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Victor J. Hruby, Ph.D. - Publications

Affiliations: 
University of Arizona, Tucson, AZ 
Area:
Organic Chemistry, Biochemistry, Chemical Biology and Medicinal Chemistry
Website:
https://cbc.arizona.edu/faculty/victor-hruby
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Year Citation  Score
2020 Zhou Y, Mowlazadeh Haghighi S, Liu Z, Wang L, Hruby VJ, Cai M. Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor. Acs Pharmacology & Translational Science. 3: 921-930. PMID 33073191 DOI: 10.1021/acsptsci.0c00072  1
2020 Kadiri JJ, Thapa K, Kaipio K, Cai M, Hruby VJ, Rinne P. Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice. European Journal of Pharmacology. 173186. PMID 32416182 DOI: 10.1016/j.ejphar.2020.173186  1
2019 Wu Z, Hruby VJ. Toward a Universal μ-Agonist Template for Template-Based Alignment Modeling of Opioid Ligands. Acs Omega. 4: 17457-17476. PMID 31656918 DOI: 10.1021/acsomega.9b02244  1
2019 Zhou Y, Banday AH, Hruby VJ, Cai M. Development of -Acetylated Dipalmitoyl--Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists. Molecules (Basel, Switzerland). 24. PMID 31569697 DOI: 10.3390/molecules24193512  1
2018 Zhou Y, Mowlazadeh Haghighi S, Zoi I, Sawyer JR, Hruby VJ, Cai M. Correction to Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation. Journal of Medicinal Chemistry. PMID 30252463 DOI: 10.1021/acs.jmedchem.8b01423  1
2018 Eerola K, Virtanen S, Vähätalo L, Ailanen L, Cai M, Hruby V, Savontaus M, Savontaus E. Hypothalamic γ-melanocyte stimulating hormone gene delivery reduces fat mass in male mice. The Journal of Endocrinology. PMID 30006340 DOI: 10.1530/JOE-18-0009  1
2018 Olson KM, Keresztes A, Tashiro JK, Daconta LV, Hruby VJ, Streicher JM. Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice. Journal of Medicinal Chemistry. PMID 29939746 DOI: 10.1021/acs.jmedchem.8b00403  0.88
2018 Remesic M, Macedonio G, Mollica A, Porreca F, Hruby V, Lee YS. Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors. Bioorganic & Medicinal Chemistry. PMID 29858157 DOI: 10.1016/j.bmc.2018.05.045  1
2018 Mowlazadeh Haghighi S, Zhou Y, Dai J, Sawyer JR, Hruby VJ, Cai M. Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH, leads to hMC1R selectivity and pigmentation. European Journal of Medicinal Chemistry. 151: 815-823. PMID 29679901 DOI: 10.1016/j.ejmech.2018.04.021  1
2018 Merlino F, Zhou Y, Cai M, Carotenuto A, Yousif AM, Brancaccio D, Di Maro S, Zappavigna S, Limatola A, Novellino E, Grieco P, Hruby VJ. Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors. Journal of Medicinal Chemistry. PMID 29660981 DOI: 10.1021/acs.jmedchem.8b00488  1
2018 Durek T, Cromm PM, White AM, Schroeder CI, Kaas Q, Weidmann J, Ahmad Fuaad A, Cheneval O, Harvey PJ, Daly NL, Zhou Y, Dellsén A, Österlund T, Larsson N, Knerr L, ... ... Hruby VJ, et al. Development of novel melanocortin receptor agonists based on the cyclic peptide framework of sunflower trypsin inhibitor-1. Journal of Medicinal Chemistry. PMID 29605997 DOI: 10.1021/acs.jmedchem.8b00170  1
2017 Zhou Y, Mowlazadeh Haghighi S, Zoi I, Sawyer JR, Hruby VJ, Cai M. Design of MC1R selective γ-MSH analogues with canonical amino acids leads to potency and pigmentation. Journal of Medicinal Chemistry. PMID 29094944 DOI: 10.1021/acs.jmedchem.7b01295  1
2017 Vardanyan RS, Cain JP, Haghighi SM, Kumirov VK, McIntosh MI, Sandweiss AJ, Porreca F, Hruby VJ. Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain. Journal of Heterocyclic Chemistry. 54: 1228-1235. PMID 28819330 DOI: 10.1002/jhet.2696  1
2017 Cai M, Marelli UK, Mertz B, Beck JG, Opperer F, Rechenmacher F, Kessler H, Hruby VJ. Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists. Biochemistry. PMID 28715181 DOI: 10.1021/acs.biochem.7b00407  1
2017 Stefanucci A, Lei W, Hruby VJ, Macedonio G, Luisi G, Carradori S, Streicher JM, Mollica A. Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers. Future Medicinal Chemistry. PMID 28635314 DOI: 10.4155/fmc-2016-0232  0.88
2017 Sandweiss AJ, McIntosh MI, Moutal A, Davidson-Knapp R, Hu J, Giri AK, Yamamoto T, Hruby VJ, Khanna R, Largent-Milnes TM, Vanderah TW. Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential. Molecular Psychiatry. PMID 28485408 DOI: 10.1038/mp.2017.102  1
2017 Rinne P, Rami M, Nuutinen SL, Santovito D, van der Vorst EPC, Guillamat-Prats R, Lyytikäinen LP, Raitoharju E, Oksala N, Ring L, Cai M, Hruby VJ, Lehtimäki TJ, Weber C, Steffens S. Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages. Circulation. PMID 28450348 DOI: 10.1161/CIRCULATIONAHA.116.025889  1
2017 Remesic MV, Hruby VJ, Porreca F, Lee YS. Recent Advances in the Realm of Allosteric Modulators for the Opioid Receptors for Future Therapeutics. Acs Chemical Neuroscience. PMID 28368571 DOI: 10.1021/acschemneuro.7b00090  1
2016 Ramos-Colon CN, Lee YS, Remesic MV, Hall SM, LaVigne J, Davis P, Sandweiss AJ, McIntosh MI, Hanson J, Largent-Milnes TM, Vanderah TW, Streicher JM, Porreca F, Hruby VJ. Structure Activity Relationships of [des-Arg(7)]- Dynorphin A Analogues at the Kappa Opioid Receptor. Journal of Medicinal Chemistry. PMID 27797517 DOI: 10.1021/acs.jmedchem.6b01411  1
2016 Lee YS, Remesic M, Ramos-Colon C, Hall SM, Kuzmin A, Rankin D, Porreca F, Lai J, Hruby VJ. Cyclic non-opioid dynorphin A analogues for the bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. PMID 27756562 DOI: 10.1016/j.bmcl.2016.10.010  1
2016 Hall SM, LeBaron L, Ramos-Colon CN, Qu C, Xie JY, Porreca F, Lai J, Lee YS, Hruby VJ. Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain. Acs Chemical Neuroscience. PMID 27619237 DOI: 10.1021/acschemneuro.6b00258  1
2016 Cai M, Hruby VJ. Design of Cyclized Selective Melanotropins. Biopolymers. PMID 27561155 DOI: 10.1002/bip.22976  1
2016 Islam MR, Yang L, Lee YS, Hruby VJ, Karamyan VT, Abbruscato TJ. Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment. Current Pharmaceutical Design. PMID 27510489  1
2016 Lee YS, Kupp R, Remesic M, Ramos-Colon C, Hall SM, Chan C, Rankin D, Lai J, Porreca F, Hruby VJ. Various modifications of the amphipathic dynorphin A phamacophore for rat brain bradykinin receptors. Chemical Biology & Drug Design. PMID 27203574 DOI: 10.1111/cbdd.12789  1
2016 Remesic M, Lee YS, Hruby VJ. Cyclic Opioid Peptides. Current Medicinal Chemistry. PMID 27117332  1
2016 Cai M, Hruby VJ. The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases. Current Protein & Peptide Science. PMID 26916163  1
2016 Hall SM, Lee YS, Hruby VJ. Dynorphin A analogs for the treatment of chronic neuropathic pain. Future Medicinal Chemistry. PMID 26824470 DOI: 10.4155/fmc.15.164  1
2016 Vardanyan RS, Cain JP, Haghighi SM, Kumirov VK, Mcintosh MI, Sandweiss AJ, Porreca F, Hruby VJ. Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain Journal of Heterocyclic Chemistry. DOI: 10.1002/jhet.2696  1
2015 Huynh AS, Estrella V, Stark VE, Cohen AS, Chen T, Casagni TJ, Josan JS, Lloyd MC, Johnson J, Kim J, Hruby VJ, Vagner J, Morse DL. Tumor Targeting and Pharmacokinetics of a Near Infrared Fluorescent-labeled δ-Opioid Receptor Antagonist Agent, Dmt-Tic-Cy5. Molecular Pharmaceutics. PMID 26713599 DOI: 10.1021/acs.molpharmaceut.5b00760  1
2015 Deekonda S, Rankin D, Davis P, Lai J, Vanderah TW, Porecca F, Hruby VJ. Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands. Bioorganic & Medicinal Chemistry. PMID 26712115 DOI: 10.1016/j.bmc.2015.11.030  0.56
2015 Deekonda S, Cole J, Sunna S, Rankin D, Largent-Milnes TM, Davis P, BassiriRad NM, Lai J, Vanderah TW, Porecca F, Hruby VJ. Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations. Bioorganic & Medicinal Chemistry Letters. PMID 26611918 DOI: 10.1016/j.bmcl.2015.10.081  1
2015 Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P. Discovery of Novel Potent and Selective Agonists at the Melanocortin‑3 Receptor. Journal of Medicinal Chemistry. PMID 26599352 DOI: 10.1021/acs.jmedchem.5b01285  0.56
2015 Giri AK, Apostol CR, Wang Y, Forte BL, Largent-Milnes TM, Davis P, Rankin D, Molnar G, Olson KM, Porreca F, Vanderah TW, Hruby VJ. Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain. Journal of Medicinal Chemistry. PMID 26465170 DOI: 10.1021/acs.jmedchem.5b01170  1
2015 Shukla C, Koch LG, Britton SL, Cai M, Hruby VJ, Bednarek M, Novak CM. Contribution of regional brain melanocortin receptor subtypes to elevated activity energy expenditure in lean, active rats. Neuroscience. PMID 26404873 DOI: 10.1016/j.neuroscience.2015.09.035  1
2015 Deekonda S, Wugalter L, Rankin D, Largent-Milnes TM, Davis P, Wang Y, Bassirirad NM, Lai J, Kulkarni V, Vanderah TW, Porreca F, Hruby VJ. Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 26323872 DOI: 10.1016/j.bmcl.2015.07.064  1
2015 Deekonda S, Rankin D, Davis P, Lai J, Porreca F, Hruby VJ. Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors. Bioorganic & Medicinal Chemistry Letters. 25: 4148-52. PMID 26316468 DOI: 10.1016/j.bmcl.2015.08.014  1
2015 Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands. Bioorganic & Medicinal Chemistry. 23: 6185-94. PMID 26299827 DOI: 10.1016/j.bmc.2015.07.071  1
2015 Lee YS, Hall SM, Ramos-Colon C, Remesic M, Rankin D, Vanderah TW, Porreca F, Lai J, Hruby VJ. Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors. Receptors & Clinical Investigation. 2. PMID 26221618 DOI: 10.14800/rci.517  1
2015 Cai M, Marelli UK, Bao J, Beck JG, Opperer F, Rechenmacher F, McLeod KR, Zingsheim MR, Doedens L, Kessler H, Hruby VJ. Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors. Journal of Medicinal Chemistry. 58: 6359-67. PMID 26218460 DOI: 10.1021/acs.jmedchem.5b00102  1
2015 Nair P, Yamamoto T, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 25: 3716-20. PMID 26212775 DOI: 10.1016/j.bmcl.2015.06.030  1
2015 Mehr-un-Nisa, Munawar MA, Lee YS, Rankin D, Munir J, Lai J, Khan MA, Hruby VJ. Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs. Bioorganic & Medicinal Chemistry. 23: 1251-9. PMID 25703306 DOI: 10.1016/j.bmc.2015.01.047  1
2015 Van der Poorten O, Fehér K, Buysse K, Feytens D, Zoi I, Schwartz SD, Martins JC, Tourwé D, Cai M, Hruby VJ, Ballet S. Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist. Acs Medicinal Chemistry Letters. 6: 192-7. PMID 25699148 DOI: 10.1021/ml500436s  1
2015 Bird MF, Vardanyan RS, Hruby VJ, Calò G, Guerrini R, Salvadori S, Trapella C, McDonald J, Rowbotham DJ, Lambert DG. Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands. British Journal of Anaesthesia. 114: 646-56. PMID 25680364 DOI: 10.1093/bja/aeu454  1
2015 Lee YS, Hall SM, Ramos-Colon C, Remesic M, LeBaron L, Nguyen A, Rankin D, Porreca F, Lai J, Hruby VJ. Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 25: 30-3. PMID 25434001 DOI: 10.1016/j.bmcl.2014.11.026  1
2015 Banday AH, Jeelani S, Hruby VJ. Cancer vaccine adjuvants--recent clinical progress and future perspectives. Immunopharmacology and Immunotoxicology. 37: 1-11. PMID 25318595 DOI: 10.3109/08923973.2014.971963  1
2015 Banday AH, Kulkarni VV, Hruby VJ. Design, synthesis, and biological and docking studies of novel epipodophyllotoxin-chalcone hybrids as potential anticancer agents Medchemcomm. 6: 94-104. DOI: 10.1039/c4md00325j  1
2015 Cai M, Marelli UK, Bao J, Beck JG, Opperer F, Rechenmacher F, McLeod KR, Zingsheim MR, Doedens L, Kessler H, Hruby VJ. Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors Journal of Medicinal Chemistry. 58: 6359-6367. DOI: 10.1021/acs.jmedchem.5b00102  1
2015 Deekonda S, Rankin D, Davis P, Lai J, Porreca F, Hruby VJ. Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.08.014  1
2015 Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands Bioorganic and Medicinal Chemistry. 23: 6185-6194. DOI: 10.1016/j.bmc.2015.07.071  1
2015 Mollica A, Stefanucci A, Costante R, Hruby VJ. Rational approach to the design of bioactive peptidomimetics: Recent developments in opioid agonist peptides Studies in Natural Products Chemistry. 46: 27-68. DOI: 10.1016/B978-0-444-63462-7.00002-6  1
2014 Fernandes SM, Lee YS, Gillies RJ, Hruby VJ. Synthesis and evaluation of bivalent ligands for binding to the human melanocortin-4 receptor. Bioorganic & Medicinal Chemistry. 22: 6360-5. PMID 25438759 DOI: 10.1016/j.bmc.2014.09.055  1
2014 Lee YS, Rankin D, Hall SM, Ramos-Colon C, Ortiz JJ, Kupp R, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of non-opioid [des-Arg(7)]-dynorphin A analogues for bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 24: 4976-9. PMID 25282551 DOI: 10.1016/j.bmcl.2014.09.033  1
2014 Mollica A, Carotenuto A, Novellino E, Limatola A, Costante R, Pinnen F, Stefanucci A, Pieretti S, Borsodi A, Samavati R, Zador F, Benyhe S, Davis P, Porreca F, Hruby VJ. Novel cyclic biphalin analogue with improved antinociceptive properties. Acs Medicinal Chemistry Letters. 5: 1032-6. PMID 25221662 DOI: 10.1021/ml500241n  1
2014 Lee YS, Muthu D, Hall SM, Ramos-Colon C, Rankin D, Hu J, Sandweiss AJ, De Felice M, Xie JY, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord. Journal of the American Chemical Society. 136: 6608-16. PMID 24742335 DOI: 10.1021/ja501677q  1
2014 Vardanyan RS, Hruby VJ. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Medicinal Chemistry. 6: 385-412. PMID 24635521 DOI: 10.4155/fmc.13.215  1
2014 Giri AK, Hruby VJ. Investigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of pain. Expert Opinion On Investigational Drugs. 23: 227-41. PMID 24329035 DOI: 10.1517/13543784.2014.856879  1
2014 Banday AH, Hruby VJ. Regioselective N/C-heterocyclization of allenylindium bromide across aryl azides: One-pot synthesis of 5-methyl-1,2,3-triazoles Synlett. 25: 1859-1862. DOI: 10.1055/s-0034-1378327  1
2014 Karthikeyan B, Giri AK, Hruby VJ. Entrap and release of Phe–Phe nanotubes in sol–gel derived silicate matrix: study through nanosilver interaction Journal of Sol-Gel Science and Technology. 72: 534-542. DOI: 10.1007/s10971-014-3470-x  1
2013 Lee YS, Qu HC, Davis P, Ma SW, Vardanyan R, Lai J, Porreca F, Hruby VJ. Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities. Acs Medicinal Chemistry Letters. 4: 656-659. PMID 24648867 DOI: 10.1021/ml400115n  1
2013 Podolsky AT, Sandweiss A, Hu J, Bilsky EJ, Cain JP, Kumirov VK, Lee YS, Hruby VJ, Vardanyan RS, Vanderah TW. Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain. Life Sciences. 93: 1010-6. PMID 24084045 DOI: 10.1016/j.lfs.2013.09.016  1
2013 Nair P, Yamamoto T, Largent-Milnes TM, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 23: 4975-8. PMID 23899615 DOI: 10.1016/j.bmcl.2013.06.065  1
2013 Alleti R, Vagner J, Dehigaspitiya DC, Moberg VE, Elshan NG, Tafreshi NK, Brabez N, Weber CS, Lynch RM, Hruby VJ, Gillies RJ, Morse DL, Mash EA. Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors. Bioorganic & Medicinal Chemistry. 21: 5029-38. PMID 23890524 DOI: 10.1016/j.bmc.2013.06.052  1
2013 Barkey NM, Preihs C, Cornnell HH, Martinez G, Carie A, Vagner J, Xu L, Lloyd MC, Lynch VM, Hruby VJ, Sessler JL, Sill KN, Gillies RJ, Morse DL. Development and in vivo quantitative magnetic resonance imaging of polymer micelles targeted to the melanocortin 1 receptor. Journal of Medicinal Chemistry. 56: 6330-8. PMID 23863078 DOI: 10.1021/jm4005576  1
2013 Largent-Milnes TM, Brookshire SW, Skinner DP, Hanlon KE, Giuvelis D, Yamamoto T, Davis P, Campos CR, Nair P, Deekonda S, Bilsky EJ, Porreca F, Hruby VJ, Vanderah TW. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. The Journal of Pharmacology and Experimental Therapeutics. 347: 7-19. PMID 23860305 DOI: 10.1124/jpet.113.205245  1
