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Chaitan Khosla - Publications

Affiliations: 
Chemistry Stanford University, Palo Alto, CA 
Area:
Bioorganic and Biophysical Chemistry
Website:
https://chemistry.stanford.edu/people/chaitan-khosla
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Year Citation  Score
2020 Cogan DP, Li X, Sevillano N, Mathews II, Matsui T, Craik CS, Khosla C. Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction. Journal of the American Chemical Society. 142: 14933-14939. PMID 32786753 DOI: 10.1021/Jacs.0C05133  0.36
2020 Gupta A, Ökesli-Armlovich A, Morgens D, Bassik MC, Khosla C. Genome-wide analysis of targets of macrolide antibiotics in mammalian cells. The Journal of Biological Chemistry. PMID 31915244 DOI: 10.1074/Jbc.Ra119.010770  0.32
2019 Zhuang R, Khosla C. Substrates, inhibitors, and probes of mammalian transglutaminase 2. Analytical Biochemistry. 591: 113560. PMID 31874171 DOI: 10.1016/J.Ab.2019.113560  0.392
2019 Nivina A, Yuet KP, Hsu J, Khosla C. Evolution and Diversity of Assembly-Line Polyketide Synthases. Chemical Reviews. PMID 31838842 DOI: 10.1021/Acs.Chemrev.9B00525  0.308
2019 Okesli-Armlovich A, Gupta A, Jimenez M, Auld D, Liu Q, Bassik MC, Khosla C. Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening. Bioorganic & Medicinal Chemistry Letters. PMID 31420268 DOI: 10.1016/J.Bmcl.2019.08.010  0.318
2019 Sankaranarayanan K, Antaris XX, Palanski BA, El Gamal A, Kao CM, Fitch WL, Fischer CR, Khosla C. Tunable Enzymatic Synthesis of the Immunomodulator Lipid IV To Enable Structure-Activity Analysis. Journal of the American Chemical Society. PMID 31184877 DOI: 10.1021/Jacs.9B03066  0.364
2019 Melkonian AV, Weng N, Palanski BA, Khosla C. In Vivo Measurement of Redox-Regulated TG2 Activity. Methods in Molecular Biology (Clifton, N.J.). 1967: 263-274. PMID 31069776 DOI: 10.1007/978-1-4939-9187-7_16  0.327
2019 Klaus M, D'Souza AD, Nivina A, Khosla C, Grininger M. Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains. Acs Chemical Biology. PMID 30682239 DOI: 10.1021/Acschembio.8B01060  0.32
2018 Li X, Sevillano N, La Greca F, Hsu J, Mathews II, Matsui T, Craik CS, Khosla C. Discovery and characterization of a thioesterase-specific monoclonal antibody that recognizes the 6-deoxyerythronolide B synthase. Biochemistry. PMID 30289692 DOI: 10.1021/Acs.Biochem.8B00886  0.341
2018 Li X, Sevillano N, La Greca F, Deis L, Liu YC, Deller MC, Mathews II, Matsui T, Cane DE, Craik CS, Khosla C. Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. Journal of the American Chemical Society. PMID 29762030 DOI: 10.1021/Jacs.8B02100  0.301
2018 Harvey CJB, Tang M, Schlecht U, Horecka J, Fischer CR, Lin HC, Li J, Naughton B, Cherry J, Miranda M, Li YF, Chu AM, Hennessy JR, Vandova GA, Inglis D, ... ... Khosla C, et al. HEx: A heterologous expression platform for the discovery of fungal natural products. Science Advances. 4: eaar5459. PMID 29651464 DOI: 10.1126/Sciadv.Aar5459  0.562
2018 Palanski BA, Khosla C. Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative Mechanism. Biochemistry. PMID 29570977 DOI: 10.1021/Acs.Biochem.8B00204  0.315
2018 Yi MC, Melkonian AV, Ousey JA, Khosla C. Endoplasmic reticulum-resident protein 57 (ERp57) oxidatively inactivates human transglutaminase 2. The Journal of Biological Chemistry. PMID 29305423 DOI: 10.1074/Jbc.Ra117.001382  0.315
2018 Khosla C, Clark DS, Chen W. A tribute to Professor Jay Bailey: A pioneer in biochemical engineering Aiche Journal. 64: 4179-4181. DOI: 10.1002/Aic.16441  0.568
2017 Xie X, Garg A, Khosla C, Cane DE. Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay. Journal of the American Chemical Society. PMID 28682630 DOI: 10.1021/Jacs.7B05502  0.333
