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Rizwan Haq, Ph.D. - Publications

Affiliations: 
2003 University of Toronto, Toronto, ON, Canada 
Area:
Neuroscience Biology, Molecular Biology, Animal Physiology Biology
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33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Slyper M, Porter CBM, Ashenberg O, Waldman J, Drokhlyansky E, Wakiro I, Smillie C, Smith-Rosario G, Wu J, Dionne D, Vigneau S, Jané-Valbuena J, Tickle TL, Napolitano S, Su MJ, ... ... Haq R, et al. A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors. Nature Medicine. 26: 792-802. PMID 32405060 DOI: 10.1038/S41591-020-0844-1  0.304
2020 Gstalder C, Liu D, Miao D, Lutterbach B, DeVine AL, Lin C, Shettigar M, Pancholi P, Buchbinder EI, Carter SL, Manos MP, Rojas-Rudilla V, Brennick R, Gjini E, Chen PH, ... ... Haq R, et al. Inactivation of Fbxw7 impairs dsRNA sensing and confers resistance to PD-1 blockade. Cancer Discovery. PMID 32371478 DOI: 10.1158/2159-8290.Cd-19-1416  0.33
2020 Kurppa KJ, Liu Y, To C, Zhang T, Fan M, Vajdi A, Knelson EH, Xie Y, Lim K, Cejas P, Portell A, Lizotte PH, Ficarro SB, Li S, Chen T, ... ... Haq R, et al. Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. Cancer Cell. 37: 104-122.e12. PMID 31935369 DOI: 10.1016/J.Ccell.2019.12.006  0.438
2020 Persky NS, Hernandez D, Do Carmo M, Brenan L, Cohen O, Kitajima S, Nayar U, Walker A, Pantel S, Lee Y, Cordova J, Sathappa M, Zhu C, Hayes TK, Ram P, ... ... Haq R, et al. Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases. Nature Structural & Molecular Biology. 27: 92-104. PMID 31925410 DOI: 10.1038/S41594-019-0358-Z  0.367
2020 Buchbinder EI, Cohen JV, Haq R, Hodi FS, Lawrence DP, Giobbie-Hurder A, Knoerzer D, Sullivan RJ. A phase II study of ERK inhibition by ulixertinib (BVD-523) in metastatic uveal melanoma. Journal of Clinical Oncology. 38: 10036-10036. DOI: 10.1200/Jco.2020.38.15_Suppl.10036  0.381
2019 Montero J, Gstalder C, Kim DJ, Sadowicz D, Miles W, Manos M, Cidado JR, Paul Secrist J, Tron AE, Flaherty K, Stephen Hodi F, Yoon CH, Letai A, Fisher DE, Haq R. Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies. Nature Communications. 10: 5157. PMID 31727958 DOI: 10.1038/S41467-019-12477-Y  0.383
2019 Buchbinder EI, Weirather JL, Manos MP, Brennick RC, Ott PA, Haq R, Izar B, Hodi FS. Characterization of the genetics of mucosal melanoma in patients treated with immunotherapy. Journal of Clinical Oncology. 37: 9556-9556. DOI: 10.1200/Jco.2019.37.15_Suppl.9556  0.305
2018 Jerby-Arnon L, Shah P, Cuoco MS, Rodman C, Su MJ, Melms JC, Leeson R, Kanodia A, Mei S, Lin JR, Wang S, Rabasha B, Liu D, Zhang G, Margolais C, ... ... Haq R, et al. A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell. 175: 984-997.e24. PMID 30388455 DOI: 10.1016/J.Cell.2018.09.006  0.382
2018 Miao D, Margolis CA, Vokes NI, Liu D, Taylor-Weiner A, Wankowicz SM, Adeegbe D, Keliher D, Schilling B, Tracy A, Manos M, Chau NG, Hanna GJ, Polak P, Rodig SJ, ... ... Haq R, et al. Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors. Nature Genetics. PMID 30150660 DOI: 10.1038/S41588-018-0200-2  0.318
2018 Vokes N, Miao D, Margolis C, Liu D, Wankowicz S, Schilling B, Sholl LM, Getz G, Janne PA, Haddad RI, Choueiri TK, Barbie DA, Haq R, Awad MM, Schadendorf D, et al. Genomic correlates of response to immune checkpoint blockade in microsatellite stable solid tumors. Journal of Clinical Oncology. 36: 3036-3036. DOI: 10.1200/Jco.2018.36.15_Suppl.3036  0.311
2018 Gstalder C, Pancholi P, Sadowicz D, Haq R. Abstract 1698: Loss of MHC-I expression is associated with altered immune microenvironment and decreased response to PD-1 checkpoint inhibition Cancer Research. 78: 1698-1698. DOI: 10.1158/1538-7445.Am2018-1698  0.382
2017 Haq R. Trapping Cancers as They Adapt to Survive. Cancer Discovery. 7: 1216-1217. PMID 29097618 DOI: 10.1158/2159-8290.Cd-17-0976  0.327
2016 Gee MS, Ghazani AA, Haq R, Wargo JA, Sebas M, Sullivan RJ, Lee H, Weissleder R. Point of care assessment of melanoma tumor signaling and metastatic burden from μNMR analysis of tumor fine needle aspirates and peripheral blood. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 27993725 DOI: 10.1016/J.Nano.2016.12.006  0.382
2016 Montero J, Sadowicz DE, Ryan J, Yoon CH, Haq R, Letai A. Abstract 3491: Rational combination of targeted agents and BH3 mimetics to improve cancer treatment Cancer Research. 76: 3491-3491. DOI: 10.1158/1538-7445.Am2016-3491  0.36
2015 Lauss M, Haq R, Cirenajwis H, Phung B, Harbst K, Staaf J, Rosengren F, Holm K, Aine M, Jirström K, Borg Å, Busch C, Geisler J, Lønning PE, Ringnér M, et al. Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation. The Journal of Investigative Dermatology. 135: 1820-8. PMID 25705847 DOI: 10.1038/Jid.2015.61  0.346
