Donald P. McDonnell - Publications

Duke University, Durham, NC 
Pharmacology, Biochemistry, Molecular Biology

265 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Artham S, Chang CY, McDonnell DP. Eosinophilia in cancer and its regulation by sex hormones. Trends in Endocrinology and Metabolism: Tem. 34: 5-20. PMID 36443206 DOI: 10.1016/j.tem.2022.11.002  0.346
2022 Tsuji J, Li T, Grinshpun A, Coorens T, Russo D, Anderson L, Rees R, Nardone A, Patterson C, Lennon NJ, Cibulskis C, Leshchiner I, Tayob N, Tolaney SM, Tung N, ... McDonnell DP, et al. Clinical Efficacy and Whole Exome Sequencing of Liquid Biopsies in a Phase IB/II study of Bazedoxifene and Palbociclib in Hormone Receptor-Positive Breast Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 36215125 DOI: 10.1158/1078-0432.CCR-22-2305  0.515
2022 Sammeta VR, Norris JD, Artham S, Torrice CD, Byemerwa J, Joiner C, Fanning SW, McDonnell DP, Willson TM. A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3-]pyrimidine Core. Acs Medicinal Chemistry Letters. 13: 1151-1158. PMID 35859859 DOI: 10.1021/acsmedchemlett.2c00180  0.404
2022 Chakraborty B, Byemerwa J, Krebs T, Lim F, Chang CY, McDonnell DP. Estrogen receptor signaling in the immune system. Endocrine Reviews. PMID 35709009 DOI: 10.1210/endrev/bnac017  0.314
2021 Haines CN, Wardell SE, McDonnell DP. Current and emerging estrogen receptor-targeted therapies for the treatment of breast cancer. Essays in Biochemistry. PMID 34328178 DOI: 10.1042/EBC20200174  0.422
2020 Andreano KJ, Baker JG, Park S, Safi R, Artham S, Oesterreich S, Jeselsohn R, Brown M, Sammons S, Wardell SE, Chang CY, Norris JD, McDonnell DP. The dysregulated pharmacology of clinically relevant ESR1 mutants is normalized by ligand-activated WT receptor. Molecular Cancer Therapeutics. PMID 32381587 DOI: 10.1158/1535-7163.Mct-19-1148  0.518
2020 Chakraborty B, Bymerwa J, Baldi R, Liu W, Chang C, McDonnell D. Abstract A44: Pharmacologic targeting of estrogen receptor in melanoma to enhance antitumor immunity Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm19-A44  0.356
2019 Cocce KJ, Jasper JS, Desautels TK, Everett L, Wardell S, Westerling T, Baldi R, Wright TM, Tavares K, Yllanes A, Bae Y, Blitzer JT, Logsdon C, Rakiec DP, Ruddy DA, ... ... McDonnell DP, et al. The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer. Cell Reports. 29: 889-903.e10. PMID 31644911 DOI: 10.1016/J.Celrep.2019.09.032  0.4
2019 Wardell SE, Yllanes AP, Chao CA, Bae Y, Andreano KJ, Desautels TK, Heetderks KA, Blitzer JT, Norris JD, McDonnell DP. Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy. Breast Cancer Research and Treatment. PMID 31562570 DOI: 10.1007/S10549-019-05454-Y  0.461
2019 Park S, Safi R, Liu X, Baldi R, Liu W, Liu J, Locasale JW, Chang CY, McDonnell DP. Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. Cell Reports. 27: 3587-3601.e4. PMID 31216477 DOI: 10.1016/J.Celrep.2019.05.066  0.363
2019 Racioppi L, Nelson ER, Huang W, Mukherjee D, Lawrence SA, Lento W, Masci AM, Jiao Y, Park S, York B, Liu Y, Baek AE, Drewry DH, Zuercher WJ, Bertani FR, ... ... McDonnell DP, et al. CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. Nature Communications. 10: 2450. PMID 31164648 DOI: 10.1038/S41467-019-10424-5  0.318
2019 Gaillard SL, Andreano KJ, Gay LM, Steiner M, Jorgensen MS, Davidson BA, Havrilesky LJ, Alvarez Secord A, Valea FA, Colon-Otero G, Zajchowski DA, Chang CY, McDonnell DP, Berchuck A, Elvin JA. Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies. Gynecologic Oncology. PMID 30987772 DOI: 10.1016/J.Ygyno.2019.04.010  0.432
2019 Wardell SE, Norris JD, McDonnell DP. Targeting mutant estrogen receptors. Elife. 8. PMID 30648967 DOI: 10.7554/Elife.44181  0.492
2019 McDonnell DP. The Molecular Pharmacology of SERMs. Trends in Endocrinology and Metabolism: Tem. 10: 301-311. PMID 10481160 DOI: 10.1016/S1043-2760(99)00177-0  0.503
2019 McDonnell DP, Safi R. 1H. Liver X receptor-like receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f89/2019.4  0.383
2019 Sammons S, Anderson G, Wardell S, McDonnell DP, Marcom PK, Wood K. Combination mTORC1/2 and BCL- XL inhibition in endocrine and CDK4/6-resistant estrogen receptor-positive breast cancer. Journal of Clinical Oncology. 37: e14653-e14653. DOI: 10.1200/Jco.2019.37.15_Suppl.E14653  0.371
2018 Johng D, Torga G, Ewing CM, Jin K, Norris JD, McDonnell DP, Isaacs WB. HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer. The Prostate. PMID 30560549 DOI: 10.1002/Pros.23747  0.32
2018 Salami J, Alabi S, Willard RR, Vitale NJ, Wang J, Dong H, Jin M, McDonnell DP, Crew AP, Neklesa TK, Crews CM. Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Communications Biology. 1: 100. PMID 30271980 DOI: 10.1038/s42003-018-0105-8  0.338
2018 Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Giguère V, Bay BH, Vanacker JM, Ghosh S, ... ... McDonnell DP, et al. Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function. Science Signaling. 11. PMID 29945885 DOI: 10.1126/Scisignal.Aam5855  0.374
2018 Tria GS, Abrams T, Baird J, Burks HE, Firestone B, Gaither LA, Hamann LG, He G, Kirby CA, Kim S, Lombardo F, Macchi KJ, McDonnell DP, Mishina Y, Norris JD, et al. Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer. Journal of Medicinal Chemistry. PMID 29562737 DOI: 10.1021/Acs.Jmedchem.7B01682  0.502
2018 McDonnell DP, Norris JD, Chang CY. Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery. Cancer Cell. 33: 153-155. PMID 29438688 DOI: 10.1016/J.Ccell.2018.01.014  0.404
2018 Gaillard S, Gay LM, Steiner M, Andreano K, Davidson BA, Havrilesky LJ, Secord AA, Valea FA, Colon-Otero G, Zajchowski DA, Chang C, McDonnell DP, Berchuck A, Elvin JA. Assessment of activating estrogen receptor 1 (ESR1) mutations in gynecologic malignancies. Journal of Clinical Oncology. 36: 5590-5590. DOI: 10.1200/Jco.2018.36.15_Suppl.5590  0.401
2018 Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov A, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, ... McDonnell DP, et al. Abstract 5496: A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product Cancer Research. 78: 5496-5496. DOI: 10.1158/1538-7445.Am2018-5496  0.342
2018 Yao Z, Wardell S, Spasojevic I, Norris J, Katzenellenbogen J, McDonnell D, Josan JS. Abstract 1805: Development of a selective androgen receptor degrader (SARD) for treatment of castration-resistant prostate cancer Cancer Research. 78: 1805-1805. DOI: 10.1158/1538-7445.Am2018-1805  0.438
2017 McLeod AB, Stice JP, Wardell SE, Alley HM, Chang CY, McDonnell DP. Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer. The Prostate. PMID 29243324 DOI: 10.1002/Pros.23467  0.361
2017 Baek AE, Yu YA, He S, Wardell SE, Chang CY, Kwon S, Pillai RV, McDowell HB, Thompson JW, Dubois LG, Sullivan PM, Kemper JK, Gunn MD, McDonnell DP, Nelson ER. The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. Nature Communications. 8: 864. PMID 29021522 DOI: 10.1038/S41467-017-00910-Z  0.332
2017 Coons LA, Hewitt SC, Burkholder AB, McDonnell DP, Korach KS. DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin. Endocrinology. 158: 3212-3234. PMID 28977594 DOI: 10.1210/En.2017-00468  0.386
2017 Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, ... McDonnell DP, et al. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metabolism. PMID 28918937 DOI: 10.1016/J.Cmet.2017.08.017  0.319
2017 Norris JD, Ellison SJ, Baker JG, Stagg DB, Wardell SE, Park S, Alley HM, Baldi RM, Yllanes A, Andreano KJ, Stice JP, Lawrence SA, Eisner JR, Price DK, Moore WR, ... ... McDonnell DP, et al. Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer. The Journal of Clinical Investigation. PMID 28463227 DOI: 10.1172/Jci87328  0.398
2017 Kimbung S, Chang C, Bendahl PO, Dubois L, Thompson WJ, McDonnell DP, Borgquist S. Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer. Endocrine-Related Cancer. PMID 28442559 DOI: 10.1530/Erc-16-0533  0.388
2017 Burks HE, Abrams T, Kirby CA, Baird J, Fekete A, Hamann LG, Kim S, Lombardo F, Loo A, Lubicka D, Macchi K, McDonnell DP, Mishina Y, Norris JD, Nunez J, et al. Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer. Journal of Medicinal Chemistry. PMID 28296398 DOI: 10.1021/Acs.Jmedchem.6B01468  0.482
