| Year |
Citation |
Score |
| 2018 |
Zhou Y, Mowlazadeh Haghighi S, Zoi I, Sawyer JR, Hruby VJ, Cai M. Correction to Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation. Journal of Medicinal Chemistry. PMID 30252463 DOI: 10.1021/acs.jmedchem.8b01423 |
1 |
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| 2018 |
Mowlazadeh Haghighi S, Zhou Y, Dai J, Sawyer JR, Hruby VJ, Cai M. Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH, leads to hMC1R selectivity and pigmentation. European Journal of Medicinal Chemistry. 151: 815-823. PMID 29679901 DOI: 10.1016/j.ejmech.2018.04.021 |
1 |
|
| 2018 |
Merlino F, Zhou Y, Cai M, Carotenuto A, Yousif AM, Brancaccio D, Di Maro S, Zappavigna S, Limatola A, Novellino E, Grieco P, Hruby VJ. Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors. Journal of Medicinal Chemistry. PMID 29660981 DOI: 10.1021/acs.jmedchem.8b00488 |
1 |
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| 2018 |
Durek T, Cromm PM, White AM, Schroeder CI, Kaas Q, Weidmann J, Ahmad Fuaad A, Cheneval O, Harvey PJ, Daly NL, Zhou Y, Dellsén A, Österlund T, Larsson N, Knerr L, ... ... Hruby VJ, et al. Development of novel melanocortin receptor agonists based on the cyclic peptide framework of sunflower trypsin inhibitor-1. Journal of Medicinal Chemistry. PMID 29605997 DOI: 10.1021/acs.jmedchem.8b00170 |
1 |
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| 2017 |
Zhou Y, Mowlazadeh Haghighi S, Zoi I, Sawyer JR, Hruby VJ, Cai M. Design of MC1R selective γ-MSH analogues with canonical amino acids leads to potency and pigmentation. Journal of Medicinal Chemistry. PMID 29094944 DOI: 10.1021/acs.jmedchem.7b01295 |
1 |
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| 2017 |
Vardanyan RS, Cain JP, Haghighi SM, Kumirov VK, McIntosh MI, Sandweiss AJ, Porreca F, Hruby VJ. Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain. Journal of Heterocyclic Chemistry. 54: 1228-1235. PMID 28819330 DOI: 10.1002/jhet.2696 |
1 |
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| 2017 |
Cai M, Marelli UK, Mertz B, Beck JG, Opperer F, Rechenmacher F, Kessler H, Hruby VJ. Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists. Biochemistry. PMID 28715181 DOI: 10.1021/acs.biochem.7b00407 |
1 |
|
| 2017 |
Stefanucci A, Lei W, Hruby VJ, Macedonio G, Luisi G, Carradori S, Streicher JM, Mollica A. Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers. Future Medicinal Chemistry. PMID 28635314 DOI: 10.4155/fmc-2016-0232 |
0.72 |
|
| 2017 |
Rinne P, Rami M, Nuutinen SL, Santovito D, van der Vorst EPC, Guillamat-Prats R, Lyytikäinen LP, Raitoharju E, Oksala N, Ring L, Cai M, Hruby VJ, Lehtimäki TJ, Weber C, Steffens S. Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages. Circulation. PMID 28450348 DOI: 10.1161/CIRCULATIONAHA.116.025889 |
1 |
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| 2017 |
Remesic MV, Hruby VJ, Porreca F, Lee YS. Recent Advances in the Realm of Allosteric Modulators for the Opioid Receptors for Future Therapeutics. Acs Chemical Neuroscience. PMID 28368571 DOI: 10.1021/acschemneuro.7b00090 |
1 |
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| 2016 |
Ramos-Colon CN, Lee YS, Remesic MV, Hall SM, LaVigne J, Davis P, Sandweiss AJ, McIntosh MI, Hanson J, Largent-Milnes TM, Vanderah TW, Streicher JM, Porreca F, Hruby VJ. Structure Activity Relationships of [des-Arg(7)]- Dynorphin A Analogues at the Kappa Opioid Receptor. Journal of Medicinal Chemistry. PMID 27797517 DOI: 10.1021/acs.jmedchem.6b01411 |
1 |
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| 2016 |
Lee YS, Remesic M, Ramos-Colon C, Hall SM, Kuzmin A, Rankin D, Porreca F, Lai J, Hruby VJ. Cyclic non-opioid dynorphin A analogues for the bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. PMID 27756562 DOI: 10.1016/j.bmcl.2016.10.010 |
1 |
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| 2016 |
Hall SM, LeBaron L, Ramos-Colon CN, Qu C, Xie JY, Porreca F, Lai J, Lee YS, Hruby VJ. Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain. Acs Chemical Neuroscience. PMID 27619237 DOI: 10.1021/acschemneuro.6b00258 |
1 |
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| 2016 |
Cai M, Hruby VJ. Design of Cyclized Selective Melanotropins. Biopolymers. PMID 27561155 DOI: 10.1002/bip.22976 |
1 |
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| 2016 |
Islam MR, Yang L, Lee YS, Hruby VJ, Karamyan VT, Abbruscato TJ. Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment. Current Pharmaceutical Design. PMID 27510489 |
1 |
|
| 2016 |
Lee YS, Kupp R, Remesic M, Ramos-Colon C, Hall SM, Chan C, Rankin D, Lai J, Porreca F, Hruby VJ. Various modifications of the amphipathic dynorphin A phamacophore for rat brain bradykinin receptors. Chemical Biology & Drug Design. PMID 27203574 DOI: 10.1111/cbdd.12789 |
1 |
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| 2016 |
Remesic M, Lee YS, Hruby VJ. Cyclic Opioid Peptides. Current Medicinal Chemistry. PMID 27117332 |
1 |
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| 2016 |
Cai M, Hruby VJ. The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases. Current Protein & Peptide Science. PMID 26916163 |
1 |
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| 2016 |
Hall SM, Lee YS, Hruby VJ. Dynorphin A analogs for the treatment of chronic neuropathic pain. Future Medicinal Chemistry. PMID 26824470 DOI: 10.4155/fmc.15.164 |
1 |
|
| 2015 |
Huynh AS, Estrella V, Stark VE, Cohen AS, Chen T, Casagni TJ, Josan JS, Lloyd MC, Johnson J, Kim J, Hruby VJ, Vagner J, Morse DL. Tumor Targeting and Pharmacokinetics of a Near Infrared Fluorescent-labeled δ-Opioid Receptor Antagonist Agent, Dmt-Tic-Cy5. Molecular Pharmaceutics. PMID 26713599 DOI: 10.1021/acs.molpharmaceut.5b00760 |
1 |
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| 2015 |
Deekonda S, Rankin D, Davis P, Lai J, Vanderah TW, Porecca F, Hruby VJ. Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands. Bioorganic & Medicinal Chemistry. PMID 26712115 DOI: 10.1016/j.bmc.2015.11.030 |
0.76 |
|
| 2015 |
Deekonda S, Cole J, Sunna S, Rankin D, Largent-Milnes TM, Davis P, BassiriRad NM, Lai J, Vanderah TW, Porecca F, Hruby VJ. Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations. Bioorganic & Medicinal Chemistry Letters. PMID 26611918 DOI: 10.1016/j.bmcl.2015.10.081 |
1 |
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| 2015 |
Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P. Discovery of Novel Potent and Selective Agonists at the Melanocortin‑3 Receptor. Journal of Medicinal Chemistry. PMID 26599352 DOI: 10.1021/acs.jmedchem.5b01285 |
0.76 |
|
| 2015 |
Giri AK, Apostol CR, Wang Y, Forte BL, Largent-Milnes TM, Davis P, Rankin D, Molnar G, Olson KM, Porreca F, Vanderah TW, Hruby VJ. Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain. Journal of Medicinal Chemistry. PMID 26465170 DOI: 10.1021/acs.jmedchem.5b01170 |
1 |
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| 2015 |
Shukla C, Koch LG, Britton SL, Cai M, Hruby VJ, Bednarek M, Novak CM. Contribution of regional brain melanocortin receptor subtypes to elevated activity energy expenditure in lean, active rats. Neuroscience. PMID 26404873 DOI: 10.1016/j.neuroscience.2015.09.035 |
1 |
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| 2015 |
Deekonda S, Wugalter L, Rankin D, Largent-Milnes TM, Davis P, Wang Y, Bassirirad NM, Lai J, Kulkarni V, Vanderah TW, Porreca F, Hruby VJ. Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 26323872 DOI: 10.1016/j.bmcl.2015.07.064 |
1 |
|
| 2015 |
Deekonda S, Rankin D, Davis P, Lai J, Porreca F, Hruby VJ. Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors. Bioorganic & Medicinal Chemistry Letters. 25: 4148-52. PMID 26316468 DOI: 10.1016/j.bmcl.2015.08.014 |
1 |
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| 2015 |
Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands. Bioorganic & Medicinal Chemistry. 23: 6185-94. PMID 26299827 DOI: 10.1016/j.bmc.2015.07.071 |
1 |
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| 2015 |
Lee YS, Hall SM, Ramos-Colon C, Remesic M, Rankin D, Vanderah TW, Porreca F, Lai J, Hruby VJ. Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors. Receptors & Clinical Investigation. 2. PMID 26221618 DOI: 10.14800/rci.517 |
1 |
|
| 2015 |
Cai M, Marelli UK, Bao J, Beck JG, Opperer F, Rechenmacher F, McLeod KR, Zingsheim MR, Doedens L, Kessler H, Hruby VJ. Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors. Journal of Medicinal Chemistry. 58: 6359-67. PMID 26218460 DOI: 10.1021/acs.jmedchem.5b00102 |
1 |
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| 2015 |
Nair P, Yamamoto T, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 25: 3716-20. PMID 26212775 DOI: 10.1016/j.bmcl.2015.06.030 |
1 |
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| 2015 |
Mehr-un-Nisa, Munawar MA, Lee YS, Rankin D, Munir J, Lai J, Khan MA, Hruby VJ. Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs. Bioorganic & Medicinal Chemistry. 23: 1251-9. PMID 25703306 DOI: 10.1016/j.bmc.2015.01.047 |
1 |
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| 2015 |
Van der Poorten O, Fehér K, Buysse K, Feytens D, Zoi I, Schwartz SD, Martins JC, Tourwé D, Cai M, Hruby VJ, Ballet S. Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist. Acs Medicinal Chemistry Letters. 6: 192-7. PMID 25699148 DOI: 10.1021/ml500436s |
1 |
|
| 2015 |
Bird MF, Vardanyan RS, Hruby VJ, Calò G, Guerrini R, Salvadori S, Trapella C, McDonald J, Rowbotham DJ, Lambert DG. Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands. British Journal of Anaesthesia. 114: 646-56. PMID 25680364 DOI: 10.1093/bja/aeu454 |
1 |
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| 2015 |
Lee YS, Hall SM, Ramos-Colon C, Remesic M, LeBaron L, Nguyen A, Rankin D, Porreca F, Lai J, Hruby VJ. Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 25: 30-3. PMID 25434001 DOI: 10.1016/j.bmcl.2014.11.026 |
1 |
|
| 2015 |
Banday AH, Jeelani S, Hruby VJ. Cancer vaccine adjuvants--recent clinical progress and future perspectives. Immunopharmacology and Immunotoxicology. 37: 1-11. PMID 25318595 DOI: 10.3109/08923973.2014.971963 |
1 |
|
| 2015 |
Banday AH, Kulkarni VV, Hruby VJ. Design, synthesis, and biological and docking studies of novel epipodophyllotoxin-chalcone hybrids as potential anticancer agents Medchemcomm. 6: 94-104. DOI: 10.1039/c4md00325j |
1 |
|
| 2015 |
Cai M, Marelli UK, Bao J, Beck JG, Opperer F, Rechenmacher F, McLeod KR, Zingsheim MR, Doedens L, Kessler H, Hruby VJ. Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors Journal of Medicinal Chemistry. 58: 6359-6367. DOI: 10.1021/acs.jmedchem.5b00102 |
1 |
|
| 2015 |
Deekonda S, Rankin D, Davis P, Lai J, Porreca F, Hruby VJ. Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.08.014 |
1 |
|
| 2015 |
Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands Bioorganic and Medicinal Chemistry. 23: 6185-6194. DOI: 10.1016/j.bmc.2015.07.071 |
1 |
|
| 2015 |
Mollica A, Stefanucci A, Costante R, Hruby VJ. Rational approach to the design of bioactive peptidomimetics: Recent developments in opioid agonist peptides Studies in Natural Products Chemistry. 46: 27-68. DOI: 10.1016/B978-0-444-63462-7.00002-6 |
1 |
|
| 2014 |
Fernandes SM, Lee YS, Gillies RJ, Hruby VJ. Synthesis and evaluation of bivalent ligands for binding to the human melanocortin-4 receptor. Bioorganic & Medicinal Chemistry. 22: 6360-5. PMID 25438759 DOI: 10.1016/j.bmc.2014.09.055 |
1 |
|
| 2014 |
Lee YS, Rankin D, Hall SM, Ramos-Colon C, Ortiz JJ, Kupp R, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of non-opioid [des-Arg(7)]-dynorphin A analogues for bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 24: 4976-9. PMID 25282551 DOI: 10.1016/j.bmcl.2014.09.033 |
