Eric T. Kool - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
Area:
chemical biology
Website:
http://www.stanford.edu/group/kool/kool.htm

240 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 McPherson LA, Troccoli CI, Ji D, Bowles AE, Gardiner ML, Mohsen MG, Nagathihalli NS, Nguyen DM, Robbins DJ, Merchant NB, Kool ET, Rai P, Ford JM. Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue. Dna Repair. 102644. PMID 31311767 DOI: 10.1016/j.dnarep.2019.102644  0.48
2019 Habibian M, Velema WA, Kietrys AM, Onishi Y, Kool ET. Polyacetate and Polycarbonate RNA: Acylating Reagents and Properties. Organic Letters. PMID 31268332 DOI: 10.1021/acs.orglett.9b01526  0.48
2019 Mohsen MG, Ji D, Kool ET. Polymerase-amplified release of ATP (POLARA) for detecting single nucleotide variants in RNA and DNA. Chemical Science. 10: 3264-3270. PMID 30996911 DOI: 10.1039/c8sc03901a  0.48
2019 Park HS, Kietrys AM, Kool ET. Simple alkanoyl acylating agents for reversible RNA functionalization and control. Chemical Communications (Cambridge, England). PMID 30977472 DOI: 10.1039/c9cc01598a  0.48
2019 Sun L, Fazal FM, Li P, Broughton JP, Lee B, Tang L, Huang W, Kool ET, Chang HY, Zhang QC. RNA structure maps across mammalian cellular compartments. Nature Structural & Molecular Biology. PMID 30886404 DOI: 10.1038/s41594-019-0200-7  0.4
2018 Larsen D, Kietrys AM, Clark SA, Park HS, Ekebergh A, Kool ET. Exceptionally rapid oxime and hydrazone formation promoted by catalytic amine buffers with low toxicity. Chemical Science. 9: 5252-5259. PMID 29997880 DOI: 10.1039/c8sc01082j  0.48
2018 Ji D, Kietrys AM, Lee Y, Kool ET. An ATP-linked Chimeric Nucleotide as a Specific Luminescence Reporter of Deoxyuridine Triphosphatase. Bioconjugate Chemistry. PMID 29578692 DOI: 10.1021/acs.bioconjchem.8b00124  0.48
2018 Velema WA, Kietrys AM, Kool ET. RNA Control by Photoreversible Acylation. Journal of the American Chemical Society. PMID 29474085 DOI: 10.1021/jacs.7b12408  0.48
2018 Tahara YK, Auld D, Ji D, Beharry AA, Kietrys AM, Wilson DL, Jimenez M, King D, Nguyen Z, Kool ET. Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase (OGG1). Journal of the American Chemical Society. PMID 29376367 DOI: 10.1021/jacs.7b09316  0.48
2018 Kadina A, Kietrys AM, Kool ET. RNA Cloaking by Reversible Acylation. Angewandte Chemie (International Ed. in English). PMID 29370460 DOI: 10.1002/anie.201708696  0.48
2017 Kietrys AM, Velema WAA, Kool ET. Fingerprints of Modified RNA Bases from Deep Sequencing Profiles. Journal of the American Chemical Society. PMID 29111692 DOI: 10.1021/jacs.7b07914  0.48
2017 Xu W, Chan KM, Kool ET. Fluorescent nucleobases as tools for studying DNA and RNA. Nature Chemistry. 9: 1043-1055. PMID 29064490 DOI: 10.1038/nchem.2859  0.72
2017 Ji D, Stepchenkova EI, Cui J, Menezes MR, Pavlov YI, Kool ET. Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera. Nucleic Acids Research. PMID 29036687 DOI: 10.1093/nar/gkx774  0.48
2017 Chan KM, Xu W, Kwon H, Kietrys AM, Kool ET. Luminescent Carbon Dot Mimics Assembled on DNA. Journal of the American Chemical Society. PMID 28841010 DOI: 10.1021/jacs.7b07420  0.72
2017 Kölmel DK, Kool ET. Oximes and Hydrazones in Bioconjugation: Mechanism and Catalysis. Chemical Reviews. PMID 28640998 DOI: 10.1021/acs.chemrev.7b00090  0.72
2017 Chan KM, Kölmel DK, Wang S, Kool ET. Color-Change Photoswitching of an Alkynylpyrene Excimer Dye. Angewandte Chemie (International Ed. in English). PMID 28474388 DOI: 10.1002/anie.201701235  1
2017 Kwon H, Chan KM, Kool ET. DNA as an environmental sensor: detection and identification of pesticide contaminants in water with fluorescent nucleobases. Organic & Biomolecular Chemistry. PMID 28150837 DOI: 10.1039/c6ob02830f  0.72
2017 Singh V, Wang S, Chan KM, Clark SA, Kool ET. Correction to "Genetically Encoded Multispectral Labeling of Proteins with Polyfluorophores on a DNA Backbone". Journal of the American Chemical Society. PMID 28128555 DOI: 10.1021/jacs.6b11085  1
2017 Harcourt EM, Kietrys AM, Kool ET. Chemical and structural effects of base modifications in messenger RNA. Nature. 541: 339-346. PMID 28102265 DOI: 10.1038/nature21351  0.48
2016 Clark SA, Singh V, Vega Mendoza D, Margolin W, Kool ET. Light-Up "Channel Dyes" for Haloalkane-Based Protein Labeling in Vitro and in Bacterial Cells. Bioconjugate Chemistry. 27: 2839-2843. PMID 27998074 DOI: 10.1021/acs.bioconjchem.6b00613  0.4
2016 Lee B, Flynn RA, Kadina A, Guo JK, Kool ET, Chang HY. Comparison of SHAPE Reagents for Mapping RNA Structures Inside Living Cells. Rna (New York, N.Y.). PMID 27879433 DOI: 10.1261/rna.058784.116  0.4
2016 Kent T, Rusanov TD, Hoang TM, Velema WA, Krueger AT, Copeland WC, Kool ET, Pomerantz RT. DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides. Nucleic Acids Research. PMID 27591252 DOI: 10.1093/nar/gkw721  0.88
2016 Ji D, Beharry AA, Ford JM, Kool ET. A Chimeric ATP-linked Nucleotide Enables Luminescence Signaling of Damage Surveillance by MTH1, a Cancer Target. Journal of the American Chemical Society. PMID 27413803 DOI: 10.1021/jacs.6b02895  1
2016 Yuen LH, Saxena NS, Weinberg K, Park HS, Kool ET. Dark Hydrazone Fluorescence Labeling Agents Enable Imaging of Cellular Aldehydic Load. Acs Chemical Biology. PMID 27326450 DOI: 10.1021/acschembio.6b00269  0.48
2016 Kölmel DK, Barandun LJ, Kool ET. Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores. Organic & Biomolecular Chemistry. PMID 27296353 DOI: 10.1039/c6ob01199c  0.72
2016 Hwang CS, Xu L, Wang W, Ulrich S, Zhang L, Chong J, Shin JH, Huang X, Kool ET, McKenna CE, Wang D. Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. Nucleic Acids Research. PMID 27060150 DOI: 10.1093/nar/gkw220  1
2016 Oertell K, Harcourt EM, Mohsen MG, Petruska J, Kool ET, Goodman MF. Kinetic selection vs. free energy of DNA base pairing in control of polymerase fidelity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27044101 DOI: 10.1073/pnas.1600279113  1
2016 Kietrys AM, Kool ET. Epigenetics: A new methyl mark on messengers. Nature. 530: 423-4. PMID 26911777 DOI: 10.1038/530423a  0.48
2016 Flynn RA, Do BT, Rubin AJ, Calo E, Lee B, Kuchelmeister H, Rale M, Chu C, Kool ET, Wysocka J, Khavari PA, Chang HY. 7SK-BAF axis controls pervasive transcription at enhancers. Nature Structural & Molecular Biology. PMID 26878240 DOI: 10.1038/nsmb.3176  0.4
2016 Ji D, Mohsen MG, Harcourt EM, Kool ET. ATP-Releasing Nucleotides: Linking DNA Synthesis to Luciferase Signaling. Angewandte Chemie (International Ed. in English). 55: 2087-91. PMID 26836342 DOI: 10.1002/anie.201509131  1
