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Jeffery W. Kelly, Ph.D. - Publications

Affiliations: 
Chemistry and Molecular Medicine Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Chemical Biology, protein folding
Website:
http://www.scripps.edu/skaggs/kelly/dr_kelly.php?a=l&cid=1
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370 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Dasari AKR, Arreola J, Michael B, Griffin RG, Kelly JW, Lim KH. Disruption of the CD loop by Enzymatic Cleavage Promotes the Formation of Toxic Transthyretin Oligomers through a Common Transthyretin Misfolding Pathway. Biochemistry. PMID 32500705 DOI: 10.1021/acs.biochem.0c00079  0.4
2020 Dasari AKR, Hung I, Michael B, Gan Z, Kelly JW, Connors LH, Griffin RG, Lim KH. Structural Characterization of Cardiac ex vivo Transthyretin Amyloid: Insight into Transthyretin Misfolding Pathway in vivo. Biochemistry. PMID 32338497 DOI: 10.1021/acs.biochem.0c00091  0.4
2020 Dukovski D, Villella A, Bastos C, King R, Finley D, Kelly JW, Morimoto RI, Hartl FU, Munoz B, Lee PS, Zecevic M, Miller JP. Amplifiers co-translationally enhance CFTR biosynthesis via PCBP1-mediated regulation of CFTR mRNA. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 32067958 DOI: 10.1016/j.jcf.2020.02.006  0.4
2019 Rennella E, Morgan GJ, Yan N, Kelly JW, Kay LE. The role of protein thermodynamics and primary structure in fibrillogenesis of variable domains from immunoglobulin light-chains. Journal of the American Chemical Society. PMID 31364359 DOI: 10.1021/jacs.9b05499  0.76
2019 Monteiro C, Mesgazardeh JS, Anselmo J, Fernandes J, Novais M, Rodrigues C, Brighty GJ, Powers DL, Powers ET, Coelho T, Kelly JW. Predictive model of response to tafamidis in hereditary ATTR polyneuropathy. Jci Insight. 4. PMID 31217346 DOI: 10.1172/jci.insight.126526  1
2019 Ruberg FL, Grogan M, Hanna M, Kelly JW, Maurer MS. Transthyretin Amyloid Cardiomyopathy: JACC State-of-the-Art Review. Journal of the American College of Cardiology. 73: 2872-2891. PMID 31171094 DOI: 10.1016/j.jacc.2019.04.003  0.32
2019 Plate L, Rius B, Nguyen B, Genereux JC, Kelly JW, Wiseman RL. Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein. Cell Chemical Biology. PMID 31105062 DOI: 10.1016/j.chembiol.2019.04.001  1
2019 Morgan GJ, Yan NL, Mortenson DE, Rennella E, Blundon JM, Gwin RM, Lin CY, Stanfield RL, Brown SJ, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay LE, Wilson IA, ... Kelly JW, et al. Stabilization of amyloidogenic immunoglobulin light chains by small molecules. Proceedings of the National Academy of Sciences of the United States of America. PMID 30971495 DOI: 10.1073/pnas.1817567116  0.76
2019 Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nature Communications. 10: 187. PMID 30643122 DOI: 10.1038/s41467-018-08129-2  1
2019 Sun X, Jaeger M, Kelly JW, Dyson HJ, Wright PE. Correction to "Mispacking of the Phe87 Side Chain Reduces the Kinetic Stability of Human Transthyretin". Biochemistry. PMID 30614696 DOI: 10.1021/acs.biochem.8b01312  0.64
2018 Rennella E, Morgan GJ, Kelly JW, Kay LE. Role of domain interactions in the aggregation of full-length immunoglobulin light chains. Proceedings of the National Academy of Sciences of the United States of America. PMID 30598439 DOI: 10.1073/pnas.1817538116  0.76
2018 Sun X, Jaeger M, Kelly JW, Dyson J, Wright PE. Mispacking of the Phe87 side chain reduces the kinetic stability of human transthyretin. Biochemistry. PMID 30540442 DOI: 10.1021/acs.biochem.8b01046  0.52
2018 Lampkin BJ, Monteiro C, Powers ET, Bouc PM, Kelly JW, VanVeller B. A designed protein binding-pocket to control excited-state intramolecular proton transfer fluorescence. Organic & Biomolecular Chemistry. PMID 30534794 DOI: 10.1039/c8ob02673d  1
2018 Sperry BW, Reyes BA, Ikram A, Donnelly JP, Phelan D, Jaber WA, Shapiro D, Evans PJ, Maschke S, Kilpatrick SE, Tan CD, Rodriguez ER, Monteiro C, Tang WHW, Kelly JW, et al. Tenosynovial and Cardiac Amyloidosis in Patients Undergoing Carpal Tunnel Release. Journal of the American College of Cardiology. 72: 2040-2050. PMID 30336828 DOI: 10.1016/j.jacc.2018.07.092  0.6
2018 Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW. Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins. Elife. 7. PMID 30084354 DOI: 10.7554/eLife.37168  1
2018 Madhivanan K, Greiner ER, Alves-Ferreira M, Soriano-Castell D, Rouzbeh N, Aguirre CA, Paulsson JF, Chapman J, Jiang X, Ooi FK, Lemos C, Dillin A, Prahlad V, Kelly JW, Encalada SE. Cellular clearance of circulating transthyretin decreases cell-nonautonomous proteotoxicity in . Proceedings of the National Academy of Sciences of the United States of America. PMID 30061394 DOI: 10.1073/pnas.1801117115  0.88
2018 Monteiro C, Martins da Silva A, Ferreira N, Mesgarzadeh J, Novais M, Coelho T, Kelly JW. Cerebrospinal fluid and vitreous body exposure to orally administered tafamidis in hereditary ATTRV30M (p.TTRV50M) amyloidosis patients. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-9. PMID 29993288 DOI: 10.1080/13506129.2018.1479249  0.6
2018 Leach BI, Zhang X, Kelly JW, Dyson J, Wright PE. NMR measurements reveal the structural basis of transthyretin destabilization by pathogenic mutations. Biochemistry. PMID 29972637 DOI: 10.1021/acs.biochem.8b00642  1
2018 Bamberger C, Martínez-Bartolomé S, Montgomery M, Pankow S, Hulleman JD, Kelly JW, Yates JR. Deducing the presence of proteins and proteoforms in quantitative proteomics. Nature Communications. 9: 2320. PMID 29899466 DOI: 10.1038/s41467-018-04411-5  1
2018 Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Science Signaling. 11. PMID 29440509 DOI: 10.1126/scisignal.aan5785  1
2017 Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW. "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. Journal of the American Chemical Society. PMID 29265822 DOI: 10.1021/jacs.7b08366  1
2017 Martins da Silva A, Cavaco S, Fernandes J, Samões R, Alves C, Cardoso M, Kelly JW, Monteiro C, Coelho T. Age-dependent cognitive dysfunction in untreated hereditary transthyretin amyloidosis. Journal of Neurology. PMID 29209781 DOI: 10.1007/s00415-017-8668-8  0.6
2017 Morgan GJ, Usher GA, Kelly JW. Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients? Biochemistry. PMID 29200282 DOI: 10.1021/acs.biochem.7b00579  0.76
2017 Savas JN, Wang YZ, DeNardo LA, Martinez-Bartolome S, McClatchy DB, Hark TJ, Shanks NF, Cozzolino KA, Lavallée-Adam M, Smukowski SN, Park SK, Kelly JW, Koo EH, Nakagawa T, Masliah E, et al. Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology. Cell Reports. 21: 2614-2627. PMID 29186695 DOI: 10.1016/j.celrep.2017.11.009  0.68
2017 Morgan GJ, Burkhardt DH, Kelly JW, Powers ET. Translation efficiency is maintained at elevated temperature in E. coli. The Journal of Biological Chemistry. PMID 29183994 DOI: 10.1074/jbc.RA117.000284  1
2017 Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, ... ... Kelly JW, et al. Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients. Science Translational Medicine. 9. PMID 28904227 DOI: 10.1126/scitranslmed.aam7621  1
2017 Lim KH, Dasari AKR, Ma R, Hung I, Gan Z, Kelly JW, Fitzgerald MC. Pathogenic Mutations Induce Partial Structural Changes in Native β-Sheet Structure of Transthyretin and Accelerate Aggregation. Biochemistry. PMID 28820582 DOI: 10.1021/acs.biochem.7b00658  0.4
2017 Huang YW, Yang HI, Wu YT, Hsu TL, Lin TW, Kelly JW, Wong CH. Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-glycosylation Efficiency. Journal of the American Chemical Society. PMID 28820257 DOI: 10.1021/jacs.7b03868  0.72
2017 Ardejani MS, Powers ET, Kelly JW. Using Cooperatively Folded Peptides To Measure Interaction Energies and Conformational Propensities. Accounts of Chemical Research. PMID 28723063 DOI: 10.1021/acs.accounts.7b00195  1
2017 Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL. The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer. The Embo Journal. PMID 28655754 DOI: 10.15252/embj.201695616  1
2017 Connelly S, Mortenson DE, Choi S, Wilson IA, Powers ET, Kelly JW, Johnson SM. Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28625364 DOI: 10.1016/j.bmcl.2017.05.080  1
2017 Fernandes L, Moraes N, Sagrillo FS, Magalhães AV, de Moraes MC, Romão L, Kelly JW, Foguel D, Grimster NP, Palhano FL. An ortho-Iminoquinone Compound Reacts with Lysine Inhibiting Aggregation while Remodeling Mature Amyloid Fibrils. Acs Chemical Neuroscience. PMID 28425704 DOI: 10.1021/acschemneuro.7b00017  0.88
2017 Alvarez-Garcia O, Matsuzaki T, Olmer M, Plate L, Kelly JW, Lotz MK. REDD1 deficiency impairs autophagy and mitochondrial biogenesis in articular cartilage and increases the severity of experimental osteoarthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28334504 DOI: 10.1002/art.40104  0.92
2016 Chen JJ, Genereux JC, Suh EH, Vartabedian VF, Rius B, Qu S, Dendle MT, Kelly JW, Wiseman RL. Endoplasmic Reticulum Proteostasis Influences the Oligomeric State of an Amyloidogenic Protein Secreted from Mammalian Cells. Cell Chemical Biology. PMID 27720586 DOI: 10.1016/j.chembiol.2016.09.001  1
2016 Lim KH, Dasari AK, Hung IF, Gan Z, Kelly JW, Wright PE, Wemmer DE. Solid-State NMR Studies Reveal Native-like β-sheet Structures in Transthyretin amyloid. Biochemistry. PMID 27589034 DOI: 10.1021/acs.biochem.6b00649  0.52
2016 Kurian SM, Novais M, Whisenant T, Gelbart T, Buxbaum JN, Kelly JW, Coelho T, Salomon DR. Peripheral Blood Cell Gene Expression Diagnostic for Identifying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures. Theranostics. 6: 1792-809. PMID 27570551 DOI: 10.7150/thno.14584  0.8
2016 Morgan GJ, Kelly JW. The kinetic stability of a full-length antibody light chain dimer determines whether endoproteolysis can release amyloidogenic variable domains. Journal of Molecular Biology. PMID 27569045 DOI: 10.1016/j.jmb.2016.08.021  0.76
2016 Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, ... ... Kelly JW, et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife. 5. PMID 27435961 DOI: 10.7554/eLife.15550  1
2016 Plate L, Paxman RJ, Wiseman RL, Kelly JW. Modulating protein quality control. Elife. 5. PMID 27435959 DOI: 10.7554/eLife.18431  1
2016 Hsu CH, Park S, Mortenson DE, Foley BL, Wang X, Woods RJ, Case DA, Powers ET, Wong CH, Dyson HJ, Kelly JW. The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate. Journal of the American Chemical Society. PMID 27249581 DOI: 10.1021/jacs.6b02879  1
2016 Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, ... Kelly JW, et al. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding-site Tyr Residue. Journal of the American Chemical Society. PMID 27191344 DOI: 10.1021/jacs.6b02960  1
2016 Ankarcrona M, Winblad B, Monteiro C, Fearns C, Powers ET, Johansson J, Westermark GT, Presto J, Ericzon BG, Kelly JW. Current and future treatment of amyloid diseases. Journal of Internal Medicine. PMID 27165517 DOI: 10.1111/joim.12506  1