2017 Vandova GA, O'Brien RV, Lowry B, Robbins TF, Fischer CR, Davis RW, Khosla C, Harvey CJ, Hillenmeyer ME. Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli. The Journal of Antibiotics. PMID 28400575 DOI: 10.1038/Ja.2017.38  0.303
2017 Xie X, Garg A, Khosla C, Cane DE. Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis. Journal of the American Chemical Society. PMID 28157306 DOI: 10.1021/Jacs.7B00278  0.327
2016 Plugis NM, Palanski BA, Weng CH, Albertelli M, Khosla C. Thioredoxin-1 Selectively Activates Transglutaminase 2 in the Extracellular Matrix of the Small Intestine: Implications for Celiac Disease. The Journal of Biological Chemistry. PMID 28003361 DOI: 10.1074/Jbc.M116.767988  0.314
2016 Robbins T, Kapilivsky J, Cane DE, Khosla C. Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase. Biochemistry. PMID 27441852 DOI: 10.1021/Acs.Biochem.6B00639  0.318
2016 Kuo J, Lynch SR, Liu CW, Xiao X, Khosla C. Partial In Vitro Reconstitution of an Orphan Polyketide Synthase Associated with Clinical Cases of Nocardiosis. Acs Chemical Biology. PMID 27384917 DOI: 10.1021/Acschembio.6B00489  0.354
2016 Robbins T, Liu YC, Cane DE, Khosla C. Structure and mechanism of assembly line polyketide synthases. Current Opinion in Structural Biology. 41: 10-18. PMID 27266330 DOI: 10.1016/J.Sbi.2016.05.009  0.333
2016 Klaus M, Ostrowski MP, Austerjost J, Robbins T, Lowry B, Cane DE, Khosla C. Protein Protein Interactions, not Substrate Recognition, Dominates the Turnover of Chimeric Assembly Line Polyketide Synthases. The Journal of Biological Chemistry. PMID 27246853 DOI: 10.1074/Jbc.M116.730531  0.408
2016 Ostrowski MP, Cane DE, Khosla C. Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases. The Journal of Antibiotics. PMID 27118242 DOI: 10.1038/Ja.2016.41  0.365
2016 Yi MC, Khosla C. Thiol-Disulfide Exchange Reactions in the Mammalian Extracellular Environment. Annual Review of Chemical and Biomolecular Engineering. PMID 27023663 DOI: 10.1146/Annurev-Chembioeng-080615-033553  0.331
2016 Lowry B, Li X, Robbins T, Cane DE, Khosla C. A Turnstile Mechanism for the Controlled Growth of Biosynthetic Intermediates on Assembly Line Polyketide Synthases. Acs Central Science. 2: 14-20. PMID 26878060 DOI: 10.1021/Acscentsci.5B00321  0.336
2016 Xie X, Garg A, Keatinge-Clay AT, Khosla C, Cane DE. The Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues. Biochemistry. PMID 26863427 DOI: 10.1021/Acs.Biochem.6B00024  0.316
2014 Garg A, Xie X, Keatinge-Clay A, Khosla C, Cane DE. Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange. Journal of the American Chemical Society. 136: 10190-3. PMID 25004372 DOI: 10.1021/Ja5056998  0.33
2014 Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C. Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases. Biochemistry. 53: 3796-806. PMID 24871074 DOI: 10.1021/Bi5004316  0.361
2014 Khosla C, Herschlag D, Cane DE, Walsh CT. Assembly line polyketide synthases: mechanistic insights and unsolved problems. Biochemistry. 53: 2875-83. PMID 24779441 DOI: 10.1021/Bi500290T  0.329
2014 Alvarez-Sieiro P, Martin MC, Redruello B, Del Rio B, Ladero V, Palanski BA, Khosla C, Fernandez M, Alvarez MA. Generation of food-grade recombinant Lactobacillus casei delivering Myxococcus xanthus prolyl endopeptidase. Applied Microbiology and Biotechnology. 98: 6689-700. PMID 24752841 DOI: 10.1007/S00253-014-5730-7  0.345
2014 Edwards AL, Matsui T, Weiss TM, Khosla C. Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthase. Journal of Molecular Biology. 426: 2229-45. PMID 24704088 DOI: 10.1016/J.Jmb.2014.03.015  0.379