1 |
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| 2014 |
Mollica A, Carotenuto A, Novellino E, Limatola A, Costante R, Pinnen F, Stefanucci A, Pieretti S, Borsodi A, Samavati R, Zador F, Benyhe S, Davis P, Porreca F, Hruby VJ. Novel cyclic biphalin analogue with improved antinociceptive properties. Acs Medicinal Chemistry Letters. 5: 1032-6. PMID 25221662 DOI: 10.1021/ml500241n |
1 |
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| 2014 |
Lee YS, Muthu D, Hall SM, Ramos-Colon C, Rankin D, Hu J, Sandweiss AJ, De Felice M, Xie JY, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord. Journal of the American Chemical Society. 136: 6608-16. PMID 24742335 DOI: 10.1021/ja501677q |
1 |
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| 2014 |
Vardanyan RS, Hruby VJ. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Medicinal Chemistry. 6: 385-412. PMID 24635521 DOI: 10.4155/fmc.13.215 |
1 |
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| 2014 |
Giri AK, Hruby VJ. Investigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of pain. Expert Opinion On Investigational Drugs. 23: 227-41. PMID 24329035 DOI: 10.1517/13543784.2014.856879 |
1 |
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| 2014 |
Banday AH, Hruby VJ. Regioselective N/C-heterocyclization of allenylindium bromide across aryl azides: One-pot synthesis of 5-methyl-1,2,3-triazoles Synlett. 25: 1859-1862. DOI: 10.1055/s-0034-1378327 |
1 |
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| 2014 |
Karthikeyan B, Giri AK, Hruby VJ. Entrap and release of Phe–Phe nanotubes in sol–gel derived silicate matrix: study through nanosilver interaction Journal of Sol-Gel Science and Technology. 72: 534-542. DOI: 10.1007/s10971-014-3470-x |
1 |
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| 2013 |
Lee YS, Qu HC, Davis P, Ma SW, Vardanyan R, Lai J, Porreca F, Hruby VJ. Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities. Acs Medicinal Chemistry Letters. 4: 656-659. PMID 24648867 DOI: 10.1021/ml400115n |
1 |
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| 2013 |
Podolsky AT, Sandweiss A, Hu J, Bilsky EJ, Cain JP, Kumirov VK, Lee YS, Hruby VJ, Vardanyan RS, Vanderah TW. Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain. Life Sciences. 93: 1010-6. PMID 24084045 DOI: 10.1016/j.lfs.2013.09.016 |
1 |
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| 2013 |
Nair P, Yamamoto T, Largent-Milnes TM, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 23: 4975-8. PMID 23899615 DOI: 10.1016/j.bmcl.2013.06.065 |
1 |
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| 2013 |
Alleti R, Vagner J, Dehigaspitiya DC, Moberg VE, Elshan NG, Tafreshi NK, Brabez N, Weber CS, Lynch RM, Hruby VJ, Gillies RJ, Morse DL, Mash EA. Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors. Bioorganic & Medicinal Chemistry. 21: 5029-38. PMID 23890524 DOI: 10.1016/j.bmc.2013.06.052 |
1 |
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| 2013 |
Barkey NM, Preihs C, Cornnell HH, Martinez G, Carie A, Vagner J, Xu L, Lloyd MC, Lynch VM, Hruby VJ, Sessler JL, Sill KN, Gillies RJ, Morse DL. Development and in vivo quantitative magnetic resonance imaging of polymer micelles targeted to the melanocortin 1 receptor. Journal of Medicinal Chemistry. 56: 6330-8. PMID 23863078 DOI: 10.1021/jm4005576 |
1 |
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| 2013 |
Largent-Milnes TM, Brookshire SW, Skinner DP, Hanlon KE, Giuvelis D, Yamamoto T, Davis P, Campos CR, Nair P, Deekonda S, Bilsky EJ, Porreca F, Hruby VJ, Vanderah TW. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. The Journal of Pharmacology and Experimental Therapeutics. 347: 7-19. PMID 23860305 DOI: 10.1124/jpet.113.205245 |
1 |
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| 2013 |
Petrov RR, Lee YS, Vardanyan RS, Liu L, Ma SW, Davis P, Lai J, Porreca F, Vanderah TW, Hruby VJ. Effect of anchoring 4-anilidopiperidines to opioid peptides. Bioorganic & Medicinal Chemistry Letters. 23: 3434-7. PMID 23623418 DOI: 10.1016/j.bmcl.2013.03.065 |
1 |
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| 2013 |
Hruby VJ. Adventures in peptides and science with students! the joys of research. Biopolymers. 100: 127-31. PMID 23616095 DOI: 10.1002/bip.22179 |
1 |
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| 2013 |
Mollica A, Pinnen F, Costante R, Locatelli M, Stefanucci A, Pieretti S, Davis P, Lai J, Rankin D, Porreca F, Hruby VJ. Biological active analogues of the opioid peptide biphalin: mixed α/β(3)-peptides. Journal of Medicinal Chemistry. 56: 3419-23. PMID 23547584 DOI: 10.1021/jm301456c |
1 |
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| 2013 |
Brabez N, Saunders K, Nguyen KL, Jayasundera TB, Weber C, Lynch RM, Chassaing G, Lavielle S, Hruby VJ. Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting. Acs Medicinal Chemistry Letters. 4: 98-102. PMID 23524643 DOI: 10.1021/ml300312b |
1 |
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| 2013 |
Brabez N, Nguyen KL, Saunders K, Lacy R, Xu L, Gillies RJ, Lynch RM, Chassaing G, Lavielle S, Hruby VJ. Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment. Bioorganic & Medicinal Chemistry Letters. 23: 2422-5. PMID 23489620 DOI: 10.1016/j.bmcl.2013.02.022 |
1 |
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| 2013 |
Mehr-Un-Nisa, Munawar MA, Hall GB, Roberts SA, Hruby VJ. tert-Butyl 4-(3,4-dichloro-anilino)piperidine-1-carboxyl-ate. Acta Crystallographica. Section E, Structure Reports Online. 69: o205. PMID 23424488 DOI: 10.1107/S1600536812051896 |
1 |
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| 2013 |
Hruby VJ, Cai M. Design of peptide and peptidomimetic ligands with novel pharmacological activity profiles. Annual Review of Pharmacology and Toxicology. 53: 557-80. PMID 23294313 DOI: 10.1146/annurev-pharmtox-010510-100456 |
1 |
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| 2013 |
Cai M, Stankova M, Muthu D, Mayorov A, Yang Z, Trivedi D, Cabello C, Hruby VJ. An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells. Biochemistry. 52: 752-64. PMID 23276279 DOI: 10.1021/bi300723f |
1 |
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| 2013 |
Rinne P, Nordlund W, Heinonen I, Penttinen AM, Saraste A, Ruohonen ST, Mäkelä S, Vähätalo L, Kaipio K, Cai M, Hruby VJ, Ruohonen S, Savontaus E. α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction. Cardiovascular Research. 97: 360-8. PMID 23131503 DOI: 10.1093/cvr/cvs335 |
1 |
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| 2012 |
Xu L, Josan JS, Vagner J, Caplan MR, Hruby VJ, Mash EA, Lynch RM, Morse DL, Gillies RJ. Heterobivalent ligands target cell-surface receptor combinations in vivo. Proceedings of the National Academy of Sciences of the United States of America. 109: 21295-300. PMID 23236171 DOI: 10.1073/pnas.1211762109 |
1 |
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| 2012 |
Mollica A, Pinnen F, Stefanucci A, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2. Journal of Medicinal Chemistry. 55: 8477-82. PMID 22966938 DOI: 10.1021/jm300947s |
1 |
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| 2012 |
Tumati S, Largent-Milnes TM, Keresztes AI, Yamamoto T, Vanderah TW, Roeske WR, Hruby VJ, Varga EV. Tachykinin NKâ‚ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation. European Journal of Pharmacology. 684: 64-70. PMID 22724132 DOI: 10.1016/j.ejphar.2012.03.025 |
1 |
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| 2012 |
Mollica A, Pinnen F, Stefanucci A, Feliciani F, Campestre C, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues. Journal of Medicinal Chemistry. 55: 3027-35. PMID 22394120 DOI: 10.1021/jm201402v |
1 |
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| 2012 |
Liu Z, Mehta SJ, Lee KS, Grossman B, Qu H, Gu X, Nichol GS, Hruby VJ. Thio-Claisen rearrangement used in preparing anti-β-functionalized γ,δ-unsaturated amino acids: scope and limitations. The Journal of Organic Chemistry. 77: 1289-300. PMID 22283513 DOI: 10.1021/jo201753q |
1 |
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| 2012 |
Liu Z, Mehta SJ, Hruby VJ. Strategies for asymmetric synthesis of amino acids withγ,δ -Unsaturation Organic Preparations and Procedures International. 44: 222-255. DOI: 10.1080/00304948.2012.676507 |
1 |
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| 2011 |
Vardanyan RS, Danagulyan GG, Mkrtchyan AD, Hruby VJ. Recyclization reactions of 1-alkylpyrimidinium salts. Heterocyclic Communications. 17: 129-133. PMID 25400328 DOI: 10.1515/hc.2011.025 |
1 |
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| 2011 |
Hruby VJ, Cai M, Nyberg J, Muthu D. Approaches to the rational design of selective melanocortin receptor antagonists. Expert Opinion On Drug Discovery. 6: 543-57. PMID 22646078 DOI: 10.1517/17460441.2011.565743 |
1 |
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| 2011 |
Barkey NM, Tafreshi NK, Josan JS, De Silva CR, Sill KN, Hruby VJ, Gillies RJ, Morse DL, Vagner J. Development of melanoma-targeted polymer micelles by conjugation of a melanocortin 1 receptor (MC1R) specific ligand. Journal of Medicinal Chemistry. 54: 8078-84. PMID 22011200 DOI: 10.1021/jm201226w |
1 |
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| 2011 |
Brabez N, Lynch RM, Xu L, Gillies RJ, Chassaing G, Lavielle S, Hruby VJ. Design, synthesis, and biological studies of efficient multivalent melanotropin ligands: tools toward melanoma diagnosis and treatment. Journal of Medicinal Chemistry. 54: 7375-84. PMID 21928837 DOI: 10.1021/jm2009937 |
1 |
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| 2011 |
Vardanyan R, Kumirov VK, Nichol GS, Davis P, Liktor-Busa E, Rankin D, Varga E, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands. Bioorganic & Medicinal Chemistry. 19: 6135-42. PMID 21925887 DOI: 10.1016/j.bmc.2011.08.027 |
1 |
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| 2011 |
Grieco P, Brancaccio D, Novellino E, Hruby VJ, Carotenuto A. Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor. European Journal of Medicinal Chemistry. 46: 3721-33. PMID 21652123 DOI: 10.1016/j.ejmech.2011.05.038 |
1 |
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| 2011 |
Josan JS, Handl HL, Sankaranarayanan R, Xu L, Lynch RM, Vagner J, Mash EA, Hruby VJ, Gillies RJ. Cell-specific targeting by heterobivalent ligands. Bioconjugate Chemistry. 22: 1270-8. PMID 21639139 DOI: 10.1021/bc1004284 |
1 |
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| 2011 |
Hanlon KE, Herman DS, Agnes RS, Largent-Milnes TM, Kumarasinghe IR, Ma SW, Guo W, Lee YS, Ossipov MH, Hruby VJ, Lai J, Porreca F, Vanderah TW. Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain. Brain Research. 1395: 1-11. PMID 21550594 DOI: 10.1016/j.brainres.2011.04.024 |
1 |
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| 2011 |
Wu Z, Hruby VJ. Backbone alignment modeling of the structure-activity relationships of opioid ligands. Journal of Chemical Information and Modeling. 51: 1151-64. PMID 21488692 DOI: 10.1021/ci2000852 |
1 |
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| 2011 |
Mayorov AV, Cai M, Palmer ES, Tanaka DK, Cain JP, Dedek MM, Tan B, Trivedi D, Hruby VJ. Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 21: 3099-102. PMID 21486697 DOI: 10.1016/j.bmcl.2011.03.019 |
1 |
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| 2011 |