2016 Chen W, Kong L, Connelly S, Dendle JM, Liu Y, Wilson IA, Powers ET, Kelly JW. Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon. Acs Chemical Biology. PMID 27128252 DOI: 10.1021/acschembio.5b01035  1
2016 Lim KH, Dasari AK, Hung I, Gan Z, Kelly JW, Wemmer DE. Structural Changes Associated with Transthyretin Misfolding and Amyloid Formation Revealed by Solution and Solid-State NMR. Biochemistry. PMID 26998642 DOI: 10.1021/acs.biochem.6b00164  0.48
2016 Coelho T, Merlini G, Bulawa CE, Fleming JA, Judge DP, Kelly JW, Maurer MS, Planté-Bordeneuve V, Labaudinière R, Mundayat R, Riley S, Lombardo I, Huertas P. Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis. Neurology and Therapy. PMID 26894299 DOI: 10.1007/s40120-016-0040-x  0.44
2016 Dave K, Jäger M, Nguyen H, Kelly JW, Gruebele M. High-resolution mapping of the folding transition state of a WW domain. Journal of Molecular Biology. PMID 26880334 DOI: 10.1016/j.jmb.2016.02.008  0.64
2016 Baranczak A, Kelly JW. A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases. Current Opinion in Chemical Biology. 32: 10-21. PMID 26859714 DOI: 10.1016/j.cbpa.2016.01.009  1
2016 Xie C, Pan Y, McLean C, Mar V, Wolfe R, Kelly JW. Scalp melanoma: Distinctive high risk clinical and histological features. The Australasian Journal of Dermatology. PMID 26768190 DOI: 10.1111/ajd.12437  0.64
2015 Chen W, Dong J, Li S, Liu Y, Wang Y, Yoon L, Wu P, Sharpless KB, Kelly JW. Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy. Angewandte Chemie (International Ed. in English). PMID 26696445 DOI: 10.1002/anie.201509016  1
2015 Bolshinsky V, Lin MJ, Serpell J, Leung M, Wolfe R, McLean C, Kelly JW. Frequency of residual melanoma in wide local excision (WLE) specimens after complete excisional biopsy. Journal of the American Academy of Dermatology. PMID 26601566 DOI: 10.1016/j.jaad.2015.08.065  0.64
2015 Cicchiello M, Lin MJ, Pan Y, McLean C, Kelly JW. An assessment of clinical pathways and missed opportunities for the diagnosis of nodular melanoma versus superficial spreading melanoma. The Australasian Journal of Dermatology. PMID 26563931 DOI: 10.1111/ajd.12416  0.64
2015 Meani RE, Pan Y, McLean C, Haydon A, Leung M, Kelly JW. The Victorian Melanoma Service: A 20-year review of an Australian multidisciplinary cancer service. The Australasian Journal of Dermatology. PMID 26559638 DOI: 10.1111/ajd.12413  0.64
2015 Eisele YS, Monteiro C, Fearns C, Encalada SE, Wiseman RL, Powers ET, Kelly JW. Targeting protein aggregation for the treatment of degenerative diseases. Nature Reviews. Drug Discovery. PMID 26338154 DOI: 10.1038/nrd4593  1
2015 Luen S, Wong SW, Mar V, Kelly JW, McLean C, McArthur GA, Haydon A. Primary Tumor Thickness is a Prognostic Factor in Stage IV Melanoma: A Retrospective Study of Primary Tumor Characteristics. American Journal of Clinical Oncology. PMID 26325493 DOI: 10.1097/COC.0000000000000226  0.64
2015 Liu Y, Zhang X, Chen W, Tan YL, Kelly JW. Fluorescence Turn-On Folding Sensor To Monitor Proteome Stress in Live Cells. Journal of the American Chemical Society. PMID 26305239 DOI: 10.1021/jacs.5b04366  1
2015 Cho Y, Baranczak A, Helmke S, Teruya S, Horn EM, Maurer MS, Kelly JW. Personalized medicine approach for optimizing the dose of tafamidis to potentially ameliorate wild-type transthyretin amyloidosis (cardiomyopathy). Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 22: 175-80. PMID 26193961 DOI: 10.3109/13506129.2015.1063485  0.6
2015 Murray AN, Chen W, Antonopoulos A, Hanson SR, Wiseman RL, Dell A, Haslam SM, Powers DL, Powers ET, Kelly JW. Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity. Chemistry & Biology. 22: 1052-62. PMID 26190824 DOI: 10.1016/j.chembiol.2015.06.017  1
2015 Kelly JW, Hammel W, Sjolund LA, Siegel ZD. Frontal extents in virtual environments are not immune to underperception. Attention, Perception & Psychophysics. PMID 26105656 DOI: 10.3758/s13414-015-0948-8  0.8
2015 Chen X, He Q, Kelly JW, Fiete IR, McNamara TP. Bias in Human Path Integration Is Predicted by Properties of Grid Cells. Current Biology : Cb. 25: 1771-6. PMID 26073138 DOI: 10.1016/j.cub.2015.05.031  0.8
2015 Baranczak A, Liu Y, Connelly S, Du WG, Greiner ER, Genereux JC, Wiseman RL, Eisele YS, Bradbury NC, Dong J, Noodleman L, Sharpless KB, Wilson IA, Encalada SE, Kelly JW. A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans. Journal of the American Chemical Society. 137: 7404-14. PMID 26051248 DOI: 10.1021/jacs.5b03042  1
2015 Cho Y, Zhang X, Pobre KF, Liu Y, Powers DL, Kelly JW, Gierasch LM, Powers ET. Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli. Cell Reports. 11: 321-33. PMID 25843722 DOI: 10.1016/j.celrep.2015.03.018  1
2015 Mar VJ, Liu W, Devitt B, Wong SQ, Dobrovic A, McArthur GA, Wolfe R, Kelly JW. The role of BRAF mutations in primary melanoma growth rate and survival. The British Journal of Dermatology. PMID 25752325 DOI: 10.1111/bjd.13756  0.64
2015 Lin MJ, Mar V, McLean C, Wolfe R, Kelly JW. Letter to the editor. The Australasian Journal of Dermatology. 56: 66. PMID 25688701 DOI: 10.1111/ajd.12234  0.64
2015 Pan Y, Haydon AM, McLean CA, McDonald PB, Kelly JW. Prognosis associated with cutaneous melanoma metastases. The Australasian Journal of Dermatology. 56: 25-8. PMID 25688698 DOI: 10.1111/ajd.12293  0.64
2015 Kelly JW, Carpenter SK, Sjolund LA. Retrieval Enhances Route Knowledge Acquisition, but Only When Movement Errors are Prevented. Journal of Experimental Psychology. Learning, Memory, and Cognition. PMID 25581223 DOI: 10.1037/a0038685  0.8
2015 Hulleman JD, Kelly JW. Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 565-75. PMID 25389134 DOI: 10.1096/fj.14-255414  1
2015 Genereux JC, Qu S, Zhou M, Ryno LM, Wang S, Shoulders MD, Kaufman RJ, Lasmézas CI, Kelly JW, Wiseman RL. Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. The Embo Journal. 34: 4-19. PMID 25361606 DOI: 10.15252/embj.201488896  1
2015 Cho Y, Baranczak A, Helmke S, Teruya S, Horn EM, Maurer MS, Kelly JW. Personalized medicine approach for optimizing the dose of tafamidis to potentially ameliorate wild-type transthyretin amyloidosis (cardiomyopathy) Amyloid. 22: 175-180. DOI: 10.3109/13506129.2015.1063485  1
2015 Pantelides SN, Kelly JW, Avraamides MN. Integration of spatial information across vision and language Journal of Cognitive Psychology. DOI: 10.1080/20445911.2015.1102144  0.8
2015 Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto SI, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, ... ... Kelly JW, et al. Correction to supporting information for "Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss," Proceedings of the National Academy of Sciences of the United States of America. 112: E3751-E3752. DOI: 10.1073/pnas.1511282112  1
2015 Murray AN, Chen W, Antonopoulos A, Hanson SR, Wiseman RL, Dell A, Haslam SM, Powers DL, Powers ET, Kelly JW. Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity Chemistry and Biology. DOI: 10.1016/j.chembiol.2015.06.017  1
2014 Lyons G, Chamberlain AJ, Kelly JW. Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. The Australasian Journal of Dermatology. PMID 25495637 DOI: 10.1111/ajd.12206  0.64
2014 Hebert DN, Lamriben L, Powers ET, Kelly JW. The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis. Nature Chemical Biology. 10: 902-10. PMID 25325701 DOI: 10.1038/nchembio.1651  1
2014 Liu Y, Zhang X, Tan YL, Bhabha G, Ekiert DC, Kipnis Y, Bjelic S, Baker D, Kelly JW. De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters. Journal of the American Chemical Society. 136: 13102-5. PMID 25209927 DOI: 10.1021/ja5056356  1
2014 Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL. Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain. Proceedings of the National Academy of Sciences of the United States of America. 111: 13046-51. PMID 25157167 DOI: 10.1073/pnas.1406050111  1
2014 Greiner ER, Kelly JW, Palhano FL. Immunoprecipitation of amyloid fibrils by the use of an antibody that recognizes a generic epitope common to amyloid fibrils. Plos One. 9: e105433. PMID 25144803 DOI: 10.1371/journal.pone.0105433  1
2014 Shen S, Wolfe R, McLean CA, Haskett M, Kelly JW. Characteristics and associations of high-mitotic-rate melanoma. Jama Dermatology. 150: 1048-55. PMID 25142970 DOI: 10.1001/jamadermatol.2014.635  0.64
2014 Tan YL, Genereux JC, Pankow S, Aerts JM, Yates JR, Kelly JW. ERdj3 is an endoplasmic reticulum degradation factor for mutant glucocerebrosidase variants linked to Gaucher's disease. Chemistry & Biology. 21: 967-76. PMID 25126989 DOI: 10.1016/j.chembiol.2014.06.008  1
2014 Meani RE, Lim SW, Chang AL, Kelly JW. Emergence of chemoresistance in a metastatic basal cell carcinoma patient after complete response to hedgehog pathway inhibitor vismodegib (GDC-0449). The Australasian Journal of Dermatology. 55: 218-21. PMID 25117162 DOI: 10.1111/ajd.12196  0.64
2014 Zhang X, Liu Y, Genereux JC, Nolan C, Singh M, Kelly JW. Heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli. Acs Chemical Biology. 9: 1945-9. PMID 25051296 DOI: 10.1021/cb5004477  1
2014 Mar VJ, Wong SQ, Logan A, Nguyen T, Cebon J, Kelly JW, Wolfe R, Dobrovic A, McLean C, McArthur GA. Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma. Pigment Cell & Melanoma Research. 27: 1117-25. PMID 25043693 DOI: 10.1111/pcmr.12295  0.64
2014 Lin MJ, Mar V, McLean C, Kelly JW. An objective measure of growth rate using partial biopsy specimens of melanomas that were initially misdiagnosed. Journal of the American Academy of Dermatology. 71: 691-7. PMID 24976443 DOI: 10.1016/j.jaad.2014.04.068  0.64
2014 Zhang X, Kelly JW. Chaperonins resculpt folding free energy landscapes to avoid kinetic traps and accelerate protein folding. Journal of Molecular Biology. 426: 2736-8. PMID 24909364 DOI: 10.1016/j.jmb.2014.06.001  1
2014 McCormack CJ, Conyers RK, Scolyer RA, Kirkwood J, Speakman D, Wong N, Kelly JW, Henderson MA. Atypical Spitzoid neoplasms: a review of potential markers of biological behavior including sentinel node biopsy. Melanoma Research. 24: 437-47. PMID 24892957 DOI: 10.1097/CMR.0000000000000084  0.64
2014 Lin MJ, Pan Y, Jalilian C, Kelly JW. Dermoscopic characteristics of nodular squamous cell carcinoma and keratoacanthoma. Dermatology Practical & Conceptual. 4: 9-15. PMID 24855567 DOI: 10.5826/dpc.0402a02  0.64
2014 Rappley I, Monteiro C, Novais M, Baranczak A, Solis G, Wiseman RL, Helmke S, Maurer MS, Coelho T, Powers ET, Kelly JW. Quantification of transthyretin kinetic stability in human plasma using subunit exchange. Biochemistry. 53: 1993-2006. PMID 24661308 DOI: 10.1021/bi500171j  1
2014 Kelly JW, Hammel WW, Siegel ZD, Sjolund LA. Recalibration of perceived distance in virtual environments occurs rapidly and transfers asymmetrically across scale. Ieee Transactions On Visualization and Computer Graphics. 20: 588-95. PMID 24650986 DOI: 10.1109/TVCG.2014.36  0.8
2014 Sjolund LA, Erdman M, Kelly JW. Collaborative inhibition in spatial memory retrieval. Memory & Cognition. 42: 876-85. PMID 24622929 DOI: 10.3758/s13421-014-0407-0  0.8