2014 Kuo J, Khosla C. The initiation ketosynthase (FabH) is the sole rate-limiting enzyme of the fatty acid synthase of Synechococcus sp. PCC 7002. Metabolic Engineering. 22: 53-9. PMID 24395007 DOI: 10.1016/J.Ymben.2013.12.008  0.352
2014 O'Brien RV, Davis RW, Khosla C, Hillenmeyer ME. Computational identification and analysis of orphan assembly-line polyketide synthases. The Journal of Antibiotics. 67: 89-97. PMID 24301183 DOI: 10.1038/Ja.2013.125  0.307
2013 Lowry B, Robbins T, Weng CH, O'Brien RV, Cane DE, Khosla C. In vitro reconstitution and analysis of the 6-deoxyerythronolide B synthase. Journal of the American Chemical Society. 135: 16809-12. PMID 24161212 DOI: 10.1021/Ja409048K  0.348
2013 Xiao X, Yu X, Khosla C. Metabolic flux between unsaturated and saturated fatty acids is controlled by the FabA:FabB ratio in the fully reconstituted fatty acid biosynthetic pathway of Escherichia coli. Biochemistry. 52: 8304-12. PMID 24147979 DOI: 10.1021/Bi401116N  0.312
2013 Walker MC, Thuronyi BW, Charkoudian LK, Lowry B, Khosla C, Chang MC. Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways. Science (New York, N.Y.). 341: 1089-94. PMID 24009388 DOI: 10.1126/Science.1242345  0.692
2013 Walsh CT, O'Brien RV, Khosla C. Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds. Angewandte Chemie (International Ed. in English). 52: 7098-124. PMID 23729217 DOI: 10.1002/Anie.201208344  0.381
2013 Dunn BJ, Khosla C. Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. Journal of the Royal Society, Interface / the Royal Society. 10: 20130297. PMID 23720536 DOI: 10.1098/Rsif.2013.0297  0.364
2013 You YO, Khosla C, Cane DE. Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases. Journal of the American Chemical Society. 135: 7406-9. PMID 23659177 DOI: 10.1021/Ja4014776  0.332
2013 Dunn BJ, Cane DE, Khosla C. Mechanism and specificity of an acyltransferase domain from a modular polyketide synthase. Biochemistry. 52: 1839-41. PMID 23452124 DOI: 10.1021/Bi400185V  0.364
2013 Fitzgerald JT, Charkoudian LK, Watts KR, Khosla C. Analysis and refactoring of the A-74528 biosynthetic pathway. Journal of the American Chemical Society. 135: 3752-5. PMID 23442197 DOI: 10.1021/Ja311579S  0.7
2013 DiRaimondo TR, Plugis NM, Jin X, Khosla C. Selective inhibition of extracellular thioredoxin by asymmetric disulfides. Journal of Medicinal Chemistry. 56: 1301-10. PMID 23327656 DOI: 10.1021/Jm301775S  0.334
2013 Walsh CT, O'Brien RV, Khosla C. Nichtproteinogene Aminosäurebausteine für Peptidgerüste aus nichtribosomalen Peptiden und hybriden Polyketiden Angewandte Chemie. 125: 7238-7265. DOI: 10.1002/Ange.201208344  0.309
2012 Klöck C, Khosla C. Regulation of the activities of the mammalian transglutaminase family of enzymes. Protein Science : a Publication of the Protein Society. 21: 1781-91. PMID 23011841 DOI: 10.1002/Pro.2162  0.37
2012 Harvey CJ, Puglisi JD, Pande VS, Cane DE, Khosla C. Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket. Journal of the American Chemical Society. 134: 12259-65. PMID 22741553 DOI: 10.1021/Ja304682Q  0.363
2012 Yuzawa S, Kapur S, Cane DE, Khosla C. Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. Biochemistry. 51: 3708-10. PMID 22509729 DOI: 10.1021/Bi300399U  0.336
2012 Klöck C, Diraimondo TR, Khosla C. Role of transglutaminase 2 in celiac disease pathogenesis. Seminars in Immunopathology. 34: 513-22. PMID 22437759 DOI: 10.1007/S00281-012-0305-0  0.319
2012 Wang J, Jin X, Liu J, Khosla C, Xia J. Resolving multiple protein-peptide binding events: implication for HLA-DQ2 mediated antigen presentation in celiac disease. Chemistry, An Asian Journal. 7: 992-9. PMID 22411856 DOI: 10.1002/Asia.201101041  0.516
