Donald P. McDonnell - Publications

Affiliations: 
Duke University, Durham, NC 
Area:
Pharmacology, Biochemistry, Molecular Biology
Website:
https://scholars.duke.edu/person/donald.mcdonnell

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wardell SE, Yllanes AP, Chao CA, Bae Y, Andreano KJ, Desautels TK, Heetderks KA, Blitzer JT, Norris JD, McDonnell DP. Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy. Breast Cancer Research and Treatment. PMID 31562570 DOI: 10.1007/s10549-019-05454-y  0.84
2019 Park S, Safi R, Liu X, Baldi R, Liu W, Liu J, Locasale JW, Chang CY, McDonnell DP. Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. Cell Reports. 27: 3587-3601.e4. PMID 31216477 DOI: 10.1016/j.celrep.2019.05.066  0.88
2019 Racioppi L, Nelson ER, Huang W, Mukherjee D, Lawrence SA, Lento W, Masci AM, Jiao Y, Park S, York B, Liu Y, Baek AE, Drewry DH, Zuercher WJ, Bertani FR, ... ... McDonnell DP, et al. CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. Nature Communications. 10: 2450. PMID 31164648 DOI: 10.1038/s41467-019-10424-5  0.88
2019 Coons LA, Burkholder AB, Hewitt SC, McDonnell DP, Korach KS. Decoding the Inversion Symmetry Underlying Transcription Factor DNA-Binding Specificity and Functionality in the Genome. Iscience. 15: 552-591. PMID 31152742 DOI: 10.1016/j.isci.2019.04.006  0.6
2019 Gaillard SL, Andreano KJ, Gay LM, Steiner M, Jorgensen MS, Davidson BA, Havrilesky LJ, Alvarez Secord A, Valea FA, Colon-Otero G, Zajchowski DA, Chang CY, McDonnell DP, Berchuck A, Elvin JA. Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies. Gynecologic Oncology. PMID 30987772 DOI: 10.1016/j.ygyno.2019.04.010  0.88
2019 Wardell SE, Norris JD, McDonnell DP. Targeting mutant estrogen receptors. Elife. 8. PMID 30648967 DOI: 10.7554/eLife.44181  0.84
2018 Johng D, Torga G, Ewing CM, Jin K, Norris JD, McDonnell DP, Isaacs WB. HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer. The Prostate. PMID 30560549 DOI: 10.1002/pros.23747  0.84
2018 Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Giguère V, Bay BH, Vanacker JM, Ghosh S, ... ... McDonnell DP, et al. Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function. Science Signaling. 11. PMID 29945885 DOI: 10.1126/scisignal.aam5855  0.88
2018 Tria GS, Abrams T, Baird J, Burks HE, Firestone B, Gaither LA, Hamann LG, He G, Kirby CA, Kim S, Lombardo F, Macchi KJ, McDonnell DP, Mishina Y, Norris JD, et al. Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer. Journal of Medicinal Chemistry. PMID 29562737 DOI: 10.1021/acs.jmedchem.7b01682  0.84
2018 McDonnell DP, Norris JD, Chang CY. Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery. Cancer Cell. 33: 153-155. PMID 29438688 DOI: 10.1016/j.ccell.2018.01.014  0.88
2017 McLeod AB, Stice JP, Wardell SE, Alley HM, Chang CY, McDonnell DP. Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer. The Prostate. PMID 29243324 DOI: 10.1002/pros.23467  0.88
2017 Baek AE, Yu YA, He S, Wardell SE, Chang CY, Kwon S, Pillai RV, McDowell HB, Thompson JW, Dubois LG, Sullivan PM, Kemper JK, Gunn MD, McDonnell DP, Nelson ER. The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. Nature Communications. 8: 864. PMID 29021522 DOI: 10.1038/s41467-017-00910-z  0.88
2017 Coons LA, Hewitt SC, Burkholder AB, McDonnell DP, Korach KS. DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin. Endocrinology. 158: 3212-3234. PMID 28977594 DOI: 10.1210/en.2017-00468  0.6
2017 Norris JD, Ellison SJ, Baker JG, Stagg DB, Wardell SE, Park S, Alley HM, Baldi RM, Yllanes A, Andreano KJ, Stice JP, Lawrence SA, Eisner JR, Price DK, Moore WR, ... ... McDonnell DP, et al. Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer. The Journal of Clinical Investigation. PMID 28463227 DOI: 10.1172/JCI87328  0.84
2017 Burks HE, Abrams T, Kirby CA, Baird J, Fekete A, Hamann LG, Kim S, Lombardo F, Loo A, Lubicka D, Macchi K, McDonnell DP, Mishina Y, Norris JD, Nunez J, et al. Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer. Journal of Medicinal Chemistry. PMID 28296398 DOI: 10.1021/acs.jmedchem.6b01468  0.84
