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Jonathan A. Ellman - Publications

Affiliations: 
1992-2010 Chemistry University of California, Berkeley, Berkeley, CA 
 1999-2010 Cellular and Molecular Pharmacology University of California, San Francisco, San Francisco, CA 
 2010- Pharmacology Yale University, New Haven, CT 
Area:
chemical synthesis
Website:
http://www.chem.yale.edu/faculty/Ellman.html

311 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Dongbang S, Confair DN, Ellman JA. Rhodium-Catalyzed C-H Alkenylation/Electrocyclization Cascade Provides Dihydropyridines That Serve as Versatile Intermediates to Diverse Nitrogen Heterocycles. Accounts of Chemical Research. PMID 33740369 DOI: 10.1021/acs.accounts.1c00027  0.842
2021 Brandes DS, Sirvent A, Mercado BQ, Ellman JA. Three-Component 1,2-Carboamidation of Bridged Bicyclic Alkenes via Rh-Catalyzed Addition of C-H Bonds and Amidating Reagents. Organic Letters. PMID 33739839 DOI: 10.1021/acs.orglett.1c00851  0.382
2020 Shen Z, Walker MM, Chen S, Parada GA, Chu DM, Dongbang S, Mayer JM, Houk KN, Ellman JA. General Light-Mediated, Highly Diastereoselective Piperidine Epimerization: From Most Accessible to Most Stable Stereoisomer. Journal of the American Chemical Society. PMID 33373212 DOI: 10.1021/jacs.0c11911  0.814
2020 Confair DN, Greenwood NS, Mercado BQ, Ellman JA. Rh(III)-Catalyzed Imidoyl C-H Carbamylation and Cyclization to Bicyclic [1,3,5]Triazinones. Organic Letters. PMID 33172274 DOI: 10.1021/acs.orglett.0c03393  0.361
2020 Dongbang S, Ellman JA. Synthesis of Nitrile Bearing Acyclic Quaternary Centers via Co(III)-Catalyzed Sequential C-H Bond Addition to Dienes and N-Cyanosuccinimide. Angewandte Chemie (International Ed. in English). PMID 33017508 DOI: 10.1002/anie.202010735  0.834
2020 Shen Z, Li C, Mercado BQ, Ellman JA. Cobalt(III)-Catalyzed Diastereoselective Three-Component C-H Bond Addition to Butadiene and Activated Ketones. Synthesis. 52: 1239-1246. PMID 32884161 DOI: 10.1055/S-0039-1690741  0.424
2020 Gannam ZTK, Min K, Shillingford SR, Zhang L, Herrington J, Abriola L, Gareiss PC, Pantouris G, Tzouvelekis A, Kaminski N, Zhang X, Yu J, Jamali H, Ellman JA, Lolis E, et al. An allosteric site on MKP5 reveals a strategy for small-molecule inhibition. Science Signaling. 13. PMID 32843541 DOI: 10.1126/Scisignal.Aba3043  0.775
2020 Walker MM, Koronkiewicz B, Chen S, Houk KN, Mayer JM, Ellman JA. Highly Diastereoselective Functionalization of Piperidines by Photoredox Catalyzed α-Amino C-H Arylation and Epimerization. Journal of the American Chemical Society. PMID 32286827 DOI: 10.1021/Jacs.9B13165  0.825
2020 Streit AD, Zoll AJ, Hoang GL, Ellman JA. Annulation of Hydrazones and Alkynes via Rhodium(III)-Catalyzed Dual C-H Activation: Synthesis of Pyrrolopyridazines and Azolopyridazines. Organic Letters. PMID 31977232 DOI: 10.1021/Acs.Orglett.0C00186  0.83
2019 Maity S, Potter TJ, Ellman JA. α-Branched amines by catalytic 1,1-addition of C-H bonds and aminating agents to terminal alkenes. Nature Catalysis. 2: 756-762. PMID 32879907 DOI: 10.1038/s41929-019-0330-7  0.837
2019 Scamp RJ, deRamon E, Paulson EK, Miller SJ, Ellman JA. Co(III)-Catalyzed C-H Amidation of Dehydroalanine for the Site-Selective Structural Diversification of Thiostrepton. Angewandte Chemie (International Ed. in English). PMID 31742803 DOI: 10.1002/Anie.201911886  0.818
2019 Ellman JA, Ackermann L, Shi BF. The Breadth and Depth of C-H Functionalization. The Journal of Organic Chemistry. 84: 12701-12704. PMID 31623443 DOI: 10.1021/Acs.Joc.9B02663  0.306
2019 Ellman JA, Dongbang S, Chen Z. Synthesis of Homoallylic Alcohols with Acyclic Quaternary Centers via CoIII-Catalyzed Three-Component C-H Bond Addition to Internally Substituted Dienes and Carbonyls. Angewandte Chemie (International Ed. in English). PMID 31310435 DOI: 10.1002/Anie.201906633  0.827
2019 Hoang GL, Zoll AJ, Ellman JA. Three-Component Coupling of Aldehydes, 2-Aminopyridines, and Diazo Esters via Rhodium(III)-Catalyzed Imidoyl C-H Activation: Synthesis of Pyrido[1,2- a]pyrimidin-4-ones. Organic Letters. PMID 30896175 DOI: 10.1021/Acs.Orglett.9B00779  0.841
2019 Dongbang S, Pedersen B, Ellman JA. Asymmetric synthesis of (-)-naltrexone. Chemical Science. 10: 535-541. PMID 30713650 DOI: 10.1039/C8Sc03748E  0.809
2018 Hoang GL, Streit AD, Ellman JA. Three-Component Coupling of Aldehydes, Aminopyrazoles, and Sulfoxonium Ylides via Rhodium(III)-Catalyzed Imidoyl C-H Activation: Synthesis of Pyrazolo[1,5- a]pyrimidines. The Journal of Organic Chemistry. PMID 30525637 DOI: 10.1021/Acs.Joc.8B02606  0.84
2018 Chen S, Chan AY, Walker MM, Ellman JA, Houk KN. π-Facial Selectivities in Hydride Reductions of Hindered Endocyclic Iminium Ions. The Journal of Organic Chemistry. PMID 30516383 DOI: 10.1021/Acs.Joc.8B02603  0.562
2018 Tjin CC, Wissner RF, Jamali H, Schepartz A, Ellman JA. Synthesis and Biological Evaluation of an Indazole-Based Selective Protein Arginine Deiminase 4 (PAD4) Inhibitor. Acs Medicinal Chemistry Letters. 9: 1013-1018. PMID 30344909 DOI: 10.1021/Acsmedchemlett.8B00283  0.795
2018 Boerth JA, Maity S, Williams SK, Mercado BQ, Ellman JA. Selective and synergistic cobalt(III)-catalyzed three-component C-H bond addition to dienes and aldehydes. Nature Catalysis. 1: 673-679. PMID 30221249 DOI: 10.1038/s41929-018-0123-4  0.828
2018 Potter TJ, Li Y, Ward MD, Ellman JA. RhIII-Catalyzed Synthesis of Isoquinolones and 2-Pyridones via Annulation of -Methoxyamides and Nitroalkenes. European Journal of Organic Chemistry. 2018: 4381-4388. PMID 30220876 DOI: 10.1002/Ejoc.201800745  0.82
2018 Hoang GL, Ellman JA. Rhodium(III)-catalyzed C-H functionalization of C-alkenyl azoles with sulfoxonium ylides for the synthesis of bridgehead -fused [5,6]-bicyclic heterocycles. Tetrahedron. 74: 3318-3324. PMID 29988985 DOI: 10.1016/J.Tet.2018.03.062  0.832
2018 Hoang GL, Søholm Halskov K, Ellman JA. Synthesis of Azolo[1,3,5]triazines via Rhodium(III)-Catalyzed Annulation of N-Azolo Imines and Dioxazolones. The Journal of Organic Chemistry. PMID 29947517 DOI: 10.1021/Acs.Joc.8B01249  0.839
2018 Halskov KS, Witten MR, Hoang GL, Mercado BQ, Ellman JA. Rhodium(III)-Catalyzed Imidoyl C-H Activation for Annulations to Azolopyrimidines. Organic Letters. PMID 29582661 DOI: 10.1021/Acs.Orglett.8B00816  0.814
2018 Walker MM, Chen S, Houk K, Ellman JA. Formation of Aminocyclopentadienes from Silyldihydropyridines: Ring Contractions Driven by Anion Stabilization. Angewandte Chemie (International Ed. in English). PMID 29570926 DOI: 10.1002/Anie.201800596  0.615
2017 Hummel JR, Ellman JA. Convergent Synthesis of α-Branched Amines by Transition-Metal-Catalyzed C-H Bond Additions to Imines. Israel Journal of Chemistry. 57: 916-931. PMID 29332949 DOI: 10.1002/Ijch.201700021  0.835
2017 Tjin CC, Otley KD, Baguley TD, Kurup P, Xu J, Nairn AC, Lombroso PJ, Ellman JA. Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases. Acs Central Science. 3: 1322-1328. PMID 29296673 DOI: 10.1021/Acscentsci.7B00486  0.781
2017 Witten MR, Wissler L, Snow M, Geschwindner S, Read JA, Brandon NJ, Nairn AC, Lombroso PJ, Käck H, Ellman JA. X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. Journal of Medicinal Chemistry. PMID 29116812 DOI: 10.1021/Acs.Jmedchem.7B01292  0.791
2017 Tran G, Confair D, Hesp KD, Mascitti V, Ellman JA. C2-Selective Branched Alkylation of Benzimidazoles by Rhodium(I)-Catalyzed C-H Activation. The Journal of Organic Chemistry. PMID 28828857 DOI: 10.1021/Acs.Joc.7B01723  0.826
2017 Ellman JA, Boerth JA. A Convergent Synthesis of Functionalized Alkenyl Halides via Co(III)-Catalyzed Three-Component C-H Bond Addition. Angewandte Chemie (International Ed. in English). PMID 28657674 DOI: 10.1002/Anie.201705817  0.831
2017 Ellman JA, Halksov K, Roth H. Synthesis of [5,6]-Bicyclic Heterocycles with a Ring-Junction Nitrogen via Rh(III)-Catalyzed C-H Functionalization of Alkenyl Azoles. Angewandte Chemie (International Ed. in English). PMID 28586164 DOI: 10.1002/Anie.201703967  0.829
2017 Potter TJ, Ellman JA. Total Synthesis of (+)-Pancratistatin by the Rh(III)-Catalyzed Addition of a Densely Functionalized Benzamide to a Sugar-Derived Nitroalkene. Organic Letters. PMID 28537406 DOI: 10.1021/Acs.Orglett.7B01220  0.831
2017 Potter TJ, Kamber DN, Mercado BQ, Ellman JA. Rh(III)-Catalyzed Aryl and Alkenyl C-H Bond Addition to Diverse Nitroalkenes. Acs Catalysis. 7: 150-153. PMID 28435749 DOI: 10.1021/Acscatal.6B03217  0.822
2017 Tran G, Hesp KD, Mascitti V, Ellman JA. Base-Controlled Completely Selective Linear or Branched Rhodium(I)-Catalyzed C-H ortho-Alkylation of Azines without Preactivation. Angewandte Chemie (International Ed. in English). PMID 28429455 DOI: 10.1002/Anie.201702409  0.818
2016 Hummel JR, Boerth JA, Ellman JA. Transition-Metal-Catalyzed C-H Bond Addition to Carbonyls, Imines, and Related Polarized π Bonds. Chemical Reviews. PMID 27936637 DOI: 10.1021/Acs.Chemrev.6B00661  0.807
2016 Jamali H, Khan HA, Tjin CC, Ellman JA. Cellular Activity of New Small Molecule Protein Arginine Deiminase 3 (PAD3) Inhibitors. Acs Medicinal Chemistry Letters. 7: 847-51. PMID 27660689 DOI: 10.1021/Acsmedchemlett.6B00215  0.781