2013 Petrov RR, Lee YS, Vardanyan RS, Liu L, Ma SW, Davis P, Lai J, Porreca F, Vanderah TW, Hruby VJ. Effect of anchoring 4-anilidopiperidines to opioid peptides. Bioorganic & Medicinal Chemistry Letters. 23: 3434-7. PMID 23623418 DOI: 10.1016/j.bmcl.2013.03.065  1
2013 Hruby VJ. Adventures in peptides and science with students! the joys of research. Biopolymers. 100: 127-31. PMID 23616095 DOI: 10.1002/bip.22179  1
2013 Mollica A, Pinnen F, Costante R, Locatelli M, Stefanucci A, Pieretti S, Davis P, Lai J, Rankin D, Porreca F, Hruby VJ. Biological active analogues of the opioid peptide biphalin: mixed α/β(3)-peptides. Journal of Medicinal Chemistry. 56: 3419-23. PMID 23547584 DOI: 10.1021/jm301456c  1
2013 Brabez N, Saunders K, Nguyen KL, Jayasundera TB, Weber C, Lynch RM, Chassaing G, Lavielle S, Hruby VJ. Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting. Acs Medicinal Chemistry Letters. 4: 98-102. PMID 23524643 DOI: 10.1021/ml300312b  1
2013 Brabez N, Nguyen KL, Saunders K, Lacy R, Xu L, Gillies RJ, Lynch RM, Chassaing G, Lavielle S, Hruby VJ. Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment. Bioorganic & Medicinal Chemistry Letters. 23: 2422-5. PMID 23489620 DOI: 10.1016/j.bmcl.2013.02.022  1
2013 Mehr-Un-Nisa, Munawar MA, Hall GB, Roberts SA, Hruby VJ. tert-Butyl 4-(3,4-dichloro-anilino)piperidine-1-carboxyl-ate. Acta Crystallographica. Section E, Structure Reports Online. 69: o205. PMID 23424488 DOI: 10.1107/S1600536812051896  1
2013 Hruby VJ, Cai M. Design of peptide and peptidomimetic ligands with novel pharmacological activity profiles. Annual Review of Pharmacology and Toxicology. 53: 557-80. PMID 23294313 DOI: 10.1146/annurev-pharmtox-010510-100456  1
2013 Cai M, Stankova M, Muthu D, Mayorov A, Yang Z, Trivedi D, Cabello C, Hruby VJ. An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells. Biochemistry. 52: 752-64. PMID 23276279 DOI: 10.1021/bi300723f  1
2013 Rinne P, Nordlund W, Heinonen I, Penttinen AM, Saraste A, Ruohonen ST, Mäkelä S, Vähätalo L, Kaipio K, Cai M, Hruby VJ, Ruohonen S, Savontaus E. α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction. Cardiovascular Research. 97: 360-8. PMID 23131503 DOI: 10.1093/cvr/cvs335  1
2012 Xu L, Josan JS, Vagner J, Caplan MR, Hruby VJ, Mash EA, Lynch RM, Morse DL, Gillies RJ. Heterobivalent ligands target cell-surface receptor combinations in vivo. Proceedings of the National Academy of Sciences of the United States of America. 109: 21295-300. PMID 23236171 DOI: 10.1073/pnas.1211762109  1
2012 Mollica A, Pinnen F, Stefanucci A, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2. Journal of Medicinal Chemistry. 55: 8477-82. PMID 22966938 DOI: 10.1021/jm300947s  1
2012 Tumati S, Largent-Milnes TM, Keresztes AI, Yamamoto T, Vanderah TW, Roeske WR, Hruby VJ, Varga EV. Tachykinin NK₁ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation. European Journal of Pharmacology. 684: 64-70. PMID 22724132 DOI: 10.1016/j.ejphar.2012.03.025  1
2012 Mollica A, Pinnen F, Stefanucci A, Feliciani F, Campestre C, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues. Journal of Medicinal Chemistry. 55: 3027-35. PMID 22394120 DOI: 10.1021/jm201402v  1
2012 Liu Z, Mehta SJ, Lee KS, Grossman B, Qu H, Gu X, Nichol GS, Hruby VJ. Thio-Claisen rearrangement used in preparing anti-β-functionalized γ,δ-unsaturated amino acids: scope and limitations. The Journal of Organic Chemistry. 77: 1289-300. PMID 22283513 DOI: 10.1021/jo201753q  1
2012 Liu Z, Mehta SJ, Hruby VJ. Strategies for asymmetric synthesis of amino acids withγ,δ -Unsaturation Organic Preparations and Procedures International. 44: 222-255. DOI: 10.1080/00304948.2012.676507  1
2011 Vardanyan RS, Danagulyan GG, Mkrtchyan AD, Hruby VJ. Recyclization reactions of 1-alkylpyrimidinium salts. Heterocyclic Communications. 17: 129-133. PMID 25400328 DOI: 10.1515/hc.2011.025  1
2011 Hruby VJ, Cai M, Nyberg J, Muthu D. Approaches to the rational design of selective melanocortin receptor antagonists. Expert Opinion On Drug Discovery. 6: 543-57. PMID 22646078 DOI: 10.1517/17460441.2011.565743  1
2011 Barkey NM, Tafreshi NK, Josan JS, De Silva CR, Sill KN, Hruby VJ, Gillies RJ, Morse DL, Vagner J. Development of melanoma-targeted polymer micelles by conjugation of a melanocortin 1 receptor (MC1R) specific ligand. Journal of Medicinal Chemistry. 54: 8078-84. PMID 22011200 DOI: 10.1021/jm201226w  1
2011 Brabez N, Lynch RM, Xu L, Gillies RJ, Chassaing G, Lavielle S, Hruby VJ. Design, synthesis, and biological studies of efficient multivalent melanotropin ligands: tools toward melanoma diagnosis and treatment. Journal of Medicinal Chemistry. 54: 7375-84. PMID 21928837 DOI: 10.1021/jm2009937  1
2011 Vardanyan R, Kumirov VK, Nichol GS, Davis P, Liktor-Busa E, Rankin D, Varga E, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands. Bioorganic & Medicinal Chemistry. 19: 6135-42. PMID 21925887 DOI: 10.1016/j.bmc.2011.08.027  1
2011 Grieco P, Brancaccio D, Novellino E, Hruby VJ, Carotenuto A. Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor. European Journal of Medicinal Chemistry. 46: 3721-33. PMID 21652123 DOI: 10.1016/j.ejmech.2011.05.038  1
2011 Josan JS, Handl HL, Sankaranarayanan R, Xu L, Lynch RM, Vagner J, Mash EA, Hruby VJ, Gillies RJ. Cell-specific targeting by heterobivalent ligands. Bioconjugate Chemistry. 22: 1270-8. PMID 21639139 DOI: 10.1021/bc1004284  1
2011 Hanlon KE, Herman DS, Agnes RS, Largent-Milnes TM, Kumarasinghe IR, Ma SW, Guo W, Lee YS, Ossipov MH, Hruby VJ, Lai J, Porreca F, Vanderah TW. Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain. Brain Research. 1395: 1-11. PMID 21550594 DOI: 10.1016/j.brainres.2011.04.024  1
2011 Wu Z, Hruby VJ. Backbone alignment modeling of the structure-activity relationships of opioid ligands. Journal of Chemical Information and Modeling. 51: 1151-64. PMID 21488692 DOI: 10.1021/ci2000852  1
2011 Mayorov AV, Cai M, Palmer ES, Tanaka DK, Cain JP, Dedek MM, Tan B, Trivedi D, Hruby VJ. Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 21: 3099-102. PMID 21486697 DOI: 10.1016/j.bmcl.2011.03.019  1
2011 Yamamoto T, Nair P, Largent-Milnes TM, Jacobsen NE, Davis P, Ma SW, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. Journal of Medicinal Chemistry. 54: 2029-38. PMID 21366266 DOI: 10.1021/jm101023r  1
2011 Josan JS, De Silva CR, Yoo B, Lynch RM, Pagel MD, Vagner J, Hruby VJ. Fluorescent and lanthanide labeling for ligand screens, assays, and imaging. Methods in Molecular Biology (Clifton, N.J.). 716: 89-126. PMID 21318902 DOI: 10.1007/978-1-61779-012-6_6  1
2011 Cai M, Liu Z, Qu H, Fan H, Zheng Z, Hruby VJ. Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma. European Journal of Pharmacology. 660: 188-93. PMID 21315067 DOI: 10.1016/j.ejphar.2011.01.032  1
2011 Hruby VJ, Cai M, Cain J, Nyberg J, Trivedi D. Design of novel melanocortin receptor ligands: multiple receptors, complex pharmacology, the challenge. European Journal of Pharmacology. 660: 88-93. PMID 21208601 DOI: 10.1016/j.ejphar.2010.10.109  1
2011 Lee YS, Kulkarani V, Cowell SM, Ma SW, Davis P, Hanlon KE, Vanderah TW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of potent μ and δ opioid agonists with high lipophilicity. Journal of Medicinal Chemistry. 54: 382-6. PMID 21128594 DOI: 10.1021/jm100982d  1
2011 Mollica A, Pinnen F, Feliciani F, Stefanucci A, Lucente G, Davis P, Porreca F, Ma SW, Lai J, Hruby VJ. New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4' positions and non-hydrazine linkers. Amino Acids. 40: 1503-11. PMID 20924622 DOI: 10.1007/s00726-010-0760-7  1
2011 Vardanyan R, Kumirov VK, Hruby VJ. Improved synthesis of d,l-fluorocitric acid Journal of Fluorine Chemistry. 132: 920-924. DOI: 10.1016/j.jfluchem.2011.07.006  1
2011 Hruby VJ. Collaborations Between Chemists and Biologists Collaborative Computational Technologies For Biomedical Research. 113-120. DOI: 10.1002/9781118026038.ch7  1
2010 Nichol GS, Vardanyan R, Hruby VJ. Synthesis and Crystallographic Study of N'-(1-benzylpiperidin-4-yl)acetohydrazide. Journal of Chemical Crystallography. 40: 961-964. PMID 25505832 DOI: 10.1007/s10870-010-9771-1  1
2010 Nichol GS, Kumirov VK, Vardanyan R, Hruby VJ. Proton sharing and transfer in some zwitterionic compounds based on 4-oxo-4-((1-phenethylpiperidin-4-yl)(phenyl)amino)alcanoic acids. Crystengcomm / Rsc. 12: 3651-3657. PMID 25425961 DOI: 10.1039/B923698H  1
2010 Largent-Milnes TM, Yamamoto T, Nair P, Moulton JW, Hruby VJ, Lai J, Porreca F, Vanderah TW. Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. British Journal of Pharmacology. 161: 986-1001. PMID 20977451 DOI: 10.1111/j.1476-5381.2010.00824.x  1
2010 Giordano C, Sansone A, Masi A, Lucente G, Punzi P, Mollica A, Pinnen F, Feliciani F, Cacciatore I, Davis P, Lai J, Ma SW, Porreca F, Hruby V. Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. European Journal of Medicinal Chemistry. 45: 4594-600. PMID 20692738 DOI: 10.1016/j.ejmech.2010.07.022  1
2010 Mayorov AV, Cai M, Palmer ES, Liu Z, Cain JP, Vagner J, Trivedi D, Hruby VJ. Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors. Peptides. 31: 1894-905. PMID 20688117 DOI: 10.1016/j.peptides.2010.06.026  1
2010 Yamamoto T, Nair P, Jacobsen NE, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines. Journal of Medicinal Chemistry. 53: 5491-501. PMID 20617791 DOI: 10.1021/jm100157m  1
2010 Lee YS, Fernandes S, Kulkarani V, Mayorov A, Davis P, Ma SW, Brown K, Gillies RJ, Lai J, Porreca F, Hruby VJ. Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. Bioorganic & Medicinal Chemistry Letters. 20: 4080-4. PMID 20547453 DOI: 10.1016/j.bmcl.2010.05.078  1
2010 Morse DL, Balagurunathan Y, Hostetter G, Trissal M, Tafreshi NK, Burke N, Lloyd M, Enkemann S, Coppola D, Hruby VJ, Gillies RJ, Han H. Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray. Biochemical Pharmacology. 80: 748-54. PMID 20510208 DOI: 10.1016/j.bcp.2010.05.018  1
2010 Doedens L, Opperer F, Cai M, Beck JG, Dedek M, Palmer E, Hruby VJ, Kessler H. Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies. Journal of the American Chemical Society. 132: 8115-28. PMID 20496895 DOI: 10.1021/ja101428m  1
2010 Torino D, Mollica A, Pinnen F, Feliciani F, Lucente G, Fabrizi G, Portalone G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues. Journal of Medicinal Chemistry. 53: 4550-4. PMID 20476738 DOI: 10.1021/jm1001343  1
2010 Xu L, Vagner J, Alleti R, Rao V, Jagadish B, Morse DL, Hruby VJ, Gillies RJ, Mash EA. Synthesis and characterization of a Eu-DTPA-PEGO-MSH(4) derivative for evaluation of binding of multivalent molecules to melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 20: 2489-92. PMID 20304640 DOI: 10.1016/j.bmcl.2010.03.007  1
2010 Juni A, Cai M, Stankova M, Waxman AR, Arout C, Klein G, Dahan A, Hruby VJ, Mogil JS, Kest B. Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor. Anesthesiology. 112: 181-8. PMID 19996949 DOI: 10.1097/ALN.0b013e3181c53849  1
2010 De Silva CR, Vagner J, Lynch R, Gillies RJ, Hruby VJ. Optimization of time-resolved fluorescence assay for detection of europium-tetraazacyclododecyltetraacetic acid-labeled ligand-receptor interactions. Analytical Biochemistry. 398: 15-23. PMID 19852924 DOI: 10.1016/j.ab.2009.10.031  1
2010 Hruby VJ, Alves I, Cowell S, Salamon Z, Tollin G. Use of plasmon waveguide resonance (PWR) spectroscopy for examining binding, signaling and lipid domain partitioning of membrane proteins. Life Sciences. 86: 569-74. PMID 19281827 DOI: 10.1016/j.lfs.2009.02.027  1
2010 Liu Z, Qu H, Gu X, Lee KS, Grossman B, Kumirov VK, Hruby VJ. Novel anti-β-functionalized γ,δ-unsaturated amino acids via a thio-Claisen rearrangement Tetrahedron Letters. 51: 3518-3520. DOI: 10.1016/j.tetlet.2010.04.102  1
2009 Kumarasinghe IR, Hruby VJ, Nichol GS. 1-(4-Methoxy-phen-yl)-3-phenyl-1H-pyrazol-5-amine. Acta Crystallographica. Section E, Structure Reports Online. 65: o1170. PMID 21583972 DOI: 10.1107/S1600536809015463  1
2009 Yamamoto T, Nair P, Jacobsen NE, Vagner J, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 52: 5164-75. PMID 20560643 DOI: 10.1021/jm900473p  1
2009 Hruby VJ. Organic chemistry and biology: chemical biology through the eyes of collaboration. The Journal of Organic Chemistry. 74: 9245-64. PMID 20000552 DOI: 10.1021/jo901767e  1
2009 Yamamoto T, Nair P, Ma SW, Davis P, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety. Bioorganic & Medicinal Chemistry. 17: 7337-43. PMID 19762245 DOI: 10.1016/j.bmc.2009.08.035  1
2009 Yang Y, Hruby VJ, Chen M, Crasto C, Cai M, Harmon CM. Novel binding motif of ACTH analogues at the melanocortin receptors. Biochemistry. 48: 9775-84. PMID 19743876 DOI: 10.1021/bi900634e  1
2009 Cai M, Nyberg J, Hruby VJ. Melanotropins as drugs for the treatment of obesity and other feeding disorders: potential and problems. Current Topics in Medicinal Chemistry. 9: 554-63. PMID 19689365 DOI: 10.2174/156802609788897817  1
2009 Xu L, Vagner J, Josan J, Lynch RM, Morse DL, Baggett B, Han H, Mash EA, Hruby VJ, Gillies RJ. Enhanced targeting with heterobivalent ligands. Molecular Cancer Therapeutics. 8: 2356-65. PMID 19671749 DOI: 10.1158/1535-7163.MCT-08-1183  1
2009 Torino D, Mollica A, Pinnen F, Lucente G, Feliciani F, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue. Bioorganic & Medicinal Chemistry Letters. 19: 4115-8. PMID 19560919 DOI: 10.1016/j.bmcl.2009.06.008  1
2009 Vardanyan R, Vijay G, Nichol GS, Liu L, Kumarasinghe I, Davis P, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorganic & Medicinal Chemistry. 17: 5044-53. PMID 19540763 DOI: 10.1016/j.bmc.2009.05.065  1
2009 Kumarasinghe IR, Hruby VJ, Nichol GS. 3-[1-(4-Sulfamoylphenyl)-5-p-tolyl-1H-pyrazol-3-yl]propanoic acid and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl]propanoic acid-dichloromethane-diethyl ether-water (2/0.72/1/1). Acta Crystallographica. Section C, Crystal Structure Communications. 65: o296-9. PMID 19498242 DOI: 10.1107/S010827010901676X  1
2009 Salamon Z, Tollin G, Alves I, Hruby V. Chapter 6. Plasmon resonance methods in membrane protein biology applications to GPCR signaling. Methods in Enzymology. 461: 123-46. PMID 19480917 DOI: 10.1016/S0076-6879(09)05406-8  0.64
2009 Qu H, Cai M, Mayorov AV, Grieco P, Zingsheim M, Trivedi D, Hruby VJ. Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor. Journal of Medicinal Chemistry. 52: 3627-35. PMID 19473029 DOI: 10.1021/jm801300c  1
2009 Josan JS, Morse DL, Xu L, Trissal M, Baggett B, Davis P, Vagner J, Gillies RJ, Hruby VJ. Solid-phase synthetic strategy and bioevaluation of a labeled delta-opioid receptor ligand Dmt-Tic-Lys for in vivo imaging. Organic Letters. 11: 2479-82. PMID 19445485 DOI: 10.1021/ol900200k  1
2009 Nair P, Yamamoto T, Kulkarni V, Moye S, Navratilova E, Davis P, Largent T, Ma SW, Yamamura HI, Vanderah T, Lai J, Porreca F, Hruby VJ. Novel bifunctional peptides as opioid agonists and NK-1 antagonists. Advances in Experimental Medicine and Biology. 611: 537-8. PMID 19400302 DOI: 10.1007/978-0-387-73657-0_235  1
2009 Lee Y, Petrov R, Kulkarni V, Min BJ, Ma SW, Davis P, Oyarzo J, Vanderah T, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety. Advances in Experimental Medicine and Biology. 611: 517-8. PMID 19400292 DOI: 10.1007/978-0-387-73657-0_225  1
2009 Fernandes SM, Sankaranarayanan R, Xu L, Josan J, Vagner J, Gillies R, Hruby VJ. Synthesis of bivalent MSH ligands and evaluation of their binding to hMC4R using MSH lanthaligand. Advances in Experimental Medicine and Biology. 611: 433-4. PMID 19400253 DOI: 10.1007/978-0-387-73657-0_186  1