2017 Stice JP, Wardell SE, Norris JD, Yllanes AP, Alley HM, Haney VO, White HS, Safi R, Winter PS, Cocce KJ, Kishton RJ, Lawrence SA, Strum JC, McDonnell DP. CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC. Molecular Cancer Research : McR. PMID 28209757 DOI: 10.1158/1541-7786.Mcr-17-0028  0.38
2017 Christenson JL, Butterfield KT, Spoelstra NS, Norris JD, Josan JS, Pollock JA, McDonnell DP, Katzenellenbogen BS, Katzenellenbogen JA, Richer JK. MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression. Hormones & Cancer. PMID 28194662 DOI: 10.1007/S12672-017-0285-6  0.433
2017 Alfaqih MA, Nelson ER, Liu W, Safi R, Jasper JS, Macias E, Geradts J, Dubois LG, Thompson W, Freeman MR, Chang CY, Chi JT, McDonnell DP, Freedland SJ. CYP27A1 loss dysregulates cholesterol homeostasis in prostate cancer. Cancer Research. PMID 28130224 DOI: 10.1158/0008-5472.Can-16-2738  0.359
2017 McDonnell D, Cocce K, Wardell S, Norris J. Abstract IA30: Targeting hormone receptors for degradation: Nuclear receptor downregulation as a therapeutic approach in cancer Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-Ia30  0.524
2017 Quayle L, Park S, McDonnell D, Ottewell P, Holen I. Abstract P3-07-14: Targeting ERR-α regulated lactate metabolism eliminates drug-resistant breast cancer cells Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P3-07-14  0.35
2017 Wardell SE, Yllanes AP, Norris JD, Stice JP, White H, Fleming RA, Strum JC, Moore WR, McDonnell DP. Abstract 1588: Effects of the selective CYP17-lyase and androgen receptor (AR) inhibitor, seviteronel, and the cyclin-dependent kinase (CDK) 4/6 inhibitor, G1T38, on tumor growth in an AR-V7+ castration-resistant prostate cancer (CRPC) xenograft model Cancer Research. 77: 1588-1588. DOI: 10.1158/1538-7445.Am2017-1588  0.372
2017 Kimbung S, Chang C, Bendahl P, Dubois L, Thompson W, McDonnell D, Borgquist S. Impact of the sterol 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol on tumor-pathological features, prognosis and response to statin treatment in breast cancer Annals of Oncology. 28: i4. DOI: 10.1093/Annonc/Mdx142.002  0.305
2016 Anderson GR, Wardell SE, Cakir M, Crawford L, Leeds JC, Nussbaum DP, Shankar PS, Soderquist RS, Stein EM, Tingley JP, Winter PS, Zieser-Misenheimer EK, Alley HM, Yllanes A, Haney V, ... ... McDonnell DP, et al. PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation. Science Translational Medicine. 8: 369ra175. PMID 27974663 DOI: 10.1126/Scitranslmed.Aae0348  0.351
2016 Alexander PB, Chen R, Gong C, Yuan L, Jasper JS, Ding Y, Markowitz GJ, Yang P, Xu X, McDonnell DP, Song E, Wang XF. Distinct receptor tyrosine kinase subsets mediate anti-HER2 drug resistance in breast cancer. The Journal of Biological Chemistry. PMID 27903634 DOI: 10.1074/Jbc.M116.754960  0.431
2016 Pollock JA, Wardell SE, Parent AA, Stagg DB, Ellison SJ, Alley HM, Chao CA, Lawrence SA, Stice JP, Spasojevic I, Baker JG, Kim SH, McDonnell DP, Katzenellenbogen JA, Norris JD. Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer. Nature Chemical Biology. PMID 27501397 DOI: 10.1038/Nchembio.2131  0.467
2016 Park S, Chang CY, Safi R, Liu X, Baldi R, Jasper JS, Anderson GR, Liu T, Rathmell JC, Dewhirst MW, Wood KC, Locasale JW, McDonnell DP. ERRα Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. Cell Reports. PMID 27050525 DOI: 10.1016/J.Celrep.2016.03.026  0.439
2016 Xu X, Zhang Y, Jasper J, Lykken E, Alexander PB, Markowitz GJ, McDonnell DP, Li QJ, Wang XF. MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer. Oncotarget. PMID 26967387 DOI: 10.18632/Oncotarget.7953  0.307
2016 Ellison S, Norris J, Wardell S, Eisner J, Hoekstra W, Stagg D, Alley H, Moore W, McDonnell D. Abstract P3-14-04: Effects of the dual selective CYP17 lyase inhibitor and androgen receptor (AR) antagonist, VT-464, on AR+ and ER+ tumor models in vitro and in vivo Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P3-14-04  0.445
2016 Stice JP, White HS, Wardell SE, Yllanes AY, Lawrence SA, Alley H, McDonnell DP, Strum JC. Abstract 2820: Effects of a CDK 4/6 inhibitor, G1T38, in androgen receptor sensitive and resistant models of castrate resistant prostate cancer Cancer Research. 76: 2820-2820. DOI: 10.1158/1538-7445.Am2016-2820  0.371
2015 Blessing AM, Ganesan S, Rajapakshe K, Ying Sung Y, Reddy Bollu L, Shi Y, Cheung E, Coarfa C, Chang JT, McDonnell DP, Frigo DE. Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. Molecular Endocrinology (Baltimore, Md.). 29: 1426-39. PMID 26305679 DOI: 10.1210/Me.2015-1079  0.499
2015 Wardell SE, Nelson ER, Chao CA, Alley HM, McDonnell DP. Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader. Endocrine-Related Cancer. 22: 713-24. PMID 26162914 DOI: 10.1530/Erc-15-0287  0.452
2015 Gustafson JL, Neklesa TK, Cox CS, Roth AG, Buckley DL, Tae HS, Sundberg TB, Stagg DB, Hines J, McDonnell DP, Norris JD, Crews CM. Small-Molecule-Mediated Degradation of the Androgen Receptor Through Hydrophobic Tagging. Angewandte Chemie (International Ed. in English). PMID 26083457 DOI: 10.1002/Anie.201503720  0.448
2015 Lontay B, Bodoor K, Sipos A, Weitzel DH, Loiselle D, Safi R, Zheng D, Devente J, Hickner RC, McDonnell DP, Ribar T, Haystead TA. Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice. The Journal of Biological Chemistry. 290: 17985-98. PMID 26048986 DOI: 10.1074/Jbc.M115.658120  0.313
2015 McDonnell DP, Wardell SE, Norris JD. Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer. Journal of Medicinal Chemistry. 58: 4883-7. PMID 26039356 DOI: 10.1021/Acs.Jmedchem.5B00760  0.469
2015 Wardell SE, Ellis MJ, Alley HM, Eisele K, VanArsdale T, Dann SG, Arndt KT, Primeau T, Griffin E, Shao J, Crowder RJ, Lai JP, Norris JD, McDonnell DP, Li S. Efficacy of SERD/SERM Hybrid-CDK4/6 inhibitor combinations in models of endocrine therapy resistant breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 25991817 DOI: 10.1158/1078-0432.Ccr-15-0360  0.465
2015 Allensworth JL, Evans MK, Bertucci F, Aldrich AJ, Festa RA, Finetti P, Ueno NT, Safi R, McDonnell DP, Thiele DJ, Van Laere S, Devi GR. Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer. Molecular Oncology. 9: 1155-68. PMID 25769405 DOI: 10.1016/J.Molonc.2015.02.007  0.317
2015 Choudhary M, Kazmin D, Hu P, Thomas RS, McDonnell DP, Malek G. Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways. The Journal of Pathology. 235: 101-12. PMID 25186463 DOI: 10.1002/Path.4433  0.363
2015 Moore WR, Norris JD, Wardell S, Eisner JR, Hoekstra WJ, Schotzinger RJ, McDonnell DP. Direct effects of the selective CYP17 lyase (L) inhibitor, VT-464, on the androgen receptor (AR) and its oral activity in an F876L tumor mouse xenograft model. Journal of Clinical Oncology. 33: 263-263. DOI: 10.1200/Jco.2015.33.7_Suppl.263  0.345
2015 Nelson ER, Wardell SE, McDonnell DP. Abstract A82: The cholesterol metabolite, 27-hydroxycholesterol, promotes breast cancer metastasis Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-A82  0.397
2015 Alfaqih MA, Nelson ER, Safi R, Jasper J, McDonnell DP, Freedland SJ. Abstract PR11: Dysregulation of cholesterol homeostasis through loss of CYP27A1 in prostate cancer; Implications for early detection and prevention of over-treatment Cancer Prevention Research. 8. DOI: 10.1158/1940-6215.Prev-14-Pr11  0.336
2015 Alwarawrah Y, Hughes P, Safi R, McDonnell DP, Spector NL, Haystead TA. Abstract 2703: Overcoming Lapatinib resistance by the fatty acid synthase inhibitor HS-106 Cancer Research. 75: 2703-2703. DOI: 10.1158/1538-7445.Am2015-2703  0.379
2014 Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, Anderson GR, Winter PS, Wang T, Alley HM, Kwong LN, Cooper ZA, Tetzlaff M, Chen PL, Rathmell JC, ... ... McDonnell DP, et al. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Science Signaling. 7: ra121. PMID 25538079 DOI: 10.1126/Scisignal.Aaa1877  0.368
2014 Nelson ER, Chang CY, McDonnell DP. Cholesterol and breast cancer pathophysiology. Trends in Endocrinology and Metabolism: Tem. 25: 649-55. PMID 25458418 DOI: 10.1016/J.Tem.2014.10.001  0.43