2016 Chen S, Bacauanu V, Knecht T, Mercado BQ, Bergman RG, Ellman JA. New Regio- and Stereoselective Cascades via Unstabilized Azomethine Ylide Cycloadditions for the Synthesis of Highly Substituted Tropane and Indolizidine Frameworks. Journal of the American Chemical Society. 138: 12664-70. PMID 27642766 DOI: 10.1021/Jacs.6B08355  0.721
2016 Phelan JP, Ellman JA. Conjugate addition-enantioselective protonation reactions. Beilstein Journal of Organic Chemistry. 12: 1203-28. PMID 27559372 DOI: 10.3762/Bjoc.12.116  0.66
2016 Potter TJ, Ellman JA. Rh(III)-Catalyzed C-H Bond Addition/Amine-Mediated Cyclization of Bis-Michael Acceptors. Organic Letters. PMID 27437933 DOI: 10.1021/Acs.Orglett.6B01846  0.829
2016 Weinstein AB, Ellman JA. Convergent Synthesis of Diverse Nitrogen Heterocycles via Rh(III)-Catalyzed C-H Conjugate Addition/Cyclization Reactions. Organic Letters. PMID 27337641 DOI: 10.1021/Acs.Orglett.6B01611  0.79
2016 Boerth JA, Hummel JR, Ellman JA. Highly Stereoselective Cobalt(III)-Catalyzed Three-Component C-H Bond Addition Cascade. Angewandte Chemie (International Ed. in English). PMID 27305062 DOI: 10.1002/Anie.201603831  0.832
2016 Boerth JA, Ellman JA. Rh(III)-Catalyzed Diastereoselective C-H Bond Addition/Cyclization Cascade of Enone Tethered Aldehydes. Chemical Science (Royal Society of Chemistry : 2010). 7: 1474-1479. PMID 26918112 DOI: 10.1039/C5Sc04138D  0.831
2016 Wangweerawong A, Hummel JR, Bergman RG, Ellman JA. Preparation of Enantiomerically Pure Perfluorobutanesulfinamide and Its Application to the Asymmetric Synthesis of α-Amino Acids. The Journal of Organic Chemistry. PMID 26844947 DOI: 10.1021/Acs.Joc.5B02700  0.841
2016 Phelan JP, Ellman JA. Catalytic Enantioselective Addition of Pyrazol-5-ones to Trisubstituted Nitroalkenes with an N-Sulfinylurea Organocatalyst Advanced Synthesis and Catalysis. 358: 1713-1718. DOI: 10.1002/Adsc.201600110  0.68
2016 Wangweerawong A, Kolmar S, Ellman JA. Preparation of (S)‐Nonafluorobutanesulfinamide Organic Syntheses. 93: 319-330. DOI: 10.1002/0471264229.Os093.23  0.77
2015 Matsushima Y, Phillips EM, Bergman RG, Ellman JA. Rh(I)-Catalyzed Cycloisomerization of 1,6-Enynes. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 26: 1533-1536. PMID 26609195 DOI: 10.1055/S-0034-1380359  0.675
2015 Xu J, Kurup P, Baguley TD, Foscue E, Ellman JA, Nairn AC, Lombroso PJ. Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice. Cellular and Molecular Life Sciences : Cmls. PMID 26450419 DOI: 10.1007/S00018-015-2057-1  0.771
2015 Phillips EM, Mesganaw T, Patel A, Duttwyler S, Mercado BQ, Houk KN, Ellman JA. Synthesis of ent-ketorfanol via a C-H alkenylation/torquoselective 6π electrocyclization cascade. Angewandte Chemie (International Ed. in English). 54: 12044-8. PMID 26385263 DOI: 10.1002/Anie.201505604  0.835
2015 Xu J, Kurup P, Azkona G, Baguley TD, Saavedra A, Nairn AC, Ellman JA, Pérez-Navarro E, Lombroso PJ. Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels. Journal of Neurochemistry. PMID 26316048 DOI: 10.1111/Jnc.13295  0.775
2015 Azkona G, Saavedra A, Aira Z, Aluja D, Xifró X, Baguley T, Alberch J, Ellman JA, Lombroso PJ, Azkue JJ, Pérez-Navarro E. STEP modulates nociception: evidences from genetic deletion and pharmacological inhibition. Pain. PMID 26270590 DOI: 10.1097/J.Pain.0000000000000329  0.768
2015 Neitz RJ, Bryant C, Chen S, Gut J, Hugo Caselli E, Ponce S, Chowdhury S, Xu H, Arkin MR, Ellman JA, Renslo AR. Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease. Bioorganic & Medicinal Chemistry Letters. 25: 4834-7. PMID 26144347 DOI: 10.1016/J.Bmcl.2015.06.066  0.786
2015 Chen S, Mercado BQ, Bergman RG, Ellman JA. Regio- and Diastereoselective Synthesis of Highly Substituted, Oxygenated Piperidines from Tetrahydropyridines. The Journal of Organic Chemistry. 80: 6660-8. PMID 26098485 DOI: 10.1021/Acs.Joc.5B00816  0.714
2015 Chen S, Bergman RG, Ellman JA. Facile Rh(III)-Catalyzed Synthesis of Fluorinated Pyridines. Organic Letters. 17: 2567-9. PMID 25992591 DOI: 10.1021/Acs.Orglett.5B00979  0.696
2015 Hummel JR, Ellman JA. Cobalt(III)-Catalyzed C-H Bond Amidation with Isocyanates. Organic Letters. 17: 2400-3. PMID 25945401 DOI: 10.1021/Acs.Orglett.5B00910  0.823
2015 Oresic Bender K, Ofori L, van der Linden WA, Mock ED, Datta GK, Chowdhury S, Li H, Segal E, Sanchez Lopez M, Ellman JA, Figdor CG, Bogyo M, Verdoes M. Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization. Journal of the American Chemical Society. 137: 4771-7. PMID 25785540 DOI: 10.1021/Jacs.5B00315  0.792
2015 Jamali H, Khan HA, Stringer JR, Chowdhury S, Ellman JA. Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method. Journal of the American Chemical Society. 137: 3616-21. PMID 25742366 DOI: 10.1021/Jacs.5B00095  0.785
2015 Otley KD, Ellman JA. An efficient method for the preparation of styrene derivatives via Rh(III)-catalyzed direct C-H vinylation. Organic Letters. 17: 1332-5. PMID 25715077 DOI: 10.1021/Acs.Orglett.5B00340  0.827
2015 Baguley TD, Nairn AC, Lombroso PJ, Ellman JA. Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP. Bioorganic & Medicinal Chemistry Letters. 25: 1044-6. PMID 25666825 DOI: 10.1016/J.Bmcl.2015.01.020  0.812
2015 Hummel JR, Ellman JA. Cobalt(III)-catalyzed synthesis of indazoles and furans by C-H bond functionalization/addition/cyclization cascades. Journal of the American Chemical Society. 137: 490-8. PMID 25494296 DOI: 10.1021/Ja5116452  0.817
2015 Matsushima Y, Phillips EM, Bergman RG, Ellman JA. Rhodium(I)-Catalyzed Cycloisomerization of 1,6-Enynes Synlett. 26: 1533-1536. DOI: 10.1055/s-0034-1380359  0.67
2015 Phillips EM, Mesganaw T, Patel A, Duttwyler S, Mercado BQ, Houk KN, Ellman JA. Synthesis of ent-Ketorfanol via a C-H Alkenylation/Torquoselective 6π Electrocyclization Cascade Angewandte Chemie - International Edition. 54: 12044-12048. DOI: 10.1002/anie.201505604  0.811
2014 Mesganaw T, Ellman JA. Preparative Synthesis of Highly Substituted Tetrahydropyridines via a Rh(I)-Catalyzed C-H Functionalization Sequence. Organic Process Research & Development. 18: 1105-1109. PMID 25288872 DOI: 10.1021/Op500225C  0.832
2014 Mesganaw T, Ellman JA. Convergent Synthesis of Diverse Tetrahydropyridines via Rh(I)-Catalyzed C-H Functionalization Sequences. Organic Process Research & Development. 18: 1097-1104. PMID 25288871 DOI: 10.1021/Op500224X  0.837
2014 Phelan JP, Patel EJ, Ellman JA. Catalytic enantioselective addition of thioacids to trisubstituted nitroalkenes. Angewandte Chemie (International Ed. in English). 53: 11329-32. PMID 25196997 DOI: 10.1002/Anie.201406971  0.683
2014 Otley KD, Ellman JA. A Lewis Acid Catalyzed annulation to 2,1-benzisoxazoles. The Journal of Organic Chemistry. 79: 8296-303. PMID 25157596 DOI: 10.1021/Jo5015432  0.823
2014 Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, ... ... Ellman JA, et al. Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease. Plos Biology. 12: e1001923. PMID 25093460 DOI: 10.1371/Journal.Pbio.1001923  0.792
2014 Wangweerawong A, Bergman RG, Ellman JA. Asymmetric synthesis of α-branched amines via Rh(III)-catalyzed C-H bond functionalization. Journal of the American Chemical Society. 136: 8520-3. PMID 24901217 DOI: 10.1021/Ja5033452  0.835
2014 Buesking AW, Bacauanu V, Cai I, Ellman JA. Asymmetric synthesis of protected α-amino boronic acid derivatives with an air- and moisture-stable Cu(II) catalyst. The Journal of Organic Chemistry. 79: 3671-7. PMID 24684495 DOI: 10.1021/Jo500300T  0.815
2014 Duttwyler S, Chen S, Lu C, Mercado BQ, Bergman RG, Ellman JA. Regio- and stereoselective 1,2-dihydropyridine alkylation/addition sequence for the synthesis of piperidines with quaternary centers. Angewandte Chemie (International Ed. in English). 53: 3877-80. PMID 24604837 DOI: 10.1002/Anie.201310517  0.799
2014 Lautens M, Sickert M, Buesking AW, Bacauanu V, Cai I, Ellman JA. Borylation of Chiral Imines Catalyzed by Copper(II) Synfacts. 10: 711-711. DOI: 10.1055/S-0034-1378283  0.421
2014 Buesking AW, Ellman JA. Convergent, asymmetric synthesis of vicinal amino alcohols via Rh-catalyzed addition of α-amido trifluoroborates to carbonyls Chemical Science. 5: 1983-1987. DOI: 10.1039/C4Sc00084F  0.823
2014 Duttwyler S, Lu C, Rheingold AL, Bergman RG, Ellman JA. Correction to “Highly Diastereoselective Synthesis of Tetrahydropyridines by a C–H Activation–Cyclization–Reduction Cascade” Journal of the American Chemical Society. 136: 11849-11849. DOI: 10.1021/Ja507742P  0.812
2013 Xu HC, Chowdhury S, Ellman JA. Asymmetric synthesis of amines using tert-butanesulfinamide. Nature Protocols. 8: 2271-80. PMID 24157547 DOI: 10.1038/Nprot.2013.134  0.807
2013 Baguley TD, Xu HC, Chatterjee M, Nairn AC, Lombroso PJ, Ellman JA. Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase. Journal of Medicinal Chemistry. 56: 7636-50. PMID 24083656 DOI: 10.1021/Jm401037H  0.79
2013 Lian Y, Hummel JR, Bergman RG, Ellman JA. Facile synthesis of unsymmetrical acridines and phenazines by a Rh(III)-catalyzed amination/cyclization/aromatization cascade. Journal of the American Chemical Society. 135: 12548-51. PMID 23957711 DOI: 10.1021/Ja406131A  0.833