2009 Josan JS, Sankaranarayanan R, Handl HL, Fernandes S, Xu L, Vagner J, Gillies RJ, Hruby VJ. Heterobivalent ligands crosslink multiple cell-surface receptors--a step towards personal medicine. Advances in Experimental Medicine and Biology. 611: 413-4. PMID 19400245 DOI: 10.1007/978-0-387-73657-0_178  1
2009 Hruby VJ, Cai M, Dedek M, Qu H, Palmer E, Mayorov A, Trivedi D, Tsaprailis G, Yang Y. Peptide and non-peptide mimetics utilize different pathways for signal transduction. Advances in Experimental Medicine and Biology. 611: 305-7. PMID 19400204 DOI: 10.1007/978-0-387-73657-0_137  1
2009 Kessler H, Chatterjee J, Doedens L, Operrer F, Biron E, Hoyer D, Schmid H, Gilon C, Hruby VJ, Mierkes DF. New perspective in peptide chemistry by N-alkylation. Advances in Experimental Medicine and Biology. 611: 229-31. PMID 19400173 DOI: 10.1007/978-0-387-73657-0_106  1
2009 Kulkarni VV, Lee YS, Salibay C, Davis P, Ma SW, Porreca F, Hruby VJ. Novel analogues of bifunctional ligands for opioid and melanocortin 4 receptor. Advances in Experimental Medicine and Biology. 611: 195-6. PMID 19400157 DOI: 10.1007/978-0-387-73657-0_90  1
2009 Min BJ, Mayorov AV, Cai M, Palmer E, Hruby VJ. Design and parallel synthesis of new bicyclic small molecules for targeting the melanocortin receptors. Advances in Experimental Medicine and Biology. 611: 187-8. PMID 19400153 DOI: 10.1007/978-0-387-73657-0_86  1
2009 Kumarasinghe IR, Hruby VJ, Nichol GS. 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]propionic acid and the corresponding methyl ester. Acta Crystallographica. Section C, Crystal Structure Communications. 65: o163-6. PMID 19346614 DOI: 10.1107/S010827010900941X  1
2009 Yang Y, Cai M, Chen M, Qu H, McPherson D, Hruby V, Harmon CM. Key amino acid residues in the melanocortin-4 receptor for nonpeptide THIQ specific binding and signaling. Regulatory Peptides. 155: 46-54. PMID 19303903 DOI: 10.1016/j.regpep.2009.03.006  1
2009 Zhang W, Gardell S, Zhang D, Xie JY, Agnes RS, Badghisi H, Hruby VJ, Rance N, Ossipov MH, Vanderah TW, Porreca F, Lai J. Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. Brain : a Journal of Neurology. 132: 778-87. PMID 19050032 DOI: 10.1093/brain/awn330  1
2009 Chen M, Cai M, McPherson D, Hruby V, Harmon CM, Yang Y. Contribution of the transmembrane domain 6 of melanocortin-4 receptor to peptide [Pro5, DNal (2')8]-gamma-MSH selectivity. Biochemical Pharmacology. 77: 114-24. PMID 18930713 DOI: 10.1016/j.bcp.2008.09.023  1
2009 Liu Z, Qu H, Gu X, Min BJ, Nyberg J, Hruby VJ. Enantioselective synthesis of anti-β-substituted γ,δ- unsaturated amino acids: A highly selective asymmetric Thio-Claisen rearrangement (Organic Letters (2008) 10) Organic Letters. 11: 497. DOI: 10.1021/ol8027913  1
2008 Josan JS, Vagner J, Handl HL, Sankaranarayanan R, Gillies RJ, Hruby VJ. Solid-Phase Synthesis of Heterobivalent Ligands Targeted to Melanocortin and Cholecystokinin Receptors. International Journal of Peptide Research and Therapeutics. 14: 293-300. PMID 19714261 DOI: 10.1007/s10989-008-9150-3  1
2008 Min BJ, Gu X, Yamamoto T, Petrov RR, Qu H, Lee YS, Hruby VJ. Synthesis of a novel benzyl-octahydropyrazino[1,2-a]pyrimidin-6-one derivative as a convenient internal bicyclic peptidomimetic. Tetrahedron Letters. 49: 2316-2319. PMID 19340283 DOI: 10.1016/j.tetlet.2008.01.137  1
2008 Yamamoto T, Nair P, Jacobsen NE, Davis P, Ma SW, Navratilova E, Moye S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 6334-47. PMID 18821747 DOI: 10.1021/jm800389v  1
2008 Balagurunathan Y, Morse DL, Hostetter G, Shanmugam V, Stafford P, Shack S, Pearson J, Trissal M, Demeure MJ, Von Hoff DD, Hruby VJ, Gillies RJ, Han H. Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer. Molecular Cancer Therapeutics. 7: 3071-80. PMID 18765825 DOI: 10.1158/1535-7163.MCT-08-0402  1
2008 Liu Z, Qu H, Gu X, Min BJ, Nichol GS, Nyberg J, Hruby VJ. Enantioselective synthesis of anti-beta-substituted gamma,delta-unsaturated amino acids: a highly selective asymmetric thio-Claisen rearrangement. Organic Letters. 10: 4105-8. PMID 18702500 DOI: 10.1021/ol801657q  1
2008 Agnes RS, Ying J, Kövér KE, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Peptides. 29: 1413-23. PMID 18502541 DOI: 10.1016/j.peptides.2008.03.022  1
2008 Vagner J, Qu H, Hruby VJ. Peptidomimetics, a synthetic tool of drug discovery. Current Opinion in Chemical Biology. 12: 292-6. PMID 18423417 DOI: 10.1016/j.cbpa.2008.03.009  1
2008 Grieco P, Cai M, Liu L, Mayorov A, Chandler K, Trivedi D, Lin G, Campiglia P, Novellino E, Hruby VJ. Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists. Journal of Medicinal Chemistry. 51: 2701-7. PMID 18412316 DOI: 10.1021/jm701181n  1
2008 Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 1369-76. PMID 18266313 DOI: 10.1021/jm070332f  1
2008 Vagner J, Xu L, Handl HL, Josan JS, Morse DL, Mash EA, Gillies RJ, Hruby VJ. Heterobivalent ligands crosslink multiple cell-surface receptors: the human melanocortin-4 and delta-opioid receptors. Angewandte Chemie (International Ed. in English). 47: 1685-8. PMID 18205159 DOI: 10.1002/anie.200702770  1
2008 Georgieva T, Devanathan S, Stropova D, Park CK, Salamon Z, Tollin G, Hruby VJ, Roeske WR, Yamamura HI, Varga E. Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling. European Journal of Pharmacology. 581: 19-29. PMID 18162180 DOI: 10.1016/j.ejphar.2007.11.053  1
2008 Lee M, Kim A, Conwell IM, Hruby V, Mayorov A, Cai M, Wardlaw SL. Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression. Peptides. 29: 440-7. PMID 18155809 DOI: 10.1016/j.peptides.2007.11.005  1
2008 Mayorov AV, Cai M, Palmer ES, Dedek MM, Cain JP, Van Scoy AR, Tan B, Vagner J, Trivedi D, Hruby VJ. Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor. Journal of Medicinal Chemistry. 51: 187-95. PMID 18088090 DOI: 10.1021/jm070461w  1
2008 Sutton GM, Josephine Babin M, Gu X, Hruby VJ, Butler AA. A derivative of the melanocortin receptor antagonist SHU9119 (PG932) increases food intake when administered peripherally. Peptides. 29: 104-11. PMID 18054119 DOI: 10.1016/j.peptides.2007.10.014  1
2008 Lee YS, Agnes RS, Cain JP, Kulkarni V, Cai M, Salibay C, Ciano K, Petrov R, Mayorov A, Vagner J, Trivedi D, Davis P, Ma SW, Lai J, Porreca F, ... ... Hruby VJ, et al. Opioid and melanocortin receptors: do they have overlapping pharmacophores? Biopolymers. 90: 433-8. PMID 17657709 DOI: 10.1002/bip.20814  1
2008 Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. New paradigms and tools in drug design for pain and addiction Drug Addiction: From Basic Research to Therapy. 477-494. DOI: 10.1007/978-0-387-76678-2_28  1
2008 Hadley ME, Heward CB, Hruby VJ, Sawyer TK, Yang YCS. Biological Actions of Melanocyte-Stimulating Hormone Peptides of the Pars Intermedia. 244-262. DOI: 10.1002/9780470720646.ch14  1
2007 Lee YS, Petrov R, Park CK, Ma SW, Davis P, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. Journal of Medicinal Chemistry. 50: 5528-32. PMID 17927164 DOI: 10.1021/jm061465o  1
2007 Hruby VJ, Tollin G. Plasmon-waveguide resonance (PWR) spectroscopy for directly viewing rates of GPCR/G-protein interactions and quantifying affinities. Current Opinion in Pharmacology. 7: 507-14. PMID 17869585 DOI: 10.1016/j.coph.2007.08.001  1
2007 Qu H, Gu X, Liu Z, Min BJ, Hruby VJ. Asymmetric Eschenmoser-Claisen rearrangement for anti-beta-substituted gamma,delta-unsaturated amino acids. Organic Letters. 9: 3997-4000. PMID 17760455 DOI: 10.1021/ol701704h  1
2007 Handl HL, Sankaranarayanan R, Josan JS, Vagner J, Mash EA, Gillies RJ, Hruby VJ. Synthesis and evaluation of bivalent NDP-alpha-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R). Bioconjugate Chemistry. 18: 1101-9. PMID 17591746 DOI: 10.1021/bc0603642  1
2007 Hruby VJ. Professor Mac E. Hadley: creative scientist, superb teacher, dynamic collaborator and wonderful friend. General and Comparative Endocrinology. 151: 358-60. PMID 17590901 DOI: 10.1016/j.ygcen.2007.02.033  1
2007 King SH, Mayorov AV, Balse-Srinivasan P, Hruby VJ, Vanderah TW, Wessells H. Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry. 7: 1098-1106. PMID 17584130  1
2007 Hruby VJ, Cai M, Cain JP, Mayorov AV, Dedek MM, Trivedi D. Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor. Current Topics in Medicinal Chemistry. 7: 1107-19. PMID 17584128 DOI: 10.2174/156802607780906654  1
2007 Chen M, Cai M, Aprahamian CJ, Georgeson KE, Hruby V, Harmon CM, Yang Y. Contribution of the conserved amino acids of the melanocortin-4 receptor in [corrected] [Nle4,D-Phe7]-alpha-melanocyte-stimulating [corrected] hormone binding and signaling. The Journal of Biological Chemistry. 282: 21712-9. PMID 17545153 DOI: 10.1074/jbc.M702285200  1
2007 Mollica A, Guardiani G, Davis P, Ma SW, Porreca F, Lai J, Mannina L, Sobolev AP, Hruby VJ. Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. Journal of Medicinal Chemistry. 50: 3138-42. PMID 17539621 DOI: 10.1021/jm061048b  1
2007 Yamamoto T, Nair P, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Vanderah TW, Yamamura HI, Porreca F, Hruby VJ. Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists. Journal of Medicinal Chemistry. 50: 2779-86. PMID 17516639 DOI: 10.1021/jm061369n  1
2007 Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 28: 1191-6. PMID 17482720 DOI: 10.1016/j.peptides.2007.02.012  1
2007 Jagadish B, Sankaranarayanan R, Xu L, Richards R, Vagner J, Hruby VJ, Gillies RJ, Mash EA. Squalene-derived flexible linkers for bioactive peptides. Bioorganic & Medicinal Chemistry Letters. 17: 3310-3. PMID 17448660 DOI: 10.1016/j.bmcl.2007.04.001  1
2007 Zhou M, Nakatani E, Gronenberg LS, Tokimoto T, Wirth MJ, Hruby VJ, Roberts A, Lynch RM, Ghosh I. Peptide-labeled quantum dots for imaging GPCRs in whole cells and as single molecules. Bioconjugate Chemistry. 18: 323-32. PMID 17373766 DOI: 10.1021/bc0601929  1
2007 Lee YS, Nyberg J, Moye S, Agnes RS, Davis P, Ma SW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors. Bioorganic & Medicinal Chemistry Letters. 17: 2161-5. PMID 17329100 DOI: 10.1016/j.bmcl.2007.01.114  1
2007 Navratilova E, Waite S, Stropova D, Eaton MC, Alves ID, Hruby VJ, Roeske WR, Yamamura HI, Varga EV. Quantitative evaluation of human delta opioid receptor desensitization using the operational model of drug action. Molecular Pharmacology. 71: 1416-26. PMID 17322005 DOI: 10.1124/mol.106.030023  1
2007 Ballet S, Mayorov AV, Cai M, Tymecka D, Chandler KB, Palmer ES, Rompaey KV, Misicka A, Tourwé D, Hruby VJ. Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold. Bioorganic & Medicinal Chemistry Letters. 17: 2492-8. PMID 17314042 DOI: 10.1016/j.bmcl.2007.02.020  1
2007 Bowen ME, Monguchi Y, Sankaranarayanan R, Vagner J, Begay LJ, Xu L, Jagadish B, Hruby VJ, Gillies RJ, Mash EA. Design, synthesis, and validation of a branched flexible linker for bioactive peptides. The Journal of Organic Chemistry. 72: 1675-80. PMID 17279799 DOI: 10.1021/jo0704412  1
2007 Lee YS, Agnes RS, Davis P, Ma SW, Badghisi H, Lai J, Porreca F, Hruby VJ. Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. Journal of Medicinal Chemistry. 50: 165-8. PMID 17201419 DOI: 10.1021/jm061268p  1
2007 Shinoda K, Hruby VJ, Porreca F. Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors. Neuroscience Letters. 411: 143-6. PMID 17110034 DOI: 10.1016/j.neulet.2006.10.027  1
2006 Hruby VJ, Vagner J. High throughput synthesis of peptides and peptidomimetics. Chimica Oggi. 24: 18-21. PMID 18618009  1
2006 Qu H, Carducci MD, Nichol GS, Hruby VJ. (1R,2S)-Benzyl N-[3-(diisopropylaminocarbonyl)-2-phenylprop-3-enyl]carbamate. Acta Crystallographica. Section E, Structure Reports Online. 62: o3921-o3922. PMID 17710225 DOI: 10.1107/S1600536806032041  1
2006 Petrov RR, Vardanyan RS, Nichol GS, Carducci MD, Ma SW, Lai JY, Hruby VJ. 4-{N-[2-(1,3-Dioxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl]anilino}-1-phenethylpiperidinium chloride methanol disolvate. Acta Crystallographica. Section E, Structure Reports Online. 62: o2815-o2816. PMID 17268579 DOI: 10.1107/S1600536806021817  1
2006 Carducci MD, Gu X, Cole JR, Hruby VJ. [N-({(R)-2-[(N-Benzylprolyl)amino]phenyl}-phenylmethylene)-2(S)-(pent-4-enyl)-glycinato]nickel(II). Acta Crystallographica. Section E, Structure Reports Online. 62: m1219-m1220. PMID 17268578 DOI: 10.1107/S160053680601244X  1
2006 Ndungu JM, Cain JP, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides. Tetrahedron Letters. 47: 2233-2236. PMID 17203138 DOI: 10.1016/j.tetlet.2006.01.096  1
2006 Ying J, Gu X, Cai M, Dedek M, Vagner J, Trivedi DB, Hruby VJ. Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor. Journal of Medicinal Chemistry. 49: 6888-96. PMID 17154518 DOI: 10.1021/jm060768f  1
2006 Cai M, Varga EV, Stankova M, Mayorov A, Perry JW, Yamamura HI, Trivedi D, Hruby VJ. Cell signaling and trafficking of human melanocortin receptors in real time using two-photon fluorescence and confocal laser microscopy: differentiation of agonists and antagonists. Chemical Biology & Drug Design. 68: 183-93. PMID 17105482 DOI: 10.1111/j.1747-0285.2006.00432.x  1
2006 Vagner J, Handl HL, Monguchi Y, Jana U, Begay LJ, Mash EA, Hruby VJ, Gillies RJ. Rigid linkers for bioactive peptides. Bioconjugate Chemistry. 17: 1545-50. PMID 17105235 DOI: 10.1021/bc060154p  1
2006 Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. New paradigms and tools in drug design for pain and addiction. The Aaps Journal. 8: E450-60. PMID 17025262 DOI: 10.1208/aapsj080353  1
2006 Qu H, Gu X, Min BJ, Liu Z, Hruby VJ. Synthesis of Anti-beta-substituted gamma,delta-unsaturated amino acids via Eschenmoser-Claisen rearrangement. Organic Letters. 8: 4215-8. PMID 16956190 DOI: 10.1021/ol061414l  1
2006 Cain JP, Mayorov AV, Cai M, Wang H, Tan B, Chandler K, Lee Y, Petrov RR, Trivedi D, Hruby VJ. Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 16: 5462-7. PMID 16931008 DOI: 10.1016/j.bmcl.2006.07.015  1
2006 Hen G, Yosefi S, Simchaev V, Shinder D, Hruby VJ, Friedman-Einat M. The melanocortin circuit in obese and lean strains of chicks. The Journal of Endocrinology. 190: 527-35. PMID 16899585 DOI: 10.1677/joe.1.06783  1
2006 Petrov RR, Vardanyan RS, Lee YS, Ma SW, Davis P, Begay LJ, Lai JY, Porreca F, Hruby VJ. Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity. Bioorganic & Medicinal Chemistry Letters. 16: 4946-50. PMID 16828552 DOI: 10.1016/j.bmcl.2006.06.040  1
2006 Mayorov AV, Han SY, Cai M, Hammer MR, Trivedi D, Hruby VJ. Effects of macrocycle size and rigidity on melanocortin receptor-1 and -5 selectivity in cyclic lactam alpha-melanocyte-stimulating hormone analogs. Chemical Biology & Drug Design. 67: 329-35. PMID 16784457 DOI: 10.1111/j.1747-0285.2006.00383.x  1
2006 Agnes RS, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Journal of Medicinal Chemistry. 49: 2868-75. PMID 16686530 DOI: 10.1021/jm050921q  1
2006 Alves ID, Delaroche D, Mouillac B, Salamon Z, Tollin G, Hruby VJ, Lavielle S, Sagan S. The two NK-1 binding sites correspond to distinct, independent, and non-interconvertible receptor conformational states as confirmed by plasmon-waveguide resonance spectroscopy. Biochemistry. 45: 5309-18. PMID 16618119 DOI: 10.1021/bi052586d  1
2006 Mayorov AV, Cai M, Chandler KB, Petrov RR, Van Scoy AR, Yu Z, Tanaka DK, Trivedi D, Hruby VJ. Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. Journal of Medicinal Chemistry. 49: 1946-52. PMID 16539382 DOI: 10.1021/jm0510326  1