Yamamoto T, Nair P, Largent-Milnes TM, Jacobsen NE, Davis P, Ma SW, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. Journal of Medicinal Chemistry. 54: 2029-38. PMID 21366266 DOI: 10.1021/jm101023r |
1 |
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| 2011 |
Josan JS, De Silva CR, Yoo B, Lynch RM, Pagel MD, Vagner J, Hruby VJ. Fluorescent and lanthanide labeling for ligand screens, assays, and imaging. Methods in Molecular Biology (Clifton, N.J.). 716: 89-126. PMID 21318902 DOI: 10.1007/978-1-61779-012-6_6 |
1 |
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| 2011 |
Cai M, Liu Z, Qu H, Fan H, Zheng Z, Hruby VJ. Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma. European Journal of Pharmacology. 660: 188-93. PMID 21315067 DOI: 10.1016/j.ejphar.2011.01.032 |
1 |
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| 2011 |
Hruby VJ, Cai M, Cain J, Nyberg J, Trivedi D. Design of novel melanocortin receptor ligands: multiple receptors, complex pharmacology, the challenge. European Journal of Pharmacology. 660: 88-93. PMID 21208601 DOI: 10.1016/j.ejphar.2010.10.109 |
1 |
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| 2011 |
Lee YS, Kulkarani V, Cowell SM, Ma SW, Davis P, Hanlon KE, Vanderah TW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of potent μ and δ opioid agonists with high lipophilicity. Journal of Medicinal Chemistry. 54: 382-6. PMID 21128594 DOI: 10.1021/jm100982d |
1 |
|
| 2011 |
Mollica A, Pinnen F, Feliciani F, Stefanucci A, Lucente G, Davis P, Porreca F, Ma SW, Lai J, Hruby VJ. New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4' positions and non-hydrazine linkers. Amino Acids. 40: 1503-11. PMID 20924622 DOI: 10.1007/s00726-010-0760-7 |
1 |
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| 2011 |
Vardanyan R, Kumirov VK, Hruby VJ. Improved synthesis of d,l-fluorocitric acid Journal of Fluorine Chemistry. 132: 920-924. DOI: 10.1016/j.jfluchem.2011.07.006 |
1 |
|
| 2011 |
Hruby VJ. Collaborations Between Chemists and Biologists Collaborative Computational Technologies For Biomedical Research. 113-120. DOI: 10.1002/9781118026038.ch7 |
1 |
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| 2010 |
Nichol GS, Vardanyan R, Hruby VJ. Synthesis and Crystallographic Study of N'-(1-benzylpiperidin-4-yl)acetohydrazide. Journal of Chemical Crystallography. 40: 961-964. PMID 25505832 DOI: 10.1007/s10870-010-9771-1 |
1 |
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| 2010 |
Nichol GS, Kumirov VK, Vardanyan R, Hruby VJ. Proton sharing and transfer in some zwitterionic compounds based on 4-oxo-4-((1-phenethylpiperidin-4-yl)(phenyl)amino)alcanoic acids. Crystengcomm / Rsc. 12: 3651-3657. PMID 25425961 DOI: 10.1039/B923698H |
1 |
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| 2010 |
Largent-Milnes TM, Yamamoto T, Nair P, Moulton JW, Hruby VJ, Lai J, Porreca F, Vanderah TW. Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. British Journal of Pharmacology. 161: 986-1001. PMID 20977451 DOI: 10.1111/j.1476-5381.2010.00824.x |
1 |
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| 2010 |
Giordano C, Sansone A, Masi A, Lucente G, Punzi P, Mollica A, Pinnen F, Feliciani F, Cacciatore I, Davis P, Lai J, Ma SW, Porreca F, Hruby V. Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. European Journal of Medicinal Chemistry. 45: 4594-600. PMID 20692738 DOI: 10.1016/j.ejmech.2010.07.022 |
1 |
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| 2010 |
Mayorov AV, Cai M, Palmer ES, Liu Z, Cain JP, Vagner J, Trivedi D, Hruby VJ. Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors. Peptides. 31: 1894-905. PMID 20688117 DOI: 10.1016/j.peptides.2010.06.026 |
1 |
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| 2010 |
Yamamoto T, Nair P, Jacobsen NE, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines. Journal of Medicinal Chemistry. 53: 5491-501. PMID 20617791 DOI: 10.1021/jm100157m |
1 |
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| 2010 |
Lee YS, Fernandes S, Kulkarani V, Mayorov A, Davis P, Ma SW, Brown K, Gillies RJ, Lai J, Porreca F, Hruby VJ. Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. Bioorganic & Medicinal Chemistry Letters. 20: 4080-4. PMID 20547453 DOI: 10.1016/j.bmcl.2010.05.078 |
1 |
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| 2010 |
Morse DL, Balagurunathan Y, Hostetter G, Trissal M, Tafreshi NK, Burke N, Lloyd M, Enkemann S, Coppola D, Hruby VJ, Gillies RJ, Han H. Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray. Biochemical Pharmacology. 80: 748-54. PMID 20510208 DOI: 10.1016/j.bcp.2010.05.018 |
1 |
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| 2010 |
Doedens L, Opperer F, Cai M, Beck JG, Dedek M, Palmer E, Hruby VJ, Kessler H. Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies. Journal of the American Chemical Society. 132: 8115-28. PMID 20496895 DOI: 10.1021/ja101428m |
1 |
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| 2010 |
Torino D, Mollica A, Pinnen F, Feliciani F, Lucente G, Fabrizi G, Portalone G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues. Journal of Medicinal Chemistry. 53: 4550-4. PMID 20476738 DOI: 10.1021/jm1001343 |
1 |
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| 2010 |
Xu L, Vagner J, Alleti R, Rao V, Jagadish B, Morse DL, Hruby VJ, Gillies RJ, Mash EA. Synthesis and characterization of a Eu-DTPA-PEGO-MSH(4) derivative for evaluation of binding of multivalent molecules to melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 20: 2489-92. PMID 20304640 DOI: 10.1016/j.bmcl.2010.03.007 |
1 |
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| 2010 |
Juni A, Cai M, Stankova M, Waxman AR, Arout C, Klein G, Dahan A, Hruby VJ, Mogil JS, Kest B. Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor. Anesthesiology. 112: 181-8. PMID 19996949 DOI: 10.1097/ALN.0b013e3181c53849 |
1 |
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| 2010 |
De Silva CR, Vagner J, Lynch R, Gillies RJ, Hruby VJ. Optimization of time-resolved fluorescence assay for detection of europium-tetraazacyclododecyltetraacetic acid-labeled ligand-receptor interactions. Analytical Biochemistry. 398: 15-23. PMID 19852924 DOI: 10.1016/j.ab.2009.10.031 |
1 |
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| 2010 |
Hruby VJ, Alves I, Cowell S, Salamon Z, Tollin G. Use of plasmon waveguide resonance (PWR) spectroscopy for examining binding, signaling and lipid domain partitioning of membrane proteins. Life Sciences. 86: 569-74. PMID 19281827 DOI: 10.1016/j.lfs.2009.02.027 |
1 |
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| 2010 |
Liu Z, Qu H, Gu X, Lee KS, Grossman B, Kumirov VK, Hruby VJ. Novel anti-β-functionalized γ,δ-unsaturated amino acids via a thio-Claisen rearrangement Tetrahedron Letters. 51: 3518-3520. DOI: 10.1016/j.tetlet.2010.04.102 |
1 |
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| 2009 |
Kumarasinghe IR, Hruby VJ, Nichol GS. 1-(4-Methoxy-phen-yl)-3-phenyl-1H-pyrazol-5-amine. Acta Crystallographica. Section E, Structure Reports Online. 65: o1170. PMID 21583972 DOI: 10.1107/S1600536809015463 |
1 |
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| 2009 |
Yamamoto T, Nair P, Jacobsen NE, Vagner J, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 52: 5164-75. PMID 20560643 DOI: 10.1021/jm900473p |
1 |
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| 2009 |
Hruby VJ. Organic chemistry and biology: chemical biology through the eyes of collaboration. The Journal of Organic Chemistry. 74: 9245-64. PMID 20000552 DOI: 10.1021/jo901767e |
1 |
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| 2009 |
Yamamoto T, Nair P, Ma SW, Davis P, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety. Bioorganic & Medicinal Chemistry. 17: 7337-43. PMID 19762245 DOI: 10.1016/j.bmc.2009.08.035 |
1 |
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| 2009 |
Yang Y, Hruby VJ, Chen M, Crasto C, Cai M, Harmon CM. Novel binding motif of ACTH analogues at the melanocortin receptors. Biochemistry. 48: 9775-84. PMID 19743876 DOI: 10.1021/bi900634e |
1 |
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| 2009 |
Cai M, Nyberg J, Hruby VJ. Melanotropins as drugs for the treatment of obesity and other feeding disorders: potential and problems. Current Topics in Medicinal Chemistry. 9: 554-63. PMID 19689365 DOI: 10.2174/156802609788897817 |
1 |
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| 2009 |
Xu L, Vagner J, Josan J, Lynch RM, Morse DL, Baggett B, Han H, Mash EA, Hruby VJ, Gillies RJ. Enhanced targeting with heterobivalent ligands. Molecular Cancer Therapeutics. 8: 2356-65. PMID 19671749 DOI: 10.1158/1535-7163.MCT-08-1183 |
1 |
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| 2009 |
Torino D, Mollica A, Pinnen F, Lucente G, Feliciani F, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue. Bioorganic & Medicinal Chemistry Letters. 19: 4115-8. PMID 19560919 DOI: 10.1016/j.bmcl.2009.06.008 |
1 |
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| 2009 |
Vardanyan R, Vijay G, Nichol GS, Liu L, Kumarasinghe I, Davis P, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorganic & Medicinal Chemistry. 17: 5044-53. PMID 19540763 DOI: 10.1016/j.bmc.2009.05.065 |
1 |
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| 2009 |
Kumarasinghe IR, Hruby VJ, Nichol GS. 3-[1-(4-Sulfamoylphenyl)-5-p-tolyl-1H-pyrazol-3-yl]propanoic acid and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl]propanoic acid-dichloromethane-diethyl ether-water (2/0.72/1/1). Acta Crystallographica. Section C, Crystal Structure Communications. 65: o296-9. PMID 19498242 DOI: 10.1107/S010827010901676X |
1 |
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| 2009 |
Qu H, Cai M, Mayorov AV, Grieco P, Zingsheim M, Trivedi D, Hruby VJ. Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor. Journal of Medicinal Chemistry. 52: 3627-35. PMID 19473029 DOI: 10.1021/jm801300c |
1 |
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| 2009 |
Josan JS, Morse DL, Xu L, Trissal M, Baggett B, Davis P, Vagner J, Gillies RJ, Hruby VJ. Solid-phase synthetic strategy and bioevaluation of a labeled delta-opioid receptor ligand Dmt-Tic-Lys for in vivo imaging. Organic Letters. 11: 2479-82. PMID 19445485 DOI: 10.1021/ol900200k |
1 |
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| 2009 |
Nair P, Yamamoto T, Kulkarni V, Moye S, Navratilova E, Davis P, Largent T, Ma SW, Yamamura HI, Vanderah T, Lai J, Porreca F, Hruby VJ. Novel bifunctional peptides as opioid agonists and NK-1 antagonists. Advances in Experimental Medicine and Biology. 611: 537-8. PMID 19400302 DOI: 10.1007/978-0-387-73657-0_235 |
1 |
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| 2009 |
Lee Y, Petrov R, Kulkarni V, Min BJ, Ma SW, Davis P, Oyarzo J, Vanderah T, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety. Advances in Experimental Medicine and Biology. 611: 517-8. PMID 19400292 DOI: 10.1007/978-0-387-73657-0_225 |
1 |
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| 2009 |
Fernandes SM, Sankaranarayanan R, Xu L, Josan J, Vagner J, Gillies R, Hruby VJ. Synthesis of bivalent MSH ligands and evaluation of their binding to hMC4R using MSH lanthaligand. Advances in Experimental Medicine and Biology. 611: 433-4. PMID 19400253 DOI: 10.1007/978-0-387-73657-0_186 |
1 |
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| 2009 |
Josan JS, Sankaranarayanan R, Handl HL, Fernandes S, Xu L, Vagner J, Gillies RJ, Hruby VJ. Heterobivalent ligands crosslink multiple cell-surface receptors--a step towards personal medicine. Advances in Experimental Medicine and Biology. 611: 413-4. PMID 19400245 DOI: 10.1007/978-0-387-73657-0_178 |
1 |
