: 10.1039/c6cc01496h  1
2016 Peacock H, Thinnes CC, Kawamura A, Hamilton AD. Tetracyanoresorcin[4]arene selectively recognises trimethyllysine and inhibits its enzyme-catalysed demethylation Supramolecular Chemistry. 1-7. DOI: 10.1080/10610278.2016.1140898  1
2015 Knipe PC, Thompson S, Hamilton AD. Ion-mediated conformational switches. Chemical Science. 6: 1630-1639. PMID 28694943 DOI: 10.1039/c4sc03525a  1
2015 Yamashita T, Knipe PC, Busschaert N, Thompson S, Hamilton AD. A Modular Synthesis of Conformationally Preorganised Extended β-Strand Peptidomimetics. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26384862 DOI: 10.1002/chem.201501366  1
2015 Yamashita T, Knipe PC, Busschaert N, Thompson S, Hamilton AD. A Modular Synthesis of Conformationally Preorganised Extended β-Strand Peptidomimetics. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26333029 DOI: 10.1002/chem.201503218  1
2015 Ross JE, Knipe PC, Thompson S, Hamilton AD. Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26264561 DOI: 10.1002/chem.201502690  1
2015 Kumar S, Schlamadinger DE, Brown MA, Dunn JM, Mercado B, Hebda JA, Saraogi I, Rhoades E, Hamilton AD, Miranker AD. Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics. Chemistry & Biology. 22: 369-78. PMID 25754474 DOI: 10.1016/j.chembiol.2015.01.006  1
2015 German EA, Ross JE, Knipe PC, Don MF, Thompson S, Hamilton AD. β-Strand mimetic foldamers rigidified through Dipolar repulsion. Angewandte Chemie (International Ed. in English). 54: 2649-52. PMID 25599889 DOI: 10.1002/anie.201410290  1
2015 Jayatunga MK, Thompson S, McKee TC, Chan MC, Reece KM, Hardy AP, Sekirnik R, Seden PT, Cook KM, McMahon JB, Figg WD, Schofield CJ, Hamilton AD. Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). European Journal of Medicinal Chemistry. 94: 509-16. PMID 25023609 DOI: 10.1016/j.ejmech.2014.06.006  1
2015 Knipe PC, Thompson S, Hamilton AD. Ion-mediated conformational switches Chemical Science. 6: 1630-1639. DOI: 10.1039/c4sc03525a  1
2015 Kulikov OV, Kumar S, Magzoub M, Knipe PC, Saraogi I, Thompson S, Miranker AD, Hamilton AD. Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation Tetrahedron Letters. DOI: 10.1016/j.tetlet.2015.02.132  1
2014 Wang X, Pan M, Wen J, Tang Y, Hamilton AD, Li Y, Qian C, Liu Z, Wu W, Guo J. A novel artificial nerve graft for repairing long-distance sciatic nerve defects: a self-assembling peptide nanofiber scaffold-containing poly(lactic-co-glycolic acid) conduit. Neural Regeneration Research. 9: 2132-41. PMID 25657734 DOI: 10.4103/1673-5374.147944  0.88
2014 Knipe PC, Jones IM, Thompson S, Hamilton AD. Remote conformational control of a molecular switch via methylation and deprotonation. Organic & Biomolecular Chemistry. 12: 9384-8. PMID 25317972 DOI: 10.1039/c4ob01991a  1
2014 Knipe PC, Lingard H, Jones IM, Thompson S, Hamilton AD. A Lewis acid-mediated conformational switch. Organic & Biomolecular Chemistry. 12: 7937-41. PMID 25184700 DOI: 10.1039/c4ob01556h  1
2014 Jones IM, Knipe PC, Michaelos T, Thompson S, Hamilton AD. Redox-dependent conformational switching of diphenylacetylenes. Molecules (Basel, Switzerland). 19: 11316-32. PMID 25090120 DOI: 10.3390/molecules190811316  1
2014 Lingard H, Han JT, Thompson AL, Leung IK, Scott RT, Thompson S, Hamilton AD. Diphenylacetylene-linked peptide strands induce bidirectional β-sheet formation. Angewandte Chemie (International Ed. in English). 53: 3650-3. PMID 24554626 DOI: 10.1002/anie.201309353  1
2014 Jayatunga MK, Thompson S, Hamilton AD. α-Helix mimetics: outwards and upwards. Bioorganic & Medicinal Chemistry Letters. 24: 717-24. PMID 24433858 DOI: 10.1016/j.bmcl.2013.12.003  1
2013 Nevola L, Rodriguez JM, Thompson S, Hamilton AD. Super-secondary structure peptidomimetics: design and synthesis of an α-α hairpin analogue. Supramolecular Chemistry. 25: 586-590. PMID 26052191 DOI: 10.1080/10610278.2013.817581  1
2013 Martucci WE, Rodriguez JM, Vargo MA, Marr M, Hamilton AD, Anderson KS. Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein-protein interaction in C. hominis TS-DHFR. Medchemcomm. 4. PMID 24324854 DOI: 10.1039/C3MD00141E  1
2013 Peltier AC, Myers MI, Artibee KJ, Hamilton AD, Yan Q, Guo J, Shi Y, Wang L, Li J. Evaluation of dermal myelinated nerve fibers in diabetes mellitus. Journal of the Peripheral Nervous System : Jpns. 18: 162-7. PMID 23781963 DOI: 10.1111/jns5.12027  0.88
2013 Wolk AB, Garand E, Jones IM, Hamilton AD, Johnson MA. Quantifying intrinsic ion-driven conformational changes in diphenylacetylene supramolecular switches with cryogenic ion vibrational spectroscopy. The Journal of Physical Chemistry. A. 117: 5962-9. PMID 23305426 DOI: 10.1021/jp3111925  1
2013 Simister PC, Luccarelli J, Thompson S, Appella DH, Feller SM, Hamilton AD. Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen. Bioorganic & Medicinal Chemistry. 21: 4027-33. PMID 23182216 DOI: 10.1016/j.bmc.2012.10.023  1
2013 Cummings CG, Hamilton AD. Expedient route to functionalized and water soluble 5-6-5 imidazole-phenyl-thiazole based α-helix mimetics Tetrahedron. 69: 1663-1668. DOI: 10.1016/j.tet.2012.11.070  1
2013 Kulikov OV, Thompson S, Xu H, Incarvito CD, Scott RTW, Saraogi I, Nevola L, Hamilton AD. Design and synthesis of oligoamide-based double α-helix mimetics European Journal of Organic Chemistry. 3433-3445. DOI: 10.1002/ejoc.201300363  1
2012 Adler MJ, Scott RT, Hamilton AD. Enaminone-based mimics of extended and hydrophilic α-helices. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 12974-7. PMID 22936425 DOI: 10.1002/chem.201202120  1
2012 Sutherell CL, Thompson S, Scott RT, Hamilton AD. Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics. Chemical Communications (Cambridge, England). 48: 9834-6. PMID 22936296 DOI: 10.1039/c2cc34791a  1
2012 Ghosh PS, Hamilton AD. Noncovalent template-assisted mimicry of multiloop protein surfaces: assembling discontinuous and functional domains. Journal of the American Chemical Society. 134: 13208-11. PMID 22839643 DOI: 10.1021/ja305360q  1
2012 Thompson S, Hamilton AD. Amphiphilic α-helix mimetics based on a benzoylurea scaffold. Organic & Biomolecular Chemistry. 10: 5780-2. PMID 22532001 DOI: 10.1039/c2ob25273b  1
2012 Tsou LK, Chen CH, Dutschman GE, Cheng YC, Hamilton AD. Blocking HIV-1 entry by a gp120 surface binding inhibitor. Bioorganic & Medicinal Chemistry Letters. 22: 3358-61. PMID 22487177 DOI: 10.1016/j.bmcl.2012.02.079  1
2012 Jamieson AG, Russell D, Hamilton AD. A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic. Chemical Communications (Cambridge, England). 48: 3709-11. PMID 22399148 DOI: 10.1039/c2cc30295k  1
2012 Ghosh PS, Hamilton AD. Supramolecular dendrimers: convenient synthesis by programmed self-assembly and tunable thermoresponsivity. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 2361-5. PMID 22267264 DOI: 10.1002/chem.201103051  1
2012 Zhang W, Zhan X, Gao M, Hamilton AD, Liu Z, Jiang Y, Su H, Dai X, He B, Kang X, Zeng Y, Wu W, Guo J. Self-assembling peptide nanofiber scaffold enhanced with RhoA inhibitor CT04 improves axonal regrowth in the transected spinal cord Journal of Nanomaterials. 2012. DOI: 10.1155/2012/724857  0.88
2012 Kulikov OV, Hamilton AD. Synthesis of the novel trimeric benzamides - Potential inhibitors of protein-protein interactions Rsc Advances. 2: 2454-2461. DOI: 10.1039/c2ra01153k  1
2012 Thompson S, Vallinayagam R, Adler MJ, Scott RTW, Hamilton AD. Double-sided α-helix mimetics Tetrahedron. 68: 4501-4505. DOI: 10.1016/j.tet.2011.11.010  1
2011 Jones IM, Lingard H, Hamilton AD. pH-dependent conformational switching in 2,6-benzamidodiphenylacetylenes. Angewandte Chemie (International Ed. in English). 50: 12569-71. PMID 22173825 DOI: 10.1002/anie.201106241  1
2011 Berndt N, Hamilton AD, Sebti SM. Targeting protein prenylation for cancer therapy. Nature Reviews. Cancer. 11: 775-91. PMID 22020205 DOI: 10.1038/nrc3151  1