2006 Lee YS, Agnes RS, Badghisi H, Davis P, Ma SW, Lai J, Porreca F, Hruby VJ. Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. Journal of Medicinal Chemistry. 49: 1773-80. PMID 16509592 DOI: 10.1021/jm050851n  1
2006 Grieco P, Cai M, Mayorov AV, Trivedi D, Hruby VJ. Structure-activity studies of new melanocortin peptides containing an aromatic amino acid at the N-terminal position. Peptides. 27: 472-81. PMID 16303211 DOI: 10.1016/j.peptides.2005.01.032  1
2006 Mollica A, Davis P, Ma SW, Porreca F, Lai J, Hruby VJ. Synthesis and biological activity of the first cyclic biphalin analogues. Bioorganic & Medicinal Chemistry Letters. 16: 367-72. PMID 16275086 DOI: 10.1016/j.bmcl.2005.09.080  1
2006 Marks DL, Hruby V, Brookhart G, Cone RD. The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R). Peptides. 27: 259-64. PMID 16274853 DOI: 10.1016/j.peptides.2005.01.025  1
2006 Vardanyan RS, Hruby VJ. Synthesis of Essential Drugs Synthesis of Essential Drugs.  1
2005 Vardanyan RS, Hruby VJ, Danagulyan GG, Mkrtchyan AD. Isomerization/Recyclization of some 5-Ethoxycarbonyl-pyrimidines. Journal of Heterocyclic Chemistry. 42: 557-562. PMID 16467919  1
2005 Vessey KA, Lencses KA, Rushforth DA, Hruby VJ, Stell WK. Glucagon receptor agonists and antagonists affect the growth of the chick eye: a role for glucagonergic regulation of emmetropization? Investigative Ophthalmology & Visual Science. 46: 3922-31. PMID 16249465 DOI: 10.1167/iovs.04-1026  1
2005 Soloshonok VA, Cai C, Yamada T, Ueki H, Ohfune Y, Hruby VJ. Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographically controlled stereoselectivity. Journal of the American Chemical Society. 127: 15296-303. PMID 16248672 DOI: 10.1021/ja0535561  1
2005 Smith EA, Coym JW, Cowell SM, Tokimoto T, Hruby VJ, Yamamura HI, Wirth MJ. Lipid bilayers on polyacrylamide brushes for inclusion of membrane proteins. Langmuir : the Acs Journal of Surfaces and Colloids. 21: 9644-50. PMID 16207048 DOI: 10.1021/la051116h  1
2005 Liu J, Ying J, Chow VT, Hruby VJ, Satyanarayanajois SD. Structure-activity studies of peptides from the "hot-spot" region of human CD2 protein: development of peptides for immunomodulation. Journal of Medicinal Chemistry. 48: 6236-49. PMID 16190751 DOI: 10.1021/jm0503547  1
2005 Alves ID, Park CK, Hruby VJ. Plasmon resonance methods in GPCR signaling and other membrane events. Current Protein & Peptide Science. 6: 293-312. PMID 16101432 DOI: 10.2174/1389203054546352  1
2005 Fung S, Hruby VJ. Design of cyclic and other templates for potent and selective peptide alpha-MSH analogues. Current Opinion in Chemical Biology. 9: 352-8. PMID 16023401 DOI: 10.1016/j.cbpa.2005.06.010  1
2005 Handl HL, Vagner J, Yamamura HI, Hruby VJ, Gillies RJ. Development of a lanthanide-based assay for detection of receptor-ligand interactions at the delta-opioid receptor. Analytical Biochemistry. 343: 299-307. PMID 16004955 DOI: 10.1016/j.ab.2005.05.040  1
2005 Alves ID, Salamon Z, Hruby VJ, Tollin G. Ligand modulation of lateral segregation of a G-protein-coupled receptor into lipid microdomains in sphingomyelin/phosphatidylcholine solid-supported bilayers. Biochemistry. 44: 9168-78. PMID 15966741 DOI: 10.1021/BI068005H  1
2005 King T, Gardell LR, Wang R, Vardanyan A, Ossipov MH, Malan TP, Vanderah TW, Hunt SP, Hruby VJ, Lai J, Porreca F. Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain. 116: 276-88. PMID 15964684 DOI: 10.1016/j.pain.2005.04.014  1
2005 Cai M, Mayorov AV, Ying J, Stankova M, Trivedi D, Cabello C, Hruby VJ. Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors. Peptides. 26: 1481-5. PMID 15876475 DOI: 10.1016/j.peptides.2005.03.020  1
2005 Hsu R, Taylor JR, Newton SS, Alvaro JD, Haile C, Han G, Hruby VJ, Nestler EJ, Duman RS. Blockade of melanocortin transmission inhibits cocaine reward. The European Journal of Neuroscience. 21: 2233-42. PMID 15869520 DOI: 10.1111/j.1460-9568.2005.04038.x  1
2005 Mollica A, Davis P, Ma SW, Lai J, Porreca F, Hruby VJ. Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers. Bioorganic & Medicinal Chemistry Letters. 15: 2471-5. PMID 15863299 DOI: 10.1016/j.bmcl.2005.03.067  1
2005 Devanathan S, Salamon Z, Nagar A, Narang S, Schleich D, Darman P, Hruby V, Tollin G. Subpicomolar sensing of delta-opioid receptor ligands by molecular-imprinted polymers using plasmon-waveguide resonance spectroscopy. Analytical Chemistry. 77: 2569-74. PMID 15828795 DOI: 10.1021/ac048476e  1
2005 Dhanasekaran M, Palian MM, Alves I, Yeomans L, Keyari CM, Davis P, Bilsky EJ, Egleton RD, Yamamura HI, Jacobsen NE, Tollin G, Hruby VJ, Porreca F, Polt R. Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers. Journal of the American Chemical Society. 127: 5435-48. PMID 15826181 DOI: 10.1021/ja0432158  1
2005 Subramaniam V, Alves ID, Salgado GF, Lau PW, Wysocki RJ, Salamon Z, Tollin G, Hruby VJ, Brown MF, Saavedra SS. Rhodopsin reconstituted into a planar-supported lipid bilayer retains photoactivity after cross-linking polymerization of lipid monomers. Journal of the American Chemical Society. 127: 5320-1. PMID 15826160 DOI: 10.1021/ja0423973  1
2005 Cai M, Mayorov AV, Cabello C, Stankova M, Trivedi D, Hruby VJ. Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues. Journal of Medicinal Chemistry. 48: 1839-48. PMID 15771429 DOI: 10.1021/jm049579s  1
2005 Lin J, Liao S, Hruby VJ. Syntheses of optically pure, conformationally constrained, and highly hydrophobic unusual amino acids: 2-amino-3, 3-diarylpropionic acids. The Journal of Peptide Research : Official Journal of the American Peptide Society. 65: 105-12. PMID 15686541 DOI: 10.1111/j.1399-3011.2004.00194.x  1
2005 Gu X, Ying J, Min B, Cain JP, Davis P, Willey P, Navratilova E, Yamamura HI, Porreca F, Hruby VJ. Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues. Biopolymers. 80: 151-63. PMID 15660379 DOI: 10.1002/bip.20208  1
2005 Alves ID, Salgado GF, Salamon Z, Brown MF, Tollin G, Hruby VJ. Phosphatidylethanolamine enhances rhodopsin photoactivation and transducin binding in a solid supported lipid bilayer as determined using plasmon-waveguide resonance spectroscopy. Biophysical Journal. 88: 198-210. PMID 15501933 DOI: 10.1529/biophysj.104.046722  1
2005 Hruby VJ. On the topic of peptide research and drug discovery Journal of Peptide Research. 66: 309-310. DOI: 10.1111/j.1399-3011.2005.00307.x  1
2005 Monguchi Y, Vagner J, Handl HL, Jana U, Begay LJ, Hruby VJ, Gillies RJ, Mash EA. Design, synthesis, and validation of rigid linkers for bioactive peptides Tetrahedron Letters. 46: 7589-7592. DOI: 10.1016/j.tetlet.2005.08.151  1
2005 Hruby VJ, Lawson S. Where are the science heroes? [3] (multiple letters) Scientist. 19: 8.  1
2004 Handl HL, Vagner J, Han H, Mash E, Hruby VJ, Gillies RJ. Hitting multiple targets with multimeric ligands. Expert Opinion On Therapeutic Targets. 8: 565-86. PMID 15584863 DOI: 10.1517/14728222.8.6.565  1
2004 Cowell SM, Lee YS, Cain JP, Hruby VJ. Exploring Ramachandran and chi space: conformationally constrained amino acids and peptides in the design of bioactive polypeptide ligands. Current Medicinal Chemistry. 11: 2785-98. PMID 15544476  1
2004 Ossipov MH, Lai J, King T, Vanderah TW, Malan TP, Hruby VJ, Porreca F. Antinociceptive and nociceptive actions of opioids. Journal of Neurobiology. 61: 126-48. PMID 15362157 DOI: 10.1002/neu.20091  1
2004 Gu X, Ying J, Agnes RS, Navratilova E, Davis P, Stahl G, Porreca F, Yamamura HI, Hruby VJ. Novel design of bicyclic beta-turn dipeptides on solid-phase supports and synthesis of [3.3.0]-Bicyclo([2,3])-leu-enkephalin analogues. Organic Letters. 6: 3285-8. PMID 15355033 DOI: 10.1021/ol0488183  1
2004 Alves ID, Ciano KA, Boguslavski V, Varga E, Salamon Z, Yamamura HI, Hruby VJ, Tollin G. Selectivity, cooperativity, and reciprocity in the interactions between the delta-opioid receptor, its ligands, and G-proteins. The Journal of Biological Chemistry. 279: 44673-82. PMID 15317820 DOI: 10.1074/jbc.M404713200  1
2004 Soloshonok VA, Ueki H, Tiwari R, Cai C, Hruby VJ. Virtually complete control of simple and face diastereoselectivity in the Michael addition reactions between achiral equivalents of a nucleophilic glycine and (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: practical method for preparation of beta-substituted pyroglutamic acids and prolines. The Journal of Organic Chemistry. 69: 4984-90. PMID 15255725 DOI: 10.1021/jo0495438  1
2004 Handl HL, Vagner J, Yamamura HI, Hruby VJ, Gillies RJ. Lanthanide-based time-resolved fluorescence of in cyto ligand-receptor interactions. Analytical Biochemistry. 330: 242-50. PMID 15203329 DOI: 10.1016/j.ab.2004.04.012  1
2004 Cai M, Stankova M, Pond SJ, Mayorov AV, Perry JW, Yamamura HI, Trivedi D, Hruby VJ. Real time differentiation of G-protein coupled receptor (GPCR) agonist and antagonist by two photon fluorescence laser microscopy. Journal of the American Chemical Society. 126: 7160-1. PMID 15186137 DOI: 10.1021/ja049473m  1
2004 Elmagbari NO, Egleton RD, Palian MM, Lowery JJ, Schmid WR, Davis P, Navratilova E, Dhanasekaran M, Keyari CM, Yamamura HI, Porreca F, Hruby VJ, Polt R, Bilsky EJ. Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides. The Journal of Pharmacology and Experimental Therapeutics. 311: 290-7. PMID 15166257 DOI: 10.1124/jpet.104.069393  1
2004 Lipkowski AW, Carr DB, Hruby VJ, Yoshikawa M. Is RNA-laden p24 capsid protein a vector for HIV? Medical Hypotheses. 62: 919-21. PMID 15142648 DOI: 10.1016/j.mehy.2003.12.035  1
2004 Alves I, Cowell S, Lee YS, Tang X, Davis P, Porreca F, Hruby VJ. A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid, CCK, and melanotropin ligands. Biochemical and Biophysical Research Communications. 318: 335-40. PMID 15120606 DOI: 10.1016/j.bbrc.2004.04.033  1
2004 Alves ID, Cowell SM, Salamon Z, Devanathan S, Tollin G, Hruby VJ. Different structural states of the proteolipid membrane are produced by ligand binding to the human delta-opioid receptor as shown by plasmon-waveguide resonance spectroscopy. Molecular Pharmacology. 65: 1248-57. PMID 15102953 DOI: 10.1124/mol.65.5.1248  1
2004 Cai M, Cai C, Mayorov AV, Xiong C, Cabello CM, Soloshonok VA, Swift JR, Trivedi D, Hruby VJ. Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity. The Journal of Peptide Research : Official Journal of the American Peptide Society. 63: 116-31. PMID 15009533 DOI: 10.1111/j.1399-3011.2003.00105.x  1
2004 Han G, Haskell-Luevano C, Kendall L, Bonner G, Hadley ME, Cone RD, Hruby VJ. De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach. Journal of Medicinal Chemistry. 47: 1514-26. PMID 14998337 DOI: 10.1021/jm030452x  1
2004 Vagner J, Handl HL, Gillies RJ, Hruby VJ. Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of alpha-MSH. Bioorganic & Medicinal Chemistry Letters. 14: 211-5. PMID 14684330 DOI: 10.1016/j.bmcl.2003.09.079  1
2004 Cai C, Yamada T, Tiwari R, Hruby VJ, Soloshonok VA. Application of (S)- and (R)-methyl pyroglutamates as inexpensive, yet highly efficient chiral auxiliaries in the asymmetric Michael addition reactions Tetrahedron Letters. 45: 6855-6858. DOI: 10.1016/j.tetlet.2004.07.096  1
2004 Ndungu JM, Gu X, Gross DE, Cain JP, Carducci MD, Hruby VJ. Synthesis of bicyclic dipeptide mimetics for the cholecystokinin and opioid receptors Tetrahedron Letters. 45: 4139-4142. DOI: 10.1016/j.tetlet.2004.03.146  1
2004 Ndungu JM, Gu X, Gross DE, Ying J, Hruby VJ. A simple and efficient synthesis of an Asp-Gly dipeptide mimetic Tetrahedron Letters. 45: 3245-3247. DOI: 10.1016/j.tetlet.2004.02.117  1
2004 Gu X, Ndungu JM, Qiu W, Ying J, Carducci MD, Wooden H, Hruby VJ. Large scale enantiomeric synthesis, purification, and characterization of ω-unsaturated amino acids via a Gly-Ni(II)-BPB-complex Tetrahedron. 60: 8233-8243. DOI: 10.1016/j.tet.2004.06.087  1
2003 Ying J, Kövér KE, Gu X, Han G, Trivedi DB, Kavarana MJ, Hruby VJ. Solution structures of cyclic melanocortin agonists and antagonists by NMR. Biopolymers. 71: 696-716. PMID 14991679 DOI: 10.1002/bip.10596  1
2003 Cowell SM, Gu X, Vagner J, Hruby VJ. Intelligent design in combinatorial chemistry: use of designed peptide libraries to explore secondary and tertiary structures in peptides and proteins. Methods in Enzymology. 369: 288-97. PMID 14722960 DOI: 10.1016/S0076-6879(03)69016-6  1
2003 Tollin G, Salamon Z, Hruby VJ. Techniques: plasmon-waveguide resonance (PWR) spectroscopy as a tool to study ligand-GPCR interactions. Trends in Pharmacological Sciences. 24: 655-9. PMID 14654307 DOI: 10.1016/j.tips.2003.10.010  0.44
2003 Balse-Srinivasan P, Grieco P, Cai M, Trivedi D, Hruby VJ. Structure-activity relationships of gamma-MSH analogues at the human melanocortin MC3, MC4, and MC5 receptors. Discovery of highly selective hMC3R, hMC4R, and hMC5R analogues. Journal of Medicinal Chemistry. 46: 4965-73. PMID 14584947 DOI: 10.1021/jm030119t  1
2003 Tollin G, Salamon Z, Cowell S, Hruby VJ. Plasmon-waveguide resonance spectroscopy: a new tool for investigating signal transduction by G-protein coupled receptors. Life Sciences. 73: 3307-11. PMID 14572873 DOI: 10.1016/j.lfs.2003.07.001  1
2003 Grieco P, Balse-Srinivasan P, Han G, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ. Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. The Journal of Peptide Research : Official Journal of the American Peptide Society. 62: 199-206. PMID 14531843 DOI: 10.1034/j.1399-3011.2003.00087.x  1
2003 Alves ID, Salamon Z, Varga E, Yamamura HI, Tollin G, Hruby VJ. Direct observation of G-protein binding to the human delta-opioid receptor using plasmon-waveguide resonance spectroscopy. The Journal of Biological Chemistry. 278: 48890-7. PMID 14522991 DOI: 10.1074/jbc.M306866200  1
2003 Hruby VJ. Peptide science: exploring the use of chemical principles and interdisciplinary collaboration for understanding life processes. Journal of Medicinal Chemistry. 46: 4215-31. PMID 13678399 DOI: 10.1021/jm0303103  1
2003 Zhang J, Xiong C, Ying J, Wang W, Hruby VJ. Stereoselective synthesis of novel dipeptide beta-turn mimetics targeting melanocortin peptide receptors. Organic Letters. 5: 3115-8. PMID 12916995 DOI: 10.1021/ol0351347  1
2003 Balse-Srinivasan P, Grieco P, Cai M, Trivedi D, Hruby VJ. Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R. Journal of Medicinal Chemistry. 46: 3728-33. PMID 12904077 DOI: 10.1021/jm030111j  1
2003 Xiong C, Zhang J, Davis P, Wang W, Ying J, Porreca F, Hruby VJ. Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted beta-turn bicyclic dipeptide mimetics. Chemical Communications (Cambridge, England). 1598-9. PMID 12868772 DOI: 10.1039/b302235h  1
2003 Wessells H, Hruby VJ, Hackett J, Han G, Balse-Srinivasan P, Vanderah TW. MT-II induces penile erection via brain and spinal mechanisms. Annals of the New York Academy of Sciences. 994: 90-5. PMID 12851302  1
2003 Hruby VJ, Cai M, Grieco P, Han G, Kavarana M, Trivedi D. Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors. Annals of the New York Academy of Sciences. 994: 12-20. PMID 12851293  1
2003 Hruby VJ, Agnes RS, Davis P, Ma SW, Lee YS, Vanderah TW, Lai J, Porreca F. Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain. Life Sciences. 73: 699-704. PMID 12801591 DOI: 10.1016/S0024-3205(03)00390-4  1
2003 Boguslavsky V, Hruby VJ, O'Brien DF, Misicka A, Lipkowski AW. Effect of peptide conformation on membrane permeability. The Journal of Peptide Research : Official Journal of the American Peptide Society. 61: 287-97. PMID 12753376  0.52