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| 2009 |
Hruby VJ, Cai M, Dedek M, Qu H, Palmer E, Mayorov A, Trivedi D, Tsaprailis G, Yang Y. Peptide and non-peptide mimetics utilize different pathways for signal transduction. Advances in Experimental Medicine and Biology. 611: 305-7. PMID 19400204 DOI: 10.1007/978-0-387-73657-0_137 |
1 |
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| 2009 |
Kessler H, Chatterjee J, Doedens L, Operrer F, Biron E, Hoyer D, Schmid H, Gilon C, Hruby VJ, Mierkes DF. New perspective in peptide chemistry by N-alkylation. Advances in Experimental Medicine and Biology. 611: 229-31. PMID 19400173 DOI: 10.1007/978-0-387-73657-0_106 |
1 |
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| 2009 |
Kulkarni VV, Lee YS, Salibay C, Davis P, Ma SW, Porreca F, Hruby VJ. Novel analogues of bifunctional ligands for opioid and melanocortin 4 receptor. Advances in Experimental Medicine and Biology. 611: 195-6. PMID 19400157 DOI: 10.1007/978-0-387-73657-0_90 |
1 |
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| 2009 |
Min BJ, Mayorov AV, Cai M, Palmer E, Hruby VJ. Design and parallel synthesis of new bicyclic small molecules for targeting the melanocortin receptors. Advances in Experimental Medicine and Biology. 611: 187-8. PMID 19400153 DOI: 10.1007/978-0-387-73657-0_86 |
1 |
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| 2009 |
Kumarasinghe IR, Hruby VJ, Nichol GS. 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]propionic acid and the corresponding methyl ester. Acta Crystallographica. Section C, Crystal Structure Communications. 65: o163-6. PMID 19346614 DOI: 10.1107/S010827010900941X |
1 |
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| 2009 |
Yang Y, Cai M, Chen M, Qu H, McPherson D, Hruby V, Harmon CM. Key amino acid residues in the melanocortin-4 receptor for nonpeptide THIQ specific binding and signaling. Regulatory Peptides. 155: 46-54. PMID 19303903 DOI: 10.1016/j.regpep.2009.03.006 |
1 |
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| 2009 |
Zhang W, Gardell S, Zhang D, Xie JY, Agnes RS, Badghisi H, Hruby VJ, Rance N, Ossipov MH, Vanderah TW, Porreca F, Lai J. Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. Brain : a Journal of Neurology. 132: 778-87. PMID 19050032 DOI: 10.1093/brain/awn330 |
1 |
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| 2009 |
Liu Z, Qu H, Gu X, Min BJ, Nyberg J, Hruby VJ. Enantioselective synthesis of anti-β-substituted γ,δ- unsaturated amino acids: A highly selective asymmetric Thio-Claisen rearrangement (Organic Letters (2008) 10) Organic Letters. 11: 497. DOI: 10.1021/ol8027913 |
1 |
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| 2008 |
Josan JS, Vagner J, Handl HL, Sankaranarayanan R, Gillies RJ, Hruby VJ. Solid-Phase Synthesis of Heterobivalent Ligands Targeted to Melanocortin and Cholecystokinin Receptors. International Journal of Peptide Research and Therapeutics. 14: 293-300. PMID 19714261 DOI: 10.1007/s10989-008-9150-3 |
1 |
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| 2008 |
Min BJ, Gu X, Yamamoto T, Petrov RR, Qu H, Lee YS, Hruby VJ. Synthesis of a novel benzyl-octahydropyrazino[1,2-a]pyrimidin-6-one derivative as a convenient internal bicyclic peptidomimetic. Tetrahedron Letters. 49: 2316-2319. PMID 19340283 DOI: 10.1016/j.tetlet.2008.01.137 |
1 |
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| 2008 |
Yamamoto T, Nair P, Jacobsen NE, Davis P, Ma SW, Navratilova E, Moye S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 6334-47. PMID 18821747 DOI: 10.1021/jm800389v |
1 |
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| 2008 |
Balagurunathan Y, Morse DL, Hostetter G, Shanmugam V, Stafford P, Shack S, Pearson J, Trissal M, Demeure MJ, Von Hoff DD, Hruby VJ, Gillies RJ, Han H. Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer. Molecular Cancer Therapeutics. 7: 3071-80. PMID 18765825 DOI: 10.1158/1535-7163.MCT-08-0402 |
1 |
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| 2008 |
Liu Z, Qu H, Gu X, Min BJ, Nichol GS, Nyberg J, Hruby VJ. Enantioselective synthesis of anti-beta-substituted gamma,delta-unsaturated amino acids: a highly selective asymmetric thio-Claisen rearrangement. Organic Letters. 10: 4105-8. PMID 18702500 DOI: 10.1021/ol801657q |
1 |
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| 2008 |
Agnes RS, Ying J, Kövér KE, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Peptides. 29: 1413-23. PMID 18502541 DOI: 10.1016/j.peptides.2008.03.022 |
1 |
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| 2008 |
Vagner J, Qu H, Hruby VJ. Peptidomimetics, a synthetic tool of drug discovery. Current Opinion in Chemical Biology. 12: 292-6. PMID 18423417 DOI: 10.1016/j.cbpa.2008.03.009 |
1 |
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| 2008 |
Grieco P, Cai M, Liu L, Mayorov A, Chandler K, Trivedi D, Lin G, Campiglia P, Novellino E, Hruby VJ. Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists. Journal of Medicinal Chemistry. 51: 2701-7. PMID 18412316 DOI: 10.1021/jm701181n |
1 |
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| 2008 |
Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 1369-76. PMID 18266313 DOI: 10.1021/jm070332f |
1 |
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| 2008 |
Vagner J, Xu L, Handl HL, Josan JS, Morse DL, Mash EA, Gillies RJ, Hruby VJ. Heterobivalent ligands crosslink multiple cell-surface receptors: the human melanocortin-4 and delta-opioid receptors. Angewandte Chemie (International Ed. in English). 47: 1685-8. PMID 18205159 DOI: 10.1002/anie.200702770 |
1 |
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| 2008 |
Georgieva T, Devanathan S, Stropova D, Park CK, Salamon Z, Tollin G, Hruby VJ, Roeske WR, Yamamura HI, Varga E. Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling. European Journal of Pharmacology. 581: 19-29. PMID 18162180 DOI: 10.1016/j.ejphar.2007.11.053 |
1 |
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| 2008 |
Mayorov AV, Cai M, Palmer ES, Dedek MM, Cain JP, Van Scoy AR, Tan B, Vagner J, Trivedi D, Hruby VJ. Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor. Journal of Medicinal Chemistry. 51: 187-95. PMID 18088090 DOI: 10.1021/jm070461w |
1 |
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| 2008 |
Sutton GM, Josephine Babin M, Gu X, Hruby VJ, Butler AA. A derivative of the melanocortin receptor antagonist SHU9119 (PG932) increases food intake when administered peripherally. Peptides. 29: 104-11. PMID 18054119 DOI: 10.1016/j.peptides.2007.10.014 |
1 |
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| 2008 |
Lee YS, Agnes RS, Cain JP, Kulkarni V, Cai M, Salibay C, Ciano K, Petrov R, Mayorov A, Vagner J, Trivedi D, Davis P, Ma SW, Lai J, Porreca F, ... ... Hruby VJ, et al. Opioid and melanocortin receptors: do they have overlapping pharmacophores? Biopolymers. 90: 433-8. PMID 17657709 DOI: 10.1002/bip.20814 |
1 |
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| 2008 |
Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. New paradigms and tools in drug design for pain and addiction Drug Addiction: From Basic Research to Therapy. 477-494. DOI: 10.1007/978-0-387-76678-2_28 |
1 |
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| 2008 |
Hadley ME, Heward CB, Hruby VJ, Sawyer TK, Yang YCS. Biological Actions of Melanocyte-Stimulating Hormone Peptides of the Pars Intermedia. 244-262. DOI: 10.1002/9780470720646.ch14 |
1 |
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| 2007 |
Lee YS, Petrov R, Park CK, Ma SW, Davis P, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. Journal of Medicinal Chemistry. 50: 5528-32. PMID 17927164 DOI: 10.1021/jm061465o |
1 |
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| 2007 |
Hruby VJ, Tollin G. Plasmon-waveguide resonance (PWR) spectroscopy for directly viewing rates of GPCR/G-protein interactions and quantifying affinities. Current Opinion in Pharmacology. 7: 507-14. PMID 17869585 DOI: 10.1016/j.coph.2007.08.001 |
1 |
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| 2007 |
Qu H, Gu X, Liu Z, Min BJ, Hruby VJ. Asymmetric Eschenmoser-Claisen rearrangement for anti-beta-substituted gamma,delta-unsaturated amino acids. Organic Letters. 9: 3997-4000. PMID 17760455 DOI: 10.1021/ol701704h |
1 |
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| 2007 |
Handl HL, Sankaranarayanan R, Josan JS, Vagner J, Mash EA, Gillies RJ, Hruby VJ. Synthesis and evaluation of bivalent NDP-alpha-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R). Bioconjugate Chemistry. 18: 1101-9. PMID 17591746 DOI: 10.1021/bc0603642 |
1 |
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| 2007 |
Hruby VJ. Professor Mac E. Hadley: creative scientist, superb teacher, dynamic collaborator and wonderful friend. General and Comparative Endocrinology. 151: 358-60. PMID 17590901 DOI: 10.1016/j.ygcen.2007.02.033 |
1 |
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| 2007 |
King SH, Mayorov AV, Balse-Srinivasan P, Hruby VJ, Vanderah TW, Wessells H. Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry. 7: 1098-1106. PMID 17584130 |
1 |
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| 2007 |
Hruby VJ, Cai M, Cain JP, Mayorov AV, Dedek MM, Trivedi D. Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor. Current Topics in Medicinal Chemistry. 7: 1107-19. PMID 17584128 DOI: 10.2174/156802607780906654 |
1 |
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| 2007 |
Mollica A, Guardiani G, Davis P, Ma SW, Porreca F, Lai J, Mannina L, Sobolev AP, Hruby VJ. Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. Journal of Medicinal Chemistry. 50: 3138-42. PMID 17539621 DOI: 10.1021/jm061048b |
1 |
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| 2007 |
Yamamoto T, Nair P, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Vanderah TW, Yamamura HI, Porreca F, Hruby VJ. Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists. Journal of Medicinal Chemistry. 50: 2779-86. PMID 17516639 DOI: 10.1021/jm061369n |
1 |
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| 2007 |
Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 28: 1191-6. PMID 17482720 DOI: 10.1016/j.peptides.2007.02.012 |
1 |
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| 2007 |
Jagadish B, Sankaranarayanan R, Xu L, Richards R, Vagner J, Hruby VJ, Gillies RJ, Mash EA. Squalene-derived flexible linkers for bioactive peptides. Bioorganic & Medicinal Chemistry Letters. 17: 3310-3. PMID 17448660 DOI: 10.1016/j.bmcl.2007.04.001 |
1 |
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| 2007 |
Zhou M, Nakatani E, Gronenberg LS, Tokimoto T, Wirth MJ, Hruby VJ, Roberts A, Lynch RM, Ghosh I. Peptide-labeled quantum dots for imaging GPCRs in whole cells and as single molecules. Bioconjugate Chemistry. 18: 323-32. PMID 17373766 DOI: 10.1021/bc0601929 |
1 |
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| 2007 |
Lee YS, Nyberg J, Moye S, Agnes RS, Davis P, Ma SW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors. Bioorganic & Medicinal Chemistry Letters. 17: 2161-5. PMID 17329100 DOI: 10.1016/j.bmcl.2007.01.114 |
1 |
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| 2007 |
Navratilova E, Waite S, Stropova D, Eaton MC, Alves ID, Hruby VJ, Roeske WR, Yamamura HI, Varga EV. Quantitative evaluation of human delta opioid receptor desensitization using the operational model of drug action. Molecular Pharmacology. 71: 1416-26. PMID 17322005 DOI: 10.1124/mol.106.030023 |
1 |
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| 2007 |