2011 Rehman A, Hamilton A, Chung A, Baker GA, Wang Z, Zeng X. Differential solute gas response in ionic-liquid-based QCM arrays: elucidating design factors responsible for discriminative explosive gas sensing. Analytical Chemistry. 83: 7823-33. PMID 21863884 DOI: 10.1021/ac201583c  1
2011 Adler MJ, Hamilton AD. Oligophenylenaminones as scaffolds for α-helix mimicry. The Journal of Organic Chemistry. 76: 7040-7. PMID 21739975 DOI: 10.1021/jo200917d  1
2011 Tavassoli A, Hamilton AD, Spring DR. Small molecules in biology. Chemical Society Reviews. 40: 4269-70. PMID 21720613 DOI: 10.1039/c1cs90028e  1
2011 Balasis ME, Forinash KD, Chen YA, Fulp WJ, Coppola D, Hamilton AD, Cheng JQ, Sebti SM. Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2852-62. PMID 21536547 DOI: 10.1158/1078-0432.CCR-10-2544  1
2011 Jones IM, Hamilton AD. Anion-dependent switching: dynamically controlling the conformation of hydrogen-bonded diphenylacetylenes. Angewandte Chemie (International Ed. in English). 50: 4597-600. PMID 21495140 DOI: 10.1002/anie.201100144  1
2011 Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. The Journal of Biological Chemistry. 286: 9382-92. PMID 21148306 DOI: 10.1074/jbc.M110.203638  1
2011 Adler MJ, Jamieson AG, Hamilton AD. Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions. Current Topics in Microbiology and Immunology. 348: 1-23. PMID 20827522 DOI: 10.1007/82_2010_91  1
2011 Kulikov OV, Incarvito C, Hamilton AD. Hydrophobic side-chain interactions in a family of dimeric amide foldamers-potential alpha-helix mimetics Tetrahedron Letters. 52: 3705-3709. DOI: 10.1016/j.tetlet.2011.05.004  1
2011 Berndt N, Hamilton AD, Sebti SM. Geranylgeranyltransferase-1 Inhibitors Enzymes. 30: 129-163. DOI: 10.1016/B978-0-12-415922-8.00006-9  1
2010 Margulies D, Hamilton AD. Combinatorial protein recognition as an alternative approach to antibody-mimetics. Current Opinion in Chemical Biology. 14: 705-12. PMID 20829097 DOI: 10.1016/j.cbpa.2010.07.017  1
2010 Fletcher S, Keaney EP, Cummings CG, Blaskovich MA, Hast MA, Glenn MP, Chang SY, Bucher CJ, Floyd RJ, Katt WP, Gelb MH, Van Voorhis WC, Beese LS, Sebti SM, Hamilton AD. Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. Journal of Medicinal Chemistry. 53: 6867-88. PMID 20822181 DOI: 10.1021/jm1001748  1
2010 Jones IM, Hamilton AD. Designed molecular switches: controlling the conformation of benzamido-diphenylacetylenes. Organic Letters. 12: 3651-3. PMID 20669923 DOI: 10.1021/ol101397y  1
2010 Cummings CG, Hamilton AD. Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics. Current Opinion in Chemical Biology. 14: 341-6. PMID 20430687 DOI: 10.1016/j.cbpa.2010.04.001  1
2010 Rosenzweig BA, Ross NT, Adler MJ, Hamilton AD. Altered binding of a multimeric protein by changing the self-assembling properties of its substrate. Journal of the American Chemical Society. 132: 6749-54. PMID 20415446 DOI: 10.1021/ja100485n  1
2010 Tsou LK, Dutschman GE, Gullen EA, Telpoukhovskaia M, Cheng YC, Hamilton AD. Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold. Bioorganic & Medicinal Chemistry Letters. 20: 2137-9. PMID 20202840 DOI: 10.1016/j.bmcl.2010.02.043  1
2010 Saha S, Cai J, Eiler D, Hamilton AD. Programing the formation of DNA and PNA quadruplexes by pi-pi-stacking interactions. Chemical Communications (Cambridge, England). 46: 1685-7. PMID 20177616 DOI: 10.1039/b915955j  1
2010 Ross NT, Katt WP, Hamilton AD. Synthetic mimetics of protein secondary structure domains. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 368: 989-1008. PMID 20123744 DOI: 10.1098/rsta.2009.0210  1
2010 Cai J, Niedzwiedzki DM, Frank HA, Hamilton AD. Ultrafast energy transfer within pyropheophorbide-a tethered to self-assembling DNA quadruplex. Chemical Communications (Cambridge, England). 46: 544-6. PMID 20062856 DOI: 10.1039/b908435e  1
2010 Saraogi I, Hebda JA, Becerril J, Estroff LA, Miranker AD, Hamilton AD. Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation. Angewandte Chemie (International Ed. in English). 49: 736-9. PMID 20029853 DOI: 10.1002/anie.200901694  1
2010 Cheng Y, Tsou LK, Cai J, Aya T, Dutschman GE, Gullen EA, Grill SP, Chen AP, Lindenbach BD, Hamilton AD, Cheng YC. A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro. Antimicrobial Agents and Chemotherapy. 54: 197-206. PMID 19901090 DOI: 10.1128/AAC.01206-09  1
2010 Becerril J, Rodriguez JM, Wyrembak PN, Hamilton AD. Inhibition of Protein-Protein Interactions by Peptide Mimics Protein Surface Recognition: Approaches For Drug Discovery. 105-131. DOI: 10.1002/9780470972137.ch5  1
2009 Jain RK, Tsou LK, Hamilton AD. Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates. Tetrahedron Letters. 50: 2787-2789. PMID 20352130 DOI: 10.1016/j.tetlet.2009.03.153  1
2009 Wang Y, Hong L, Tapriyal D, Kim IC, Paik IH, Crosthwaite JM, Hamilton AD, Thies MC, Beckman EJ, Enick RM, Johnson JK. Design and evaluation of nonfluorous CO2-soluble oligomers and polymers. The Journal of Physical Chemistry. B. 113: 14971-80. PMID 19845375 DOI: 10.1021/jp9073812  1
2009 Park KK, Park JW, Hamilton AD. Novel 7-(dimethylamino)fluorene-based fluorescent probes and their binding to human serum albumin. Organic & Biomolecular Chemistry. 7: 4225-32. PMID 19795061 DOI: 10.1039/b911605b  1
2009 Hebda JA, Saraogi I, Magzoub M, Hamilton AD, Miranker AD. A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes. Chemistry & Biology. 16: 943-50. PMID 19778722 DOI: 10.1016/j.chembiol.2009.08.013  1
2009 Pierce SE, Wang J, Jayawickramarajah J, Hamilton AD, Brodbelt JS. Examination of the effect of the annealing cation on higher order structures containing guanine or isoguanine repeats. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 11244-55. PMID 19746468 DOI: 10.1002/chem.200901047  1
2009 Margulies D, Opatowsky Y, Fletcher S, Saraogi I, Tsou LK, Saha S, Lax I, Schlessinger J, Hamilton AD. Surface binding inhibitors of the SCF-KIT protein-protein interaction. Chembiochem : a European Journal of Chemical Biology. 10: 1955-8. PMID 19637142 DOI: 10.1002/cbic.200900079  1
2009 Saraogi I, Hamilton AD. Recent advances in the development of aryl-based foldamers. Chemical Society Reviews. 38: 1726-43. PMID 19587965 DOI: 10.1039/b819597h  1
2009 Margulies D, Hamilton AD. Digital analysis of protein properties by an ensemble of DNA quadruplexes. Journal of the American Chemical Society. 131: 9142-3. PMID 19566086 DOI: 10.1021/ja900848t  1
2009 Suryadevara PK, Olepu S, Lockman JW, Ohkanda J, Karimi M, Verlinde CL, Kraus JM, Schoepe J, Van Voorhis WC, Hamilton AD, Buckner FS, Gelb MH. Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. Journal of Medicinal Chemistry. 52: 3703-15. PMID 19463001 DOI: 10.1021/jm900030h  0.68
2009 Rodriguez JM, Ross NT, Katt WP, Dhar D, Lee GI, Hamilton AD. Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface. Chemmedchem. 4: 649-56. PMID 19330783 DOI: 10.1002/cmdc.200800387  1
2009 Wyrembak PN, Hamilton AD. Alkyne-linked 2,2-disubstituted-indolin-3-one oligomers as extended beta-strand mimetics. Journal of the American Chemical Society. 131: 4566-7. PMID 19284758 DOI: 10.1021/ja809245t  1
2009 Rosenzweig BA, Hamilton AD. Self-assembly of a four-helix bundle on a DNA quadruplex. Angewandte Chemie (International Ed. in English). 48: 2749-51. PMID 19267377 DOI: 10.1002/anie.200804849  1
2009 Rodriguez JM, Nevola L, Ross NT, Lee GI, Hamilton AD. Synthetic inhibitors of extended helix-protein interactions based on a biphenyl 4,4'-dicarboxamide scaffold. Chembiochem : a European Journal of Chemical Biology. 10: 829-33. PMID 19263447 DOI: 10.1002/cbic.200800715  1
2009 Hast MA, Fletcher S, Cummings CG, Pusateri EE, Blaskovich MA, Rivas K, Gelb MH, Van Voorhis WC, Sebti SM, Hamilton AD, Beese LS. Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chemistry & Biology. 16: 181-92. PMID 19246009 DOI: 10.1016/j.chembiol.2009.01.014  1