2014 Liu Y, Tan YL, Zhang X, Bhabha G, Ekiert DC, Genereux JC, Cho Y, Kipnis Y, Bjelic S, Baker D, Kelly JW. Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts. Proceedings of the National Academy of Sciences of the United States of America. 111: 4449-54. PMID 24591605 DOI: 10.1073/pnas.1323268111  1
2014 Abikhair MR, Mahar PD, Cachia AR, Kelly JW. Liability in the context of misdiagnosis of melanoma in Australia. The Medical Journal of Australia. 200: 119-21. PMID 24484118 DOI: 10.5694/mja13.10239  0.64
2014 Kelly JW, Shen S, Pan Y, Dowling J, McLean CA. Postexcisional melanocytic regrowth extending beyond the initial scar: a novel clinical sign of melanoma. The British Journal of Dermatology. 170: 961-4. PMID 24328996 DOI: 10.1111/bjd.12780  0.64
2014 Lin MJ, Mar V, McLean C, Wolfe R, Kelly JW. Diagnostic accuracy of malignant melanoma according to subtype. The Australasian Journal of Dermatology. 55: 35-42. PMID 24283461 DOI: 10.1111/ajd.12121  0.64
2014 Adamou C, Avraamides MN, Kelly JW. Integration of visuospatial information encoded from different viewpoints. Psychonomic Bulletin & Review. 21: 659-65. PMID 24186271 DOI: 10.3758/s13423-013-0538-5  0.8
2014 Baranczak A, Connelly S, Liu Y, Choi S, Grimster NP, Powers ET, Wilson IA, Kelly JW. Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn. Biopolymers. 101: 484-95. PMID 24105107 DOI: 10.1002/bip.22407  1
2014 Avraamides MN, Sarrou M, Kelly JW. Cross-sensory reference frame transfer in spatial memory: the case of proprioceptive learning. Memory & Cognition. 42: 496-507. PMID 24101554 DOI: 10.3758/s13421-013-0373-y  0.8
2014 Marsh WE, Kelly JW, Dickerson J, Oliver JH. Fuzzy navigation engine: Mitigating the cognitive demands of semi-natural locomotion Presence: Teleoperators and Virtual Environments. 23: 300-319. DOI: 10.1162/PRES_a_00195  0.8
2014 Casallas JS, Oliver JH, Kelly JW, Merienne F, Garbaya S. Using relative head and hand-target features to predict intention in 3D moving-target selection Proceedings - Ieee Virtual Reality. 51-56. DOI: 10.1109/VR.2014.6802050  0.8
2013 Berk JL, Suhr OB, Obici L, Sekijima Y, Zeldenrust SR, Yamashita T, Heneghan MA, Gorevic PD, Litchy WJ, Wiesman JF, Nordh E, Corato M, Lozza A, Cortese A, Robinson-Papp J, ... ... Kelly JW, et al. Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial. Jama. 310: 2658-67. PMID 24368466 DOI: 10.1001/jama.2013.283815  1
2013 Li X, Zhang X, Ladiwala AR, Du D, Yadav JK, Tessier PM, Wright PE, Kelly JW, Buxbaum JN. Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19423-33. PMID 24336709 DOI: 10.1523/JNEUROSCI.2561-13.2013  1
2013 Suh EH, Liu Y, Connelly S, Genereux JC, Wilson IA, Kelly JW. Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. Journal of the American Chemical Society. 135: 17869-80. PMID 24180271 DOI: 10.1021/ja408230k  1
2013 Bannykh SI, Balch WE, Kelly JW, Page LJ, Shelton GD. Formation of gelsolin amyloid fibrils in the rough endoplasmic reticulum of skeletal muscle in the gelsolin mouse model of inclusion body myositis: comparative analysis to human sporadic inclusion body myositis. Ultrastructural Pathology. 37: 304-11. PMID 24047347 DOI: 10.3109/01913123.2013.810684  1
2013 Nunes RJ, de Oliveira P, Lages A, Becker JD, Marcelino P, Barroso E, Perdigoto R, Kelly JW, Quintas A, Santos SC. Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. The Journal of Biological Chemistry. 288: 31752-60. PMID 24030829 DOI: 10.1074/jbc.M113.469858  1
2013 Myung N, Connelly S, Kim B, Park SJ, Wilson IA, Kelly JW, Choi S. Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors. Chemical Communications (Cambridge, England). 49: 9188-90. PMID 23989101 DOI: 10.1039/c3cc44667k  1
2013 Coelho T, Maia LF, da Silva AM, Cruz MW, Planté-Bordeneuve V, Suhr OB, Conceiçao I, Schmidt HH, Trigo P, Kelly JW, Labaudinière R, Chan J, Packman J, Grogan DR. Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy. Journal of Neurology. 260: 2802-14. PMID 23974642 DOI: 10.1007/s00415-013-7051-7  1
2013 Murray AN, Palhano FL, Bieschke J, Kelly JW. Surface adsorption considerations when working with amyloid fibrils in multiwell plates and Eppendorf tubes. Protein Science : a Publication of the Protein Society. 22: 1531-41. PMID 23963844 DOI: 10.1002/pro.2339  1
2013 Kelly JW, Donaldson LS, Sjolund LA, Freiberg JB. More than just perception-action recalibration: walking through a virtual environment causes rescaling of perceived space. Attention, Perception & Psychophysics. 75: 1473-85. PMID 23839015 DOI: 10.3758/s13414-013-0503-4  0.8
2013 Mar VJ, Wong SQ, Li J, Scolyer RA, McLean C, Papenfuss AT, Tothill RW, Kakavand H, Mann GJ, Thompson JF, Behren A, Cebon JS, Wolfe R, Kelly JW, Dobrovic A, et al. BRAF/NRAS wild-type melanomas have a high mutation load correlating with histologic and molecular signatures of UV damage. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 4589-98. PMID 23833303 DOI: 10.1158/1078-0432.CCR-13-0398  0.64
2013 Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, ... ... Kelly JW, et al. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proceedings of the National Academy of Sciences of the United States of America. 110: E2518-27. PMID 23776240 DOI: 10.1073/pnas.1306832110  1
2013 Chen W, Enck S, Price JL, Powers DL, Powers ET, Wong CH, Dyson HJ, Kelly JW. Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins. Journal of the American Chemical Society. 135: 9877-84. PMID 23742246 DOI: 10.1021/ja4040472  1
2013 Penchala SC, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proceedings of the National Academy of Sciences of the United States of America. 110: 9992-7. PMID 23716704 DOI: 10.1073/pnas.1300761110  1
2013 Kelly JW, Siewiorek DP, Smailagic A, Wang W. Automated filtering of common-mode artifacts in multichannel physiological recordings. Ieee Transactions On Bio-Medical Engineering. 60: 2760-70. PMID 23708770 DOI: 10.1109/TBME.2013.2264722  0.4
2013 Shoulders MD, Ryno LM, Cooley CB, Kelly JW, Wiseman RL. Broadly applicable methodology for the rapid and dosable small molecule-mediated regulation of transcription factors in human cells. Journal of the American Chemical Society. 135: 8129-32. PMID 23682758 DOI: 10.1021/ja402756p  1
2013 Ryno LM, Wiseman RL, Kelly JW. Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases. Current Opinion in Chemical Biology. 17: 346-52. PMID 23647985 DOI: 10.1016/j.cbpa.2013.04.009  1
2013 Palhano FL, Lee J, Grimster NP, Kelly JW. Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils. Journal of the American Chemical Society. 135: 7503-10. PMID 23611538 DOI: 10.1021/ja3115696  1
2013 Shoulders MD, Ryno LM, Genereux JC, Moresco JJ, Tu PG, Wu C, Yates JR, Su AI, Kelly JW, Wiseman RL. Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments. Cell Reports. 3: 1279-92. PMID 23583182 DOI: 10.1016/j.celrep.2013.03.024  1
2013 Jalilian C, Chamberlain AJ, Haskett M, Rosendahl C, Goh M, Beck H, Keir J, Varghese P, Mar A, Hosking S, Hussain I, Rich M, McLean C, Kelly JW. Clinical and dermoscopic characteristics of Merkel cell carcinoma. The British Journal of Dermatology. 169: 294-7. PMID 23574613 DOI: 10.1111/bjd.12376  0.64
2013 Ong DS, Wang YJ, Tan YL, Yates JR, Mu TW, Kelly JW. FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher disease fibroblasts. Chemistry & Biology. 20: 403-15. PMID 23434032 DOI: 10.1016/j.chembiol.2012.11.014  1
2013 Wang W, Collinger JL, Degenhart AD, Tyler-Kabara EC, Schwartz AB, Moran DW, Weber DJ, Wodlinger B, Vinjamuri RK, Ashmore RC, Kelly JW, Boninger ML. An electrocorticographic brain interface in an individual with tetraplegia. Plos One. 8: e55344. PMID 23405137 DOI: 10.1371/journal.pone.0055344  0.4
2013 Grimster NP, Connelly S, Baranczak A, Dong J, Krasnova LB, Sharpless KB, Powers ET, Wilson IA, Kelly JW. Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate. Journal of the American Chemical Society. 135: 5656-68. PMID 23350654 DOI: 10.1021/ja311729d  1
2013 Jaimes N, Chen L, Dusza SW, Carrera C, Puig S, Thomas L, Kelly JW, Dang L, Zalaudek I, Braun RP, Menzies SW, Busam KJ, Marghoob AA. Clinical and dermoscopic characteristics of desmoplastic melanomas. Jama Dermatology. 149: 413-21. PMID 23325288 DOI: 10.1001/jamadermatol.2013.2248  0.64
2013 Lim KH, Dyson HJ, Kelly JW, Wright PE. Localized structural fluctuations promote amyloidogenic conformations in transthyretin. Journal of Molecular Biology. 425: 977-88. PMID 23318953 DOI: 10.1016/j.jmb.2013.01.008  1
2013 Kelly JW, Sjolund LA, Sturz BR. Geometric cues, reference frames, and the equivalence of experienced-aligned and novel-aligned views in human spatial memory. Cognition. 126: 459-74. PMID 23305700 DOI: 10.1016/j.cognition.2012.11.007  0.8
2013 Hulleman JD, Brown SJ, Rosen H, Kelly JW. A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion. Journal of Biomolecular Screening. 18: 647-58. PMID 23230284 DOI: 10.1177/1087057112469405  1
2013 Mar V, Roberts H, Wolfe R, English DR, Kelly JW. Nodular melanoma: a distinct clinical entity and the largest contributor to melanoma deaths in Victoria, Australia. Journal of the American Academy of Dermatology. 68: 568-75. PMID 23182058 DOI: 10.1016/j.jaad.2012.09.047  0.64
2013 Greenauer N, Mello C, Kelly JW, Avraamides MN. Integrating spatial information across experiences. Psychological Research. 77: 540-54. PMID 22941360 DOI: 10.1007/s00426-012-0452-x  0.8
2013 Marsh WE, Kelly JW, Dark VJ, Oliver JH. Cognitive demands of semi-natural virtual locomotion Presence: Teleoperators and Virtual Environments. 22: 216-234. DOI: 10.1162/PRES_a_00152  0.8
2013 Kelly JW, Burton M, Pollock B, Rubio E, Curtis M, De La Cruz J, Gilbert S, Winer E. Space perception in virtual environments: Displacement from the center of projection causes less distortion than predicted by cue-based models Acm Transactions On Applied Perception. 10. DOI: 10.1145/2536764.2536765  0.8
2013 Casallas JS, Oliver JH, Kelly JW, Merienne F, Garbaya S. Towards a model for predicting intention in 3D moving-target selection tasks Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 8019: 13-22. DOI: 10.1007/978-3-642-39360-0-2  0.8
2013 Fearns C, Connelly S, Powers ET, Kelly JW. Development of Therapeutic Strategies for the Transthyretin Amyloidoses Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties. 373-394. DOI: 10.1002/9783527654185.ch17  1
2013 Lin MJ, Kelly JW. When is it melanoima? An update on diagnosis and management Medicine Today. 14: 44-53.  0.64
2012 Kelly JW, Degenhart AD, Siewiorek DP, Smailagic A, Wang W. Sparse linear regression with elastic net regularization for brain-computer interfaces. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2012: 4275-8. PMID 23366872 DOI: 10.1109/EMBC.2012.6346911  0.4
2012 Fowler DM, Kelly JW. Functional amyloidogenesis and cytotoxicity-insights into biology and pathology. Plos Biology. 10: e1001459. PMID 23300381 DOI: 10.1371/journal.pbio.1001459  1
2012 Murray AN, Kelly JW. Hsp104 gives clients the individual attention they need. Cell. 151: 695-7. PMID 23141530 DOI: 10.1016/j.cell.2012.10.033  1