Ballet S, Mayorov AV, Cai M, Tymecka D, Chandler KB, Palmer ES, Rompaey KV, Misicka A, Tourwé D, Hruby VJ. Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold. Bioorganic & Medicinal Chemistry Letters. 17: 2492-8. PMID 17314042 DOI: 10.1016/j.bmcl.2007.02.020 |
1 |
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| 2007 |
Bowen ME, Monguchi Y, Sankaranarayanan R, Vagner J, Begay LJ, Xu L, Jagadish B, Hruby VJ, Gillies RJ, Mash EA. Design, synthesis, and validation of a branched flexible linker for bioactive peptides. The Journal of Organic Chemistry. 72: 1675-80. PMID 17279799 DOI: 10.1021/jo062276g |
1 |
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| 2007 |
Lee YS, Agnes RS, Davis P, Ma SW, Badghisi H, Lai J, Porreca F, Hruby VJ. Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. Journal of Medicinal Chemistry. 50: 165-8. PMID 17201419 DOI: 10.1021/jm061268p |
1 |
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| 2007 |
Shinoda K, Hruby VJ, Porreca F. Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors. Neuroscience Letters. 411: 143-6. PMID 17110034 DOI: 10.1016/j.neulet.2006.10.027 |
1 |
|
| 2006 |
Hruby VJ, Vagner J. High throughput synthesis of peptides and peptidomimetics. Chimica Oggi. 24: 18-21. PMID 18618009 |
1 |
|
| 2006 |
Qu H, Carducci MD, Nichol GS, Hruby VJ. (1R,2S)-Benzyl N-[3-(diisopropylaminocarbonyl)-2-phenylprop-3-enyl]carbamate. Acta Crystallographica. Section E, Structure Reports Online. 62: o3921-o3922. PMID 17710225 DOI: 10.1107/S1600536806032041 |
1 |
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| 2006 |
Petrov RR, Vardanyan RS, Nichol GS, Carducci MD, Ma SW, Lai JY, Hruby VJ. 4-{N-[2-(1,3-Dioxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl]anilino}-1-phenethylpiperidinium chloride methanol disolvate. Acta Crystallographica. Section E, Structure Reports Online. 62: o2815-o2816. PMID 17268579 DOI: 10.1107/S1600536806021817 |
1 |
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| 2006 |
Carducci MD, Gu X, Cole JR, Hruby VJ. [N-({(R)-2-[(N-Benzylprolyl)amino]phenyl}-phenylmethylene)-2(S)-(pent-4-enyl)-glycinato]nickel(II). Acta Crystallographica. Section E, Structure Reports Online. 62: m1219-m1220. PMID 17268578 DOI: 10.1107/S160053680601244X |
1 |
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| 2006 |
Ndungu JM, Cain JP, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides. Tetrahedron Letters. 47: 2233-2236. PMID 17203138 DOI: 10.1016/j.tetlet.2006.01.096 |
1 |
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| 2006 |
Ying J, Gu X, Cai M, Dedek M, Vagner J, Trivedi DB, Hruby VJ. Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor. Journal of Medicinal Chemistry. 49: 6888-96. PMID 17154518 DOI: 10.1021/jm060768f |
1 |
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| 2006 |
Cai M, Varga EV, Stankova M, Mayorov A, Perry JW, Yamamura HI, Trivedi D, Hruby VJ. Cell signaling and trafficking of human melanocortin receptors in real time using two-photon fluorescence and confocal laser microscopy: differentiation of agonists and antagonists. Chemical Biology & Drug Design. 68: 183-93. PMID 17105482 DOI: 10.1111/j.1747-0285.2006.00432.x |
1 |
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| 2006 |
Vagner J, Handl HL, Monguchi Y, Jana U, Begay LJ, Mash EA, Hruby VJ, Gillies RJ. Rigid linkers for bioactive peptides. Bioconjugate Chemistry. 17: 1545-50. PMID 17105235 DOI: 10.1021/bc060154p |
1 |
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| 2006 |
Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. New paradigms and tools in drug design for pain and addiction. The Aaps Journal. 8: E450-60. PMID 17025262 DOI: 10.1208/aapsj080353 |
1 |
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| 2006 |
Qu H, Gu X, Min BJ, Liu Z, Hruby VJ. Synthesis of Anti-beta-substituted gamma,delta-unsaturated amino acids via Eschenmoser-Claisen rearrangement. Organic Letters. 8: 4215-8. PMID 16956190 DOI: 10.1021/ol061414l |
1 |
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| 2006 |
Cain JP, Mayorov AV, Cai M, Wang H, Tan B, Chandler K, Lee Y, Petrov RR, Trivedi D, Hruby VJ. Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 16: 5462-7. PMID 16931008 DOI: 10.1016/j.bmcl.2006.07.015 |
1 |
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| 2006 |
Hen G, Yosefi S, Simchaev V, Shinder D, Hruby VJ, Friedman-Einat M. The melanocortin circuit in obese and lean strains of chicks. The Journal of Endocrinology. 190: 527-35. PMID 16899585 DOI: 10.1677/joe.1.06783 |
1 |
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| 2006 |
Petrov RR, Vardanyan RS, Lee YS, Ma SW, Davis P, Begay LJ, Lai JY, Porreca F, Hruby VJ. Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity. Bioorganic & Medicinal Chemistry Letters. 16: 4946-50. PMID 16828552 DOI: 10.1016/j.bmcl.2006.06.040 |
1 |
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| 2006 |
Mayorov AV, Han SY, Cai M, Hammer MR, Trivedi D, Hruby VJ. Effects of macrocycle size and rigidity on melanocortin receptor-1 and -5 selectivity in cyclic lactam alpha-melanocyte-stimulating hormone analogs. Chemical Biology & Drug Design. 67: 329-35. PMID 16784457 DOI: 10.1111/j.1747-0285.2006.00383.x |
1 |
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| 2006 |
Agnes RS, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Journal of Medicinal Chemistry. 49: 2868-75. PMID 16686530 DOI: 10.1021/jm050921q |
1 |
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| 2006 |
Alves ID, Delaroche D, Mouillac B, Salamon Z, Tollin G, Hruby VJ, Lavielle S, Sagan S. The two NK-1 binding sites correspond to distinct, independent, and non-interconvertible receptor conformational states as confirmed by plasmon-waveguide resonance spectroscopy. Biochemistry. 45: 5309-18. PMID 16618119 DOI: 10.1021/bi052586d |
1 |
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| 2006 |
Mayorov AV, Cai M, Chandler KB, Petrov RR, Van Scoy AR, Yu Z, Tanaka DK, Trivedi D, Hruby VJ. Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. Journal of Medicinal Chemistry. 49: 1946-52. PMID 16539382 DOI: 10.1021/jm0510326 |
1 |
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| 2006 |
Lee YS, Agnes RS, Badghisi H, Davis P, Ma SW, Lai J, Porreca F, Hruby VJ. Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. Journal of Medicinal Chemistry. 49: 1773-80. PMID 16509592 DOI: 10.1021/jm050851n |
1 |
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| 2006 |
Grieco P, Cai M, Mayorov AV, Trivedi D, Hruby VJ. Structure-activity studies of new melanocortin peptides containing an aromatic amino acid at the N-terminal position. Peptides. 27: 472-81. PMID 16303211 DOI: 10.1016/j.peptides.2005.01.032 |
1 |
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| 2006 |
Mollica A, Davis P, Ma SW, Porreca F, Lai J, Hruby VJ. Synthesis and biological activity of the first cyclic biphalin analogues. Bioorganic & Medicinal Chemistry Letters. 16: 367-72. PMID 16275086 DOI: 10.1016/j.bmcl.2005.09.080 |
1 |
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| 2006 |
Vardanyan RS, Hruby VJ. Synthesis of Essential Drugs Synthesis of Essential Drugs. |
1 |
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| 2005 |
Vardanyan RS, Hruby VJ, Danagulyan GG, Mkrtchyan AD. Isomerization/Recyclization of some 5-Ethoxycarbonyl-pyrimidines. Journal of Heterocyclic Chemistry. 42: 557-562. PMID 16467919 |
1 |
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| 2005 |
Vessey KA, Lencses KA, Rushforth DA, Hruby VJ, Stell WK. Glucagon receptor agonists and antagonists affect the growth of the chick eye: a role for glucagonergic regulation of emmetropization? Investigative Ophthalmology & Visual Science. 46: 3922-31. PMID 16249465 DOI: 10.1167/iovs.04-1026 |
1 |
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| 2005 |
Soloshonok VA, Cai C, Yamada T, Ueki H, Ohfune Y, Hruby VJ. Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographically controlled stereoselectivity. Journal of the American Chemical Society. 127: 15296-303. PMID 16248672 DOI: 10.1021/ja0535561 |
1 |
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| 2005 |
Smith EA, Coym JW, Cowell SM, Tokimoto T, Hruby VJ, Yamamura HI, Wirth MJ. Lipid bilayers on polyacrylamide brushes for inclusion of membrane proteins. Langmuir : the Acs Journal of Surfaces and Colloids. 21: 9644-50. PMID 16207048 DOI: 10.1021/la051116h |
1 |
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| 2005 |
Liu J, Ying J, Chow VT, Hruby VJ, Satyanarayanajois SD. Structure-activity studies of peptides from the "hot-spot" region of human CD2 protein: development of peptides for immunomodulation. Journal of Medicinal Chemistry. 48: 6236-49. PMID 16190751 DOI: 10.1021/jm0503547 |
1 |
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| 2005 |
Alves ID, Park CK, Hruby VJ. Plasmon resonance methods in GPCR signaling and other membrane events. Current Protein & Peptide Science. 6: 293-312. PMID 16101432 DOI: 10.2174/1389203054546352 |
1 |
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| 2005 |
Fung S, Hruby VJ. Design of cyclic and other templates for potent and selective peptide alpha-MSH analogues. Current Opinion in Chemical Biology. 9: 352-8. PMID 16023401 DOI: 10.1016/j.cbpa.2005.06.010 |
1 |
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| 2005 |
Handl HL, Vagner J, Yamamura HI, Hruby VJ, Gillies RJ. Development of a lanthanide-based assay for detection of receptor-ligand interactions at the delta-opioid receptor. Analytical Biochemistry. 343: 299-307. PMID 16004955 DOI: 10.1016/j.ab.2005.05.040 |
1 |
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| 2005 |
Alves ID, Salamon Z, Hruby VJ, Tollin G. Ligand modulation of lateral segregation of a G-protein-coupled receptor into lipid microdomains in sphingomyelin/phosphatidylcholine solid-supported bilayers. Biochemistry. 44: 9168-78. PMID 15966741 DOI: 10.1021/bi050207a |
1 |
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| 2005 |
King T, Gardell LR, Wang R, Vardanyan A, Ossipov MH, Malan TP, Vanderah TW, Hunt SP, Hruby VJ, Lai J, Porreca F. Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain. 116: 276-88. PMID 15964684 DOI: 10.1016/j.pain.2005.04.014 |
1 |
|
| 2005 |
Cai M, Mayorov AV, Ying J, Stankova M, Trivedi D, Cabello C, Hruby VJ. Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors. Peptides. 26: 1481-5. PMID 15876475 DOI: 10.1016/j.peptides.2005.03.020 |
1 |
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| 2005 |
Hsu R, Taylor JR, Newton SS, Alvaro JD, Haile C, Han G, Hruby VJ, Nestler EJ, Duman RS. Blockade of melanocortin transmission inhibits cocaine reward. The European Journal of Neuroscience. 21: 2233-42. PMID 15869520 DOI: 10.1111/j.1460-9568.2005.04038.x |
1 |
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| 2005 |
Mollica A, Davis P, Ma SW, Lai J, Porreca F, Hruby VJ. Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers. Bioorganic & Medicinal Chemistry Letters. 15: 2471-5. PMID 15863299 DOI: 10.1016/j.bmcl.2005.03.067 |
1 |
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| 2005 |
Dhanasekaran M, Palian MM, Alves I, Yeomans L, Keyari CM, Davis P, Bilsky EJ, Egleton RD, Yamamura HI, Jacobsen NE, Tollin G, Hruby VJ, Porreca F, Polt R. Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers. Journal of the American Chemical Society. 127: 5435-48. PMID 15826181 DOI: 10.1021/ja0432158 |
1 |
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| 2005 |