2009 Rosenzweig BA, Ross NT, Tagore DM, Jayawickramarajah J, Saraogi I, Hamilton AD. Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold. Journal of the American Chemical Society. 131: 5020-1. PMID 19226172 DOI: 10.1021/ja809219p  1
2009 Kazi A, Carie A, Blaskovich MA, Bucher C, Thai V, Moulder S, Peng H, Carrico D, Pusateri E, Pledger WJ, Berndt N, Hamilton A, Sebti SM. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Molecular and Cellular Biology. 29: 2254-63. PMID 19204084 DOI: 10.1128/MCB.01029-08  1
2009 Kayser-Bricker KJ, Glenn MP, Lee SH, Sebti SM, Cheng JQ, Hamilton AD. Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents. Bioorganic & Medicinal Chemistry. 17: 1764-71. PMID 19179081 DOI: 10.1016/j.bmc.2008.09.058  1
2009 Margulies D, Hamilton AD. Protein recognition by an ensemble of fluorescent DNA G-quadruplexes. Angewandte Chemie (International Ed. in English). 48: 1771-4. PMID 19173368 DOI: 10.1002/anie.200804887  1
2009 Cai J, Shapiro EM, Hamilton AD. Self-assembling DNA quadruplex conjugated to MRI contrast agents. Bioconjugate Chemistry. 20: 205-8. PMID 19125646 DOI: 10.1021/bc8004182  0.96
2009 Cai J, Rosenzweig BA, Hamilton AD. Inhibition of chymotrypsin by a self-assembled DNA quadruplex functionalized with cyclic peptide binding fragments. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 328-32. PMID 19053105 DOI: 10.1002/chem.200801637  1
2009 Cummings CG, Ross NT, Katt WP, Hamilton AD. Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic. Organic Letters. 11: 25-8. PMID 19035840 DOI: 10.1021/ol8022962  1
2009 Siddiquee KAZ, Gunning PT, Glenn M, Katt WP, Zhang S, Schrock C, Sebti SM, Jove R, Hamilton AD, Turkson J. An oxazole-based small-molecule stat3 inhibitor modulates stat3 stability and processing and induces antitumor cell effects (ACS Chemical Biology (2007) 2, (787-798)) Acs Chemical Biology. 4: 309. DOI: 10.1021/cb9000684  1
2009 Hamilton AD. Crown Ethers and Cryptands Comprehensive Heterocyclic Chemistry. 7: 731-761. DOI: 10.1016/B978-008096519-2.00127-2  1
2008 Saraogi I, Hamilton AD. alpha-Helix mimetics as inhibitors of protein-protein interactions. Biochemical Society Transactions. 36: 1414-7. PMID 19021566 DOI: 10.1042/BST0361414  1
2008 Gunning PT, Glenn MP, Siddiquee KA, Katt WP, Masson E, Sebti SM, Turkson J, Hamilton AD. Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders. Chembiochem : a European Journal of Chemical Biology. 9: 2800-3. PMID 19006150 DOI: 10.1002/cbic.200800291  1
2008 Saraogi I, Incarvito CD, Hamilton AD. Controlling curvature in a family of oligoamide alpha-helix mimetics. Angewandte Chemie (International Ed. in English). 47: 9691-4. PMID 18989875 DOI: 10.1002/anie.200803778  1
2008 Fletcher S, Cummings CG, Rivas K, Katt WP, Hornéy C, Buckner FS, Chakrabarti D, Sebti SM, Gelb MH, Van Voorhis WC, Hamilton AD. Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation. Journal of Medicinal Chemistry. 51: 5176-97. PMID 18686940 DOI: 10.1021/jm800113p  1
2008 Gustafsdottir SM, Wennström S, Fredriksson S, Schallmeiner E, Hamilton AD, Sebti SM, Landegren U. Use of proximity ligation to screen for inhibitors of interactions between vascular endothelial growth factor A and its receptors. Clinical Chemistry. 54: 1218-25. PMID 18499900 DOI: 10.1373/clinchem.2007.099424  1
2008 Tapriyal D, Wang Y, Enick RM, Johnson JK, Crosthwaite J, Thies MC, Paik IH, Hamilton AD. Poly(vinyl acetate), poly((1-O-(vinyloxy) ethyl-2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside) and amorphous poly(lactic acid) are the most CO2-soluble oxygenated hydrocarbon-based polymers Journal of Supercritical Fluids. 46: 252-257. DOI: 10.1016/j.supflu.2008.05.001  1
2008 Yin H, Hamilton AD. Controlling Protein-Protein Interactions: Protein Secondary Structure Mimetics as Modulators of Protein-Protein and Protein-Ligand Interactions Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 1: 250-269. DOI: 10.1002/9783527619375.ch4c  1
2007 Siddiquee KA, Gunning PT, Glenn M, Katt WP, Zhang S, Schrock C, Schroeck C, Sebti SM, Jove R, Hamilton AD, Turkson J. An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. Acs Chemical Biology. 2: 787-98. PMID 18154266 DOI: 10.1021/cb7001973  1
2007 Rodriguez JM, Hamilton AD. Benzoylurea oligomers: synthetic foldamers that mimic extended alpha helices. Angewandte Chemie (International Ed. in English). 46: 8614-7. PMID 17918270 DOI: 10.1002/anie.200701869  1
2007 Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Molecular and Cellular Biology. 27: 8003-14. PMID 17875936 DOI: 10.1128/MCB.00057-07  1
2007 Jayawickramarajah J, Tagore DM, Tsou LK, Hamilton AD. Allosteric control of self-assembly: modulating the formation of guanine quadruplexes through orthogonal aromatic interactions. Angewandte Chemie (International Ed. in English). 46: 7583-6. PMID 17823899 DOI: 10.1002/anie.200701883  1
2007 Van Voorhis WC, Rivas KL, Bendale P, Nallan L, Hornéy C, Barrett LK, Bauer KD, Smart BP, Ankala S, Hucke O, Verlinde CL, Chakrabarti D, Strickland C, Yokoyama K, Buckner FS, ... Hamilton AD, et al. Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase. Antimicrobial Agents and Chemotherapy. 51: 3659-71. PMID 17606674 DOI: 10.1128/AAC.00246-07  0.4
2007 Park KK, Park JW, Hamilton AD. Solvent and pH effects on the fluorescence of 7-(dimethylamino)-2-fluorenesulfonate. Journal of Fluorescence. 17: 361-9. PMID 17522966 DOI: 10.1007/s10895-007-0193-1  1
2007 Fletcher S, Hamilton AD. Protein-protein interaction inhibitors: small molecules from screening techniques. Current Topics in Medicinal Chemistry. 7: 922-7. PMID 17508923 DOI: 10.2174/156802607780906735  1
2007 Becerril J, Hamilton AD. Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides. Angewandte Chemie (International Ed. in English). 46: 4471-3. PMID 17487924 DOI: 10.1002/anie.200700657  1
2007 Paik IH, Tapriyal D, Enick RM, Hamilton AD. Fiber formation by highly CO2-soluble bisureas containing peracetylated carbohydrate groups. Angewandte Chemie (International Ed. in English). 46: 3284-7. PMID 17385779 DOI: 10.1002/anie.200604844  1
2007 Gunning PT, Katt WP, Glenn M, Siddiquee K, Siddique K, Kim JS, Jove R, Sebti SM, Turkson J, Hamilton AD. Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains. Bioorganic & Medicinal Chemistry Letters. 17: 1875-8. PMID 17336521 DOI: 10.1016/j.bmcl.2007.01.077  1
2007 Epifano F, Curini M, Genovese S, Blaskovich M, Hamilton A, Sebti SM. Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I Bioorganic and Medicinal Chemistry Letters. 17: 2639-2642. PMID 17314046 DOI: 10.1016/j.bmcl.2007.01.097  1
2007 Kayser KJ, Glenn MP, Sebti SM, Cheng JQ, Hamilton AD. Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics. Bioorganic & Medicinal Chemistry Letters. 17: 2068-73. PMID 17276059 DOI: 10.1016/j.bmcl.2007.01.004  1
2007 Stern E, Klemic JF, Routenberg DA, Wyrembak PN, Turner-Evans DB, Hamilton AD, LaVan DA, Fahmy TM, Reed MA. Label-free immunodetection with CMOS-compatible semiconducting nanowires. Nature. 445: 519-22. PMID 17268465 DOI: 10.1038/nature05498  1
2007 Davis JM, Tsou LK, Hamilton AD. Synthetic non-peptide mimetics of alpha-helices. Chemical Society Reviews. 36: 326-34. PMID 17264933 DOI: 10.1039/b608043j  1
2007 Wilson AJ, Hong J, Fletcher S, Hamilton AD. Recognition of solvent exposed protein surfaces using anthracene derived receptors. Organic & Biomolecular Chemistry. 5: 276-85. PMID 17205171 DOI: 10.1039/b612975g  0.76
2007 Tagore DM, Sprinz KI, Fletcher S, Jayawickramarajah J, Hamilton AD. Protein recognition and denaturation by self-assembling fragments on a DNA quadruplex scaffold. Angewandte Chemie (International Ed. in English). 46: 223-5. PMID 17136788 DOI: 10.1002/anie.200603479  1
2007 Delarue FL, Adnane J, Joshi B, Blaskovich MA, Wang DA, Hawker J, Bizouarn F, Ohkanda J, Zhu K, Hamilton AD, Chellappan S, Sebti SM. Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter. Oncogene. 26: 633-40. PMID 16909123 DOI: 10.1038/sj.onc.1209819  1