2014 Safi R, Nelson ER, Chitneni SK, Franz KJ, George DJ, Zalutsky MR, McDonnell DP. Copper signaling axis as a target for prostate cancer therapeutics. Cancer Research. 74: 5819-31. PMID 25320179 DOI: 10.1158/0008-5472.Can-13-3527  0.325
2014 McDonnell DP, Chang CY, Nelson ER. The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer. Climacteric : the Journal of the International Menopause Society. 17: 60-5. PMID 25320023 DOI: 10.3109/13697137.2014.966949  0.381
2014 Wright TM, Wardell SE, Jasper JS, Stice JP, Safi R, Nelson ER, McDonnell DP. Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer. Molecular Cancer Research : McR. 12: 1829-39. PMID 25100862 DOI: 10.1158/1541-7786.Mcr-14-0195  0.435
2014 Gustafsson JA, Katzenellenbogen B, Jameson JL, Roth J, Melmed S, McDonnell D, Wartofsky L, Crowley WF, Griz LH, Becker C, Moore DD, Drucker D, Singh N, O'Malley B. Endocrine Society 2014 Laureate Awards. Hormones & Cancer. 5: 339-55. PMID 25091407 DOI: 10.1007/S12672-014-0193-Y  0.368
2014 Wardell SE, Nelson ER, McDonnell DP. From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs). Steroids. 90: 30-8. PMID 25084324 DOI: 10.1016/J.Steroids.2014.07.013  0.545
2014 McDonnell DP, Park S, Goulet MT, Jasper J, Wardell SE, Chang CY, Norris JD, Guyton JR, Nelson ER. Obesity, cholesterol metabolism, and breast cancer pathogenesis. Cancer Research. 74: 4976-82. PMID 25060521 DOI: 10.1158/0008-5472.Can-14-1756  0.384
2014 Yang J, Fuller PJ, Morgan J, Shibata H, McDonnell DP, Clyne CD, Young MJ. Use of phage display to identify novel mineralocorticoid receptor-interacting proteins. Molecular Endocrinology (Baltimore, Md.). 28: 1571-84. PMID 25000480 DOI: 10.1210/Me.2014-1101  0.35
2014 Scholtz EL, Krishnan S, Ball BA, Corbin CJ, Moeller BC, Stanley SD, McDowell KJ, Hughes AL, McDonnell DP, Conley AJ. Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone receptor agonist, 5α-dihydroprogesterone. Proceedings of the National Academy of Sciences of the United States of America. 111: 3365-70. PMID 24550466 DOI: 10.1073/Pnas.1318163111  0.361
2014 Weiser PT, Chang CY, McDonnell DP, Hanson RN. 4,4'-Unsymmetrically substituted 3,3'-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors. Bioorganic & Medicinal Chemistry. 22: 917-26. PMID 24360824 DOI: 10.1016/J.Bmc.2013.10.051  0.395
2014 Shatnawi A, Norris JD, Chaveroux C, Jasper JS, Sherk AB, McDonnell DP, Giguère V. ELF3 is a repressor of androgen receptor action in prostate cancer cells. Oncogene. 33: 862-71. PMID 23435425 DOI: 10.1038/Onc.2013.15  0.818
2014 Stevens EV, Whitaker R, Guinet A, Chang C, Grenier C, Marks J, McDonnell DP, Murphy SK, Berchuck A, Gaillard S. Abstract 4570: Role of ERRalpha in ovarian cancer Cancer Research. 74: 4570-4570. DOI: 10.1158/1538-7445.Am2014-4570  0.416
2014 Alfaqih MA, Nelson ER, Safi R, Jasper J, Chang C, Freedland SJ, McDonnell DP. Abstract 3311: The cholesterol/ 27-hydroxycholesterol axis is a novel therapeutic target in castrate resistant prostate cancer Cancer Research. 74: 3311-3311. DOI: 10.1158/1538-7445.Am2014-3311  0.404
2013 Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, Howe MK, Carver NJ, Pillai RV, Sullivan PM, Sondhi V, Umetani M, Geradts J, McDonnell DP. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science (New York, N.Y.). 342: 1094-8. PMID 24288332 DOI: 10.1126/Science.1241908  0.402
2013 Hu P, Herrmann R, Bednar A, Saloupis P, Dwyer MA, Yang P, Qi X, Thomas RS, Jaffe GJ, Boulton ME, McDonnell DP, Malek G. Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. Proceedings of the National Academy of Sciences of the United States of America. 110: E4069-78. PMID 24106308 DOI: 10.1073/Pnas.1307574110  0.381
2013 Wardell SE, Nelson ER, Chao CA, McDonnell DP. Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2420-31. PMID 23536434 DOI: 10.1158/1078-0432.Ccr-12-3771  0.457
2013 Augello MA, Burd CJ, Birbe R, McNair C, Ertel A, Magee MS, Frigo DE, Wilder-Romans K, Shilkrut M, Han S, Jernigan DL, Dean JL, Fatatis A, McDonnell DP, Visakorpi T, et al. Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes. The Journal of Clinical Investigation. 123: 493-508. PMID 23257359 DOI: 10.1172/Jci64750  0.413
2013 Shi Y, Han JJ, Tennakoon JB, Mehta FF, Merchant FA, Burns AR, Howe MK, McDonnell DP, Frigo DE. Androgens promote prostate cancer cell growth through induction of autophagy. Molecular Endocrinology (Baltimore, Md.). 27: 280-95. PMID 23250485 DOI: 10.1210/Me.2012-1260  0.331
2013 Nelson ER, Wardell SE, McDonnell DP. The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis. Bone. 53: 42-50. PMID 23168292 DOI: 10.1016/J.Bone.2012.11.011  0.455
2013 Nelson ER, Wardell SE, Howe MK, Carver NJ, Umetani M, McDonnell DP. Abstract PR3: The cholesterol metabolite 27-hydroxycholesterol increases breast cancer tumor growth and metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-Pr3  0.373
2013 Wright TM, Wardell SE, Nelson ER, McDonnell DP. Abstract A96: The role of the proto-oncogene AGR2 in endocrine resistant breast cancer. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-A96  0.422
2013 Wardell SE, McDonnell DP, Nelson ER. Regulation of Bone Cell Function by Estrogens Osteoporosis: Fourth Edition. 329-344. DOI: 10.1016/B978-0-12-415853-5.00014-5  0.427
2012 Chang CY, McDonnell DP. Molecular pathways: the metabolic regulator estrogen-related receptor α as a therapeutic target in cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 6089-95. PMID 23019305 DOI: 10.1158/1078-0432.Ccr-11-3221  0.5
2012 Weiser PT, Williams AB, Chang CY, McDonnell DP, Hanson RN. 3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding. Bioorganic & Medicinal Chemistry Letters. 22: 6587-90. PMID 23017882 DOI: 10.1016/J.Bmcl.2012.09.007  0.404
2012 Wardell SE, Kazmin D, McDonnell DP. Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes. Molecular Endocrinology (Baltimore, Md.). 26: 1235-48. PMID 22570330 DOI: 10.1210/Me.2012-1031  0.553
2012 Pollock JA, Larrea MD, Jasper JS, McDonnell DP, McCafferty DG. Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners. Acs Chemical Biology. 7: 1221-31. PMID 22533360 DOI: 10.1021/Cb300108C  0.439
2012 Malek G, Dwyer M, McDonnell D. Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD Advances in Experimental Medicine and Biology. 723: 51-59. PMID 22183315 DOI: 10.1007/978-1-4614-0631-0_8  0.353
2011 Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, et al. Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 108: 18348-53. PMID 22042850 DOI: 10.1073/Pnas.1108856108  0.361
2011 Chang CY, Kazmin D, Jasper JS, Kunder R, Zuercher WJ, McDonnell DP. The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. Cancer Cell. 20: 500-10. PMID 22014575 DOI: 10.1016/J.Ccr.2011.08.023  0.458
2011 Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M, Rathmell JC, Khosla S, Gesty-Palmer D, McDonnell DP. The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology. 152: 4691-705. PMID 21933863 DOI: 10.1210/En.2011-1298  0.786
2011 Bodoor K, Lontay B, Safi R, Weitzel DH, Loiselle D, Wei Z, Lengyel S, McDonnell DP, Haystead TA. Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy. The Journal of Biological Chemistry. 286: 31839-51. PMID 21771785 DOI: 10.1074/Jbc.M111.270397  0.463
2011 Wardell SE, Marks JR, McDonnell DP. The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy. Biochemical Pharmacology. 82: 122-30. PMID 21501600 DOI: 10.1016/J.Bcp.2011.03.031  0.526
2011 Dwyer MA, Kazmin D, Hu P, McDonnell DP, Malek G. Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration. Molecular Endocrinology (Baltimore, Md.). 25: 360-72. PMID 21239617 DOI: 10.1210/Me.2010-0392  0.437
2011 Yang J, Chang CY, Safi R, Morgan J, McDonnell DP, Fuller PJ, Clyne CD, Young MJ. Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display. Molecular Endocrinology (Baltimore, Md.). 25: 32-43. PMID 21106883 DOI: 10.1210/Me.2010-0193  0.449
2011 Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR, McDonnell DP. CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells. Cancer Research. 71: 528-37. PMID 21098087 DOI: 10.1158/0008-5472.Can-10-2581  0.357