2012 Araya CL, Fowler DM, Chen W, Muniez I, Kelly JW, Fields S. A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function. Proceedings of the National Academy of Sciences of the United States of America. 109: 16858-63. PMID 23035249 DOI: 10.1073/pnas.1209751109  1
2012 Azevedo EP, Guimarães-Costa AB, Torezani GS, Braga CA, Palhano FL, Kelly JW, Saraiva EM, Foguel D. Amyloid fibrils trigger the release of neutrophil extracellular traps (NETs), causing fibril fragmentation by NET-associated elastase. The Journal of Biological Chemistry. 287: 37206-18. PMID 22918834 DOI: 10.1074/jbc.M112.369942  1
2012 Hulleman JD, Balch WE, Kelly JW. Translational attenuation differentially alters the fate of disease-associated fibulin proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4548-60. PMID 22872678 DOI: 10.1096/fj.11-202861  1
2012 Coelho T, Maia LF, Martins da Silva A, Waddington Cruz M, Planté-Bordeneuve V, Lozeron P, Suhr OB, Campistol JM, Conceição IM, Schmidt HH, Trigo P, Kelly JW, Labaudinière R, Chan J, Packman J, et al. Tafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial. Neurology. 79: 785-92. PMID 22843282 DOI: 10.1212/WNL.0b013e3182661eb1  1
2012 Price JL, Culyba EK, Chen W, Murray AN, Hanson SR, Wong CH, Powers ET, Kelly JW. N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability. Biopolymers. 98: 195-211. PMID 22782562 DOI: 10.1002/bip.22030  1
2012 Bulawa CE, Connelly S, Devit M, Wang L, Weigel C, Fleming JA, Packman J, Powers ET, Wiseman RL, Foss TR, Wilson IA, Kelly JW, Labaudinière R. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proceedings of the National Academy of Sciences of the United States of America. 109: 9629-34. PMID 22645360 DOI: 10.1073/pnas.1121005109  1
2012 Berk JL, Suhr OB, Sekijima Y, Yamashita T, Heneghan M, Zeldenrust SR, Ando Y, Ikeda S, Gorevic P, Merlini G, Kelly JW, Skinner M, Bisbee AB, Dyck PJ, Obici L, et al. The Diflunisal Trial: study accrual and drug tolerance. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 19: 37-8. PMID 22551208 DOI: 10.3109/13506129.2012.678509  1
2012 Price JL, Shental-Bechor D, Dhar A, Turner MJ, Powers ET, Gruebele M, Levy Y, Kelly JW. Correction to Context-Dependent Effects of Asparagine Glycosylation on Pin WW Folding Kinetics and Thermodynamics. Journal of the American Chemical Society. 134: 4450-4451. PMID 22500055 DOI: 10.1021/ja300899d  1
2012 Pollock B, Burton M, Kelly JW, Gilbert S, Winer E. The right view from the wrong location: depth perception in stereoscopic multi-user virtual environments. Ieee Transactions On Visualization and Computer Graphics. 18: 581-8. PMID 22402685 DOI: 10.1109/TVCG.2012.58  0.8
2012 Solomon JP, Page LJ, Balch WE, Kelly JW. Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention. Critical Reviews in Biochemistry and Molecular Biology. 47: 282-96. PMID 22360545 DOI: 10.3109/10409238.2012.661401  1
2012 Bett C, Joshi-Barr S, Lucero M, Trejo M, Liberski P, Kelly JW, Masliah E, Sigurdson CJ. Biochemical properties of highly neuroinvasive prion strains. Plos Pathogens. 8: e1002522. PMID 22319450 DOI: 10.1371/journal.ppat.1002522  1
2012 Carpenter SK, Kelly JW. Tests enhance retention and transfer of spatial learning. Psychonomic Bulletin & Review. 19: 443-8. PMID 22318460 DOI: 10.3758/s13423-012-0221-2  0.8
2012 Johnson SM, Connelly S, Fearns C, Powers ET, Kelly JW. The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug. Journal of Molecular Biology. 421: 185-203. PMID 22244854 DOI: 10.1016/j.jmb.2011.12.060  1
2012 Allison BZ, Leeb R, Brunner C, Müller-Putz GR, Bauernfeind G, Kelly JW, Neuper C. Toward smarter BCIs: extending BCIs through hybridization and intelligent control. Journal of Neural Engineering. 9: 013001. PMID 22156029 DOI: 10.1088/1741-2560/9/1/013001  0.4
2012 Fowler DM, Koulov AV, Kelly JW, Balch WE. Mammalian functional amyloid The Functional Fold: Amyloid Structures in Nature. 147-158. DOI: 10.4032/9789814267625  1
2012 Boonsuk W, Gilbert SB, Kelly JW. The impact of three interfaces for 360-degree video on spatial cognition Conference On Human Factors in Computing Systems - Proceedings. 2579-2588. DOI: 10.1145/2207676.2208647  0.8
2012 Marsh WE, Kelly JW, Dark VJ, Oliver JH. The cognitive implications of virtual locomotion with a restricted field of view Proceedings of Spie - the International Society For Optical Engineering. 8289. DOI: 10.1117/12.912197  0.8
2012 Burton M, Pollock B, Kelly JW, Gilbert S, Winer E, De La Cruz J. Diagnosing perceptual distortion present in group stereoscopic viewing Proceedings of Spie - the International Society For Optical Engineering. 8291. DOI: 10.1117/12.912184  0.8
2012 Gilbert S, Boonsuk W, Kelly JW. Virtual displays for 360-degree video Proceedings of Spie - the International Society For Optical Engineering. 8291. DOI: 10.1117/12.912173  0.8
2012 Marsh WE, Putnam M, Kelly JW, Dark VJ, Oliver JH. The cognitive implications of semi-natural virtual locomotion Proceedings - Ieee Virtual Reality. 47-50. DOI: 10.1109/VR.2012.6180878  0.8
2012 Ly L, Winship I, Kelly JW. Reply Journal of the American Academy of Dermatology. 66: 325-326. DOI: 10.1016/j.jaad.2011.08.029  0.64
2012 Avraamides MN, Adamou C, Galati A, Kelly JW. Integration of spatial relations across perceptual experiences Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 7463: 416-430. DOI: 10.1007/978-3-642-32732-2_27  0.8
2011 Davis PG, Serpell JW, Kelly JW, Paul E. Axillary lymph node dissection for malignant melanoma. Anz Journal of Surgery. 81: 462-6. PMID 22295351 DOI: 10.1111/j.1445-2197.2010.05491.x  0.64
2011 Kelly JW, Collinger JL, Degenhart AD, Siewiorek DP, Smailagic A, Wang W. Frequency tracking and variable bandwidth for line noise filtering without a reference. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2011: 7908-11. PMID 22256174 DOI: 10.1109/IEMBS.2011.6091950  0.4
2011 Degenhart AD, Collinger JL, Vinjamuri R, Kelly JW, Tyler-Kabara EC, Wang W. Classification of hand posture from electrocorticographic signals recorded during varying force conditions. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2011: 5782-5. PMID 22255654 DOI: 10.1109/IEMBS.2011.6091431  0.4
2011 Holtzman DM, Goate A, Kelly J, Sperling R. Mapping the road forward in Alzheimer's disease. Science Translational Medicine. 3: 114ps48. PMID 22190237 DOI: 10.1126/scitranslmed.3003529  1
2011 Kelly JW. Finally, a transgenic light chain amyloidosis mouse model. Blood. 118: 6479-80. PMID 22174305 DOI: 10.1182/blood-2011-10-386532  1
2011 Azevedo EP, Pereira HM, Garratt RC, Kelly JW, Foguel D, Palhano FL. Dissecting the structure, thermodynamic stability, and aggregation properties of the A25T transthyretin (A25T-TTR) variant involved in leptomeningeal amyloidosis: identifying protein partners that co-aggregate during A25T-TTR fibrillogenesis in cerebrospinal fluid. Biochemistry. 50: 11070-83. PMID 22091638 DOI: 10.1021/bi201365r  1
2011 Orwig SD, Tan YL, Grimster NP, Yu Z, Powers ET, Kelly JW, Lieberman RL. Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease. Biochemistry. 50: 10647-57. PMID 22047104 DOI: 10.1021/bi201619z  1
2011 Hulleman JD, Kaushal S, Balch WE, Kelly JW. Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration. Molecular Biology of the Cell. 22: 4765-75. PMID 22031286 DOI: 10.1091/mbc.E11-08-0695  1
2011 Ly L, Kelly JW, O'Keefe R, Sutton T, Dowling JP, Swain S, Byrne M, Curr N, Wolfe R, Chamberlain A, Haskett M. Efficacy of imiquimod cream, 5%, for lentigo maligna after complete excision: a study of 43 patients. Archives of Dermatology. 147: 1191-5. PMID 22006136 DOI: 10.1001/archdermatol.2011.260  0.64
2011 Kelly JW, Avraamides MN, Giudice NA. Haptic experiences influence visually acquired memories: reference frames during multimodal spatial learning. Psychonomic Bulletin & Review. 18: 1119-25. PMID 21956382 DOI: 10.3758/s13423-011-0162-1  0.8
2011 Price JL, Powers ET, Kelly JW. N-PEGylation of a reverse turn is stabilizing in multiple sequence contexts, unlike N-GlcNAcylation. Acs Chemical Biology. 6: 1188-92. PMID 21939258 DOI: 10.1021/cb200277u  1
2011 Lindquist SL, Kelly JW. Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis. Cold Spring Harbor Perspectives in Biology. 3. PMID 21900404 DOI: 10.1101/cshperspect.a004507  1
2011 Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA. Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Science Translational Medicine. 3: 97ra81. PMID 21865539 DOI: 10.1126/scitranslmed.3002473  1
2011 Berk JL, Dyck PJ, Obici L, Zeldenrust SR, Sekijima Y, Yamashita T, Ando Y, Ikeda SI, Gorevic P, Merlini G, Kelly JW, Skinner M, Bisbee AB, Suhr OB. The diflunisal trial: update on study drug tolerance and disease progression. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 18: 196-7. PMID 21838485 DOI: 10.3109/13506129.2011.574354073  1
2011 Price JL, Powers DL, Powers ET, Kelly JW. Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts. Proceedings of the National Academy of Sciences of the United States of America. 108: 14127-32. PMID 21825145 DOI: 10.1073/pnas.1105880108  1
2011 Lee J, Culyba EK, Powers ET, Kelly JW. Amyloid-β forms fibrils by nucleated conformational conversion of oligomers. Nature Chemical Biology. 7: 602-9. PMID 21804535 DOI: 10.1038/nchembio.624  1
2011 Vinjamuri R, Weber DJ, Mao ZH, Collinger JL, Degenhart AD, Kelly JW, Boninger ML, Tyler-Kabara EC, Wang W. Toward synergy-based brain-machine interfaces. Ieee Transactions On Information Technology in Biomedicine : a Publication of the Ieee Engineering in Medicine and Biology Society. 15: 726-36. PMID 21708506 DOI: 10.1109/TITB.2011.2160272  0.4
2011 Degenhart AD, Kelly JW, Ashmore RC, Collinger JL, Tyler-Kabara EC, Weber DJ, Wang W. Craniux: a LabVIEW-based modular software framework for brain-machine interface research. Computational Intelligence and Neuroscience. 2011: 363565. PMID 21687575 DOI: 10.1155/2011/363565  0.4
2011 Reinhart PH, Kelly JW. Treating the periphery to ameliorate neurodegenerative diseases. Cell. 145: 813-4. PMID 21663784 DOI: 10.1016/j.cell.2011.05.031  1
2011 Mar V, Wolfe R, Kelly JW. Predicting melanoma risk for the Australian population. The Australasian Journal of Dermatology. 52: 109-16. PMID 21605094 DOI: 10.1111/j.1440-0960.2010.00727.x  0.64
2011 Ly L, Christie M, Swain S, Winship I, Kelly JW. Melanoma(s) arising in large segmental speckled lentiginous nevi: a case series. Journal of the American Academy of Dermatology. 64: 1190-3. PMID 21571187 DOI: 10.1016/j.jaad.2010.12.019  0.64
2011 Bourgault S, Choi S, Buxbaum JN, Kelly JW, Price JL, Reixach N. Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs. Biochemical and Biophysical Research Communications. 410: 707-13. PMID 21557933 DOI: 10.1016/j.bbrc.2011.04.133  1
2011 Kelly JW. Head for the hills: the influence of environmental slant on spatial memory organization. Psychonomic Bulletin & Review. 18: 774-80. PMID 21538203 DOI: 10.3758/s13423-011-0100-2  0.8