2017 Stice JP, Wardell SE, Norris JD, Yllanes AP, Alley HM, Haney VO, White HS, Safi R, Winter PS, Cocce KJ, Kishton RJ, Lawrence SA, Strum JC, McDonnell DP. CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC. Molecular Cancer Research : McR. PMID 28209757 DOI: 10.1158/1541-7786.MCR-17-0028  0.84
2017 Christenson JL, Butterfield KT, Spoelstra NS, Norris JD, Josan JS, Pollock JA, McDonnell DP, Katzenellenbogen BS, Katzenellenbogen JA, Richer JK. MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression. Hormones & Cancer. PMID 28194662 DOI: 10.1007/s12672-017-0285-6  0.84
2017 Alfaqih MA, Nelson ER, Liu W, Safi R, Jasper JS, Macias E, Geradts J, Dubois LG, Thompson W, Freeman MR, Chang CY, Chi JT, McDonnell DP, Freedland SJ. CYP27A1 loss dysregulates cholesterol homeostasis in prostate cancer. Cancer Research. PMID 28130224 DOI: 10.1158/0008-5472.CAN-16-2738  0.88
2016 Alexander PB, Chen R, Gong C, Yuan L, Jasper JS, Ding Y, Markowitz GJ, Yang P, Xu X, McDonnell DP, Song E, Wang XF. Distinct receptor tyrosine kinase subsets mediate anti-HER2 drug resistance in breast cancer. The Journal of Biological Chemistry. PMID 27903634 DOI: 10.1074/jbc.M116.754960  0.32
2016 Nelson ER, Li S, Kennedy M, Payne S, Kilibarda K, Groth J, Bowie M, Parilla-Castellar E, Ridder G, Marcom PK, Lyes M, Peterson BL, Cook M, Pizzo SV, McDonnell DP, et al. Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface. Oncotarget. PMID 27768598 DOI: 10.18632/oncotarget.12767  0.32
2016 Pollock JA, Wardell SE, Parent AA, Stagg DB, Ellison SJ, Alley HM, Chao CA, Lawrence SA, Stice JP, Spasojevic I, Baker JG, Kim SH, McDonnell DP, Katzenellenbogen JA, Norris JD. Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer. Nature Chemical Biology. PMID 27501397 DOI: 10.1038/nchembio.2131  1
2016 Park S, Chang CY, Safi R, Liu X, Baldi R, Jasper JS, Anderson GR, Liu T, Rathmell JC, Dewhirst MW, Wood KC, Locasale JW, McDonnell DP. ERRα Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. Cell Reports. PMID 27050525 DOI: 10.1016/j.celrep.2016.03.026  1
2016 Xu X, Zhang Y, Jasper J, Lykken E, Alexander PB, Markowitz GJ, McDonnell DP, Li QJ, Wang XF. MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer. Oncotarget. PMID 26967387 DOI: 10.18632/oncotarget.7953  1
2015 Blessing AM, Ganesan S, Rajapakshe K, Ying Sung Y, Reddy Bollu L, Shi Y, Cheung E, Coarfa C, Chang JT, McDonnell DP, Frigo DE. Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. Molecular Endocrinology (Baltimore, Md.). 29: 1426-39. PMID 26305679 DOI: 10.1210/me.2015-1079  1
2015 Wardell SE, Nelson ER, Chao CA, Alley HM, McDonnell DP. Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader. Endocrine-Related Cancer. 22: 713-24. PMID 26162914 DOI: 10.1530/ERC-15-0287  1
2015 Gustafson JL, Neklesa TK, Cox CS, Roth AG, Buckley DL, Tae HS, Sundberg TB, Stagg DB, Hines J, McDonnell DP, Norris JD, Crews CM. Small-Molecule-Mediated Degradation of the Androgen Receptor Through Hydrophobic Tagging. Angewandte Chemie (International Ed. in English). PMID 26083457 DOI: 10.1002/anie.201503720  1
2015 Lontay B, Bodoor K, Sipos A, Weitzel DH, Loiselle D, Safi R, Zheng D, Devente J, Hickner RC, McDonnell DP, Ribar T, Haystead TA. Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice. The Journal of Biological Chemistry. 290: 17985-98. PMID 26048986 DOI: 10.1074/jbc.M115.658120  1
2015 McDonnell DP, Wardell SE, Norris JD. Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer. Journal of Medicinal Chemistry. 58: 4883-7. PMID 26039356 DOI: 10.1021/acs.jmedchem.5b00760  1
2015 Wardell SE, Ellis MJ, Alley HM, Eisele K, VanArsdale T, Dann SG, Arndt KT, Primeau T, Griffin E, Shao J, Crowder RJ, Lai JP, Norris JD, McDonnell DP, Li S. Efficacy of SERD/SERM Hybrid-CDK4/6 inhibitor combinations in models of endocrine therapy resistant breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 25991817 DOI: 10.1158/1078-0432.CCR-15-0360  1
2015 Allensworth JL, Evans MK, Bertucci F, Aldrich AJ, Festa RA, Finetti P, Ueno NT, Safi R, McDonnell DP, Thiele DJ, Van Laere S, Devi GR. Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer. Molecular Oncology. 9: 1155-68. PMID 25769405 DOI: 10.1016/j.molonc.2015.02.007  1