Subramaniam V, Alves ID, Salgado GF, Lau PW, Wysocki RJ, Salamon Z, Tollin G, Hruby VJ, Brown MF, Saavedra SS. Rhodopsin reconstituted into a planar-supported lipid bilayer retains photoactivity after cross-linking polymerization of lipid monomers. Journal of the American Chemical Society. 127: 5320-1. PMID 15826160 DOI: 10.1021/ja0423973 |
1 |
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| 2005 |
Cai M, Mayorov AV, Cabello C, Stankova M, Trivedi D, Hruby VJ. Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues. Journal of Medicinal Chemistry. 48: 1839-48. PMID 15771429 DOI: 10.1021/jm049579s |
1 |
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| 2005 |
Lin J, Liao S, Hruby VJ. Syntheses of optically pure, conformationally constrained, and highly hydrophobic unusual amino acids: 2-amino-3, 3-diarylpropionic acids. The Journal of Peptide Research : Official Journal of the American Peptide Society. 65: 105-12. PMID 15686541 DOI: 10.1111/j.1399-3011.2004.00194.x |
1 |
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| 2005 |
Gu X, Ying J, Min B, Cain JP, Davis P, Willey P, Navratilova E, Yamamura HI, Porreca F, Hruby VJ. Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues. Biopolymers. 80: 151-63. PMID 15660379 DOI: 10.1002/bip.20208 |
1 |
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| 2005 |
Alves ID, Salgado GF, Salamon Z, Brown MF, Tollin G, Hruby VJ. Phosphatidylethanolamine enhances rhodopsin photoactivation and transducin binding in a solid supported lipid bilayer as determined using plasmon-waveguide resonance spectroscopy. Biophysical Journal. 88: 198-210. PMID 15501933 DOI: 10.1529/biophysj.104.046722 |
1 |
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| 2005 |
Hruby VJ. On the topic of peptide research and drug discovery Journal of Peptide Research. 66: 309-310. DOI: 10.1111/j.1399-3011.2005.00307.x |
1 |
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| 2005 |
Monguchi Y, Vagner J, Handl HL, Jana U, Begay LJ, Hruby VJ, Gillies RJ, Mash EA. Design, synthesis, and validation of rigid linkers for bioactive peptides Tetrahedron Letters. 46: 7589-7592. DOI: 10.1016/j.tetlet.2005.08.151 |
1 |
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| 2005 |
Hruby VJ, Lawson S. Where are the science heroes? [3] (multiple letters) Scientist. 19: 8. |
1 |
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| 2004 |
Handl HL, Vagner J, Han H, Mash E, Hruby VJ, Gillies RJ. Hitting multiple targets with multimeric ligands. Expert Opinion On Therapeutic Targets. 8: 565-86. PMID 15584863 DOI: 10.1517/14728222.8.6.565 |
1 |
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| 2004 |
Cowell SM, Lee YS, Cain JP, Hruby VJ. Exploring Ramachandran and chi space: conformationally constrained amino acids and peptides in the design of bioactive polypeptide ligands. Current Medicinal Chemistry. 11: 2785-98. PMID 15544476 |
1 |
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| 2004 |
Ossipov MH, Lai J, King T, Vanderah TW, Malan TP, Hruby VJ, Porreca F. Antinociceptive and nociceptive actions of opioids. Journal of Neurobiology. 61: 126-48. PMID 15362157 DOI: 10.1002/neu.20091 |
1 |
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| 2004 |
Gu X, Ying J, Agnes RS, Navratilova E, Davis P, Stahl G, Porreca F, Yamamura HI, Hruby VJ. Novel design of bicyclic beta-turn dipeptides on solid-phase supports and synthesis of [3.3.0]-Bicyclo([2,3])-leu-enkephalin analogues. Organic Letters. 6: 3285-8. PMID 15355033 DOI: 10.1021/ol0488183 |
1 |
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| 2004 |
Alves ID, Ciano KA, Boguslavski V, Varga E, Salamon Z, Yamamura HI, Hruby VJ, Tollin G. Selectivity, cooperativity, and reciprocity in the interactions between the delta-opioid receptor, its ligands, and G-proteins. The Journal of Biological Chemistry. 279: 44673-82. PMID 15317820 DOI: 10.1074/jbc.M404713200 |
1 |
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| 2004 |
Soloshonok VA, Ueki H, Tiwari R, Cai C, Hruby VJ. Virtually complete control of simple and face diastereoselectivity in the Michael addition reactions between achiral equivalents of a nucleophilic glycine and (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: practical method for preparation of beta-substituted pyroglutamic acids and prolines. The Journal of Organic Chemistry. 69: 4984-90. PMID 15255725 DOI: 10.1021/jo0495438 |
1 |
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| 2004 |
Handl HL, Vagner J, Yamamura HI, Hruby VJ, Gillies RJ. Lanthanide-based time-resolved fluorescence of in cyto ligand-receptor interactions. Analytical Biochemistry. 330: 242-50. PMID 15203329 DOI: 10.1016/j.ab.2004.04.012 |
1 |
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| 2004 |
Cai M, Stankova M, Pond SJ, Mayorov AV, Perry JW, Yamamura HI, Trivedi D, Hruby VJ. Real time differentiation of G-protein coupled receptor (GPCR) agonist and antagonist by two photon fluorescence laser microscopy. Journal of the American Chemical Society. 126: 7160-1. PMID 15186137 DOI: 10.1021/ja049473m |
1 |
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| 2004 |
Elmagbari NO, Egleton RD, Palian MM, Lowery JJ, Schmid WR, Davis P, Navratilova E, Dhanasekaran M, Keyari CM, Yamamura HI, Porreca F, Hruby VJ, Polt R, Bilsky EJ. Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides. The Journal of Pharmacology and Experimental Therapeutics. 311: 290-7. PMID 15166257 DOI: 10.1124/jpet.104.069393 |
1 |
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| 2004 |
Lipkowski AW, Carr DB, Hruby VJ, Yoshikawa M. Is RNA-laden p24 capsid protein a vector for HIV? Medical Hypotheses. 62: 919-21. PMID 15142648 DOI: 10.1016/j.mehy.2003.12.035 |
1 |
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| 2004 |
Alves I, Cowell S, Lee YS, Tang X, Davis P, Porreca F, Hruby VJ. A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid, CCK, and melanotropin ligands. Biochemical and Biophysical Research Communications. 318: 335-40. PMID 15120606 DOI: 10.1016/j.bbrc.2004.04.033 |
1 |
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| 2004 |
Alves ID, Cowell SM, Salamon Z, Devanathan S, Tollin G, Hruby VJ. Different structural states of the proteolipid membrane are produced by ligand binding to the human delta-opioid receptor as shown by plasmon-waveguide resonance spectroscopy. Molecular Pharmacology. 65: 1248-57. PMID 15102953 DOI: 10.1124/mol.65.5.1248 |
1 |
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| 2004 |
Cai M, Cai C, Mayorov AV, Xiong C, Cabello CM, Soloshonok VA, Swift JR, Trivedi D, Hruby VJ. Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity. The Journal of Peptide Research : Official Journal of the American Peptide Society. 63: 116-31. PMID 15009533 DOI: 10.1111/j.1399-3011.2003.00105.x |
1 |
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| 2004 |
Han G, Haskell-Luevano C, Kendall L, Bonner G, Hadley ME, Cone RD, Hruby VJ. De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach. Journal of Medicinal Chemistry. 47: 1514-26. PMID 14998337 DOI: 10.1021/jm030452x |
1 |
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| 2004 |
Vagner J, Handl HL, Gillies RJ, Hruby VJ. Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of alpha-MSH. Bioorganic & Medicinal Chemistry Letters. 14: 211-5. PMID 14684330 DOI: 10.1016/j.bmcl.2003.09.079 |
1 |
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| 2004 |
Cai C, Yamada T, Tiwari R, Hruby VJ, Soloshonok VA. Application of (S)- and (R)-methyl pyroglutamates as inexpensive, yet highly efficient chiral auxiliaries in the asymmetric Michael addition reactions Tetrahedron Letters. 45: 6855-6858. DOI: 10.1016/j.tetlet.2004.07.096 |
1 |
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| 2004 |
Gu X, Ndungu JM, Qiu W, Ying J, Carducci MD, Wooden H, Hruby VJ. Large scale enantiomeric synthesis, purification, and characterization of ω-unsaturated amino acids via a Gly-Ni(II)-BPB-complex Tetrahedron. 60: 8233-8243. DOI: 10.1016/j.tet.2004.06.087 |
1 |
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| 2003 |
Ying J, Kövér KE, Gu X, Han G, Trivedi DB, Kavarana MJ, Hruby VJ. Solution structures of cyclic melanocortin agonists and antagonists by NMR. Biopolymers. 71: 696-716. PMID 14991679 DOI: 10.1002/bip.10596 |
0.88 |
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| 2003 |
Cowell SM, Gu X, Vagner J, Hruby VJ. Intelligent design in combinatorial chemistry: use of designed peptide libraries to explore secondary and tertiary structures in peptides and proteins. Methods in Enzymology. 369: 288-97. PMID 14722960 DOI: 10.1016/S0076-6879(03)69016-6 |
1 |
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| 2003 |
Tollin G, Salamon Z, Hruby VJ. Techniques: plasmon-waveguide resonance (PWR) spectroscopy as a tool to study ligand-GPCR interactions. Trends in Pharmacological Sciences. 24: 655-9. PMID 14654307 DOI: 10.1016/j.tips.2003.10.010 |
0.56 |
|
| 2003 |
Balse-Srinivasan P, Grieco P, Cai M, Trivedi D, Hruby VJ. Structure-activity relationships of gamma-MSH analogues at the human melanocortin MC3, MC4, and MC5 receptors. Discovery of highly selective hMC3R, hMC4R, and hMC5R analogues. Journal of Medicinal Chemistry. 46: 4965-73. PMID 14584947 DOI: 10.1021/jm030119t |
1 |
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| 2003 |
Tollin G, Salamon Z, Cowell S, Hruby VJ. Plasmon-waveguide resonance spectroscopy: a new tool for investigating signal transduction by G-protein coupled receptors. Life Sciences. 73: 3307-11. PMID 14572873 DOI: 10.1016/j.lfs.2003.07.001 |
1 |
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| 2003 |
Grieco P, Balse-Srinivasan P, Han G, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ. Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. The Journal of Peptide Research : Official Journal of the American Peptide Society. 62: 199-206. PMID 14531843 |
0.84 |
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| 2003 |
Alves ID, Salamon Z, Varga E, Yamamura HI, Tollin G, Hruby VJ. Direct observation of G-protein binding to the human delta-opioid receptor using plasmon-waveguide resonance spectroscopy. The Journal of Biological Chemistry. 278: 48890-7. PMID 14522991 DOI: 10.1074/jbc.M306866200 |
1 |
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| 2003 |
Hruby VJ. Peptide science: exploring the use of chemical principles and interdisciplinary collaboration for understanding life processes. Journal of Medicinal Chemistry. 46: 4215-31. PMID 13678399 DOI: 10.1021/jm0303103 |
1 |
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| 2003 |
Zhang J, Xiong C, Ying J, Wang W, Hruby VJ. Stereoselective synthesis of novel dipeptide beta-turn mimetics targeting melanocortin peptide receptors. Organic Letters. 5: 3115-8. PMID 12916995 DOI: 10.1021/ol0351347 |
0.88 |
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| 2003 |
Balse-Srinivasan P, Grieco P, Cai M, Trivedi D, Hruby VJ. Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R. Journal of Medicinal Chemistry. 46: 3728-33. PMID 12904077 DOI: 10.1021/jm030111j |
1 |
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| 2003 |
Xiong C, Zhang J, Davis P, Wang W, Ying J, Porreca F, Hruby VJ. Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted beta-turn bicyclic dipeptide mimetics. Chemical Communications (Cambridge, England). 1598-9. PMID 12868772 |
1 |
|
| 2003 |
Wessells H, Hruby VJ, Hackett J, Han G, Balse-Srinivasan P, Vanderah TW. MT-II induces penile erection via brain and spinal mechanisms. Annals of the New York Academy of Sciences. 994: 90-5. PMID 12851302 |
1 |
|
| 2003 |
Hruby VJ, Cai M, Grieco P, Han G, Kavarana M, Trivedi D. Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors. Annals of the New York Academy of Sciences. 994: 12-20. PMID 12851293 |