2012 Kapur S, Lowry B, Yuzawa S, Kenthirapalan S, Chen AY, Cane DE, Khosla C. Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation. Proceedings of the National Academy of Sciences of the United States of America. 109: 4110-5. PMID 22371562 DOI: 10.1073/Pnas.1118734109  0.364
2012 Wong FT, Khosla C. Combinatorial biosynthesis of polyketides--a perspective. Current Opinion in Chemical Biology. 16: 117-23. PMID 22342766 DOI: 10.1016/J.Cbpa.2012.01.018  0.315
2012 Dafik L, Albertelli M, Stamnaes J, Sollid LM, Khosla C. Activation and inhibition of transglutaminase 2 in mice. Plos One. 7: e30642. PMID 22319575 DOI: 10.1371/Journal.Pone.0030642  0.316
2012 Bethune MT, Khosla C. Oral enzyme therapy for celiac sprue. Methods in Enzymology. 502: 241-71. PMID 22208988 DOI: 10.1016/B978-0-12-416039-2.00013-6  0.69
2012 Khosla C, Caren R, Kao CM, McDaniel R, Wang SW. Evolutionally guided enzyme design. Biotechnology and Bioengineering. 52: 122-8. PMID 18629858 DOI: 10.1002/(Sici)1097-0290(19961005)52:1<122::Aid-Bit12>3.0.Co;2-Q  0.319
2012 Charkoudian LK, Farrell BP, Khosla C. Natural product inhibitors of glucose-6-phosphate translocase Medchemcomm. 3: 926-931. DOI: 10.1039/C2Md20008B  0.665
2011 Yu X, Liu T, Zhu F, Khosla C. In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 108: 18643-8. PMID 22042840 DOI: 10.1073/Pnas.1110852108  0.32
2011 Fitzgerald JT, Ridley CP, Khosla C. Engineered biosynthesis of the antiparasitic agent frenolicin B and rationally designed analogs in a heterologous host. The Journal of Antibiotics. 64: 759-62. PMID 21934692 DOI: 10.1038/Ja.2011.86  0.368
2011 Jin X, Stamnaes J, Klöck C, DiRaimondo TR, Sollid LM, Khosla C. Activation of extracellular transglutaminase 2 by thioredoxin. The Journal of Biological Chemistry. 286: 37866-73. PMID 21908620 DOI: 10.1074/Jbc.M111.287490  0.308
2011 Szu PH, Govindarajan S, Meehan MJ, Das A, Nguyen DD, Dorrestein PC, Minshull J, Khosla C. Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase. Chemistry & Biology. 18: 1021-31. PMID 21867917 DOI: 10.1016/J.Chembiol.2011.07.015  0.543
2011 Javidpour P, Das A, Khosla C, Tsai SC. Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (HedKR): molecular basis of stereo- and regiospecificities. Biochemistry. 50: 7426-39. PMID 21776967 DOI: 10.1021/Bi2006866  0.551
2011 Wong FT, Jin X, Mathews II, Cane DE, Khosla C. Structure and mechanism of the trans-acting acyltransferase from the disorazole synthase. Biochemistry. 50: 6539-48. PMID 21707057 DOI: 10.1021/Bi200632J  0.371
2011 Charkoudian LK, Liu CW, Capone S, Kapur S, Cane DE, Togni A, Seebach D, Khosla C. Probing the interactions of an acyl carrier protein domain from the 6-deoxyerythronolide B synthase. Protein Science : a Publication of the Protein Society. 20: 1244-55. PMID 21563224 DOI: 10.1002/Pro.652  0.713
2011 Dafik L, Khosla C. Dihydroisoxazole analogs for labeling and visualization of catalytically active transglutaminase 2. Chemistry & Biology. 18: 58-66. PMID 21276939 DOI: 10.1016/J.Chembiol.2010.11.004  0.303
2011 Lee HY, Harvey CJ, Cane DE, Khosla C. Improved precursor-directed biosynthesis in E. coli via directed evolution. The Journal of Antibiotics. 64: 59-64. PMID 21081955 DOI: 10.1038/Ja.2010.129  0.354
2011 Garber M, Siegel M, Khosla C, Voyksner J, Voyksner RD. Quantification of ALV003-Mediated Gluten Degradation Using Mass Spectrometry Gastroenterology. 140: S-642-S-643. DOI: 10.1016/S0016-5085(11)62661-9  0.442
2010 Kapur S, Chen AY, Cane DE, Khosla C. Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. Proceedings of the National Academy of Sciences of the United States of America. 107: 22066-71. PMID 21127271 DOI: 10.1073/Pnas.1014081107  0.361
