Kim David Janda - Publications

Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Medicinal chemistry

277 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Olson ME, Sugane T, Zhou B, Janda KD. Consequence of Hapten Stereochemistry: An Efficacious Methamphetamine Vaccine. Journal of the American Chemical Society. 141: 14089-14092. PMID 31479256 DOI: 10.1021/jacs.9b07294  0.52
2019 Tenney RD, Blake S, Bremer PT, Zhou B, Hwang CS, Poklis JL, Janda KD, Banks ML. Vaccine blunts fentanyl potency in male rhesus monkeys. Neuropharmacology. 107730. PMID 31369740 DOI: 10.1016/j.neuropharm.2019.107730  0.6
2019 Lin L, Olson ME, Eubanks LM, Janda KD. Strategies to Counteract Botulinum Neurotoxin A: Nature's Deadliest Biomolecule. Accounts of Chemical Research. PMID 31322847 DOI: 10.1021/acs.accounts.9b00261  0.8
2019 Smith LC, Bremer PT, Hwang CS, Zhou B, Ellis B, Hixon MS, Janda KD. Monoclonal Antibodies for Combating Synthetic Opioid Intoxication. Journal of the American Chemical Society. PMID 31187995 DOI: 10.1021/jacs.9b04872  0.64
2019 Hwang CS, Smith LC, Wenthur CJ, Ellis B, Zhou B, Janda KD. Heroin vaccine: Using titer, affinity, and antinociception as metrics when examining sex and strain differences. Vaccine. PMID 31176539 DOI: 10.1016/j.vaccine.2019.05.061  0.52
2019 Natori Y, Hwang CS, Lin L, Smith LC, Zhou B, Janda KD. A chemically contiguous hapten approach for a heroin-fentanyl vaccine. Beilstein Journal of Organic Chemistry. 15: 1020-1031. PMID 31164940 DOI: 10.3762/bjoc.15.100  0.52
2019 Townsend EA, Blake S, Faunce KE, Hwang CS, Natori Y, Zhou B, Bremer PT, Janda KD, Banks ML. Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31043682 DOI: 10.1038/s41386-019-0385-9  0.6
2019 Nguyen JD, Grant Y, Creehan KM, Hwang CS, Vandewater SA, Janda KD, Cole M, Taffe MA. Δ-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions. Neuropharmacology. PMID 30980837 DOI: 10.1016/j.neuropharm.2019.04.010  0.48
2019 Wang J, Merino DM, Light N, Murphy BL, Wang YD, Guo X, Hodges AP, Chau LQ, Liu KW, Dhall G, Asgharzadeh S, Kiehna EN, Shirey RJ, Janda KD, Taylor MD, et al. Myc and loss of p53 cooperate to drive formation of choroid plexus carcinoma. Cancer Research. PMID 30885981 DOI: 10.1158/0008-5472.CAN-18-2565  0.52
2019 Wenthur CJ, Gautam R, Zhou B, Vendruscolo LF, Leggio L, Janda KD. Ghrelin Receptor Influence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl-Ghrelin. Scientific Reports. 9: 1841. PMID 30755699 DOI: 10.1038/s41598-019-38549-z  0.56
2018 Olson ME, Eubanks LM, Janda KD. Chemical Interventions for the Opioid Crisis: Key Advances and Remaining Challenges. Journal of the American Chemical Society. PMID 30532973 DOI: 10.1021/jacs.8b09756  0.8
2018 Hwang CS, Ellis B, Zhou B, Janda KD. Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin. Bioorganic & Medicinal Chemistry. PMID 30497790 DOI: 10.1016/j.bmc.2018.11.027  0.52
2018 Smith LC, Lin L, Hwang CS, Zhou B, Kubitz DM, Wang H, Janda KD. Lateral Flow Assessment and Unanticipated Toxicity of Kratom. Chemical Research in Toxicology. PMID 30380840 DOI: 10.1021/acs.chemrestox.8b00218  0.52
2018 Kallupi M, Xue S, Zhou B, Janda KD, George O. An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse. Science Advances. 4: eaat4751. PMID 30345354 DOI: 10.1126/sciadv.aat4751  0.52
2018 Hwang CS, Smith LC, Natori Y, Ellis B, Zhou B, Janda KD. Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin. Acs Omega. 3: 11537-11543. PMID 30288464 DOI: 10.1021/acsomega.8b01478  0.52
2018 Shirey R, Globisch D, Eubanks LM, Hixon MS, Janda KD. Non-Invasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis. Acs Infectious Diseases. PMID 30141624 DOI: 10.1021/acsinfecdis.8b00163  0.8
2018 Jacob NT, Miranda PO, Shirey RJ, Gautam R, Zhou B, de Orbe Izquierdo ME, Hixon MS, Hart JR, Ueno L, Vogt PK, Janda KD. Synthetic molecules for disruption of the MYC protein-protein interface. Bioorganic & Medicinal Chemistry. PMID 30037753 DOI: 10.1016/j.bmc.2018.07.019  0.64
2018 Nguyen JD, Hwang CS, Grant Y, Janda KD, Taffe MA. Prophylactic vaccination protects against the development of oxycodone self-administration. Neuropharmacology. PMID 29936242 DOI: 10.1016/j.neuropharm.2018.06.026  0.48
2018 Tararina MA, Xue S, Smith LC, Muellers SN, Miranda PO, Janda KD, Allen KN. Crystallography Coupled with Kinetic Analysis Provide Mechanistic Underpinnings of a Nicotine-Degrading Enzyme. Biochemistry. PMID 29812904 DOI: 10.1021/acs.biochem.8b00384  0.4
2018 Kimishima A, Olson ME, Natori Y, Janda KD. Efficient Syntheses of Cocaine Vaccines and Their Evaluation. Acs Medicinal Chemistry Letters. 9: 411-416. PMID 29795751 DOI: 10.1021/acsmedchemlett.8b00051  0.48
2018 Hwang CS, Smith LC, Natori Y, Ellis B, Zhou B, Janda KD. An efficacious vaccine against heroin contaminated with fentanyl. Acs Chemical Neuroscience. PMID 29558798 DOI: 10.1021/acschemneuro.8b00079  0.52
2018 Hwang CS, Bremer PT, Wenthur CJ, Ho SO, Chiang S, Ellis B, Zhou B, Fujii G, Janda KD. Enhancing Efficacy and Stability of an Anti-Heroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality. Molecular Pharmaceutics. PMID 29420901 DOI: 10.1021/acs.molpharmaceut.7b00933  0.6
2018 Miranda PO, Cubitt B, Jacob NT, Janda KD, Carlos de la Torre J. Mining a Kröhnke Pyridine Library for Anti-Arenavirus Activity. Acs Infectious Diseases. PMID 29405696 DOI: 10.1021/acsinfecdis.7b00236  0.48
2018 Xue S, Kallupi M, Zhou B, Smith LC, Miranda PO, George O, Janda KD. An enzymatic advance in nicotine cessation therapy. Chemical Communications (Cambridge, England). PMID 29308799 DOI: 10.1039/c7cc09134f  0.52
2017 Kimishima A, Olson ME, Janda KD. Investigations into the efficacy of multi-component cocaine vaccines. Bioorganic & Medicinal Chemistry Letters. PMID 29317163 DOI: 10.1016/j.bmcl.2017.12.043  0.48
2017 Hwang CS, Janda KD. A Vision for Vaccines: Combating the Opioid Epidemic. Biochemistry. PMID 28994583 DOI: 10.1021/acs.biochem.7b00948  0.32
2017 Wenthur CJ, Zhou B, Janda KD. Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity. Nature. PMID 28813419 DOI: 10.1038/nature23464  0.52
2017 Wenthur CJ, Cai X, Ellis BA, Janda KD. Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric hapten design and combinatorial vaccination. Bioorganic & Medicinal Chemistry Letters. PMID 28709828 DOI: 10.1016/j.bmcl.2017.07.014  0.52
2017 Jacob NT, Anraku K, Kimishima A, Zhou B, Collins KC, Lockner JW, Ellis BA, Janda KD. A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior. Chemical Communications (Cambridge, England). PMID 28677711 DOI: 10.1039/c7cc04055e  0.64
2017 Bremer PT, Janda KD. Conjugate Vaccine Immunotherapy for Substance Use Disorder. Pharmacological Reviews. 69: 298-315. PMID 28634286 DOI: 10.1124/pr.117.013904  0.6
2017 Globisch D, Eubanks LM, Shirey RJ, Pfarr KM, Wanji S, Debrah AY, Hoerauf A, Janda KD. Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG). Bioorganic & Medicinal Chemistry Letters. PMID 28600214 DOI: 10.1016/j.bmcl.2017.05.082  0.8
2017 Bremer PT, Schlosburg JE, Banks ML, Steele FF, Zhou B, Poklis JL, Janda KD. Development of a Clinically-Viable Heroin Vaccine. Journal of the American Chemical Society. PMID 28574716 DOI: 10.1021/jacs.7b03334  0.64
2017 Bremer PT, Pellett S, Carolan JP, Tepp WH, Eubanks LM, Allen KN, Johnson EA, Janda KD. Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A. Journal of the American Chemical Society. PMID 28475321 DOI: 10.1021/jacs.7b01084  0.8
2017 Anraku K, Sato S, Jacob NT, Eubanks LM, Ellis BA, Janda KD. The design and synthesis of an α-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response. Organic & Biomolecular Chemistry. PMID 28294277 DOI: 10.1039/c7ob00448f  0.8
2017 Kimishima A, Wenthur CJ, Zhou B, Janda KD. An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life. Acs Chemical Biology. 12: 36-40. PMID 28103678 DOI: 10.1021/acschembio.6b00977  0.52
2016 Bremer PT, Adler M, Phung CH, Singh AK, Janda KD. Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based and Ex Vivo Assays. Journal of Medicinal Chemistry. PMID 27966961 DOI: 10.1021/acs.jmedchem.6b01393  0.6
2016 Gooyit MD, Miranda PO, Wenthur CJ, Ducime A, Janda KD. Influencing antibody-mediated attenuation of methamphetamine CNS distribution through vaccine linker design. Acs Chemical Neuroscience. PMID 27958709 DOI: 10.1021/acschemneuro.6b00389  1