2011 Wade H, McDonnell D, Brown M. Abstract 4542: Dose-dependent effects of progestins on progesterone receptor activity and target gene expression: less is more Cancer Research. 71: 4542-4542. DOI: 10.1158/1538-7445.Am2011-4542  0.451
2010 Kobayashi S, Stice JP, Kazmin D, Wittmann BM, Kimbrel EA, Edwards DP, Chang CY, McDonnell DP. Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer. Molecular Endocrinology (Baltimore, Md.). 24: 2292-302. PMID 20980435 DOI: 10.1210/Me.2010-0289  0.802
2010 McDonnell DP, Wardell SE. The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer. Current Opinion in Pharmacology. 10: 620-8. PMID 20926342 DOI: 10.1016/J.Coph.2010.09.007  0.502
2010 Dwyer MA, Joseph JD, Wade HE, Eaton ML, Kunder RS, Kazmin D, Chang CY, McDonnell DP. WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration. Cancer Research. 70: 9298-308. PMID 20870744 DOI: 10.1158/0008-5472.Can-10-0226  0.757
2010 Orr CR, Montie HL, Liu Y, Bolzoni E, Jenkins SC, Wilson EM, Joseph JD, McDonnell DP, Merry DE. An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. The Journal of Biological Chemistry. 285: 35567-77. PMID 20826791 DOI: 10.1074/Jbc.M110.146845  0.386
2010 DuSell CD, Nelson ER, Wang X, Abdo J, Mödder UI, Umetani M, Gesty-Palmer D, Javitt NB, Khosla S, McDonnell DP. The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. Endocrinology. 151: 3675-85. PMID 20501668 DOI: 10.1210/En.2010-0080  0.791
2010 Wade HE, Kobayashi S, Eaton ML, Jansen MS, Lobenhofer EK, Lupien M, Geistlinger TR, Zhu W, Nevins JR, Brown M, Otteson DC, McDonnell DP. Multimodal regulation of E2F1 gene expression by progestins. Molecular and Cellular Biology. 30: 1866-77. PMID 20123965 DOI: 10.1128/Mcb.01060-09  0.767
2010 Muramoto GG, Russell JL, Safi R, Salter AB, Himburg HA, Daher P, Meadows SK, Doan P, Storms RW, Chao NJ, McDonnell DP, Chute JP. Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. Stem Cells (Dayton, Ohio). 28: 523-34. PMID 20054864 DOI: 10.1002/Stem.299  0.307
2010 Hall JM, Barhoover MA, Kazmin D, McDonnell DP, Greenlee WF, Thomas RS. Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation. Molecular Endocrinology (Baltimore, Md.). 24: 359-69. PMID 20032195 DOI: 10.1210/Me.2009-0346  0.694
2010 Zhou XE, Suino-Powell K, Ludidi PL, McDonnell DP, Xu HE. Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs. Protein Expression and Purification. 71: 21-7. PMID 19995608 DOI: 10.1016/J.Pep.2009.12.002  0.411
2010 Chute JP, Ross JR, McDonnell DP. Minireview: Nuclear receptors, hematopoiesis, and stem cells. Molecular Endocrinology (Baltimore, Md.). 24: 1-10. PMID 19934345 DOI: 10.1210/Me.2009-0332  0.328
2010 DuSell CD, Nelson ER, Wittmann BM, Fretz JA, Kazmin D, Thomas RS, Pike JW, McDonnell DP. Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Molecular Endocrinology (Baltimore, Md.). 24: 33-46. PMID 19901195 DOI: 10.1210/Me.2009-0339  0.858
2010 Kobayashi S, Stice JP, Kazmin D, Wittmann BM, Kimbrel EA, Edwards DP, Chang C, McDonnell DP. Mechanisms of Progesterone Receptor Inhibition of Inflammatory Responses in Cellular Models of Breast Cancer Endocrine Reviews. 31: 5457-5457. DOI: 10.1210/Edrv.31.6.9984  0.78
2010 Hall JM, Barhoover MA, Kazmin D, McDonnell DP, Greenlee WF, Thomas RS. Activation of the Aryl-Hydrocarbon Receptor Inhibits Invasive and Metastatic Features of Human Breast Cancer Cells and Promotes Breast Cancer Cell Differentiation Endocrine Reviews. 31: 138-138. DOI: 10.1210/Edrv.31.1.9999  0.41
2009 Norris JD, Chang CY, Wittmann BM, Kunder RS, Cui H, Fan D, Joseph JD, McDonnell DP. The homeodomain protein HOXB13 regulates the cellular response to androgens. Molecular Cell. 36: 405-16. PMID 19917249 DOI: 10.1016/J.Molcel.2009.10.020  0.406
2009 Joseph JD, Wittmann BM, Dwyer MA, Cui H, Dye DA, McDonnell DP, Norris JD. Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists. Proceedings of the National Academy of Sciences of the United States of America. 106: 12178-83. PMID 19574450 DOI: 10.1073/Pnas.0900185106  0.516
2009 Frigo DE, Sherk AB, Wittmann BM, Norris JD, Wang Q, Joseph JD, Toner AP, Brown M, McDonnell DP. Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro. Molecular Endocrinology (Baltimore, Md.). 23: 1385-96. PMID 19460858 DOI: 10.1210/Me.2009-0010  0.795
2009 Stein RA, Gaillard S, McDonnell DP. Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 114: 106-12. PMID 19429439 DOI: 10.1016/J.Jsbmb.2009.02.010  0.476
2009 Grasfeder LL, Gaillard S, Hammes SR, Ilkayeva O, Newgard CB, Hochberg RB, Dwyer MA, Chang CY, McDonnell DP. Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. Molecular Endocrinology (Baltimore, Md.). 23: 1171-82. PMID 19389810 DOI: 10.1210/Me.2009-0024  0.787
2009 Norris JD, Joseph JD, Sherk AB, Juzumiene D, Turnbull PS, Rafferty SW, Cui H, Anderson E, Fan D, Dye DA, Deng X, Kazmin D, Chang CY, Willson TM, McDonnell DP. Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands. Chemistry & Biology. 16: 452-60. PMID 19389631 DOI: 10.1016/J.Chembiol.2009.01.016  0.83
2009 Clyne CD, Chang CY, Safi R, Fuller PJ, McDonnell DP, Young MJ. Purification and characterization of recombinant human mineralocorticoid receptor. Molecular and Cellular Endocrinology. 302: 81-5. PMID 19114086 DOI: 10.1016/J.Mce.2008.11.030  0.473
2009 Safi R, Muramoto GG, Salter AB, Meadows S, Himburg H, Russell L, Daher P, Doan P, Leibowitz MD, Chao NJ, McDonnell DP, Chute JP. Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. Molecular Endocrinology (Baltimore, Md.). 23: 188-201. PMID 19106195 DOI: 10.1210/Me.2008-0121  0.426
2009 Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, McDonnell DP. Glucose metabolism as a target of histone deacetylase inhibitors. Molecular Endocrinology (Baltimore, Md.). 23: 388-401. PMID 19106193 DOI: 10.1210/Jcem.94.2.9997  0.303
2009 Collins NH, Lessey EC, DuSell CD, McDonnell DP, Fowler L, Palomino WA, Illera MJ, Yu X, Mo B, Houwing AM, Lessey BA. Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. Biology of Reproduction. 80: 375-83. PMID 18923163 DOI: 10.1095/Biolreprod.107.065375  0.815
2008 Stein RA, Chang CY, Kazmin DA, Way J, Schroeder T, Wergin M, Dewhirst MW, McDonnell DP. Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. Cancer Research. 68: 8805-12. PMID 18974123 DOI: 10.1158/0008-5472.Can-08-1594  0.507
2008 Sherk AB, Frigo DE, Schnackenberg CG, Bray JD, Laping NJ, Trizna W, Hammond M, Patterson JR, Thompson SK, Kazmin D, Norris JD, McDonnell DP. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Research. 68: 7475-83. PMID 18794135 DOI: 10.1158/0008-5472.Can-08-1047  0.788
2008 DuSell CD, McDonnell DP. 27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling. Trends in Pharmacological Sciences. 29: 510-4. PMID 18722677 DOI: 10.1016/J.Tips.2008.07.003  0.851
2008 Frigo DE, McDonnell DP. Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation. Molecular Cancer Therapeutics. 7: 659-69. PMID 18347151 DOI: 10.1158/1535-7163.Mct-07-0480  0.38
2008 DuSell CD, Umetani M, Shaul PW, Mangelsdorf DJ, McDonnell DP. 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Molecular Endocrinology (Baltimore, Md.). 22: 65-77. PMID 17872378 DOI: 10.1210/Me.2007-0383  0.839
2008 Grasfeder LL, McDonnell DP. Nuclear receptor cofactor interactions as targets for new drug discovery Nr Coregulators and Human Diseases. 572-599. DOI: 10.1142/9789812819178_0019  0.489
2007 Hyatt SM, Lockamy EL, Stein RA, McDonnell DP, Miller AB, Orband-Miller LA, Willson TM, Zuercher WJ. On the intractability of estrogen-related receptor alpha as a target for activation by small molecules. Journal of Medicinal Chemistry. 50: 6722-4. PMID 18052088 DOI: 10.1021/Jm7012387  0.463
2007 Wittmann BM, Sherk A, McDonnell DP. Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators. Cancer Research. 67: 9549-60. PMID 17909066 DOI: 10.1158/0008-5472.Can-07-1590  0.85
2007 Mettu NB, Stanley TB, Dwyer MA, Jansen MS, Allen JE, Hall JM, McDonnell DP. The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors. Molecular Endocrinology (Baltimore, Md.). 21: 2361-77. PMID 17595321 DOI: 10.1210/Me.2007-0201  0.836