2010 Charkoudian LK, Fitzgerald JT, Khosla C, Champlin A. In living color: bacterial pigments as an untapped resource in the classroom and beyond. Plos Biology. 8. PMID 20957190 DOI: 10.1371/Journal.Pbio.1000510  0.674
2010 Liu T, Khosla C. Genetic engineering of Escherichia coli for biofuel production. Annual Review of Genetics. 44: 53-69. PMID 20822440 DOI: 10.1146/Annurev-Genet-102209-163440  0.314
2010 Zaleta-Rivera K, Charkoudian LK, Ridley CP, Khosla C. Cloning, sequencing, heterologous expression, and mechanistic analysis of A-74528 biosynthesis. Journal of the American Chemical Society. 132: 9122-8. PMID 20550125 DOI: 10.1021/Ja102519V  0.671
2010 Das A, Szu PH, Fitzgerald JT, Khosla C. Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis. Journal of the American Chemical Society. 132: 8831-3. PMID 20540492 DOI: 10.1021/Ja102517Q  0.578
2010 Khosla C. Thematic minireview series on antibacterial natural products: new tricks for old dogs. The Journal of Biological Chemistry. 285: 27499. PMID 20522550 DOI: 10.1074/Jbc.R110.150417  0.363
2010 Tahanian E, Lord-Dufour S, Das A, Khosla C, Roy R, Annabi B. Inhibition of tubulogenesis and of carcinogen-mediated signaling in brain endothelial cells highlight the antiangiogenic properties of a mumbaistatin analog. Chemical Biology & Drug Design. 75: 481-8. PMID 20486934 DOI: 10.1111/J.1747-0285.2010.00961.X  0.516
2010 Mazumdar K, Alvarez X, Borda JT, Dufour J, Martin E, Bethune MT, Khosla C, Sestak K. Visualization of transepithelial passage of the immunogenic 33-residue peptide from alpha-2 gliadin in gluten-sensitive macaques. Plos One. 5: e10228. PMID 20419103 DOI: 10.1371/Journal.Pone.0010228  0.67
2010 Liu T, Vora H, Khosla C. Quantitative analysis and engineering of fatty acid biosynthesis in E. coli. Metabolic Engineering. 12: 378-86. PMID 20184964 DOI: 10.1016/J.Ymben.2010.02.003  0.784
2010 Sealey-Voyksner JA, Khosla C, Voyksner RD, Jorgenson JW. Novel aspects of quantitation of immunogenic wheat gluten peptides by liquid chromatography-mass spectrometry/mass spectrometry. Journal of Chromatography. A. 1217: 4167-83. PMID 20181349 DOI: 10.1016/J.Chroma.2010.01.067  0.327
2010 Wong FT, Chen AY, Cane DE, Khosla C. Protein-protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthases. Biochemistry. 49: 95-102. PMID 19921859 DOI: 10.1021/Bi901826G  0.351
2009 Das A, Khosla C. In vivo and in vitro analysis of the hedamycin polyketide synthase. Chemistry & Biology. 16: 1197-207. PMID 19942143 DOI: 10.1016/J.Chembiol.2009.11.005  0.553
2009 Valenzano CR, Lawson RJ, Chen AY, Khosla C, Cane DE. The biochemical basis for stereochemical control in polyketide biosynthesis. Journal of the American Chemical Society. 131: 18501-11. PMID 19928853 DOI: 10.1021/Ja908296M  0.313
2009 Bethune MT, Crespo-Bosque M, Bergseng E, Mazumdar K, Doyle L, Sestak K, Sollid LM, Khosla C. Noninflammatory gluten peptide analogs as biomarkers for celiac sprue. Chemistry & Biology. 16: 868-81. PMID 19716477 DOI: 10.1016/j.chembiol.2009.07.009  0.648
2009 Khosla C. Structures and mechanisms of polyketide synthases. The Journal of Organic Chemistry. 74: 6416-20. PMID 19711990 DOI: 10.1021/Jo9012089  0.356
2009 Ehren J, Morón B, Martin E, Bethune MT, Gray GM, Khosla C. A food-grade enzyme preparation with modest gluten detoxification properties. Plos One. 4: e6313. PMID 19621078 DOI: 10.1371/Journal.Pone.0006313  0.805
2009 Das A, Khosla C. Biosynthesis of aromatic polyketides in bacteria. Accounts of Chemical Research. 42: 631-9. PMID 19292437 DOI: 10.1021/Ar8002249  0.604