2016 Nguyen JD, Bremer PT, Ducime A, Creehan KM, Kisby BR, Taffe MA, Janda KD. Active vaccination attenuates the psychostimulant effects of α-PVP and MDPV in rats. Neuropharmacology. PMID 27956054 DOI: 10.1016/j.neuropharm.2016.12.005  0.6
2016 Bremer PT, Xue S, Janda KD. Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain. Chemical Communications (Cambridge, England). PMID 27722252 DOI: 10.1039/c6cc06749b  0.6
2016 Kimishima A, Wenthur CJ, Eubanks LM, Sato S, Janda KD. Cocaine Vaccine Development: Evaluation of Carrier and Adjuvant Combinations that Activate Multiple Toll-like Receptors. Molecular Pharmaceutics. PMID 27717287 DOI: 10.1021/acs.molpharmaceut.6b00682  0.8
2016 Gooyit M, Janda KD. Reprofiled anthelmintics abate hypervirulent stationary-phase Clostridium difficile. Scientific Reports. 6: 33642. PMID 27633064 DOI: 10.1038/srep33642  1
2016 Gooyit MD, Janda KD. Modulation of the Surface-Layer Protein of Clostridium difficile through Cwp84 Inhibition. Acs Infectious Diseases. 2: 465-70. PMID 27626098 DOI: 10.1021/acsinfecdis.6b00061  1
2016 Zhou B, Eubanks LM, Jacob NT, Ellis B, Roberts AJ, Janda KD. Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose. Bioorganic & Medicinal Chemistry Letters. PMID 27599743 DOI: 10.1016/j.bmcl.2016.08.081  1
2016 Seki H, Xue S, Pellett S, Šilhár P, Johnson EA, Janda KD. Cellular protection of SNAP-25 against Botulinum Neurotoxin/A: Inhibition of thioredoxin reductase through a suicide substrate mechanism. Journal of the American Chemical Society. PMID 27070533 DOI: 10.1021/jacs.5b12929  1
2016 Collins KC, Schlosburg JE, Bremer PT, Janda KD. Methamphetamine Vaccines: Improvement through Hapten Design. Journal of Medicinal Chemistry. PMID 27054372 DOI: 10.1021/acs.jmedchem.6b00084  1
2016 Jacob NT, Lockner JW, Schlosburg JE, Ellis BA, Eubanks LM, Janda KD. Investigations of Enantiopure Nicotine Haptens using an Adjuvanting Carrier in Anti-Nicotine Vaccine Development. Journal of Medicinal Chemistry. PMID 26918428 DOI: 10.1021/acs.jmedchem.5b01676  1
2016 Tsuchikama K, Gooyit M, Harris TL, Zhu J, Globisch D, Kaufmann GF, Janda KD. Glycation Reactivity of a Quorum-Sensing Signaling Molecule. Angewandte Chemie (International Ed. in English). PMID 26890076 DOI: 10.1002/anie.201511911  1
2016 Bremer PT, Kimishima A, Schlosburg JE, Zhou B, Collins KC, Janda KD. Combatting Synthetic Designer Opioids: A Conjugate Vaccine Ablates Lethal Doses of Fentanyl Class Drugs. Angewandte Chemie (International Ed. in English). PMID 26879590 DOI: 10.1002/anie.201511654  0.64
2016 Hart JR, Weinberg MS, Morris KV, Roberts TC, Janda KD, Garner AL, Vogt PK. MINCR is not a MYC-induced lncRNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 26811502 DOI: 10.1073/pnas.1519903113  0.92
2015 Gooyit M, Harris TL, Tricoche N, Javor S, Lustigman S, Janda KD. Onchocerca volvulus Molting Inhibitors Identified through Scaffold Hopping. Acs Infectious Diseases. 1: 198-202. PMID 27622649 DOI: 10.1021/acsinfecdis.5b00017  1
2015 Collins KC, Tsuchikama K, Lowery CA, Zhu J, Janda KD. Dissecting AI-2-mediated quorum sensing through C5-analogue synthesis and biochemical analysis. Tetrahedron. 72: 3593-3598. PMID 27340303 DOI: 10.1016/j.tet.2015.08.063  0.68
2015 Globisch D, Specht S, Pfarr KM, Eubanks LM, Hoerauf A, Janda KD. Litomosoides sigmodontis: A jird urine metabolome study. Bioorganic & Medicinal Chemistry Letters. 25: 5804-7. PMID 26573416 DOI: 10.1016/j.bmcl.2015.10.037  1
2015 Xue S, Schlosburg JE, Janda KD. A New Strategy for Smoking Cessation: Characterization of a Bacterial Enzyme for the Degradation of Nicotine. Journal of the American Chemical Society. 137: 10136-9. PMID 26237398 DOI: 10.1021/jacs.5b06605  1
2015 Miller ML, Aarde SM, Moreno AY, Creehan KM, Janda KD, Taffe MA. Effects of active anti-methamphetamine vaccination on intravenous self-administration in rats. Drug and Alcohol Dependence. PMID 26118833 DOI: 10.1016/j.drugalcdep.2015.06.014  0.48
2015 Zhu J, Cai X, Harris TL, Gooyit M, Wood M, Lardy M, Janda KD. Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model. Chemistry & Biology. 22: 483-91. PMID 25892201 DOI: 10.1016/j.chembiol.2015.03.012  1
2015 Gooyit M, Tricoche N, Javor S, Lustigman S, Janda KD. Exploiting the Polypharmacology of ß-Carbolines to Disrupt O. volvulus Molting. Acs Medicinal Chemistry Letters. 6: 339-43. PMID 25815157 DOI: 10.1021/ml500516r  1
2015 Seki H, Xue S, Hixon MS, Pellett S, Remes M, Johnson EA, Janda KD. Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity. Chemical Communications (Cambridge, England). 51: 6226-9. PMID 25759983 DOI: 10.1039/c5cc00677e  1
2015 Lockner JW, Eubanks LM, Choi JL, Lively JM, Schlosburg JE, Collins KC, Globisch D, Rosenfeld-Gunn RJ, Wilson IA, Janda KD. Flagellin as carrier and adjuvant in cocaine vaccine development. Molecular Pharmaceutics. 12: 653-62. PMID 25531528 DOI: 10.1021/mp500520r  0.8
2015 Lockner JW, Lively JM, Collins KC, Vendruscolo JC, Azar MR, Janda KD. A conjugate vaccine using enantiopure hapten imparts superior nicotine-binding capacity. Journal of Medicinal Chemistry. 58: 1005-11. PMID 25493909 DOI: 10.1021/jm501625j  1
2015 Pippione AC, Dosio F, Ducime A, Federico A, Martina K, Sainas S, Frølund B, Gooyit M, Janda KD, Boschi D, Lolli ML. Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches Medchemcomm. 6: 1285-1292. DOI: 10.1039/c5md00182j  1
2015 Cai X, Globisch D, Thompson P, Lin J, Toader D, Dimasi N, Gao C, Janda KD. Corrigendum to "A chemoenzymatic approach toward the preparation of site-specific antibody-drug conjugates" [Tetrahedron Lett. 56 (2015) 3172-3175] Tetrahedron Letters. DOI: 10.1016/j.tetlet.2015.06.088  0.68
2015 Cai X, Janda KD. A chemoenzymatic approach toward the preparation of site-specific antibody-drug conjugates Tetrahedron Letters. 56: 3172-3175. DOI: 10.1016/j.tetlet.2014.12.025  1
2015 Collins KC, Tsuchikama K, Lowery CA, Zhu J, Janda KD. Dissecting AI-2-mediated quorum sensing through C5-analogue synthesis and biochemical analysis Tetrahedron. DOI: 10.1016/j.tet.2015.08.063  1
2014 Raffeiner P, Röck R, Schraffl A, Hartl M, Hart JR, Janda KD, Vogt PK, Stefan E, Bister K. In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential. Oncotarget. 5: 8869-78. PMID 25326649  1
2014 Xue S, Javor S, Hixon MS, Janda KD. Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity. Biochemistry. 53: 6820-4. PMID 25295706 DOI: 10.1021/bi500950x  1
2014 Eubanks LM, Ellis BA, Cai X, Schlosburg JE, Janda KD. A human recombinant monoclonal antibody to cocaine: Preparation, characterization and behavioral studies. Bioorganic & Medicinal Chemistry Letters. 24: 4664-6. PMID 25205191 DOI: 10.1016/j.bmcl.2014.08.035  1
2014 Hart JR, Garner AL, Yu J, Ito Y, Sun M, Ueno L, Rhee JK, Baksh MM, Stefan E, Hartl M, Bister K, Vogt PK, Janda KD. Inhibitor of MYC identified in a Kröhnke pyridine library. Proceedings of the National Academy of Sciences of the United States of America. 111: 12556-61. PMID 25114221 DOI: 10.1073/pnas.1319488111  1
2014 Harris TL, Lowery CA, Hixon MS, Janda KD. A platform stratifying a sequestering agent and a pharmacological antagonist as a means to negate botulinum neurotoxicity. Acs Chemical Neuroscience. 5: 632-6. PMID 25000171 DOI: 10.1021/cn500135h  1
2014 Bremer PT, Hixon MS, Janda KD. Benzoquinones as inhibitors of botulinum neurotoxin serotype A. Bioorganic & Medicinal Chemistry. 22: 3971-81. PMID 24984937 DOI: 10.1016/j.bmc.2014.06.004  1
2014 Gooyit M, Tricoche N, Lustigman S, Janda KD. Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting. Journal of Medicinal Chemistry. 57: 5792-9. PMID 24918716 DOI: 10.1021/jm5006435  1
2014 Jacob NT, Lockner JW, Kravchenko VV, Janda KD. Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL. Angewandte Chemie (International Ed. in English). 53: 6628-31. PMID 24838721 DOI: 10.1002/anie.201402133  1
2014 Hicks MJ, Kaminsky SM, De BP, Rosenberg JB, Evans SM, Foltin RW, Andrenyak DM, Moody DE, Koob GF, Janda KD, Ricart Arbona RJ, Lepherd ML, Crystal RG. Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine. Human Gene Therapy. Clinical Development. 25: 40-9. PMID 24649839 DOI: 10.1089/humc.2013.231  1
2014 Collins KC, Schlosburg JE, Lockner JW, Bremer PT, Ellis BA, Janda KD. Lipid tucaresol as an adjuvant for methamphetamine vaccine development. Chemical Communications (Cambridge, England). 50: 4079-81. PMID 24615284 DOI: 10.1039/c4cc00682h  1