1 |
|
| 2003 |
Hruby VJ, Agnes RS, Davis P, Ma SW, Lee YS, Vanderah TW, Lai J, Porreca F. Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain. Life Sciences. 73: 699-704. PMID 12801591 DOI: 10.1016/S0024-3205(03)00390-4 |
1 |
|
| 2003 |
Boguslavsky V, Hruby VJ, O'Brien DF, Misicka A, Lipkowski AW. Effect of peptide conformation on membrane permeability. The Journal of Peptide Research : Official Journal of the American Peptide Society. 61: 287-97. PMID 12753376 |
0.32 |
|
| 2003 |
Wessells H, Hruby VJ, Hackett J, Han G, Balse-Srinivasan P, Vanderah TW. Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors. Neuroscience. 118: 755-62. PMID 12710982 DOI: 10.1016/S0306-4522(02)00866-7 |
1 |
|
| 2003 |
Gillies RJ, Hruby VJ. Expression-driven reverse engineering of targeted imaging and therapeutic agents. Expert Opinion On Therapeutic Targets. 7: 137-9. PMID 12667092 DOI: 10.1517/14728222.7.2.137 |
1 |
|
| 2003 |
Mogil JS, Wilson SG, Chesler EJ, Rankin AL, Nemmani KV, Lariviere WR, Groce MK, Wallace MR, Kaplan L, Staud R, Ness TJ, Glover TL, Stankova M, Mayorov A, Hruby VJ, et al. The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proceedings of the National Academy of Sciences of the United States of America. 100: 4867-72. PMID 12663858 DOI: 10.1073/pnas.0730053100 |
1 |
|
| 2003 |
Varga EV, Rubenzik MK, Stropova D, Sugiyama M, Grife V, Hruby VJ, Rice KC, Roeske WR, Yamamura HI. Converging protein kinase pathways mediate adenylyl cyclase superactivation upon chronic delta-opioid agonist treatment. The Journal of Pharmacology and Experimental Therapeutics. 306: 109-15. PMID 12660310 DOI: 10.1124/jpet.103.049643 |
1 |
|
| 2003 |
Ying J, Ahn JM, Jacobsen NE, Brown MF, Hruby VJ. NMR solution structure of the glucagon antagonist [desHis1, desPhe6, Glu9]glucagon amide in the presence of perdeuterated dodecylphosphocholine micelles. Biochemistry. 42: 2825-35. PMID 12627948 DOI: 10.1021/bi026629r |
0.96 |
|
| 2003 |
Han G, Quillan JM, Carlson K, Sadée W, Hruby VJ. Design of novel chimeric melanotropin-deltorphin analogues. Discovery of the first potent human melanocortin 1 receptor antagonist. Journal of Medicinal Chemistry. 46: 810-9. PMID 12593660 DOI: 10.1021/jm020355o |
0.84 |
|
| 2003 |
Hosohata K, Varga EV, Alfaro-Lopez J, Tang X, Vanderah TW, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. (2S,3R) beta-methyl-2',6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-L-Tic-OH] is a potent, selective delta-opioid receptor antagonist in mouse brain. The Journal of Pharmacology and Experimental Therapeutics. 304: 683-8. PMID 12538822 DOI: 10.1124/jpet.102.042929 |
1 |
|
| 2003 |
Okura T, Varga EV, Hosohata Y, Navratilova E, Cowell SM, Rice K, Nagase H, Hruby VJ, Roeske WR, Yamamura HI. Agonist-specific down-regulation of the human delta-opioid receptor. European Journal of Pharmacology. 459: 9-16. PMID 12505529 DOI: 10.1016/S0014-2999(02)02823-6 |
1 |
|
| 2002 |
Salamon Z, Hruby VJ, Tollin G, Cowell S. Binding of agonists, antagonists and inverse agonists to the human delta-opioid receptor produces distinctly different conformational states distinguishable by plasmon-waveguide resonance spectroscopy. The Journal of Peptide Research : Official Journal of the American Peptide Society. 60: 322-8. PMID 12464110 DOI: 10.1034/j.1399-3011.2002.21060.x |
1 |
|
| 2002 |
Grieco P, Lavecchia A, Cai M, Trivedi D, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ. Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors. Journal of Medicinal Chemistry. 45: 5287-94. PMID 12431055 DOI: 10.1021/jm0202526 |
1 |
|
| 2002 |
Zhang J, Xiong C, Wang W, Ying J, Hruby VJ. Stereoselective bromination-suzuki cross-coupling of dehydroamino acids to form novel reverse-turn peptidomimetics: substituted unsaturated and saturated indolizidinone amino acids. Organic Letters. 4: 4029-32. PMID 12423078 |
0.88 |
|
| 2002 |
Hruby VJ. Designing peptide receptor agonists and antagonists. Nature Reviews. Drug Discovery. 1: 847-58. PMID 12415245 DOI: 10.1038/nrd939 |
1 |
|
| 2002 |
Wang W, Yang J, Ying J, Xiong C, Zhang J, Cai C, Hruby VJ. Stereoselective synthesis of dipeptide beta-turn mimetics: 7-benzyl and 8-phenyl substituted azabicyclo[4.3.0]nonane amino acid esters. The Journal of Organic Chemistry. 67: 6353-60. PMID 12201753 |
1 |
|
| 2002 |
Kavarana MJ, Trivedi D, Cai M, Ying J, Hammer M, Cabello C, Grieco P, Han G, Hruby VJ. Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors. Journal of Medicinal Chemistry. 45: 2644-50. PMID 12036373 DOI: 10.1021/jm020021z |
1 |
|
| 2002 |
Xiong C, Wang W, Hruby VJ. A general asymmetric synthesis of syn- and anti-beta-substituted cysteine and serine derivatives. The Journal of Organic Chemistry. 67: 3514-7. PMID 12003570 DOI: 10.1021/jo011172x |
1 |
|
| 2002 |
Grieco P, Balse-Srinivasan P, Han G, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ. Synthesis and biological evaluation on hMC3, hMC4 and hMC5 receptors of gamma-MSH analogs substituted with L-alanine. The Journal of Peptide Research : Official Journal of the American Peptide Society. 59: 203-10. PMID 11966977 |
0.84 |
|
| 2002 |
Grieco P, Han G, Weinberg D, Van der Ploeg LH, Hruby VJ. Design and synthesis of highly potent and selective melanotropin analogues of SHU9119 modified at position 6. Biochemical and Biophysical Research Communications. 292: 1075-80. PMID 11944925 DOI: 10.1006/bbrc.2002.6739 |
0.84 |
|
| 2002 |
Moens K, Berger V, Ahn JM, Van Schravendijk C, Hruby VJ, Pipeleers D, Schuit F. Assessment of the role of interstitial glucagon in the acute glucose secretory responsiveness of in situ pancreatic beta-cells. Diabetes. 51: 669-75. PMID 11872665 |
0.96 |
|
| 2002 |
Xiong C, Wang W, Cai C, Hruby VJ. Regioselective and stereoselective nucleophilic ring opening reactions of a phenyl-substituted aziridine: enantioselective synthesis of beta-substituted tryptophan, cysteine, and serine derivatives. The Journal of Organic Chemistry. 67: 1399-402. PMID 11846696 |
1 |
|
| 2002 |
Romanowski M, Zhu X, Kim K, Hruby VJ, O'Brien DF. Interaction of enkephalin peptides with anionic model membranes. Biochimica Et Biophysica Acta. 1558: 45-53. PMID 11750263 DOI: 10.1016/S0005-2736(01)00421-7 |
1 |
|
| 2002 |
Hruby VJ, Qui W, Okayama T, Soloshonok VA. Design of nonpeptides from peptide ligands for peptide receptors. Methods in Enzymology. 343: 91-123. PMID 11665597 DOI: 10.1016/S0076-6879(02)43129-1 |
1 |
|
| 2002 |
Hruby VJ, Agnes RS, Cai C. Design of peptide agonists. Methods in Enzymology. 343: 73-91. PMID 11665596 DOI: 10.1016/S0076-6879(02)43128-X |
1 |
|
| 2002 |
Cowell SM, Balse-Srinivasan PM, Ahn JM, Hruby VJ. Design and synthesis of peptide antagonists and inverse agonists for G protein-coupled receptors. Methods in Enzymology. 343: 49-72. PMID 11665587 DOI: 10.1016/S0076-6879(02)43127-8 |
1 |
|
| 2001 |
Han G, Tamaki M, Hruby VJ. Fast, efficient and selective deprotection of the tert-butoxycarbonyl (Boc) group using HCl/dioxane (4 m). The Journal of Peptide Research : Official Journal of the American Peptide Society. 58: 338-41. PMID 11606219 DOI: 10.1034/j.1399-3011.2001.00935.x |
1 |
|
| 2001 |
Hruby VJ. Vincent duVigneaud 1901-1978: a personal tribute. The Journal of Peptide Research : Official Journal of the American Peptide Society. 58: 191-2. PMID 11576324 DOI: 10.1034/j.1399-3011.2001.00583.x |
1 |
|
| 2001 |
Ahn JM, Gitu PM, Medeiros M, Swift JR, Trivedi D, Hruby VJ. A new approach to search for the bioactive conformation of glucagon: positional cyclization scanning. Journal of Medicinal Chemistry. 44: 3109-16. PMID 11543679 |
0.96 |
|
| 2001 |
Ahn JM, Medeiros M, Trivedi D, Hruby VJ. Development of potent glucagon antagonists: structure-activity relationship study of glycine at position 4. The Journal of Peptide Research : Official Journal of the American Peptide Society. 58: 151-8. PMID 11532074 |
0.96 |
|
| 2001 |
Tamaki M, Han G, Hruby VJ. Practical and efficient synthesis of orthogonally protected constrained 4-guanidinoprolines. The Journal of Organic Chemistry. 66: 1038-42. PMID 11430070 DOI: 10.1021/jo005626m |
1 |
|
| 2001 |
Soloshonok VA, Tang X, Hruby VJ, Van Meervelt L. Asymmetric synthesis of alpha,beta-dialkyl-alpha-phenylalanines via direct alkylation of a chiral alanine derivative with racemic alpha-alkylbenzyl bromides. A case of high enantiomer differentiation at room temperature. Organic Letters. 3: 341-3. PMID 11428009 |
0.72 |
|
| 2001 |
Hosohata Y, Varga EV, Stropova D, Li X, Knapp RJ, Hruby VJ, Rice KC, Nagase H, Roeske WR, Yamamura HI. Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation. Life Sciences. 68: 2233-42. PMID 11358332 DOI: 10.1016/S0024-3205(01)01011-6 |
1 |
|
| 2001 |
Hruby VJ. Design in topographical space of peptide and peptidomimetic ligands that affect behavior. A chemist's glimpse at the mind--body problem. Accounts of Chemical Research. 34: 389-97. PMID 11352717 DOI: 10.1021/ar990063q |
1 |
|
| 2001 |
Tamaki M, Han G, Hruby VJ. Synthesis of 4-cis-phenyl-L-proline via hydrogenolysis. The Journal of Organic Chemistry. 66: 3593-6. PMID 11348150 DOI: 10.1021/jo005625u |
1 |
|
| 2001 |
Cai C, Soloshonok VA, Hruby VJ. Michael addition reactions between chiral Ni(II) complex of glycine and 3-(trans-enoyl)oxazolidin-2-ones. A case of electron donor-acceptor attractive interaction-controlled face diastereoselectivity. The Journal of Organic Chemistry. 66: 1339-50. PMID 11312965 DOI: 10.1021/jo0014865 |
1 |
|
| 2001 |
Ahn JM, Medeiros M, Trivedi D, Hruby VJ. Development of potent truncated glucagon antagonists. Journal of Medicinal Chemistry. 44: 1372-9. PMID 11311060 |
0.96 |
|
| 2001 |
Grieco P, Gitu PM, Hruby VJ. Preparation of 'side-chain-to-side-chain' cyclic peptides by Allyl and Alloc strategy: potential for library synthesis. The Journal of Peptide Research : Official Journal of the American Peptide Society. 57: 250-6. PMID 11298927 DOI: 10.1111/j.1399-3011.2001.00816.x |
1 |
|
| 2001 |
Mitchell SA, Pratt MR, Hruby VJ, Polt R. Solid-phase synthesis of O-linked glycopeptide analogues of enkephalin Journal of Organic Chemistry. 66: 2327-2342. PMID 11281773 DOI: 10.1021/jo005712m |
1 |
|
| 2001 |
Wang Z, Gardell LR, Ossipov MH, Vanderah TW, Brennan MB, Hochgeschwender U, Hruby VJ, Malan TP, Lai J, Porreca F. Pronociceptive actions of dynorphin maintain chronic neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1779-86. PMID 11222667 |
1 |
|
| 2001 |
Lipkowski AW, Misicka A, Hosohata K, Davis P, Yamamura HI, Porreca F, Hruby VJ. Biological properties of Phe(o)-opioid peptide analogues. Life Sciences. 68: 969-72. PMID 11213367 DOI: 10.1016/S0024-3205(00)00993-0 |
1 |
|
| 2000 |
Grieco P, Balse PM, Weinberg D, MacNeil T, Hruby VJ. D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity. Journal of Medicinal Chemistry. 43: 4998-5002. PMID 11150170 |
0.84 |
|
| 2000 |
Salamon Z, Cowell S, Varga E, Yamamura HI, Hruby VJ, Tollin G. Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions. Biophysical Journal. 79: 2463-74. PMID 11053123 DOI: 10.1016/S0006-3495(00)76489-7 |
1 |
|
| 2000 |
Soloshonok VA, Cai C, Hruby VJ, Van Meervelt L, Yamazaki T. Rational design of highly diastereoselective, organic base-catalyzed, room-temperature Michael addition reactions. The Journal of Organic Chemistry. 65: 6688-96. PMID 11052120 |
1 |
|
| 2000 |
Egleton RD, Mitchell SA, Huber JD, Janders J, Stropova D, Polt R, Yamamura HI, Hruby VJ, Davis TP. Improved bioavailability to the brain of glycosylated Met-enkephalin analogs. Brain Research. 881: 37-46. PMID 11033091 DOI: 10.1016/S0006-8993(00)02794-3 |
1 |