2013 Lian Y, Bergman RG, Lavis LD, Ellman JA. Rhodium(III)-catalyzed indazole synthesis by C-H bond functionalization and cyclative capture. Journal of the American Chemical Society. 135: 7122-5. PMID 23642256 DOI: 10.1021/Ja402761P  0.736
2013 Brasse M, Cámpora J, Ellman JA, Bergman RG. Mechanistic study of the oxidative coupling of styrene with 2-phenylpyridine derivatives catalyzed by cationic rhodium(III) via C-H activation. Journal of the American Chemical Society. 135: 6427-30. PMID 23590843 DOI: 10.1021/Ja401561Q  0.826
2013 Ischay MA, Takase MK, Bergman RG, Ellman JA. Unstabilized azomethine ylides for the stereoselective synthesis of substituted piperidines, tropanes, and azabicyclo[3.1.0] systems. Journal of the American Chemical Society. 135: 2478-81. PMID 23398467 DOI: 10.1021/Ja312311K  0.808
2013 Duttwyler S, Chen S, Takase MK, Wiberg KB, Bergman RG, Ellman JA. Proton donor acidity controls selectivity in nonaromatic nitrogen heterocycle synthesis. Science (New York, N.Y.). 339: 678-82. PMID 23393259 DOI: 10.1126/Science.1230704  0.823
2013 Martin RM, Bergman RG, Ellman JA. Synthesis of isoquinuclidines from highly substituted dihydropyridines via the Diels-Alder reaction. Organic Letters. 15: 444-7. PMID 23320852 DOI: 10.1021/Ol303040R  0.558
2013 Lian Y, Huber T, Hesp KD, Bergman RG, Ellman JA. Rhodium(III)-catalyzed alkenyl C-H bond functionalization: convergent synthesis of furans and pyrroles. Angewandte Chemie (International Ed. in English). 52: 629-33. PMID 23172703 DOI: 10.1002/Anie.201207995  0.739
2013 Khan HA, Ellman JA. Asymmetric synthesis of α-aminophosphonate esters by the addition of dialkyl phosphites to tert-butanesulfinyl imines Synthesis (Germany). 45: 3147-3150. DOI: 10.1055/S-0033-1339712  0.618
2013 Duttwyler S, Chen S, Takase MK, Wiberg KB, Bergman RG, Ellman JA. Nitrogen-Containing Heterocycle Synthesis Initiated by Rh(III)-Catalyzed C−H Activation Synfacts. 9: 521-521. DOI: 10.1055/S-0033-1338387  0.551
2012 Jung HH, Buesking AW, Ellman JA. Rh-catalyzed addition of arylboroxines to cyclic N-(isopropanesulfinyl)ketimines. The Journal of Organic Chemistry. 77: 9593-600. PMID 23094717 DOI: 10.1021/Jo301634Y  0.817
2012 Lian Y, Bergman RG, Ellman JA. Rhodium(iii)-catalyzed synthesis of phthalides by cascade addition and cyclization of benzimidates with aldehydes. Chemical Science (Royal Society of Chemistry : 2010). 3: 3088-3092. PMID 23050074 DOI: 10.1039/C2Sc20835K  0.731
2012 Kimmel KL, Weaver JD, Lee M, Ellman JA. Catalytic enantioselective protonation of nitronates utilizing an organocatalyst chiral only at sulfur. Journal of the American Chemical Society. 134: 9058-61. PMID 22621169 DOI: 10.1021/Ja3026196  0.827
2012 Xue Y, Chowdhury S, Liu X, Akiyama Y, Ellman J, Ha Y. Conformational change in rhomboid protease GlpG induced by inhibitor binding to its S' subsites. Biochemistry. 51: 3723-31. PMID 22515733 DOI: 10.1021/Bi300368B  0.707
2012 Hesp KD, Bergman RG, Ellman JA. Rhodium-catalyzed synthesis of branched amines by direct addition of benzamides to imines. Organic Letters. 14: 2304-7. PMID 22500854 DOI: 10.1021/Ol300723X  0.611
2012 Duttwyler S, Lu C, Rheingold AL, Bergman RG, Ellman JA. Highly diastereoselective synthesis of tetrahydropyridines by a C-H activation-cyclization-reduction cascade. Journal of the American Chemical Society. 134: 4064-7. PMID 22356093 DOI: 10.1021/Ja2119833  0.84
2012 Martin RM, Bergman RG, Ellman JA. Synthesis of pyridines from ketoximes and terminal alkynes via C-H bond functionalization. The Journal of Organic Chemistry. 77: 2501-7. PMID 22332639 DOI: 10.1021/Jo202280E  0.568
2012 Tauchert ME, Incarvito CD, Rheingold AL, Bergman RG, Ellman JA. Mechanism of the rhodium(III)-catalyzed arylation of imines via C-H bond functionalization: inhibition by substrate. Journal of the American Chemical Society. 134: 1482-5. PMID 22257031 DOI: 10.1021/Ja211110H  0.83
2012 Colby DA, Tsai AS, Bergman RG, Ellman JA. Rhodium catalyzed chelation-assisted C-H bond functionalization reactions. Accounts of Chemical Research. 45: 814-25. PMID 22148885 DOI: 10.1021/Ar200190G  0.784
2012 Snieckus V, Rantanen T, Martin RM, Bergman RG, Ellman JA. Rh-Catalyzed De Novo Synthesis of Pyridines from Terminal Alkynes and Ketoximes Synfacts. 8: 607-607. DOI: 10.1055/S-0031-1291070  0.573
2012 Kimmel KL, Weaver JD, Ellman JA. Enantio- and diastereoselective addition of cyclohexyl Meldrum's acid to β- And α,β-disubstituted nitroalkenes via N-sulfinyl urea catalysis Chemical Science. 3: 121-125. DOI: 10.1039/C1Sc00441G  0.807
2012 Kimmel KL, Weaver JD, Lee M, Ellman JA. Correction to Catalytic Enantioselective Protonation of Nitronates Utilizing an Organocatalyst Chiral Only at Sulfur Journal of the American Chemical Society. 134: 11828-11828. DOI: 10.1021/Ja306016B  0.799
2012 Kimmel KL, Robak MT, Thomas S, Lee M, Ellman JA. Enantio- and diastereoselective addition of thioacetic acid to nitroalkenes via N-sulfinyl urea catalysis Tetrahedron. 68: 2704-2712. DOI: 10.1016/J.Tet.2012.01.048  0.815
2011 Jung HH, Buesking AW, Ellman JA. Highly functional group compatible Rh-catalyzed addition of arylboroxines to activated N-tert-butanesulfinyl ketimines. Organic Letters. 13: 3912-5. PMID 21732591 DOI: 10.1021/Ol201438K  0.811
2011 Hesp KD, Bergman RG, Ellman JA. Expedient synthesis of N-acyl anthranilamides and β-enamine amides by the Rh(III)-catalyzed amidation of aryl and vinyl C-H bonds with isocyanates. Journal of the American Chemical Society. 133: 11430-3. PMID 21714533 DOI: 10.1021/Ja203495C  0.577
2011 Brasse M, Ellman JA, Bergman RG. A facile, metal- and solvent-free, autoxidative coupling of quinolines with indoles and pyrroles. Chemical Communications (Cambridge, England). 47: 5019-21. PMID 21445416 DOI: 10.1039/C1Cc10507H  0.802
2011 Buesking AW, Baguley TD, Ellman JA. Asymmetric synthesis of amines by the Knochel-type MgCl2-enhanced addition of benzyl zinc reagents to N-tert-butanesulfinyl aldimines. Organic Letters. 13: 964-7. PMID 21306151 DOI: 10.1021/Ol103002T  0.822
2011 Tsai AS, Tauchert ME, Bergman RG, Ellman JA. Rhodium(III)-catalyzed arylation of Boc-imines via C-H bond functionalization. Journal of the American Chemical Society. 133: 1248-50. PMID 21204527 DOI: 10.1021/Ja109562X  0.829
2011 Tsai AS, Brasse M, Bergman RG, Ellman JA. Rh(III)-catalyzed oxidative coupling of unactivated alkenes via C-H activation. Organic Letters. 13: 540-2. PMID 21175143 DOI: 10.1021/Ol102890K  0.805
2011 Crimmin MR, Colby DA, Ellman JA, Bergman RG. Synthesis and coordination chemistry of tri-substituted benzamidrazones. Dalton Transactions (Cambridge, England : 2003). 40: 514-22. PMID 21109860 DOI: 10.1039/C0Dt01267J  0.745
2011 Floyd WC, Datta GK, Imamura S, Kieler-Ferguson HM, Jerger K, Patterson AW, Fox ME, Szoka FC, Fréchet JM, Ellman JA. Chemotherapeutic evaluation of a synthetic tubulysin analogue-dendrimer conjugate in c26 tumor bearing mice. Chemmedchem. 6: 49-53. PMID 20973119 DOI: 10.1002/Cmdc.201000377  0.807
2011 Coppe J, Prathapam T, Chen Z, Mukherjee B, Xu Z, Chen Y, Rosa-Bauza Y, Park N, Ellman J, Martin S, Gray J, Chen F, Veer Lv, Liu L. Abstract C89: Functional kinomic-screening platform to explore oncogenic kinase networks. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C89  0.777
2011 Tsai AS, Brasse M, Bergman RG, Ellman JA. Rh(III)-Catalyzed C-H Activation and Oxidative Couplingwith Alkenes Synfacts. 2011: 423-423. DOI: 10.1055/S-0030-1259604  0.486
2011 Robak MT, Herbage MA, Ellman JA. Development of an N-sulfinyl prolinamide for the asymmetric aldol reaction Tetrahedron. 67: 4412-4416. DOI: 10.1016/J.Tet.2011.03.030  0.824
2010 Berman AM, Bergman RG, Ellman JA. Rh(I)-catalyzed direct arylation of azines. The Journal of Organic Chemistry. 75: 7863-8. PMID 21033740 DOI: 10.1021/Jo101793R  0.71
2010 Datta GK, Ellman JA. Racemization free protocol for the synthesis of N-tert-butanesulfinyl ketimines. The Journal of Organic Chemistry. 75: 6283-5. PMID 20735147 DOI: 10.1021/Jo1011625  0.815
2010 Nichols JM, Bishop LM, Bergman RG, Ellman JA. Catalytic C-O bond cleavage of 2-aryloxy-1-arylethanols and its application to the depolymerization of lignin-related polymers. Journal of the American Chemical Society. 132: 12554-5. PMID 20731348 DOI: 10.1021/Ja106101F  0.671
2010 Arceo E, Ellman JA, Bergman RG. Rhenium-catalyzed didehydroxylation of vicinal diols to alkenes using a simple alcohol as a reducing agent. Journal of the American Chemical Society. 132: 11408-9. PMID 20669903 DOI: 10.1021/Ja103436V  0.813
2010 Rawls KA, Grundner C, Ellman JA. Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB. Organic & Biomolecular Chemistry. 8: 4066-70. PMID 20644889 DOI: 10.1039/C0Ob00182A  0.804
2010 Yotphan S, Bergman RG, Ellman JA. Synthesis of multicyclic pyridine and quinoline derivatives via intramolecular C-H bond functionalization. Organic Letters. 12: 2978-81. PMID 20518526 DOI: 10.1021/Ol101002B  0.58
2010 Arceo E, Ellman JA, Bergman RG. A direct, biomass-based synthesis of benzoic acid: formic acid-mediated deoxygenation of the glucose-derived materials quinic acid and shikimic acid. Chemsuschem. 3: 811-3. PMID 20512802 DOI: 10.1002/Cssc.201000111  0.791