2014 Hicks MJ, Kaminsky SM, De BP, Rosenberg JB, Evans SM, Foltin RW, Andrenyak DM, Moody DE, Koob GF, Janda KD, Ricart Arbona RJ, Lepherd M, Crystal RG. Fate of Systemically Administered Cocaine in Nonhuman Primates Treated with the dAd5GNE Anti-cocaine Vaccine. Human Gene Therapy. Clinical Development. PMID 24548017 DOI: 10.1089/hum.2013.231  0.88
2014 Collins KC, Janda KD. Investigating hapten clustering as a strategy to enhance vaccines against drugs of abuse. Bioconjugate Chemistry. 25: 593-600. PMID 24521489 DOI: 10.1021/bc500016k  1
2014 Bremer PT, Schlosburg JE, Lively JM, Janda KD. Injection route and TLR9 agonist addition significantly impact heroin vaccine efficacy. Molecular Pharmaceutics. 11: 1075-80. PMID 24517171 DOI: 10.1021/mp400631w  1
2014 Seki H, Pellett S, Silhár P, Stowe GN, Blanco B, Lardy MA, Johnson EA, Janda KD. Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain. Bioorganic & Medicinal Chemistry. 22: 1208-17. PMID 24360826 DOI: 10.1016/j.bmc.2013.11.053  1
2013 Lowery CA, Adler M, Borrell A, Janda KD. Scorpion toxins for the reversal of BoNT-induced paralysis. Bioorganic & Medicinal Chemistry Letters. 23: 6743-6. PMID 24252544 DOI: 10.1016/j.bmcl.2013.10.029  1
2013 Silhár P, Eubanks LM, Seki H, Pellett S, Javor S, Tepp WH, Johnson EA, Janda KD. Targeting botulinum A cellular toxicity: a prodrug approach. Journal of Medicinal Chemistry. 56: 7870-9. PMID 24127873 DOI: 10.1021/jm400873n  1
2013 Cai X, Whitfield T, Moreno AY, Grant Y, Hixon MS, Koob GF, Janda KD. Probing the effects of hapten stability on cocaine vaccine immunogenicity. Molecular Pharmaceutics. 10: 4176-84. PMID 23927436 DOI: 10.1021/mp400214w  1
2013 Lowery CA, Matamouros S, Niessen S, Zhu J, Scolnick J, Lively JM, Cravatt BF, Miller SI, Kaufmann GF, Janda KD. A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level. Chemistry & Biology. 20: 903-11. PMID 23890008 DOI: 10.1016/j.chembiol.2013.05.009  1
2013 Garner AL, Kim SK, Zhu J, Struss AK, Watkins R, Feske BD, Kaufmann GF, Janda KD. Retraction: Stereochemical insignificance discovered in Acinetobacter baumannii quorum sensing (PLoS ONE) Plos One. 8. PMID 23853689 DOI: 10.1371/annotation/1345f9b0-016e-4123-9e72-6ccc4fa17ba2  1
2013 Garner AL, Fullagar JL, Day JA, Cohen SM, Janda KD. Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors. Journal of the American Chemical Society. 135: 10014-7. PMID 23808771 DOI: 10.1021/ja404180x  1
2013 Zhu J, Hixon MS, Globisch D, Kaufmann GF, Janda KD. Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation. Journal of the American Chemical Society. 135: 7827-30. PMID 23672516 DOI: 10.1021/ja4024989  1
2013 Maoz A, Hicks MJ, Vallabhjosula S, Synan M, Kothari PJ, Dyke JP, Ballon DJ, Kaminsky SM, De BP, Rosenberg JB, Martinez D, Koob GF, Janda KD, Crystal RG. Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2170-8. PMID 23660705 DOI: 10.1038/npp.2013.114  1
2013 Schlosburg JE, Vendruscolo LF, Bremer PT, Lockner JW, Wade CL, Nunes AA, Stowe GN, Edwards S, Janda KD, Koob GF. Dynamic vaccine blocks relapse to compulsive intake of heroin. Proceedings of the National Academy of Sciences of the United States of America. 110: 9036-41. PMID 23650354 DOI: 10.1073/pnas.1219159110  1
2013 Cai X, Whitfield T, Hixon MS, Grant Y, Koob GF, Janda KD. Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design. Journal of Medicinal Chemistry. 56: 3701-9. PMID 23627877 DOI: 10.1021/jm400228w  1
2013 Matyas GR, Mayorov AV, Rice KC, Jacobson AE, Cheng K, Iyer MR, Li F, Beck Z, Janda KD, Alving CR. Liposomes containing monophosphoryl lipid A: a potent adjuvant system for inducing antibodies to heroin hapten analogs. Vaccine. 31: 2804-10. PMID 23624097 DOI: 10.1016/j.vaccine.2013.04.027  1
2013 Rosenberg JB, De BP, Hicks MJ, Janda KD, Kaminsky SM, Worgall S, Crystal RG. Suppression of nicotine-induced pathophysiology by an adenovirus hexon-based antinicotine vaccine. Human Gene Therapy. 24: 595-603. PMID 23611296 DOI: 10.1089/hum.2012.245  1
2013 Silhár P, Lardy MA, Hixon MS, Shoemaker CB, Barbieri JT, Struss AK, Lively JM, Javor S, Janda KD. The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft. Acs Medicinal Chemistry Letters. 4: 283-287. PMID 23565325 DOI: 10.1021/ml300428s  1
2013 Kravchenko V, Garner AL, Mathison J, Seit-Nebi A, Yu J, Gileva IP, Ulevitch R, Janda KD. Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones. Acs Chemical Biology. 8: 1117-20. PMID 23517377 DOI: 10.1021/cb4000184  1
2013 Fullagar JL, Garner AL, Struss AK, Day JA, Martin DP, Yu J, Cai X, Janda KD, Cohen SM. Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase. Chemical Communications (Cambridge, England). 49: 3197-9. PMID 23482955 DOI: 10.1039/c3cc41191e  1
2013 Globisch D, Moreno AY, Hixon MS, Nunes AA, Denery JR, Specht S, Hoerauf A, Janda KD. Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness. Proceedings of the National Academy of Sciences of the United States of America. 110: 4218-23. PMID 23440222 DOI: 10.1073/pnas.1221969110  1
2013 Cai X, Tsuchikama K, Janda KD. Modulating cocaine vaccine potency through hapten fluorination. Journal of the American Chemical Society. 135: 2971-4. PMID 23398531 DOI: 10.1021/ja400356g  1
2013 Struss AK, Nunes A, Waalen J, Lowery CA, Pullanikat P, Denery JR, Conrad DJ, Kaufmann GF, Janda KD. Toward implementation of quorum sensing autoinducers as biomarkers for infectious disease states. Analytical Chemistry. 85: 3355-62. PMID 23391272 DOI: 10.1021/ac400032a  1
2013 Å ilhár P, Silvaggi NR, Pellett S, ÄŒapková K, Johnson EA, Allen KN, Janda KD. Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies. Bioorganic & Medicinal Chemistry. 21: 1344-8. PMID 23340139 DOI: 10.1016/j.bmc.2012.12.001  1
2013 Garner AL, Yu J, Struss AK, Kaufmann GF, Kravchenko VV, Janda KD. Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development. Chemical Communications (Cambridge, England). 49: 1515-7. PMID 23328974 DOI: 10.1039/c3cc38851d  1
2013 Lockner JW, Ho SO, McCague KC, Chiang SM, Do TQ, Fujii G, Janda KD. Enhancing nicotine vaccine immunogenicity with liposomes. Bioorganic & Medicinal Chemistry Letters. 23: 975-8. PMID 23313243 DOI: 10.1016/j.bmcl.2012.12.048  1
2013 De BP, Pagovich OE, Hicks MJ, Rosenberg JB, Moreno AY, Janda KD, Koob GF, Worgall S, Kaminsky SM, Sondhi D, Crystal RG. Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity. Human Gene Therapy. 24: 58-66. PMID 23140508 DOI: 10.1089/hum.2012.163  1
2013 Miller ML, Moreno AY, Aarde SM, Creehan KM, Vandewater SA, Vaillancourt BD, Wright MJ, Janda KD, Taffe MA. A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats. Biological Psychiatry. 73: 721-8. PMID 23098894 DOI: 10.1016/j.biopsych.2012.09.010  1
2012 Garner AL, Struss AK, Fullagar JL, Agrawal A, Moreno AY, Cohen SM, Janda KD. 3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB. Acs Medicinal Chemistry Letters. 3: 668-672. PMID 23181168 DOI: 10.1021/ml300128f  1
2012 Bremer PT, Janda KD. Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance. Journal of Medicinal Chemistry. 55: 10776-80. PMID 23134263 DOI: 10.1021/jm301262z  1
2012 von Hoven G, Kloft N, Neukirch C, Ebinger S, Bobkiewicz W, Weis S, Boller K, Janda KD, Husmann M. Modulation of translation and induction of autophagy by bacterial exoproducts. Medical Microbiology and Immunology. 201: 409-18. PMID 22991039 DOI: 10.1007/s00430-012-0271-0  1
2012 Moreno AY, Azar MR, Koob GF, Janda KD. Probing the protective effects of a conformationally constrained nicotine vaccine. Vaccine. 30: 6665-70. PMID 22963803 DOI: 10.1016/j.vaccine.2012.08.064  1
2012 Tsuchikama K, Zhu J, Lowery CA, Kaufmann GF, Janda KD. C4-alkoxy-HPD: a potent class of synthetic modulators surpassing nature in AI-2 quorum sensing. Journal of the American Chemical Society. 134: 13562-4. PMID 22866957 DOI: 10.1021/ja305532y  1
2012 Hicks MJ, Rosenberg JB, De BP, Pagovich OE, Young CN, Qiu JP, Kaminsky SM, Hackett NR, Worgall S, Janda KD, Davisson RL, Crystal RG. AAV-directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation. Science Translational Medicine. 4: 140ra87. PMID 22745437 DOI: 10.1126/scitranslmed.3003611  1