2003 Wessells H, Hruby VJ, Hackett J, Han G, Balse-Srinivasan P, Vanderah TW. Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors. Neuroscience. 118: 755-62. PMID 12710982 DOI: 10.1016/S0306-4522(02)00866-7  1
2003 Gillies RJ, Hruby VJ. Expression-driven reverse engineering of targeted imaging and therapeutic agents. Expert Opinion On Therapeutic Targets. 7: 137-9. PMID 12667092 DOI: 10.1517/14728222.7.2.137  1
2003 Mogil JS, Wilson SG, Chesler EJ, Rankin AL, Nemmani KV, Lariviere WR, Groce MK, Wallace MR, Kaplan L, Staud R, Ness TJ, Glover TL, Stankova M, Mayorov A, Hruby VJ, et al. The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proceedings of the National Academy of Sciences of the United States of America. 100: 4867-72. PMID 12663858 DOI: 10.1073/pnas.0730053100  1
2003 Varga EV, Rubenzik MK, Stropova D, Sugiyama M, Grife V, Hruby VJ, Rice KC, Roeske WR, Yamamura HI. Converging protein kinase pathways mediate adenylyl cyclase superactivation upon chronic delta-opioid agonist treatment. The Journal of Pharmacology and Experimental Therapeutics. 306: 109-15. PMID 12660310 DOI: 10.1124/jpet.103.049643  1
2003 Ying J, Ahn JM, Jacobsen NE, Brown MF, Hruby VJ. NMR solution structure of the glucagon antagonist [desHis1, desPhe6, Glu9]glucagon amide in the presence of perdeuterated dodecylphosphocholine micelles. Biochemistry. 42: 2825-35. PMID 12627948 DOI: 10.1021/bi026629r  1
2003 Han G, Quillan JM, Carlson K, Sadée W, Hruby VJ. Design of novel chimeric melanotropin-deltorphin analogues. Discovery of the first potent human melanocortin 1 receptor antagonist. Journal of Medicinal Chemistry. 46: 810-9. PMID 12593660 DOI: 10.1021/jm020355o  1
2003 Horais K, Hruby V, Rossi S, Cizkova D, Meschter C, Dorr R, Yaksh TL. Effects of chronic intrathecal infusion of a partial differential opioid agonist in dogs. Toxicological Sciences : An Official Journal of the Society of Toxicology. 71: 263-75. PMID 12563112 DOI: 10.1093/toxsci/71.2.263  1
2003 Hosohata K, Varga EV, Alfaro-Lopez J, Tang X, Vanderah TW, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. (2S,3R) beta-methyl-2',6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-L-Tic-OH] is a potent, selective delta-opioid receptor antagonist in mouse brain. The Journal of Pharmacology and Experimental Therapeutics. 304: 683-8. PMID 12538822 DOI: 10.1124/jpet.102.042929  1
2003 Okura T, Varga EV, Hosohata Y, Navratilova E, Cowell SM, Rice K, Nagase H, Hruby VJ, Roeske WR, Yamamura HI. Agonist-specific down-regulation of the human delta-opioid receptor. European Journal of Pharmacology. 459: 9-16. PMID 12505529 DOI: 10.1016/S0014-2999(02)02823-6  1
2003 Gu X, Cowell S, Ying J, Tang X, Hruby VJ. Synthesis of β-phenyl-δ,ε-unsaturated amino acids and stereoselective introduction of side chain groups into [4,3,0]-bicyclic β-turn dipeptides Tetrahedron Letters. 44: 5863-5866. DOI: 10.1016/S0040-4039(03)01383-2  1
2002 Salamon Z, Hruby VJ, Tollin G, Cowell S. Binding of agonists, antagonists and inverse agonists to the human delta-opioid receptor produces distinctly different conformational states distinguishable by plasmon-waveguide resonance spectroscopy. The Journal of Peptide Research : Official Journal of the American Peptide Society. 60: 322-8. PMID 12464110 DOI: 10.1034/j.1399-3011.2002.21060.x  1
2002 Grieco P, Lavecchia A, Cai M, Trivedi D, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ. Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors. Journal of Medicinal Chemistry. 45: 5287-94. PMID 12431055 DOI: 10.1021/jm0202526  1
2002 Zhang J, Xiong C, Wang W, Ying J, Hruby VJ. Stereoselective bromination-suzuki cross-coupling of dehydroamino acids to form novel reverse-turn peptidomimetics: substituted unsaturated and saturated indolizidinone amino acids. Organic Letters. 4: 4029-32. PMID 12423078  1
2002 Hruby VJ. Designing peptide receptor agonists and antagonists. Nature Reviews. Drug Discovery. 1: 847-58. PMID 12415245 DOI: 10.1038/nrd939  1
2002 Wang W, Yang J, Ying J, Xiong C, Zhang J, Cai C, Hruby VJ. Stereoselective synthesis of dipeptide beta-turn mimetics: 7-benzyl and 8-phenyl substituted azabicyclo[4.3.0]nonane amino acid esters. The Journal of Organic Chemistry. 67: 6353-60. PMID 12201753  1
2002 Kavarana MJ, Trivedi D, Cai M, Ying J, Hammer M, Cabello C, Grieco P, Han G, Hruby VJ. Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors. Journal of Medicinal Chemistry. 45: 2644-50. PMID 12036373 DOI: 10.1021/jm020021z  1
2002 Xiong C, Wang W, Hruby VJ. A general asymmetric synthesis of syn- and anti-beta-substituted cysteine and serine derivatives. The Journal of Organic Chemistry. 67: 3514-7. PMID 12003570 DOI: 10.1021/jo011172x  1
2002 Flippen-Anderson JL, Deschamps JR, George C, Hruby VJ, Misicka A, Lipkowski AW. Crystal structure of biphalin sulfate: a multireceptor opioid peptide. The Journal of Peptide Research : Official Journal of the American Peptide Society. 59: 123-33. PMID 11985706  0.52
2002 Grieco P, Balse-Srinivasan P, Han G, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ. Synthesis and biological evaluation on hMC3, hMC4 and hMC5 receptors of gamma-MSH analogs substituted with L-alanine. The Journal of Peptide Research : Official Journal of the American Peptide Society. 59: 203-10. PMID 11966977 DOI: 10.1034/j.1399-3011.2002.01966.x  1
2002 Grieco P, Han G, Weinberg D, Van der Ploeg LH, Hruby VJ. Design and synthesis of highly potent and selective melanotropin analogues of SHU9119 modified at position 6. Biochemical and Biophysical Research Communications. 292: 1075-80. PMID 11944925 DOI: 10.1006/bbrc.2002.6739  1
2002 Moens K, Berger V, Ahn JM, Van Schravendijk C, Hruby VJ, Pipeleers D, Schuit F. Assessment of the role of interstitial glucagon in the acute glucose secretory responsiveness of in situ pancreatic beta-cells. Diabetes. 51: 669-75. PMID 11872665  0.8
2002 Lipkowski AW, Misicka A, Kosson D, Kosson P, Lachwa-From M, Brodzik-Bienkowska A, Hruby VJ. Biological properties of a new fluorescent biphalin fragment analogue. Life Sciences. 70: 893-7. PMID 11853227  0.52
2002 Xiong C, Wang W, Cai C, Hruby VJ. Regioselective and stereoselective nucleophilic ring opening reactions of a phenyl-substituted aziridine: enantioselective synthesis of beta-substituted tryptophan, cysteine, and serine derivatives. The Journal of Organic Chemistry. 67: 1399-402. PMID 11846696  1
2002 Romanowski M, Zhu X, Kim K, Hruby VJ, O'Brien DF. Interaction of enkephalin peptides with anionic model membranes. Biochimica Et Biophysica Acta. 1558: 45-53. PMID 11750263 DOI: 10.1016/S0005-2736(01)00421-7  1
2002 Hruby VJ, Qui W, Okayama T, Soloshonok VA. Design of nonpeptides from peptide ligands for peptide receptors. Methods in Enzymology. 343: 91-123. PMID 11665597 DOI: 10.1016/S0076-6879(02)43129-1  1
2002 Hruby VJ, Agnes RS, Cai C. Design of peptide agonists. Methods in Enzymology. 343: 73-91. PMID 11665596 DOI: 10.1016/S0076-6879(02)43128-X  1
2002 Cowell SM, Balse-Srinivasan PM, Ahn JM, Hruby VJ. Design and synthesis of peptide antagonists and inverse agonists for G protein-coupled receptors. Methods in Enzymology. 343: 49-72. PMID 11665587 DOI: 10.1016/S0076-6879(02)43127-8  1
2002 Hruby VJ. NIDA/NIH symposium on 'Structural Biology and Structural Genomics/Proteomics' Journal of Peptide Research. 60: 305-306. DOI: 10.1034/j.1399-3011.2002.22002.x  1
2002 Paizs B, Suhai S, Hargittai B, Hruby VJ, Somogyi A. Ab initio and MS/MS studies on protonated peptides containing basic and acidic amino acid residues - I. Solvated proton vs. salt-bridged structures and the cleavage of the terminal amide bond of protonated RD-NH2 International Journal of Mass Spectrometry. 219: 203-232. DOI: 10.1016/S1387-3806(02)00560-2  1
2002 Gu X, Tang X, Cowell S, Ying J, Hruby VJ. A novel strategy toward [6,5]-bicyclic β-turn dipeptide Tetrahedron Letters. 43: 6669-6672. DOI: 10.1016/S0040-4039(02)01338-2  1
2002 Wang W, Cai M, Xiong C, Zhang J, Trivedi D, Hruby VJ. Design and synthesis of novel χ2-constrained phenylalanine, naphthylalanine, and tryptophan analogues and their use in biologically active melanotropin peptides Tetrahedron. 58: 7365-7374. DOI: 10.1016/S0040-4020(02)00588-4  1
2001 Han G, Tamaki M, Hruby VJ. Fast, efficient and selective deprotection of the tert-butoxycarbonyl (Boc) group using HCl/dioxane (4 m). The Journal of Peptide Research : Official Journal of the American Peptide Society. 58: 338-41. PMID 11606219 DOI: 10.1034/j.1399-3011.2001.00935.x  1
2001 Hruby VJ. Vincent duVigneaud 1901-1978: a personal tribute. The Journal of Peptide Research : Official Journal of the American Peptide Society. 58: 191-2. PMID 11576324 DOI: 10.1034/j.1399-3011.2001.00583.x  1
2001 Ahn JM, Gitu PM, Medeiros M, Swift JR, Trivedi D, Hruby VJ. A new approach to search for the bioactive conformation of glucagon: positional cyclization scanning. Journal of Medicinal Chemistry. 44: 3109-16. PMID 11543679  0.96
2001 Ahn JM, Medeiros M, Trivedi D, Hruby VJ. Development of potent glucagon antagonists: structure-activity relationship study of glycine at position 4. The Journal of Peptide Research : Official Journal of the American Peptide Society. 58: 151-8. PMID 11532074  0.96
2001 Tamaki M, Han G, Hruby VJ. Practical and efficient synthesis of orthogonally protected constrained 4-guanidinoprolines. The Journal of Organic Chemistry. 66: 1038-42. PMID 11430070 DOI: 10.1021/jo005626m  1
2001 Soloshonok VA, Tang X, Hruby VJ, Van Meervelt L. Asymmetric synthesis of alpha,beta-dialkyl-alpha-phenylalanines via direct alkylation of a chiral alanine derivative with racemic alpha-alkylbenzyl bromides. A case of high enantiomer differentiation at room temperature. Organic Letters. 3: 341-3. PMID 11428009 DOI: 10.1021/ol000330o  1
2001 Hosohata Y, Varga EV, Stropova D, Li X, Knapp RJ, Hruby VJ, Rice KC, Nagase H, Roeske WR, Yamamura HI. Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation. Life Sciences. 68: 2233-42. PMID 11358332 DOI: 10.1016/S0024-3205(01)01011-6  1
2001 Hruby VJ. Design in topographical space of peptide and peptidomimetic ligands that affect behavior. A chemist's glimpse at the mind--body problem. Accounts of Chemical Research. 34: 389-97. PMID 11352717 DOI: 10.1021/ar990063q  1
2001 Tamaki M, Han G, Hruby VJ. Synthesis of 4-cis-phenyl-L-proline via hydrogenolysis. The Journal of Organic Chemistry. 66: 3593-6. PMID 11348150 DOI: 10.1021/jo005625u  1
2001 Cai C, Soloshonok VA, Hruby VJ. Michael addition reactions between chiral Ni(II) complex of glycine and 3-(trans-enoyl)oxazolidin-2-ones. A case of electron donor-acceptor attractive interaction-controlled face diastereoselectivity. The Journal of Organic Chemistry. 66: 1339-50. PMID 11312965 DOI: 10.1021/jo0014865  1
2001 Ahn JM, Medeiros M, Trivedi D, Hruby VJ. Development of potent truncated glucagon antagonists. Journal of Medicinal Chemistry. 44: 1372-9. PMID 11311060  0.96
2001 Grieco P, Gitu PM, Hruby VJ. Preparation of 'side-chain-to-side-chain' cyclic peptides by Allyl and Alloc strategy: potential for library synthesis. The Journal of Peptide Research : Official Journal of the American Peptide Society. 57: 250-6. PMID 11298927 DOI: 10.1111/j.1399-3011.2001.00816.x  1
2001 Mitchell SA, Pratt MR, Hruby VJ, Polt R. Solid-phase synthesis of O-linked glycopeptide analogues of enkephalin Journal of Organic Chemistry. 66: 2327-2342. PMID 11281773 DOI: 10.1021/jo005712m  1
2001 Wang Z, Gardell LR, Ossipov MH, Vanderah TW, Brennan MB, Hochgeschwender U, Hruby VJ, Malan TP, Lai J, Porreca F. Pronociceptive actions of dynorphin maintain chronic neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1779-86. PMID 11222667  1
2001 Lipkowski AW, Misicka A, Hosohata K, Davis P, Yamamura HI, Porreca F, Hruby VJ. Biological properties of Phe(o)-opioid peptide analogues. Life Sciences. 68: 969-72. PMID 11213367 DOI: 10.1016/S0024-3205(00)00993-0  1
2001 Wang W, Xiong C, Yang J, Hruby VJ. Practical, asymmetric synthesis of aromatic-substituted bulky and hydrophobic tryptophan derivatives Tetrahedron Letters. 42: 7717-7719. DOI: 10.1016/S0040-4039(01)01626-4  1
2001 Han G, Hruby VJ. A study of conjugate addition to a γ,δ-dioxolanyl-α,β-unsaturated ester Tetrahedron Letters. 42: 4281-4283. DOI: 10.1016/S0040-4039(01)00719-5  1
2001 Han G, Lewis A, Hruby VJ. Synthesis of (2S,3S)-β-methyltryptophan Tetrahedron Letters. 42: 4601-4603. DOI: 10.1016/S0040-4039(01)00718-3  1
2001 Wang W, Xiong C, Hruby VJ. An efficient approach to asymmetric synthesis of dipeptide β-turn mimetics: Indolizidinone amino acids Tetrahedron Letters. 42: 3159-3161. DOI: 10.1016/S0040-4039(01)00409-9  1
2001 Hruby VJ, Soloshonok VA. Asymmetric synthesis of novel sterically constrained amino acids Tetrahedron. 57. DOI: 10.1016/S0040-4020(01)00498-7  1
2000 Grieco P, Balse PM, Weinberg D, MacNeil T, Hruby VJ. D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity. Journal of Medicinal Chemistry. 43: 4998-5002. PMID 11150170 DOI: 10.1021/JM000211E  0.72
2000 Salamon Z, Cowell S, Varga E, Yamamura HI, Hruby VJ, Tollin G. Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions. Biophysical Journal. 79: 2463-74. PMID 11053123 DOI: 10.1016/S0006-3495(00)76489-7  1
2000 Soloshonok VA, Cai C, Hruby VJ, Van Meervelt L, Yamazaki T. Rational design of highly diastereoselective, organic base-catalyzed, room-temperature Michael addition reactions. The Journal of Organic Chemistry. 65: 6688-96. PMID 11052120  1
2000 Egleton RD, Mitchell SA, Huber JD, Janders J, Stropova D, Polt R, Yamamura HI, Hruby VJ, Davis TP. Improved bioavailability to the brain of glycosylated Met-enkephalin analogs. Brain Research. 881: 37-46. PMID 11033091 DOI: 10.1016/S0006-8993(00)02794-3  1
2000 Wessells H, Gralnek D, Dorr R, Hruby VJ, Hadley ME, Levine N. Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology. 56: 641-6. PMID 11018622 DOI: 10.1016/S0090-4295(00)00680-4  0.76
2000 Balse PM, Kim HJ, Han G, Hruby VJ. Evaluation of new base-labile 2-(4-nitrophenylsulfonyl) ethoxycarbonyl (Nsc)-amino acids for solid-phase peptide synthesis. The Journal of Peptide Research : Official Journal of the American Peptide Society. 56: 70-9. PMID 10961541  1
2000 Soloshonok VA, Cai C, Hruby VJ. A Practical Asymmetric Synthesis of Enantiomerically Pure 3-Substituted Pyroglutamic Acids and Related Compounds This work was supported by grants from the U.S. Public Health Service (Grant DK 17420) and the National Institute of Drug Abuse (DA 06284 and DA 04248). The views expressed are those of the authors and not necessarily those of the USPHS. Angewandte Chemie (International Ed. in English). 39: 2172-2175. PMID 10941052 DOI: 10.1002/1521-3773(20000616)39:12<2172::AID-ANIE2172>3.0.CO;2-0  1
2000 Ko MC, Willmont KJ, Burritt A, Hruby VJ, Woods JH. Local inhibitory effects of dynorphin A-(1-17) on capsaicin-induced thermal allodynia in rhesus monkeys. European Journal of Pharmacology. 402: 69-76. PMID 10940359 DOI: 10.1016/S0014-2999(00)00503-3  1
2000 Hruby VJ. Peptide science--whither thou goest? The Journal of Peptide Research : Official Journal of the American Peptide Society. 56: 1-2. PMID 10917451 DOI: 10.1034/j.1399-3011.2000.056001001.x  1
2000 Hruby VJ, Balse PM. Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads. Current Medicinal Chemistry. 7: 945-70. PMID 10911024  1
2000 Okayama T, Burritt A, Hruby VJ. 4-Alkoxy-2-hydroxybenzaldehyde (AHB): a versatile aldehyde linker for solid-phase synthesis of C-terminal modified peptides and peptidomimetics. Organic Letters. 2: 1787-90. PMID 10891158  1