2010 Robak MT, Herbage MA, Ellman JA. Synthesis and applications of tert-butanesulfinamide. Chemical Reviews. 110: 3600-740. PMID 20420386 DOI: 10.1021/Cr900382T  0.801
2010 Brak K, Ellman JA. Asymmetric Rh(I)-catalyzed addition of MIDA boronates to N-tert-butanesulfinyl aldimines: development and comparison to trifluoroborates. The Journal of Organic Chemistry. 75: 3147-50. PMID 20387846 DOI: 10.1021/Jo100318S  0.833
2010 Brak K, Ellman JA. Total synthesis of (-)-aurantioclavine. Organic Letters. 12: 2004-7. PMID 20356065 DOI: 10.1021/Ol100470G  0.833
2010 Sun C, Su KH, Valentine J, Rosa-Bauza YT, Ellman JA, Elboudwarej O, Mukherjee B, Craik CS, Shuman MA, Chen FF, Zhang X. Time-resolved single-step protease activity quantification using nanoplasmonic resonator sensors. Acs Nano. 4: 978-84. PMID 20121209 DOI: 10.1021/nn900757p  0.772
2010 Brak K, Kerr ID, Barrett KT, Fuchi N, Debnath M, Ang K, Engel JC, McKerrow JH, Doyle PS, Brinen LS, Ellman JA. Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. Journal of Medicinal Chemistry. 53: 1763-73. PMID 20088534 DOI: 10.1021/Jm901633V  0.788
2010 Drag M, Bogyo M, Ellman JA, Salvesen GS. Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors. The Journal of Biological Chemistry. 285: 3310-8. PMID 19948737 DOI: 10.1074/Jbc.M109.060418  0.361
2010 Colby DA, Bergman RG, Ellman JA. Rhodium-catalyzed C-C bond formation via heteroatom-directed C-H bond activation. Chemical Reviews. 110: 624-55. PMID 19438203 DOI: 10.1021/Cr900005N  0.772
2010 Ellman J, Brak K. Synthesis of (-)-Aurantioclavine Synfacts. 2010: 0978-0978. DOI: 10.1055/S-0030-1257932  0.814
2010 Kitazawa K, Kochi T, Kakiuchi F, Chowdhury S, Ellman JA. Ruthenium-catalyzed arylation of ortho C-H bond in an aromatic with an arylboronate: 8-phenyl-1-tetralone Organic Syntheses. 87: 209-217. DOI: 10.1002/0471264229.Os087.23  0.6
2010 Alvarado J, Do HQ, Daugulis O, Marsden PC, Ellman JA. A general method for copper-catalyzed arylation of acidic arene C-H bonds. Preparation of 2-chloro-5-(3-methylphenyl)-thiophene Organic Syntheses. 87: 184-191.  0.303
2010 DeBerardinis AM, Turlington M, Pu L, Kimmel KL, Ellman JA. Catalytic asymmetric addition of an in-situ prepared arylzinc to cyclohexanecarboxaldehyde: (R)-(+)-α-cyclohexyl-3-methoxy-benzenemethanol Organic Syntheses. 87: 68-76.  0.786
2010 Turlington M, Pu L, Kimmel KL, Ellman JA. Preparation of (S')-3,3,-bis-morpholinomethyl- 5,5',6,6',7,7',8,8'- octahydro-1,1,-BI-2-naphthol Organic Syntheses. 87: 59-67.  0.784
2009 Rawls KA, Lang PT, Takeuchi J, Imamura S, Baguley TD, Grundner C, Alber T, Ellman JA. Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Bioorganic & Medicinal Chemistry Letters. 19: 6851-4. PMID 19889539 DOI: 10.1016/J.Bmcl.2009.10.090  0.782
2009 Tsai AS, Wilson RM, Harada H, Bergman RG, Ellman JA. Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C-H bond activation. Chemical Communications (Cambridge, England). 3910-2. PMID 19662249 DOI: 10.1039/B902878A  0.541
2009 Arceo E, Marsden P, Bergman RG, Ellman JA. An efficient didehydroxylation method for the biomass-derived polyols glycerol and erythritol. Mechanistic studies of a formic acid-mediated deoxygenation. Chemical Communications (Cambridge, England). 3357-9. PMID 19503869 DOI: 10.1039/B907746D  0.796
2009 Kimmel KL, Robak MT, Ellman JA. Enantioselective addition of thioacetic acid to nitroalkenes via N-sulfinyl urea organocatalysis. Journal of the American Chemical Society. 131: 8754-5. PMID 19496569 DOI: 10.1021/Ja903351A  0.823
2009 Brak K, Barrett KT, Ellman JA. General one-pot method for the preparation of N-tert-butanesulfinylamine diastereomer mixtures as standards for stereoselectivity determinations. The Journal of Organic Chemistry. 74: 3606-8. PMID 19351149 DOI: 10.1021/Jo900353P  0.797
2009 Wakayama M, Ellman JA. Recycling the tert-butanesulfinyl group in the synthesis of amines using tert-butanesulfinamide. The Journal of Organic Chemistry. 74: 2646-50. PMID 19323570 DOI: 10.1021/Jo9001883  0.387
2009 Yotphan S, Bergman RG, Ellman JA. Application of Daugulis copper-catalyzed direct arylation to the synthesis of 5-aryl benzotriazepines. Organic Letters. 11: 1511-4. PMID 19260648 DOI: 10.1021/Ol900103A  0.537
2009 Brak K, Ellman JA. Asymmetric synthesis of alpha-branched allylic amines by the Rh(I)-catalyzed addition of alkenyltrifluoroborates to N-tert-butanesulfinyl aldimines. Journal of the American Chemical Society. 131: 3850-1. PMID 19256498 DOI: 10.1021/Ja9002603  0.829
2009 Berman AM, Lewis JC, Bergman RG, Ellman JA. Direct Arylation of α-Substituted Pyridines andQuinolines Synfacts. 2009: 195-195. DOI: 10.1055/S-0028-1087659  0.476
2009 Greszler S, Stevens KL, Nakagawa H, Ellman JA. Synthesis of pyrazolo[1,5-a]pyridines via azirines: Preparation of 2-(3-bromophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine Organic Syntheses. 86: 18-27.  0.315
2009 Glasnov TN, Oliver Kappe C, Robak MT, Ellman JA. One-pot multicomponent preparation of tetrahydropyrazoloquinolinones and tetrahydropyrazoloquinazolinones Organic Syntheses. 86: 252-261.  0.798
2009 Storgaard M, Ellman JA, Bexrud JA, Lautens M. Rhodium-catalyzed enantioselective addition of arylboronic acids to in situ generated n-boc arylimines. preparation of (s)-tert-butyl (4chlorophenyl) (thiophen-2-yl)methylcarbamate Organic Syntheses. 86: 360-373.  0.424
2008 Gribble MW, Ellman JA, Bergman RG. Synthesis of a Benzodiazepine-derived Rhodium NHC Complex by C-H Bond Activation. Organometallics. 27: 2152-2155. PMID 21191469 DOI: 10.1021/Om8000839  0.545
2008 Berman AM, Lewis JC, Bergman RG, Ellman JA. Rh(I)-catalyzed direct arylation of pyridines and quinolines. Journal of the American Chemical Society. 130: 14926-7. PMID 18855360 DOI: 10.1021/Ja8059396  0.781
2008 Harada H, Thalji RK, Bergman RG, Ellman JA. Enantioselective intramolecular hydroarylation of alkenes via directed C-H bond activation. The Journal of Organic Chemistry. 73: 6772-9. PMID 18681407 DOI: 10.1021/Jo801098Z  0.821
2008 Lewis JC, Bergman RG, Ellman JA. Direct functionalization of nitrogen heterocycles via Rh-catalyzed C-H bond activation. Accounts of Chemical Research. 41: 1013-25. PMID 18616300 DOI: 10.1021/Ar800042P  0.73
2008 Trincado M, Ellman JA. Enantioselective synthesis of alpha-aryl alkylamines by Rh-catalyzed addition reactions of arylboronic acids to aliphatic imines. Angewandte Chemie (International Ed. in English). 47: 5623-6. PMID 18574834 DOI: 10.1002/Anie.200801137  0.759
2008 Patterson AW, Peltier HM, Ellman JA. Expedient synthesis of N-methyl tubulysin analogues with high cytotoxicity. The Journal of Organic Chemistry. 73: 4362-9. PMID 18479168 DOI: 10.1021/Jo800384X  0.817
2008 Beenen MA, An C, Ellman JA. Asymmetric copper-catalyzed synthesis of alpha-amino boronate esters from N-tert-butanesulfinyl aldimines. Journal of the American Chemical Society. 130: 6910-1. PMID 18461938 DOI: 10.1021/Ja800829Y  0.421
2008 Tsai AS, Bergman RG, Ellman JA. Asymmetric synthesis of (-)-incarvillateine employing an intramolecular alkylation via Rh-catalyzed olefinic C-H bond activation. Journal of the American Chemical Society. 130: 6316-7. PMID 18444613 DOI: 10.1021/Ja8012159  0.599
2008 Brak K, Doyle PS, McKerrow JH, Ellman JA. Identification of a new class of nonpeptidic inhibitors of cruzain. Journal of the American Chemical Society. 130: 6404-10. PMID 18435536 DOI: 10.1021/Ja710254M  0.801
2008 Colby DA, Bergman RG, Ellman JA. Synthesis of dihydropyridines and pyridines from imines and alkynes via C-H activation. Journal of the American Chemical Society. 130: 3645-51. PMID 18302381 DOI: 10.1021/Ja7104784  0.77
2008 Lewis JC, Berman AM, Bergman RG, Ellman JA. Rh(I)-catalyzed arylation of heterocycles via C-H bond activation: expanded scope through mechanistic insight. Journal of the American Chemical Society. 130: 2493-500. PMID 18251465 DOI: 10.1021/Ja0748985  0.786
2008 Yotphan S, Bergman RG, Ellman JA. The stereoselective formation of bicyclic enamines with bridgehead unsaturation via tandem C-H bond activation/alkenylation/electrocyclization. Journal of the American Chemical Society. 130: 2452-3. PMID 18247623 DOI: 10.1021/Ja710981B  0.533
2008 Tsai AS, Bergman RG, Ellman JA. Synthesis of (-)-Incarvillateine Synfacts. 2008: 1254-1254. DOI: 10.1055/S-0028-1087287  0.525
2008 Harada H, Thalji RK, Bergman RG, Ellman JA. Enantioselective Hydroarylation of Alkenes via C-HActivation Synfacts. 2008: 1295-1295. DOI: 10.1055/S-0028-1083619  0.481
2008 Rostovtsev VV, Snieckus V, Macklin T, Grushin VV, Ishiyama T, Miyaura N, Kakiuchi F, Dyker G, Kobayashi S, Bandini M, Melloni A, Piccinelli F, Reetz MT, Sommer K, Murai S, ... ... Ellman JA, et al. C-H Transformation at Arenes Handbook of C-H Transformations: Applications in Organic Synthesis. 1: 99-276. DOI: 10.1002/9783527619450.ch5  0.375
2007 Robak MT, Trincado M, Ellman JA. Enantioselective aza-Henry reaction with an N-sulfinyl urea organocatalyst. Journal of the American Chemical Society. 129: 15110-1. PMID 18004853 DOI: 10.1021/Ja075653V  0.828