2012 Garner AL, Kim SK, Zhu J, Struss AK, Watkins R, Feske BD, Kaufmann GF, Janda KD. Stereochemical insignificance discovered in Acinetobacter baumannii quorum sensing. Plos One. 7: e37102. PMID 22629354 DOI: 10.1371/journal.pone.0037102  1
2012 Rosenberg JB, Hicks MJ, De BP, Pagovich O, Frenk E, Janda KD, Wee S, Koob GF, Hackett NR, Kaminsky SM, Worgall S, Tignor N, Mezey JG, Crystal RG. AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior. Human Gene Therapy. 23: 451-9. PMID 22486244 DOI: 10.1089/hum.2011.178  1
2012 Treweek JB, Janda KD. An antidote for acute cocaine toxicity. Molecular Pharmaceutics. 9: 969-78. PMID 22380623 DOI: 10.1021/mp200588v  1
2012 Globisch D, Lowery CA, McCague KC, Janda KD. Uncharacterized 4,5-dihydroxy-2,3-pentanedione (DPD) molecules revealed through NMR spectroscopy: implications for a greater signaling diversity in bacterial species. Angewandte Chemie (International Ed. in English). 51: 4204-8. PMID 22378693 DOI: 10.1002/anie.201109149  1
2012 Kravchenko VV, Gloeckner C, Stowe GN, Kang YJ, Tobias PS, Mathison JC, Ulevitch RJ, Kaufmann GF, Janda KD. The use of small molecule probes to study spatially separated stimulus-induced signaling pathways. Bioorganic & Medicinal Chemistry Letters. 22: 2043-5. PMID 22300658 DOI: 10.1016/j.bmcl.2012.01.024  1
2012 Romano AA, Hahn T, Davis N, Lowery CA, Struss AK, Janda KD, Böttger LH, Matzanke BF, Carrano CJ. The Fe(III) and Ga(III) coordination chemistry of 3-(1-hydroxymethylidene) and 3-(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione: novel tetramic acid degradation products of homoserine lactone bacterial quorum sensing molecules. Journal of Inorganic Biochemistry. 107: 96-103. PMID 22178671 DOI: 10.1016/j.jinorgbio.2011.10.009  1
2012 Janda KD, Treweek JB. Vaccines targeting drugs of abuse: is the glass half-empty or half-full? Nature Reviews. Immunology. 12: 67-72. PMID 22173478 DOI: 10.1038/nri3130  1
2012 Zakhari JS, Zorrilla EP, Zhou B, Mayorov AV, Janda KD. Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice. Molecular Pharmaceutics. 9: 281-9. PMID 22149064 DOI: 10.1021/mp200376c  1
2012 Wee S, Hicks MJ, De BP, Rosenberg JB, Moreno AY, Kaminsky SM, Janda KD, Crystal RG, Koob GF. Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1083-91. PMID 21918504 DOI: 10.1038/npp.2011.200  1
2011 Koob G, Hicks MJ, Wee S, Rosenberg JB, De BP, Kaminsky SM, Moreno A, Janda KD, Crystal RG. Anti-cocaine vaccine based on coupling a cocaine analog to a disrupted adenovirus. Cns & Neurological Disorders Drug Targets. 10: 899-904. PMID 22229312  1
2011 Stowe GN, Schlosburg JE, Vendruscolo LF, Edwards S, Misra KK, Schulteis G, Zakhari JS, Koob GF, Janda KD. Developing a vaccine against multiple psychoactive targets: a case study of heroin. Cns & Neurological Disorders Drug Targets. 10: 865-75. PMID 22229311  1
2011 Hoon S, Zhou B, Janda KD, Brenner S, Scolnick J. Aptamer selection by high-throughput sequencing and informatic analysis. Biotechniques. 51: 413-6. PMID 22150332 DOI: 10.2144/000113786  1
2011 Li Z, Garner AL, Gloeckner C, Janda KD, Carlow CK. Targeting the Wolbachia cell division protein FtsZ as a new approach for antifilarial therapy. Plos Neglected Tropical Diseases. 5: e1411. PMID 22140592 DOI: 10.1371/journal.pntd.0001411  1
2011 Moreno AY, Janda KD. Current challenges for the creation of effective vaccines against drugs of abuse. Expert Review of Vaccines. 10: 1637-9. PMID 22085165 DOI: 10.1586/erv.11.145  1
2011 Zakhari JS, Kinoyama I, Hixon MS, Di Mola A, Globisch D, Janda KD. Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization. Bioorganic & Medicinal Chemistry. 19: 6203-9. PMID 21975066 DOI: 10.1016/j.bmc.2011.09.019  1
2011 Eubanks LM, Stowe GN, De Lamo Marin S, Mayorov AV, Hixon MS, Janda KD. Identification of α2 macroglobulin as a major serum ghrelin esterase. Angewandte Chemie (International Ed. in English). 50: 10699-702. PMID 21928452 DOI: 10.1002/anie.201104512  1
2011 Garner AL, Park J, Zakhari JS, Lowery CA, Struss AK, Sawada D, Kaufmann GF, Janda KD. A multivalent probe for AI-2 quorum-sensing receptors. Journal of the American Chemical Society. 133: 15934-7. PMID 21913711 DOI: 10.1021/ja207556d  1
2011 Liu Y, Jiang P, Capkova K, Xue D, Ye L, Sinha SC, Mackman N, Janda KD, Liu C. Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy. Cancer Research. 71: 6492-502. PMID 21880589 DOI: 10.1158/0008-5472.CAN-11-1145  1
2011 Stowe GN, Vendruscolo LF, Edwards S, Schlosburg JE, Misra KK, Schulteis G, Mayorov AV, Zakhari JS, Koob GF, Janda KD. A vaccine strategy that induces protective immunity against heroin. Journal of Medicinal Chemistry. 54: 5195-204. PMID 21692508 DOI: 10.1021/jm200461m  1
2011 Tsuchikama K, Lowery CA, Janda KD. Probing autoinducer-2 based quorum sensing: the biological consequences of molecules unable to traverse equilibrium states. The Journal of Organic Chemistry. 76: 6981-9. PMID 21678949 DOI: 10.1021/jo200882k  1
2011 Garner AL, Janda KD. A small molecule antagonist of ghrelin O-acyltransferase (GOAT). Chemical Communications (Cambridge, England). 47: 7512-4. PMID 21594284 DOI: 10.1039/c1cc11817j  1
2011 Garner AL, Gloeckner C, Tricoche N, Zakhari JS, Samje M, Cho-Ngwa F, Lustigman S, Janda KD. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. Journal of Medicinal Chemistry. 54: 3963-72. PMID 21534605 DOI: 10.1021/jm200364n  1
2011 Uckun FM, Qazi S, Ozer Z, Garner AL, Pitt J, Ma H, Janda KD. Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network. British Journal of Haematology. 153: 741-52. PMID 21517817 DOI: 10.1111/j.1365-2141.2011.08671.x  1
2011 Stowe GN, Janda KD. A Diels-Alder Reaction Conducted Within the Parameters of Aqueous Organocatalysis: Still Just Smoke and Mirrors. Tetrahedron Letters. 52: 2085-2087. PMID 21516231 DOI: 10.1016/j.tetlet.2010.10.134  1
2011 Moreno AY, Mayorov AV, Janda KD. Impact of distinct chemical structures for the development of a methamphetamine vaccine. Journal of the American Chemical Society. 133: 6587-95. PMID 21473576 DOI: 10.1021/ja108807j  1
2011 Kirchdoerfer RN, Garner AL, Flack CE, Mee JM, Horswill AR, Janda KD, Kaufmann GF, Wilson IA. Structural basis for ligand recognition and discrimination of a quorum-quenching antibody. The Journal of Biological Chemistry. 286: 17351-8. PMID 21454495 DOI: 10.1074/jbc.M111.231258  1
2011 Šilhár P, Alakurtti S, ?apková K, Xiaochuan F, Shoemaker CB, Yli-Kauhaluoma J, Janda KD. Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease. Bioorganic & Medicinal Chemistry Letters. 21: 2229-31. PMID 21421315 DOI: 10.1016/j.bmcl.2011.02.115  1
2011 Treweek JB, Roberts AJ, Janda KD. Immunopharmacotherapeutic manifolds and modulation of cocaine overdose. Pharmacology, Biochemistry, and Behavior. 98: 474-84. PMID 21356233 DOI: 10.1016/j.pbb.2011.02.020  1
2011 Zakhari JS, Kinoyama I, Struss AK, Pullanikat P, Lowery CA, Lardy M, Janda KD. Synthesis and molecular modeling provide insight into a Pseudomonas aeruginosa quorum sensing conundrum. Journal of the American Chemical Society. 133: 3840-2. PMID 21348514 DOI: 10.1021/ja111138y  1
2011 Garner AL, Janda KD. Protein-protein interactions and cancer: targeting the central dogma. Current Topics in Medicinal Chemistry. 11: 258-80. PMID 21320057 DOI: 10.2174/156802611794072614  1
2011 Garner AL, Janda KD. Shedding light on the ghrelin/GOAT metabolism saga. Chembiochem : a European Journal of Chemical Biology. 12: 523-5. PMID 21254317 DOI: 10.1002/cbic.201000777  1
2011 Hicks MJ, De BP, Rosenberg JB, Davidson JT, Moreno AY, Janda KD, Wee S, Koob GF, Hackett NR, Kaminsky SM, Worgall S, Toth M, Mezey JG, Crystal RG. Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 612-9. PMID 21206484 DOI: 10.1038/mt.2010.280  1
2011 Salzameda NT, Eubanks LM, Zakhari JS, Tsuchikama K, DeNunzio NJ, Allen KN, Hixon MS, Janda KD. A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action. Chemical Communications (Cambridge, England). 47: 1713-5. PMID 21203627 DOI: 10.1039/c0cc04078a  1
2011 Garner AL, Yu J, Struss AK, Lowery CA, Zhu J, Kim SK, Park J, Mayorov AV, Kaufmann GF, Kravchenko VV, Janda KD. Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: unanticipated effects on mammalian cell activation. Bioorganic & Medicinal Chemistry Letters. 21: 2702-5. PMID 21190852 DOI: 10.1016/j.bmcl.2010.11.122  1