2015 Choudhary M, Kazmin D, Hu P, Thomas RS, McDonnell DP, Malek G. Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways. The Journal of Pathology. 235: 101-12. PMID 25186463 DOI: 10.1002/path.4433  0.56
2014 Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, Anderson GR, Winter PS, Wang T, Alley HM, Kwong LN, Cooper ZA, Tetzlaff M, Chen PL, Rathmell JC, ... ... McDonnell DP, et al. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Science Signaling. 7: ra121. PMID 25538079 DOI: 10.1126/scisignal.aaa1877  1
2014 Nelson ER, Chang CY, McDonnell DP. Cholesterol and breast cancer pathophysiology. Trends in Endocrinology and Metabolism: Tem. 25: 649-55. PMID 25458418 DOI: 10.1016/j.tem.2014.10.001  0.88
2014 Safi R, Nelson ER, Chitneni SK, Franz KJ, George DJ, Zalutsky MR, McDonnell DP. Copper signaling axis as a target for prostate cancer therapeutics. Cancer Research. 74: 5819-31. PMID 25320179 DOI: 10.1158/0008-5472.CAN-13-3527  1
2014 Wright TM, Wardell SE, Jasper JS, Stice JP, Safi R, Nelson ER, McDonnell DP. Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer. Molecular Cancer Research : McR. 12: 1829-39. PMID 25100862 DOI: 10.1158/1541-7786.MCR-14-0195  1
2014 Wardell SE, Nelson ER, McDonnell DP. From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs). Steroids. 90: 30-8. PMID 25084324 DOI: 10.1016/j.steroids.2014.07.013  1
2014 McDonnell DP, Park S, Goulet MT, Jasper J, Wardell SE, Chang CY, Norris JD, Guyton JR, Nelson ER. Obesity, cholesterol metabolism, and breast cancer pathogenesis. Cancer Research. 74: 4976-82. PMID 25060521 DOI: 10.1158/0008-5472.CAN-14-1756  1
2014 Scholtz EL, Krishnan S, Ball BA, Corbin CJ, Moeller BC, Stanley SD, McDowell KJ, Hughes AL, McDonnell DP, Conley AJ. Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone receptor agonist, 5α-dihydroprogesterone. Proceedings of the National Academy of Sciences of the United States of America. 111: 3365-70. PMID 24550466 DOI: 10.1073/pnas.1318163111  1
2014 Weiser PT, Chang CY, McDonnell DP, Hanson RN. 4,4'-Unsymmetrically substituted 3,3'-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors. Bioorganic & Medicinal Chemistry. 22: 917-26. PMID 24360824 DOI: 10.1016/j.bmc.2013.10.051  1
2014 Shatnawi A, Norris JD, Chaveroux C, Jasper JS, Sherk AB, McDonnell DP, Giguère V. ELF3 is a repressor of androgen receptor action in prostate cancer cells. Oncogene. 33: 862-71. PMID 23435425 DOI: 10.1038/onc.2013.15  0.84
2013 Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, Howe MK, Carver NJ, Pillai RV, Sullivan PM, Sondhi V, Umetani M, Geradts J, McDonnell DP. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science (New York, N.Y.). 342: 1094-8. PMID 24288332 DOI: 10.1126/science.1241908  1
2013 Hu P, Herrmann R, Bednar A, Saloupis P, Dwyer MA, Yang P, Qi X, Thomas RS, Jaffe GJ, Boulton ME, McDonnell DP, Malek G. Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. Proceedings of the National Academy of Sciences of the United States of America. 110: E4069-78. PMID 24106308 DOI: 10.1073/pnas.1307574110  1
2013 Wardell SE, Nelson ER, Chao CA, McDonnell DP. Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2420-31. PMID 23536434 DOI: 10.1158/1078-0432.CCR-12-3771  1
2013 Augello MA, Burd CJ, Birbe R, McNair C, Ertel A, Magee MS, Frigo DE, Wilder-Romans K, Shilkrut M, Han S, Jernigan DL, Dean JL, Fatatis A, McDonnell DP, Visakorpi T, et al. Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes. The Journal of Clinical Investigation. 123: 493-508. PMID 23257359 DOI: 10.1172/JCI64750  1
2013 Shi Y, Han JJ, Tennakoon JB, Mehta FF, Merchant FA, Burns AR, Howe MK, McDonnell DP, Frigo DE. Androgens promote prostate cancer cell growth through induction of autophagy. Molecular Endocrinology (Baltimore, Md.). 27: 280-95. PMID 23250485 DOI: 10.1210/me.2012-1260  1
2013 Nelson ER, Wardell SE, McDonnell DP. The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis. Bone. 53: 42-50. PMID 23168292 DOI: 10.1016/j.bone.2012.11.011  1
2012 Chang CY, McDonnell DP. Molecular pathways: the metabolic regulator estrogen-related receptor α as a therapeutic target in cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 6089-95. PMID 23019305 DOI: 10.1158/1078-0432.CCR-11-3221  1