2015 Kwon H, Jiang W, Kool ET. Correction: Pattern-based detection of anion pollutants in water with DNA polyfluorophores. Chemical Science. 6: 5086. PMID 30123454 DOI: 10.1039/c5sc90036k  0.48
2015 Spitale RC, Flynn RA, Zhang QC, Crisalli P, Lee B, Jung JW, Kuchelmeister HY, Batista PJ, Torre EA, Kool ET, Chang HY. Erratum: Structural imprints in vivo decode RNA regulatory mechanisms. Nature. PMID 26416736 DOI: 10.1038/nature15717  0.48
2015 Karmakar S, Harcourt EM, Hewings DS, Lovejoy AF, Kurtz DM, Ehrenschwender T, Barandun LJ, Roost C, Alizadeh AA, Kool ET. Organocatalytic removal of formaldehyde adducts from RNA and DNA bases. Nature Chemistry. 7: 752-8. PMID 26291948 DOI: 10.1038/nchem.2307  1
2015 Kwon H, Jiang W, Kool ET. Pattern-Based Detection of Anion Pollutants in Water with DNA Polyfluorophores. Chemical Science (Royal Society of Chemistry : 2010). 6: 2575-2583. PMID 26146537 DOI: 10.1039/C4SC03992K  0.48
2015 Yuen LH, Franzini RM, Tan SS, Kool ET. Correction to "Large-Scale Detection of Metals with a Small Set of Fluorescent DNA-Like Chemosensors". Journal of the American Chemical Society. 137: 8309. PMID 26088103 DOI: 10.1021/jacs.5b05859  1
2015 Roost C, Lynch SR, Batista PJ, Qu K, Chang HY, Kool ET. Correction to "Structure and Thermodynamics of N(6)-Methyladenosine in RNA: A Spring-Loaded Base Modification". Journal of the American Chemical Society. PMID 26087989 DOI: 10.1021/jacs.5b05858  1
2015 Edwards SK, Ono T, Wang S, Jiang W, Franzini RM, Jung JW, Chan KM, Kool ET. In Vitro Fluorogenic Real-Time Assay of the Repair of Oxidative DNA Damage. Chembiochem : a European Journal of Chemical Biology. 16: 1637-46. PMID 26073452 DOI: 10.1002/cbic.201500184  1
2015 Spitale RC, Flynn RA, Zhang QC, Crisalli P, Lee B, Jung JW, Kuchelmeister HY, Batista PJ, Torre EA, Kool ET, Chang HY. Structural imprints in vivo decode RNA regulatory mechanisms. Nature. 519: 486-90. PMID 25799993 DOI: 10.1038/nature14263  1
2015 Roost C, Lynch SR, Batista PJ, Qu K, Chang HY, Kool ET. Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification. Journal of the American Chemical Society. 137: 2107-15. PMID 25611135 DOI: 10.1021/ja513080v  1
2015 Larsen D, Pittelkow M, Karmakar S, Kool ET. New organocatalyst scaffolds with high activity in promoting hydrazone and oxime formation at neutral pH. Organic Letters. 17: 274-7. PMID 25545888 DOI: 10.1021/ol503372j  1
2015 Kwon H, Jiang W, Kool ET. Pattern-based detection of anion pollutants in water with DNA polyfluorophores Chemical Science. 6: 2575-2583. DOI: 10.1039/c4sc03992k  1
2014 Yuen LH, Franzini RM, Tan SS, Kool ET. Large-scale detection of metals with a small set of fluorescent DNA-like chemosensors. Journal of the American Chemical Society. 136: 14576-82. PMID 25255102 DOI: 10.1021/ja507932a  1
2014 Spitale RC, Flynn RA, Torre EA, Kool ET, Chang HY. RNA structural analysis by evolving SHAPE chemistry. Wiley Interdisciplinary Reviews. Rna. 5: 867-81. PMID 25132067 DOI: 10.1002/wrna.1253  1
2014 Yuen LH, Franzini RM, Wang S, Crisalli P, Singh V, Jiang W, Kool ET. Pattern-based detection of toxic metals in surface water with DNA polyfluorophores. Angewandte Chemie (International Ed. in English). 53: 5361-5. PMID 24756982 DOI: 10.1002/anie.201403235  1
2014 Xu L, Butler KV, Chong J, Wengel J, Kool ET, Wang D. Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues. Nucleic Acids Research. 42: 5863-70. PMID 24692664 DOI: 10.1093/nar/gku238  1
2014 Kool ET, Crisalli P, Chan KM. Fast alpha nucleophiles: structures that undergo rapid hydrazone/oxime formation at neutral pH. Organic Letters. 16: 1454-7. PMID 24559274 DOI: 10.1021/ol500262y  1
2013 Harcourt EM, Ehrenschwender T, Batista PJ, Chang HY, Kool ET. Identification of a selective polymerase enables detection of N(6)-methyladenosine in RNA. Journal of the American Chemical Society. 135: 19079-82. PMID 24328136 DOI: 10.1021/ja4105792  1
2013 Winnacker M, Kool ET. Artificial genetic sets composed of size-expanded base pairs. Angewandte Chemie (International Ed. in English). 52: 12498-508. PMID 24249550 DOI: 10.1002/anie.201305267  1
2013 Kool ET, Park DH, Crisalli P. Fast hydrazone reactants: electronic and acid/base effects strongly influence rate at biological pH. Journal of the American Chemical Society. 135: 17663-6. PMID 24224646 DOI: 10.1021/ja407407h  1
2013 Jiang W, Wang S, Yuen LH, Kwon H, Ono T, Kool ET. DNA-polyfluorophore Chemosensors for Environmental Remediation: Vapor-phase Identification of Petroleum Products in Contaminated Soil. Chemical Science (Royal Society of Chemistry : 2010). 4: 3184-3190. PMID 23878719 DOI: 10.1039/C3SC50985K  1
2013 Ono T, Edwards SK, Wang S, Jiang W, Kool ET. Monitoring eukaryotic and bacterial UDG repair activity with DNA-multifluorophore sensors. Nucleic Acids Research. 41: e127. PMID 23644286 DOI: 10.1093/nar/gkt309  1
2013 Singh V, Wang S, Kool ET. Genetically encoded multispectral labeling of proteins with polyfluorophores on a DNA backbone. Journal of the American Chemical Society. 135: 6184-91. PMID 23590213 DOI: 10.1021/ja4004393  1
2013 Crisalli P, Kool ET. Importance of ortho proton donors in catalysis of hydrazone formation. Organic Letters. 15: 1646-9. PMID 23477719 DOI: 10.1021/ol400427x  1
2013 Jung JW, Edwards SK, Kool ET. Selective fluorogenic chemosensors for distinct classes of nucleases. Chembiochem : a European Journal of Chemical Biology. 14: 440-4. PMID 23371801 DOI: 10.1002/cbic.201300001  1
2013 Crisalli P, Kool ET. Water-soluble organocatalysts for hydrazone and oxime formation. The Journal of Organic Chemistry. 78: 1184-9. PMID 23289546 DOI: 10.1021/jo302746p  1
2013 Spitale RC, Crisalli P, Flynn RA, Torre EA, Kool ET, Chang HY. RNA SHAPE analysis in living cells. Nature Chemical Biology. 9: 18-20. PMID 23178934 DOI: 10.1038/nchembio.1131  1
2013 Attwater J, Tagami S, Kimoto M, Butler K, Kool ET, Wengel J, Herdewijn P, Hirao I, Holliger P. Chemical fidelity of an RNA polymerase ribozyme Chemical Science. 4: 2804-2814. DOI: 10.1039/c3sc50574j  1
2012 Crisalli P, Hernández AR, Kool ET. Fluorescence quenchers for hydrazone and oxime orthogonal bioconjugation. Bioconjugate Chemistry. 23: 1969-80. PMID 22913527 DOI: 10.1021/bc300344b  1
2012 Lee SH, Wang S, Kool ET. Templated chemistry for monitoring damage and repair directly in duplex DNA. Chemical Communications (Cambridge, England). 48: 8069-71. PMID 22782065 DOI: 10.1039/c2cc34060g  1
2012 Wang S, Guo J, Ono T, Kool ET. DNA polyfluorophores for real-time multicolor tracking of dynamic biological systems. Angewandte Chemie (International Ed. in English). 51: 7176-80. PMID 22684777 DOI: 10.1002/anie.201201928  1