2009 Bethune MT, Siegel M, Howles-Banerji S, Khosla C. Interferon-gamma released by gluten-stimulated celiac disease-specific intestinal T cells enhances the transepithelial flux of gluten peptides. The Journal of Pharmacology and Experimental Therapeutics. 329: 657-68. PMID 19218531 DOI: 10.1124/Jpet.108.148007  0.723
2009 Lord-Dufour S, Copland IB, Levros LC, Post M, Das A, Khosla C, Galipeau J, Rassart E, Annabi B. Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1alpha: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells. Stem Cells (Dayton, Ohio). 27: 489-97. PMID 19074414 DOI: 10.1634/Stemcells.2008-0855  0.502
2009 Liu CW, Alekseyev VY, Allwardt JR, Bankovich AJ, Cade-Menun BJ, Davis RW, Du LS, Garcia KC, Herschlag D, Khosla C, Kraut DA, Li Q, Null B, Puglisi JD, Sigala PA, et al. The diversity of nuclear magnetic resonance spectroscopy Nato Science For Peace and Security Series B: Physics and Biophysics. 65-81.  0.743
2008 Ehren J, Govindarajan S, Morón B, Minshull J, Khosla C. Protein engineering of improved prolyl endopeptidases for celiac sprue therapy. Protein Engineering, Design & Selection : Peds. 21: 699-707. PMID 18836204 DOI: 10.1093/Protein/Gzn050  0.772
2008 Lu X, Vora H, Khosla C. Overproduction of free fatty acids in E. coli: implications for biodiesel production. Metabolic Engineering. 10: 333-9. PMID 18812230 DOI: 10.1016/J.Ymben.2008.08.006  0.78
2008 Kapur S, Khosla C. Biochemistry: Fit for an enzyme. Nature. 454: 832-3. PMID 18704072 DOI: 10.1038/454832A  0.324
2008 Castonguay R, Valenzano CR, Chen AY, Keatinge-Clay A, Khosla C, Cane DE. Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. Journal of the American Chemical Society. 130: 11598-9. PMID 18693734 DOI: 10.1021/Ja804453P  0.3
2008 Yuan L, Behdad A, Siegel M, Khosla C, Higashikubo R, Rich KM. Tissue transgluaminase 2 expression in meningiomas. Journal of Neuro-Oncology. 90: 125-32. PMID 18587533 DOI: 10.1007/S11060-008-9642-1  0.446
2008 Morón B, Bethune MT, Comino I, Manyani H, Ferragud M, López MC, Cebolla A, Khosla C, Sousa C. Toward the assessment of food toxicity for celiac patients: characterization of monoclonal antibodies to a main immunogenic gluten peptide. Plos One. 3: e2294. PMID 18509534 DOI: 10.1371/Journal.Pone.0002294  0.66
2008 Bethune MT, Khosla C. Parallels between pathogens and gluten peptides in celiac sprue. Plos Pathogens. 4: e34. PMID 18425213 DOI: 10.1371/Journal.Ppat.0040034  0.691
2008 Siegel M, Strnad P, Watts RE, Choi K, Jabri B, Omary MB, Khosla C. Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury. Plos One. 3: e1861. PMID 18365016 DOI: 10.1371/Journal.Pone.0001861  0.488
2008 Bethune MT, Ribka E, Khosla C, Sestak K. Transepithelial transport and enzymatic detoxification of gluten in gluten-sensitive rhesus macaques. Plos One. 3: e1857. PMID 18365012 DOI: 10.1371/Journal.Pone.0001857  0.68
2008 Bethune MT, Borda JT, Ribka E, Liu MX, Phillippi-Falkenstein K, Jandacek RJ, Doxiadis GG, Gray GM, Khosla C, Sestak K. A non-human primate model for gluten sensitivity. Plos One. 3: e1614. PMID 18286171 DOI: 10.1371/Journal.Pone.0001614  0.645
2008 Kapur S, Worthington A, Tang Y, Cane DE, Burkart MD, Khosla C. Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase. Bioorganic & Medicinal Chemistry Letters. 18: 3034-8. PMID 18243693 DOI: 10.1016/J.Bmcl.2008.01.073  0.535
2008 Ehren J, Khosla C. Oral glutenase therapy for celiac sprue Pediatric and Adolescent Medicine. 12: 148-156. DOI: 10.1159/000128996  0.702
2008 Watson P, Ding A, McMillan SA, Smye M, McClean E, Lawther H, Gallagher C, Riedel T, Vora H, Gass J, Khosla C, Gray GM. S1263 Implications of Enzymatic Detoxification of Food Gluten in Coeliac Disease Gastroenterology. 134: A-213. DOI: 10.1016/S0016-5085(08)60985-3  0.753