2012 Weiser PT, Williams AB, Chang CY, McDonnell DP, Hanson RN. 3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding. Bioorganic & Medicinal Chemistry Letters. 22: 6587-90. PMID 23017882 DOI: 10.1016/j.bmcl.2012.09.007  1
2012 Wardell SE, Kazmin D, McDonnell DP. Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes. Molecular Endocrinology (Baltimore, Md.). 26: 1235-48. PMID 22570330 DOI: 10.1210/me.2012-1031  1
2012 Pollock JA, Larrea MD, Jasper JS, McDonnell DP, McCafferty DG. Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners. Acs Chemical Biology. 7: 1221-31. PMID 22533360 DOI: 10.1021/cb300108c  1
2011 Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, et al. Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 108: 18348-53. PMID 22042850 DOI: 10.1073/pnas.1108856108  1
2011 Chang CY, Kazmin D, Jasper JS, Kunder R, Zuercher WJ, McDonnell DP. The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. Cancer Cell. 20: 500-10. PMID 22014575 DOI: 10.1016/j.ccr.2011.08.023  0.88
2011 Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M, Rathmell JC, Khosla S, Gesty-Palmer D, McDonnell DP. The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology. 152: 4691-705. PMID 21933863 DOI: 10.1210/en.2011-1298  0.68
2011 Bodoor K, Lontay B, Safi R, Weitzel DH, Loiselle D, Wei Z, Lengyel S, McDonnell DP, Haystead TA. Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy. The Journal of Biological Chemistry. 286: 31839-51. PMID 21771785 DOI: 10.1074/jbc.M111.270397  1
2011 Wardell SE, Marks JR, McDonnell DP. The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy. Biochemical Pharmacology. 82: 122-30. PMID 21501600 DOI: 10.1016/j.bcp.2011.03.031  1
2011 Dwyer MA, Kazmin D, Hu P, McDonnell DP, Malek G. Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration. Molecular Endocrinology (Baltimore, Md.). 25: 360-72. PMID 21239617 DOI: 10.1210/me.2010-0392  1
2011 Yang J, Chang CY, Safi R, Morgan J, McDonnell DP, Fuller PJ, Clyne CD, Young MJ. Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display. Molecular Endocrinology (Baltimore, Md.). 25: 32-43. PMID 21106883 DOI: 10.1210/me.2010-0193  0.88
2011 Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR, McDonnell DP. CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells. Cancer Research. 71: 528-37. PMID 21098087 DOI: 10.1158/0008-5472.CAN-10-2581  1
2010 Kobayashi S, Stice JP, Kazmin D, Wittmann BM, Kimbrel EA, Edwards DP, Chang CY, McDonnell DP. Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer. Molecular Endocrinology (Baltimore, Md.). 24: 2292-302. PMID 20980435 DOI: 10.1210/me.2010-0289  0.88
2010 McDonnell DP, Wardell SE. The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer. Current Opinion in Pharmacology. 10: 620-8. PMID 20926342 DOI: 10.1016/j.coph.2010.09.007  1
2010 Dwyer MA, Joseph JD, Wade HE, Eaton ML, Kunder RS, Kazmin D, Chang CY, McDonnell DP. WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration. Cancer Research. 70: 9298-308. PMID 20870744 DOI: 10.1158/0008-5472.CAN-10-0226  1
2010 Orr CR, Montie HL, Liu Y, Bolzoni E, Jenkins SC, Wilson EM, Joseph JD, McDonnell DP, Merry DE. An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. The Journal of Biological Chemistry. 285: 35567-77. PMID 20826791 DOI: 10.1074/jbc.M110.146845  1
2010 DuSell CD, Nelson ER, Wang X, Abdo J, Mödder UI, Umetani M, Gesty-Palmer D, Javitt NB, Khosla S, McDonnell DP. The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. Endocrinology. 151: 3675-85. PMID 20501668 DOI: 10.1210/en.2010-0080  0.68
2010 Wade HE, Kobayashi S, Eaton ML, Jansen MS, Lobenhofer EK, Lupien M, Geistlinger TR, Zhu W, Nevins JR, Brown M, Otteson DC, McDonnell DP. Multimodal regulation of E2F1 gene expression by progestins. Molecular and Cellular Biology. 30: 1866-77. PMID 20123965 DOI: 10.1128/MCB.01060-09  1
2010 Muramoto GG, Russell JL, Safi R, Salter AB, Himburg HA, Daher P, Meadows SK, Doan P, Storms RW, Chao NJ, McDonnell DP, Chute JP. Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. Stem Cells (Dayton, Ohio). 28: 523-34. PMID 20054864 DOI: 10.1002/stem.299  1
2010 Hall JM, Barhoover MA, Kazmin D, McDonnell DP, Greenlee WF, Thomas RS. Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation. Molecular Endocrinology (Baltimore, Md.). 24: 359-69. PMID 20032195 DOI: 10.1210/me.2009-0346  1