2007 Tagore DM, Sprinz KI, Hamilton AD. Duplex DNA as a self-assembling template for the identification of bidentate protein-binding agents Supramolecular Chemistry. 19: 129-136. DOI: 10.1080/10610270600990253  0.88
2007 Fletcher S, Hamilton AD. Denaturation and accelerated proteolysis of sizeable heme proteins by synthetic metalloporphyrins New Journal of Chemistry. 31: 623-627. DOI: 10.1039/b700123a  1
2007 Epifano F, Curini M, Genovese S, Blaskovich M, Hamilton A, Sebti SM. Corrigendum to "Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I" [Bioorg. Med. Chem. Lett. 17 (2007) 2639-2642] (DOI:10.1016/j.bmcl.2007.01.097) Bioorganic and Medicinal Chemistry Letters. 17: 5492. DOI: 10.1016/j.bmcl.2007.07.042  1
2007 Gunning PT, Katt WP, Glenn M, Siddiquee K, Kim JS, Jove R, Sebti SM, Turkson J, Hamilton AD. Corrigendum to "Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: Structural recognition of STAT SH2 domains" [Bioorg. Med. Chem. Lett. 17 (2007) 1875-1878] (DOI:10.1016/j.bmcl.2007.01.077) Bioorganic and Medicinal Chemistry Letters. 17: 2949. DOI: 10.1016/j.bmcl.2007.03.063  1
2007 Becerril J, Rodriguez JM, Saraogi I, Hamilton AD. Foldamer-based Molecular Recognition Foldamers: Structure, Properties, and Applications. 193-228. DOI: 10.1002/9783527611478.ch7  1
2006 Kim JT, Hamilton AD, Bailey CM, Domaoal RA, Domoal RA, Wang L, Anderson KS, Jorgensen WL. FEP-guided selection of bicyclic heterocycles in lead optimization for non-nucleoside inhibitors of HIV-1 reverse transcriptase. Journal of the American Chemical Society. 128: 15372-3. PMID 17131993 DOI: 10.1021/ja066472g  1
2006 Glenn MP, Chang SY, Hornéy C, Rivas K, Yokoyama K, Pusateri EE, Fletcher S, Cummings CG, Buckner FS, Pendyala PR, Chakrabarti D, Sebti SM, Gelb M, Van Voorhis WC, Hamilton AD. Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites. Journal of Medicinal Chemistry. 49: 5710-27. PMID 16970397 DOI: 10.1021/jm060081v  1
2006 Thakur VV, Kim JT, Hamilton AD, Bailey CM, Domaoal RA, Wang L, Anderson KS, Jorgensen WL. Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 16: 5664-7. PMID 16931015 DOI: 10.1016/j.bmcl.2006.08.037  1
2006 Fletcher S, Hamilton AD. Targeting protein-protein interactions by rational design: mimicry of protein surfaces. Journal of the Royal Society, Interface / the Royal Society. 3: 215-33. PMID 16849232 DOI: 10.1098/rsif.2006.0115  0.72
2006 Zhou H, Wang DA, Baldini L, Ennis E, Jain R, Carie A, Sebti SM, Hamilton AD. Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. Organic & Biomolecular Chemistry. 4: 2376-86. PMID 16763682 DOI: 10.1039/b515483a  1
2006 Tang D, Park HJ, Georgescu SP, Sebti SM, Hamilton AD, Galper JB. Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA. Life Sciences. 79: 1484-92. PMID 16740276 DOI: 10.1016/j.lfs.2006.04.019  1
2006 Peng H, Carrico D, Thai V, Blaskovich M, Bucher C, Pusateri EE, Sebti SM, Hamilton AD. Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I. Organic & Biomolecular Chemistry. 4: 1768-84. PMID 16633570 DOI: 10.1039/b517572k  1
2006 Kim IC, Hamilton AD. Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an alpha-helix. Organic Letters. 8: 1751-4. PMID 16623542 DOI: 10.1021/ol052956q  0.96
2006 Zhou H, Baldini L, Hong J, Wilson AJ, Hamilton AD. Pattern recognition of proteins based on an array of functionalized porphyrins. Journal of the American Chemical Society. 128: 2421-5. PMID 16478197 DOI: 10.1021/ja056833c  0.76
2006 Ohkanda J, Strickland CL, Blaskovich MA, Carrico D, Lockman JW, Vogt A, Bucher CJ, Sun J, Qian Y, Knowles D, Pusateri EE, Sebti SM, Hamilton AD. Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase. Organic & Biomolecular Chemistry. 4: 482-92. PMID 16446806 DOI: 10.1039/b508184j  1
2006 Anagnostopoulou A, Vultur A, Arulanandam R, Cao J, Turkson J, Jove R, Kim JS, Glenn M, Hamilton AD, Raptis L. Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells. Cancer Letters. 242: 120-32. PMID 16377083 DOI: 10.1016/j.canlet.2005.10.047  0.6
2006 Ruiz-Caro J, Basavapathruni A, Kim JT, Bailey CM, Wang L, Anderson KS, Hamilton AD, Jorgensen WL. Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 16: 668-71. PMID 16298131 DOI: 10.1016/j.bmcl.2005.10.037  1
2006 Jorgensen WL, Ruiz-Caro J, Tirado-Rives J, Basavapathruni A, Anderson KS, Hamilton AD. Computer-aided design of non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 16: 663-7. PMID 16263277 DOI: 10.1016/j.bmcl.2005.10.038  0.6
2006 Park KK, Tsou LK, Hamilton AD. Facile and selective aerobic oxidation of arylalkanes to aryl ketones using cesium carbonate Synthesis. 3617-3620. DOI: 10.1055/s-2006-950189  1
2006 Estroff LA, Hamilton AD. Cryo-tem, X-ray diffraction and modeling of an organic hydrogel Molecular Gels: Materials With Self-Assembled Fibrillar Networks. 721-742. DOI: 10.1007/1-4020-3689-2_21  1
2006 Yin H, Lee GI, Hamilton AD. Alpha-Helix Mimetics in Drug Discovery Drug Discovery Research: New Frontiers in the Post-Genomic Era. 281-299. DOI: 10.1002/9780470131862.ch11  1
2005 Guida WC, Hamilton AD, Crotty JW, Sebti SM. Protein farnesyltransferase: flexible docking studies on inhibitors using computational modeling. Journal of Computer-Aided Molecular Design. 19: 871-85. PMID 16607571 DOI: 10.1007/s10822-005-9030-2  1
2005 Davis JM, Truong A, Hamilton AD. Synthesis of a 2,3';6',3''-terpyridine scaffold as an alpha-helix mimetic. Organic Letters. 7: 5405-8. PMID 16288517 DOI: 10.1021/ol0521228  1
2005 Fletcher S, Hamilton AD. Protein surface recognition and proteomimetics: mimics of protein surface structure and function. Current Opinion in Chemical Biology. 9: 632-8. PMID 16242379 DOI: 10.1016/j.cbpa.2005.10.006  0.72
2005 Fan X, Potluri VK, McLeod MC, Wang Y, Liu J, Enick RM, Hamilton AD, Roberts CB, Johnson JK, Beckman EJ. Oxygenated hydrocarbon ionic surfactants exhibit CO2 solubility. Journal of the American Chemical Society. 127: 11754-62. PMID 16104753 DOI: 10.1021/ja052037v  1
2005 Yin H, Lee GI, Sedey KA, Kutzki O, Park HS, Orner BP, Ernst JT, Wang HG, Sebti SM, Hamilton AD. Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL. Journal of the American Chemical Society. 127: 10191-6. PMID 16028929 DOI: 10.1021/ja050122x  1
2005 Glenn MP, Chang SY, Hucke O, Verlinde CL, Rivas K, Hornéy C, Yokoyama K, Buckner FS, Pendyala PR, Chakrabarti D, Gelb M, Van Voorhis WC, Sebti SM, Hamilton AD. Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites. Angewandte Chemie (International Ed. in English). 44: 4903-6. PMID 16007716 DOI: 10.1002/anie.200500674  0.68
2005 Sprinz KI, Tagore DM, Hamilton AD. Self-assembly of bivalent protein-binding agents based on oligonucleotide-linked organic fragments. Bioorganic & Medicinal Chemistry Letters. 15: 3908-11. PMID 15993069 DOI: 10.1016/j.bmcl.2005.05.094  0.88
2005 Chen L, Yin H, Farooqi B, Sebti S, Hamilton AD, Chen J. p53 alpha-Helix mimetics antagonize p53/MDM2 interaction and activate p53. Molecular Cancer Therapeutics. 4: 1019-25. PMID 15956260 DOI: 10.1158/1535-7163.MCT-04-0342  0.92
2005 Yin H, Hamilton AD. Strategies for targeting protein-protein interactions with synthetic agents. Angewandte Chemie (International Ed. in English). 44: 4130-63. PMID 15954154 DOI: 10.1002/anie.200461786  0.92
2005 Nallan L, Bauer KD, Bendale P, Rivas K, Yokoyama K, Hornéy CP, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Hamilton A, Sebti S, Windsor WT, Weber PC, Buckner FS, et al. Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. Journal of Medicinal Chemistry. 48: 3704-13. PMID 15916422 DOI: 10.1021/jm0491039  1
2005 Sun J, Wang DA, Jain RK, Carie A, Paquette S, Ennis E, Blaskovich MA, Baldini L, Coppola D, Hamilton AD, Sebti SM. Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors. Oncogene. 24: 4701-9. PMID 15897913 DOI: 10.1038/sj.onc.1208391  1
2005 Lockman JW, Hamilton AD. Recent developments in the identification of chemotherapeutics for Chagas disease. Current Medicinal Chemistry. 12: 945-59. PMID 15853707 DOI: 10.2174/0929867053507289  1