2015 Johannessen C, Konieczkowski D, Abudayyeh O, Kim JW, Cooper Z, Piris A, Frederick D, Barzily-Rokni M, Straussman R, Haq R, Fisher D, Mesirov J, Hahn W, Flaherty K, Wargo J, et al. Abstract PR04: A melanoma transcriptional state distinction influences sensitivity to MAPK pathway inhibitors Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Pms14-Pr04  0.418
2015 Montero J, Sadowicz DE, Haq R, Letai A. Abstract C6: Antiapoptotic defense evolution in cancer: novel therapeutic strategies to restore cell death using dynamic BH3 profiling Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C6  0.39
2014 Frederick DT, Salas Fragomeni RA, Schalck A, Ferreiro-Neira I, Hoff T, Cooper ZA, Haq R, Panka DJ, Kwong LN, Davies MA, Cusack JC, Flaherty KT, Fisher DE, Mier JW, Wargo JA, et al. Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics. Plos One. 9: e101286. PMID 24983357 DOI: 10.1371/Journal.Pone.0101286  0.377
2014 Konieczkowski DJ, Johannessen CM, Abudayyeh O, Kim JW, Cooper ZA, Piris A, Frederick DT, Barzily-Rokni M, Straussman R, Haq R, Fisher DE, Mesirov JP, Hahn WC, Flaherty KT, Wargo JA, et al. A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors. Cancer Discovery. 4: 816-27. PMID 24771846 DOI: 10.1158/2159-8290.Cd-13-0424  0.43
2014 Haq R. Metabolic dysregulation in melanoma: cause or consequence? Cancer Discovery. 4: 390-1. PMID 24706656 DOI: 10.1158/2159-8290.Cd-14-0173  0.315
2014 Haq R, Fisher DE, Widlund HR. Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 2257-63. PMID 24610826 DOI: 10.1158/1078-0432.Ccr-13-0898  0.385
2013 Haq R, Fisher DE. Improving apoptotic responses to targeted therapy. Oncotarget. 4: 1331. PMID 23934756 DOI: 10.18632/Oncotarget.1261  0.406
2013 Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe GC, Frederick DT, Hurley AD, Nellore A, Kung AL, Wargo JA, Song JS, Fisher DE, Arany Z, Widlund HR. Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. Cancer Cell. 23: 302-15. PMID 23477830 DOI: 10.1016/J.Ccr.2013.02.003  0.386
2013 Haq R, Yokoyama S, Hawryluk EB, Jönsson GB, Frederick DT, McHenry K, Porter D, Tran TN, Love KT, Langer R, Anderson DG, Garraway LA, Duncan LM, Morton DL, Hoon DS, et al. BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. Proceedings of the National Academy of Sciences of the United States of America. 110: 4321-6. PMID 23447565 DOI: 10.1073/Pnas.1205575110  0.472
2011 Haq R, Fisher DE. Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 3474-82. PMID 21670463 DOI: 10.1200/Jco.2010.32.6223  0.342
2006 McGill GG, Haq R, Nishimura EK, Fisher DE. c-Met expression is regulated by Mitf in the melanocyte lineage. The Journal of Biological Chemistry. 281: 10365-73. PMID 16455654 DOI: 10.1074/Jbc.M513094200  0.334
2002 Haq R, Brenton JD, Takahashi M, Finan D, Finkielsztein A, Damaraju S, Rottapel R, Zanke B. Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Research. 62: 5076-82. PMID 12208764  0.617
2002 Ho JM, Nguyen MH, Dierov JK, Badger KM, Beattie BK, Tartaro P, Haq R, Zanke BW, Carroll MP, Barber DL. TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways. Blood. 100: 1438-48. PMID 12149229 DOI: 10.1182/Blood.V100.4.1438.H81602001438_1438_1448  0.636
2002 Haq R, Halupa A, Beattie BK, Mason JM, Zanke BW, Barber DL. Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases. The Journal of Biological Chemistry. 277: 17359-66. PMID 11875080 DOI: 10.1074/Jbc.M201842200  0.625
2001 Haq R, Randall S, Midmer M, Yee K, Zanke B. NKIATRE is a novel conserved cdc2-related kinase. Genomics. 71: 131-41. PMID 11161806 DOI: 10.1006/Geno.2000.6424  0.637
2000 Jones NL, Islur A, Haq R, Mascarenhas M, Karmali MA, Perdue MH, Zanke BW, Sherman PM. Escherichia coli Shiga toxins induce apoptosis in epithelial cells that is regulated by the Bcl-2 family. American Journal of Physiology. Gastrointestinal and Liver Physiology. 278: G811-9. PMID 10801274 DOI: 10.1152/Ajpgi.2000.278.5.G811  0.598
1999 Midmer M, Haq R, Squire JA, Zanke BW. Identification of NKIAMRE, the human homologue to the mitogen-activated protein kinase-/cyclin-dependent kinase-related protein kinase NKIATRE, and its loss in leukemic blasts with chromosome arm 5q deletion Cancer Research. 59: 4069-4074. PMID 10463609  0.552
1998 Haq R, Zanke B. Inhibition of apoptotic signaling pathways in cancer cells as a mechanism of chemotherapy resistance. Cancer Metastasis Reviews. 17: 233-9. PMID 9770120 DOI: 10.1023/A:1006075007857  0.62
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