2010 Alaynick WA, Way JM, Wilson SA, Benson WG, Pei L, Downes M, Yu R, Jonker JW, Holt JA, Rajpal DK, Li H, Stuart J, McPherson R, Remlinger KS, Chang CY, ... McDonnell DP, et al. ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. Molecular Endocrinology (Baltimore, Md.). 24: 299-309. PMID 19965931 DOI: 10.1210/me.2009-0114  1
2010 Chute JP, Ross JR, McDonnell DP. Minireview: Nuclear receptors, hematopoiesis, and stem cells. Molecular Endocrinology (Baltimore, Md.). 24: 1-10. PMID 19934345 DOI: 10.1210/me.2009-0332  1
2010 DuSell CD, Nelson ER, Wittmann BM, Fretz JA, Kazmin D, Thomas RS, Pike JW, McDonnell DP. Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Molecular Endocrinology (Baltimore, Md.). 24: 33-46. PMID 19901195 DOI: 10.1210/me.2009-0339  0.68
2009 Norris JD, Chang CY, Wittmann BM, Kunder RS, Cui H, Fan D, Joseph JD, McDonnell DP. The homeodomain protein HOXB13 regulates the cellular response to androgens. Molecular Cell. 36: 405-16. PMID 19917249 DOI: 10.1016/j.molcel.2009.10.020  1
2009 Joseph JD, Wittmann BM, Dwyer MA, Cui H, Dye DA, McDonnell DP, Norris JD. Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists. Proceedings of the National Academy of Sciences of the United States of America. 106: 12178-83. PMID 19574450 DOI: 10.1073/pnas.0900185106  1
2009 Frigo DE, Sherk AB, Wittmann BM, Norris JD, Wang Q, Joseph JD, Toner AP, Brown M, McDonnell DP. Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro. Molecular Endocrinology (Baltimore, Md.). 23: 1385-96. PMID 19460858 DOI: 10.1210/me.2009-0010  1
2009 Stein RA, Gaillard S, McDonnell DP. Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 114: 106-12. PMID 19429439 DOI: 10.1016/j.jsbmb.2009.02.010  1
2009 Grasfeder LL, Gaillard S, Hammes SR, Ilkayeva O, Newgard CB, Hochberg RB, Dwyer MA, Chang CY, McDonnell DP. Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. Molecular Endocrinology (Baltimore, Md.). 23: 1171-82. PMID 19389810 DOI: 10.1210/me.2009-0024  1
2009 Norris JD, Joseph JD, Sherk AB, Juzumiene D, Turnbull PS, Rafferty SW, Cui H, Anderson E, Fan D, Dye DA, Deng X, Kazmin D, Chang CY, Willson TM, McDonnell DP. Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands. Chemistry & Biology. 16: 452-60. PMID 19389631 DOI: 10.1016/j.chembiol.2009.01.016  1
2009 Clyne CD, Chang CY, Safi R, Fuller PJ, McDonnell DP, Young MJ. Purification and characterization of recombinant human mineralocorticoid receptor. Molecular and Cellular Endocrinology. 302: 81-5. PMID 19114086 DOI: 10.1016/j.mce.2008.11.030  0.88
2009 Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, McDonnell DP. Glucose metabolism as a target of histone deacetylase inhibitors. Molecular Endocrinology (Baltimore, Md.). 23: 388-401. PMID 19106193 DOI: 10.1210/me.2008-0179  1
2009 Collins NH, Lessey EC, DuSell CD, McDonnell DP, Fowler L, Palomino WA, Illera MJ, Yu X, Mo B, Houwing AM, Lessey BA. Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. Biology of Reproduction. 80: 375-83. PMID 18923163 DOI: 10.1095/biolreprod.107.065375  0.68
2008 Stein RA, Chang CY, Kazmin DA, Way J, Schroeder T, Wergin M, Dewhirst MW, McDonnell DP. Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. Cancer Research. 68: 8805-12. PMID 18974123 DOI: 10.1158/0008-5472.CAN-08-1594  0.88
2008 Sherk AB, Frigo DE, Schnackenberg CG, Bray JD, Laping NJ, Trizna W, Hammond M, Patterson JR, Thompson SK, Kazmin D, Norris JD, McDonnell DP. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Research. 68: 7475-83. PMID 18794135 DOI: 10.1158/0008-5472.CAN-08-1047  1
2008 DuSell CD, McDonnell DP. 27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling. Trends in Pharmacological Sciences. 29: 510-4. PMID 18722677 DOI: 10.1016/j.tips.2008.07.003  1
2008 Frigo DE, McDonnell DP. Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation. Molecular Cancer Therapeutics. 7: 659-69. PMID 18347151 DOI: 10.1158/1535-7163.MCT-07-0480  1
2008 DuSell CD, Umetani M, Shaul PW, Mangelsdorf DJ, McDonnell DP. 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Molecular Endocrinology (Baltimore, Md.). 22: 65-77. PMID 17872378 DOI: 10.1210/me.2007-0383  0.68