2012 Hernández AR, Peterson LW, Kool ET. Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases. Acs Chemical Biology. 7: 1454-61. PMID 22646660 DOI: 10.1021/cb300174c  1
2012 Kellinger MW, Ulrich S, Chong J, Kool ET, Wang D. Dissecting chemical interactions governing RNA polymerase II transcriptional fidelity. Journal of the American Chemical Society. 134: 8231-40. PMID 22509745 DOI: 10.1021/ja302077d  1
2012 Teo YN, Kool ET. DNA-multichromophore systems. Chemical Reviews. 112: 4221-45. PMID 22424059 DOI: 10.1021/cr100351g  1
2012 Khakshoor O, Wheeler SE, Houk KN, Kool ET. Measurement and theory of hydrogen bonding contribution to isosteric DNA base pairs. Journal of the American Chemical Society. 134: 3154-63. PMID 22300089 DOI: 10.1021/ja210475a  1
2012 Harcourt EM, Kool ET. Amplified microRNA detection by templated chemistry. Nucleic Acids Research. 40: e65. PMID 22278881 DOI: 10.1093/nar/gkr1313  1
2012 Ono T, Wang S, Koo CK, Engstrom L, David SS, Kool ET. Direct fluorescence monitoring of DNA base excision repair. Angewandte Chemie (International Ed. in English). 51: 1689-92. PMID 22241823 DOI: 10.1002/anie.201108135  1
2012 McKibbin PL, Kobori A, Taniguchi Y, Kool ET, David SS. Surprising repair activities of nonpolar analogs of 8-oxoG expose features of recognition and catalysis by base excision repair glycosylases. Journal of the American Chemical Society. 134: 1653-61. PMID 22175854 DOI: 10.1021/ja208510m  1
2012 Kwon H, Samain F, Kool ET. Fluorescent DNAs printed on paper: Sensing food spoilage and ripening in the vapor phase Chemical Science. 3: 2542-2549. DOI: 10.1039/c2sc20461d  1
2011 Ulrich S, Kool ET. Importance of steric effects on the efficiency and fidelity of transcription by T7 RNA polymerase. Biochemistry. 50: 10343-9. PMID 22044042 DOI: 10.1021/bi2011465  1
2011 Crisalli P, Kool ET. Multi-path quenchers: efficient quenching of common fluorophores. Bioconjugate Chemistry. 22: 2345-54. PMID 22034828 DOI: 10.1021/bc200424r  1
2011 Krueger AT, Peterson LW, Chelliserry J, Kleinbaum DJ, Kool ET. Encoding phenotype in bacteria with an alternative genetic set. Journal of the American Chemical Society. 133: 18447-51. PMID 21981660 DOI: 10.1021/ja208025e  1
2011 Koo CK, Wang S, Gaur RL, Samain F, Banaei N, Kool ET. Fluorescent DNA chemosensors: identification of bacterial species by their volatile metabolites. Chemical Communications (Cambridge, England). 47: 11435-7. PMID 21935547 DOI: 10.1039/c1cc14871k  1
2011 Franzini RM, Kool ET. Improved templated fluorogenic probes enhance the analysis of closely related pathogenic bacteria by microscopy and flow cytometry. Bioconjugate Chemistry. 22: 1869-77. PMID 21870777 DOI: 10.1021/bc2003567  1
2011 Khakshoor O, Kool ET. Chemistry of nucleic acids: impacts in multiple fields. Chemical Communications (Cambridge, England). 47: 7018-24. PMID 21483917 DOI: 10.1039/c1cc11021g  1
2011 Dai N, Guo J, Teo YN, Kool ET. Protease probes built from DNA: multispectral fluorescent DNA-peptide conjugates as caspase chemosensors. Angewandte Chemie (International Ed. in English). 50: 5105-9. PMID 21455915 DOI: 10.1002/anie.201007805  1
2011 Guo J, Wang S, Dai N, Teo YN, Kool ET. Multispectral labeling of antibodies with polyfluorophores on a DNA backbone and application in cellular imaging. Proceedings of the National Academy of Sciences of the United States of America. 108: 3493-8. PMID 21321224 DOI: 10.1073/pnas.1017349108  1
2011 Tan SS, Kim SJ, Kool ET. Differentiating between fluorescence-quenching metal ions with polyfluorophore sensors built on a DNA backbone. Journal of the American Chemical Society. 133: 2664-71. PMID 21294558 DOI: 10.1021/ja109561e  1
2011 Franzini RM, Kool ET. Two successive reactions on a DNA template: a strategy for improving background fluorescence and specificity in nucleic acid detection. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 2168-75. PMID 21294182 DOI: 10.1002/chem.201002426  1
2011 Dai N, Kool ET. Fluorescent DNA-based enzyme sensors. Chemical Society Reviews. 40: 5756-70. PMID 21290032 DOI: 10.1039/c0cs00162g  1
2011 Hernández AR, Kool ET. The components of xRNA: synthesis and fluorescence of a full genetic set of size-expanded ribonucleosides. Organic Letters. 13: 676-9. PMID 21214222 DOI: 10.1021/ol102915f  1
2011 Samain F, Dai N, Kool ET. Differentiating a diverse range of volatile organic compounds with polyfluorophore sensors built on a DNA scaffold. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 174-83. PMID 21207614 DOI: 10.1002/chem.201002836  1
2011 Jarchow-Choy SK, Krueger AT, Liu H, Gao J, Kool ET. Fluorescent xDNA nucleotides as efficient substrates for a template-independent polymerase. Nucleic Acids Research. 39: 1586-94. PMID 20947563 DOI: 10.1093/nar/gkq853  1
2011 Koo CK, Samain F, Dai N, Kool ET. DNA polyfluorophores as highly diverse chemosensors of toxic gases Chemical Science. 2: 1910-1917. DOI: 10.1039/c1sc00301a  1
2010 Kleinbaum DJ, Kool ET. Sandwich probes: two simultaneous reactions for templated nucleic acid detection. Chemical Communications (Cambridge, England). 46: 8154-6. PMID 20927470 DOI: 10.1039/c0cc01968b  1
2010 Tan SS, Teo YN, Kool ET. Selective sensor for silver ions built from polyfluorophores on a DNA backbone. Organic Letters. 12: 4820-3. PMID 20883041 DOI: 10.1021/ol1019794  1
2010 Li H, Franzini RM, Bruner C, Kool ET. Templated chemistry for sequence-specific fluorogenic detection of duplex DNA. Chembiochem : a European Journal of Chemical Biology. 11: 2132-7. PMID 20859985 DOI: 10.1002/cbic.201000329  1
2010 Samain F, Ghosh S, Teo YN, Kool ET. Polyfluorophores on a DNA backbone: sensors of small molecules in the vapor phase. Angewandte Chemie (International Ed. in English). 49: 7025-9. PMID 20721995 DOI: 10.1002/anie.201002701  1
2010 Killelea T, Ghosh S, Tan SS, Heslop P, Firbank SJ, Kool ET, Connolly BA. Probing the interaction of archaeal DNA polymerases with deaminated bases using X-ray crystallography and non-hydrogen bonding isosteric base analogues. Biochemistry. 49: 5772-81. PMID 20527806 DOI: 10.1021/bi100421r  1
2010 Kleinbaum DJ, Miller GP, Kool ET. Double displacement: An improved bioorthogonal reaction strategy for templated nucleic acid detection. Bioconjugate Chemistry. 21: 1115-20. PMID 20509625 DOI: 10.1021/bc100165h  1
2010 Dai N, Teo YN, Kool ET. DNA-polyfluorophore excimers as sensitive reporters for esterases and lipases. Chemical Communications (Cambridge, England). 46: 1221-3. PMID 20449256 DOI: 10.1039/b926338a  1