2000 Bilsky EJ, Egleton RD, Mitchell SA, Palian MM, Davis P, Huber JD, Jones H, Yamamura HI, Janders J, Davis TP, Porreca F, Hruby VJ, Polt R. Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability. Journal of Medicinal Chemistry. 43: 2586-90. PMID 10891118 DOI: 10.1021/jm000077y  1
2000 Witt KA, Slate CA, Egleton RD, Huber JD, Yamamura HI, Hruby VJ, Davis TP. Assessment of stereoselectivity of trimethylphenylalanine analogues of delta-opioid [D-Pen(2),D-Pen(5)]-enkephalin. Journal of Neurochemistry. 75: 424-35. PMID 10854288 DOI: 10.1046/j.1471-4159.2000.0750424.x  1
2000 Trivedi D, Lin Y, Ahn JM, Siegel M, Mollova NN, Schram KH, Hruby VJ. Design and synthesis of conformationally constrained glucagon analogues. Journal of Medicinal Chemistry. 43: 1714-22. PMID 10794689  0.96
2000 Shenderovich MD, Liao S, Qian X, Hruby VJ. A three-dimensional model of the delta-opioid pharmacophore: comparative molecular modeling of peptide and nonpeptide ligands. Biopolymers. 53: 565-80. PMID 10766952 DOI: 10.1002/(SICI)1097-0282(200006)53:7<565::AID-BIP4>3.0.CO;2-5  0.8
2000 Hosohata K, Logan JK, Varga E, Burkey TH, Vanderah TW, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. The role of the G protein gamma(2) subunit in opioid antinociception in mice. European Journal of Pharmacology. 392: R9-R11. PMID 10762674 DOI: 10.1016/S0014-2999(00)00132-1  1
2000 Soloshonok VA, Cai C, Hruby VJ. (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: ideal Michael acceptors to afford a virtually complete control of simple and face diastereoselectivity in addition reactions with glycine derivatives. Organic Letters. 2: 747-50. PMID 10754676  1
2000 Bilsky EJ, Qian X, Hruby VJ, Porreca F. Antinociceptive activity of [beta-methyl-2', 6'-dimethyltyrosine(1)]-substituted cyclic [D-Pen(2), D-Pen(5)]Enkephalin and [D-Ala(2),Asp(4)]Deltorphin analogs. The Journal of Pharmacology and Experimental Therapeutics. 293: 151-8. PMID 10734164  1
2000 Haskell-Luevano C, Lim S, Yuan W, Cone RD, Hruby VJ. Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions. Peptides. 21: 49-57. PMID 10704719 DOI: 10.1016/S0196-9781(99)00167-9  1
2000 Bonner GG, Davis P, Stropova D, Edsall S, Yamamura HI, Porreca F, Hruby VJ. Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays. Journal of Medicinal Chemistry. 43: 569-80. PMID 10691683 DOI: 10.1021/jm9900218  1
2000 Hosohata Y, Vanderah TW, Burkey TH, Ossipov MH, Kovelowski CJ, Sora I, Uhl GR, Zhang X, Rice KC, Roeske WR, Hruby VJ, Yamamura HI, Lai J, Porreca F. delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice. European Journal of Pharmacology. 388: 241-8. PMID 10675732 DOI: 10.1016/S0014-2999(99)00897-3  1
2000 Okura T, Cowell SM, Varga E, Burkey TH, Roeske WR, Hruby VJ, Yamamura HI. Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin. European Journal of Pharmacology. 387: R11-3. PMID 10650167 DOI: 10.1016/S0014-2999(99)00761-X  1
2000 Hohmann JG, Teal TH, Clifton DK, Davis J, Hruby VJ, Han G, Steiner RA. Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 278: R50-9. PMID 10644621  1
2000 Kriss CT, Lou BS, Szabò LZ, Mitchell SA, Hruby VJ, Polt R. Enkephalin-based drug design: Conformational analysis of O-linked glycopeptides by NMR and molecular modeling Tetrahedron Asymmetry. 11: 9-25. DOI: 10.1016/S0957-4166(99)00544-3  1
2000 Wang S, Tang X, Hruby VJ. First stereoselective synthesis of an optically pure β-substituted histidine: (2s,3s)-β-methylhistidine Tetrahedron Letters. 41: 1307-1310. DOI: 10.1016/S0040-4039(99)02223-6  1
1999 Hruby VJ, Agnes RS. Conformation-activity relationships of opioid peptides with selective activities at opioid receptors. Biopolymers. 51: 391-410. PMID 10797229 DOI: 10.1002/(SICI)1097-0282(1999)51:6<391::AID-BIP3>3.0.CO;2-X  1
1999 Alfaro-Lopez J, Okayama T, Hosohata K, Davis P, Porreca F, Yamamura HI, Hruby VJ. Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand. Journal of Medicinal Chemistry. 42: 5359-68. PMID 10639279 DOI: 10.1021/jm990337f  1
1999 Kovelowski CJ, Ossipov MH, Hruby VJ, Porreca F. Lesions of the dorsolateral funiculus block supraspinal opioid delta receptor mediated antinociception in the rat. Pain. 83: 115-22. PMID 10534582 DOI: 10.1016/S0304-3959(99)00083-4  1
1999 Kovelowski CJ, Bian D, Hruby VJ, Lai J, Ossipov MH, Porreca F. Selective opioid delta agonists elicit antinociceptive supraspinal/spinal synergy in the rat. Brain Research. 843: 12-7. PMID 10528105 DOI: 10.1016/S0006-8993(99)01803-X  0.92
1999 Hosohata K, Burkey TH, Alfaro-Lopez J, Hruby VJ, Roeske WR, Yamamura HI. (2S,3R)TMT-L-Tic-OH is a potent inverse agonist at the human delta-opioid receptor. European Journal of Pharmacology. 380: R9-10. PMID 10513562 DOI: 10.1016/S0014-2999(99)00516-6  1
1999 Lipkowski AW, Misicka A, Davis P, Stropova D, Janders J, Lachwa M, Porreca F, Yamamura HI, Hruby VJ. Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin. Bioorganic & Medicinal Chemistry Letters. 9: 2763-6. PMID 10509931 DOI: 10.1016/S0960-894X(99)00464-3  1
1999 Prabhu NV, Perkyns JS, Pettitt BM, Hruby VJ. Structure and dynamics of alpha-MSH using DRISM integral equation theory and stochastic dynamics. Biopolymers. 50: 255-72. PMID 10397788 DOI: 10.1002/(SICI)1097-0282(199909)50:3<255::AID-BIP3>3.0.CO;2-V  1
1999 Bartosz-Bechowski H, Davis P, Slaninova J, Malatynska E, Stropova D, Porreca F, Yamamura HI, Hruby VJ. Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 53: 329-36. PMID 10231722 DOI: 10.1034/j.1399-3011.1999.00033.x  1
1999 Hruby VJ. The Journal of Peptide Research: Editorial Journal of Peptide Research. 54: 175-176. DOI: 10.1034/j.1399-3011.1999.054003175.x  1
1999 Soloshonok VA, Cai C, Hruby VJ. Asymmetric Michael addition reactions of chiral Ni(II)-complex of glycine with (N-trans-enoyl)oxazolidines: Improved reactivity and stereochemical outcome Tetrahedron Asymmetry. 10: 4265-4269. DOI: 10.1016/S0957-4166(99)00483-8  1
1998 Huang QH, Hruby VJ, Tatro JB. Systemic α-MSH suppresses LPS fever via central melanocortin receptors independently of its suppression of corticosterone and IL-6 release. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 275: R524-R530. PMID 29592179 DOI: 10.1152/ajpregu.1998.275.2.R524  0.32
1998 Ni XP, Kesterson RA, Sharma SD, Hruby VJ, Cone RD, Wiedemann E, Humphreys MH. Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 274: R931-R938. PMID 29586884 DOI: 10.1152/ajpregu.1998.274.4.R931  0.72
1998 Li G, Haq W, Xiang L, Lou BS, Hughes R, De Leon IA, Davis P, Gillespie TJ, Romanowski M, Zhu X, Misicka A, Lipkowski AW, Porreca F, Davis TP, Yamamura HI, ... ... Hruby VJ, et al. Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide. Bioorganic & Medicinal Chemistry Letters. 8: 555-60. PMID 9871617 DOI: 10.1016/S0960-894X(98)00065-1  1
1998 Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI, Hruby VJ. De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor. Journal of Medicinal Chemistry. 41: 4767-76. PMID 9822547 DOI: 10.1021/jm980374r  1
1998 Sturm NS, Lin Y, Burley SK, Krstenansky JL, Ahn JM, Azizeh BY, Trivedi D, Hruby VJ. Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity. Journal of Medicinal Chemistry. 41: 2693-700. PMID 9667960 DOI: 10.1021/jm980084a  0.96
1998 Al-Obeidi F, O'Connor SD, Job C, Hruby VJ, Pettitt BM. NMR and quenched molecular dynamics studies of superpotent linear and cyclic alpha-melanotropins. The Journal of Peptide Research : Official Journal of the American Peptide Society. 51: 420-31. PMID 9650716 DOI: 10.1111/j.1399-3011.1998.tb00640.x  1
1998 Hosohata K, Burkey TH, Alfaro-Lopez J, Varga E, Hruby VJ, Roeske WR, Yamamura HI. Endomorphin-1 and endomorphin-2 are partial agonists at the human mu-opioid receptor. European Journal of Pharmacology. 346: 111-4. PMID 9617760 DOI: 10.1016/S0014-2999(98)00117-4  1
1998 Slaninova J, Appleyard SM, Misicka A, Lipkowski AW, Knapp RJ, Weber SJ, Davis TP, Yamamura HI, Hruby VJ. [125I-Tyr1]biphalin binding to opioid receptors of rat brain and NG108-15 cell membranes. Life Sciences. 62: PL199-204. PMID 9570343  1
1998 Uhrín D, Batta G, Hruby VJ, Barlow PN, Kövér KE. Sensitivity- and gradient-enhanced hetero (omega1) half-filtered TOCSY experiment for measuring long-range heteronuclear coupling constants. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 130: 155-61. PMID 9515088 DOI: 10.1006/JMRE.1997.1308  1
1998 Kövér KE, Uhrín D, Hruby VJ. Gradient- and Sensitivity-Enhanced TOCSY Experiments Journal of Magnetic Resonance. 130: 162-168. PMID 9500895 DOI: 10.1006/JMRE.1997.1309  1
1998 Hruby VJ. Chapter 16 Glucagon: Molecular biology and structure-activity Principles of Medical Biology. 10: 387-401. DOI: 10.1016/S1569-2582(97)80161-4  1
1998 Vanderah TW, Raffa RB, Lashbrook J, Burritt A, Hruby V, Porreca F. Orphanin-fq/nociceptin: Lack of antinociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats European Journal of Pain. 2: 267-280. DOI: 10.1016/S1090-3801(98)90023-4  1
1998 Lin J, Liao S, Hruby VJ. Asymmetric syntheses of highly hydrophobic chimeric aromatic amino acids: 2-Amino-3,3'-diarylpropionic acids Tetrahedron Letters. 39: 3117-3120. DOI: 10.1016/S0040-4039(98)00516-4  1
1998 Olczak J, Kaczmarek K, Maszczyńska I, Lisowski M, Stropova D, Hruby VJ, Yamamura HI, Lipkowski AW, Zabrocki J. Consequences of cis-amide bond simulation in opioid peptides International Journal of Peptide Research and Therapeutics. 5: 437-440.  1
1997 Hruby VJ, Ahn JM, Liao S. Synthesis of oligopeptide and peptidomimetic libraries. Current Opinion in Chemical Biology. 1: 114-9. PMID 9667835  1
1997 Kövér KE, Hruby VJ, Uhrín D. Sensitivity- and Gradient-Enhanced Heteronuclear Coupled/Decoupled HSQC-TOCSY Experiments for Measuring Long-Range Heteronuclear Coupling Constants Journal of Magnetic Resonance. 129: 125-129. PMID 9441876 DOI: 10.1006/JMRE.1997.1265  1
1997 Hruby VJ, Bartosz-Bechowski H, Davis P, Slaninova J, Zalewska T, Stropova D, Porreca F, Yamamura HI. Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors. Journal of Medicinal Chemistry. 40: 3957-62. PMID 9397176 DOI: 10.1021/jm9704762  1
1997 Romanowski M, Zhu X, Ramaswami V, Misicka A, Lipkowski AW, Hruby VJ, O'Brien DF. Interaction of a highly potent dimeric enkephalin analog, biphalin, with model membranes Biochimica Et Biophysica Acta - Biomembranes. 1329: 245-258. PMID 9371416 DOI: 10.1016/S0005-2736(97)00115-6  1
1997 Haaseth RC, Zalewska T, Davis P, Yamamura HI, Porreca F, Hruby VJ. Para-substituted phenylalanine-4 analogues of [L-Ala3]DPDPE: highly selective delta opioid receptor ligands. The Journal of Peptide Research : Official Journal of the American Peptide Society. 50: 171-7. PMID 9309580 DOI: 10.1111/J.1399-3011.1997.TB01182.X  1
1997 Abbruscato TJ, Thomas SA, Hruby VJ, Davis TP. Brain and spinal cord distribution of biphalin: correlation with opioid receptor density and mechanism of CNS entry. Journal of Neurochemistry. 69: 1236-45. PMID 9282948  0.48
1997 Hruby VJ, Li G, Haskell-Luevano C, Shenderovich M. Design of peptides, proteins, and peptidomimetics in chi space. Biopolymers. 43: 219-66. PMID 9277134 DOI: 10.1002/(SICI)1097-0282(1997)43:3<219::AID-BIP3>3.0.CO;2-Y  1
1997 Haskell-Luevano C, Toth K, Boteju L, Job C, Castrucci AM, Hadley ME, Hruby VJ. beta-Methylation of the Phe7 and Trp9 melanotropin side chain pharmacophores affects ligand-receptor interactions and prolonged biological activity. Journal of Medicinal Chemistry. 40: 2740-9. PMID 9276019 DOI: 10.1021/jm970018t  1
1997 Misicka A, Cavagnero S, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Synthesis and biological properties of beta-MePhe3 analogues of deltorphin I and dermenkephalin: influence of biased chi 1 Phe3 residues on peptide recognition for delta-opioid receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 50: 48-54. PMID 9273887 DOI: 10.1111/J.1399-3011.1997.TB00619.X  1
1997 Azizeh BY, Ahn JM, Caspari R, Shenderovich MD, Trivedi D, Hruby VJ. The role of phenylalanine at position 6 in glucagon's mechanism of biological action: multiple replacement analogues of glucagon. Journal of Medicinal Chemistry. 40: 2555-62. PMID 9258362 DOI: 10.1021/jm960800d  0.96
1997 Kramer TH, Bartosz-Bechowski H, Davis P, Hruby VJ, Porreca F. Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy. Life Sciences. 61: 129-35. PMID 9217271 DOI: 10.1016/S0024-3205(97)00367-6  1
1997 Haskell-Luevano C, Hendrata S, North C, Sawyer TK, Hadley ME, Hruby VJ, Dickinson C, Gantz I. Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R. Journal of Medicinal Chemistry. 40: 2133-9. PMID 9216831 DOI: 10.1021/jm960840h  1
1997 Quock RM, Hosohata Y, Knapp RJ, Burkey TH, Hosohata K, Zhang X, Rice KC, Nagase H, Hruby VJ, Porreca F, Roeske WR, Yamamura HI. Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor. European Journal of Pharmacology. 326: 101-4. PMID 9178661 DOI: 10.1016/S0014-2999(97)83488-7  1
1997 Patel D, McKinley BD, Davis TP, Porreca F, Yamamura HI, Hruby VJ. Peptide targeting and delivery across the blood-brain barrier utilizing synthetic triglyceride esters: design, synthesis, and bioactivity. Bioconjugate Chemistry. 8: 434-41. PMID 9177851 DOI: 10.1021/bc970027g  1
1997 Haskell-Luevano C, Nikiforovich G, Sharma SD, Yang YK, Dickinson C, Hruby VJ, Gantz I. Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors. Journal of Medicinal Chemistry. 40: 1738-48. PMID 9171884 DOI: 10.1021/jm960845e  1
1997 Bonner GG, Davis P, Stropova D, Ferguson R, Yamamura HI, Porreca F, Hruby VJ. Opioid peptides: simultaneous delta agonism and mu antagonism in somatostatin analogues. Peptides. 18: 93-100. PMID 9114458 DOI: 10.1016/S0196-9781(96)00242-2  1
1997 Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4. Life Sciences. 60: 1263-9. PMID 9096243 DOI: 10.1016/S0024-3205(97)00069-6  1
1997 Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 385: 165-8. PMID 8990120 DOI: 10.1038/385165a0  1
1997 Shenderovich MD, Kövér KE, Wilke S, Collins N, Hruby VJ. Solution conformations of potent bicyclic antagonists of oxytocin by nuclear magnetic resonance spectroscopy and molecular dynamics simulations Journal of the American Chemical Society. 119: 5833-5846. DOI: 10.1021/ja963736y  1
1997 Han Y, Hruby VJ. Lewis acid promoted conjugate addition of vinylmagnesium bromide to chiral α,β-unsaturated N-acyl oxazolidinones Tetrahedron Letters. 38: 7317-7320. DOI: 10.1016/S0040-4039(97)01777-2  1
1997 Yuan W, Hruby VJ. Asymmetric synthesis of unusual amino acid: Synthesis of four isomers of β-methyl-3-(2'-naphthyl)alanine Tetrahedron Letters. 38: 3853-3856. DOI: 10.1016/S0040-4039(97)00770-3  1
1996 Bilsky EJ, Inturrisi CE, Sadée W, Hruby VJ, Porreca F. Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective μ or δ opioid agonists in mice Pain. 68: 229-237. PMID 9121809 DOI: 10.1016/S0304-3959(96)03185-5  1
1996 Haskell-Luevano C, Sawyer TK, Trumpp-Kallmeyer S, Bikker JA, Humblet C, Gantz I, Hruby VJ. Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists. Drug Design and Discovery. 14: 197-211. PMID 9017363  1
1996 Hadley ME, Hruby VJ, Jiang J, Sharma SD, Fink JL, Haskell-Luevano C, Bentley DL, al-Obeidi F, Sawyer TK. Melanocortin receptors: identification and characterization by melanotropic peptide agonists and antagonists. Pigment Cell Research / Sponsored by the European Society For Pigment Cell Research and the International Pigment Cell Society. 9: 213-34. PMID 9014208  1