2007 Hall JM, McDonnell DP. The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages. Molecular Endocrinology (Baltimore, Md.). 21: 1756-68. PMID 17488971 DOI: 10.1210/Me.2007-0060  0.675
2007 Heldring N, Pawson T, McDonnell D, Treuter E, Gustafsson JA, Pike AC. Structural insights into corepressor recognition by antagonist-bound estrogen receptors. The Journal of Biological Chemistry. 282: 10449-55. PMID 17283072 DOI: 10.1074/Jbc.M611424200  0.465
2007 Zella LA, Chang CY, McDonnell DP, Pike JW. The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs. Archives of Biochemistry and Biophysics. 460: 206-12. PMID 17254542 DOI: 10.1016/J.Abb.2006.12.016  0.363
2007 Gaillard S, Dwyer MA, McDonnell DP. Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions. Molecular Endocrinology (Baltimore, Md.). 21: 62-76. PMID 17053040 DOI: 10.1210/Me.2006-0179  0.558
2007 Sherk AB, McDonnell DP. Molecular pharmacology of estrogen and progesterone receptors Menopause. 17-28. DOI: 10.1016/B978-012369443-0/50004-1  0.81
2006 Stein RA, McDonnell DP. Estrogen-related receptor α as a therapeutic target in cancer Endocrine-Related Cancer. 13. PMID 17259555 DOI: 10.1677/Erc.1.01292  0.543
2006 Gaillard S, Grasfeder LL, Haeffele CL, Lobenhofer EK, Chu TM, Wolfinger R, Kazmin D, Koves TR, Muoio DM, Chang CY, McDonnell DP. Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs. Molecular Cell. 24: 797-803. PMID 17157261 DOI: 10.1016/J.Molcel.2006.10.012  0.835
2006 McDonnell DP. Mechanism-based discovery as an approach to identify the next generation of estrogen receptor modulators. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2432-4. PMID 17142791 DOI: 10.1096/Fj.06-1202Ufm  0.547
2006 Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL, Wilson EM, McDonnell DP, Cidlowski JA. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacological Reviews. 58: 782-97. PMID 17132855 DOI: 10.1124/Pr.58.4.9  0.503
2006 Zhang Y, Ma K, Sadana P, Chowdhury F, Gaillard S, Wang F, McDonnell DP, Unterman TG, Elam MB, Park EA. Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. The Journal of Biological Chemistry. 281: 39897-906. PMID 17079227 DOI: 10.1074/Jbc.M608657200  0.405
2006 Chute JP, Muramoto GG, Whitesides J, Colvin M, Safi R, Chao NJ, McDonnell DP. Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 11707-12. PMID 16857736 DOI: 10.1073/Pnas.0603806103  0.34
2006 Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Human PXR forms a tryptophan zipper-mediated homodimer. Biochemistry. 45: 8579-89. PMID 16834332 DOI: 10.1021/Bi0602821  0.482
2006 Kazmin D, Prytkova T, Cook CE, Wolfinger R, Chu TM, Beratan D, Norris JD, Chang CY, McDonnell DP. Linking ligand-induced alterations in androgen receptor structure to differential gene expression: A first step in the rational design of selective androgen receptor modulators Molecular Endocrinology. 20: 1201-1217. PMID 16574741 DOI: 10.1210/Me.2005-0309  0.472
2006 Chao EY, Collins JL, Gaillard S, Miller AB, Wang L, Orband-Miller LA, Nolte RT, McDonnell DP, Willson TM, Zuercher WJ. Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorganic & Medicinal Chemistry Letters. 16: 821-4. PMID 16307879 DOI: 10.1016/J.Bmcl.2005.11.030  0.42
2006 Stein R, Way JM, McDonnell DP, Zuercher WJ. Estrogen-related receptor α as a therapeutic target Drugs of the Future. 31: 427-436. DOI: 10.1358/Dof.2006.031.05.994706  0.42
2006 Muramoto GG, Safi R, Salter A, Himburg H, Chao NJ, McDonnell D, Chute JP. The Retinoid X Receptor Regulates Human Hematopoietic Stem Cell Fate. Blood. 108: 1324-1324. DOI: 10.1182/Blood.V108.11.1324.1324  0.372
2005 Juzumiene D, Chang CY, Fan D, Hartney T, Norris JD, McDonnell DP. Single-step purification of full-length human androgen receptor. Nuclear Receptor Signaling. 3: e001. PMID 16604169 DOI: 10.1621/Nrs.03001  0.462
2005 Hall JM, McDonnell DP. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Molecular Interventions. 5: 343-57. PMID 16394250 DOI: 10.1124/Mi.5.6.7  0.709
2005 Safi R, Kovacic A, Gaillard S, Murata Y, Simpson ER, McDonnell DP, Clyne CD. Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. Cancer Research. 65: 11762-70. PMID 16357189 DOI: 10.1158/0008-5472.Can-05-2792  0.527
2005 Solomon IH, Hager JM, Safi R, McDonnell DP, Redinbo MR, Ortlund EA. Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. Journal of Molecular Biology. 354: 1091-102. PMID 16289203 DOI: 10.1016/J.Jmb.2005.10.009  0.395
2005 Chang CY, Abdo J, Hartney T, McDonnell DP. Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display. Molecular Endocrinology (Baltimore, Md.). 19: 2478-90. PMID 16051662 DOI: 10.1210/Me.2005-0072  0.516
2005 Wu YL, Yang X, Ren Z, McDonnell DP, Norris JD, Willson TM, Greene GL. Structural basis for an unexpected mode of SERM-Mediated ER antagonism Molecular Cell. 18: 413-424. PMID 15893725 DOI: 10.1016/J.Molcel.2005.04.014  0.43
2005 Chang CY, McDonnell DP. Androgen receptor-cofactor interactions as targets for new drug discovery. Trends in Pharmacological Sciences. 26: 225-8. PMID 15860367 DOI: 10.1016/J.Tips.2005.03.002  0.501
2005 Zuercher WJ, Gaillard S, Orband-Miller LA, Chao EY, Shearer BG, Jones DG, Miller AB, Collins JL, McDonnell DP, Willson TM. Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. Journal of Medicinal Chemistry. 48: 3107-9. PMID 15857113 DOI: 10.1021/Jm050161J  0.547
2005 Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nature Structural & Molecular Biology. 12: 357-63. PMID 15723037 DOI: 10.1038/Nsmb910  0.505
2005 Shaffer PL, McDonnell DP, Gewirth DT. Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor. Biochemistry. 44: 2678-85. PMID 15709781 DOI: 10.1021/Bi0477182  0.415
2005 McDonnell DP. The molecular pharmacology of estrogen receptor modulators: implications for the treatment of breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 871s-7s. PMID 15701880  0.42
2005 Chute JP, Muramoto GG, Whitesides J, Colvin M, Saffi R, Chao NJ, McDonnell D. Modulation of Aldehyde Dehydrogenase and Retinoid Signaling Induces the Expansion of Human Hematopoietic Stem Cells. Blood. 106: 1713-1713. DOI: 10.1182/Blood.V106.11.1713.1713  0.345
2004 McDonnell DP. The molecular determinants of estrogen receptor pharmacology. Maturitas. 48: S7-12. PMID 15337242 DOI: 10.1016/J.Maturitas.2004.03.006  0.582
2004 Shao W, Keeton EK, McDonnell DP, Brown M. Coactivator AIB1 links estrogen receptor transcriptional activity and stability. Proceedings of the National Academy of Sciences of the United States of America. 101: 11599-604. PMID 15289619 DOI: 10.1073/Pnas.0402997101  0.488
2004 Turgeon JL, McDonnell DP, Martin KA, Wise PM. Hormone therapy: physiological complexity belies therapeutic simplicity. Science (New York, N.Y.). 304: 1269-73. PMID 15166356 DOI: 10.1126/Science.1096725  0.348
2004 Jansen MS, Nagel SC, Miranda PJ, Lobenhofer EK, Afshari CA, McDonnell DP. Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. Proceedings of the National Academy of Sciences of the United States of America. 101: 7199-204. PMID 15103026 DOI: 10.1073/Pnas.0402014101  0.475
2004 Glass CK, McDonnell DP. The jensen symposium; a tribute to a pioneer in the field of nuclear receptor biology. Molecular Cell. 13: 459-67. PMID 14992717 DOI: 10.1016/S1097-2765(04)00093-0  0.476
2004 Kurebayashi S, Nakajima T, Kim SC, Chang CY, McDonnell DP, Renaud JP, Jetten AM. Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. Biochemical and Biophysical Research Communications. 315: 919-27. PMID 14985100 DOI: 10.1016/J.Bbrc.2004.01.131  0.438
2004 Tirado OM, Selva DM, Toràn N, Suárez-Quian CA, Jansen M, McDonnell DP, Reventós J, Munell F. Increased expression of estrogen receptor beta in pachytene spermatocytes after short-term methoxyacetic acid administration. Journal of Andrology. 25: 84-94. PMID 14662790 DOI: 10.1002/J.1939-4640.2004.Tb02762.X  0.419
2003 Sathya G, Chang CY, Kazmin D, Cook CE, McDonnell DP. Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion. Cancer Research. 63: 8029-36. PMID 14633736  0.414