2011 Wiseman RL, Kelly JW. Cell biology. Phosphatase inhibition delays translational recovery. Science (New York, N.Y.). 332: 44-5. PMID 21454777 DOI: 10.1126/science.1204505  1
2011 Solomon JP, Bourgault S, Powers ET, Kelly JW. Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension. Biochemistry. 50: 2486-98. PMID 21348501 DOI: 10.1021/bi101905n  1
2011 Culyba EK, Price JL, Hanson SR, Dhar A, Wong CH, Gruebele M, Powers ET, Kelly JW. Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns. Science (New York, N.Y.). 331: 571-5. PMID 21292975 DOI: 10.1126/science.1198461  1
2011 Choi S, Kelly JW. A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin. Bioorganic & Medicinal Chemistry. 19: 1505-14. PMID 21273081 DOI: 10.1016/j.bmc.2010.12.050  1
2011 Du D, Murray AN, Cohen E, Kim HE, Simkovsky R, Dillin A, Kelly JW. A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues. Biochemistry. 50: 1607-17. PMID 21268584 DOI: 10.1021/bi1013744  1
2011 Kelly JW, Avraamides MN. Cross-sensory transfer of reference frames in spatial memory. Cognition. 118: 444-50. PMID 21227408 DOI: 10.1016/j.cognition.2010.12.006  0.8
2011 Bourgault S, Solomon JP, Reixach N, Kelly JW. Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion. Biochemistry. 50: 1001-15. PMID 21194234 DOI: 10.1021/bi101822y  1
2011 Ong DS, Kelly JW. Chemical and/or biological therapeutic strategies to ameliorate protein misfolding diseases. Current Opinion in Cell Biology. 23: 231-8. PMID 21146391 DOI: 10.1016/j.ceb.2010.11.002  1
2011 Kelly JW, Siewiorek DP, Smailagic A, Collinger JL, Weber DJ, Wang W. Fully automated reduction of ocular artifacts in high-dimensional neural data. Ieee Transactions On Bio-Medical Engineering. 58: 598-606. PMID 21097374 DOI: 10.1109/TBME.2010.2093932  0.4
2011 Marsh WE, Kelly JW, Dark VJ, Oliver JH. Assessing the use of cognitive resources in virtual reality Communications in Computer and Information Science. 174: 120-124. DOI: 10.1007/978-3-642-22095-1_25  0.8
2010 Choi S, Ong DS, Kelly JW. A stilbene that binds selectively to transthyretin in cells and remains dark until it undergoes a chemoselective reaction to create a bright blue fluorescent conjugate. Journal of the American Chemical Society. 132: 16043-51. PMID 20964336 DOI: 10.1021/ja104999v  1
2010 Price JL, Shental-Bechor D, Dhar A, Turner MJ, Powers ET, Gruebele M, Levy Y, Kelly JW. Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics. Journal of the American Chemical Society. 132: 15359-67. PMID 20936810 DOI: 10.1021/ja106896t  1
2010 Kelly JW, McNamara TP. Reference frames during the acquisition and development of spatial memories. Cognition. 116: 409-20. PMID 20591422 DOI: 10.1016/j.cognition.2010.06.002  0.8
2010 Ong DS, Mu TW, Palmer AE, Kelly JW. Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis. Nature Chemical Biology. 6: 424-32. PMID 20453863 DOI: 10.1038/nchembio.368  1
2010 Avraamides MN, Kelly JW. Multiple systems of spatial memory: evidence from described scenes. Journal of Experimental Psychology. Learning, Memory, and Cognition. 36: 635-45. PMID 20438262 DOI: 10.1037/a0017040  0.8
2010 Ng JC, Swain S, Dowling JP, Wolfe R, Simpson P, Kelly JW. The impact of partial biopsy on histopathologic diagnosis of cutaneous melanoma: experience of an Australian tertiary referral service. Archives of Dermatology. 146: 234-9. PMID 20231492 DOI: 10.1001/archdermatol.2010.14  0.32
2010 Trivella DB, Bleicher L, Palmieri Lde C, Wiggers HJ, Montanari CA, Kelly JW, Lima LM, Foguel D, Polikarpov I. Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding. Journal of Structural Biology. 170: 522-31. PMID 20211733 DOI: 10.1016/j.jsb.2010.03.002  1
2010 Murray AN, Solomon JP, Wang YJ, Balch WE, Kelly JW. Discovery and characterization of a mammalian amyloid disaggregation activity. Protein Science : a Publication of the Protein Society. 19: 836-46. PMID 20162625 DOI: 10.1002/pro.363  1
2010 Connelly S, Choi S, Johnson SM, Kelly JW, Wilson IA. Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses. Current Opinion in Structural Biology. 20: 54-62. PMID 20133122 DOI: 10.1016/j.sbi.2009.12.009  1
2010 Choi S, Connelly S, Reixach N, Wilson IA, Kelly JW. Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma. Nature Chemical Biology. 6: 133-9. PMID 20081815 DOI: 10.1038/nchembio.281  1
2010 Choi S, Reixach N, Connelly S, Johnson SM, Wilson IA, Kelly JW. A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. Journal of the American Chemical Society. 132: 1359-70. PMID 20043671 DOI: 10.1021/ja908562q  1
2010 Cohen E, Du D, Joyce D, Kapernick EA, Volovik Y, Kelly JW, Dillin A. Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection. Aging Cell. 9: 126-34. PMID 20003171 DOI: 10.1111/j.1474-9726.2009.00541.x  1
2010 Hutt DM, Herman D, Rodrigues AP, Noel S, Pilewski JM, Matteson J, Hoch B, Kellner W, Kelly JW, Schmidt A, Thomas PJ, Matsumura Y, Skach WR, Gentzsch M, Riordan JR, et al. Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nature Chemical Biology. 6: 25-33. PMID 19966789 DOI: 10.1038/nchembio.275  1
2010 Koob AO, Ubhi K, Paulsson JF, Kelly J, Rockenstein E, Mante M, Adame A, Masliah E. Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies. Experimental Neurology. 221: 267-74. PMID 19944097 DOI: 10.1016/j.expneurol.2009.11.015  1
2010 Ramirez-Alvarado M, Kelly JW, Dobson CM. Preface Protein Misfolding Diseases: Current and Emerging Principles and Therapies. xxv-xxvi. DOI: 10.1098/rstb.1995.0038  1
2010 Kelly JW, Avraamides MN, McNamara TP. Reference frames influence spatial memory development within and across sensory modalities Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 6222: 222-233. DOI: 10.1007/978-3-642-14749-4_20  0.8
2010 Naik S, Haque I, Degner N, Kornilayev B, Bomhoff G, Hodges J, Khorassani AA, Katayama H, Morris J, Kelly J, Seed J, Fisher MT. Identifying protein stabilizing ligands using GroEL Biopolymers. 93: 237-251. DOI: 10.1002/bip.21319  1
2010 Johnson SM, Wiseman L, Paulsson JF, Choi S, Powers ET, Buxbaum JN, Kelly JW. Understanding and Ameliorating the TTR Amyloidoses Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 967-1003. DOI: 10.1002/9780470572702.ch45  1
2009 Wiseman RL, Kelly JW. Evolving protein stability through genetic selection. Molecular Cell. 36: 730-1. PMID 20005835 DOI: 10.1016/j.molcel.2009.11.023  1
2009 Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell. 139: 1157-69. PMID 20005808 DOI: 10.1016/j.cell.2009.11.014  1
2009 Solomon JP, Yonemoto IT, Murray AN, Price JL, Powers ET, Balch WE, Kelly JW. The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic. Biochemistry. 48: 11370-80. PMID 19904968 DOI: 10.1021/bi901368e  1
2009 Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW. Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 106: 18563-8. PMID 19841277 DOI: 10.1073/pnas.0804758106  1
2009 Watt B, van Niel G, Fowler DM, Hurbain I, Luk KC, Stayrook SE, Lemmon MA, Raposo G, Shorter J, Kelly JW, Marks MS. N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. The Journal of Biological Chemistry. 284: 35543-55. PMID 19840945 DOI: 10.1074/jbc.M109.047449  1
2009 Bieschke J, Cohen E, Murray A, Dillin A, Kelly JW. A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis. Protein Science : a Publication of the Protein Society. 18: 2231-41. PMID 19701939 DOI: 10.1002/pro.234  1
2009 Yonemoto IT, Wood MR, Balch WE, Kelly JW. A general strategy for the bacterial expression of amyloidogenic peptides using BCL-XL-1/2 fusions. Protein Science : a Publication of the Protein Society. 18: 1978-86. PMID 19621381 DOI: 10.1002/pro.211  1
2009 Jäger M, Dendle M, Kelly JW. Sequence determinants of thermodynamic stability in a WW domain--an all-beta-sheet protein. Protein Science : a Publication of the Protein Society. 18: 1806-13. PMID 19565466 DOI: 10.1002/pro.172  0.64
2009 Page LJ, Suk JY, Bazhenova L, Fleming SM, Wood M, Jiang Y, Guo LT, Mizisin AP, Kisilevsky R, Shelton GD, Balch WE, Kelly JW. Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins. Proceedings of the National Academy of Sciences of the United States of America. 106: 11125-30. PMID 19549824 DOI: 10.1073/pnas.0811753106  1
2009 Fuller AA, Du D, Liu F, Davoren JE, Bhabha G, Kroon G, Case DA, Dyson HJ, Powers ET, Wipf P, Gruebele M, Kelly JW. Evaluating beta-turn mimics as beta-sheet folding nucleators. Proceedings of the National Academy of Sciences of the United States of America. 106: 11067-72. PMID 19541614 DOI: 10.1073/pnas.0813012106  1
2009 Gao J, Bosco DA, Powers ET, Kelly JW. Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins. Nature Structural & Molecular Biology. 16: 684-90. PMID 19525973 DOI: 10.1038/nsmb.1610  1
2009 Bunagan MR, Gao J, Kelly JW, Gai F. Probing the folding transition state structure of the villin headpiece subdomain via side chain and backbone mutagenesis. Journal of the American Chemical Society. 131: 7470-6. PMID 19425552 DOI: 10.1021/ja901860f  1
2009 Fowler DM, Kelly JW. Aggregating knowledge about prions and amyloid. Cell. 137: 20-2. PMID 19345180 DOI: 10.1016/j.cell.2009.03.030  1
2009 Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE. Biological and chemical approaches to diseases of proteostasis deficiency. Annual Review of Biochemistry. 78: 959-91. PMID 19298183 DOI: 10.1146/annurev.biochem.052308.114844  1
2009 Kelly JW, McNamara TP. Facilitated pointing to remembered objects in front: evidence for egocentric retrieval or for spatial priming? Psychonomic Bulletin & Review. 16: 295-300. PMID 19293097 DOI: 10.3758/PBR.16.2.295  0.8
2009 Hanson SR, Culyba EK, Hsu TL, Wong CH, Kelly JW, Powers ET. The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability. Proceedings of the National Academy of Sciences of the United States of America. 106: 3131-6. PMID 19204290 DOI: 10.1073/pnas.0810318105  1
2009 Johnson SM, Connelly S, Wilson IA, Kelly JW. Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. Journal of Medicinal Chemistry. 52: 1115-25. PMID 19191553 DOI: 10.1021/jm801347s  1
2009 Kelly JW, McNamara TP, Bodenheimer B, Carr TH, Rieser JJ. Individual differences in using geometric and featural cues to maintain spatial orientation: cue quantity and cue ambiguity are more important than cue type. Psychonomic Bulletin & Review. 16: 176-81. PMID 19145030 DOI: 10.3758/PBR.16.1.176  0.8
2008 Sekijima Y, Kelly JW, Ikeda S. Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses. Current Pharmaceutical Design. 14: 3219-30. PMID 19075702 DOI: 10.2174/138161208786404155  1
2008 Loomis JM, Kelly JW, Pusch M, Bailenson JN, Beall AC. Psychophysics of perceiving eye-gaze and head direction with peripheral vision: implications for the dynamics of eye-gaze behavior. Perception. 37: 1443-57. PMID 18986070 DOI: 10.1068/p5896  0.8
2008 Kelly JW, McNamara TP, Bodenheimer B, Carr TH, Rieser JJ. The shape of human navigation: how environmental geometry is used in maintenance of spatial orientation. Cognition. 109: 281-6. PMID 18952206 DOI: 10.1016/j.cognition.2008.09.001  0.8