1996 Haskell-Luevano C, Sawyer TK, Hendrata S, North C, Panahinia L, Stum M, Staples DJ, Castrucci AM, Hadley MF, Hruby VJ. Truncation studies of alpha-melanotropin peptides identify tripeptide analogues exhibiting prolonged agonist bioactivity. Peptides. 17: 995-1002. PMID 8899819 DOI: 10.1016/S0196-9781(96)00141-6  1
1996 Qian X, Liao S, Stropova D, Yamamura HI, Hruby VJ. Novel scaffolds for non-peptide mimetics of delta opioid receptor agonists based on peptide leads. Regulatory Peptides. 65: 79-82. PMID 8876039 DOI: 10.1016/0167-0115(96)00075-4  1
1996 Ramaswami V, Zhu X, Romanowski M, Haaseth RC, Misicka A, Lipkowski AW, Hruby VJ, O'Brien DF. Lipid membrane permeability of modified c[D-Pen2, D-Pen5]enkephalin peptides International Journal of Peptide and Protein Research. 48: 87-94. PMID 8844267 DOI: 10.1111/J.1399-3011.1996.TB01110.X  1
1996 Boteju LW, Nikiforovich GV, Haskell-Luevano C, Fang SN, Zalewska T, Stropova D, Yamamura HI, Hruby VJ. The use of topographical constraints in receptor mapping: investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp-(N-Me)Nle-Asp-Phe-NH2 (SNF 9007), a cholecystokinin (26-33) analogue that binds to both CCK-B and delta-opioid receptors. Journal of Medicinal Chemistry. 39: 4120-4. PMID 8831778 DOI: 10.1021/jm960078j  1
1996 Misicka A, Maszczynska I, Lipkowski AW, Stropova D, Yamamura HI, Hruby VJ. Synthesis and biological properties of gamma-glutamyl-dermorphin, a prodrug. Life Sciences. 58: 905-11. PMID 8786696 DOI: 10.1016/0024-3205(96)00033-1  1
1996 Williams SA, Abbruscato TJ, Hruby VJ, Davis TP. Passage of a delta-opioid receptor selective enkephalin, [D-penicillamine2,5] enkephalin, across the blood-brain and the blood-cerebrospinal fluid barriers. Journal of Neurochemistry. 66: 1289-99. PMID 8769896 DOI: 10.1046/j.1471-4159.1996.66031289.x  0.48
1996 Van Tine BA, Azizeh BY, Trivedi D, Phelps JR, Houslay MD, Johnson DG, Hruby VJ. Low level cyclic adenosine 3',5'-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists. Endocrinology. 137: 3316-22. PMID 8754757 DOI: 10.1210/endo.137.8.8754757  1
1996 Roerig SC, Williams CL, Hruby VJ, Burks TF, Rosenfeld GC. Inhibition of adenylyl cyclase activity by the cholecystokinin analog SNF 9007 in neuroblastoma x glioma NG108-15 hybrid cells. Regulatory Peptides. 61: 51-6. PMID 8701027 DOI: 10.1016/0167-0115(95)00137-9  1
1996 Lung FD, Meyer JP, Lou BS, Xiang L, Li G, Davis P, DeLeon IA, Yamamura HI, Porreca F, Hruby VJ. Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency. Journal of Medicinal Chemistry. 39: 2456-60. PMID 8691442 DOI: 10.1021/jm950655o  1
1996 Lung FD, Collins N, Stropova D, Davis P, Yamamura HI, Porreca F, Hruby VJ. Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2. Journal of Medicinal Chemistry. 39: 1136-41. PMID 8676350 DOI: 10.1021/jm950369c  1
1996 Ossipov MH, Kovelowski CJ, Nichols ML, Hruby VJ, Porreca F. Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat. Pain. 62: 287-93. PMID 8657428 DOI: 10.1016/0304-3959(94)00231-3  0.36
1996 Haskell-Luevano C, Miwa H, Dickinson C, Hadley ME, Hruby VJ, Yamada T, Gantz I. Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R. Journal of Medicinal Chemistry. 39: 432-5. PMID 8558511 DOI: 10.1021/jm950407s  1
1996 Qian X, Shenderovich MD, Kover KE, Davis P, Horvath R, Zalewska T, Yamamura HI, Porreca F, Hruby VJ. Probing the stereochemical requirements for receptor recognition of δ opioid agonists through topographic modifications in position 1 Journal of the American Chemical Society. 118: 7280-7290. DOI: 10.1021/ja954241w  1
1996 Liao S, Hruby VJ. Asymmetric synthesis of optically pure β-isopropylphenylalanine: A new β-branched unusual amino acid Tetrahedron Letters. 37: 1563-1566. DOI: 10.1016/0040-4039(96)00091-3  1
1995 Davis TP, Abbruscato TJ, Brownson E, Hruby VJ. Conformationally constrained peptide drugs targeted at the blood-brain barrier. Nida Research Monograph. 154: 47-60. PMID 8606749  0.48
1995 Knapp RJ, Landsman R, Waite S, Malatynska E, Varga E, Haq W, Hruby VJ, Roeske WR, Nagase H, Yamamura HI. Properties of TAN-67, a nonpeptidic delta-opioid receptor agonist, at cloned human delta- and mu-opioid receptors. European Journal of Pharmacology. 291: 129-34. PMID 8566162 DOI: 10.1016/0922-4106(95)90134-5  1
1995 Meyer JP, Gillespie TJ, Hom S, Hruby VJ, Davis TP. In vitro stability of some reduced peptide bond pseudopeptide analogues of dynorphin A. Peptides. 16: 1215-9. PMID 8545241 DOI: 10.1016/0196-9781(95)02005-H  0.72
1995 Hruby VJ, Danho W, Yamashiro D. Johannes Arnold Meienhofer. 1929-1993 International Journal of Peptide and Protein Research. 46: 193-194. PMID 8537169 DOI: 10.1111/J.1399-3011.1995.TB00587.X  1
1995 Lung FD, Meyer JP, Li G, Lou BS, Stropova D, Davis P, Yamamura HI, Porreca F, Hruby VJ. Highly kappa receptor-selective dynorphin A analogues with modifications in position 3 of dynorphin A(1-11)-NH2. Journal of Medicinal Chemistry. 38: 585-6. PMID 7861405 DOI: 10.1021/JM00004A002  1
1995 Haskell-Luevano C, Shenderovich MD, Sharma SD, Nikiforovich GV, Hadley ME, Hruby VJ. Design, synthesis, biology, and conformations of bicyclic alpha-melanotropin analogues. Journal of Medicinal Chemistry. 38: 1736-50. PMID 7752197  1
1995 Knapp RJ, Malatynska E, Collins N, Fang L, Wang JY, Hruby VJ, Roeske WR, Yamamura HI. Molecular biology and pharmacology of cloned opioid receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 9: 516-25. PMID 7737460  1
1995 Meyer JP, Davis P, Lee KB, Porreca F, Yamamura HI, Hruby VJ. Synthesis using a Fmoc-based strategy and biological activities of some reduced peptide bond pseudopeptide analogues of dynorphin A1. Journal of Medicinal Chemistry. 38: 3462-8. PMID 7658433 DOI: 10.1021/JM00018A006  1
1995 Hruby VJ, Lu D, Sharma SD, Castrucci AL, Kesterson RA, al-Obeidi FA, Hadley ME, Cone RD. Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. Journal of Medicinal Chemistry. 38: 3454-61. PMID 7658432 DOI: 10.1021/JM00018A005  1
1995 Hruby VJ, Yamamura HI, Porreca F. Molecular organization of receptors. Efficacy, agonists, and antagonists. Annals of the New York Academy of Sciences. 757: 7-22. PMID 7611710 DOI: 10.1111/j.1749-6632.1995.tb17461.x  1
1995 Misicka A, Lipkowski AW, Slaninova J, Davis P, Yamamura HI, Porreca F, Hruby VJ. The synthesis and opioid receptor binding affinities of analogues of dermorphin and its N-terminal tetrapeptide fragment with dibasic acids in position 2. Life Sciences. 57: 1633-40. PMID 7475903 DOI: 10.1016/0024-3205(95)02142-6  1
1995 Haskell-Luevano C, Boteju LW, Miwa H, Dickinson C, Gantz I, Yamada T, Hadley ME, Hruby VJ. Topographical modification of melanotropin peptide analogues with beta-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities. Journal of Medicinal Chemistry. 38: 4720-9. PMID 7473600  1
1995 Lung FD, Li G, Lou BS, Hruby VJ. A new strategy for the synthesis of four individual isomers of β-methylphenylalanine Synthetic Communications. 25: 57-61. DOI: 10.1080/00397919508010789  1
1995 Azizeh BY, Van Tine BA, Sturm NS, Hutzler AM, David C, Trivedi D, Hruby VJ. [des His1, des Phe6, Glu9]glucagon amide: A newly designed "pure" glucagon antagonist Bioorganic and Medicinal Chemistry Letters. 5: 1849-1852. DOI: 10.1016/0960-894X(95)00307-F  1
1995 Xiang L, Wu H, Hruby VJ. Stereoselective synthesis of all individual isomers of β-methyl-2′,6′-dimethylphenylalanine Tetrahedron: Asymmetry. 6: 83-86. DOI: 10.1016/0957-4166(94)00357-H  1
1995 Qian X, Russell KC, Boteju LW, Hruby VJ. Stereoselective total synthesis of topographically constrained designer amino acids: 2′, 6′-dimethyl-β-methyltyrosines Tetrahedron. 51: 1033-1054. DOI: 10.1016/0040-4020(94)00996-8  1
1995 Misicka A, Lipkowski AW, Stropova D, Davis P, Porreca F, Yamamura HI, Hruby VJ. Amino acids with amphiphilic side chains: Deltorphin analogues with Phe3 replaced by all β-hydroxyphenylalanine diastereoisomers Letters in Peptide Science. 2: 203-205. DOI: 10.1007/BF00119153  1
1995 Lipkowski AW, Misicka A, Porreca F, Davis P, Yamamura HI, Stropova D, Hruby VJ. Benzomorphan alkaloids: Natural peptidomimetics of opioid peptide pharmacophores Letters in Peptide Science. 2: 177-181. DOI: 10.1007/BF00119147  1
1995 Haskell-Luevano C, Boteju LW, Hruby VJ. Facile removal of the N-indole-mesitylenesulfonyl protecting group using HF cleavage conditions Letters in Peptide Science. 1: 163-170. DOI: 10.1007/BF00117952  1
1994 Bartosz-Bechowski H, Davis P, Zalewska T, Slaninova J, Porreca F, Yamamura HI, Hruby VJ. Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors. Journal of Medicinal Chemistry. 37: 146-50. PMID 8289188 DOI: 10.1021/JM00027A018  1
1994 Misicka A, Lipkowski AW, Horvath R, Davis P, Yamamura HI, Porreca F, Hruby VJ. Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors. Journal of Medicinal Chemistry. 37: 141-5. PMID 8289187 DOI: 10.1021/JM00027A017  1
1994 Knapp RJ, Malatynska E, Fang L, Li X, Babin E, Nguyen M, Santoro G, Varga EV, Hruby VJ, Roeske WR. Identification of a human delta opioid receptor: cloning and expression. Life Sciences. 54: PL463-9. PMID 8201839 DOI: 10.1016/0024-3205(94)90138-4  1
1994 Knapp RJ, Malatynska E, Hashimoto S, Fang S, Hunt M, Wamsley JK, Peterson P, Zalewska T, Hruby VJ, Yamamura HI. [3H]SNF8702 autoradiography of CCK-B receptors in guinea pig brain and studies with a cloned rat CCK-B receptor. Annals of the New York Academy of Sciences. 713: 380-3. PMID 8185194 DOI: 10.1111/j.1749-6632.1994.tb44099.x  1
1994 Vanderah T, Takemori AE, Sultana M, Portoghese PS, Mosberg HI, Hruby VJ, Haaseth RC, Matsunaga TO, Porreca F. Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo. European Journal of Pharmacology. 252: 133-7. PMID 8157053 DOI: 10.1016/0014-2999(94)90588-6  1
1994 Polt R, Porreca F, Szabò LZ, Bilsky EJ, Davis P, Abbruscato TJ, Davis TP, Harvath R, Yamamura HI, Hruby VJ. Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America. 91: 7114-8. PMID 8041755 DOI: 10.1073/pnas.91.15.7114  1
1994 Bilsky EJ, Bernstein RN, Pasternak GW, Hruby VJ, Patel D, Porreca F, Lai J. Selective inhibition of [D-ALA2, GLU4]deltrophin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor Life Sciences. 55: PL37-PL43. PMID 8015351 DOI: 10.1016/0024-3205(94)90110-4  1
1994 Haskell-Luevano C, Miwa H, Dickinson C, Hruby VJ, Yamada T, Gantz I. Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R. Biochemical and Biophysical Research Communications. 204: 1137-42. PMID 7980588  0.72
1994 Meyer JP, Collins N, Lung FD, Davis P, Zalewska T, Porreca F, Yamamura HI, Hruby VJ. Design, synthesis, and biological properties of highly potent cyclic dynorphin A analogues. Analogues cyclized between positions 5 and 11. Journal of Medicinal Chemistry. 37: 3910-7. PMID 7966152 DOI: 10.1021/JM00049A010  1
1994 Collins N, Hruby VJ. Prediction of the conformational requirements for binding to the κ‐opioid receptor and its subtypes. I. Novel α‐helical cyclic peptides and their role in receptor selectivity Biopolymers. 34: 1231-1241. PMID 7948735 DOI: 10.1002/bip.360340911  1
1994 Hruby VJ, Qian X. Approaches to the asymmetric synthesis of unusual amino acids Methods in Molecular Biology (Clifton, N.J.). 35: 249-286. PMID 7894604 DOI: 10.1385/0-89603-273-6:249  1
1994 Hruby VJ, Bonner GG. Design of novel synthetic peptides including cyclic conformationally and topographically constrained analogs Methods in Molecular Biology (Clifton, N.J.). 35: 201-240. PMID 7894602 DOI: 10.1385/0-89603-273-6:201  1
1994 Knapp RJ, Malatynska E, Peterson P, Zalewska T, Fang S, Hruby VJ, Smith TL, Yamamura HI. [N-methylnorleucine-(28,31)]cholecystokinin-(26-33) (SNF 8702) activity at a cloned rat CCKB receptor. European Journal of Pharmacology. 269: 133-8. PMID 7851490 DOI: 10.1016/0922-4106(94)90079-5  1
1994 Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Delta opioid receptor selective ligands; DPLPE-deltorphin chimeric peptide analogues. International Journal of Peptide and Protein Research. 44: 80-4. PMID 7718035 DOI: 10.1111/J.1399-3011.1994.TB00407.X  1
1994 Rao RK, Levenson S, Fang SN, Hruby VJ, Yamamura HI, Porreca F. Role of substance P in the regulation of ion transport by CCKA and CCKB receptors in mouse ileum. Annals of the New York Academy of Sciences. 713: 420-1. PMID 7514373 DOI: 10.1111/j.1749-6632.1994.tb44113.x  1
1994 Roerig SC, Williams CL, Hruby VJ, Burks TF, Rosenfeld GC. Cholecystokinin (CCK) analog SNF9007-induced inhibition of adenylyl cyclase activity in NG108-16 hybrid cells and SH-SY5Y cells shows differential activation of d opioid receptors Regulatory Peptides. 54: 247-248. DOI: 10.1016/0167-0115(94)90482-0  1
1994 Hruby VJ, Collins N, Lung FD, Meyer JP, Davis TP, Yamamura HI, Porreca F. Design of peptides and peptidomimetics for delta and kappa opioid receptor subtypes Regulatory Peptides. 54: 123-124. DOI: 10.1016/0167-0115(94)90420-0  1
1994 Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Structure-activity relationships of analogues of higly potent opioid peptide, biphalin Regulatory Peptides. 53: S131-S132. DOI: 10.1016/0167-0115(94)90276-3  1
1994 Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Topographic model of delta opioid selective ligands; DPLPE-deltorphin hybrid analogues Regulatory Peptides. 53: S129-S130. DOI: 10.1016/0167-0115(94)90275-5  1
1994 Hruby VJ, Misicka A, Lipkowski AW, Haaseth R, Bartosz H, Qian X, Collins N, Meyer JP, Szabo L, Polt R, Porreca F, Davis T, Yamamura HI. New opioid compounds in analgesia Regulatory Peptides. 53: S71-S72. DOI: 10.1016/0167-0115(94)90246-1  1
1994 Li G, Patel D, Hruby VJ. 1, 2-Asymmetric cis induction and its application to the asymmetric synthesis of precursors of β-branched unusual amino acids Tetrahedron Letters. 35: 2301-2304. DOI: 10.1016/0040-4039(94)85204-9  1
1993 Wild KD, Horan PJ, Misicka A, Lipkowski A, Haaseth RC, Matsunaga TO, Hruby VJ, Toth G, Borsodi A, Yamamura HI. Pseudoirreversible binding characteristics of [D-Ala2,Glu4]deltorphin and its Cys4 substituted derivative to delta-opioid receptors. European Journal of Pharmacology. 246: 25-31. PMID 8394818 DOI: 10.1016/0922-4106(93)90005-T  1
1993 Miller CL, Hruby VJ, Matsunaga TO, Bickford PC. Alpha-MSH and MCH are functional antagonists in a CNS auditory gating paradigm. Peptides. 14: 431-40. PMID 8392716 DOI: 10.1016/0196-9781(93)90128-4  1
1993 Sawyer TK, Castrucci AM, Staples DJ, Affholter JA, De Vaux A, Hruby VJ, Hadley ME. Structure-activity relationships of [Nle4, D-Phe7]alpha-MSH. Discovery of a tripeptidyl agonist exhibiting sustained bioactivity. Annals of the New York Academy of Sciences. 680: 597-9. PMID 8390200 DOI: 10.1111/J.1749-6632.1993.TB19749.X  0.64
1993 Miller CL, Hruby VJ, Matsunaga TO, Bickford PC. alpha-MSH and MCH are functional antagonists in a central nervous system auditory gating paradigm. Annals of the New York Academy of Sciences. 680: 571-4. PMID 8390195 DOI: 10.1111/j.1749-6632.1993.tb19742.x  1
1993 Horan PJ, Wild KD, Kazmierski WM, Ferguson R, Hruby VJ, Weber SJ, Davis TP, Fang L, Knapp RJ, Yamamura HI. Unexpected antinociceptive potency of cyclic [D-Tca1]CTAP: potential for a novel mechanism of action. European Journal of Pharmacology. 233: 53-62. PMID 8386089 DOI: 10.1016/0014-2999(93)90348-L  1
1993 Nikiforovich GV, Hruby VJ. Models for the A- and B-Receptor-Bound Conformations of CCK-8 Biochemical and Biophysical Research Communications. 194: 9-16. PMID 8333874 DOI: 10.1006/bbrc.1993.1777  1
1993 Matsunaga TO, Collins N, Ramaswami V, Yamamura SH, O'Brien DF, Hruby VJ. Comparison of the membrane-bound states of two structurally similar delta-selective opioid peptides by transferred nuclear Overhauser effect spectroscopy and molecular modeling. Biochemistry. 32: 13180-9. PMID 8241172 DOI: 10.1021/BI00211A029  0.6