2003 Chang CY, Norris JD, Jansen M, Huang HJ, McDonnell DP. Application of random peptide phage display to the study of nuclear hormone receptors. Methods in Enzymology. 364: 118-42. PMID 14631842 DOI: 10.1016/S0076-6879(03)64007-3  0.385
2003 McDonnell DP. Mining the complexities of the estrogen signaling pathways for novel therapeutics. Endocrinology. 144: 4237-40. PMID 14500558 DOI: 10.1210/En.2003-0900  0.318
2003 Rincavage HL, McDonnell DP, Kuhn CM. Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells. Endocrinology. 144: 2829-35. PMID 12810537 DOI: 10.1210/En.2002-221120  0.489
2003 Pike JW, Pathrose P, Barmina O, Chang CY, McDonnell DP, Yamamoto H, Shevde NK. Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription. Journal of Cellular Biochemistry. 88: 252-8. PMID 12520523 DOI: 10.1002/Jcb.10336  0.31
2003 Kimbrel EA, McDonnell DP. Function and mode of action of nuclear receptors: Estrogen, progesterone, and vitamin D Pure and Applied Chemistry. 75: 1671-1683. DOI: 10.1351/Pac200375111671  0.821
2002 Sathya G, Jansen MS, Nagel SC, Cook CE, McDonnell DP. Identification and Characterization of Novel Estrogen Receptor-β-Sparing Antiprogestins. Endocrinology. 143: 3071-3082. PMID 28201467 DOI: 10.1210/endo.143.8.8942  0.322
2002 Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, McDonnell D. Problems for risk assessment of endocrine-active estrogenic compounds. Environmental Health Perspectives. 110: 925-9. PMID 12634121 DOI: 10.1289/Ehp.02110S6925  0.535
2002 Pathrose P, Barmina O, Chang CY, McDonnell DP, Shevde NK, Pike JW. Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 17: 2196-205. PMID 12469913 DOI: 10.1359/Jbmr.2002.17.12.2196  0.365
2002 Huang HJ, Norris JD, McDonnell DP. Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists. Molecular Endocrinology (Baltimore, Md.). 16: 1778-92. PMID 12145334 DOI: 10.1210/Me.2002-0089  0.509
2002 Sathya G, Jansen MS, Nagel SC, Cook CE, McDonnell DP. Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins. Endocrinology. 143: 3071-82. PMID 12130573 DOI: 10.1210/Endo.143.8.8942  0.575
2002 McDonnell DP, Wijayaratne A, Chang CY, Norris JD. Elucidation of the molecular mechanism of action of selective estrogen receptor modulators. The American Journal of Cardiology. 90: 35F-43F. PMID 12106639 DOI: 10.1016/S0002-9149(01)02221-4  0.832
2002 Li X, Kimbrel EA, Kenan DJ, McDonnell DP. Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation. Molecular Endocrinology (Baltimore, Md.). 16: 1482-91. PMID 12089344 DOI: 10.1210/Mend.16.7.0860  0.781
2002 McDonnell DP, Norris JD. Connections and regulation of the human estrogen receptor. Science (New York, N.Y.). 296: 1642-4. PMID 12040178 DOI: 10.1126/Science.1071884  0.567
2002 McDonnell DP, Connor CE, Wijayaratne A, Chang CY, Norris JD. Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators. Recent Progress in Hormone Research. 57: 295-316. PMID 12017549 DOI: 10.1210/Rp.57.1.295  0.821
2002 Li X, McDonnell DP. The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. Molecular and Cellular Biology. 22: 3663-73. PMID 11997503 DOI: 10.1128/Mcb.22.11.3663-3673.2002  0.343
2002 Herrington DM, Howard TD, Brosnihan KB, McDonnell DP, Li X, Hawkins GA, Reboussin DM, Xu J, Zheng SL, Meyers DA, Bleecker ER. Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein. Circulation. 105: 1879-82. PMID 11997270 DOI: 10.1161/01.Cir.0000016173.98826.88  0.432
2002 Chang CY, McDonnell DP. Evaluation of ligand-dependent changes in AR structure using peptide probes. Molecular Endocrinology (Baltimore, Md.). 16: 647-60. PMID 11923463 DOI: 10.1210/Mend.16.4.0818  0.412
2002 Weatherman RV, Chang CY, Clegg NJ, Carroll DC, Day RN, Baxter JD, McDonnell DP, Scanlan TS, Schaufele F. Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer. Molecular Endocrinology (Baltimore, Md.). 16: 487-96. PMID 11875107 DOI: 10.1210/Mend.16.3.0813  0.471
2002 Hall JM, McDonnell DP, Korach KS. Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. Molecular Endocrinology (Baltimore, Md.). 16: 469-86. PMID 11875105 DOI: 10.1210/Mend.16.3.0814  0.725
2002 Norris JD, Fan D, Sherk A, McDonnell DP. A negative coregulator for the human ER. Molecular Endocrinology (Baltimore, Md.). 16: 459-68. PMID 11875103 DOI: 10.1210/Mend.16.3.0787  0.818
2002 McDonnell DP, Chang CY, Norris JD. Capitalizing on the complexities of estrogen receptor pharmacology in the quest for the perfect SERM. Annals of the New York Academy of Sciences. 949: 16-35. PMID 11795348 DOI: 10.1111/J.1749-6632.2001.Tb03999.X  0.483
2001 Nagel SC, Hagelbarger JL, McDonnell DP. Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. Endocrinology. 142: 4721-8. PMID 11606437 DOI: 10.1210/Endo.142.11.8471  0.506
2001 Wijayaratne AL, McDonnell DP. The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. The Journal of Biological Chemistry. 276: 35684-92. PMID 11473106 DOI: 10.1074/Jbc.M101097200  0.842
2001 Norris JD, Chang C, McDonnell DP. Estrogen receptor-cofactor interactions as targets for novel drug discovery Ernst Schering Research Foundation Workshop. 181-201. PMID 11394045 DOI: 10.1007/978-3-662-04645-6_10  0.332
2001 Hamilton MH, Tcherepanova I, Huibregtse JM, McDonnell DP. Nuclear Import/Export of hRPF1/Nedd4 Regulates the Ubiquitin-dependent Degradation of Its Nuclear Substrates Journal of Biological Chemistry. 276: 26324-26331. PMID 11342538 DOI: 10.1074/Jbc.M101205200  0.33
2001 Connor CE, Norris JD, Broadwater G, Willson TM, Gottardis MM, Dewhirst MW, McDonnell DP. Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. Cancer Research. 61: 2917-22. PMID 11306468  0.732
2001 McDonnell DP, Chang CY, Norris JD. Development of peptide antagonists that target estrogen receptor-cofactor interactions. The Journal of Steroid Biochemistry and Molecular Biology. 74: 327-35. PMID 11162941 DOI: 10.1016/S0960-0760(00)00109-6  0.529
2000 Schaufele F, Chang Cy, Liu W, Baxter JD, Nordeen SK, Wan Y, Day RN, McDonnell DP. Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor Molecular Endocrinology. 14: 2024-2039. PMID 11117532 DOI: 10.1210/Mend.14.12.0572  0.446
2000 Hall JM, Chang CY, McDonnell DP. Development of peptide antagonists that target estrogen receptor beta-coactivator interactions. Molecular Endocrinology (Baltimore, Md.). 14: 2010-23. PMID 11117531 DOI: 10.1210/Mend.14.12.0561  0.681
2000 Gaido KW, Maness SC, McDonnell DP, Dehal SS, Kupfer D, Safe S. Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. Molecular Pharmacology. 58: 852-8. PMID 10999957  0.427
2000 Giangrande PH, Kimbrel EA, Edwards DP, McDonnell DP. The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Molecular and Cellular Biology. 20: 3102-15. PMID 10757795 DOI: 10.1128/Mcb.20.9.3102-3115.2000  0.819
2000 Tcherepanova I, Puigserver P, Norris JD, Spiegelman BM, McDonnell DP. Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. The Journal of Biological Chemistry. 275: 16302-8. PMID 10748020 DOI: 10.1074/Jbc.M001364200  0.488
2000 McDonnell DP. Selective estrogen receptor modulators (SERMs): A first step in the development of perfect hormone replacement therapy regimen Journal of the Society For Gynecologic Investigation. 7. PMID 10732322 DOI: 10.1016/S1071-5576(99)00055-6  0.55
2000 McDonnell DP. Selective Estrogen Receptor Modulators (SERMs): A First Step in the Development of Perfect Hormone Replacement Therapy Regimen Journal of the Society For Gynecologic Investigation. 7: S10-S15. DOI: 10.1177/1071557600007001S05  0.348
2000 Gaido KW, Maness SC, McDonnell DP, Dehal SS, Kupfer D, Safe S. Interaction of Methoxychlor and Related Compounds with Estrogen Receptor α and β, and Androgen Receptor: Structure-Activity Studies Molecular Pharmacology. 58: 852-858. DOI: 10.1124/Mol.58.4.852  0.518
1999 Wijayaratne AL, Nagel SC, Paige LA, Christensen DJ, Norris JD, Fowlkes DM, McDonnell DP. Comparative Analyses of Mechanistic Differences Among Antiestrogens1. Endocrinology. 140: 5828-5840. PMID 28200824 DOI: 10.1210/endo.140.12.7164  0.743