2005 Yin H, Lee GI, Sedey KA, Rodriguez JM, Wang HG, Sebti SM, Hamilton AD. Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction. Journal of the American Chemical Society. 127: 5463-8. PMID 15826183 DOI: 10.1021/ja0446404  1
2005 Yin H, Lee GI, Park HS, Payne GA, Rodriguez JM, Sebti SM, Hamilton AD. Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction. Angewandte Chemie (International Ed. in English). 44: 2704-7. PMID 15765497 DOI: 10.1002/anie.200462316  1
2005 Zhu K, Gerbino E, Beaupre DM, Mackley PA, Muro-Cacho C, Beam C, Hamilton AD, Lichtenheld MG, Kerr WG, Dalton W, Alsina M, Sebti SM. Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells. Blood. 105: 4759-66. PMID 15728126 DOI: 10.1182/blood-2004-11-4307  1
2005 Carrico D, Blaskovich MA, Bucher CJ, Sebti SM, Hamilton AD. Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I. Bioorganic & Medicinal Chemistry. 13: 677-88. PMID 15653335 DOI: 10.1016/j.bmc.2004.10.053  1
2005 Magliery TJ, Wilson CG, Pan W, Mishler D, Ghosh I, Hamilton AD, Regan L. Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism. Journal of the American Chemical Society. 127: 146-57. PMID 15631464 DOI: 10.1021/ja046699g  1
2005 Woo JT, Nakagawa H, Krecic AM, Nagai K, Hamilton AD, Sebti SM, Stern PH. Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha). Biochemical Pharmacology. 69: 87-95. PMID 15588717 DOI: 10.1016/j.bcp.2004.08.036  1
2005 Jain RK, Tsou LK, Hamilton AD. Recognition of cytochrome C by tetraphenylporphyrin-based protein surface receptors Macrocyclic Chemistry: Current Trends and Future Perspectives. 267-275. DOI: 10.1007/1-4020-3687-6_17  1
2005 Hamilton AD, Tagore DM, Sprinz KI. Formation and Recognition Properties of Dynamic Combinatorial Libraries Functional Synthetic Receptors. 299-332. DOI: 10.1002/352760572X.ch6  0.88
2005 Schrader T, Hamilton AD. Preface Functional Synthetic Receptors. ix-x. DOI: 10.1002/352760572X  1
2004 Carrico D, Ohkanda J, Kendrick H, Yokoyama K, Blaskovich MA, Bucher CJ, Buckner FS, Van Voorhis WC, Chakrabarti D, Croft SL, Gelb MH, Sebti SM, Hamilton AD. In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability. Bioorganic & Medicinal Chemistry. 12: 6517-26. PMID 15556768 DOI: 10.1016/j.bmc.2004.09.020  1
2004 Groves K, Wilson AJ, Hamilton AD. Catalytic unfolding and proteolysis of cytochrome C induced by synthetic binding agents. Journal of the American Chemical Society. 126: 12833-42. PMID 15469279 DOI: 10.1021/ja0317731  0.76
2004 Yang L, Dan HC, Sun M, Liu Q, Sun XM, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Research. 64: 4394-9. PMID 15231645 DOI: 10.1158/0008-5472.CAN-04-0343  1
2004 Jain R, Ernst JT, Kutzki O, Park HS, Hamilton AD. Protein recognition using synthetic surface-targeted agents. Molecular Diversity. 8: 89-100. PMID 15209160 DOI: 10.1023/B:MODI.0000025652.55320.16  1
2004 Sun J, Blaskovich MA, Jain RK, Delarue F, Paris D, Brem S, Wotoczek-Obadia M, Lin Q, Coppola D, Choi K, Mullan M, Hamilton AD, Sebti SM. Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor. Cancer Research. 64: 3586-92. PMID 15150116 DOI: 10.1158/0008-5472.CAN-03-2673  1
2004 Baldini L, Wilson AJ, Hong J, Hamilton AD. Pattern-based detection of different proteins using an array of fluorescent protein surface receptors. Journal of the American Chemical Society. 126: 5656-7. PMID 15125644 DOI: 10.1021/ja039562j  0.76
2004 Liu Y, Hamilton A, Nagaraj A, Yan LL, Liu K, Lai YG, McPherson DD, Chandran KB. Alteration in fluid mechanics in porcine femoral arteries with atheroma development. Annals of Biomedical Engineering. 32: 544-54. PMID 15117028 DOI: 10.1023/B:ABME.0000019174.02192.ac  0.36
2004 Turkson J, Kim JS, Zhang S, Yuan J, Huang M, Glenn M, Haura E, Sebti S, Hamilton AD, Jove R. Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Molecular Cancer Therapeutics. 3: 261-9. PMID 15026546  0.6
2004 Estroff LA, Hamilton AD. Water gelation by small organic molecules. Chemical Reviews. 104: 1201-18. PMID 15008620 DOI: 10.1021/cr0302049  1
2004 Yin H, Hamilton AD. Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein. Bioorganic & Medicinal Chemistry Letters. 14: 1375-9. PMID 15006365 DOI: 10.1016/j.bmcl.2003.09.096  0.92
2004 Estroff LA, Addadi L, Weiner S, Hamilton AD. An organic hydrogel as a matrix for the growth of calcite crystals. Organic & Biomolecular Chemistry. 2: 137-41. PMID 14737673 DOI: 10.1039/b309731e  1
2004 Ohkanda J, Buckner FS, Lockman JW, Yokoyama K, Carrico D, Eastman R, de Luca-Fradley K, Davies W, Croft SL, Van Voorhis WC, Gelb MH, Sebti SM, Hamilton AD. Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. Journal of Medicinal Chemistry. 47: 432-45. PMID 14711313 DOI: 10.1021/jm030236o  1
2004 Estroff LA, Incarvito CD, Hamilton AD. Design of a synthetic foldamer that modifies the growth of calcite crystals. Journal of the American Chemical Society. 126: 2-3. PMID 14709030 DOI: 10.1021/ja037614z  1
2003 Zhu K, Hamilton AD, Sebti SM. Farnesyltransferase inhibitors as anticancer agents: current status. Current Opinion in Investigational Drugs (London, England : 2000). 4: 1428-35. PMID 14763128  1
2003 Estroff LA, Huang JS, Hamilton AD. Fiber formation in water by a mono-urea dicarboxylic acid. Chemical Communications (Cambridge, England). 2958-9. PMID 14703806  1
2003 Sun J, Ohkanda J, Coppola D, Yin H, Kothare M, Busciglio B, Hamilton AD, Sebti SM. Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice. Cancer Research. 63: 8922-9. PMID 14695209  1
2003 Ohkanda J, Blaskovich MA, Sebti SM, Hamilton AD. The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents. Progress in Cell Cycle Research. 5: 211-7. PMID 14593715  1
2003 Zhang Z, Wang Y, Lantry LE, Kastens E, Liu G, Hamilton AD, Sebti SM, Lubet RA, You M. Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf. Oncogene. 22: 6257-65. PMID 13679864 DOI: 10.1038/sj.onc.1206630  1
2003 Choi K, Hamilton AD. Rigid macrocyclic triamides as anion receptors: anion-dependent binding stoichiometries and 1H chemical shift changes. Journal of the American Chemical Society. 125: 10241-9. PMID 12926947 DOI: 10.1021/ja034563x  1
2003 Bordier BB, Ohkanda J, Liu P, Lee SY, Salazar FH, Marion PL, Ohashi K, Meuse L, Kay MA, Casey JL, Sebti SM, Hamilton AD, Glenn JS. In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus. The Journal of Clinical Investigation. 112: 407-14. PMID 12897208 DOI: 10.1172/JCI17704  1
2003 Wilson AJ, Groves K, Jain RK, Park HS, Hamilton AD. Directed denaturation: room temperature and stoichiometric unfolding of cytochrome C by a metalloporphyrin dimer. Journal of the American Chemical Society. 125: 4420-1. PMID 12683802 DOI: 10.1021/ja028574m  1
2003 Wang G, Hamilton AD. Low molecular weight organogelators for water. Chemical Communications (Cambridge, England). 310-1. PMID 12613587  0.6
2003 Bolick SC, Landowski TH, Boulware D, Oshiro MM, Ohkanda J, Hamilton AD, Sebti SM, Dalton WS. The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells. Leukemia. 17: 451-7. PMID 12592346 DOI: 10.1038/sj.leu.2402832  1
2003 Doisneau-Sixou SF, Cestac P, Chouini S, Carroll JS, Hamilton AD, Sebti SM, Poirot M, Balaguer P, Faye JC, Sutherland RL, Favre G. Contrasting effects of prenyltransferase inhibitors on estrogen-dependent cell cycle progression and estrogen receptor-mediated transcriptional activity in MCF-7 cells. Endocrinology. 144: 989-98. PMID 12586776 DOI: 10.1210/en.2002-220726  1
2003 Ernst JT, Becerril J, Park HS, Yin H, Hamilton AD. Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex. Angewandte Chemie (International Ed. in English). 42: 535-9. PMID 12569483 DOI: 10.1002/anie.200390154  1
2003 Mazzocca A, Giusti S, Hamilton AD, Sebti SM, Pantaleo P, Carloni V. Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver cancer cell lines. Molecular Pharmacology. 63: 159-66. PMID 12488548 DOI: 10.1124/mol.63.1.159  1