2011 Pier CL, Chen C, Tepp WH, Lin G, Janda KD, Barbieri JT, Pellett S, Johnson EA. Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1. Febs Letters. 585: 199-206. PMID 21126520 DOI: 10.1016/j.febslet.2010.11.045  1
2011 Kaufmann GF, Park J, Mayorov AV, Kubitz DM, Janda KD. Generation of quorum quenching antibodies. Methods in Molecular Biology (Clifton, N.J.). 692: 299-311. PMID 21031321 DOI: 10.1007/978-1-60761-971-0_22  1
2011 Lowery CA, Kaufmann GF, Janda KD. Determination of acyl homoserine lactone and tetramic acid concentrations in biological samples. Methods in Molecular Biology (Clifton, N.J.). 692: 101-11. PMID 21031307 DOI: 10.1007/978-1-60761-971-0_8  1
2011 Janda KD. Bioorganic and Medicinal Chemistry: Editor's note Bioorganic and Medicinal Chemistry. 19: 20. DOI: 10.1016/j.bmc.2010.12.040  1
2010 Eubanks LM, Silhár P, Salzameda NT, Zakhari JS, Xiaochuan F, Barbieri JT, Shoemaker CB, Hixon MS, Janda KD. Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease. Acs Medicinal Chemistry Letters. 1: 268-272. PMID 20959871 DOI: 10.1021/ml100074s  1
2010 Denery JR, Nunes AA, Hixon MS, Dickerson TJ, Janda KD. Metabolomics-based discovery of diagnostic biomarkers for onchocerciasis. Plos Neglected Tropical Diseases. 4. PMID 20957145 DOI: 10.1371/journal.pntd.0000834  1
2010 Mayorov AV, Willis B, Di Mola A, Adler D, Borgia J, Jackson O, Wang J, Luo Y, Tang L, Knapp RJ, Natarajan C, Goodnough MC, Zilberberg N, Simpson LL, Janda KD. Symptomatic relief of botulinum neurotoxin/a intoxication with aminopyridines: a new twist on an old molecule. Acs Chemical Biology. 5: 1183-91. PMID 20936877 DOI: 10.1021/cb1002366  1
2010 Treweek JB, Roberts AJ, Janda KD. Superadditive effects of ethanol and flunitrazepam: implications of using immunopharmacotherapy as a therapeutic. Molecular Pharmaceutics. 7: 2056-68. PMID 20849117 DOI: 10.1021/mp900293a  1
2010 Garner AL, Janda KD. cat-ELCCA: a robust method to monitor the fatty acid acyltransferase activity of ghrelin O-acyltransferase (GOAT). Angewandte Chemie (International Ed. in English). 49: 9630-4. PMID 20845345 DOI: 10.1002/anie.201003387  1
2010 Lowery CA, Salzameda NT, Sawada D, Kaufmann GF, Janda KD. Medicinal chemistry as a conduit for the modulation of quorum sensing. Journal of Medicinal Chemistry. 53: 7467-89. PMID 20669927 DOI: 10.1021/jm901742e  1
2010 Staflin K, Krueger JS, Hachmann J, Forsyth JS, Lorger M, Steiniger SC, Mee J, Pop C, Salvesen GS, Janda KD, Felding-Habermann B. Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis. Clinical & Experimental Metastasis. 27: 217-31. PMID 20225083 DOI: 10.1007/s10585-010-9320-5  1
2010 Thyagarajan B, Potian JG, Garcia CC, Hognason K, Capková K, Moe ST, Jacobson AR, Janda KD, McArdle JJ. Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions. Neuropharmacology. 58: 1189-98. PMID 20211192 DOI: 10.1016/j.neuropharm.2010.02.014  1
2010 Silhár P, Capková K, Salzameda NT, Barbieri JT, Hixon MS, Janda KD. Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors. Journal of the American Chemical Society. 132: 2868-9. PMID 20158239 DOI: 10.1021/ja910761y  1
2010 Gloeckner C, Garner AL, Mersha F, Oksov Y, Tricoche N, Eubanks LM, Lustigman S, Kaufmann GF, Janda KD. Repositioning of an existing drug for the neglected tropical disease Onchocerciasis. Proceedings of the National Academy of Sciences of the United States of America. 107: 3424-9. PMID 20142509 DOI: 10.1073/pnas.0915125107  1
2010 Moreno AY, Azar MR, Warren NA, Dickerson TJ, Koob GF, Janda KD. A critical evaluation of a nicotine vaccine within a self-administration behavioral model. Molecular Pharmaceutics. 7: 431-41. PMID 20104903 DOI: 10.1021/mp900213u  1
2010 Stowe GN, Silhár P, Hixon MS, Silvaggi NR, Allen KN, Moe ST, Jacobson AR, Barbieri JT, Janda KD. Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease. Organic Letters. 12: 756-9. PMID 20092262 DOI: 10.1021/ol902820z  1
2010 Nakai Y, Pellett S, Tepp WH, Johnson EA, Janda KD. Toosendanin: synthesis of the AB-ring and investigations of its anti-botulinum properties (Part II). Bioorganic & Medicinal Chemistry. 18: 1280-7. PMID 20044261 DOI: 10.1016/j.bmc.2009.12.030  1
2010 Fukuchi K, Steiniger SC, Deryugina E, Liu Y, Lowery CA, Gloeckner C, Zhou B, Kaufmann GF, Quigley JP, Janda KD. Inhibition of tumor metastasis: functional immune modulation of the CUB domain containing protein 1. Molecular Pharmaceutics. 7: 245-53. PMID 19916495 DOI: 10.1021/mp900236t  1
2010 Capková K, Hixon MS, Pellett S, Barbieri JT, Johnson EA, Janda KD. Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase. Bioorganic & Medicinal Chemistry Letters. 20: 206-8. PMID 19914829 DOI: 10.1016/j.bmcl.2009.10.129  1
2009 Lowery CA, Abe T, Park J, Eubanks LM, Sawada D, Kaufmann GF, Janda KD. Revisiting AI-2 quorum sensing inhibitors: direct comparison of alkyl-DPD analogues and a natural product fimbrolide. Journal of the American Chemical Society. 131: 15584-5. PMID 19824634 DOI: 10.1021/ja9066783  1
2009 Lowery CA, Park J, Gloeckner C, Meijler MM, Mueller RS, Boshoff HI, Ulrich RL, Barry CE, Bartlett DH, Kravchenko VV, Kaufmann GF, Janda KD. Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals. Journal of the American Chemical Society. 131: 14473-9. PMID 19807189 DOI: 10.1021/ja9056079  1
2009 Salzameda NT, Barbieri JT, Janda KD. Synthetic substrate for application in both high and low throughput assays for botulinum neurotoxin B protease inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 5848-50. PMID 19747823 DOI: 10.1016/j.bmcl.2009.08.079  1
2009 Frederick MO, De Lamo Marin S, Janda KD, Nicolaou KC, Dickerson TJ. Monoclonal antibodies with orthogonal azaspiracid epitopes. Chembiochem : a European Journal of Chemical Biology. 10: 1625-9. PMID 19492388 DOI: 10.1002/cbic.200900201  1
2009 Moreno AY, Janda KD. Immunopharmacotherapy: vaccination strategies as a treatment for drug abuse and dependence. Pharmacology, Biochemistry, and Behavior. 92: 199-205. PMID 19350728 DOI: 10.1016/j.pbb.2009.01.015  1
2009 Capková K, Salzameda NT, Janda KD. Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins. Toxicon : Official Journal of the International Society On Toxinology. 54: 575-82. PMID 19327377 DOI: 10.1016/j.toxicon.2009.03.016  1
2009 Treweek JB, Dickerson TJ, Janda KD. Drugs of abuse that mediate advanced glycation end product formation: a chemical link to disease pathology. Accounts of Chemical Research. 42: 659-69. PMID 19275211 DOI: 10.1021/ar800247d  1
2009 Pires-Alves M, Ho M, Aberle KK, Janda KD, Wilson BA. Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity. Toxicon : Official Journal of the International Society On Toxinology. 53: 392-9. PMID 19168088 DOI: 10.1016/j.toxicon.2008.12.016  1
2009 Fischer A, Nakai Y, Eubanks LM, Clancy CM, Tepp WH, Pellett S, Dickerson TJ, Johnson EA, Janda KD, Montal M. Bimodal modulation of the botulinum neurotoxin protein-conducting channel. Proceedings of the National Academy of Sciences of the United States of America. 106: 1330-5. PMID 19164566 DOI: 10.1073/pnas.0812839106  1
2009 Nakai Y, Tepp WH, Dickerson TJ, Johnson EA, Janda KD. Function-oriented synthesis applied to the anti-botulinum natural product toosendanin. Bioorganic & Medicinal Chemistry. 17: 1152-7. PMID 19131252 DOI: 10.1016/j.bmc.2008.12.042  1
2009 Zhou H, Zhou B, Pellett S, Johnson EA, Janda KD. Selection and characterization of a human monoclonal neutralizing antibody for Clostridium Botulinum neurotoxin serotype B. Bioorganic & Medicinal Chemistry Letters. 19: 662-4. PMID 19112017 DOI: 10.1016/j.bmcl.2008.12.055  1
2009 Treweek JB, Moreno AY, Janda KD. SLEEPLESS-ness and insomnia in fruit flies. Angewandte Chemie (International Ed. in English). 48: 438-40. PMID 19072956 DOI: 10.1002/anie.200804552  1
2008 Mayorov AV, Amara N, Chang JY, Moss JA, Hixon MS, Ruiz DI, Meijler MM, Zorrilla EP, Janda KD. Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 17487-92. PMID 18981425 DOI: 10.1073/pnas.0711808105  1
2008 Treweek JB, Sun C, Mayorov AV, Qi L, Levy CL, Roberts AJ, Dickerson TJ, Janda KD. Prevention of drug-induced memory impairment by immunopharmacotherapy. Journal of Medicinal Chemistry. 51: 6866-75. PMID 18921991 DOI: 10.1021/jm800506v  1
2008 Willis B, Eubanks LM, Dickerson TJ, Janda KD. The strange case of the botulinum neurotoxin: using chemistry and biology to modulate the most deadly poison. Angewandte Chemie (International Ed. in English). 47: 8360-79. PMID 18844202 DOI: 10.1002/anie.200705531  1