2008 Jager M, Deechongkit S, Koepf EK, Nguyen H, Gao J, Powers ET, Gruebele M, Kelly JW. Understanding the mechanism of beta-sheet folding from a chemical and biological perspective. Biopolymers. 90: 751-8. PMID 18844292 DOI: 10.1002/bip.21101  1
2008 Johnson SM, Connelly S, Wilson IA, Kelly JW. Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. Journal of Medicinal Chemistry. 51: 6348-58. PMID 18811132 DOI: 10.1021/jm800435s  1
2008 Mu TW, Ong DS, Wang YJ, Balch WE, Yates JR, Segatori L, Kelly JW. Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell. 134: 769-81. PMID 18775310 DOI: 10.1016/j.cell.2008.06.037  1
2008 Yonemoto IT, Kroon GJ, Dyson HJ, Balch WE, Kelly JW. Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state. Biochemistry. 47: 9900-10. PMID 18710262 DOI: 10.1021/bi800828u  1
2008 Palaninathan SK, Mohamedmohaideen NN, Snee WC, Kelly JW, Sacchettini JC. Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. Journal of Molecular Biology. 382: 1157-67. PMID 18662699 DOI: 10.1016/j.jmb.2008.07.029  1
2008 Kelly JW, McNamara TP. Response mode differences in perspective taking: differences in representation or differences in retrieval? Memory & Cognition. 36: 863-72. PMID 18604967 DOI: 10.3758/MC.36.4.863  0.8
2008 Pan Y, Chamberlain AJ, Bailey M, Chong AH, Haskett M, Kelly JW. Dermatoscopy aids in the diagnosis of the solitary red scaly patch or plaque-features distinguishing superficial basal cell carcinoma, intraepidermal carcinoma, and psoriasis. Journal of the American Academy of Dermatology. 59: 268-74. PMID 18550207 DOI: 10.1016/j.jaad.2008.05.013  0.64
2008 Hurshman Babbes AR, Powers ET, Kelly JW. Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis. Biochemistry. 47: 6969-84. PMID 18537267 DOI: 10.1021/bi800636q  1
2008 Kelly JW, McNamara TP. Spatial memories of virtual environments: how egocentric experience, intrinsic structure, and extrinsic structure interact. Psychonomic Bulletin & Review. 15: 322-7. PMID 18488647 DOI: 10.3758/PBR.15.2.322  0.8
2008 Gao J, Kelly JW. Toward quantification of protein backbone-backbone hydrogen bonding energies: An energetic analysis of an amide-to-ester mutation in an alpha-helix within a protein. Protein Science : a Publication of the Protein Society. 17: 1096-101. PMID 18434500 DOI: 10.1110/ps.083439708  1
2008 Liu W, McArthur GA, Trivett M, Murray WK, Wolfe R, Kelly JW. Correlation of subjective self-reported melanoma growth rate with objective tumor proliferation markers. Archives of Dermatology. 144: 555-6. PMID 18427059 DOI: 10.1001/archderm.144.4.555  0.32
2008 Kelly JW, Riecke B, Loomis JM, Beall AC. Visual control of posture in real and virtual environments. Perception & Psychophysics. 70: 158-65. PMID 18306969 DOI: 10.3758/PP.70.1.158  0.8
2008 Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. Science (New York, N.Y.). 319: 916-9. PMID 18276881 DOI: 10.1126/science.1141448  1
2008 Liu F, Du D, Fuller AA, Davoren JE, Wipf P, Kelly JW, Gruebele M. An experimental survey of the transition between two-state and downhill protein folding scenarios. Proceedings of the National Academy of Sciences of the United States of America. 105: 2369-74. PMID 18268349 DOI: 10.1073/pnas.0711908105  1
2008 Mu TW, Fowler DM, Kelly JW. Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. Plos Biology. 6: e26. PMID 18254660 DOI: 10.1371/journal.pbio.0060026  1
2008 Johnson SM, Connelly S, Wilson IA, Kelly JW. Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. Journal of Medicinal Chemistry. 51: 260-70. PMID 18095641 DOI: 10.1021/jm0708735  1
2008 Bieschke J, Siegel SJ, Fu Y, Kelly JW. Alzheimer's Abeta peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)? Biochemistry. 47: 50-9. PMID 18078350 DOI: 10.1021/bi701757v  1
2008 Reixach N, Foss TR, Santelli E, Pascual J, Kelly JW, Buxbaum JN. Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic. A lesson in the generation of transgenic models of diseases involving oligomeric proteins. The Journal of Biological Chemistry. 283: 2098-107. PMID 18006495 DOI: 10.1074/jbc.M708028200  0.8
2008 Avraamides MN, Kelly JW. Multiple systems of spatial memory and action. Cognitive Processing. 9: 93-106. PMID 17899235 DOI: 10.1007/s10339-007-0188-5  0.8
2007 Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, Schindler M, Wildum S, Chinnadurai R, Rajan D, Specht A, Giménez-Gallego G, Sánchez PC, Fowler DM, Koulov A, Kelly JW, et al. Semen-derived amyloid fibrils drastically enhance HIV infection. Cell. 131: 1059-71. PMID 18083097 DOI: 10.1016/j.cell.2007.10.014  1
2007 Wiseman RL, Powers ET, Buxbaum JN, Kelly JW, Balch WE. An adaptable standard for protein export from the endoplasmic reticulum. Cell. 131: 809-21. PMID 18022373 DOI: 10.1016/j.cell.2007.10.025  1
2007 Kelly JW, Avraamides MN, Loomis JM. Sensorimotor alignment effects in the learning environment and in novel environments. Journal of Experimental Psychology. Learning, Memory, and Cognition. 33: 1092-107. PMID 17983315 DOI: 10.1037/0278-7393.33.6.1092  0.8
2007 Yu Z, Sawkar AR, Kelly JW. Pharmacologic chaperoning as a strategy to treat Gaucher disease. The Febs Journal. 274: 4944-50. PMID 17894779 DOI: 10.1111/j.1742-4658.2007.06042.x  1
2007 Jäger M, Dendle M, Fuller AA, Kelly JW. A cross-strand Trp Trp pair stabilizes the hPin1 WW domain at the expense of function. Protein Science : a Publication of the Protein Society. 16: 2306-13. PMID 17766376 DOI: 10.1110/ps.072904107  1
2007 Wiseman RL, Koulov A, Powers E, Kelly JW, Balch WE. Protein energetics in maturation of the early secretory pathway. Current Opinion in Cell Biology. 19: 359-67. PMID 17686625 DOI: 10.1016/j.ceb.2007.05.005  1
2007 Dillin A, Kelly JW. Medicine. The yin-yang of sirtuins. Science (New York, N.Y.). 317: 461-2. PMID 17656709 DOI: 10.1126/science.1146585  1
2007 Jäger M, Nguyen H, Dendle M, Gruebele M, Kelly JW. Influence of hPin1 WW N-terminal domain boundaries on function, protein stability, and folding. Protein Science : a Publication of the Protein Society. 16: 1495-501. PMID 17586778 DOI: 10.1110/ps.072775507  1
2007 Stewart CR, Wilson LM, Zhang Q, Pham CL, Waddington LJ, Staples MK, Stapleton D, Kelly JW, Howlett GJ. Oxidized cholesterol metabolites found in human atherosclerotic lesions promote apolipoprotein C-II amyloid fibril formation. Biochemistry. 46: 5552-61. PMID 17429947 DOI: 10.1021/bi602554z  1
2007 Fowler DM, Koulov AV, Balch WE, Kelly JW. Functional amyloid--from bacteria to humans. Trends in Biochemical Sciences. 32: 217-24. PMID 17412596 DOI: 10.1016/j.tibs.2007.03.003  1
2007 Siegel SJ, Bieschke J, Powers ET, Kelly JW. The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation. Biochemistry. 46: 1503-10. PMID 17279615 DOI: 10.1021/bi061853s  1
2007 Yu Z, Sawkar AR, Whalen LJ, Wong CH, Kelly JW. Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention. Journal of Medicinal Chemistry. 50: 94-100. PMID 17201413 DOI: 10.1021/jm060677i  1
2006 Liu W, Dowling JP, Murray WK, McArthur GA, Thompson JF, Wolfe R, Kelly JW. Rate of growth in melanomas: characteristics and associations of rapidly growing melanomas. Archives of Dermatology. 142: 1551-8. PMID 17178980 DOI: 10.1001/archderm.142.12.1551  0.32
2006 Fu Y, Gao J, Bieschke J, Dendle MA, Kelly JW. Amide-to-E-olefin versus amide-to-ester backbone H-bond perturbations: Evaluating the O-O repulsion for extracting H-bond energies. Journal of the American Chemical Society. 128: 15948-9. PMID 17165703 DOI: 10.1021/ja065303t  1
2006 Sawkar AR, Schmitz M, Zimmer KP, Reczek D, Edmunds T, Balch WE, Kelly JW. Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants. Acs Chemical Biology. 1: 235-51. PMID 17163678 DOI: 10.1021/cb600187q  1
2006 Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, Noel JP. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Molecular Cell. 24: 759-70. PMID 17157258 DOI: 10.1016/j.molcel.2006.10.027  1
2006 Wang X, Venable J, LaPointe P, Hutt DM, Koulov AV, Coppinger J, Gurkan C, Kellner W, Matteson J, Plutner H, Riordan JR, Kelly JW, Yates JR, Balch WE. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell. 127: 803-15. PMID 17110338 DOI: 10.1016/j.cell.2006.09.043  1
2006 Sekijima Y, Dendle MA, Kelly JW. Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13: 236-49. PMID 17107884 DOI: 10.1080/13506120600960882  1
2006 Tojo K, Sekijima Y, Kelly JW, Ikeda S. Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis. Neuroscience Research. 56: 441-9. PMID 17028027 DOI: 10.1016/j.neures.2006.08.014  1
2006 Bieschke J, Zhang Q, Bosco DA, Lerner RA, Powers ET, Wentworth P, Kelly JW. Small molecule oxidation products trigger disease-associated protein misfolding. Accounts of Chemical Research. 39: 611-9. PMID 16981677 DOI: 10.1021/ar0500766  1
2006 Sekijima Y, Dendle MT, Wiseman RL, White JT, D'Haeze W, Kelly JW. R104H may suppress transthyretin amyloidogenesis by thermodynamic stabilization, but not by the kinetic mechanism characterizing T119 interallelic trans-suppression. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13: 57-66. PMID 16911959 DOI: 10.1080/13506120600722449  1
2006 Reixach N, Adamski-Werner SL, Kelly JW, Koziol J, Buxbaum JN. Cell based screening of inhibitors of transthyretin aggregation. Biochemical and Biophysical Research Communications. 348: 889-97. PMID 16904635 DOI: 10.1016/j.bbrc.2006.07.109  0.88
2006 Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science (New York, N.Y.). 313: 1604-10. PMID 16902091 DOI: 10.1126/science.1124646  1
2006 Jäger M, Zhang Y, Bieschke J, Nguyen H, Dendle M, Bowman ME, Noel JP, Gruebele M, Kelly JW. Structure-function-folding relationship in a WW domain. Proceedings of the National Academy of Sciences of the United States of America. 103: 10648-53. PMID 16807295 DOI: 10.1073/pnas.0600511103  1
2006 Cordeiro Y, Kraineva J, Suarez MC, Tempesta AG, Kelly JW, Silva JL, Winter R, Foguel D. Fourier transform infrared spectroscopy provides a fingerprint for the tetramer and for the aggregates of transthyretin. Biophysical Journal. 91: 957-67. PMID 16698785 DOI: 10.1529/biophysj.106.085928  1
2006 Kelly JW, Balch WE. The integration of cell and chemical biology in protein folding. Nature Chemical Biology. 2: 224-7. PMID 16619016 DOI: 10.1038/nchembio0506-224  1
2006 Sawkar AR, D'Haeze W, Kelly JW. Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease. Cellular and Molecular Life Sciences : Cmls. 63: 1179-92. PMID 16568247 DOI: 10.1007/s00018-005-5437-0  1
2006 Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nature Chemical Biology. 2: 249-53. PMID 16565714 DOI: 10.1038/nchembio782  1
2006 Suk JY, Zhang F, Balch WE, Linhardt RJ, Kelly JW. Heparin accelerates gelsolin amyloidogenesis. Biochemistry. 45: 2234-42. PMID 16475811 DOI: 10.1021/bi0519295  1
2006 Deechongkit S, Nguyen H, Jager M, Powers ET, Gruebele M, Kelly JW. Beta-sheet folding mechanisms from perturbation energetics. Current Opinion in Structural Biology. 16: 94-101. PMID 16442278 DOI: 10.1016/j.sbi.2006.01.014  1