2007 Nakagawa H, Rech JC, Sindelar RW, Ellman JA. Catalytic enantioselective addition of arylboronic acids to N-boc imines generated in situ. Organic Letters. 9: 5155-7. PMID 17988138 DOI: 10.1021/Ol702045W  0.763
2007 Patterson AW, Peltier HM, Sasse F, Ellman JA. Design, synthesis, and biological properties of highly potent tubulysin D analogues. Chemistry (Weinheim An Der Bergstrasse, Germany). 13: 9534-41. PMID 17828721 DOI: 10.1002/Chem.200701057  0.799
2007 Liu GL, Rosa-Bauza YT, Salisbury CM, Craik C, Ellman JA, Chen FF, Lee LP. Peptide-nanoparticle hybrid SERS probes for optical detection of protease activity. Journal of Nanoscience and Nanotechnology. 7: 2323-30. PMID 17663247 DOI: 10.1166/Jnn.2007.444  0.767
2007 Soellner MB, Rawls KA, Grundner C, Alber T, Ellman JA. Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB. Journal of the American Chemical Society. 129: 9613-5. PMID 17636914 DOI: 10.1021/Ja0727520  0.783
2007 Rosa-Bauzá YT, Berst F, Ellman JA. Straightforward preparation and assay of aspartyl protease substrates with an internal thioester linkage. Chembiochem : a European Journal of Chemical Biology. 8: 981-4. PMID 17492698 DOI: 10.1002/Cbic.200700008  0.785
2007 Inagaki H, Tsuruoka H, Hornsby M, Lesley SA, Spraggon G, Ellman JA. Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode. Journal of Medicinal Chemistry. 50: 2693-9. PMID 17469812 DOI: 10.1021/Jm070111+  0.572
2007 Lewis JC, Bergman RG, Ellman JA. Rh(I)-catalyzed alkylation of quinolines and pyridines via C-H bond activation. Journal of the American Chemical Society. 129: 5332-3. PMID 17411050 DOI: 10.1021/Ja070388Z  0.704
2007 Patterson AW, Wood WJ, Ellman JA. Substrate activity screening (SAS): a general procedure for the preparation and screening of a fragment-based non-peptidic protease substrate library for inhibitor discovery. Nature Protocols. 2: 424-33. PMID 17406604 DOI: 10.1038/Nprot.2007.28  0.786
2007 Rech JC, Yato M, Duckett D, Ember B, LoGrasso PV, Bergman RG, Ellman JA. Synthesis of potent bicyclic bisarylimidazole c-Jun N-terminal kinase inhibitors by catalytic C-H bond activation. Journal of the American Chemical Society. 129: 490-1. PMID 17227002 DOI: 10.1021/Ja0676004  0.8
2007 Tanuwidjaja J, Peltier HM, Ellman JA. One-pot asymmetric synthesis of either diastereomer of tert-butanesulfinyl-protected amines from ketones. The Journal of Organic Chemistry. 72: 626-9. PMID 17221983 DOI: 10.1021/Jo0616512  0.833
2007 Tanuwidjaja J, Peltier HM, Lewis JC, Schenkel LB, Ellman JA. One-pot microwave-promoted synthesis of nitriles from aldehydes via tert-butanesulfinyl imines Synthesis. 3385-3389. DOI: 10.1055/S-2007-990805  0.829
2007 Watzke A, Wilson RM, O'Malley SJ, Bergman RG, Ellman JA. Asymmetric intramolecular alkylation of chiral aromatic imines via catalytic C-H bond activation Synlett. 2383-2389. DOI: 10.1055/S-2007-985593  0.596
2007 Lewis JC, Bergman RG, Ellman JA. Rh-Catalyzed C-H Activation Route to 2-Alkylpyridines and 2-Alkylquinolines Synfacts. 2007: 806-806. DOI: 10.1055/S-2007-968795  0.509
2007 Bergman R, Ellman J, Rech J, Yato M, Duckett D, Ember B, LoGrasso P. Rh-Catalyzed C-H Activation Route to Bicyclic Imidazoles Synfacts. 2007: 0472-0472. DOI: 10.1055/S-2007-968478  0.516
2007 Bunin BA, Plunkett MJ, Ellman JA. 15 Synthesis and evaluation of three 1,4-benzodiazepine libraries Combinatorial Peptide and Nonpeptide Libraries: a Handbook. 405-424. DOI: 10.1002/9783527614912.ch15  0.797
2006 Peltier HM, McMahon JP, Patterson AW, Ellman JA. The total synthesis of tubulysin D. Journal of the American Chemical Society. 128: 16018-9. PMID 17165738 DOI: 10.1021/Ja067177Z  0.809
2006 Patterson AW, Wood WJ, Hornsby M, Lesley S, Spraggon G, Ellman JA. Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method. Journal of Medicinal Chemistry. 49: 6298-307. PMID 17034136 DOI: 10.1021/Jm060701S  0.794
2006 Watzke A, O'Malley SJ, Bergman RG, Ellman JA. Reassignment of the configuration of salvianolic acid B and establishment of its identity with lithospermic acid B. Journal of Natural Products. 69: 1231-3. PMID 16933885 DOI: 10.1021/Np060136W  0.773
2006 Patterson AW, Ellman JA. Asymmetric synthesis of alpha,alpha-dibranched propargylamines by acetylide additions to N-tert-butanesulfinyl ketimines. The Journal of Organic Chemistry. 71: 7110-2. PMID 16930078 DOI: 10.1021/Jo061160H  0.62
2006 Salisbury CM, Ellman JA. Rapid identification of potent nonpeptidic serine protease inhibitors. Chembiochem : a European Journal of Chemical Biology. 7: 1034-7. PMID 16708409 DOI: 10.1002/Cbic.200600081  0.734
2006 Beenen MA, Weix DJ, Ellman JA. Asymmetric synthesis of protected arylglycines by rhodium-catalyzed addition of arylboronic acids to N-tert-butanesulfinyl imino esters. Journal of the American Chemical Society. 128: 6304-5. PMID 16683780 DOI: 10.1021/Ja060529H  0.724
2006 Colby DA, Bergman RG, Ellman JA. Stereoselective alkylation of alpha,beta-unsaturated imines via C-H bond activation. Journal of the American Chemical Society. 128: 5604-5. PMID 16637605 DOI: 10.1021/Ja0584931  0.718
2006 Wilson RM, Thalji RK, Bergman RG, Ellman JA. Enantioselective synthesis of a PKC inhibitor via catalytic C-H bond activation. Organic Letters. 8: 1745-7. PMID 16597156 DOI: 10.1021/Ol060485H  0.829
2006 Gosalia DN, Denney WS, Salisbury CM, Ellman JA, Diamond SL. Functional phenotyping of human plasma using a 361-fluorogenic substrate biosensing microarray. Biotechnology and Bioengineering. 94: 1099-110. PMID 16575920 DOI: 10.1002/Bit.20927  0.735
2006 Choe Y, Leonetti F, Greenbaum DC, Lecaille F, Bogyo M, Brömme D, Ellman JA, Craik CS. Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities. The Journal of Biological Chemistry. 281: 12824-32. PMID 16520377 DOI: 10.1074/Jbc.M513331200  0.654
2006 Wiedemann SH, Ellman JA, Bergman RG. Rhodium-catalyzed direct C-H addition of 3,4-dihydroquinazolines to alkenes and their use in the total synthesis of vasicoline. The Journal of Organic Chemistry. 71: 1969-76. PMID 16496982 DOI: 10.1021/Jo052345B  0.592
2006 Wiedemann SH, Lewis JC, Ellman JA, Bergman RG. Experimental and computational studies on the mechanism of N-heterocycle C-H activation by Rh(I). Journal of the American Chemical Society. 128: 2452-62. PMID 16478202 DOI: 10.1021/Ja0576684  0.681
2006 Lewis JC, Wu JY, Bergman RG, Ellman JA. Microwave-promoted rhodium-catalyzed arylation of heterocycles through C--H bond activation. Angewandte Chemie (International Ed. in English). 45: 1589-91. PMID 16444794 DOI: 10.1002/Anie.200504289  0.676
2006 Bergman R, Ellman J, Colby D. Alkylation of α,β-Unsaturated Imines via C-H Bond Activation Synfacts. 2006: 0814-0814. DOI: 10.1055/S-2006-942012  0.729
2006 Ellman J, Beenen M, Weix D. Enantioselective Synthesis of Arylglycines from Arylboronic Acids Synfacts. 2006: 0716-0716. DOI: 10.1055/S-2006-941888  0.694
2006 Bergman R, Ellman J, Wilson R, Thalji R. Rhodium-Catalyzed Imine-Directed C-H Bond Functionalization Synfacts. 2006: 0586-0586. DOI: 10.1055/S-2006-934472  0.796
2006 Ellman J, Bergman R, Wiedemann S. Rh-Catalyzed C-H Addition of Quinazolines to Alkenes Synfacts. 2006: 0432-0432. DOI: 10.1055/S-2006-934374  0.513
2006 O’Malley SJ, Tan KL, Watzke A, Bergman RG, Ellman JA. Synthesis of (+)-Lithospermic Acid Synfacts. 2006: 98-98. DOI: 10.1055/S-2005-921780  0.497
2006 Zhang Y, Lewis JC, Bergman RG, Ellman JA, Oldfield E. NMR shifts, orbitals, and M⋯H-X bonding in d 8 square planar metal complexes Organometallics. 25: 3515-3519. DOI: 10.1021/Om060163H  0.605
2005 McMahon JP, Ellman JA. Asymmetric conjugate addition of copper reagents to alpha,beta-unsaturated tert-butanesulfinyl imines. Organic Letters. 7: 5393-6. PMID 16288514 DOI: 10.1021/Ol051986Q  0.694
2005 Wood WJ, Patterson AW, Tsuruoka H, Jain RK, Ellman JA. Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors. Journal of the American Chemical Society. 127: 15521-7. PMID 16262416 DOI: 10.1021/Ja0547230  0.805
2005 O'Malley SJ, Tan KL, Watzke A, Bergman RG, Ellman JA. Total synthesis of (+)-lithospermic acid by asymmetric intramolecular alkylation via catalytic C-H bond activation. Journal of the American Chemical Society. 127: 13496-7. PMID 16190703 DOI: 10.1021/Ja052680H  0.836
2005 Peltier HM, Ellman JA. N-sulfinyl metalloenamine conjugate additions: asymmetric synthesis of piperidines. The Journal of Organic Chemistry. 70: 7342-5. PMID 16122257 DOI: 10.1021/Jo051020S  0.825
2005 Thalji RK, Ahrendt KA, Bergman RG, Ellman JA. Annulation of aromatic imines via directed C-H bond activation. The Journal of Organic Chemistry. 70: 6775-81. PMID 16095296 DOI: 10.1021/Jo050757E  0.817
2005 Brinner KM, Ellman JA. A rapid and general method for the asymmetric synthesis of 2-substituted pyrrolidines using tert-butanesulfinamide. Organic & Biomolecular Chemistry. 3: 2109-13. PMID 15917897 DOI: 10.1039/B502080H  0.832
2005 Peltier HM, Evans JW, Ellman JA. Catalytic enantioselective sulfinyl transfer using cinchona alkaloid catalysts. Organic Letters. 7: 1733-6. PMID 15844893 DOI: 10.1021/Ol050275P  0.804