2008 Steiniger SC, Coppinger JA, Krüger JA, Yates J, Janda KD. Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population. Stem Cells (Dayton, Ohio). 26: 3037-46. PMID 18802034 DOI: 10.1634/stemcells.2008-0397  1
2008 Park J, Kaufmann GF, Bowen JP, Arbiser JL, Janda KD. Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aeruginosa. The Journal of Infectious Diseases. 198: 1198-201. PMID 18713055 DOI: 10.1086/591916  1
2008 Capková K, Hixon MS, McAllister LA, Janda KD. Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations. Chemical Communications (Cambridge, England). 3525-7. PMID 18654701 DOI: 10.1039/b808305c  1
2008 Park J, Dickerson TJ, Janda KD. Major sperm protein as a diagnostic antigen for onchocerciasis. Bioorganic & Medicinal Chemistry. 16: 7206-9. PMID 18632276 DOI: 10.1016/j.bmc.2008.06.038  1
2008 Lowery CA, Park J, Kaufmann GF, Janda KD. An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues. Journal of the American Chemical Society. 130: 9200-1. PMID 18576653 DOI: 10.1021/ja802353j  1
2008 Lowery CA, Dickerson TJ, Janda KD. Interspecies and interkingdom communication mediated by bacterial quorum sensing. Chemical Society Reviews. 37: 1337-46. PMID 18568160 DOI: 10.1039/b702781h  1
2008 Kravchenko VV, Kaufmann GF, Mathison JC, Scott DA, Katz AZ, Grauer DC, Lehmann M, Meijler MM, Janda KD, Ulevitch RJ. Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. Science (New York, N.Y.). 321: 259-63. PMID 18566250 DOI: 10.1126/science.1156499  1
2008 Kaufmann GF, Park J, Janda KD. Bacterial quorum sensing: a new target for anti-infective immunotherapy. Expert Opinion On Biological Therapy. 8: 719-24. PMID 18476783 DOI: 10.1517/14712598.8.6.719  1
2008 Zhou B, Pellett S, Tepp WH, Zhou H, Johnson EA, Janda KD. Delineating the susceptibility of botulinum neurotoxins to denaturation through thermal effects. Febs Letters. 582: 1526-31. PMID 18396167 DOI: 10.1016/j.febslet.2008.03.047  1
2008 Debler EW, Kaufmann GF, Meijler MM, Heine A, Mee JM, Pljevaljcic G, Di Bilio AJ, Schultz PG, Millar DP, Janda KD, Wilson IA, Gray HB, Lerner RA. Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. Science (New York, N.Y.). 319: 1232-5. PMID 18309081 DOI: 10.1126/science.1153445  1
2008 Kaufmann GF, Park J, Mee JM, Ulevitch RJ, Janda KD. The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone. Molecular Immunology. 45: 2710-4. PMID 18304641 DOI: 10.1016/j.molimm.2008.01.010  1
2008 Zarebski LM, Vaughan K, Sidney J, Peters B, Grey H, Janda KD, Casadevall A, Sette A. Analysis of epitope information related to Bacillus anthracis and Clostridium botulinum. Expert Review of Vaccines. 7: 55-74. PMID 18251694 DOI: 10.1586/14760584.7.1.55  1
2008 Yoneda Y, Steiniger SC, Capková K, Mee JM, Liu Y, Kaufmann GF, Janda KD. A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy. Bioorganic & Medicinal Chemistry Letters. 18: 1632-6. PMID 18243696 DOI: 10.1016/j.bmcl.2008.01.060  1
2008 Willis B, Eubanks LM, Wood MR, Janda KD, Dickerson TJ, Lerner RA. Biologically templated organic polymers with nanoscale order. Proceedings of the National Academy of Sciences of the United States of America. 105: 1416-9. PMID 18216240 DOI: 10.1073/pnas.0711308105  1
2008 Richardson HN, Zhao Y, Fekete EM, Funk CK, Wirsching P, Janda KD, Zorrilla EP, Koob GF. MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist. Pharmacology, Biochemistry, and Behavior. 88: 497-510. PMID 18031798 DOI: 10.1016/j.pbb.2007.10.008  1
2008 Zhou B, Carney C, Janda KD. Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin. Bioorganic & Medicinal Chemistry. 16: 1903-13. PMID 18023190 DOI: 10.1016/j.bmc.2007.11.001  1
2007 Brogan AP, Dickerson TJ, Janda KD. Nornicotine-organocatalyzed aqueous reduction of alpha,beta-unsaturated aldehydes. Chemical Communications (Cambridge, England). 4952-4. PMID 18361380 DOI: 10.1039/b713273e  1
2007 Park J, Jagasia R, Kaufmann GF, Mathison JC, Ruiz DI, Moss JA, Meijler MM, Ulevitch RJ, Janda KD. Infection control by antibody disruption of bacterial quorum sensing signaling. Chemistry & Biology. 14: 1119-27. PMID 17961824 DOI: 10.1016/j.chembiol.2007.08.013  1
2007 Capková K, Yoneda Y, Dickerson TJ, Janda KD. Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 6463-6. PMID 17951059 DOI: 10.1016/j.bmcl.2007.09.103  1
2007 Zhou H, Zhou B, Ma H, Carney C, Janda KD. Selection and characterization of human monoclonal antibodies against Abrin by phage display. Bioorganic & Medicinal Chemistry Letters. 17: 5690-2. PMID 17764932 DOI: 10.1016/j.bmcl.2007.07.053  1
2007 Xu Y, Hixon MS, Dawson PE, Janda KD. Development of a FRET assay for monitoring of HIV gp41 core disruption. The Journal of Organic Chemistry. 72: 6700-7. PMID 17685571 DOI: 10.1021/jo070836l  1
2007 Dickerson TJ, McKenzie KM, Hoyt AS, Wood MR, Janda KD, Brenner SB, Lerner RA. Phage escape libraries for checkmate analysis. Proceedings of the National Academy of Sciences of the United States of America. 104: 12703-8. PMID 17646645 DOI: 10.1073/pnas.0705362104  1
2007 Treweek J, Wee S, Koob GF, Dickerson TJ, Janda KD. Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 11580-4. PMID 17592122 DOI: 10.1073/pnas.0701328104  1
2007 Ino A, Dickerson TJ, Janda KD. Positional linker effects in haptens for cocaine immunopharmacotherapy. Bioorganic & Medicinal Chemistry Letters. 17: 4280-3. PMID 17531484 DOI: 10.1016/j.bmcl.2007.05.032  1
2007 Silvaggi NR, Boldt GE, Hixon MS, Kennedy JP, Tzipori S, Janda KD, Allen KN. Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility. Chemistry & Biology. 14: 533-42. PMID 17524984 DOI: 10.1016/j.chembiol.2007.03.014  1
2007 Debler EW, Kaufmann GF, Kirchdoerfer RN, Mee JM, Janda KD, Wilson IA. Crystal structures of a quorum-quenching antibody. Journal of Molecular Biology. 368: 1392-402. PMID 17400249 DOI: 10.1016/j.jmb.2007.02.081  1
2007 Liu Y, Steiniger SC, Kim Y, Kaufmann GF, Felding-Habermann B, Janda KD. Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery. Molecular Pharmaceutics. 4: 435-47. PMID 17373820 DOI: 10.1021/mp060122j  1
2007 Xu Y, Hixon MS, Yamamoto N, McAllister LA, Wentworth AD, Wentworth P, Janda KD. Antibody-catalyzed anaerobic destruction of methamphetamine. Proceedings of the National Academy of Sciences of the United States of America. 104: 3681-6. PMID 17360412 DOI: 10.1073/pnas.0611094104  1
2007 Brogan AP, Eubanks LM, Koob GF, Dickerson TJ, Janda KD. Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol. Journal of the American Chemical Society. 129: 3698-702. PMID 17335216 DOI: 10.1021/ja070022m  1
2007 Eubanks LM, Dickerson TJ, Janda KD. Technological advancements for the detection of and protection against biological and chemical warfare agents. Chemical Society Reviews. 36: 458-70. PMID 17325785 DOI: 10.1039/b615227a  1
2007 McAllister LA, Hixon MS, Schwartz R, Kubitz DS, Janda KD. Synthesis and application of a novel ligand for affinity chromatography based removal of endotoxin from antibodies. Bioconjugate Chemistry. 18: 559-66. PMID 17315943 DOI: 10.1021/bc0602984  1
2007 Eubanks LM, Hixon MS, Jin W, Hong S, Clancy CM, Tepp WH, Baldwin MR, Malizio CJ, Goodnough MC, Barbieri JT, Johnson EA, Boger DL, Dickerson TJ, Janda KD. An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. Proceedings of the National Academy of Sciences of the United States of America. 104: 2602-7. PMID 17293454 DOI: 10.1073/pnas.0611213104  1
2007 De Lamo Marin S, Xu Y, Meijler MM, Janda KD. Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria. Bioorganic & Medicinal Chemistry Letters. 17: 1549-52. PMID 17254784 DOI: 10.1016/j.bmcl.2006.12.118  1
2007 Steiniger SC, Altobell LJ, Zhou B, Janda KD. Selection of human antibodies against cell surface-associated oligomeric anthrax protective antigen. Molecular Immunology. 44: 2749-55. PMID 17210180 DOI: 10.1016/j.molimm.2006.11.011  1
2007 McKenzie KM, Mee JM, Rogers CJ, Hixon MS, Kaufmann GF, Janda KD. Identification and characterization of single chain anti-cocaine catalytic antibodies. Journal of Molecular Biology. 365: 722-31. PMID 17084858 DOI: 10.1016/j.jmb.2006.10.031  1
2006 Dickerson TJ, Janda KD. The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication. Acs Chemical Biology. 1: 359-69. PMID 17163773 DOI: 10.1021/cb600179d  1