2006 Fowler DM, Koulov AV, Alory-Jost C, Marks MS, Balch WE, Kelly JW. Functional amyloid formation within mammalian tissue. Plos Biology. 4: e6. PMID 16300414 DOI: 10.1371/journal.pbio.0040006  1
2005 Nguyen H, Jäger M, Kelly JW, Gruebele M. Engineering a beta-sheet protein toward the folding speed limit. The Journal of Physical Chemistry. B. 109: 15182-6. PMID 16852923 DOI: 10.1021/jp052373y  1
2005 Powers ET, Deechongkit S, Kelly JW. Backbone-Backbone H-Bonds Make Context-Dependent Contributions to Protein Folding Kinetics and Thermodynamics: Lessons from Amide-to-Ester Mutations. Advances in Protein Chemistry. 72: 39-78. PMID 16581372 DOI: 10.1016/S0065-3233(05)72002-7  1
2005 Johnson SM, Wiseman RL, Sekijima Y, Green NS, Adamski-Werner SL, Kelly JW. Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses. Accounts of Chemical Research. 38: 911-21. PMID 16359163 DOI: 10.1021/ar020073i  1
2005 Wiseman RL, Powers ET, Kelly JW. Partitioning conformational intermediates between competing refolding and aggregation pathways: insights into transthyretin amyloid disease. Biochemistry. 44: 16612-23. PMID 16342952 DOI: 10.1021/bi0511484  1
2005 Foss TR, Wiseman RL, Kelly JW. The pathway by which the tetrameric protein transthyretin dissociates. Biochemistry. 44: 15525-33. PMID 16300401 DOI: 10.1021/bi051608t  1
2005 Sawkar AR, Adamski-Werner SL, Cheng WC, Wong CH, Beutler E, Zimmer KP, Kelly JW. Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles. Chemistry & Biology. 12: 1235-44. PMID 16298303 DOI: 10.1016/j.chembiol.2005.09.007  1
2005 Page LJ, Suk JY, Huff ME, Lim HJ, Venable J, Yates J, Kelly JW, Balch WE. Metalloendoprotease cleavage triggers gelsolin amyloidogenesis. The Embo Journal. 24: 4124-32. PMID 16281052 DOI: 10.1038/sj.emboj.7600872  1
2005 Fu Y, Bieschke J, Kelly JW. E-olefin dipeptide isostere incorporation into a polypeptide backbone enables hydrogen bond perturbation: probing the requirements for Alzheimer's amyloidogenesis. Journal of the American Chemical Society. 127: 15366-7. PMID 16262389 DOI: 10.1021/ja0551382  1
2005 Green NS, Foss TR, Kelly JW. Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 14545-50. PMID 16195386 DOI: 10.1073/pnas.0501609102  1
2005 Frankenfield KN, Powers ET, Kelly JW. Influence of the N-terminal domain on the aggregation properties of the prion protein. Protein Science : a Publication of the Protein Society. 14: 2154-66. PMID 16046631 DOI: 10.1110/ps.051434005  1
2005 Wiseman RL, Green NS, Kelly JW. Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis. Biochemistry. 44: 9265-74. PMID 15966751 DOI: 10.1021/bi050352o  1
2005 Zhang Q, Kelly JW. Cys-10 mixed disulfide modifications exacerbate transthyretin familial variant amyloidogenicity: a likely explanation for variable clinical expression of amyloidosis and the lack of pathology in C10S/V30M transgenic mice? Biochemistry. 44: 9079-85. PMID 15966731 DOI: 10.1021/bi050378f  1
2005 Deechongkit S, Powers ET, You SL, Kelly JW. Controlling the morphology of cross beta-sheet assemblies by rational design. Journal of the American Chemical Society. 127: 8562-70. PMID 15941292 DOI: 10.1021/ja050558c  1
2005 Petrassi HM, Johnson SM, Purkey HE, Chiang KP, Walkup T, Jiang X, Powers ET, Kelly JW. Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state. Journal of the American Chemical Society. 127: 6662-71. PMID 15869287 DOI: 10.1021/ja044351f  1
2005 Wiseman RL, Johnson SM, Kelker MS, Foss T, Wilson IA, Kelly JW. Kinetic stabilization of an oligomeric protein by a single ligand binding event. Journal of the American Chemical Society. 127: 5540-51. PMID 15826192 DOI: 10.1021/ja042929f  1
2005 Sekijima Y, Wiseman RL, Matteson J, Hammarström P, Miller SR, Sawkar AR, Balch WE, Kelly JW. The biological and chemical basis for tissue-selective amyloid disease. Cell. 121: 73-85. PMID 15820680 DOI: 10.1016/j.cell.2005.01.018  1
2005 Premkumar L, Sawkar AR, Boldin-Adamsky S, Toker L, Silman I, Kelly JW, Futerman AH, Sussman JL. X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. The Journal of Biological Chemistry. 280: 23815-9. PMID 15817452 DOI: 10.1074/jbc.M502799200  1
2005 Bieschke J, Zhang Q, Powers ET, Lerner RA, Kelly JW. Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation. Biochemistry. 44: 4977-83. PMID 15794636 DOI: 10.1021/bi0501030  1
2005 Foss TR, Kelker MS, Wiseman RL, Wilson IA, Kelly JW. Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis. Journal of Molecular Biology. 347: 841-54. PMID 15769474 DOI: 10.1016/j.jmb.2005.01.050  1
2005 Johnson SM, Petrassi HM, Palaninathan SK, Mohamedmohaideen NN, Purkey HE, Nichols C, Chiang KP, Walkup T, Sacchettini JC, Sharpless KB, Kelly JW. Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation. Journal of Medicinal Chemistry. 48: 1576-87. PMID 15743199 DOI: 10.1021/jm049274d  1
2005 Razavi H, Powers ET, Purkey HE, Adamski-Werner SL, Chiang KP, Dendle MT, Kelly JW. Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 1075-8. PMID 15686915 DOI: 10.1016/j.bmcl.2004.12.022  1
2004 Deechongkit S, Dawson PE, Kelly JW. Toward assessing the position-dependent contributions of backbone hydrogen bonding to beta-sheet folding thermodynamics employing amide-to-ester perturbations. Journal of the American Chemical Society. 126: 16762-71. PMID 15612714 DOI: 10.1021/ja045934s  1
2004 Purkey HE, Palaninathan SK, Kent KC, Smith C, Safe SH, Sacchettini JC, Kelly JW. Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity. Chemistry & Biology. 11: 1719-28. PMID 15610856 DOI: 10.1016/j.chembiol.2004.10.009  1
2004 Page LJ, Huff ME, Kelly JW, Balch WE. Ca2+ binding protects against gelsolin amyloidosis. Biochemical and Biophysical Research Communications. 322: 1105-10. PMID 15336957 DOI: 10.1016/j.bbrc.2004.07.125  1
2004 You SL, Deechongkit S, Kelly JW. Solid-phase synthesis and stereochemical assignments of tenuecyclamides A-D employing heterocyclic amino acids derived from commercially available Fmoc alpha-amino acids. Organic Letters. 6: 2627-30. PMID 15255707 DOI: 10.1021/ol049020m  1
2004 Deechongkit S, Nguyen H, Powers ET, Dawson PE, Gruebele M, Kelly JW. Context-dependent contributions of backbone hydrogen bonding to beta-sheet folding energetics. Nature. 430: 101-5. PMID 15229605 DOI: 10.1038/nature02611  1
2004 Hurshman AR, White JT, Powers ET, Kelly JW. Transthyretin aggregation under partially denaturing conditions is a downhill polymerization. Biochemistry. 43: 7365-81. PMID 15182180 DOI: 10.1021/bi049621l  1
2004 You SL, Kelly JW. Highly efficient enantiospecific synthesis of imidazoline-containing amino acids using bis(triphenyl)oxodiphosphonium trifluoromethanesulfonate. Organic Letters. 6: 1681-3. PMID 15128266 DOI: 10.1021/ol049439c  1
2004 Zhang Q, Powers ET, Nieva J, Huff ME, Dendle MA, Bieschke J, Glabe CG, Eschenmoser A, Wentworth P, Lerner RA, Kelly JW. Metabolite-initiated protein misfolding may trigger Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 4752-7. PMID 15034169 DOI: 10.1073/pnas.0400924101  1
2004 Reixach N, Deechongkit S, Jiang X, Kelly JW, Buxbaum JN. Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture. Proceedings of the National Academy of Sciences of the United States of America. 101: 2817-22. PMID 14981241 DOI: 10.1073/pnas.0400062101  1
2004 Miller SR, Sekijima Y, Kelly JW. Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants. Laboratory Investigation; a Journal of Technical Methods and Pathology. 84: 545-52. PMID 14968122 DOI: 10.1038/labinvest.3700059  1
2004 Deechongkit S, You SL, Kelly JW. Synthesis of all nineteen appropriately protected chiral alpha-hydroxy acid equivalents of the alpha-amino acids for Boc solid-phase depsi-peptide synthesis. Organic Letters. 6: 497-500. PMID 14961607 DOI: 10.1021/ol036102m  1
2004 Adamski-Werner SL, Palaninathan SK, Sacchettini JC, Kelly JW. Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. Journal of Medicinal Chemistry. 47: 355-74. PMID 14711308 DOI: 10.1021/jm030347n  0.88
2004 You SL, Kelly JW. Highly efficient biomimetic total synthesis and structural verification of bistratamides E and J from Lissoclinum bistratum. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 71-5. PMID 14695551 DOI: 10.1002/chem.200305504  1
2003 You SL, Razavi H, Kelly JW. A biomimetic synthesis of thiazolines using hexaphenyloxodiphosphonium trifluoromethanesulfonate. Angewandte Chemie (International Ed. in English). 42: 83-5. PMID 19757597 DOI: 10.1002/anie.200390059  1
2003 Kustedjo K, Deechongkit S, Kelly JW, Cravatt BF. Recombinant expression, purification, and comparative characterization of torsinA and its torsion dystonia-associated variant Delta E-torsinA. Biochemistry. 42: 15333-41. PMID 14690443 DOI: 10.1021/bi0349569  1
2003 Cohen FE, Kelly JW. Therapeutic approaches to protein-misfolding diseases. Nature. 426: 905-9. PMID 14685252 DOI: 10.1038/nature02265  1
2003 Huff ME, Balch WE, Kelly JW. Pathological and functional amyloid formation orchestrated by the secretory pathway. Current Opinion in Structural Biology. 13: 674-82. PMID 14675544 DOI: 10.1016/j.sbi.2003.10.010  1
2003 You SL, Kelly JW. Total synthesis of dendroamide a: oxazole and thiazole construction using an oxodiphosphonium salt. The Journal of Organic Chemistry. 68: 9506-9. PMID 14629183 DOI: 10.1021/jo0302657  1
2003 Huff ME, Page LJ, Balch WE, Kelly JW. Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin proteolysis and familial amyloidosis of finnish type. Journal of Molecular Biology. 334: 119-27. PMID 14596804 DOI: 10.1016/j.jmb.2003.09.029  1
2003 Green NS, Palaninathan SK, Sacchettini JC, Kelly JW. Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization. Journal of the American Chemical Society. 125: 13404-14. PMID 14583036 DOI: 10.1021/ja030294z  1
2003 DiDonato M, Craig L, Huff ME, Thayer MM, Cardoso RM, Kassmann CJ, Lo TP, Bruns CK, Powers ET, Kelly JW, Getzoff ED, Tainer JA. ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization. Journal of Molecular Biology. 332: 601-15. PMID 12963370 DOI: 10.1016/S0022-2836(03)00889-1  1
2003 Foguel D, Suarez MC, Ferrão-Gonzales AD, Porto TC, Palmieri L, Einsiedler CM, Andrade LR, Lashuel HA, Lansbury PT, Kelly JW, Silva JL. Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities. Proceedings of the National Academy of Sciences of the United States of America. 100: 9831-6. PMID 12900507 DOI: 10.1073/pnas.1734009100  1
2003 Zhang Q, Kelly JW. Cys10 mixed disulfides make transthyretin more amyloidogenic under mildly acidic conditions. Biochemistry. 42: 8756-61. PMID 12873136 DOI: 10.1021/bi030077a  1
2003 Calarese DA, Scanlan CN, Zwick MB, Deechongkit S, Mimura Y, Kunert R, Zhu P, Wormald MR, Stanfield RL, Roux KH, Kelly JW, Rudd PM, Dwek RA, Katinger H, Burton DR, et al. Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science (New York, N.Y.). 300: 2065-71. PMID 12829775 DOI: 10.1126/science.1083182  1
2003 Razavi H, Palaninathan SK, Powers ET, Wiseman RL, Purkey HE, Mohamedmohaideen NN, Deechongkit S, Chiang KP, Dendle MT, Sacchettini JC, Kelly JW. Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action. Angewandte Chemie (International Ed. in English). 42: 2758-61. PMID 12820260 DOI: 10.1002/anie.200351179  1