2005 Gosalia DN, Salisbury CM, Maly DJ, Ellman JA, Diamond SL. Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays. Proteomics. 5: 1292-8. PMID 15742319 DOI: 10.1002/Pmic.200401011  0.785
2005 Gosalia DN, Salisbury CM, Ellman JA, Diamond SL. High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays. Molecular & Cellular Proteomics : McP. 4: 626-36. PMID 15705970 DOI: 10.1074/Mcp.M500004-Mcp200  0.75
2005 Weix DJ, Shi Y, Ellman JA. Diastereoselective and enantioselective Rh(I)-catalyzed additions of arylboronic acids to N-tert-butanesulfinyl and N-diphenylphosphinoyl aldimines. Journal of the American Chemical Society. 127: 1092-3. PMID 15669835 DOI: 10.1021/Ja044003D  0.759
2005 Brinner KM, Powles MA, Schmatz DM, Ellman JA. Potent 4-aminopiperidine based antimalarial agents. Bioorganic & Medicinal Chemistry Letters. 15: 345-8. PMID 15603951 DOI: 10.1016/J.Bmcl.2004.10.069  0.772
2005 Lewis JC, Wu J, Bergman RG, Ellman JA. Preagostic Rh-H interactions and C-H bond functionalization: A Combined Experimental and Theoretical Investigation of Rhodium (I) Phosphinite Complexes Organometallics. 24: 5737-5746. DOI: 10.1021/Om050700I  0.628
2005 Brinner KM, Powles MA, Schmatz DM, Ellman JA. Corrigendum to “Potent 4-aminopiperidine based antimalarial agents” [Bioorg. Med. Chem. Lett. 15 (2005) 345] Bioorganic & Medicinal Chemistry Letters. 15: 3317. DOI: 10.1016/J.Bmcl.2005.04.069  0.76
2005 Brinner K, Ellman JA. Asymmetric Synthesis of β-Amino Acids by Enolate Additions to tert-Butanesulfinyl Imines Enantioselective Synthesis of β-Amino Acids: Second Edition. 181-194. DOI: 10.1002/0471698482.ch8  0.798
2005 Weix DJ, Ellman JA. (RS)‐(+)‐2‐Methyl‐2‐propanesulfinamide Organic Syntheses. 157-165. DOI: 10.1002/0471264229.Os082.24  0.642
2004 Kochi T, Ellman JA. Asymmetric alpha-alkylation of N'-tert-butanesulfinyl amidines. Application to the total synthesis of (6R,7S)-7-amino-7,8-dihydro-alpha-bisabolene. Journal of the American Chemical Society. 126: 15652-3. PMID 15571381 DOI: 10.1021/Ja044753N  0.579
2004 Tan KL, Park S, Ellman JA, Bergman RG. Intermolecular coupling of alkenes to heterocycles via C-H bond activation. The Journal of Organic Chemistry. 69: 7329-35. PMID 15471487 DOI: 10.1021/Jo048666P  0.549
2004 Schenkel LB, Ellman JA. Self-condensation of N-tert-butanesulfinyl aldimines: application to the rapid asymmetric synthesis of biologically important amine-containing compounds. Organic Letters. 6: 3621-4. PMID 15387563 DOI: 10.1021/Ol048458J  0.774
2004 Evans JW, Fierman MB, Miller SJ, Ellman JA. Catalytic enantioselective synthesis of sulfinate esters through the dynamic resolution of tert-butanesulfinyl chloride. Journal of the American Chemical Society. 126: 8134-5. PMID 15225052 DOI: 10.1021/Ja047845L  0.714
2004 Thalji RK, Ellman JA, Bergman RG. Highly efficient and enantioselective cyclization of aromatic imines via directed C-H bond activation. Journal of the American Chemical Society. 126: 7192-3. PMID 15186153 DOI: 10.1021/Ja0394986  0.824
2004 Wiedemann SH, Bergman RG, Ellman JA. Rhodium-catalyzed direct C-H addition of 4,4-dimethyl-2-oxazoline to alkenes. Organic Letters. 6: 1685-7. PMID 15128267 DOI: 10.1021/Ol049417Q  0.561
2004 McMahon JP, Ellman JA. Highly stereoselective addition of organometallic reagents to N-tert-butanesulfinyl imines derived from 3- and 4-substituted cyclohexanones. Organic Letters. 6: 1645-7. PMID 15128257 DOI: 10.1021/Ol0495220  0.757
2004 Schenkel LB, Ellman JA. Application of P,N-sulfinyl imine ligands to iridium-catalyzed asymmetric hydrogenation of olefins. The Journal of Organic Chemistry. 69: 1800-2. PMID 15058921 DOI: 10.1021/Jo035675+  0.742
2004 Lewis JC, Wiedemann SH, Bergman RG, Ellman JA. Arylation of heterocycles via rhodium-catalyzed C-H bond functionalization. Organic Letters. 6: 35-8. PMID 14703344 DOI: 10.1021/Ol035985E  0.7
2004 Kochi T, Mukade T, Ellman JA. Asymmetric Synthesis of Amines with tert-Butanesulfinamide and Its Application Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 62: 128-139. DOI: 10.5059/Yukigoseikyokaishi.62.128  0.635
2003 Kochi T, Tang TP, Ellman JA. Development and application of a new general method for the asymmetric synthesis of syn- and anti-1,3-amino alcohols. Journal of the American Chemical Society. 125: 11276-82. PMID 16220949 DOI: 10.1021/Ja0363462  0.787
2003 Evans JW, Ellman JA. Stereoselective synthesis of 1,2-disubstituted beta-amino alcohols by nucleophilic addition to N-tert-butanesulfinyl alpha-alkoxyaldimines. The Journal of Organic Chemistry. 68: 9948-57. PMID 14682687 DOI: 10.1021/Jo035224P  0.602
2003 Wood WJ, Huang L, Ellman JA. Synthesis of a diverse library of mechanism-based cysteine protease inhibitors. Journal of Combinatorial Chemistry. 5: 869-80. PMID 14606817 DOI: 10.1021/Cc034008R  0.749
2003 Boitano A, Emal CD, Leonetti F, Blatt NB, Dineen TA, Ellman JA, Roush WR, Opipari AW, Glick GD. Structure activity studies of a novel cytotoxic benzodiazepine. Bioorganic & Medicinal Chemistry Letters. 13: 3327-30. PMID 12951119 DOI: 10.1016/S0960-894X(03)00683-8  0.679
2003 Jain RK, Trias J, Ellman JA. D-Ala-D-lac binding is not required for the high activity of vancomycin dimers against vancomycin resistant enterococci. Journal of the American Chemical Society. 125: 8740-1. PMID 12862465 DOI: 10.1021/Ja0359761  0.517
2003 Tan KL, Vasudevan A, Bergman RG, Ellman JA, Souers AJ. Microwave-assisted C-H bond activation: a rapid entry into functionalized heterocycles. Organic Letters. 5: 2131-4. PMID 12790546 DOI: 10.1021/Ol030050J  0.726
2003 Weix DJ, Ellman JA. Improved synthesis of tert-butanesulfinamide suitable for large-scale production. Organic Letters. 5: 1317-20. PMID 12688748 DOI: 10.1021/Ol034254B  0.71
2003 Ahrendt KA, Bergman RG, Ellman JA. Synthesis of a tricyclic mescaline analogue by catalytic C-H bond activation. Organic Letters. 5: 1301-3. PMID 12688744 DOI: 10.1021/Ol034228D  0.581
2003 Bednarski JJ, Warner RE, Rao T, Leonetti F, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW, Glick GD. Attenuation of autoimmune disease in Fas-deficient mice by treatment with a cytotoxic benzodiazepine. Arthritis and Rheumatism. 48: 757-66. PMID 12632430 DOI: 10.1002/Art.10968  0.603
2003 Asojo OA, Gulnik SV, Afonina E, Yu B, Ellman JA, Haque TS, Silva AM. Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum. Journal of Molecular Biology. 327: 173-81. PMID 12614616 DOI: 10.1016/S0022-2836(03)00036-6  0.789
2003 Schenkel LB, Ellman JA. Novel sulfinyl imine ligands for asymmetric catalysis. Organic Letters. 5: 545-8. PMID 12583765 DOI: 10.1021/Ol027468M  0.736
2003 Leiting B, Pryor KD, Wu JK, Marsilio F, Patel RA, Craik CS, Ellman JA, Cummings RT, Thornberry NA. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. The Biochemical Journal. 371: 525-32. PMID 12529175 DOI: 10.1042/Bj20021643  0.304
2003 Blum SA, Bergman RG, Ellman JA. Enantioselective oxidation of di-tert-butyl disulfide with a vanadium catalyst: progress toward mechanism elucidation. The Journal of Organic Chemistry. 68: 150-5. PMID 12515473 DOI: 10.1021/Jo0205560  0.713
2003 Owens TD, Souers AJ, Ellman JA. The preparation and utility of bis(sulfinyl)imidoamidine ligands for the copper-catalyzed Diels-Alder reaction. The Journal of Organic Chemistry. 68: 3-10. PMID 12515453 DOI: 10.1021/Jo020524C  0.817
2003 Cawley NX, Chino M, Maldonado A, Rodriguez YM, Loh YP, Ellman JA. Synthesis and characterization of the first potent inhibitor of yapsin 1. Implications for the study of yapsin-like enzymes. The Journal of Biological Chemistry. 278: 5523-30. PMID 12468548 DOI: 10.1074/Jbc.M207230200  0.371
2003 Huang L, Brinen LS, Ellman JA. Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain. Bioorganic & Medicinal Chemistry. 11: 21-9. PMID 12467703 DOI: 10.1016/S0968-0896(02)00427-3  0.499
2003 Ellman JA. Applications of tert-butanesulfinamide in the asymmetric synthesis of amines Pure and Applied Chemistry. 75: 39-46. DOI: 10.1351/Pac200375010039  0.397
2003 Mukade T, Dragoli DR, Ellman JA. Parallel solution-phase asymmetric synthesis of α-branched amines Journal of Combinatorial Chemistry. 5: 590-596. DOI: 10.1021/Cc030016W  0.82
2002 Maly DJ, Huang L, Ellman JA. Combinatorial strategies for targeting protein families: application to the proteases. Chembiochem : a European Journal of Chemical Biology. 3: 16-37. PMID 17590950 DOI: 10.1002/1439-7633(20020104)3:1<16::Aid-Cbic16>3.0.Co;2-Z  0.677
2002 Salisbury CM, Maly DJ, Ellman JA. Peptide microarrays for the determination of protease substrate specificity. Journal of the American Chemical Society. 124: 14868-70. PMID 12475327 DOI: 10.1021/Ja027477Q  0.792
2002 Tan KL, Bergman RG, Ellman JA. Intermolecular coupling of isomerizable alkenes to heterocycles via rhodium-catalyzed C-H bond activation. Journal of the American Chemical Society. 124: 13964-5. PMID 12440873 DOI: 10.1021/Ja0281129  0.562
2002 Ellman JA, Owens TD, Tang TP. N-tert-butanesulfinyl imines: versatile intermediates for the asymmetric synthesis of amines. Accounts of Chemical Research. 35: 984-95. PMID 12437323 DOI: 10.1021/Ar020066U  0.818