2006 Eubanks LM, Rogers CJ, Beuscher AE, Koob GF, Olson AJ, Dickerson TJ, Janda KD. A molecular link between the active component of marijuana and Alzheimer's disease pathology. Molecular Pharmaceutics. 3: 773-7. PMID 17140265 DOI: 10.1021/mp060066m  1
2006 Rogers CJ, Eubanks LM, Dickerson TJ, Janda KD. Unexpected acetylcholinesterase activity of cocaine esterases. Journal of the American Chemical Society. 128: 15364-5. PMID 17131989 DOI: 10.1021/ja066241+  1
2006 Brogan AP, Dickerson TJ, Janda KD. Enamine-based aldol organocatalysis in water: are they really "all wet"? Angewandte Chemie (International Ed. in English). 45: 8100-2. PMID 17001595 DOI: 10.1002/anie.200601392  1
2006 Kravchenko VV, Kaufmann GF, Mathison JC, Scott DA, Katz AZ, Wood MR, Brogan AP, Lehmann M, Mee JM, Iwata K, Pan Q, Fearns C, Knaus UG, Meijler MM, Janda KD, et al. N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways. The Journal of Biological Chemistry. 281: 28822-30. PMID 16893899 DOI: 10.1074/jbc.M606613200  1
2006 Zorrilla EP, Iwasaki S, Moss JA, Chang J, Otsuji J, Inoue K, Meijler MM, Janda KD. Vaccination against weight gain. Proceedings of the National Academy of Sciences of the United States of America. 103: 13226-31. PMID 16891413 DOI: 10.1073/pnas.0605376103  1
2006 Kim Y, Lillo AM, Steiniger SC, Liu Y, Ballatore C, Anichini A, Mortarini R, Kaufmann GF, Zhou B, Felding-Habermann B, Janda KD. Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand. Biochemistry. 45: 9434-44. PMID 16878978 DOI: 10.1021/bi060264j  1
2006 Boldt GE, Eubanks LM, Janda KD. Identification of a botulinum neurotoxin A protease inhibitor displaying efficacy in a cellular model. Chemical Communications (Cambridge, England). 3063-5. PMID 16855686 DOI: 10.1039/b603099h  1
2006 Fu Z, Chen S, Baldwin MR, Boldt GE, Crawford A, Janda KD, Barbieri JT, Kim JJ. Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate. Biochemistry. 45: 8903-11. PMID 16846233 DOI: 10.1021/bi060786z  1
2006 Xu Y, Lu H, Kennedy JP, Yan X, McAllister LA, Yamamoto N, Moss JA, Boldt GE, Jiang S, Janda KD. Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation. Journal of Combinatorial Chemistry. 8: 531-9. PMID 16827565 DOI: 10.1021/cc0600167  1
2006 Boldt GE, Kennedy JP, Hixon MS, McAllister LA, Barbieri JT, Tzipori S, Janda KD. Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors. Journal of Combinatorial Chemistry. 8: 513-21. PMID 16827563 DOI: 10.1021/cc060010h  1
2006 Ma H, Zhou B, Kim Y, Janda KD. A cyclic peptide-polymer probe for the detection of Clostridium botulinum neurotoxin serotype A. Toxicon : Official Journal of the International Society On Toxinology. 47: 901-8. PMID 16730044 DOI: 10.1016/j.toxicon.2006.03.003  1
2006 Moss JA, Stokols S, Hixon MS, Ashley FT, Chang JY, Janda KD. Solid-phase synthesis and kinetic characterization of fluorogenic enzyme-degradable hydrogel cross-linkers. Biomacromolecules. 7: 1011-6. PMID 16602715 DOI: 10.1021/bm051001s  1
2006 Boldt GE, Kennedy JP, Janda KD. Identification of a potent botulinum neurotoxin a protease inhibitor using in situ lead identification chemistry. Organic Letters. 8: 1729-32. PMID 16597152 DOI: 10.1021/ol0603211  1
2006 McAllister LA, Hixon MS, Kennedy JP, Dickerson TJ, Janda KD. Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: a new wrinkle in botulinum neurotoxin. Journal of the American Chemical Society. 128: 4176-7. PMID 16568962 DOI: 10.1021/ja057699z  1
2006 Boldt GE, Dickerson TJ, Janda KD. Emerging chemical and biological approaches for the preparation of discovery libraries. Drug Discovery Today. 11: 143-8. PMID 16533712 DOI: 10.1016/S1359-6446(05)03697-4  1
2006 Kaufmann GF, Sartorio R, Lee SH, Mee JM, Altobell LJ, Kujawa DP, Jeffries E, Clapham B, Meijler MM, Janda KD. Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing. Journal of the American Chemical Society. 128: 2802-3. PMID 16506750 DOI: 10.1021/ja0578698  1
2006 Zhu X, Dickerson TJ, Rogers CJ, Kaufmann GF, Mee JM, McKenzie KM, Janda KD, Wilson IA. Complete reaction cycle of a cocaine catalytic antibody at atomic resolution. Structure (London, England : 1993). 14: 205-16. PMID 16472740 DOI: 10.1016/j.str.2005.10.014  1
2006 Wu W, Luo Y, Sun C, Liu Y, Kuo P, Varga J, Xiang R, Reisfeld R, Janda KD, Edgington TS, Liu C. Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms. Cancer Research. 66: 970-80. PMID 16424032 DOI: 10.1158/0008-5472.CAN-05-2591  1
2006 Zhang L, Long H, Boldt GE, Janda KD, Schatz GC, Lewis FD. Alpha- and beta-stilbenosides as base-pair surrogates in DNA hairpins. Organic & Biomolecular Chemistry. 4: 314-22. PMID 16391774 DOI: 10.1039/b513694f  1
2006 Xu Y, Shi J, Yamamoto N, Moss JA, Vogt PK, Janda KD. A credit-card library approach for disrupting protein-protein interactions. Bioorganic & Medicinal Chemistry. 14: 2660-73. PMID 16384710 DOI: 10.1016/j.bmc.2005.11.052  1
2006 Shigenaga A, Moss JA, Ashley FT, Kaufmann GF, Janda KD. Solid-phase synthesis and cyclative cleavage of quorum sensing depsipeptide analogues by acylphenyldiazene activation Synlett. 551-554. DOI: 10.1055/s-2006-932468  1
2006 Rogers CJ, Dickerson TJ, Janda KD. Kinetic isotope and thermodynamic analysis of the nornicotine-catalyzed aqueous aldol reaction Tetrahedron. 62: 352-356. DOI: 10.1016/j.tet.2005.09.094  1
2006 Lillo AM, McKenzie KM, Janda KD. Phage-Displayed Antibody Libraries Cell Biology, Four-Volume Set. 1: 491-496. DOI: 10.1016/B978-012164730-8/50060-5  1
2005 Matsushita H, Yamamoto N, Meijler MM, Wirsching P, Lerner RA, Matsushita M, Janda KD. Chiral sensing using a blue fluorescent antibody. Molecular Biosystems. 1: 303-6. PMID 16880995 DOI: 10.1039/b511408j  1
2005 Dickerson TJ, Janda KD. Recent advances for the treatment of cocaine abuse: central nervous system immunopharmacotherapy. The Aaps Journal. 7: E579-86. PMID 16353936 DOI: 10.1208/aapsj070359  1
2005 Kim Y, Lillo A, Moss JA, Janda KD. A contiguous stretch of methionine residues mediates the energy-dependent internalization mechanism of a cell-penetrating peptide. Molecular Pharmaceutics. 2: 528-35. PMID 16323960 DOI: 10.1021/mp050035b  1
2005 Shute TS, Matsushita M, Dickerson TJ, La Clair JJ, Janda KD, Burkart MD. A site-specific bifunctional protein labeling system for affinity and fluorescent analysis. Bioconjugate Chemistry. 16: 1352-5. PMID 16287229 DOI: 10.1021/bc050213j  1
2005 Qi L, Yamamoto N, Meijler MM, Altobell LJ, Koob GF, Wirsching P, Janda KD. Delta9-tetrahydrocannabinol immunochemical studies: haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta9-tetrahydrocannabinol. Journal of Medicinal Chemistry. 48: 7389-99. PMID 16279798 DOI: 10.1021/jm050442r  1
2005 Toker JD, Tremblay MR, Yli-Kauhaluoma J, Wentworth AD, Zhou B, Wentworth P, Janda KD. Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction. The Journal of Organic Chemistry. 70: 7810-5. PMID 16277300 DOI: 10.1021/jo050410b  1
2005 Dickerson TJ, Beuscher AE, Rogers CJ, Hixon MS, Yamamoto N, Xu Y, Olson AJ, Janda KD. Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library. Biochemistry. 44: 14845-53. PMID 16274232 DOI: 10.1021/bi051613x  1
2005 Matsushita M, Meijler MM, Wirsching P, Lerner RA, Janda KD. A blue fluorescent antibody-cofactor sensor for mercury. Organic Letters. 7: 4943-6. PMID 16235928 DOI: 10.1021/ol051919w  1
2005 Eubanks LM, Dickerson TJ, Janda KD. Vitamin B2-mediated cellular photoinhibition of botulinum neurotoxin A. Febs Letters. 579: 5361-4. PMID 16198354 DOI: 10.1016/j.febslet.2005.08.072  1
2005 McKenzie KM, Meijler MM, Lowery CA, Boldt GE, Janda KD. A furanosyl-carbonate autoinducer in cell-to-cell communication of V. harveyi. Chemical Communications (Cambridge, England). 4863-5. PMID 16193140 DOI: 10.1039/b509396a  1
2005 Xu Y, Yamamoto N, Ruiz DI, Kubitz DS, Janda KD. Squaric monoamide monoester as a new class of reactive immunization hapten for catalytic antibodies Bioorganic and Medicinal Chemistry Letters. 15: 4304-4307. PMID 16046128 DOI: 10.1016/j.bmcl.2005.06.052  1
2005 Carrera MR, Trigo JM, Wirsching P, Roberts AJ, Janda KD. Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose. Pharmacology, Biochemistry, and Behavior. 81: 709-14. PMID 16005948 DOI: 10.1016/j.pbb.2005.04.018  1