2007 Hyatt SM, Lockamy EL, Stein RA, McDonnell DP, Miller AB, Orband-Miller LA, Willson TM, Zuercher WJ. On the intractability of estrogen-related receptor alpha as a target for activation by small molecules. Journal of Medicinal Chemistry. 50: 6722-4. PMID 18052088 DOI: 10.1021/jm7012387  1
2007 Wittmann BM, Sherk A, McDonnell DP. Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators. Cancer Research. 67: 9549-60. PMID 17909066 DOI: 10.1158/0008-5472.CAN-07-1590  0.56
2007 Mettu NB, Stanley TB, Dwyer MA, Jansen MS, Allen JE, Hall JM, McDonnell DP. The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors. Molecular Endocrinology (Baltimore, Md.). 21: 2361-77. PMID 17595321 DOI: 10.1210/me.2007-0201  1
2007 Hall JM, McDonnell DP. The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages. Molecular Endocrinology (Baltimore, Md.). 21: 1756-68. PMID 17488971 DOI: 10.1210/me.2007-0060  1
2007 Zella LA, Chang CY, McDonnell DP, Pike JW. The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs. Archives of Biochemistry and Biophysics. 460: 206-12. PMID 17254542 DOI: 10.1016/j.abb.2006.12.016  0.88
2007 Gaillard S, Dwyer MA, McDonnell DP. Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions. Molecular Endocrinology (Baltimore, Md.). 21: 62-76. PMID 17053040 DOI: 10.1210/me.2006-0179  1
2006 Gaillard S, Grasfeder LL, Haeffele CL, Lobenhofer EK, Chu TM, Wolfinger R, Kazmin D, Koves TR, Muoio DM, Chang CY, McDonnell DP. Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs. Molecular Cell. 24: 797-803. PMID 17157261 DOI: 10.1016/j.molcel.2006.10.012  0.88
2006 McDonnell DP. Mechanism-based discovery as an approach to identify the next generation of estrogen receptor modulators. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2432-4. PMID 17142791 DOI: 10.1096/fj.06-1202ufm  1
2006 Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL, Wilson EM, McDonnell DP, Cidlowski JA. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacological Reviews. 58: 782-97. PMID 17132855 DOI: 10.1124/pr.58.4.9  1
2006 Zhang Y, Ma K, Sadana P, Chowdhury F, Gaillard S, Wang F, McDonnell DP, Unterman TG, Elam MB, Park EA. Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. The Journal of Biological Chemistry. 281: 39897-906. PMID 17079227 DOI: 10.1074/jbc.M608657200  1
2006 Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Human PXR forms a tryptophan zipper-mediated homodimer. Biochemistry. 45: 8579-89. PMID 16834332 DOI: 10.1021/bi0602821  1
2006 Kazmin D, Prytkova T, Cook CE, Wolfinger R, Chu TM, Beratan D, Norris JD, Chang CY, McDonnell DP. Linking ligand-induced alterations in androgen receptor structure to differential gene expression: A first step in the rational design of selective androgen receptor modulators Molecular Endocrinology. 20: 1201-1217. PMID 16574741 DOI: 10.1210/me.2005-0309  1
2006 Chao EY, Collins JL, Gaillard S, Miller AB, Wang L, Orband-Miller LA, Nolte RT, McDonnell DP, Willson TM, Zuercher WJ. Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorganic & Medicinal Chemistry Letters. 16: 821-4. PMID 16307879 DOI: 10.1016/j.bmcl.2005.11.030  1
2005 Juzumiene D, Chang CY, Fan D, Hartney T, Norris JD, McDonnell DP. Single-step purification of full-length human androgen receptor. Nuclear Receptor Signaling. 3: e001. PMID 16604169 DOI: 10.1621/nrs.03001  0.88
2005 Hall JM, McDonnell DP. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Molecular Interventions. 5: 343-57. PMID 16394250 DOI: 10.1124/mi.5.6.7  1
2005 Solomon IH, Hager JM, Safi R, McDonnell DP, Redinbo MR, Ortlund EA. Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. Journal of Molecular Biology. 354: 1091-102. PMID 16289203 DOI: 10.1016/j.jmb.2005.10.009  1
2005 Chang CY, Abdo J, Hartney T, McDonnell DP. Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display. Molecular Endocrinology (Baltimore, Md.). 19: 2478-90. PMID 16051662 DOI: 10.1210/me.2005-0072  1
2005 Wu YL, Yang X, Ren Z, McDonnell DP, Norris JD, Willson TM, Greene GL. Structural basis for an unexpected mode of SERM-Mediated ER antagonism Molecular Cell. 18: 413-424. PMID 15893725 DOI: 10.1016/j.molcel.2005.04.014  1