2010 Lu H, Krueger AT, Gao J, Liu H, Kool ET. Toward a designed genetic system with biochemical function: polymerase synthesis of single and multiple size-expanded DNA base pairs. Organic & Biomolecular Chemistry. 8: 2704-10. PMID 20407680 DOI: 10.1039/c002766a  1
2009 Jarchow-Choy SK, Sjuvarsson E, Sintim HO, Eriksson S, Kool ET. Nonpolar nucleoside mimics as active substrates for human thymidine kinases. Journal of the American Chemical Society. 131: 5488-94. PMID 20560637 DOI: 10.1021/ja808244t  1
2009 Teo YN, Kool ET. Polyfluorophore excimers and exciplexes as FRET donors in DNA. Bioconjugate Chemistry. 20: 2371-80. PMID 19916519 DOI: 10.1021/bc9003926  1
2009 Franzini RM, Kool ET. Efficient nucleic acid detection by templated reductive quencher release. Journal of the American Chemical Society. 131: 16021-3. PMID 19886694 DOI: 10.1021/ja904138v  1
2009 Teo YN, Wilson JN, Kool ET. Polyfluorophore labels on DNA: dramatic sequence dependence of quenching. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 11551-8. PMID 19780115 DOI: 10.1002/chem.200901607  1
2009 Lu H, Lynch SR, Lee AH, Kool ET. Structure and replication of yDNA: a novel genetic set widened by benzo-homologation. Chembiochem : a European Journal of Chemical Biology. 10: 2530-8. PMID 19780073 DOI: 10.1002/cbic.200900434  1
2009 Loakes D, Gallego J, Pinheiro VB, Kool ET, Holliger P. Evolving a polymerase for hydrophobic base analogues. Journal of the American Chemical Society. 131: 14827-37. PMID 19778048 DOI: 10.1021/ja9039696  1
2009 Delaney JC, Gao J, Liu H, Shrivastav N, Essigmann JM, Kool ET. Efficient replication bypass of size-expanded DNA base pairs in bacterial cells. Angewandte Chemie (International Ed. in English). 48: 4524-7. PMID 19444841 DOI: 10.1002/anie.200805683  1
2009 Krueger AT, Kool ET. Redesigning the architecture of the base pair: toward biochemical and biological function of new genetic sets. Chemistry & Biology. 16: 242-8. PMID 19318205 DOI: 10.1016/j.chembiol.2008.12.004  1
2009 Teo YN, Wilson JN, Kool ET. Polyfluorophores on a DNA backbone: a multicolor set of labels excited at one wavelength. Journal of the American Chemical Society. 131: 3923-33. PMID 19254023 DOI: 10.1021/ja805502k  1
2009 Terrazas M, Kool ET. RNA major groove modifications improve siRNA stability and biological activity. Nucleic Acids Research. 37: 346-53. PMID 19042976 DOI: 10.1093/nar/gkn958  1
2009 Sintim HO, Kool ET. Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine (Journal of the American Chemical Society (2006) 128, (396-397)) Journal of the American Chemical Society. 131: 11270. DOI: 10.1021/ja905423u  1
2008 Chelliserrykattil J, Lu H, Lee AH, Kool ET. Polymerase amplification, cloning, and gene expression of benzo-homologous "yDNA" base pairs. Chembiochem : a European Journal of Chemical Biology. 9: 2976-80. PMID 19053129 DOI: 10.1002/cbic.200800339  1
2008 Franzini RM, Kool ET. 7-Azidomethoxy-coumarins as profluorophores for templated nucleic acid detection. Chembiochem : a European Journal of Chemical Biology. 9: 2981-8. PMID 19035374 DOI: 10.1002/cbic.200800507  1
2008 Pomerantz AK, Moerner WE, Kool ET. Visualization of long human telomere mimics by single-molecule fluorescence imaging. The Journal of Physical Chemistry. B. 112: 13184-7. PMID 18817431 DOI: 10.1021/jp806696u  1
2008 Krueger AT, Lu H, Højland T, Liu H, Gao J, Kool ET. Towards the replication of xDNA, a size-expanded unnatural genetic system. Nucleic Acids Symposium Series (2004). 455-6. PMID 18776450 DOI: 10.1093/nass/nrn231  1
2008 Teo YN, Kool ET. Studies of oligodeoxyfluorosides (ODFs) as FRET probes for DNA hybridization. Nucleic Acids Symposium Series (2004). 233-4. PMID 18776339 DOI: 10.1093/nass/nrn118  1
2008 Silverman AP, Abe H, Kool ET. Quenched autoligation probes. Methods in Molecular Biology (Clifton, N.J.). 429: 161-70. PMID 18695965 DOI: 10.1007/978-1-60327-040-3_11  1
2008 Somoza A, Silverman AP, Miller RM, Chelliserrykattil J, Kool ET. Steric effects in RNA interference: probing the influence of nucleobase size and shape. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 7978-87. PMID 18624291 DOI: 10.1002/chem.200800837  1
2008 Franzini RM, Kool ET. Organometallic activation of a fluorogen for templated nucleic acid detection. Organic Letters. 10: 2935-8. PMID 18549220 DOI: 10.1021/ol800878b  1
2008 Silverman AP, Garforth SJ, Prasad VR, Kool ET. Probing the active site steric flexibility of HIV-1 reverse transcriptase: different constraints for DNA- versus RNA-templated synthesis. Biochemistry. 47: 4800-7. PMID 18366188 DOI: 10.1021/bi702427y  1
2008 Krueger AT, Kool ET. Fluorescence of size-expanded DNA bases: reporting on DNA sequence and structure with an unnatural genetic set. Journal of the American Chemical Society. 130: 3989-99. PMID 18311973 DOI: 10.1021/ja0782347  1
2008 Wilson JN, Cho Y, Tan S, Cuppoletti A, Kool ET. Quenching of fluorescent nucleobases by neighboring DNA: the "insulator" concept. Chembiochem : a European Journal of Chemical Biology. 9: 279-85. PMID 18072185 DOI: 10.1002/cbic.200700381  1
2008 Livingston AL, O'Shea VL, Kim T, Kool ET, David SS. Unnatural substrates reveal the importance of 8-oxoguanine for in vivo mismatch repair by MutY. Nature Chemical Biology. 4: 51-8. PMID 18026095 DOI: 10.1038/nchembio.2007.40  1
2008 Lee HR, Helquist SA, Kool ET, Johnson KA. Base pair hydrogen bonds are essential for proofreading selectivity by the human mitochondrial DNA polymerase. The Journal of Biological Chemistry. 283: 14411-6. PMID 17650503 DOI: 10.1074/jbc.M705006200  1
2008 Lee HR, Helquist SA, Kool ET, Johnson KA. Importance of hydrogen bonding for efficiency and specificity of the human mitochondrial DNA polymerase. The Journal of Biological Chemistry. 283: 14402-10. PMID 17650502 DOI: 10.1074/jbc.M705007200  1
2008 Miller GP, Silverman AP, Kool ET. New, stronger nucleophiles for nucleic acid-templated chemistry: Synthesis and application in fluorescence detection of cellular RNA. Bioorganic & Medicinal Chemistry. 16: 56-64. PMID 17502150 DOI: 10.1016/j.bmc.2007.04.051  1
2008 Kool ET. Modified DNA Bases: Probing Base-Pair Recognition by Polymerases Modified Nucleosides: in Biochemistry, Biotechnology and Medicine. 49-74. DOI: 10.1002/9783527623112.ch3  1
2007 Taniguchi Y, Kool ET. Syntheses and properties of low-polarity shape mimics of 8-oxopurines. Nucleic Acids Symposium Series (2004). 217-8. PMID 18029664 DOI: 10.1093/nass/nrm109  1
2007 Wilson JN, Teo YN, Kool ET. Efficient quenching of oligomeric fluorophores on a DNA backbone. Journal of the American Chemical Society. 129: 15426-7. PMID 18027944 DOI: 10.1021/ja075968a  1