2008 Siegel M, Strnad P, Watts RE, Choi K, Jabri B, Adler G, Omary B, Khosla C. 1001 Extracellular Transglutaminase 2 Is Catalytically Inactive, But Is Transiently Activated Upon Tissue Injury in the Small Intestine Gastroenterology. 134: A-151. DOI: 10.1016/S0016-5085(08)60701-5  0.453
2008 Schnarr NA, Khosla C. Diversity-oriented Synthesis: Combinatorial Biosynthesis of Polyketides and Nonribosomal Peptides Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 2: 519-536. DOI: 10.1002/9783527619375.ch9b  0.732
2007 Pinkas DM, Strop P, Brunger AT, Khosla C. Transglutaminase 2 undergoes a large conformational change upon activation. Plos Biology. 5: e327. PMID 18092889 DOI: 10.1371/Journal.Pbio.0050327  0.353
2007 Castonguay R, He W, Chen AY, Khosla C, Cane DE. Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase. Journal of the American Chemical Society. 129: 13758-69. PMID 17918944 DOI: 10.1021/Ja0753290  0.349
2007 Alekseyev VY, Liu CW, Cane DE, Puglisi JD, Khosla C. Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase. Protein Science : a Publication of the Protein Society. 16: 2093-107. PMID 17893358 DOI: 10.1110/Ps.073011407  0.785
2007 Tang Y, Chen AY, Kim CY, Cane DE, Khosla C. Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. Chemistry & Biology. 14: 931-43. PMID 17719492 DOI: 10.1016/J.Chembiol.2007.07.012  0.516
2007 Xia J, Bergseng E, Fleckenstein B, Siegel M, Kim CY, Khosla C, Sollid LM. Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease. Bioorganic & Medicinal Chemistry. 15: 6565-73. PMID 17681795 DOI: 10.1016/J.Bmc.2007.07.001  0.625
2007 Gass J, Bethune MT, Siegel M, Spencer A, Khosla C. Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue. Gastroenterology. 133: 472-80. PMID 17681168 DOI: 10.1053/J.Gastro.2007.05.028  0.802
2007 Chen AY, Cane DE, Khosla C. Structure-based dissociation of a type I polyketide synthase module. Chemistry & Biology. 14: 784-92. PMID 17656315 DOI: 10.1016/J.Chembiol.2007.05.015  0.38
2007 Gass J, Vora H, Hofmann AF, Gray GM, Khosla C. Enhancement of dietary protein digestion by conjugated bile acids. Gastroenterology. 133: 16-23. PMID 17631126 DOI: 10.1053/J.Gastro.2007.04.008  0.781
2007 Siegel M, Xia J, Khosla C. Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2. Bioorganic & Medicinal Chemistry. 15: 6253-61. PMID 17590341 DOI: 10.1016/J.Bmc.2007.06.020  0.653
2007 Siegel M, Khosla C. Transglutaminase 2 inhibitors and their therapeutic role in disease states. Pharmacology & Therapeutics. 115: 232-45. PMID 17582505 DOI: 10.1016/J.Pharmthera.2007.05.003  0.528
2007 Lee TS, Das A, Khosla C. Structure-activity relationships of semisynthetic mumbaistatin analogs. Bioorganic & Medicinal Chemistry. 15: 5207-18. PMID 17524653 DOI: 10.1016/J.Bmc.2007.05.019  0.648
2007 Strnad P, Harada M, Siegel M, Terkeltaub RA, Graham RM, Khosla C, Omary MB. Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement. Gastroenterology. 132: 1515-26. PMID 17408647 DOI: 10.1053/J.Gastro.2007.02.020  0.451
2007 Vora H, McIntire J, Kumar P, Deshpande M, Khosla C. A scaleable manufacturing process for pro-EP-B2, a cysteine protease from barley indicated for celiac sprue. Biotechnology and Bioengineering. 98: 177-85. PMID 17385743 DOI: 10.1002/Bit.21423  0.796
2007 Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE. Structure and mechanism of the 6-deoxyerythronolide B synthase. Annual Review of Biochemistry. 76: 195-221. PMID 17328673 DOI: 10.1146/Annurev.Biochem.76.053105.093515  0.798
2007 Tse ML, Watts RE, Khosla C. Substrate tolerance of module 6 of the epothilone synthetase. Biochemistry. 46: 3385-93. PMID 17315981 DOI: 10.1021/Bi0616448  0.358