2002 Tang TP, Ellman JA. Asymmetric synthesis of beta-amino acid derivatives incorporating a broad range of substitution patterns by enolate additions to tert-butanesulfinyl imines. The Journal of Organic Chemistry. 67: 7819-32. PMID 12398509 DOI: 10.1021/Jo025957U  0.675
2002 Blatt NB, Bednarski JJ, Warner RE, Leonetti F, Johnson KM, Boitano A, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW, Glick GD. Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. The Journal of Clinical Investigation. 110: 1123-32. PMID 12393848 DOI: 10.1172/Jci16029  0.618
2002 Huang L, Ellman JA. General solid-phase method to prepare novel cyclic ketone inhibitors of the cysteine protease cruzain. Bioorganic & Medicinal Chemistry Letters. 12: 2993-6. PMID 12270191 DOI: 10.1016/S0960-894X(02)00619-4  0.552
2002 Brinner KM, Mi Kim J, Habashita H, Gluzman IY, Goldberg DE, Ellman JA. Novel and potent anti-malarial agents. Bioorganic & Medicinal Chemistry. 10: 3649-61. PMID 12213481 DOI: 10.1016/S0968-0896(02)00207-9  0.774
2002 Choi CY, Schneider EL, Kim JM, Gluzman IY, Goldberg DE, Ellman JA, Marletta MA. Interference with heme binding to histidine-rich protein-2 as an antimalarial strategy. Chemistry & Biology. 9: 881-9. PMID 12204687 DOI: 10.1016/S1074-5521(02)00183-7  0.395
2002 Wang X, Choe Y, Craik CS, Ellman JA. Design and synthesis of novel inhibitors of gelatinase B. Bioorganic & Medicinal Chemistry Letters. 12: 2201-4. PMID 12127537 DOI: 10.1016/S0960-894X(02)00365-7  0.555
2002 Kochi T, Tang TP, Ellman JA. Asymmetric synthesis of syn- and anti-1,3-amino alcohols. Journal of the American Chemical Society. 124: 6518-9. PMID 12047156 DOI: 10.1021/Ja026292G  0.776
2002 Tan KL, Bergman RG, Ellman JA. Intermediacy of an N-heterocyclic carbene complex in the catalytic C-H activation of a substituted benzimidazole. Journal of the American Chemical Society. 124: 3202-3. PMID 11916392 DOI: 10.1021/Ja017351D  0.561
2002 Maly DJ, Leonetti F, Backes BJ, Dauber DS, Harris JL, Craik CS, Ellman JA. Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore. The Journal of Organic Chemistry. 67: 910-5. PMID 11856036 DOI: 10.1021/Jo016140O  0.816
2002 Kehoe JW, Maly DJ, Verdugo DE, Armstrong JI, Cook BN, Ouyang YB, Moore KL, Ellman JA, Bertozzi CR. Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly. Bioorganic & Medicinal Chemistry Letters. 12: 329-32. PMID 11814789 DOI: 10.1016/S0960-894X(01)00744-2  0.584
2002 Huang L, Lee A, Ellman JA. Identification of potent and selective mechanism-based inhibitors of the cysteine protease cruzain using solid-phase parallel synthesis. Journal of Medicinal Chemistry. 45: 676-84. PMID 11806719 DOI: 10.1021/Jm010333M  0.626
2002 Dauber DS, Ziermann R, Parkin N, Maly DJ, Mahrus S, Harris JL, Ellman JA, Petropoulos C, Craik CS. Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease. Journal of Virology. 76: 1359-68. PMID 11773410 DOI: 10.1128/Jvi.76.3.1359-1368.2002  0.538
2001 Szewczyk JW, Zuckerman RL, Bergman RG, Ellman JA. A Mass Spectrometric Labeling Strategy for High-Throughput Reaction Evaluation and Optimization: Exploring C-H Activation. Angewandte Chemie (International Ed. in English). 40: 216-219. PMID 29711936 DOI: 10.1002/1521-3773(20010105)40:1<216::Aid-Anie216>3.0.Co;2-K  0.795
2001 Tang TP, Volkman SK, Ellman JA. Asymmetric synthesis of protected 1,2-amino alcohols using tert-butanesulfinyl aldimines and ketimines. The Journal of Organic Chemistry. 66: 8772-8. PMID 11749605 DOI: 10.1021/Jo0156868  0.743
2001 Lee A, Ellman JA. Parallel solution-phase synthesis of mechanism-based cysteine protease inhibitors. Organic Letters. 3: 3707-9. PMID 11700118 DOI: 10.1021/Ol0166496  0.541
2001 Dragoli DR, Burdett MT, Ellman JA. Design, synthesis, and utility of a support-bound tert-butanesulfinamide. Journal of the American Chemical Society. 123: 10127-8. PMID 11592904 DOI: 10.1021/Ja016349J  0.792
2001 Thalji RK, Ahrendt KA, Bergman RG, Ellman JA. Annulation of aromatic imines via directed C-H activation with Wilkinson's catalyst. Journal of the American Chemical Society. 123: 9692-3. PMID 11572698 DOI: 10.1021/Ja016642J  0.789
2001 Souers AJ, Owens TD, Oliver AG, Hollander FJ, Ellman JA. Synthesis and crystal structure of a unique and homochiral N,S-bonded N,N'-bis(tert-butanesulfinyl)amidinate rhodium(I) complex. Inorganic Chemistry. 40: 5299-301. PMID 11559098 DOI: 10.1021/Ic0104205  0.796
2001 Tan KL, Bergman RG, Ellman JA. Annulation of alkenyl-substituted heterocycles via rhodium-catalyzed intramolecular C-H activated coupling reactions. Journal of the American Chemical Society. 123: 2685-6. PMID 11456947 DOI: 10.1021/ja0058738  0.49
2001 Harris JL, Niles A, Burdick K, Maffitt M, Backes BJ, Ellman JA, Kuntz I, Haak-Frendscho M, Craik CS. Definition of the extended substrate specificity determinants for beta-tryptases I and II. The Journal of Biological Chemistry. 276: 34941-7. PMID 11438529 DOI: 10.1074/Jbc.M102997200  0.648
2001 Szewczyk JW, Zuckerman RL, Bergman RG, Ellman JA. A Mass Spectrometric Labeling Strategy for High-Throughput Reaction Evaluation and Optimization: Exploring C-H Activation This work was supported by the Director, Office of Energy Research, Office of Basic Energy Sciences, Chemical Sciences Division, U.S. Department of Energy, under contract No. DE-AC03-76SF00098. We are grateful to the National Institutes of Health for support (GM-50353) and for a Postdoctoral Fellowship to J.W.S. Angewandte Chemie (International Ed. in English). 40: 216-219. PMID 11169717 DOI: 10.1002/1521-3773(20010105)40:1<216::Aid-Anie216>3.3.Co;2-B  0.776
2001 Owens TD, Hollander FJ, Oliver AG, Ellman JA. Synthesis, utility, and structure of novel bis(sulfinyl)imidoamidine ligands for asymmetric Lewis acid catalysis [21] Journal of the American Chemical Society. 123: 1539-1540. DOI: 10.1021/Ja005635C  0.746
2001 Borg G, Chino M, Ellman JA. Asymmetric synthesis of pre-protected α,α-disubstituted amino acids from tert-butanesulfinyl ketimines Tetrahedron Letters. 42: 1433-1436. DOI: 10.1016/S0040-4039(00)02300-5  0.719
2001 Souers AJ, Ellman JA. β-Turn mimetic library synthesis: Scaffolds and applications Tetrahedron. 57: 7431-7448. DOI: 10.1016/S0040-4020(01)00680-9  0.621
2000 Souers AJ, Rosenquist A, Jarvie EM, Ladlow M, Feniuk W, Ellman JA. Optimization of a somatostatin mimetic via constrained amino acid and backbone incorporation. Bioorganic & Medicinal Chemistry Letters. 10: 2731-3. PMID 11133079 DOI: 10.1016/S0960-894X(00)00552-7  0.631
2000 Harris JL, Backes BJ, Leonetti F, Mahrus S, Ellman JA, Craik CS. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries. Proceedings of the National Academy of Sciences of the United States of America. 97: 7754-9. PMID 10869434 DOI: 10.1073/Pnas.140132697  0.786
2000 Souers AJ, Ellman JA. Asymmetric synthesis of a C-3 substituted pipecolic acid. The Journal of Organic Chemistry. 65: 1222-4. PMID 10814077 DOI: 10.1021/Jo991293L  0.684
2000 Bi X, Haque TS, Zhou J, Skillman AG, Lin B, Lee CE, Kuntz ID, Ellman JA, Lynch G. Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus. Journal of Neurochemistry. 74: 1469-77. PMID 10737603 DOI: 10.1046/J.1471-4159.2000.0741469.X  0.787
2000 Maly DJ, Choong IC, Ellman JA. Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 97: 2419-24. PMID 10716979 DOI: 10.1073/Pnas.97.6.2419  0.787
2000 Backes BJ, Harris JL, Leonetti F, Craik CS, Ellman JA. Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin. Nature Biotechnology. 18: 187-93. PMID 10657126 DOI: 10.1038/72642  0.769
2000 Backes BJ, Harris JL, Leonetti F, Craik CS, Ellman JA. Erratum: Erratum to “Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin” Nature Biotechnology. 18: 559-559. DOI: 10.1038/75441  0.616
1999 Choong IC, Ellman JA. Synthesis of Alkoxylamines by Alkoxide Amination with 3,3'-Di-tert-butyloxaziridine. The Journal of Organic Chemistry. 64: 6528-6529. PMID 11674653 DOI: 10.1021/Jo990490H  0.803
1999 Backes BJ, Dragoli DR, Ellman JA. Chiral N-Acyl-tert-butanesulfinamides: The "Safety-Catch" Principle Applied to Diastereoselective Enolate Alkylations. The Journal of Organic Chemistry. 64: 5472-5478. PMID 11674609 DOI: 10.1021/Jo990271W  0.821
1999 Tang TP, Ellman JA. The tert-Butanesulfinyl Group: An Ideal Chiral Directing Group and Boc-Surrogate for the Asymmetric Synthesis and Applications of beta-Amino Acids. The Journal of Organic Chemistry. 64: 12-13. PMID 11674077 DOI: 10.1021/Jo9820824  0.713
1999 Dragoli DR, Thompson LA, O'Brien J, Ellman JA. Parallel synthesis of prostaglandin E1 analogues. Journal of Combinatorial Chemistry. 1: 534-9. PMID 10748730 DOI: 10.1021/Cc990033E  0.805
1999 Haskell-Luevano C, Rosenquist A, Souers A, Khong KC, Ellman JA, Cone RD. Compounds that activate the mouse melanocortin-1 receptor identified by screening a small molecule library based upon the beta-turn. Journal of Medicinal Chemistry. 42: 4380-7. PMID 10543881 DOI: 10.1021/Jm990190S  0.565
1999 Ramdas L, Bunnin BA, Plunkett MJ, Sun G, Ellman J, Gallick GE, Budde RJA. Benzodiazepine Compounds As Inhibitors Of The Src Protein Tyrosine Kinase : Screening Of A Combinatorial Library Of 1,4-Benzodiazepines Archives of Biochemistry and Biophysics. 368: 394-400. PMID 10441393 DOI: 10.1006/Abbi.1999.1313  0.338