1999 Hall JM, McDonnell DP. The Estrogen Receptor β-Isoform (ERβ) of the Human Estrogen Receptor Modulates ERα Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens1. Endocrinology. 140: 5566-5578. PMID 28200448 DOI: 10.1210/endo.140.12.7179  0.451
1999 Wijayaratne AL, Nagel SC, Paige LA, Christensen DJ, Norris JD, Fowlkes DM, McDonnell DP. Comparative analyses of mechanistic differences among antiestrogens. Endocrinology. 140: 5828-40. PMID 10579349 DOI: 10.1210/Endo.140.12.7164  0.83
1999 Gaido KW, Leonard LS, Maness SC, Hall JM, McDonnell DP, Saville B, Safe S. Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. Endocrinology. 140: 5746-53. PMID 10579340 DOI: 10.1210/Endo.140.12.7191  0.7
1999 Hall JM, McDonnell DP. The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology. 140: 5566-78. PMID 10579320 DOI: 10.1210/Endo.140.12.7179  0.727
1999 Chang CY, Norris JD, Grøn H, Paige LA, Hamilton PT, Kenan DJ, Fowlkes D, McDonnell DP. Dissection of the LXXLL Nuclear Receptor-Coactivator Interaction Motif Using Combinatorial Peptide Libraries: Discovery of Peptide Antagonists of Estrogen Receptors α and β Molecular and Cellular Biology. 19: 8226-8239. PMID 10567548 DOI: 10.1128/Mcb.19.12.8226  0.536
1999 Norris JD, Paige LA, Christensen DJ, Chang CY, Huacani MR, Fan D, Hamilton PT, Fowlkes DM, McDonnell DP. Peptide antagonists of the human estrogen receptor. Science (New York, N.Y.). 285: 744-6. PMID 10426998 DOI: 10.1126/Science.285.5428.744  0.546
1999 Tetel MJ, Giangrande PH, Leonhardt SA, McDonnell DP, Edwards DP. Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. Molecular Endocrinology (Baltimore, Md.). 13: 910-24. PMID 10379890 DOI: 10.1210/Mend.13.6.0300  0.389
1999 Improta-Brears T, Whorton AR, Codazzi F, York JD, Meyer T, McDonnell DP. Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. Proceedings of the National Academy of Sciences of the United States of America. 96: 4686-91. PMID 10200323 DOI: 10.1073/pnas.96.8.4686  0.357
1999 Paige LA, Christensen DJ, Grøn H, Norris JD, Gottlin EB, Padilla KM, Chang CY, Ballas LM, Hamilton PT, McDonnell DP, Fowlkes DM. Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. Proceedings of the National Academy of Sciences of the United States of America. 96: 3999-4004. PMID 10097152 DOI: 10.1073/Pnas.96.7.3999  0.524
1999 Wagner BL, Pollio G, Giangrande P, Webster JC, Breslin M, Mais DE, Cook CE, Vedeckis WV, Cidlowski JA, McDonnell DP. The novel progesterone receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex glucocorticoid receptor antagonist activities: implications for the development of dissociated antiprogestins. Endocrinology. 140: 1449-58. PMID 10067874 DOI: 10.1210/Endo.140.3.6581  0.537
1998 McDonnell DP. Definition of the molecular mechanism of action of tissue-selective oestrogen-receptor modulators Biochemical Society Transactions. 26: 54-60. PMID 10909757 DOI: 10.1042/Bst0260054  0.445
1998 Gould JC, Leonard LS, Maness SC, Wagner BL, Conner K, Zacharewski T, Safe S, McDonnell DP, Gaido KW. Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. Molecular and Cellular Endocrinology. 142: 203-14. PMID 9783916 DOI: 10.1016/S0303-7207(98)00084-7  0.461
1998 Maness SC, McDonnell DP, Gaido KW. Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. Toxicology and Applied Pharmacology. 151: 135-42. PMID 9705896 DOI: 10.1006/Taap.1998.8431  0.486
1998 Norris JD, Fan D, Stallcup MR, McDonnell DP. Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology Journal of Biological Chemistry. 273: 6679-6688. PMID 9506965 DOI: 10.1074/Jbc.273.12.6679  0.554
1998 Wagner BL, Norris JD, Knotts TA, Weigel NL, McDonnell DP. The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor. Molecular and Cellular Biology. 18: 1369-78. PMID 9488452 DOI: 10.1128/Mcb.18.3.1369  0.566
1997 Giangrande PH, Pollio G, McDonnell DP. Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor Journal of Biological Chemistry. 272: 32889-32900. PMID 9407067 DOI: 10.1074/Jbc.272.52.32889  0.499
1997 Ramamoorthy K, Vyhlidal C, Wang F, Chen I, Safe S, McDonnell DP, Leonard LS, Gaido KW. Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. Toxicology and Applied Pharmacology. 147: 93-100. PMID 9356311 DOI: 10.1006/Taap.1997.8281  0.429
1997 Coldham NG, Dave M, Sivapathasundaram S, McDonnell DP, Connor C, Sauer MJ. Evaluation of a recombinant yeast cell estrogen screening assay. Environmental Health Perspectives. 105: 734-42. PMID 9294720 DOI: 10.1289/Ehp.97105734  0.722
1997 Willson TM, Norris JD, Wagner BL, Asplin I, Baer P, Brown HR, Jones SA, Henke B, Sauls H, Wolfe S, Morris DC, McDonnell DP. Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone. Endocrinology. 138: 3901-11. PMID 9275080 DOI: 10.1210/Endo.138.9.5358  0.508
1997 McDonnell DP, Norris JD. Analysis of the molecular pharmacology of estrogen receptor agonists and antagonists provides insights into the mechanism of action of estrogen in bone Osteoporosis International. 7: 29-34. PMID 9205643 DOI: 10.1007/Bf01674810  0.491
1997 Norris JD, Fan D, Kerner SA, McDonnell DP. Identification of a third autonomous activation domain within the human estrogen receptor Molecular Endocrinology. 11: 747-754. PMID 9171238 DOI: 10.1210/Mend.11.6.0008  0.486
1997 Ramamoorthy K, Wang F, Chen IC, Norris JD, McDonnell DP, Leonard LS, Gaido KW, Bocchinfuso WP, Korach KS, Safe S. Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. Endocrinology. 138: 1520-7. PMID 9075711 DOI: 10.1210/Endo.138.4.5056  0.427
1997 Gaido KW, Leonard LS, Lovell S, Gould JC, Babaï D, Portier CJ, McDonnell DP. Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. Toxicology and Applied Pharmacology. 143: 205-12. PMID 9073609 DOI: 10.1006/Taap.1996.8069  0.51
1997 Marks JR, Huper G, Vaughn JP, Davis PL, Norris J, McDonnell DP, Wiseman RW, Futreal PA, Iglehart JD. BRCA1 expression is not directly responsive to estrogen Oncogene. 14: 115-121. PMID 9010238 DOI: 10.1038/Sj.Onc.1200808  0.453
1997 Ramamoorthy K, Wang F, Chen IC, Safe S, Norris JD, McDonnell DP, Gaido KW, Korach KS, McLachlan JA, Arnold SF, Klotz DM, Collins BM, Vonier PM, Guillette LJ. Potency of combined estrogenic pesticides Science. 275: 405-406. PMID 9005556 DOI: 10.1126/Science.275.5298.405  0.409
1996 Norris JD, Fan D, Wagner BL, McDonnell DP. Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity Molecular Endocrinology. 10: 1605-1616. PMID 8961270 DOI: 10.1210/Mend.10.12.8961270  0.502
1996 Vegeto E, Wagner BL, Imhof MO, McDonnell DP. The molecular pharmacology of ovarian steroid receptors. Vitamins and Hormones. 52: 99-128. PMID 8909158 DOI: 10.1016/S0083-6729(08)60408-2  0.465
1996 Wagner BL, Pollio G, Leonhardt S, Wani MC, Lee DY, Imhof MO, Edwards DP, Cook CE, McDonnell DP. 16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity. Proceedings of the National Academy of Sciences of the United States of America. 93: 8739-44. PMID 8710941 DOI: 10.1073/Pnas.93.16.8739  0.538
1996 Imhof MO, McDonnell DP. Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors Molecular and Cellular Biology. 16: 2594-2605. PMID 8649367 DOI: 10.1128/Mcb.16.6.2594  0.487
1996 McDonnell DP, Clemm DL, Hermann T, Goldman ME, Pike JW. Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. Molecular Endocrinology (Baltimore, Md.). 9: 659-69. PMID 8592512 DOI: 10.1210/Mend.9.6.8592512  0.551
1995 Klein KO, Baron J, Colli MJ, McDonnell DP, Cutler GB. Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay. The Journal of Clinical Investigation. 94: 2475-80. PMID 7989605 DOI: 10.1172/Jci117616  0.383
1995 Clemm DL, Macy BL, Santiso-Mere D, McDonnell DP. Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor. The Journal of Steroid Biochemistry and Molecular Biology. 53: 487-95. PMID 7626499 DOI: 10.1016/0960-0760(95)00095-H  0.58
1995 McDonnell DP, Dana SL, Hoener PA, Lieberman BA, Imhof MO, Stein RB. Cellular mechanisms which distinguish between hormone- and antihormone-activated estrogen receptor. Annals of the New York Academy of Sciences. 761: 121-37. PMID 7625716 DOI: 10.1111/J.1749-6632.1995.Tb31374.X  0.555