2003 Potluri VK, Hamilton AD, Karanikas CF, Bane SE, Xu J, Beckman EJ, Enick RM. The high CO2-solubility of per-acetylated α-, β-, and γ-cyclodextrin Fluid Phase Equilibria. 211: 211-217. DOI: 10.1016/S0378-3812(03)00206-1  1
2003 Estroff LA, Leiserowitz L, Addadi L, Weiner S, Hamilton AD. Characterization of an organic hydrogel: A cryo-transmission electron microscopy and X-ray diffraction study Advanced Materials. 15: 38-42. DOI: 10.1002/adma.200390004  1
2002 Allal C, Pradines A, Hamilton AD, Sebti SM, Favre G. Farnesylated RhoB prevents cell cycle arrest and actin cytoskeleton disruption caused by the geranylgeranyltransferase I inhibitor GGTI-298. Cell Cycle (Georgetown, Tex.). 1: 430-7. PMID 12548020  1
2002 Orner BP, Salvatella X, Sánchez Quesada J, De Mendoza J, Giralt E, Hamilton AD. De novo protein surface design: use of cation-pi interactions to enhance binding between an alpha-helical peptide and a cationic molecule in 50 % aqueous solution. Angewandte Chemie (International Ed. in English). 41: 117-9. PMID 12491457 DOI: 10.1002/1521-3773(20020104)41:1<117::AID-ANIE117>3.0.CO;2-J  1
2002 Ernst JT, Kutzki O, Debnath AK, Jiang S, Lu H, Hamilton AD. Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion. Angewandte Chemie (International Ed. in English). 41: 278-81. PMID 12491408 DOI: 10.1002/1521-3773(20020118)41:2<278::AID-ANIE278>3.0.CO;2-A  1
2002 Zhao Q, Ernst JT, Hamilton AD, Debnath AK, Jiang S. XTT formazan widely used to detect cell viability inhibits HIV type 1 infection in vitro by targeting gp41. Aids Research and Human Retroviruses. 18: 989-97. PMID 12396451 DOI: 10.1089/08892220260235353  1
2002 Kutzki O, Park HS, Ernst JT, Orner BP, Yin H, Hamilton AD. Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry. Journal of the American Chemical Society. 124: 11838-9. PMID 12358513 DOI: 10.1021/ja026861k  1
2002 Potluri VK, Xu J, Enick R, Beckman E, Hamilton AD. Peracetylated sugar derivatives show high solubility in liquid and supercritical carbon dioxide. Organic Letters. 4: 2333-5. PMID 12098240 DOI: 10.1021/ol026007y  1
2002 Crespo NC, Delarue F, Ohkanda J, Carrico D, Hamilton AD, Sebti SM. The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status. Cell Death and Differentiation. 9: 702-9. PMID 12058275 DOI: 10.1038/sj.cdd.4401023  1
2002 Wang G, Hamilton AD. Synthesis and self-assembling properties of polymerizable organogelators. Chemistry (Weinheim An Der Bergstrasse, Germany). 8: 1954-61. PMID 12007106 DOI: 10.1002/1521-3765(20020415)8:8<1954::AID-CHEM1954>3.0.CO;2-X  0.6
2002 Park HS, Lin Q, Hamilton AD. Modulation of protein-protein interactions by synthetic receptors: design of molecules that disrupt serine protease-proteinaceous inhibitor interaction. Proceedings of the National Academy of Sciences of the United States of America. 99: 5105-9. PMID 11959960 DOI: 10.1073/pnas.082675899  1
2002 Ohkanda J, Knowles DB, Blaskovich MA, Sebti SM, Hamilton AD. Inhibitors of protein farnesyltransferase as novel anticancer agents. Current Topics in Medicinal Chemistry. 2: 303-23. PMID 11944822  1
2002 Walters CE, Pryce G, Hankey DJ, Sebti SM, Hamilton AD, Baker D, Greenwood J, Adamson P. Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis. Journal of Immunology (Baltimore, Md. : 1950). 168: 4087-94. PMID 11937568  1
2002 Li X, Liu L, Tupper JC, Bannerman DD, Winn RK, Sebti SM, Hamilton AD, Harlan JM. Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells. The Journal of Biological Chemistry. 277: 15309-16. PMID 11839765 DOI: 10.1074/jbc.M201253200  1
2002 Ohkanda J, Lockman JW, Kothare MA, Qian Y, Blaskovich MA, Sebti SM, Hamilton AD. Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold. Journal of Medicinal Chemistry. 45: 177-88. PMID 11754590 DOI: 10.1021/jm0103099  1
2002 Jain RK, Hamilton AD. Designing Protein Denaturants: Synthetic Agents Induce Cytochromec Unfolding at Low Concentrations and Stoichiometries Angewandte Chemie International Edition. 41: 641-643. DOI: 10.1002/1521-3773(20020215)41:4<641::AID-ANIE641>3.0.CO;2-1  0.32
2001 Choi K, Hamilton AD. A Dual Channel Fluorescence Chemosensor for Anions Involving Intermolecular Excited State Proton Transfer. Angewandte Chemie (International Ed. in English). 40: 3912-3915. PMID 29712141 DOI: 10.1002/1521-3773(20011015)40:20<3912::AID-ANIE3912>3.0.CO;2-R  1
2001 Wei Y, McLendon GL, Hamilton AD, Case MA, Purring CB, Lin Q, Park HS, Lee CS, Yu T. Disruption of protein-protein interactions: design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase. Chemical Communications (Cambridge, England). 1580-1. PMID 12240391 DOI: 10.1039/B104142H  1
2001 Linton BR, Goodman MS, Fan E, van Arman SA, Hamilton AD. Thermodynamic aspects of dicarboxylate recognition by simple artificial receptors. The Journal of Organic Chemistry. 66: 7313-9. PMID 11681943 DOI: 10.1021/jo010413y  1
2001 Kucich U, Rosenbloom JC, Herrick DJ, Abrams WR, Hamilton AD, Sebti SM, Rosenbloom J. Signaling events required for transforming growth factor-beta stimulation of connective tissue growth factor expression by cultured human lung fibroblasts. Archives of Biochemistry and Biophysics. 395: 103-12. PMID 11673871 DOI: 10.1006/abbi.2001.2571  1
2001 Choi K, Hamilton AD. A Dual Channel Fluorescence Chemosensor for Anions Involving Intermolecular Excited State Proton Transfer We thank the National Institutes of Health for financial support of this work. Angewandte Chemie (International Ed. in English). 40: 3912-3915. PMID 11668574 DOI: 10.1002/1521-3773(20011015)40:20<3912::AID-ANIE3912>3.0.CO;2-R  1
2001 Turkson J, Ryan D, Kim JS, Zhang Y, Chen Z, Haura E, Laudano A, Sebti S, Hamilton AD, Jove R. Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. The Journal of Biological Chemistry. 276: 45443-55. PMID 11579100 DOI: 10.1074/jbc.M107527200  0.6
2001 Finder JD, Petrus JL, Hamilton A, Villavicencio RT, Pitt BR, Sebti SM. Signal transduction pathways of IL-1beta-mediated iNOS in pulmonary vascular smooth muscle cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 281: L816-23. PMID 11557585 DOI: 10.1152/AJPLUNG.2001.281.4.L816  1
2001 Hamuro Y, Hamilton AD. Functionalized oligoanthranilamides: modular and conformationally controlled scaffolds. Bioorganic & Medicinal Chemistry. 9: 2355-63. PMID 11553476  0.84
2001 Teng S, Sun J, Irby R, Hamilton AD, Sebti S, Yeatman TJ. v-Src transformation is mediated through farnesylated proteins. The Journal of Surgical Research. 99: 343-6. PMID 11469908 DOI: 10.1006/jsre.2001.6184  1
2001 Orner BP, Ernst JT, Hamilton AD. Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix. Journal of the American Chemical Society. 123: 5382-3. PMID 11457415 DOI: 10.1021/ja0025548  1
2001 Choi K, Hamilton AD. Selective anion binding by a macrocycle with convergent hydrogen bonding functionality. Journal of the American Chemical Society. 123: 2456-7. PMID 11456908  1
2001 Ohkanda J, Lockman JW, Yokoyama K, Gelb MH, Croft SL, Kendrick H, Harrell MI, Feagin JE, Blaskovich MA, Sebti SM, Hamilton AD. Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity. Bioorganic & Medicinal Chemistry Letters. 11: 761-4. PMID 11277514 DOI: 10.1016/S0960-894X(01)00055-5  1
2001 Sun J, Nam S, Lee CS, Li B, Coppola D, Hamilton AD, Dou QP, Sebti SM. CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice. Cancer Research. 61: 1280-4. PMID 11245420  1
2001 Crespo NC, Ohkanda J, Yen TJ, Hamilton AD, Sebti SM. The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells. The Journal of Biological Chemistry. 276: 16161-7. PMID 11154688 DOI: 10.1074/jbc.M006213200  1
2001 Orner BP, Hamilton AD. The guanidinium group in molecular recognition: Design and synthetic approaches Journal of Inclusion Phenomena. 41: 141-147. DOI: 10.1023/A:1014433715641  1
2001 Estroff LA, Hamilton AD. At the interface of organic and inorganic chemistry: Bioinspired synthesis of composite materials Chemistry of Materials. 13: 3227-3235. DOI: 10.1021/cm010110k  1