2007 Silverman AP, Jiang Q, Goodman MF, Kool ET. Steric and electrostatic effects in DNA synthesis by the SOS-induced DNA polymerases II and IV of Escherichia coli. Biochemistry. 46: 13874-81. PMID 17988102 DOI: 10.1021/bi700851z  1
2007 Krueger AT, Kool ET. Model systems for understanding DNA base pairing. Current Opinion in Chemical Biology. 11: 588-94. PMID 17967435 DOI: 10.1016/j.cbpa.2007.09.019  1
2007 Wilson JN, Gao J, Kool ET. Oligodeoxyfluorosides: Strong Sequence Dependence of Fluorescence Emission. Tetrahedron. 63: 3427-3433. PMID 17940588 DOI: 10.1016/j.tet.2006.07.113  1
2007 Silverman AP, Kool ET. RNA probes of steric effects in active sites: high flexibility of HIV-1 reverse transcriptase. Journal of the American Chemical Society. 129: 10626-7. PMID 17696348 DOI: 10.1021/ja072791b  1
2007 Taniguchi Y, Kool ET. Nonpolar isosteres of damaged DNA bases: effective mimicry of mutagenic properties of 8-oxopurines. Journal of the American Chemical Society. 129: 8836-44. PMID 17592846 DOI: 10.1021/ja071970q  1
2007 Krueger AT, Lu H, Lee AH, Kool ET. Synthesis and properties of size-expanded DNAs: toward designed, functional genetic systems. Accounts of Chemical Research. 40: 141-50. PMID 17309194 DOI: 10.1021/ar068200o  1
2007 Silverman AP, Kool ET. Oligonucleotide probes for RNA-targeted fluorescence in situ hybridization. Advances in Clinical Chemistry. 43: 79-115. PMID 17249381 DOI: 10.1016/S0065-2423(06)43003-1  1
2007 Kool ET, Waters ML. The model student: what chemical model systems can teach us about biology. Nature Chemical Biology. 3: 70-3. PMID 17235337 DOI: 10.1038/nchembio0207-70  1
2007 Garforth SJ, Kim TW, Parniak MA, Kool ET, Prasad VR. Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection. Journal of Molecular Biology. 365: 38-49. PMID 17055529 DOI: 10.1016/j.jmb.2006.09.057  1
2006 Kool ET, Lu H, Kim SJ, Tan S, Wilson JN, Gao J, Liu H. New designs for DNA bases: expanded DNAs and oligofluorosides. Nucleic Acids Symposium Series (2004). 15-6. PMID 17150794 DOI: 10.1093/nass/nrl008  1
2006 Wilson JN, Kool ET. Fluorescent DNA base replacements: Reporters and sensors for biological systems. Organic & Biomolecular Chemistry. 4: 4265-74. PMID 17102869 DOI: 10.1039/b612284c  1
2006 Lynch SR, Liu H, Gao J, Kool ET. Toward a designed, functioning genetic system with expanded-size base pairs: solution structure of the eight-base xDNA double helix. Journal of the American Chemical Society. 128: 14704-11. PMID 17090058 DOI: 10.1021/ja065606n  1
2006 Kool ET, Sintim HO. The difluorotoluene debate--a decade later. Chemical Communications (Cambridge, England). 3665-75. PMID 17047807 DOI: 10.1039/b605414e  1
2006 Silverman AP, Baron EJ, Kool ET. RNA-templated chemistry in cells: discrimination of Escherichia, Shigella and Salmonella bacterial strains with a new two-color FRET strategy. Chembiochem : a European Journal of Chemical Biology. 7: 1890-4. PMID 17031884 DOI: 10.1002/cbic.200600278  1
2006 Yakovleva L, Lai J, Kool ET, Shuman S. Nonpolar nucleobase analogs illuminate requirements for site-specific DNA cleavage by vaccinia topoisomerase. The Journal of Biological Chemistry. 281: 35914-21. PMID 17005552 DOI: 10.1074/jbc.M608349200  1
2006 Silverman AP, Kool ET. Detecting RNA and DNA with templated chemical reactions. Chemical Reviews. 106: 3775-89. PMID 16967920 DOI: 10.1021/cr050057+  1
2006 Lee AH, Kool ET. Exploring the limits of DNA size: naphtho-homologated DNA bases and pairs. Journal of the American Chemical Society. 128: 9219-30. PMID 16834396 DOI: 10.1021/ja0619004  1
2006 Somoza A, Chelliserrykattil J, Kool ET. The roles of hydrogen bonding and sterics in RNA interference. Angewandte Chemie (International Ed. in English). 45: 4994-7. PMID 16802393 DOI: 10.1002/anie.200601311  1
2006 Kim SJ, Kool ET. Sensing metal ions with DNA building blocks: fluorescent pyridobenzimidazole nucleosides. Journal of the American Chemical Society. 128: 6164-71. PMID 16669686 DOI: 10.1021/ja0581806  1
2006 Sintim HO, Kool ET. Remarkable sensitivity to DNA base shape in the DNA polymerase active site. Angewandte Chemie (International Ed. in English). 45: 1974-9. PMID 16506248 DOI: 10.1002/anie.200504296  1
2006 Hariharan C, Bloom LB, Helquist SA, Kool ET, Reha-Krantz LJ. Dynamics of nucleotide incorporation: snapshots revealed by 2-aminopurine fluorescence studies. Biochemistry. 45: 2836-44. PMID 16503638 DOI: 10.1021/bi051644s  1
2006 Mizukami S, Kim TW, Helquist SA, Kool ET. Varying DNA base-pair size in subangstrom increments: evidence for a loose, not large, active site in low-fidelity Dpo4 polymerase. Biochemistry. 45: 2772-8. PMID 16503632 DOI: 10.1021/bi051961z  1
2006 Cho Y, Kool ET. Enzymatic synthesis of fluorescent oligomers assembled on a DNA backbone. Chembiochem : a European Journal of Chemical Biology. 7: 669-72. PMID 16502476 DOI: 10.1002/cbic.200500515  1
2006 Potapova O, Chan C, DeLucia AM, Helquist SA, Kool ET, Grindley ND, Joyce CM. DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics. Biochemistry. 45: 890-8. PMID 16411765 DOI: 10.1021/bi051792i  1
2006 Sintim HO, Kool ET. Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine. Journal of the American Chemical Society. 128: 396-7. PMID 16402811 DOI: 10.1021/ja0562447  1
2006 Abe H, Kool ET. Flow cytometric detection of specific RNAs in native human cells with quenched autoligating FRET probes. Proceedings of the National Academy of Sciences of the United States of America. 103: 263-8. PMID 16384914 DOI: 10.1073/pnas.0509938103  1
2006 Kim TW, Brieba LG, Ellenberger T, Kool ET. Functional evidence for a small and rigid active site in a high fidelity DNA polymerase: probing T7 DNA polymerase with variably sized base pairs. The Journal of Biological Chemistry. 281: 2289-95. PMID 16311403 DOI: 10.1074/jbc.M510744200  1
2005 Abe H, Kool ET. Universal linkers for signal amplification in auto-ligating probes. Nucleic Acids Symposium Series (2004). 37-8. PMID 17150621 DOI: 10.1093/nass/49.1.37  1
2005 Silverman AP, Kool ET. Quenched autoligation probes allow discrimination of live bacterial species by single nucleotide differences in rRNA. Nucleic Acids Research. 33: 4978-86. PMID 16284198 DOI: 10.1093/nar/gki814  1
2005 Hartig JS, Kool ET. Efficient isothermal expansion of human telomeric and minisatellite repeats by Thermococcus litoralis DNA polymerase. Nucleic Acids Research. 33: 4922-7. PMID 16284196 DOI: 10.1093/nar/gki803  1