1995 Norris J, Fan D, Aleman C, Marks JR, Futreal PA, Wiseman RW, Iglehart JD, Deininger PL, McDonnell DP. Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers. The Journal of Biological Chemistry. 270: 22777-82. PMID 7559405 DOI: 10.1074/Jbc.270.39.22777  0.527
1995 McDonnell DP. Unraveling the human progesterone receptor signal transduction pathway. Insights into antiprogestin action Trends in Endocrinology and Metabolism. 6: 133-138. DOI: 10.1016/1043-2760(95)00065-P  0.581
1995 Wen DX, McDonnell DP. Advances in our understanding of ligand-activated nuclear receptors Current Opinion in Biotechnology. 6: 582-589. DOI: 10.1016/0958-1669(95)80096-4  0.493
1994 McDonnell DP, Shahbaz MM, Vegeto E, Goldman ME. The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity. The Journal of Steroid Biochemistry and Molecular Biology. 48: 425-32. PMID 8180103 DOI: 10.1016/0960-0760(94)90190-2  0.538
1994 Tzukerman MT, Esty A, Santiso-Mere D, Danielian P, Parker MG, Stein RB, Pike JW, McDonnell DP. Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Molecular Endocrinology (Baltimore, Md.). 8: 21-30. PMID 8152428 DOI: 10.1210/Mend.8.1.8152428  0.466
1994 McDonnell DP, Clevenger B, Dana S, Santiso-Mere D, Tzukerman MT, Gleeson MA. The mechanism of action of steroid hormones: a new twist to an old tale. Journal of Clinical Pharmacology. 33: 1165-72. PMID 8126251 DOI: 10.1002/J.1552-4604.1993.Tb03916.X  0.54
1994 Crombie DL, Mukherjee R, McDonnell DP, Hayes JS, Wang MW. Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment Journal of Steroid Biochemistry and Molecular Biology. 49: 123-129. PMID 8031708 DOI: 10.1016/0960-0760(94)90002-7  0.487
1994 Mukherjee R, Jow L, Noonan D, McDonnell DP. Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators Journal of Steroid Biochemistry and Molecular Biology. 51: 157-166. PMID 7981125 DOI: 10.1016/0960-0760(94)90089-2  0.4
1994 Wen DX, Xu YF, Mais DE, Goldman ME, McDonnell DP. The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. Molecular and Cellular Biology. 14: 8356-64. PMID 7969170 DOI: 10.1128/Mcb.14.12.8356  0.546
1994 Dana SL, Hoener PA, Wheeler DA, Lawrence CB, McDonnell DP. Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells Molecular Endocrinology. 8: 1193-1207. PMID 7838152 DOI: 10.1210/Mend.8.9.7838152  0.508
1994 Tai PK, Albers MW, McDonnell DP, Chang H, Schreiber SL, Faber LE. Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. Biochemistry. 33: 10666-71. PMID 7521210 DOI: 10.1021/Bi00201A014  0.493
1993 Nawaz Z, Stancel GM, McDonnell DP, Hyder SM. Creation of an active estrogen-responsive element by a single base change in the flanking sequence of a cellular oncogene: A possible mechanism for hormonal carcinogenesis? Molecular Carcinogenesis. 7: 76-82. PMID 8457291 DOI: 10.1002/Mc.2940070204  0.451
1993 Santiso-Mere D, Sone T, Hilliard GM, Pike JW, McDonnell DP. Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems. Molecular Endocrinology (Baltimore, Md.). 7: 833-9. PMID 8413308 DOI: 10.1210/Mend.7.7.8413308  0.443
1993 Poletti A, Conneely OM, McDonnell DP, Schrader WT, O'Malley BW, Weigel NL. Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites. Biochemistry. 32: 9563-9. PMID 8373763 DOI: 10.1021/Bi00088A007  0.459
1993 Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP. Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Molecular Endocrinology (Baltimore, Md.). 7: 1244-55. PMID 8264658 DOI: 10.1210/Mend.7.10.8264658  0.611
1993 McDonnell DP, Vegeto E, Gleeson MA. Nuclear hormone receptors as targets for new drug discovery. Bio/Technology (Nature Publishing Company). 11: 1256-61. PMID 7764187 DOI: 10.1038/Nbt1193-1256  0.521
1992 Pham TA, McDonnell DP, Tsai MJ, O'Malley BW. Modulation of progesterone receptor binding to progesterone response elements by positioned nucleosomes. Biochemistry. 31: 1570-8. PMID 1737013 DOI: 10.1021/Bi00120A039  0.581
1992 Vegeto E, Allan GF, Schrader WT, Tsai MJ, McDonnell DP, O'Malley BW. The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell. 69: 703-13. PMID 1586949 DOI: 10.1016/0092-8674(92)90234-4  0.605
1992 Pham TA, Hwung YP, Santiso-Mere D, McDonnell DP, O'Malley BW. Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast. Molecular Endocrinology (Baltimore, Md.). 6: 1043-50. PMID 1508220 DOI: 10.1210/Mend.6.7.1508220  0.632
1992 Wooge CH, Nilsson GM, Heierson A, McDonnell DP, Katzenellenbogen BS. Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells. Molecular Endocrinology (Baltimore, Md.). 6: 861-9. PMID 1495491 DOI: 10.1210/Mend.6.6.1495491  0.475
1992 McDonnell DP, Vegeto E, O'Malley BW. Identification of a negative regulatory function for steroid receptors Proceedings of the National Academy of Sciences of the United States of America. 89: 10563-10567. PMID 1438251 DOI: 10.1073/Pnas.89.22.10563  0.659
1992 Poletti A, Weigel NL, McDonnell DP, Schrader WT, O'Malley BW, Conneely OM. A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae. Gene. 114: 51-8. PMID 1316867 DOI: 10.1016/0378-1119(92)90706-U  0.6
1991 Liao J, Ozono K, Sone T, McDonnell DP, Pike JW. Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3. Proceedings of the National Academy of Sciences of the United States of America. 87: 9751-5. PMID 2175914 DOI: 10.1073/Pnas.87.24.9751  0.373
1991 Pham TA, Elliston JF, Nawaz Z, Mcdonnell DP, Tsai MJ, O'Malley BW. Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers Proceedings of the National Academy of Sciences of the United States of America. 88: 3125-3129. PMID 2014231 DOI: 10.1073/Pnas.88.8.3125  0.617
1991 McDonnell DP, Nawaz Z, Densmore C, Weigel NL, Pham TA, Clark JH, O'Malley BW. High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae Journal of Steroid Biochemistry and Molecular Biology. 39: 291-297. PMID 1911419 DOI: 10.1016/0960-0760(91)90038-7  0.627
1991 McDonnell DP, Nawaz Z, O'Malley BW. In situ distinction between steroid receptor binding and transactivation at a target gene Molecular and Cellular Biology. 11: 4350-4355. PMID 1875926 DOI: 10.1128/Mcb.11.9.4350  0.639
1990 Hughes M, Malloy P, Kieback D, McDonnell D, Feldman D, Pike JW, O'Malley B. Human vitamin D receptor mutations: identification of molecular defects in hypocalcemic vitamin D resistant rickets. Advances in Experimental Medicine and Biology. 255: 491-503. PMID 2618873 DOI: 10.1007/978-1-4684-5679-0_52  0.42
1989 McDonnell DP, Pike JW, Drutz DJ, Butt TR, O'Malley BW. Reconstitution of the vitamin D-responsive osteocalcin transcription unit in Saccharomyces cerevisiae. Molecular and Cellular Biology. 9: 3517-23. PMID 2552296 DOI: 10.1128/mcb.9.8.3517-3523.1989  0.497
1989 McDonnell DP, Scott RA, Kerner SA, O'Malley BW, Pike JW. Functional domains of the human vitamin D3 receptor regulate osteocalcin gene expression. Molecular Endocrinology (Baltimore, Md.). 3: 635-44. PMID 2542779 DOI: 10.1210/Mend-3-4-635  0.556
1988 Haussler MR, Mangelsdorf DJ, Komm BS, Terpening CM, Yamaoka K, Allegretto EA, Baker AR, Shine J, McDonnell DP, Hughes M. Molecular biology of the vitamin D hormone. Recent Progress in Hormone Research. 44: 263-305. PMID 2851156 DOI: 10.1016/B978-0-12-571144-9.50013-2  0.323
1988 McDonnell DP, Pike JW, O'Malley BW. The vitamin D receptor: a primitive steroid receptor related to thyroid hormone receptor. Journal of Steroid Biochemistry. 30: 41-6. PMID 2838696 DOI: 10.1016/0022-4731(88)90074-X  0.563
1988 Baker AR, McDonnell DP, Hughes M, Crisp TM, Mangelsdorf DJ, Haussler MR, Pike JW, Shine J, O'Malley BW. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proceedings of the National Academy of Sciences of the United States of America. 85: 3294-8. PMID 2835767 DOI: 10.1073/Pnas.85.10.3294  0.518
1987 McDonnell DP, Mangelsdorf DJ, Pike JW, Haussler MR, O'Malley BW. Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science (New York, N.Y.). 235: 1214-7. PMID 3029866 DOI: 10.1126/Science.3029866  0.528
1987 Maxwell BL, McDonnell DP, Conneely OM, Schulz TZ, Greene GL, O'Malley BW. Structural organization and regulation of the chicken estrogen receptor. Molecular Endocrinology (Baltimore, Md.). 1: 25-35. PMID 2901032 DOI: 10.1210/Mend-1-1-25  0.532
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