2005 Chang CY, McDonnell DP. Androgen receptor-cofactor interactions as targets for new drug discovery. Trends in Pharmacological Sciences. 26: 225-8. PMID 15860367 DOI: 10.1016/j.tips.2005.03.002  1
2005 Zuercher WJ, Gaillard S, Orband-Miller LA, Chao EY, Shearer BG, Jones DG, Miller AB, Collins JL, McDonnell DP, Willson TM. Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. Journal of Medicinal Chemistry. 48: 3107-9. PMID 15857113 DOI: 10.1021/jm050161j  1
2005 Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nature Structural & Molecular Biology. 12: 357-63. PMID 15723037 DOI: 10.1038/nsmb910  1
2005 Shaffer PL, McDonnell DP, Gewirth DT. Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor. Biochemistry. 44: 2678-85. PMID 15709781 DOI: 10.1021/bi0477182  1
2004 McDonnell DP. The molecular determinants of estrogen receptor pharmacology. Maturitas. 48: S7-12. PMID 15337242 DOI: 10.1016/j.maturitas.2004.03.006  1
2004 Shao W, Keeton EK, McDonnell DP, Brown M. Coactivator AIB1 links estrogen receptor transcriptional activity and stability. Proceedings of the National Academy of Sciences of the United States of America. 101: 11599-604. PMID 15289619 DOI: 10.1073/pnas.0402997101  0.32
2004 Turgeon JL, McDonnell DP, Martin KA, Wise PM. Hormone therapy: physiological complexity belies therapeutic simplicity. Science (New York, N.Y.). 304: 1269-73. PMID 15166356 DOI: 10.1126/science.1096725  1
2004 Jansen MS, Nagel SC, Miranda PJ, Lobenhofer EK, Afshari CA, McDonnell DP. Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. Proceedings of the National Academy of Sciences of the United States of America. 101: 7199-204. PMID 15103026 DOI: 10.1073/pnas.0402014101  0.44
2004 Glass CK, McDonnell DP. The jensen symposium; a tribute to a pioneer in the field of nuclear receptor biology. Molecular Cell. 13: 459-67. PMID 14992717 DOI: 10.1016/S1097-2765(04)00093-0  1
2004 Kurebayashi S, Nakajima T, Kim SC, Chang CY, McDonnell DP, Renaud JP, Jetten AM. Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. Biochemical and Biophysical Research Communications. 315: 919-27. PMID 14985100 DOI: 10.1016/j.bbrc.2004.01.131  0.88
2004 Tirado OM, Selva DM, Toràn N, Suárez-Quian CA, Jansen M, McDonnell DP, Reventós J, Munell F. Increased expression of estrogen receptor beta in pachytene spermatocytes after short-term methoxyacetic acid administration. Journal of Andrology. 25: 84-94. PMID 14662790  0.32
2003 Sathya G, Chang CY, Kazmin D, Cook CE, McDonnell DP. Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion. Cancer Research. 63: 8029-36. PMID 14633736  0.88
2003 Chang CY, Norris JD, Jansen M, Huang HJ, McDonnell DP. Application of random peptide phage display to the study of nuclear hormone receptors. Methods in Enzymology. 364: 118-42. PMID 14631842  0.88
2003 McDonnell DP. Mining the complexities of the estrogen signaling pathways for novel therapeutics. Endocrinology. 144: 4237-40. PMID 14500558 DOI: 10.1210/en.2003-0900  1
2003 Rincavage HL, McDonnell DP, Kuhn CM. Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells. Endocrinology. 144: 2829-35. PMID 12810537 DOI: 10.1210/en.2002-221120  1
2003 Pike JW, Pathrose P, Barmina O, Chang CY, McDonnell DP, Yamamoto H, Shevde NK. Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription. Journal of Cellular Biochemistry. 88: 252-8. PMID 12520523 DOI: 10.1002/jcb.10336  0.88
2002 Sathya G, Jansen MS, Nagel SC, Cook CE, McDonnell DP. Identification and Characterization of Novel Estrogen Receptor-β-Sparing Antiprogestins. Endocrinology. 143: 3071-3082. PMID 28201467 DOI: 10.1210/endo.143.8.8942  0.44
2002 Pathrose P, Barmina O, Chang CY, McDonnell DP, Shevde NK, Pike JW. Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 17: 2196-205. PMID 12469913 DOI: 10.1359/jbmr.2002.17.12.2196  0.88
2002 Huang HJ, Norris JD, McDonnell DP. Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists. Molecular Endocrinology (Baltimore, Md.). 16: 1778-92. PMID 12145334 DOI: 10.1210/me.2002-0089  0.84
2002 Sathya G, Jansen MS, Nagel SC, Cook CE, McDonnell DP. Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins. Endocrinology. 143: 3071-82. PMID 12130573 DOI: 10.1210/endo.143.8.8942  0.44