2001 Hamilton AD, Kirby AJ. Model systems - Artificial models of protein function Current Opinion in Chemical Biology. 5: 623-625. DOI: 10.1016/S1367-5931(01)00257-5  1
2000 Peczuh MW, Hamilton AD. Peptide and protein recognition by designed molecules. Chemical Reviews. 100: 2479-94. PMID 11749292 DOI: 10.1021/cr9900026  1
2000 Sebti SM, Hamilton AD. Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies. Oncogene. 19: 6584-93. PMID 11426643 DOI: 10.1038/sj.onc.1204146  1
2000 Sebti SM, Hamilton AD. Design of growth factor antagonists with antiangiogenic and antitumor properties. Oncogene. 19: 6566-73. PMID 11426641 DOI: 10.1038/sj.onc.1204121  1
2000 Adnane J, Bizouarn FA, Chen Z, Ohkanda J, Hamilton AD, Munoz-Antonia T, Sebti SM. Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta. Oncogene. 19: 5525-33. PMID 11114730 DOI: 10.1038/sj.onc.1203920  1
2000 Sebti SM, Hamilton AD. Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues. Expert Opinion On Investigational Drugs. 9: 2767-82. PMID 11093352 DOI: 10.1517/13543784.9.12.2767  1
2000 Estroff LA, Hamilton AD. Effective Gelation of Water Using a Series of Bis-urea Dicarboxylic Acids We thank the National Science Foundation (CHE9817240) for financial support of this work and Dr. James Eckert (Department of Geology, Yale University) for assistance with the electron microscopy. We also thank R. E. Meléndez for compound 1. Angewandte Chemie (International Ed. in English). 39: 3447-3450. PMID 11091385 DOI: 10.1002/1521-3773(20001002)39:19<3447::AID-ANIE3447>3.0.CO;2-X  1
2000 Sebti SM, Hamilton AD. Inhibition of Rho GTPases using protein geranylgeranyltransferase I inhibitors. Methods in Enzymology. 325: 381-8. PMID 11036620  1
2000 Wei S, Gilvary DL, Corliss BC, Sebti S, Sun J, Straus DB, Leibson PJ, Trapani JA, Hamilton AD, Weber MJ, Djeu JY. Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway. Journal of Immunology (Baltimore, Md. : 1950). 165: 3811-9. PMID 11034387  0.52
2000 Blaskovich MA, Lin Q, Delarue FL, Sun J, Park HS, Coppola D, Hamilton AD, Sebti SM. Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice. Nature Biotechnology. 18: 1065-70. PMID 11017044 DOI: 10.1038/80257  1
2000 Linton BR, Goodman MS, Hamilton AD. Nitronate anion recognition and modulation of ambident reactivity by hydrogen-bonding receptors. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 2449-55. PMID 10939746 DOI: 10.1002/1521-3765(20000703)6:13<2449::AID-CHEM2449>3.0.CO;2-9  1
2000 Cohen-Jonathan E, Muschel RJ, Gillies McKenna W, Evans SM, Cerniglia G, Mick R, Kusewitt D, Sebti SM, Hamilton AD, Oliff A, Kohl N, Gibbs JB, Bernhard EJ. Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS. Radiation Research. 154: 125-32. PMID 10931682  0.68
2000 Rosenbloom J, Saitta B, Gaidarova S, Sandorfi N, Rosenbloom JC, Abrams WR, Hamilton AD, Sebti SM, Kucich U, Jimenez SA. Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I. Arthritis and Rheumatism. 43: 1624-32. PMID 10902768 DOI: 10.1002/1529-0131(200007)43:7<1624::AID-ANR28>3.0.CO;2-E  1
2000 Allal C, Favre G, Couderc B, Salicio S, Sixou S, Hamilton AD, Sebti SM, Lajoie-Mazenc I, Pradines A. RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription. The Journal of Biological Chemistry. 275: 31001-8. PMID 10896672 DOI: 10.1074/jbc.M005264200  1
2000 Jain RK, Hamilton AD. Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold. Organic Letters. 2: 1721-3. PMID 10880210  0.96
2000 Linton BR, Carr AJ, Orner BP, Hamilton AD. A versatile one-Pot synthesis of 1,3-substituted guanidines from carbamoyl isothiocyanates The Journal of Organic Chemistry. 65: 1566-8. PMID 10814126  1
2000 Kucich U, Rosenbloom JC, Shen G, Abrams WR, Hamilton AD, Sebti SM, Rosenbloom J. TGF-beta1 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erk1/erk2. Archives of Biochemistry and Biophysics. 374: 313-24. PMID 10666313 DOI: 10.1006/abbi.1999.1625  1
2000 Carloni V, Pinzani M, Giusti S, Romanelli RG, Parola M, Bellomo G, Failli P, Hamilton AD, Sebti SM, Laffi G, Gentilini P. Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells. Hepatology (Baltimore, Md.). 31: 131-40. PMID 10613738 DOI: 10.1002/hep.510310121  1
2000 Lantry LE, Zhang Z, Yao R, Crist KA, Wang Y, Ohkanda J, Hamilton AD, Sebti SM, Lubet RA, You M. Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis. 21: 113-6. PMID 10607742  1
2000 Jiang K, Coppola D, Crespo NC, Nicosia SV, Hamilton AD, Sebti SM, Cheng JQ. The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis. Molecular and Cellular Biology. 20: 139-48. PMID 10594016  1
2000 Linton BR, Carr AJ, Orner BP, Hamilton AD. A versatile one-pot synthesis of 1,3-substituted guanidines from carbamoyl isothiocyanates Journal of Organic Chemistry. 65: 1566-1568. DOI: 10.1021/jo991458q  1
1999 Qian Y, Marugan JJ, Fossum RD, Vogt A, Sebti SM, Hamilton AD. Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors. Bioorganic & Medicinal Chemistry. 7: 3011-24. PMID 10658608 DOI: 10.1016/S0968-0896(99)00252-7  1
1999 Shi C, Huang Z, Kilic S, Xu J, Enick RM, Beckman EJ, Carr AJ, Melendez RE, Hamilton AD. The Gelation of CO(2): A Sustainable Route to the Creation of Microcellular Materials. Science (New York, N.Y.). 286: 1540-1543. PMID 10567255  0.72
1999 Liu L, Moesner P, Kovach NL, Bailey R, Hamilton AD, Sebti SM, Harlan JM. Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s). The Journal of Biological Chemistry. 274: 33334-40. PMID 10559211 DOI: 10.1074/jbc.274.47.33334  1
1999 Pollack IF, Bredel M, Erff M, Hamilton AD, Sebti SM. Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II--preclinical studies in a nude mouse model. Neurosurgery. 45: 1208-14; discussion . PMID 10549939 DOI: 10.1097/00006123-199911000-00039  1
1999 Mazet JL, Padieu M, Osman H, Maume G, Mailliet P, Dereu N, Hamilton AD, Lavelle F, Sebti SM, Maume BF. Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells. Febs Letters. 460: 235-40. PMID 10544242 DOI: 10.1016/S0014-5793(99)01355-1  1
1999 Cohen-Jonathan E, Toulas C, Ader I, Monteil S, Allal C, Bonnet J, Hamilton AD, Sebti SM, Daly-Schveitzer N, Favre G. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2- induced radioresistance in HeLa cells expressing wild-type RAS Radiation Research. 152: 404-411. PMID 10477917 DOI: 10.2307/3580225  1
1999 Vasudevan A, Qian Y, Vogt A, Blaskovich MA, Ohkanda J, Sebti SM, Hamilton AD. Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I Journal of Medicinal Chemistry. 42: 1333-1340. PMID 10212118 DOI: 10.1021/jm9900873  1
1999 Sun J, Qian Y, Chen Z, Marfurt J, Hamilton AD, Sebti SM. The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin- dependent kinase inhibitors: A potential mechanism for GGTI-298 antitumor activity Journal of Biological Chemistry. 274: 6930-6934. PMID 10066746 DOI: 10.1074/jbc.274.11.6930  1
1999 Zimmerman SC, Hamilton AD. Model systems Current Opinion in Chemical Biology. 3: 711-713. DOI: 10.1016/S1367-5931(99)00041-1  1
1998 Stark WW, Blaskovich MA, Johnson BA, Qian Y, Vasudevan A, Pitt B, Hamilton AD, Sebti SM, Davies P. Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 275: L55-L63. PMID 29592053 DOI: 10.1152/ajplung.1998.275.1.L55  0.68
1998 Lin Q, Park HS, Hamuro Y, Lee CS, Hamilton AD. Protein surface recognition by synthetic agents: design and structural requirements of a family of artificial receptors that bind to cytochrome c. Biopolymers. 47: 285-97. PMID 10036970 DOI: 10.1002/(SICI)1097-0282(1998)47:4<285::AID-BIP4>3.0.CO;2-C  1
1998 Sharma TA, Carr AJ, Davis RS, Reynolds IJ, Hamilton AD. Aromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor. Bioorganic & Medicinal Chemistry Letters. 8: 3459-64. PMID 9934452 DOI: 10.1016/S0960-894X(98)00631-3  1
1998 Adnane J, Bizouarn FA, Qian Y, Hamilton AD, Sebti SM. p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor β- and Sp1- responsive element: Involvement of the small GTPase RhoA Molecular and Cellular Biology. 18: 6962-6970. PMID 9819384 DOI: 10.1128/MCB.18.12.6962  1