2005 Meijler MM, Kaufmann GF, Qi L, Mee JM, Coyle AR, Moss JA, Wirsching P, Matsushita M, Janda KD. Fluorescent cocaine probes: a tool for the selection and engineering of therapeutic antibodies. Journal of the American Chemical Society. 127: 2477-84. PMID 15725002 DOI: 10.1021/ja043935e  0.68
2005 Moss JA, Lillo A, Kim YS, Gao C, Ditzel H, Janda KD. A dimerization "switch" in the internalization mechanism of a cell-penetrating peptide. Journal of the American Chemical Society. 127: 538-9. PMID 15643874 DOI: 10.1021/ja0443171  0.64
2005 Kaufmann GF, Sartorio R, Lee SH, Rogers CJ, Meijler MM, Moss JA, Clapham B, Brogan AP, Dickerson TJ, Janda KD. Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. Proceedings of the National Academy of Sciences of the United States of America. 102: 309-14. PMID 15623555 DOI: 10.1073/pnas.0408639102  1
2005 Yamashita M, Lee SH, Koch G, Zimmermann J, Clapham B, Janda KD. Solid-phase synthesis of oxazolones and other heterocycles via Wang resin-bound diazocarbonyls Tetrahedron Letters. 46: 5495-5498. DOI: 10.1016/j.tetlet.2005.06.061  1
2005 Shimomura O, Se Lee B, Meth S, Suzuki H, Mahajan S, Nomura R, Janda KD. Synthesis and application of polytetrahydrofuran-grafted polystyrene (PS-PTHF) resin supports for organic synthesis Tetrahedron. 61: 12160-12167. DOI: 10.1016/j.tet.2005.08.121  1
2005 Rogers CJ, Dickerson TJ, Wentworth P, Janda KD. A high-swelling reagent scaffold suitable for use in aqueous and organic solvents Tetrahedron. 61: 12140-12144. DOI: 10.1016/j.tet.2005.07.115  1
2004 Meijler MM, Matsushita M, Wirsching P, Janda KD. Development of immunopharmacotherapy against drugs of abuse. Current Drug Discovery Technologies. 1: 77-89. PMID 16472221  0.68
2004 Felding-Habermann B, Lerner RA, Lillo A, Zhuang S, Weber MR, Arrues S, Gao C, Mao S, Saven A, Janda KD. Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis. Proceedings of the National Academy of Sciences of the United States of America. 101: 17210-5. PMID 15563590 DOI: 10.1073/pnas.0407869101  1
2004 Kim YS, Moss JA, Janda KD. Biological tuning of synthetic tactics in solid-phase synthesis: application to A beta(1-42). The Journal of Organic Chemistry. 69: 7776-8. PMID 15498016 DOI: 10.1021/jo048922y  0.64
2004 Carrera MR, Meijler MM, Janda KD. Cocaine pharmacology and current pharmacotherapies for its abuse. Bioorganic & Medicinal Chemistry. 12: 5019-30. PMID 15351386 DOI: 10.1016/j.bmc.2004.06.018  0.68
2004 Lillo AM, Sun C, Gao C, Ditzel H, Parrish J, Gauss CM, Moss J, Felding-Habermann B, Wirsching P, Boger DL, Janda KD. A human single-chain antibody specific for integrin alpha3beta1 capable of cell internalization and delivery of antitumor agents. Chemistry & Biology. 11: 897-906. PMID 15271348 DOI: 10.1016/j.chembiol.2004.04.018  1
2004 Carrera MR, Kaufmann GF, Mee JM, Meijler MM, Koob GF, Janda KD. Treating cocaine addiction with viruses. Proceedings of the National Academy of Sciences of the United States of America. 101: 10416-21. PMID 15226496 DOI: 10.1073/pnas.0403795101  0.88
2004 Meijler MM, Hom LG, Kaufmann GF, McKenzie KM, Sun C, Moss JA, Matsushita M, Janda KD. Synthesis and biological validation of a ubiquitous quorum-sensing molecule. Angewandte Chemie (International Ed. in English). 43: 2106-8. PMID 15083457 DOI: 10.1002/anie.200353150  1
2004 Ahn JM, Wentworth P, Janda KD. Probing lipase/esterase libraries for lipid A hydrolases--discovery of biocatalysts for the detoxification of bacterially-expressed recombinant protein. Chemical Communications (Cambridge, England). 364-5. PMID 14765210 DOI: 10.1039/b312662e  0.64
2004 Carrera MR, Ashley JA, Hoffman TZ, Isomura S, Wirsching P, Koob GF, Janda KD. Investigations using immunization to attenuate the psychoactive effects of nicotine. Bioorganic & Medicinal Chemistry. 12: 563-70. PMID 14738965  0.88
2003 Moss JA, Coyle AR, Ahn JM, Meijler MM, Offer J, Janda KD. Tandem IMAC-HPLC purification of a cocaine-binding scFv antibody. Journal of Immunological Methods. 281: 143-8. PMID 14580888  0.68
2003 Ahn JM, Wentworth P, Janda KD. Soluble polymer-supported convergent parallel library synthesis. Chemical Communications (Cambridge, England). 480-1. PMID 12638959  0.64
2003 Gao C, Mao S, Ronca F, Zhuang S, Quaranta V, Wirsching P, Janda KD. De novo identification of tumor-specific internalizing human antibody-receptor pairs by phage-display methods. Journal of Immunological Methods. 274: 185-97. PMID 12609544 DOI: 10.1016/S0022-1759(02)00522-7  1
2002 Gao C, Mao S, Ditzel HJ, Farnaes L, Wirsching P, Lerner RA, Janda KD. A cell-penetrating peptide from a novel pVII-pIX phage-displayed random peptide library. Bioorganic & Medicinal Chemistry. 10: 4057-65. PMID 12413859 DOI: 10.1016/S0968-0896(02)00340-1  1
2002 Lee KJ, Mao S, Sun C, Gao C, Blixt O, Arrues S, Hom LG, Kaufmann GF, Hoffman TZ, Coyle AR, Paulson J, Felding-Habermann B, Janda KD. Phage-display selection of a human single-chain fv antibody highly specific for melanoma and breast cancer cells using a chemoenzymatically synthesized G(M3)-carbohydrate antigen. Journal of the American Chemical Society. 124: 12439-46. PMID 12381184  0.64
2002 Ahn JM, Boyle NA, MacDonald MT, Janda KD. Peptidomimetics and peptide backbone modifications. Mini Reviews in Medicinal Chemistry. 2: 463-73. PMID 12370047  1
2002 Gao C, Mao S, Kaufmann G, Wirsching P, Lerner RA, Janda KD. A method for the generation of combinatorial antibody libraries using pIX phage display. Proceedings of the National Academy of Sciences of the United States of America. 99: 12612-6. PMID 12239343 DOI: 10.1073/pnas.192467999  1
2001 Kozlov IA, Mao S, Xu Y, Huang X, Lee L, Sears PS, Gao C, Coyle AR, Janda KD, Wong CH. Synthesis of solid-supported mirror-image sugars: a novel method for selecting receptors for cellular-surface carbohydrates. Chembiochem : a European Journal of Chemical Biology. 2: 741-6. PMID 11948856 DOI: 10.1002/1439-7633(20011001)2:10<741::AID-CBIC741>3.0.CO;2-B  1
2001 Carrera MR, Ashley JA, Wirsching P, Koob GF, Janda KD. A second-generation vaccine protects against the psychoactive effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America. 98: 1988-92. PMID 11172063 DOI: 10.1073/pnas.041610998  0.88
2000 Carrera MR, Ashley JA, Zhou B, Wirsching P, Koob GF, Janda KD. Cocaine vaccines: antibody protection against relapse in a rat model. Proceedings of the National Academy of Sciences of the United States of America. 97: 6202-6. PMID 10823960  0.88
1999 Paschall CM, Hasserodt J, Jones T, Lerner RA, Janda KD, Christianson DW. Convergence of Catalytic Antibody and Terpene Cyclase Mechanisms: Polyene Cyclization Directed by Carbocation-π Interactions. Angewandte Chemie (International Ed. in English). 38: 1743-1747. PMID 29711206 DOI: 10.1002/(SICI)1521-3773(19990614)38:12<1743::AID-ANIE1743>3.0.CO;2-3  0.48
1999 Ashley JA, Lin CH, Wirsching P, Janda KD. Monitoring Chemical Warfare Agents: A New Method for the Detection of Methylphosphonic Acid. Angewandte Chemie (International Ed. in English). 38: 1793-1795. PMID 29711182 DOI: 10.1002/(SICI)1521-3773(19990614)38:12<1793::AID-ANIE1793>3.0.CO;2-U  0.48
1999 Mao S, Gao C, Lo CH, Wirsching P, Wong CH, Janda KD. Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewisx and Lewisx. Proceedings of the National Academy of Sciences of the United States of America. 96: 6953-8. PMID 10359820  0.48
1999 Gao C, Mao S, Lo CH, Wirsching P, Lerner RA, Janda KD. Making artificial antibodies: a format for phage display of combinatorial heterodimeric arrays. Proceedings of the National Academy of Sciences of the United States of America. 96: 6025-30. PMID 10339535 DOI: 10.1073/pnas.96.11.6025  1
1998 Heine A, Stura EA, Yli-Kauhaluoma JT, Gao C, Deng Q, Beno BR, Houk KN, Janda KD, Wilson IA. An antibody exo Diels-Alderase inhibitor complex at 1.95 angstrom resolution. Science (New York, N.Y.). 279: 1934-40. PMID 9506943  0.64
1997 Gao C, Lin CH, Lo CH, Mao S, Wirsching P, Lerner RA, Janda KD. Making chemistry selectable by linking it to infectivity. Proceedings of the National Academy of Sciences of the United States of America. 94: 11777-82. PMID 9342313 DOI: 10.1073/pnas.94.22.11777  1
1995 Carrera MR, Ashley JA, Parsons LH, Wirsching P, Koob GF, Janda KD. Suppression of psychoactive effects of cocaine by active immunization. Nature. 378: 727-30. PMID 7501020 DOI: 10.1038/378727a0  1
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