2002 McDonnell DP, Wijayaratne A, Chang CY, Norris JD. Elucidation of the molecular mechanism of action of selective estrogen receptor modulators. The American Journal of Cardiology. 90: 35F-43F. PMID 12106639  0.88
2002 Li X, Kimbrel EA, Kenan DJ, McDonnell DP. Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation. Molecular Endocrinology (Baltimore, Md.). 16: 1482-91. PMID 12089344 DOI: 10.1210/mend.16.7.0860  0.56
2002 McDonnell DP, Norris JD. Connections and regulation of the human estrogen receptor. Science (New York, N.Y.). 296: 1642-4. PMID 12040178 DOI: 10.1126/science.1071884  1
2002 McDonnell DP, Connor CE, Wijayaratne A, Chang CY, Norris JD. Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators. Recent Progress in Hormone Research. 57: 295-316. PMID 12017549 DOI: 10.1210/rp.57.1.295  1
2002 Li X, McDonnell DP. The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. Molecular and Cellular Biology. 22: 3663-73. PMID 11997503 DOI: 10.1128/MCB.22.11.3663-3673.2002  1
2002 Herrington DM, Howard TD, Brosnihan KB, McDonnell DP, Li X, Hawkins GA, Reboussin DM, Xu J, Zheng SL, Meyers DA, Bleecker ER. Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein. Circulation. 105: 1879-82. PMID 11997270 DOI: 10.1161/01.CIR.0000016173.98826.88  1
2002 Chang CY, McDonnell DP. Evaluation of ligand-dependent changes in AR structure using peptide probes. Molecular Endocrinology (Baltimore, Md.). 16: 647-60. PMID 11923463 DOI: 10.1210/mend.16.4.0818  1
2002 Hall JM, McDonnell DP, Korach KS. Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. Molecular Endocrinology (Baltimore, Md.). 16: 469-86. PMID 11875105 DOI: 10.1210/mend.16.3.0814  1
2002 Norris JD, Fan D, Sherk A, McDonnell DP. A negative coregulator for the human ER. Molecular Endocrinology (Baltimore, Md.). 16: 459-68. PMID 11875103 DOI: 10.1210/mend.16.3.0787  0.84
2001 Wijayaratne AL, McDonnell DP. The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. The Journal of Biological Chemistry. 276: 35684-92. PMID 11473106 DOI: 10.1074/jbc.M101097200  1
2001 Connor CE, Norris JD, Broadwater G, Willson TM, Gottardis MM, Dewhirst MW, McDonnell DP. Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. Cancer Research. 61: 2917-22. PMID 11306468  1
2000 Hall JM, Chang CY, McDonnell DP. Development of peptide antagonists that target estrogen receptor beta-coactivator interactions. Molecular Endocrinology (Baltimore, Md.). 14: 2010-23. PMID 11117531 DOI: 10.1210/mend.14.12.0561  1
2000 Giangrande PH, Kimbrel EA, Edwards DP, McDonnell DP. The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Molecular and Cellular Biology. 20: 3102-15. PMID 10757795 DOI: 10.1128/MCB.20.9.3102-3115.2000  1
1999 Wijayaratne AL, Nagel SC, Paige LA, Christensen DJ, Norris JD, Fowlkes DM, McDonnell DP. Comparative Analyses of Mechanistic Differences Among Antiestrogens1. Endocrinology. 140: 5828-5840. PMID 28200824 DOI: 10.1210/endo.140.12.7164  1
1999 Gaido KW, Leonard LS, Maness SC, Hall JM, McDonnell DP, Saville B, Safe S. Differential Interaction of the Methoxychlor Metabolite 2,2-Bis-(p-Hydroxyphenyl)-1,1,1-Trichloroethane with Estrogen Receptors α and β1. Endocrinology. 140: 5746-5753. PMID 28200584 DOI: 10.1210/endo.140.12.7191  1
1999 Hall JM, McDonnell DP. The Estrogen Receptor β-Isoform (ERβ) of the Human Estrogen Receptor Modulates ERα Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens1. Endocrinology. 140: 5566-5578. PMID 28200448 DOI: 10.1210/endo.140.12.7179  1
1999 Wijayaratne AL, Nagel SC, Paige LA, Christensen DJ, Norris JD, Fowlkes DM, McDonnell DP. Comparative analyses of mechanistic differences among antiestrogens. Endocrinology. 140: 5828-40. PMID 10579349 DOI: 10.1210/endo.140.12.7164  1
1999 Gaido KW, Leonard LS, Maness SC, Hall JM, McDonnell DP, Saville B, Safe S. Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. Endocrinology. 140: 5746-53. PMID 10579340 DOI: 10.1210/endo.140.12.7191  1
1999 Hall JM, McDonnell DP. The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology. 140: 5566-78. PMID 10579320 DOI: 10.1210/endo.140.12.7179  1
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