1998 Kucich U, Rosenbloom JC, Shen G, Abrams WR, Blaskovich MA, Hamilton AD, Ohkanda J, Sebti SM, Rosenbloom J. Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-β-stimulated pathway leading to elastin mRNA stabilization Biochemical and Biophysical Research Communications. 252: 111-116. PMID 9813154 DOI: 10.1006/bbrc.1998.9544  1
1998 Bredel M, Pollack IF, Freund JM, Hamilton AD, Sebti SM. Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth Neurosurgery. 43: 124-132. PMID 9657198 DOI: 10.1097/00006123-199807000-00081  1
1998 Qian Y, Vogt A, Vasudevan A, Sebti SM, Hamilton AD. Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics Bioorganic and Medicinal Chemistry. 6: 293-299. PMID 9568283 DOI: 10.1016/S0968-0896(97)10040-2  1
1998 Sun J, Qian Y, Hamilton AD, Sebti SM. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in node mouse xenografts Oncogene. 16: 1467-1473. PMID 9525745 DOI: 10.1038/sj.onc.1201656  1
1998 Sebti SM, Hamilton AD. New approaches to anticancer drug design based on the inhibition of farnesyltransferase Drug Discovery Today. 3: 26-33. DOI: 10.1016/S1359-6446(97)01122-7  1
1997 Sebti SM, Hamilton AD. Anticancer activity of farnesyltransferase and geranylgeranyltransferase I inhibitors: prospects for drug development. Expert Opinion On Investigational Drugs. 6: 1711-4. PMID 15989575 DOI: 10.1517/13543784.6.11.1711  1
1997 Vogt A, Sun J, Qian Y, Hamilton AD, Sebti SM. The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SD11) in a p53-independent manner Journal of Biological Chemistry. 272: 27224-27229. PMID 9341167 DOI: 10.1074/jbc.272.43.27224  1
1997 Sebti SM, Hamilton AD. Inhibition of Ras prenylation: A novel approach to cancer chemotherapy Pharmacology and Therapeutics. 74: 103-114. PMID 9336018 DOI: 10.1016/S0163-7258(97)00014-4  1
1997 Lerner EC, Zhang TT, Knowles DB, Qian Y, Hamilton AD, Sebti SM. Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines Oncogene. 15: 1283-1288. PMID 9315095 DOI: 10.1038/sj.onc.1201296  1
1997 Albert JS, Peczuh MW, Hamilton AD. Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an α-helical confirmation Bioorganic and Medicinal Chemistry. 5: 1455-1467. PMID 9313852 DOI: 10.1016/S0968-0896(97)00086-2  1
1997 Qian Y, Sebti SM, Hamilton AD. Farnesyltransferase as a target for anticancer drug design Biopolymers. 43: 25-41. PMID 9174410 DOI: 10.1002/(SICI)1097-0282(1997)43:1<25::AID-BIP4>3.0.CO;2-2  1
1997 Finder JD, Litz JL, Blaskovich MA, McGuire TF, Qian Y, Hamilton AD, Davies P, Sebti SM. Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells. The Journal of Biological Chemistry. 272: 13484-8. PMID 9153192 DOI: 10.1074/jbc.272.21.13484  1
1997 Clark GJ, Kinch MS, Rogers-Graham K, Sebti SM, Hamilton AD, Der CJ. The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation Journal of Biological Chemistry. 272: 10608-10615. PMID 9099708 DOI: 10.1074/jbc.272.16.10608  1
1996 McGuire TF, Qian Y, Vogt A, Hamilton AD, Sebti SM. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation Journal of Biological Chemistry. 271: 27402-27407. PMID 8910319 DOI: 10.1074/jbc.271.44.27402  1
1996 Sebti SM, Hamilton AD. Rational design of Ras prenyltransferase inhibitors as potential anticancer drugs Biochemical Society Transactions. 24: 692-699. PMID 8878828 DOI: 10.1042/BST0240692  1
1996 Hopkins RB, Albert JS, Van Engen D, Hamilton AD. Synthesis and structure of chiral macrocycles containing 2,2'-bipyridine subunits Bioorganic and Medicinal Chemistry. 4: 1121-1128. PMID 8831984 DOI: 10.1016/0968-0896(96)00124-1  1
1996 Qian Y, Vogt A, Sebti SM, Hamilton AD. Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors Journal of Medicinal Chemistry. 39: 217-223. PMID 8568811 DOI: 10.1021/jm950414g  1
1995 Vogt A, Qian Y, Blaskovich MA, Fossum RD, Hamilton AD, Sebti SM. A non-peptide mimetic of Ras-CAAX: Selective inhibition of farnesyltransferase and Ras processing Journal of Biological Chemistry. 270: 660-664. PMID 7822292 DOI: 10.1074/jbc.270.2.660  1
1995 McGuire TF, Qian Y, Blaskovich MA, Fossum RD, Sun J, Marlowe T, Corey SJ, Wathen SP, Vogt A, Hamilton AD. CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase. Biochemical and Biophysical Research Communications. 214: 295-303. PMID 7669049 DOI: 10.1006/bbrc.1995.2287  1
1995 Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, Sebti SM. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes Journal of Biological Chemistry. 270: 26802-26806. PMID 7592920 DOI: 10.1074/jbc.270.45.26802  1
1995 Lernert EC, Qian Y, Hamilton AD, Sebti SM. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor Journal of Biological Chemistry. 270: 26770-26773. PMID 7592913 DOI: 10.1074/jbc.270.45.26770  1
1995 Sebti SM. Burkitt lymphoma daudi cells contain two distinct farnesyltransferases with different divalent cation requirements Biochemistry. 34: 12398-12403. PMID 7547984 DOI: 10.1021/BI00038A037  0.44
1995 Kauffmann RC, Qian Y, Vogt A, Sebti SM, Hamilton AD, Carthew RW. Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 92: 10919-23. PMID 7479910 DOI: 10.1073/pnas.92.24.10919  1
1995 Fan E, Yang J, Geib SJ, Stoner TC, Hopkins MD, Hamilton AD. Hydrogen-bonding control of molecular aggregation: Self-complementary subunits lead to rod-shaped structures in the solid state Journal of the Chemical Society, Chemical Communications. 1251-1252. DOI: 10.1039/C39950001251  1
1995 Albert JS, Goodman MS, Hamilton AD. Molecular recognition of proteins: Sequence-selective binding of aspartate pairs in helical peptides Journal of the American Chemical Society. 117: 1143-1144. DOI: 10.1021/ja00108a037  1
1994 Valenta JN, Dixon RP, Hamilton AD, Weber SG. Enhanced extraction of phenobarbital from serum with a designed artificial receptor. Analytical Chemistry. 66: 2397-403. PMID 8080112  0.64
1994 Qian Y, Blaskovich MA, Seong CM, Vogt A, Hamilton AD, Sebti SM. Peptidomimetic inhibitors of p21ras farnesyltransferase: Hydrophobic functionalization leads to disruption of p21ras membrane association in whole cells Bioorganic and Medicinal Chemistry Letters. 4: 2579-2584. DOI: 10.1016/S0960-894X(01)80287-0  1
1994 Fredericks J, Yang J, Geib SJ, Hamilton AD. Hydrogen bonding control of molecular self-assembly Proceedings of the Indian Academy of Sciences - Chemical Sciences. 106: 923-935. DOI: 10.1007/BF02841908  1
1993 Albert JS, Hamilton AD. Synthetic analogs of the ristocetin binding site: Neutral, multidentate receptors for carboxylate recognition Tetrahedron Letters. 34: 7363-7366. DOI: 10.1016/S0040-4039(00)60126-0  1
1992 Vicent C, Fan E, Hamilton AD. Molecular recognition: directed hydrogen bonding receptors for acylamino acid carboxylates Tetrahedron Letters. 33: 4269-4272. DOI: 10.1016/S0040-4039(00)74235-3  1
1986 Mann MJ, Pant N, Hamilton AD. A synthetic analogue of the carboxylate-binding pocket of vancomycin Journal of the Chemical Society, Chemical Communications. 158-160. DOI: 10.1039/C39860000158  1
1986 Hamilton A, Lehn JM, Sessler JL. Coreceptor molecules. Synthesis of metalloreceptors containing porphyrin subunits and formation of mixed substrate supermolecules by binding of organic substrates and of metal ions Journal of the American Chemical Society. 108: 5158-5167. DOI: 10.1021/ja00277a021  0.4
1984 Hamilton AD, Rubin HD, Bocarsly AB. Binuclear complexes of a covalently linked porphyrin-bipyridine ligand Journal of the American Chemical Society. 106: 7255-7257.  1
1980 Battersby AR, Hamilton AD, McDonald E, Mombelli L, Wong OH. Biosynthesis of porphyrins and related macrocycles. Part 13. Structure of the protoporphyrin isomer derived from coproporphyrinogen IV by the action of beef-liver coproporphyrinogenase: synthesis of protoporphyrin XIII. Journal of the Chemical Society. Perkin Transactions 1. 6: 1283-9. PMID 7190574  0.44
Show low-probability matches.