2003 Hammarström P, Sekijima Y, White JT, Wiseman RL, Lim A, Costello CE, Altland K, Garzuly F, Budka H, Kelly JW. D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis? Biochemistry. 42: 6656-63. PMID 12779320 DOI: 10.1021/bi027319b  1
2003 Kelly JW, Balch WE. Amyloid as a natural product. The Journal of Cell Biology. 161: 461-2. PMID 12743097 DOI: 10.1083/jcb.200304074  1
2003 Ferrão-Gonzales AD, Palmieri L, Valory M, Silva JL, Lashuel H, Kelly JW, Foguel D. Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease. Journal of Molecular Biology. 328: 963-74. PMID 12729768 DOI: 10.1016/S0022-2836(03)00368-1  0.6
2003 Lu JR, Perumal S, Powers ET, Kelly JW, Webster JR, Penfold J. Adsorption of beta-hairpin peptides on the surface of water: a neutron reflection study. Journal of the American Chemical Society. 125: 3751-7. PMID 12656605 DOI: 10.1021/ja0292290  1
2003 Nguyen H, Jager M, Moretto A, Gruebele M, Kelly JW. Tuning the free-energy landscape of a WW domain by temperature, mutation, and truncation. Proceedings of the National Academy of Sciences of the United States of America. 100: 3948-53. PMID 12651955 DOI: 10.1073/pnas.0538054100  1
2003 Sekijima Y, Hammarström P, Matsumura M, Shimizu Y, Iwata M, Tokuda T, Ikeda S, Kelly JW. Energetic characteristics of the new transthyretin variant A25T may explain its atypical central nervous system pathology. Laboratory Investigation; a Journal of Technical Methods and Pathology. 83: 409-17. PMID 12649341  1
2003 Hammarström P, Wiseman RL, Powers ET, Kelly JW. Prevention of transthyretin amyloid disease by changing protein misfolding energetics. Science (New York, N.Y.). 299: 713-6. PMID 12560553 DOI: 10.1126/science.1079589  1
2002 Powers ET, Yang SI, Lieber CM, Kelly JW. Ordered Langmuir-Blodgett films of amphiphilic beta-hairpin peptides imaged by atomic force microscopy. Angewandte Chemie (International Ed. in English). 41: 127-30. PMID 12491460 DOI: 10.1002/1521-3757(20020104)114:1<135::AID-ANGE135>3.0.CO;2-1  1
2002 Sawkar AR, Cheng WC, Beutler E, Wong CH, Balch WE, Kelly JW. Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 15428-33. PMID 12434014 DOI: 10.1073/pnas.192582899  1
2002 Kaul R, Deechongkit S, Kelly JW. Synthesis of a negatively charged dibenzofuran-based beta-turn mimetic and its incorporation into the WW miniprotein-enhanced solubility without a loss of thermodynamic stability. Journal of the American Chemical Society. 124: 11900-7. PMID 12358534 DOI: 10.1021/ja020675x  1
2002 Hammarström P, Jiang X, Hurshman AR, Powers ET, Kelly JW. Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity. Proceedings of the National Academy of Sciences of the United States of America. 99: 16427-32. PMID 12351683 DOI: 10.1073/pnas.202495199  1
2002 Sacchettini JC, Kelly JW. Therapeutic strategies for human amyloid diseases. Nature Reviews. Drug Discovery. 1: 267-75. PMID 12120278 DOI: 10.1038/nrd769  0.52
2002 Liu K, Kelly JW, Wemmer DE. Native state hydrogen exchange study of suppressor and pathogenic variants of transthyretin. Journal of Molecular Biology. 320: 821-32. PMID 12095258 DOI: 10.1016/S0022-2836(02)00471-0  1
2002 McCammon MG, Scott DJ, Keetch CA, Greene LH, Purkey HE, Petrassi HM, Kelly JW, Robinson CV. Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry. Structure (London, England : 1993). 10: 851-63. PMID 12057199 DOI: 10.1016/S0969-2126(02)00771-2  1
2002 Deechongkit S, Kelly JW. The effect of backbone cyclization on the thermodynamics of beta-sheet unfolding: stability optimization of the PIN WW domain. Journal of the American Chemical Society. 124: 4980-6. PMID 11982361 DOI: 10.1021/ja0123608  1
2002 Kowalski JA, Liu K, Kelly JW. NMR solution structure of the isolated Apo Pin1 WW domain: comparison to the x-ray crystal structures of Pin1. Biopolymers. 63: 111-21. PMID 11786999 DOI: 10.1002/bip.10020  0.48
2002 Oza VB, Smith C, Raman P, Koepf EK, Lashuel HA, Petrassi HM, Chiang KP, Powers ET, Sachettinni J, Kelly JW. Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors. Journal of Medicinal Chemistry. 45: 321-32. PMID 11784137 DOI: 10.1021/jm010257n  1
2001 Chen CD, Huff ME, Matteson J, Page L, Phillips R, Kelly JW, Balch WE. Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization. The Embo Journal. 20: 6277-87. PMID 11707399 DOI: 10.1093/emboj/20.22.6277  1
2001 White JT, Kelly JW. Support for the multigenic hypothesis of amyloidosis: the binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity in vitro. Proceedings of the National Academy of Sciences of the United States of America. 98: 13019-24. PMID 11687657 DOI: 10.1073/pnas.241406698  1
2001 Hammarström P, Jiang X, Deechongkit S, Kelly JW. Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: insight into the chaotrope unfolding dichotomy. Biochemistry. 40: 11453-9. PMID 11560493 DOI: 10.1021/bi010673+  1
2001 Jiang X, Smith CS, Petrassi HM, Hammarström P, White JT, Sacchettini JC, Kelly JW. An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured. Biochemistry. 40: 11442-52. PMID 11560492 DOI: 10.1021/bi011194d  1
2001 Petrassi HM, Sharpless KB, Kelly JW. The copper-mediated cross-coupling of phenylboronic acids and N-hydroxyphthalimide at room temperature: synthesis of aryloxyamines. Organic Letters. 3: 139-42. PMID 11429858 DOI: 10.1021/ol0003533  1
2001 Purkey HE, Dorrell MI, Kelly JW. Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma. Proceedings of the National Academy of Sciences of the United States of America. 98: 5566-71. PMID 11344299 DOI: 10.1073/pnas.091431798  1
2001 Ratnaswamy G, Huff ME, Su AI, Rion S, Kelly JW. Destabilization of Ca2+-free gelsolin may not be responsible for proteolysis in Familial Amyloidosis of Finnish Type. Proceedings of the National Academy of Sciences of the United States of America. 98: 2334-9. PMID 11226240 DOI: 10.1073/pnas.041452598  1
2000 Lashuel HA, Labrenz SR, Woo L, Serpell LC, Kelly JW. Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly:  implications for amyloid fibril formation and materials science. Journal of the American Chemical Society. 122: 5262-77. PMID 22339465 DOI: 10.1021/ja9937831  1
2000 Liu K, Cho HS, Lashuel HA, Kelly JW, Wemmer DE. A glimpse of a possible amyloidogenic intermediate of transthyretin. Nature Structural Biology. 7: 754-7. PMID 10966644 DOI: 10.1038/78980  1
2000 Klabunde T, Petrassi HM, Oza VB, Raman P, Kelly JW, Sacchettini JC. Rational design of potent human transthyretin amyloid disease inhibitors. Nature Structural Biology. 7: 312-21. PMID 10742177 DOI: 10.1038/74082  1
1999 Koepf EK, Petrassi HM, Ratnaswamy G, Huff ME, Sudol M, Kelly JW. Characterization of the structure and function of W --> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding. Biochemistry. 38: 14338-51. PMID 10572009 DOI: 10.1021/bi991105l  1
1999 Lashuel HA, Wurth C, Woo L, Kelly JW. The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions. Biochemistry. 38: 13560-73. PMID 10521263 DOI: 10.1021/bi991021c  1
1999 Baures PW, Oza VB, Peterson SA, Kelly JW. Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid. Bioorganic & Medicinal Chemistry. 7: 1339-47. PMID 10465408 DOI: 10.1016/S0968-0896(99)00066-8  1
1999 Koepf EK, Petrassi HM, Sudol M, Kelly JW. WW: An isolated three-stranded antiparallel beta-sheet domain that unfolds and refolds reversibly; evidence for a structured hydrophobic cluster in urea and GdnHCl and a disordered thermal unfolded state. Protein Science : a Publication of the Protein Society. 8: 841-53. PMID 10211830 DOI: 10.1110/ps.8.4.841  1
1999 Chitnumsub P, Fiori WR, Lashuel HA, Diaz H, Kelly JW. The nucleation of monomeric parallel beta-sheet-like structures and their self-assembly in aqueous solution. Bioorganic & Medicinal Chemistry. 7: 39-59. PMID 10199655 DOI: 10.1016/S0968-0896(98)00222-3  1
1999 Oza VB, Petrassi HM, Purkey HE, Kelly JW. Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors. Bioorganic & Medicinal Chemistry Letters. 9: 1-6. PMID 9990446 DOI: 10.1016/S0960-894X(98)00696-9  1
1998 Lashuel HA, Lai Z, Kelly JW. Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation. Biochemistry. 37: 17851-64. PMID 9922152 DOI: 10.1021/bi981876+  1
1998 Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF. Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization. Biochemistry. 37: 15177-87. PMID 9790682 DOI: 10.1021/bi981733n  1
1998 Peterson SA, Klabunde T, Lashuel HA, Purkey H, Sacchettini JC, Kelly JW. Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. Proceedings of the National Academy of Sciences of the United States of America. 95: 12956-60. PMID 9789022 DOI: 10.1073/pnas.95.22.12956  1
1998 Baures PW, Peterson SA, Kelly JW. Discovering transthyretin amyloid fibril inhibitors by limited screening. Bioorganic & Medicinal Chemistry. 6: 1389-401. PMID 9784876 DOI: 10.1016/S0968-0896(98)00130-8  1
1998 Xie Y, Lashuel HA, Miroy GJ, Dikler S, Kelly JW. Recombinant human retinol-binding protein refolding, native disulfide formation, and characterization. Protein Expression and Purification. 14: 31-7. PMID 9758748 DOI: 10.1006/prep.1998.0944  1
1997 Kelly JW, Colon W, Lai Z, Lashuel HA, McCulloch J, McCutchen SL, Miroy GJ, Peterson SA. Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid. Advances in Protein Chemistry. 50: 161-81. PMID 9338081  0.88
1997 Lai Z, McCulloch J, Lashuel HA, Kelly JW. Guanidine hydrochloride-induced denaturation and refolding of transthyretin exhibits a marked hysteresis: equilibria with high kinetic barriers. Biochemistry. 36: 10230-9. PMID 9254621 DOI: 10.1021/bi963195p  0.88
1996 Miroy GJ, Lai Z, Lashuel HA, Peterson SA, Strang C, Kelly JW. Inhibiting transthyretin amyloid fibril formation via protein stabilization. Proceedings of the National Academy of Sciences of the United States of America. 93: 15051-6. PMID 8986762 DOI: 10.1073/pnas.93.26.15051  0.88
1996 Colon W, Lai Z, McCutchen SL, Miroy GJ, Strang C, Kelly JW. FAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formation. Ciba Foundation Symposium. 199: 228-38; discussion 2. PMID 8915613  0.88
1996 Lai Z, Colón W, Kelly JW. The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid. Biochemistry. 35: 6470-82. PMID 8639594 DOI: 10.1021/bi952501g  0.88
1995 McCutchen SL, Lai Z, Miroy GJ, Kelly JW, Colón W. Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease. Biochemistry. 34: 13527-36. PMID 7577941 DOI: 10.1021/bi00041a032  0.68
1993 McCutchen SL, Colon W, Kelly JW. Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity. Biochemistry. 32: 12119-27. PMID 8218290  0.88
1992 Colon W, Kelly JW. Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro. Biochemistry. 31: 8654-60. PMID 1390650  0.88
1989 Kaiser ET, Mihara H, Laforet GA, Kelly JW, Walters L, Findeis MA, Sasaki T. Peptide and protein synthesis by segment synthesis-condensation. Science (New York, N.Y.). 243: 187-92. PMID 2492114  0.88
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