2005 Kim TW, Delaney JC, Essigmann JM, Kool ET. Probing the active site tightness of DNA polymerase in subangstrom increments. Proceedings of the National Academy of Sciences of the United States of America. 102: 15803-8. PMID 16249340 DOI: 10.1073/pnas.0505113102  1
2005 Wolfle WT, Washington MT, Kool ET, Spratt TE, Helquist SA, Prakash L, Prakash S. Evidence for a Watson-Crick hydrogen bonding requirement in DNA synthesis by human DNA polymerase kappa. Molecular and Cellular Biology. 25: 7137-43. PMID 16055723 DOI: 10.1128/MCB.25.16.7137-7143.2005  1
2005 Hartig JS, Fernandez-Lopez S, Kool ET. Guanine-rich DNA nanocircles for the synthesis and characterization of long cytosine-rich telomeric DNAs. Chembiochem : a European Journal of Chemical Biology. 6: 1458-62. PMID 16052615 DOI: 10.1002/cbic.200500015  1
2005 Devaraj NK, Miller GP, Ebina W, Kakaradov B, Collman JP, Kool ET, Chidsey CE. Chemoselective covalent coupling of oligonucleotide probes to self-assembled monolayers. Journal of the American Chemical Society. 127: 8600-1. PMID 15954758 DOI: 10.1021/ja051462l  0.96
2005 Cuppoletti A, Cho Y, Park JS, Strässler C, Kool ET. Oligomeric fluorescent labels for DNA. Bioconjugate Chemistry. 16: 528-34. PMID 15898718 DOI: 10.1021/bc0497766  1
2005 Silverman AP, Kool ET. Quenched probes for highly specific detection of cellular RNAs. Trends in Biotechnology. 23: 225-30. PMID 15865999 DOI: 10.1016/j.tibtech.2005.03.007  1
2005 Gao J, Liu H, Kool ET. Assembly of the complete eight-base artificial genetic helix, xDNA, and its interaction with the natural genetic system. Angewandte Chemie (International Ed. in English). 44: 3118-22. PMID 15834852 DOI: 10.1002/anie.200500069  1
2005 Kim TW, Kool ET. A series of nonpolar thymidine analogues of increasing size: DNA base pairing and stacking properties. The Journal of Organic Chemistry. 70: 2048-53. PMID 15760186 DOI: 10.1021/jo048061t  1
2005 Lee AH, Kool ET. A new four-base genetic helix, yDNA, composed of widened benzopyrimidine-purine pairs. Journal of the American Chemical Society. 127: 3332-8. PMID 15755149 DOI: 10.1021/ja0430604  1
2005 Lai JS, Kool ET. Fluorous base-pairing effects in a DNA polymerase active site. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 2966-71. PMID 15744767 DOI: 10.1002/chem.200401151  1
2005 Liu H, Gao J, Kool ET. Helix-forming properties of size-expanded DNA, an alternative four-base genetic form. Journal of the American Chemical Society. 127: 1396-402. PMID 15686371 DOI: 10.1021/ja046305l  1
2005 Yoshina-Ishii C, Miller GP, Kraft ML, Kool ET, Boxer SG. General method for modification of liposomes for encoded assembly on supported bilayers. Journal of the American Chemical Society. 127: 1356-7. PMID 15686351 DOI: 10.1021/ja043299k  1
2005 Liu H, Gao J, Kool ET. Size-expanded analogues of dG and dC: synthesis and pairing properties in DNA. The Journal of Organic Chemistry. 70: 639-47. PMID 15651812 DOI: 10.1021/jo048357z  1
2005 Lee AH, Kool ET. Novel benzopyrimidines as widened analogues of DNA bases. The Journal of Organic Chemistry. 70: 132-40. PMID 15624915 DOI: 10.1021/jo0483973  1
2004 Lu H, He K, Kool ET. yDNA: a new geometry for size-expanded base pairs. Angewandte Chemie (International Ed. in English). 43: 5834-6. PMID 15523708 DOI: 10.1002/anie.200461036  1
2004 Hartig JS, Kool ET. Small circular DNAs for synthesis of the human telomere repeat: varied sizes, structures and telomere-encoding activities. Nucleic Acids Research. 32: e152. PMID 15520461 DOI: 10.1093/nar/gnh149  1
2004 Abe H, Kool ET. Destabilizing universal linkers for signal amplification in self-ligating probes for RNA. Journal of the American Chemical Society. 126: 13980-6. PMID 15506759 DOI: 10.1021/ja046791c  1
2004 Kim TW, Kool ET. A set of nonpolar thymidine nucleoside analogues with gradually increasing size. Organic Letters. 6: 3949-52. PMID 15496071 DOI: 10.1021/ol048487u  1
2004 Gao J, Watanabe S, Kool ET. Modified DNA analogues that sense light exposure with color changes. Journal of the American Chemical Society. 126: 12748-9. PMID 15469249 DOI: 10.1021/ja046910o  1
2004 Gao J, Liu H, Kool ET. Expanded-size bases in naturally sized DNA: evaluation of steric effects in Watson-Crick pairing. Journal of the American Chemical Society. 126: 11826-31. PMID 15382917 DOI: 10.1021/ja048499a  1
2004 Liu H, Lynch SR, Kool ET. Solution structure of xDNA: a paired genetic helix with increased diameter. Journal of the American Chemical Society. 126: 6900-5. PMID 15174859 DOI: 10.1021/ja0497835  1
2004 Miller GP, Kool ET. Versatile 5'-functionalization of oligonucleotides on solid support: amines, azides, thiols, and thioethers via phosphorus chemistry. The Journal of Organic Chemistry. 69: 2404-10. PMID 15049637 DOI: 10.1021/jo035765e  1
2004 Niimi A, Limsirichaikul S, Yoshida S, Iwai S, Masutani C, Hanaoka F, Kool ET, Nishiyama Y, Suzuki M. Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity. Molecular and Cellular Biology. 24: 2734-46. PMID 15024063 DOI: 10.1128/MCB.24.7.2734-2746.2004  1
2004 Lai JS, Kool ET. Selective pairing of polyfluorinated DNA bases. Journal of the American Chemical Society. 126: 3040-1. PMID 15012120 DOI: 10.1021/ja039571s  1
2004 Liu H, Gao J, Maynard L, Saito YD, Kool ET. Toward a new genetic system with expanded dimensions: size-expanded analogues of deoxyadenosine and thymidine. Journal of the American Chemical Society. 126: 1102-9. PMID 14746479 DOI: 10.1021/ja038384r  1
2004 Sando S, Abe H, Kool ET. Quenched auto-ligating DNAs: multicolor identification of nucleic acids at single nucleotide resolution. Journal of the American Chemical Society. 126: 1081-7. PMID 14746476 DOI: 10.1021/ja038665z  1
2004 Maki AS, Kim T, Kool ET. Direct comparison of A- and T-strand minor groove interactions in DNA curvature at A tracts. Biochemistry. 43: 1102-10. PMID 14744156 DOI: 10.1021/bi035340m  1
2004 Smietana M, Johnson RB, Wang QM, Kool ET. Solid-phase synthesis and screening of macrocyclic nucleotide-hybrid compounds targeted to hepatitis C NS5B. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 173-81. PMID 14695562 DOI: 10.1002/chem.200305402  1
2003 Kool ET, Miller GP. 5'-Iodination of solid-phase-linked oligodeoxyribonucleotides. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 4.19. PMID 18428909 DOI: 10.1002/0471142700.nc0419s14  1
2003 Francis AW, Helquist SA, Kool ET, David SS. Probing the requirements for recognition and catalysis in Fpg and MutY with nonpolar adenine isosteres. Journal of the American Chemical Society. 125: 16235-42. PMID 14692765 DOI: 10.1021/ja0374426  1