|
| 2000 |
Wessells H, Gralnek D, Dorr R, Hruby VJ, Hadley ME, Levine N. Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology. 56: 641-6. PMID 11018622 |
0.68 |
|
| 2000 |
Balse PM, Kim HJ, Han G, Hruby VJ. Evaluation of new base-labile 2-(4-nitrophenylsulfonyl) ethoxycarbonyl (Nsc)-amino acids for solid-phase peptide synthesis. The Journal of Peptide Research : Official Journal of the American Peptide Society. 56: 70-9. PMID 10961541 |
0.84 |
|
| 2000 |
Soloshonok VA, Cai C, Hruby VJ. A Practical Asymmetric Synthesis of Enantiomerically Pure 3-Substituted Pyroglutamic Acids and Related Compounds This work was supported by grants from the U.S. Public Health Service (Grant DK 17420) and the National Institute of Drug Abuse (DA 06284 and DA 04248). The views expressed are those of the authors and not necessarily those of the USPHS. Angewandte Chemie (International Ed. in English). 39: 2172-2175. PMID 10941052 DOI: 10.1002/1521-3773(20000616)39:12<2172::AID-ANIE2172>3.0.CO;2-0 |
1 |
|
| 2000 |
Ko MC, Willmont KJ, Burritt A, Hruby VJ, Woods JH. Local inhibitory effects of dynorphin A-(1-17) on capsaicin-induced thermal allodynia in rhesus monkeys. European Journal of Pharmacology. 402: 69-76. PMID 10940359 DOI: 10.1016/S0014-2999(00)00503-3 |
1 |
|
| 2000 |
Hruby VJ. Peptide science--whither thou goest? The Journal of Peptide Research : Official Journal of the American Peptide Society. 56: 1-2. PMID 10917451 DOI: 10.1034/j.1399-3011.2000.056001001.x |
1 |
|
| 2000 |
Hruby VJ, Balse PM. Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads. Current Medicinal Chemistry. 7: 945-70. PMID 10911024 |
1 |
|
| 2000 |
Okayama T, Burritt A, Hruby VJ. 4-Alkoxy-2-hydroxybenzaldehyde (AHB): a versatile aldehyde linker for solid-phase synthesis of C-terminal modified peptides and peptidomimetics. Organic Letters. 2: 1787-90. PMID 10891158 |
1 |
|
| 2000 |
Bilsky EJ, Egleton RD, Mitchell SA, Palian MM, Davis P, Huber JD, Jones H, Yamamura HI, Janders J, Davis TP, Porreca F, Hruby VJ, Polt R. Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability. Journal of Medicinal Chemistry. 43: 2586-90. PMID 10891118 DOI: 10.1021/jm000077y |
1 |
|
| 2000 |
Witt KA, Slate CA, Egleton RD, Huber JD, Yamamura HI, Hruby VJ, Davis TP. Assessment of stereoselectivity of trimethylphenylalanine analogues of delta-opioid [D-Pen(2),D-Pen(5)]-enkephalin. Journal of Neurochemistry. 75: 424-35. PMID 10854288 DOI: 10.1046/j.1471-4159.2000.0750424.x |
1 |
|
| 2000 |
Trivedi D, Lin Y, Ahn JM, Siegel M, Mollova NN, Schram KH, Hruby VJ. Design and synthesis of conformationally constrained glucagon analogues. Journal of Medicinal Chemistry. 43: 1714-22. PMID 10794689 |
0.96 |
|
| 2000 |
Shenderovich MD, Liao S, Qian X, Hruby VJ. A three-dimensional model of the delta-opioid pharmacophore: comparative molecular modeling of peptide and nonpeptide ligands. Biopolymers. 53: 565-80. PMID 10766952 DOI: 10.1002/(SICI)1097-0282(200006)53:7<565::AID-BIP4>3.0.CO;2-5 |
0.68 |
|
| 2000 |
Hosohata K, Logan JK, Varga E, Burkey TH, Vanderah TW, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. The role of the G protein gamma(2) subunit in opioid antinociception in mice. European Journal of Pharmacology. 392: R9-R11. PMID 10762674 DOI: 10.1016/S0014-2999(00)00132-1 |
1 |
|
| 2000 |
Soloshonok VA, Cai C, Hruby VJ. (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: ideal Michael acceptors to afford a virtually complete control of simple and face diastereoselectivity in addition reactions with glycine derivatives. Organic Letters. 2: 747-50. PMID 10754676 |
1 |
|
| 2000 |
Bilsky EJ, Qian X, Hruby VJ, Porreca F. Antinociceptive activity of [beta-methyl-2', 6'-dimethyltyrosine(1)]-substituted cyclic [D-Pen(2), D-Pen(5)]Enkephalin and [D-Ala(2),Asp(4)]Deltorphin analogs. The Journal of Pharmacology and Experimental Therapeutics. 293: 151-8. PMID 10734164 |
1 |
|
| 2000 |
Haskell-Luevano C, Lim S, Yuan W, Cone RD, Hruby VJ. Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions. Peptides. 21: 49-57. PMID 10704719 DOI: 10.1016/S0196-9781(99)00167-9 |
1 |
|
| 2000 |
Bonner GG, Davis P, Stropova D, Edsall S, Yamamura HI, Porreca F, Hruby VJ. Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays. Journal of Medicinal Chemistry. 43: 569-80. PMID 10691683 DOI: 10.1021/jm9900218 |
1 |
|
| 2000 |
Hohmann JG, Teal TH, Clifton DK, Davis J, Hruby VJ, Han G, Steiner RA. Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 278: R50-9. PMID 10644621 |
1 |
|
| 1999 |
Hruby VJ, Agnes RS. Conformation-activity relationships of opioid peptides with selective activities at opioid receptors. Biopolymers. 51: 391-410. PMID 10797229 DOI: 10.1002/(SICI)1097-0282(1999)51:6<391::AID-BIP3>3.0.CO;2-X |
1 |
|
| 1998 |
Huang QH, Hruby VJ, Tatro JB. Systemic α-MSH suppresses LPS fever via central melanocortin receptors independently of its suppression of corticosterone and IL-6 release. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 275: R524-R530. PMID 29592179 DOI: 10.1152/ajpregu.1998.275.2.R524 |
0.4 |
|
| 1998 |
Ni XP, Kesterson RA, Sharma SD, Hruby VJ, Cone RD, Wiedemann E, Humphreys MH. Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 274: R931-R938. PMID 29586884 DOI: 10.1152/ajpregu.1998.274.4.R931 |
0.68 |
|
| 1998 |
Sturm NS, Lin Y, Burley SK, Krstenansky JL, Ahn JM, Azizeh BY, Trivedi D, Hruby VJ. Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity. Journal of Medicinal Chemistry. 41: 2693-700. PMID 9667960 DOI: 10.1021/jm980084a |
0.96 |
|
| 1997 |
Hruby VJ, Ahn JM, Liao S. Synthesis of oligopeptide and peptidomimetic libraries. Current Opinion in Chemical Biology. 1: 114-9. PMID 9667835 |
1 |
|
| 1997 |
Hruby VJ, Li G, Haskell-Luevano C, Shenderovich M. Design of peptides, proteins, and peptidomimetics in chi space. Biopolymers. 43: 219-66. PMID 9277134 DOI: 10.1002/(SICI)1097-0282(1997)43:3<219::AID-BIP3>3.0.CO;2-Y |
1 |
|
| 1997 |
Haskell-Luevano C, Toth K, Boteju L, Job C, Castrucci AM, Hadley ME, Hruby VJ. beta-Methylation of the Phe7 and Trp9 melanotropin side chain pharmacophores affects ligand-receptor interactions and prolonged biological activity. Journal of Medicinal Chemistry. 40: 2740-9. PMID 9276019 DOI: 10.1021/jm970018t |
1 |
|
| 1997 |
Azizeh BY, Ahn JM, Caspari R, Shenderovich MD, Trivedi D, Hruby VJ. The role of phenylalanine at position 6 in glucagon's mechanism of biological action: multiple replacement analogues of glucagon. Journal of Medicinal Chemistry. 40: 2555-62. PMID 9258362 DOI: 10.1021/jm960800d |
0.96 |
|
| 1997 |
Haskell-Luevano C, Hendrata S, North C, Sawyer TK, Hadley ME, Hruby VJ, Dickinson C, Gantz I. Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R. Journal of Medicinal Chemistry. 40: 2133-9. PMID 9216831 DOI: 10.1021/jm960840h |
1 |
|
| 1997 |
Haskell-Luevano C, Nikiforovich G, Sharma SD, Yang YK, Dickinson C, Hruby VJ, Gantz I. Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors. Journal of Medicinal Chemistry. 40: 1738-48. PMID 9171884 DOI: 10.1021/jm960845e |
1 |
|
| 1996 |
Haskell-Luevano C, Sawyer TK, Trumpp-Kallmeyer S, Bikker JA, Humblet C, Gantz I, Hruby VJ. Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists. Drug Design and Discovery. 14: 197-211. PMID 9017363 |
1 |
|
| 1996 |
Hadley ME, Hruby VJ, Jiang J, Sharma SD, Fink JL, Haskell-Luevano C, Bentley DL, al-Obeidi F, Sawyer TK. Melanocortin receptors: identification and characterization by melanotropic peptide agonists and antagonists. Pigment Cell Research / Sponsored by the European Society For Pigment Cell Research and the International Pigment Cell Society. 9: 213-34. PMID 9014208 |
1 |
|
| 1996 |
Haskell-Luevano C, Sawyer TK, Hendrata S, North C, Panahinia L, Stum M, Staples DJ, Castrucci AM, Hadley MF, Hruby VJ. Truncation studies of alpha-melanotropin peptides identify tripeptide analogues exhibiting prolonged agonist bioactivity. Peptides. 17: 995-1002. PMID 8899819 DOI: 10.1016/S0196-9781(96)00141-6 |
1 |
|
| 1996 |
Boteju LW, Nikiforovich GV, Haskell-Luevano C, Fang SN, Zalewska T, Stropova D, Yamamura HI, Hruby VJ. The use of topographical constraints in receptor mapping: investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp-(N-Me)Nle-Asp-Phe-NH2 (SNF 9007), a cholecystokinin (26-33) analogue that binds to both CCK-B and delta-opioid receptors. Journal of Medicinal Chemistry. 39: 4120-4. PMID 8831778 DOI: 10.1021/jm960078j |
1 |
|
| 1996 |
Haskell-Luevano C, Miwa H, Dickinson C, Hadley ME, Hruby VJ, Yamada T, Gantz I. Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R. Journal of Medicinal Chemistry. 39: 432-5. PMID 8558511 DOI: 10.1021/jm950407s |
1 |
|
| 1995 |
Haskell-Luevano C, Shenderovich MD, Sharma SD, Nikiforovich GV, Hadley ME, Hruby VJ. Design, synthesis, biology, and conformations of bicyclic alpha-melanotropin analogues. Journal of Medicinal Chemistry. 38: 1736-50. PMID 7752197 |
1 |
|
| 1995 |
Haskell-Luevano C, Boteju LW, Miwa H, Dickinson C, Gantz I, Yamada T, Hadley ME, Hruby VJ. Topographical modification of melanotropin peptide analogues with beta-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities. Journal of Medicinal Chemistry. 38: 4720-9. PMID 7473600 |
1 |
|
| 1994 |
Haskell-Luevano C, Miwa H, Dickinson C, Hruby VJ, Yamada T, Gantz I. Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R. Biochemical and Biophysical Research Communications. 204: 1137-42. PMID 7980588 |
0.68 |
|
| 1975 |
Hruby VJ, Spatola AF, Glasel JA, McKelvy JF. Equilibrium dialysis studies of hormone-neurophysin binding. Annals of the New York Academy of Sciences. 248: 451-7. PMID 235234 |
1 |
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| 1974 |
Spatola AF, Cornelius DA, Hruby VJ, Blomquist AT. Synthesis of oxytocin and related diastereomers deuterated in the half-cystine positions. Comparison of solid-phase and solution methods. The Journal of Organic Chemistry. 39: 2207-12. PMID 4859518 |
1 |
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| 1973 |
Glasel JA, Hruby VJ, McKelvy JF, Spatola AF. Deuteron magnetic resonance studies on the microdynamical behavior of partially deuterated oxytocin with neurophysin. Journal of Molecular Biology. 79: 555-75. PMID 4758065 DOI: 10.1016/0022-2836(73)90406-3 |
0.52 |
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| 1973 |
Brewster AI, Hruby VJ, Spatola AF, Bovey FA. Carbon-13 nuclear magnetic resonance spectroscopy of oxytocin, related oligopeptides, and selected analogs. Biochemistry. 12: 1643-9. PMID 4699993 |
1 |
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| 1973 |
Glasel JA, McKelvy JF, Hruby VJ, Spatola AF. Deuteron magnetic resonance studies of neurohypophysial hormones. Annals of the New York Academy of Sciences. 222: 778-88. PMID 4522444 |
1 |
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| 1969 |
Blomquist AT, Rich DH, Carlson BA, Allen GA, Hruby VJ, Takashima H, Nangeroni LL, Glose P, Du Vigneaud V. Deuterated oxytocins: the synthesis and biological properties of a crystalline analog of deamino-oxytocin deuterated in the 5-asparagine position. Proceedings of the National Academy of Sciences of the United States of America. 64: 263-6. PMID 5263009 |
1 |
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| 1968 |
Blomquist AT, Rich DH, Hruby VJ, Nangeroni LL, Glose P, Du Vigneaud V. Deuterated oxytocins: the synthesis and biological properties of three crystalline analogs of deamino-oxytocin deuterated in the 1-beta-mercaptopropionic acid position. Proceedings of the National Academy of Sciences of the United States of America. 61: 688-92. PMID 5246000 |
1 |
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