1999 Haque TS, Skillman AG, Lee CE, Habashita H, Gluzman IY, Ewing TJ, Goldberg DE, Kuntz ID, Ellman JA. Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II. Journal of Medicinal Chemistry. 42: 1428-40. PMID 10212129 DOI: 10.1021/Jm980641T  0.789
1999 Souers AJ, Schürer S, Kwack H, Virgilio AA, Ellman JA. Preparation of Enantioenriched α-Bromo Acids Incorporating Diverse Functionality Synthesis. 1999: 583-585. DOI: 10.1055/S-1999-3427  0.628
1999 Liu G, Cogan DA, Owens TD, Tang TP, Ellman JA. Synthesis of enantiomerically pure N-tert-butanesulfinyl imines (tert- butanesulfinimines) by the direct condensation of tert-butanesulfinamide with aldehydes and ketones Journal of Organic Chemistry. 64: 1278-1284. DOI: 10.1021/Jo982059I  0.827
1999 Backes BJ, Ellman JA. An alkanesulfonamide 'safety-catch' linker for solid-phase synthesis Journal of Organic Chemistry. 64: 2322-2330. DOI: 10.1021/Jo981990Y  0.725
1999 Lee A, Huang L, Ellman JA. General Solid-Phase Method for the Preparation of Mechanism-Based Cysteine Protease Inhibitors Journal of the American Chemical Society. 121: 9907-9914. DOI: 10.1021/Ja992009A  0.68
1999 Souers AJ, Virgilio AA, Rosenquist Å, Fenuik W, Ellman JA. Identification of a potent heterocyclic ligand to somatostatin receptor subtype 5 by the synthesis and screening of β-turn mimetic libraries Journal of the American Chemical Society. 121: 1817-1825. DOI: 10.1021/Ja983742P  0.653
1999 Borg G, Cogan DA, Ellman JA. One-pot asymmetric synthesis of tert-butanesulfinyl-protected amines from ketones by the in situ reduction of tert-butanesulfinyl ketimines Tetrahedron Letters. 40: 6709-6712. DOI: 10.1016/S0040-4039(99)01351-9  0.749
1999 Cogan DA, Liu G, Ellman J. Asymmetric synthesis of chiral amines by highly diastereoselective 1,2-additions of organometallic reagents to N-tert -Butanesulfinyl Imines Tetrahedron. 55: 8883-8904. DOI: 10.1016/S0040-4020(99)00451-2  0.439
1998 Souers AJ, Virgilio AA, Schürer SS, Ellman JA, Kogan TP, West HE, Ankener W, Vanderslice P. Novel inhibitors of alpha 4 beta 1 integrin receptor interactions through library synthesis and screening. Bioorganic & Medicinal Chemistry Letters. 8: 2297-302. PMID 9873531 DOI: 10.1016/S0960-894X(98)00416-8  0.599
1998 Ellman JA, Gallop MA. Combinatorial chemistry. Current Opinion in Chemical Biology. 2: 317-9. PMID 9722909 DOI: 10.1016/s1367-5931(98)80003-3  0.607
1998 Cogan DA, Liu G, Kim K, Backes BJ, Ellman JA. Catalytic asymmetric oxidation of tert-butyl disulfide. Synthesis of tert-butanesulfinamides, tert-butyl sulfoxides, and tert-butanesulfinimines Journal of the American Chemical Society. 120: 8011-8019. DOI: 10.1021/Ja9809206  0.729
1997 Plunkett MJ, Ellman JA. Germanium and Silicon Linking Strategies for Traceless Solid-Phase Synthesis. The Journal of Organic Chemistry. 62: 2885-2893. PMID 11671652 DOI: 10.1021/Jo961889Y  0.806
1997 Backes BJ, Ellman JA. Solid support linker strategies. Current Opinion in Chemical Biology. 1: 86-93. PMID 9667836 DOI: 10.1016/S1367-5931(97)80113-5  0.689
1997 Kick EK, Roe DC, Skillman AG, Liu G, Ewing TJ, Sun Y, Kuntz ID, Ellman JA. Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D. Chemistry & Biology. 4: 297-307. PMID 9195867 DOI: 10.1016/S1074-5521(97)90073-9  0.79
1997 Plunkett MJ, Ellman JA. Combinatorial chemistry and new drugs. Scientific American. 276: 68-73. PMID 9092072 DOI: 10.1038/Scientificamerican0497-68  0.752
1997 Boojamra CG, Burow KM, Thompson LA, Ellman JA. Solid-Phase Synthesis of 1,4-Benzodiazepine-2,5-diones. Library Preparation and Demonstration of Synthesis Generality Journal of Organic Chemistry. 62: 1240-1256. DOI: 10.1021/Jo9622845  0.438
1997 Evans DA, Barrow JC, Watson PS, Ratz AM, Dinsmore CJ, Evrard DA, DeVries KM, Ellman JA, Rychnovsky SD, Lacour J. Approaches to the synthesis of the vancomycin antibiotics. Synthesis of orienticin C (bis-dechlorovancomycin) aglycon Journal of the American Chemical Society. 119: 3419-3420. DOI: 10.1021/Ja964420T  0.795
1996 Thompson LA, Ellman JA. Synthesis and Applications of Small Molecule Libraries. Chemical Reviews. 96: 555-600. PMID 11848765 DOI: 10.1021/Cr9402081  0.704
1996 Bunin BA, Plunkett MJ, Ellman JA. Synthesis and evaluation of 1,4-benzodiazepine libraries. Methods in Enzymology. 267: 448-65. PMID 8743332 DOI: 10.1016/S0076-6879(96)67028-1  0.804
1996 Stevens SY, Bunin BA, Plunkett MJ, Swanson PC, Ellman JA, Glick GD. Non nucleic acid inhibitors of protein·DNA interactions identified through combinatorial chemistry Journal of the American Chemical Society. 118: 10650-10651. DOI: 10.1021/Ja962452A  0.781
1996 Backes BJ, Virgilio AA, Ellman JA. Activation Method to Prepare a Highly Reactive Acylsulfonamide “Safety-Catch” Linker for Solid-Phase Synthesis1 Journal of the American Chemical Society. 118: 3055-3056. DOI: 10.1021/Ja9535165  0.666
1995 Kick EK, Ellman JA. Expedient method for the solid-phase synthesis of aspartic acid protease inhibitors directed toward the generation of libraries. Journal of Medicinal Chemistry. 38: 1427-30. PMID 7739000 DOI: 10.1021/Jm00009A002  0.788
1995 Plunkett MJ, Ellman JA. A Silicon-Based Linker for Traceless Solid-Phase Synthesis The Journal of Organic Chemistry. 60: 6006-6007. DOI: 10.1021/Jo00124A005  0.772
1995 Plunkett MJ, Ellman JA. Solid-Phase Synthesis of Structurally Diverse 1,4-Benzodiazepine Derivatives Using the Stille Coupling Reaction Journal of the American Chemical Society. 117: 3306-3307. DOI: 10.1021/Ja00116A049  0.794
1995 Cook SN, Jack WE, Xiong X, Danley LE, Ellman JA, Schultz PG, Noren CJ. Photochemically Initiated Protein Splicing Angewandte Chemie International Edition in English. 34: 1629-1630. DOI: 10.1002/Anie.199516291  0.691
1995 Cook SN, Jack WE, Xiong X, Noren CJ, Danley LE, Ellman JA, Schultz PG. Photochemisch induziertes Proteinspleißen Angewandte Chemie. 107: 1736-1737. DOI: 10.1002/Ange.19951071516  0.714
1994 Bunin BA, Plunkett MJ, Ellman JA. The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library. Proceedings of the National Academy of Sciences of the United States of America. 91: 4708-12. PMID 8197123 DOI: 10.1073/Pnas.91.11.4708  0.812
1994 Backes BJ, Ellman JA. Carbon-Carbon Bond-Forming Methods on Solid Support. Utilization of Kenner's "Safety-Catch" Linker Journal of the American Chemical Society. 116: 11171-11172. DOI: 10.1021/Ja00103A048  0.647
1993 Mendel D, Ellman J, Schultz PG. Protein biosynthesis with conformationally restricted amino acids Journal of the American Chemical Society. 115: 4359-4360. DOI: 10.1021/Ja00063A063  0.731
1992 Mendel D, Ellman JA, Chang Z, Veenstra DL, Kollman PA, Schultz PG. Probing protein stability with unnatural amino acids. Science (New York, N.Y.). 256: 1798-802. PMID 1615324 DOI: 10.1126/Science.1615324  0.726
1992 Ellman JA, Mendel D, Schultz PG. Site-specific incorporation of novel backbone structures into proteins. Science (New York, N.Y.). 255: 197-200. PMID 1553546 DOI: 10.1126/Science.1553546  0.74
1992 Bunin BA, Ellman JA. A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives Journal of the American Chemical Society. 114: 10997-10998. DOI: 10.1021/Ja00053A067  0.723
1992 Ellman JA, Volkman BF, Mendel D, Schulz PG, Wemmer DE. Site-specific isotopic labeling of proteins for NMR studies Journal of the American Chemical Society. 114: 7959-7961. DOI: 10.1021/Ja00046A080  0.697
1991 Mendel D, Ellman JA, Schultz PG. Construction of a light-activated protein by unnatural amino acid mutagenesis Journal of the American Chemical Society. 113: 2758-2760. DOI: 10.1021/Ja00007A063  0.721
1991 Robertson SA, Ellman JA, Schultz PG. A general and efficient route for chemical aminoacylation of transfer RNAs Journal of the American Chemical Society. 113: 2722-2729. DOI: 10.1021/Ja00007A055  0.551
1990 Evans DA, Britton TC, Ellman JA, Dorow RL. The asymmetric synthesis of .alpha.-amino acids. Electrophilic azidation of chiral imide enolates, a practical approach to the synthesis of (R)- and (S)-.alpha.-azido carboxylic acids Journal of the American Chemical Society. 112: 4011-4030. DOI: 10.1021/Ja00166A045  0.474
1989 Evans DA, Ellman JA, DeVries KM. The oxidative macrocyclization of phenolic peptides. A biomimetic approach to the synthesis of the vancomycin family of antibiotics Journal of the American Chemical Society. 111: 8912-8914. DOI: 10.1021/Ja00206A021  0.421
1989 Evans DA, Ellman JA. The total syntheses of the isodityrosine-derived cyclic tripeptides OF4949-III and K-13. Determination of the absolute configuration of K-13 Journal of the American Chemical Society. 111: 1063-1072. DOI: 10.1021/Ja00185A042  0.435
1987 Evans DA, Ellman JA, Dorow RL. Asymmetric halogenation of chiral imide enolates. A general approach to the synthesis of enantiomerically pure α-amino acids. Tetrahedron Letters. 28: 1123-1126. DOI: 10.1016/S0040-4039(00)95305-X  0.495
1987 Evans DA, Britton TC, Ellman JA. Contrasteric carboximide hydrolysis with lithium hydroperoxide Tetrahedron Letters. 28: 6141-6144. DOI: 10.1016/S0040-4039(00)61830-0  0.499
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