2003 Lai JS, Qu J, Kool ET. Fluorinated DNA bases as probes of electrostatic effects in DNA base stacking. Angewandte Chemie (International Ed. in English). 42: 5973-7. PMID 14679546 DOI: 10.1002/anie.200352531  1
2003 Liu H, Gao J, Lynch SR, Saito YD, Maynard L, Kool ET. A four-base paired genetic helix with expanded size. Science (New York, N.Y.). 302: 868-71. PMID 14593180 DOI: 10.1126/science.1088334  1
2003 Rausch JW, Qu J, Yi-Brunozzi HY, Kool ET, Le Grice SFJ. Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection Proceedings of the National Academy of Sciences of the United States of America. 100: 11279-11284. PMID 12972638 DOI: 10.1073/pnas.1932546100  1
2003 Sun L, Zhang K, Zhou L, Hohler P, Kool ET, Yuan F, Wang Z, Taylor JS. Yeast pol eta holds a cis-syn thymine dimer loosely in the active site during elongation opposite the 3'-T of the dimer, but tightly opposite the 5'-T. Biochemistry. 42: 9431-7. PMID 12899630 DOI: 10.1021/bi0345687  0.4
2003 Washington MT, Helquist SA, Kool ET, Prakash L, Prakash S. Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase eta. Molecular and Cellular Biology. 23: 5107-12. PMID 12832493 DOI: 10.1128/MCB.23.14.5107-5112.2003  1
2003 Delaney JC, Henderson PT, Helquist SA, Morales JC, Essigmann JM, Kool ET. High-fidelity in vivo replication of DNA base shape mimics without Watson-Crick hydrogen bonds. Proceedings of the National Academy of Sciences of the United States of America. 100: 4469-73. PMID 12676985 DOI: 10.1073/pnas.0837277100  1
2003 Maki A, Brownewell FE, Liu D, Kool ET. DNA curvature at A tracts containing a non-polar thymine mimic Nucleic Acids Research. 31: 1059-1066. PMID 12560504 DOI: 10.1093/nar/gkg172  1
2003 Begley TJ, Haas BJ, Morales JC, Kool ET, Cunningham RP. Kinetics and binding of the thymine-DNA mismatch glycosylase, Mig-Mth, with mismatch-containing DNA substrates Dna Repair. 2: 107-120. PMID 12509271 DOI: 10.1016/S1568-7864(02)00190-8  1
2002 Sando S, Kool ET. Nonenzymatic DNA ligation in Escherichia coli cells Nucleic Acids Research. Supplement (2001). 121-122. PMID 12903135  1
2002 Smirnov S, Matray TJ, Kool ET, de los Santos C. Integrity of duplex structures without hydrogen bonding: DNA with pyrene paired at abasic sites Nucleic Acids Research. 30: 5561-5569. PMID 12490724 DOI: 10.1093/nar/gkf688  1
2002 Morales-Rojas H, Kool ET. A Porphyrin C-Nucleoside Incorporated into DNA Organic Letters. 4: 4377-4380. PMID 12465891 DOI: 10.1021/ol0267376  1
2002 Lindstrom UM, Chandrasekaran RA, Orbai L, Helquist SA, Miller GP, Oroudjev E, Hansma HG, Kool ET. Artificial human telomeres from DNA nanocircle templates. Proceedings of the National Academy of Sciences of the United States of America. 99: 15953-8. PMID 12444252 DOI: 10.1073/pnas.252396199  1
2002 Kool ET. Replacing the nucleobases in DNA with designer molecules Accounts of Chemical Research. 35: 936-943. PMID 12437318 DOI: 10.1021/ar000183u  1
2002 Miller GP, Kool ET. A simple method for electrophilic functionalization of DNA. Organic Letters. 4: 3599-601. PMID 12375897  0.96
2002 Smietana M, Kool ET. Efficient and simple solid-phase synthesis of short cyclic oligodeoxynucleotides bearing a phosphorothioate linkage Angewandte Chemie - International Edition. 41: 3704-3707. PMID 12370937 DOI: 10.1002/1521-3773(20021004)41:19<3704::AID-ANIE3704>3.0.CO;2-N  1
2002 Lindström UM, Kool ET. An orthogonal oligonucleotide protecting group strategy that enables assembly of repetitive or highly structured DNAs. Nucleic Acids Research. 30: e101. PMID 12364618  1
2002 Gao J, Strässler C, Tahmassebi D, Kool ET. Libraries of composite polyfluors built from fluorescent deoxyribosides. Journal of the American Chemical Society. 124: 11590-1. PMID 12296712 DOI: 10.1021/ja027197a  1
2002 Drotschmann K, Hall MC, Shcherbakova PV, Wang H, Erie DA, Brownewell FR, Kool ET, Kunkel TA. DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers. Biological Chemistry. 383: 969-75. PMID 12222686 DOI: 10.1515/BC.2002.103  1
2002 O'Neill BM, Ratto JE, Good KL, Tahmassebi DC, Helquist SA, Morales JC, Kool ET. A highly effective nonpolar isostere of deoxyguanosine: synthesis, structure, stacking, and base pairing. The Journal of Organic Chemistry. 67: 5869-75. PMID 12182615 DOI: 10.1021/jo025884e  1
2002 Sando S, Kool ET. Imaging of RNA in bacteria with self-ligating quenched probes Journal of the American Chemical Society. 124: 9686-9687. PMID 12175209 DOI: 10.1021/ja026649g  1
2002 Kool ET. Active site tightness and substrate fit in DNA replication Annual Review of Biochemistry. 71: 191-219. PMID 12045095 DOI: 10.1146/annurev.biochem.71.110601.135453  1
2002 Sando S, Kool ET. Quencher as leaving group: Efficient detection of DNA-joining reactions Journal of the American Chemical Society. 124: 2096-2097. PMID 11878946 DOI: 10.1021/ja017328s  1
2002 Ohmich T, Maki A, Kool ET. Efficient bacterial transcription of DNA nanocircle vectors with optimized single-stranded promoters Proceedings of the National Academy of Sciences of the United States of America. 99: 54-59. PMID 11752404 DOI: 10.1073/pnas.012589099  1
2002 Miller GP, Kool ET. A simple method for electrophilic functionalization of DNA Organic Letters. 4: 3599-3601. DOI: 10.1021/ol0264915  1
2001 Diegelman AM, Kool ET. Chemical and enzymatic methods for preparing circular single-stranded DNAs. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 5.2. PMID 18428858 DOI: 10.1002/0471142700.nc0502s00  1
2001 Drotschmann K, Yang W, Brownewell FE, Kool ET, Kunkel TA. Asymmetric recognition of DNA local distortion: Structure-based functional studies of eukaryotic Msh2-Msh6 Journal of Biological Chemistry. 276: 46225-46229. PMID 11641390 DOI: 10.1074/jbc.C100450200  1
2001 Kool ET. Hydrogen bonding, base stacking, and steric effects in DNA replication Annual Review of Biophysics and Biomolecular Structure. 30: 1-22. PMID 11340050 DOI: 10.1146/annurev.biophys.30.1.1  1
2001 Dzantiev L, Alekseyev YO, Morales JC, Kool ET, Romano LJ. Significance of nucleobase shape complementarity and hydrogen bonding in the formation and stability of the closed polymerase - DNA complex Biochemistry. 40: 3215-3221. PMID 11258938 DOI: 10.1021/bi002569i  1
2001 Xu Y, Karalkar NB, Kool ET. Nonenzymatic autoligation in direct three-color detection of RNA and DNA point mutations Nature Biotechnology. 19: 148-152. PMID 11175729 DOI: 10.1038/84414  1
2001 Schofield MJ, Brownewell FE, Nayak S, Du C, Kool ET, Hsieh P. The Phe-X-Glu DNA binding motif of MutS: The role of hydrogen bonding in mismatch recognition Journal of Biological Chemistry. 276: 45505-45508. DOI: 10.1074/jbc.C100449200  1