1993 Ito AS, Castrucci AMDL, Hruby VJ, Hadley ME, Krajcarski DT, Szabo AG. Structure-activity correlations of melanotropin peptides in model lipids by tryptophan fluorescence studies Biochemistry. 32: 12264-12272. PMID 8218305  1
1993 Hruby VJ. Conformational and topographical considerations in the design of biologically active peptides Biopolymers. 33: 1073-1082. PMID 8102072 DOI: 10.1002/BIP.360330709  1
1993 Kawasaki AM, Knapp RJ, Kramer TH, Walton A, Wire WS, Hashimoto S, Yamamura HI, Porreca F, Burks TF, Hruby VJ. Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs. Journal of Medicinal Chemistry. 36: 750-7. PMID 8096246 DOI: 10.1021/JM00058A012  1
1993 Kawasaki AM, Knapp RJ, Walton A, Wire WS, Zalewska T, Yamamura HI, Porreca F, Burks TF, Hruby VJ. Syntheses, opioid binding affinities, and potencies of dynorphin A analogues substituted in positions, 1, 6, 7, 8 and 10. International Journal of Peptide and Protein Research. 42: 411-9. PMID 7906258 DOI: 10.1111/J.1399-3011.1993.TB00148.X  1
1993 Boteju LW, Zalewska T, Yamamura HI, Hruby VJ. Tryptophan-norleucine 1,5-disubstituted tetrazoles as cis peptide bond mimics: Investigation of the bioactive conformation of a potent and selective peptide for the cholecystokinin-B receptor Bioorganic and Medicinal Chemistry Letters. 3: 2011-2016. DOI: 10.1016/S0960-894X(01)81005-2  1
1993 Hristova-Kazmierski MK, Horan P, Davis P, Yamamura HI, Kramer T, Horvath R, Kazmierski WM, Porreca F, Hruby VJ. A new approach to enhance bioavailability of biologically active peptides: conjugation of a δ opioid agonist to β-cyclodextrin Bioorganic and Medicinal Chemistry Letters. 3: 831-834. DOI: 10.1016/S0960-894X(00)80675-7  1
1993 Li G, Pattel D, Hruby VJ. Asymmetric synthesis of (2R, 3S) and (2S, 3R) precursors of β-methyl-histidine, -phenylalanine and -tyrosine Tetrahedron: Asymmetry. 4: 2315-2318. DOI: 10.1016/S0957-4166(00)80091-9  1
1993 Li G, Russell KC, Jarosinski MA, Hruby VJ. Asymmetric synthesis of unusual amino acids : An enantioselective synthesis of the four isomers of D- and L-O-Methyl-2′, β-Dimethyltyrosine Tetrahedron Letters. 34: 2565-2568. DOI: 10.1016/S0040-4039(00)77626-X  1
1993 Li G, Jarosinski MA, Hruby VJ. Diastereospecific tandem Michael-like addition / electrophilic bromination: A one-pot tandem asymmetric synthesis of precursors of unusual amino acids Tetrahedron Letters. 34: 2561-2564. DOI: 10.1016/S0040-4039(00)77625-8  1
1993 Li G, Patel D, Hruby VJ. An efficient procedure for the demethylation of aryl-methyl ethers in optically pure unusual amino acids Tetrahedron Letters. 34: 5393-5396. DOI: 10.1016/S0040-4039(00)73917-7  1
1993 Boteju LW, Hruby VJ. Tryptophan-containing 1,5-tetrazole dipeptide analogs: Synthesis of Trpψ[CN4]Nle as a cis amide bond surrogate Tetrahedron Letters. 34: 1757-1760. DOI: 10.1016/S0040-4039(00)60771-2  1
1993 Jiao D, Russell KC, Hruby VJ. Locally constrained tyrosine analogues with restricted side chain dynamics Tetrahedron. 49: 3511-3520. DOI: 10.1016/S0040-4020(01)90211-X  1
1993 Kover KE, Prakash O, Hruby VJ. z-Filtered Heteronuclear Coupled-HSQC-TOCSY Experiment as a Means for Measuring Long-Range Heteronuclear Coupling Constants Journal of Magnetic Resonance, Series A. 103: 92-96. DOI: 10.1006/jmra.1993.1136  1
1992 Smith DD, Slaninova J, Hruby VJ. Structure-activity studies of a novel bicyclic oxytocin antagonist. Journal of Medicinal Chemistry. 35: 1558-63. PMID 1578481 DOI: 10.1021/JM00087A009  1
1992 Ramaswami V, Haaseth RC, Matsunaga TO, Hruby VJ, O'Brien DF. Opioid peptide interactions with lipid bilayer membranes. Biochimica Et Biophysica Acta. 1109: 195-202. PMID 1520696 DOI: 10.1016/0005-2736(92)90083-X  0.48
1992 Lebl M, Toth G, Slaninova J, Hruby VJ. Conformationally biased analogs of oxytocin International Journal of Peptide and Protein Research. 40: 148-151. PMID 1446971 DOI: 10.1111/J.1399-3011.1992.TB01463.X  1
1992 Dharanipragada R, Bruck M, Hruby VJ. The absolute configuration of an intermediate in the asymmetric synthesis of unusual amino acids Acta Crystallographica, Section C: Crystal Structure Communications. 48. PMID 1418812 DOI: 10.1107/S0108270191013884  1
1992 Hruby VJ. Strategies in the development of peptide antagonists Progress in Brain Research. 92: 215-224. PMID 1363847 DOI: 10.1016/S0079-6123(08)61177-2  1
1992 Kazmierski WM, Ferguson RD, Knapp RJ, Lui GK, Yamamura HI, Hruby VJ. Reduced peptide bond cyclic somatostatin based opioid octapeptides. Synthesis, conformational properties and pharmacological characterization. International Journal of Peptide and Protein Research. 39: 401-14. PMID 1358847  1
1992 Fang L, Knapp RJ, Matsunaga T, Weber SJ, Davis T, Hruby VJ, Yamamura HI. Synthesis of [D-Ala2,4'-125I-Phe3,Glu4]deltorphin and characterization of its delta opioid receptor binding properties. Life Sciences. 51: PL189-93. PMID 1331636 DOI: 10.1016/0024-3205(92)90628-3  1
1992 Misicka A, Lipkowski AW, Horvath R, Davis P, Kramer TH, Yamamura HI, Hruby VJ. Topographical requirements for delta opioid ligands: common structural features of dermenkephalin and deltorphin. Life Sciences. 51: 1025-32. PMID 1326067 DOI: 10.1016/0024-3205(92)90501-F  1
1992 Toth G, Russell KC, Landis G, Kramer TH, Fang L, Knapp R, Davis P, Burks TF, Yamamura HI, Hruby VJ. Ring substituted and other conformationally constrained tyrosine analogues of [D-Pen2,D-Pen5]enkephalin with delta opioid receptor selectivity. Journal of Medicinal Chemistry. 35: 2384-91. PMID 1320122  1
1992 Horan P, Tallarida RJ, Haaseth RC, Matsunaga TO, Hruby VJ, Porreca F. Antinociceptive interactions of opioid delta receptor agonists with morphine in mice: supra- and sub-additivity. Life Sciences. 50: 1535-41. PMID 1315897 DOI: 10.1016/0024-3205(92)90144-E  0.32
1992 Yamamura MS, Horvath R, Toth G, Otvos F, Malatynska E, Knapp RJ, Porreca F, Hruby VJ, Yamamura HI. Characterization of [3H]naltrindole binding to delta opioid receptors in rat brain. Life Sciences. 50: PL119-24. PMID 1313133 DOI: 10.1016/0024-3205(92)90464-Z  1
1992 Búzás B, Tóth G, Cavagnero S, Hruby VJ, Borsodi A. Synthesis and binding characteristics of the highly delta-specific new tritiated opioid peptide, [3H]deltorphin II. Life Sciences. 50: PL75-8. PMID 1313131 DOI: 10.1016/0024-3205(92)90103-V  1
1992 Misicka A, Nikiforovich G, Lipkowski AW, Horvath R, Davis P, Kramer TH, Yamamura HI, Hruby VJ. Topographical requirements for delta opioid ligands: The synthesis and biological properties of a cyclic analogue of deltorphin I Bioorganic and Medicinal Chemistry Letters. 2: 547-552. DOI: 10.1016/S0960-894X(01)81195-1  1
1992 Boteju LW, Wegner K, Hruby VJ. Asymmetric synthesis of unusual amino acids: Synthesis of the optically pure isomers of indole-protected β-methyltryptophan suitable for peptide synthesis Tetrahedron Letters. 33: 7491-7494. DOI: 10.1016/S0040-4039(00)60804-3  1
1992 Kövér KE, Prakash O, Hruby VJ. Efficient purging sequence for 1H-detected heteronuclear shift correlation experiments Journal of Magnetic Resonance (1969). 99: 426-432. DOI: 10.1016/0022-2364(92)90198-G  1
1991 Lam KS, Salmon SE, Hersh EM, Hruby VJ, Kazmierski WM, Knapp RJ. A new type of synthetic peptide library for identifying ligand-binding activity. Nature. 354: 82-4. PMID 1944576 DOI: 10.1038/354082a0  0.56
1991 Kramer TH, Toth G, Haaseth RC, Matsunaga TO, Davis P, Hruby VJ, Burks TF. Influence of peptidase inhibitors on the apparent agonist potency of delta selective opioid peptides in vitro. Life Sciences. 48: 881-6. PMID 1847736 DOI: 10.1016/0024-3205(91)90034-9  1
1991 Lebl M, Fang S, Hruby VJ. High-performance liquid chromatography of peptides at reduced temperatures: Separation of isomers Journal of Chromatography A. 586: 145-148. PMID 1806549 DOI: 10.1016/0021-9673(91)80032-C  1
1991 Nikiforovich GV, Hruby VJ, Prakash O, Gehrig CA. Topographical requirements for δ-selective opioid peptides Biopolymers. 31: 941-955. PMID 1782355 DOI: 10.1002/BIP.360310804  1
1991 Pettitt BM, Matsunaga T, al-Obeidi F, Gehrig C, Hruby VJ, Karplus M. Dynamical search for bis-penicillamine enkephalin conformations. Biophysical Journal. 60: 1540-4. PMID 1777571 DOI: 10.1016/S0006-3495(91)82188-9  0.6
1991 Zechel C, Trivedi D, Hruby VJ. Synthetic glucagon antagonists and partial agonists International Journal of Peptide and Protein Research. 38: 131-138. PMID 1664420 DOI: 10.1111/J.1399-3011.1991.TB01420.X  1
1991 Slaninova J, Knapp RJ, Wu JJ, Fang SN, Kramer T, Burks TF, Hruby VJ, Yamamura HI. Opioid receptor binding properties of analgesic analogues of cholecystokinin octapeptide. European Journal of Pharmacology. 200: 195-8. PMID 1663041 DOI: 10.1016/0014-2999(91)90688-M  1
1991 Chan WY, Berezin I, Daniel EE, Russell KC, Hruby VJ. Effects of inactivation of oxytocin receptor and inhibition of prostaglandin synthesis on uterine oxytocin receptor and gap junction formation and labor in the rat. Canadian Journal of Physiology and Pharmacology. 69: 1262-7. PMID 1661637 DOI: 10.1139/Y91-185  1
1991 Misicka A, Lipkowski AW, Fang L, Knapp RJ, Davis P, Kramer T, Burks TF, Yamamura HI, Carr DB, Hruby VJ. Topographical requirements for delta opioid ligands: presence of a carboxyl group in position 4 is not critical for deltorphin high delta receptor affinity and analgesic activity. Biochemical and Biophysical Research Communications. 180: 1290-7. PMID 1659410 DOI: 10.1016/S0006-291X(05)81335-X  1
1991 Cavagnero S, Misicka A, Knapp RJ, Davis P, Fang L, Burks TF, Yamamura HI, Hruby VJ. Delta opioid receptor-selective ligands: [D-Pen2,D-Pen5]enkephalin-dermenkephalin chimeric peptides. Life Sciences. 49: 495-503. PMID 1650414 DOI: 10.1016/0024-3205(91)90066-K  1
1991 Hruby VJ, Toth G, Gehrig CA, Kao LF, Knapp R, Lui GK, Yamamura HI, Kramer TH, Davis P, Burks TF. Topographically designed analogues of [D-Pen,D-Pen5]enkephalin. Journal of Medicinal Chemistry. 34: 1823-30. PMID 1648137  1
1991 Olson BR, Drutarosky MD, Chow MS, Hruby VJ, Stricker EM, Verbalis JG. Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats. Peptides. 12: 113-8. PMID 1646995 DOI: 10.1016/0196-9781(91)90176-P  1
1991 Hruby VJ, Sharma SD. Designing peptide and protein ligands for biological receptors Current Opinion in Biotechnology. 2: 599-605. PMID 1369346 DOI: 10.1016/0958-1669(91)90086-K  1
1991 Dharanipragada R, Alarcon A, Hruby VJ. A convenient synthesis of (2S)-2-Amino-3-phenylpropanol Organic Preparations and Procedures International. 23: 396-397. DOI: 10.1080/00304949109458222  1
1991 Kazmierski WM, Hruby VJ. Asymmetric synthesis of topographically constrained amino acids: synthesis of the optically pure isomers of α,β-dimethyl-phenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid Tetrahedron Letters. 32: 5769-5772. DOI: 10.1016/S0040-4039(00)93551-2  1
1991 Kazmierski WM, Yamamura HI, Hruby VJ. Topographic Design of Peptide Neurotransmitters and Hormones on Stable Backbone Templates: Relation of Conformation and Dynamics to Bioactivity Journal of the American Chemical Society. 113: 2275-2283.  1
1990 Hruby VJ, Fang SA, Knapp R, Kazmierski W, Lui GK, Yamamura HI. Cholecystokinin analogues with high affinity and selectivity for brain membrane receptors. International Journal of Peptide and Protein Research. 35: 566-73. PMID 2401597  1
1990 Benson B, Ebels I, Hruby VJ. Isolation and structure elucidation of bovine pineal arginine vasopressin: Arginine vasotocin not identified International Journal of Peptide and Protein Research. 36: 109-121. PMID 2272747 DOI: 10.1111/J.1399-3011.1990.TB00953.X  1
1990 Lenzen R, Hruby VJ, Tavoloni N. Mechanism of glucagon choleresis in guinea pigs American Journal of Physiology - Gastrointestinal and Liver Physiology. 259. PMID 2173415 DOI: 10.1152/AJPGI.1990.259.5.G736  1
1990 García-Sáinz JA, Macías-Silva M, Hernández-Sotomayor SM, Torres-Márquez ME, Trivedi D, Hruby VJ. Modulation of glucagon actions by phorbol myristate acetate in isolated hepatocytes. Effect of hypothyroidism. Cellular Signalling. 2: 235-43. PMID 2169291 DOI: 10.1016/0898-6568(90)90051-B  0.96
1990 Hruby VJ, Al-Obeidi F, Kazmierski W. Emerging approaches in the molecular design of receptor-selective peptide ligands: Conformational, topographical and dynamic considerations Biochemical Journal. 268: 249-262. PMID 2163604 DOI: 10.1042/BJ2680249  1
1990 Vaughn LK, Wire WS, Davis P, Shimohigashi Y, Toth G, Knapp RJ, Hruby VJ, Burks TF, Yamamura HI. Differentiation between rat brain and mouse vas deferens delta opioid receptors. European Journal of Pharmacology. 177: 99-101. PMID 2160370 DOI: 10.1016/0014-2999(90)90556-L  1
1990 Toth G, Kramer TH, Knapp R, Lui G, Davis P, Burks TF, Yamamura HI, Hruby VJ. [D-Pen2,D-Pen5]enkephalin analogues with increased affinity and selectivity for delta opioid receptors. Journal of Medicinal Chemistry. 33: 249-53. PMID 2153205  1
1990 Nikiforovich GV, Hruby VJ. Examination of the conformational meaning of "δ-address" in the dermenkephalin sequence Biochemical and Biophysical Research Communications. 173: 521-527. PMID 1979733 DOI: 10.1016/S0006-291X(05)80065-8  1
1990 Kawasaki AM, Knapp RJ, Kramer TH, Wire WS, Vasquez OS, Yamamura HI, Burks TF, Hruby VJ. Design and synthesis of highly potent and selective cyclic dynorphin A analogues. Journal of Medicinal Chemistry. 33: 1874-9. PMID 1972964  1
1990 Toth G, Lebl M, Hruby VJ. Chiral thin-layer chromatographic separation of phenylalanine and tyrosine derivatives Journal of Chromatography A. 504: 450-455. DOI: 10.1016/S0021-9673(01)89550-9  1
1990 Hruby VJ, Kazmierski W, Pelton JT, Yamamura HI, Burks TF. Conversion of somatostatin to an opioid peptide: design using a conformational template and topographical constraints European Journal of Pharmacology. 183: 54. DOI: 10.1016/0014-2999(90)91304-T  1
1989 Castrucci AM, Hadley ME, Wilkes BC, Hruby VJ, Sawyer TK. Melanotropin structure-activity studies on melanocytes of the teleost fish, Synbranchus marmoratus. General and Comparative Endocrinology. 74: 209-14. PMID 2714625 DOI: 10.1016/0016-6480(89)90214-1  0.64
1989 Hruby VJ. Designing molecules: Specific peptides for specific receptors Epilepsia. 30. PMID 2570689 DOI: 10.1111/j.1528-1157.1989.tb05814.x  1
1989 Froimowitz M, Hruby VJ. Conformational analysis of enkephalin analogs containing a disulfide bond. Models for delta- and mu-receptor opioid agonists International Journal of Peptide and Protein Research. 34: 88-96. PMID 2553632 DOI: 10.1111/J.1399-3011.1989.TB01495.X  1
1989 Vaughn LK, Knapp RJ, Toth G, Wan YP, Hruby VJ, Yamamura HI. A high affinity, highly selective ligand for the delta opioid receptor: [3H]-[D-Pen2, pCl-Phe4, d-Pen5]enkephalin. Life Sciences. 45: 1001-8. PMID 2552241  0.72
1989 Hruby VJ, Gehrig CA. Recent developments in the design of receptor specific opioid peptides Medicinal Research Reviews. 9: 343-401. PMID 2547125 DOI: 10.1002/med.2610090306  1
1989 Patterson TA, Schulteis G, Alvarado MC, Martinez JL, Bennett EL, Rosenzweig MR, Hruby VJ. Influence of opioid peptides on learning and memory processes in the chick. Behavioral Neuroscience. 103: 429-37. PMID 2539840 DOI: 10.1037/0735-7044.103.2.429  1
1989 Landis G, Lui G, Shook JE, Yamamura HI, Burks TF, Hruby VJ. Synthesis of highly mu and delta opioid receptor selective peptides containing a photoaffinity group. Journal of Medicinal Chemistry. 32: 638-43. PMID 2537426  1
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