2000 Guckian KM, Krugh TR, Kool ET. Solution Structure of a Nonpolar, Non-Hydrogen-Bonded Base Pair Surrogate in DNA. Journal of the American Chemical Society. 122: 6841-6847. PMID 20882115 DOI: 10.1021/ja994164v  1
2000 Morales JC, Kool ET. Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes. Journal of the American Chemical Society. 122: 1001-1007. PMID 20882113 DOI: 10.1021/ja993464+  0.52
2000 Guckian KM, Schweitzer BA, Ren RX, Sheils CJ, Tahmassebi DC, Kool ET. Factors Contributing to Aromatic Stacking in Water: Evaluation in the Context of DNA. Journal of the American Chemical Society. 122: 2213-2222. PMID 20865137 DOI: 10.1021/ja9934854  1
2000 Kool ET. Roles of Watson-Crick and minor groove hydrogen bonds in DNA replication Cold Spring Harbor Symposia On Quantitative Biology. 65: 93-102. PMID 12760024  1
2000 Kool ET. Synthetically modified DNAs as substrates for polymerases Current Opinion in Chemical Biology. 4: 602-608. PMID 11102863 DOI: 10.1016/S1367-5931(00)00141-1  1
2000 Sun L, Wang M, Kool ET, Taylor JS. Pyrene nucleotide as a mechanistic probe: evidence for a transient abasic site-like intermediate in the bypass of dipyrimidine photoproducts by T7 DNA polymerase. Biochemistry. 39: 14603-10. PMID 11087416  0.4
2000 Morales JC, Kool ET. Functional hydrogen-bonding map of the minor groove binding tracks of six DNA polymerases Biochemistry. 39: 12979-12988. PMID 11041863 DOI: 10.1021/bi001578o  1
2000 Kool ET, Morales JC, Guckian KM. Mimicking the Structure and Function of DNA: Insights into DNA Stability and Replication. Angewandte Chemie (International Ed. in English). 39: 990-1009. PMID 10760910 DOI: 10.1002/(SICI)1521-3773(20000317)39:6<990::AID-ANIE990>3.0.CO;2-0  1
2000 Morales JC, Kool ET. Importance of terminal base pair hydrogen-bonding in 3'-end proofreading by the Klenow fragment of DNA polymerase I Biochemistry. 39: 2626-2632. PMID 10704212 DOI: 10.1021/bi992173a  1
2000 Ohmichi T, Kool ET. The virtues of self-binding: High sequence specificity for RNA cleavage by self-processed hammerhead ribozymes Nucleic Acids Research. 28: 776-783. PMID 10637330  1
2000 Xu Y, Kool ET. Rapid and selective selenium-mediated autoligation of DNA strands [8] Journal of the American Chemical Society. 122: 9040-9041. DOI: 10.1021/ja994019h  1
2000 Morales JC, Kool ET. Varied molecular interactions at the active sites of several DNA polymerases: Nonpolar nucleoside isosteres as probes Journal of the American Chemical Society. 122: 1001-1007. DOI: 10.1021/ja993464+  1
1999 Strässler C, Davis NE, Kool ET. Novel Nucleoside Analogues with Fluorophores Replacing the DNA Base. Helvetica Chimica Acta. 82: 2160-2171. PMID 20016809 DOI: 10.1002/(SICI)1522-2675(19991215)82:12<2160::AID-HLCA2160>3.0.CO;2-4  1
1999 Rowley PT, Kosciolek BA, Kool ET. Circular antisense oligonucleotides inhibit growth of chronic myeloid leukemia cells. Molecular Medicine (Cambridge, Mass.). 5: 693-700. PMID 10602778  1
1999 Hansma HG, Golan R, Hsieh W, Daubendiek SL, Kool ET. Polymerase activities and RNA structures in the atomic force microscope Journal of Structural Biology. 127: 240-247. PMID 10544049 DOI: 10.1006/jsbi.1999.4170  1
1999 Barsky D, Kool ET, Colvin ME. Interaction and solvation energies of nonpolar DNA base analogues and their role in polymerase insertion fidelity Journal of Biomolecular Structure and Dynamics. 16: 1119-1134. PMID 10447197  1
1999 Diegelman AM, Kool ET. Mimicry of the hepatitis delta virus replication cycle mediated by synthetic circular oligodeoxynucleotides. Chemistry & Biology. 6: 569-76. PMID 10421762 DOI: 10.1016/S1074-5521(99)80089-1  1
1999 Matray TJ, Kool ET. A specific partner for abasic damage in DNA Nature. 399: 704-708. PMID 10385125 DOI: 10.1038/21453  1
1999 Thomson NH, Smith BL, Almqvist N, Schmitt L, Kashlev M, Kool ET, Hansma PK. Oriented, active Escherichia coli RNA polymerase: An atomic force microscope study Biophysical Journal. 76: 1024-1033. PMID 9916034  1
1999 Frieden M, Pedroso E, Kool ET. Tightening the belt on polymerases: Evaluating the physical constraints on enzyme substrate size Angewandte Chemie - International Edition. 38: 3654-3657. DOI: 10.1002/(SICI)1521-3773(19991216)38:24<3654::AID-ANIE3654>3.0.CO;2-S  1
1998 Guckian KM, Morales JC, Kool ET. Structure and Base Pairing Properties of a Replicable Nonpolar Isostere for Deoxyadenosine. The Journal of Organic Chemistry. 63: 9652-9656. PMID 20852720 DOI: 10.1021/jo9805100  1
1998 Diegelman AM, Daubendiek SL, Kool ET. Generation of RNA ladders by rolling circle transcription of small circular oligodeoxyribonucleotides. Biotechniques. 25: 754-8. PMID 9821573  1
1998 Guckian KM, Krugh TR, Kool ET. Solution structure of a DNA duplex containing a replicable difluorotoluene-adenine pair. Nature Structural Biology. 5: 954-9. PMID 9808039 DOI: 10.1038/2930  1
1998 Diegelman AM, Kool ET. Generation of circular RNAs and trans-cleaving catalytic RNAs by rolling transcription of circular DNA oligonucleotides encoding hairpin ribozymes. Nucleic Acids Research. 26: 3235-41. PMID 9628924 DOI: 10.1093/nar/26.13.3235  1
1998 Ryan K, Kool ET. Triplex-directed self-assembly of an artificial sliding clamp on duplex DNA. Chemistry & Biology. 5: 59-67. PMID 9495829  1
1997 Guckian KM, Kool ET. Highly Precise Shape Mimicry by a Difluorotoluene Deoxynucleoside, a Replication-Competent Substitute for Thymidine. Angewandte Chemie (International Ed. in English). 36: 2825-2828. PMID 20882112 DOI: 10.1002/anie.199728251  0.88
1996 Guckian KM, Schweitzer BA, Ren RX, Sheils CJ, Paris PL, Tahmassebi DC, Kool ET. Experimental Measurement of Aromatic Stacking Affinities in the Context of Duplex DNA. Journal of the American Chemical Society. 118: 8182-8183. PMID 20882117 DOI: 10.1021/ja961733f  1
1996 Ren XF, Schweitzer BA, Sheils CJ, Kool ET. Formation of Stable DNA Loops by Incorporation of Nonpolar, Non-Hydrogen-Bonding Nucleoside Isosteres. Angewandte Chemie (International Ed. in English). 35: 743-746. PMID 20882114 DOI: 10.1002/anie.199607431  1
1996 Liu D, Daubendiek SL, Zillman MA, Ryan K, Kool ET. Rolling Circle DNA Synthesis: Small Circular Oligonucleotides as Efficient Templates for DNA Polymerases. Journal of the American Chemical Society. 118: 1587-1594. PMID 20830216 DOI: 10.1021/ja952786k  1
1995 Daubendiek SL, Ryan K, Kool ET. Rolling-Circle RNA Synthesis: Circular Oligonucleotides as Efficient Substrates for T7 RNA Polymerase. Journal of the American Chemical Society. 117: 7818-7819. PMID 27524830 DOI: 10.1021/ja00134a032  1
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