2007 Lee HY, Khosla C. Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli. Plos Biology. 5: e45. PMID 17298179 DOI: 10.1371/Journal.Pbio.0050045  0.32
2007 Ridley CP, Khosla C. Synthesis and biological activity of novel pyranopyrones derived from engineered aromatic polyketides. Acs Chemical Biology. 2: 104-8. PMID 17256996 DOI: 10.1021/Cb600382J  0.319
2007 Yuan L, Siegel M, Choi K, Khosla C, Miller CR, Jackson EN, Piwnica-Worms D, Rich KM. Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene. 26: 2563-73. PMID 17099729 DOI: 10.1038/Sj.Onc.1210048  0.475
2007 Gass J, Vora H, Hofmann AF, Gray GM, Khosla C. WITHDRAWN: Enhancement of Dietary Protein Digestion by Conjugated Bile Acids Gastroenterology. DOI: 10.1053/J.Gastro.2007.04.030  0.778
2006 Schnarr NA, Khosla C. Trapping transient protein-protein interactions in polyketide biosynthesis. Acs Chemical Biology. 1: 679-80. PMID 17184129 DOI: 10.1021/Cb600451D  0.751
2006 Watts RE, Siegel M, Khosla C. Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles. Journal of Medicinal Chemistry. 49: 7493-501. PMID 17149878 DOI: 10.1021/Jm060839A  0.496
2006 Tang Y, Lee HY, Tang Y, Kim CY, Mathews I, Khosla C. Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2). Biochemistry. 45: 14085-93. PMID 17115703 DOI: 10.1021/Bi061187V  0.611
2006 Rude MA, Khosla C. Production of ansamycin polyketide precursors in Escherichia coli. The Journal of Antibiotics. 59: 464-70. PMID 17080682 DOI: 10.1038/Ja.2006.65  0.788
2006 Tang Y, Kim CY, Mathews II, Cane DE, Khosla C. The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proceedings of the National Academy of Sciences of the United States of America. 103: 11124-9. PMID 16844787 DOI: 10.1073/Pnas.0601924103  0.528
2006 Siegel M, Bethune MT, Gass J, Ehren J, Xia J, Johannsen A, Stuge TB, Gray GM, Lee PP, Khosla C. Rational design of combination enzyme therapy for celiac sprue. Chemistry & Biology. 13: 649-58. PMID 16793522 DOI: 10.1016/J.Chembiol.2006.04.009  0.784
2006 Bethune MT, Strop P, Tang Y, Sollid LM, Khosla C. Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease. Chemistry & Biology. 13: 637-47. PMID 16793521 DOI: 10.1016/J.Chembiol.2006.04.008  0.724
2006 Gass J, Vora H, Bethune MT, Gray GM, Khosla C. Effect of barley endoprotease EP-B2 on gluten digestion in the intact rat. The Journal of Pharmacology and Experimental Therapeutics. 318: 1178-86. PMID 16757540 DOI: 10.1124/Jpet.106.104315  0.78
2006 Hicks LM, Mazur MT, Miller LM, Dorrestein PC, Schnarr NA, Khosla C, Kelleher NL. Investigating nonribosomal peptide and polyketide biosynthesis by direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry. Chembiochem : a European Journal of Chemical Biology. 7: 904-7. PMID 16642537 DOI: 10.1002/Cbic.200500416  0.739
2006 Strnad P, Siegel M, Toivola DM, Choi K, Kosek JC, Khosla C, Omary MB. Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation. Febs Letters. 580: 2351--2357. PMID 16616523 DOI: 10.1016/J.Febslet.2006.03.051  0.458
2006 Chen AY, Schnarr NA, Kim CY, Cane DE, Khosla C. Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase. Journal of the American Chemical Society. 128: 3067-74. PMID 16506788 DOI: 10.1021/Ja058093D  0.779
2006 Xia J, Siegel M, Bergseng E, Sollid LM, Khosla C. Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin. Journal of the American Chemical Society. 128: 1859-67. PMID 16464085 DOI: 10.1021/Ja056423O  0.638
2006 He W, Wu J, Khosla C, Cane DE. Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase. Bioorganic & Medicinal Chemistry Letters. 16: 391-4. PMID 16249083 DOI: 10.1016/J.Bmcl.2005.09.077  0.341
2006 Moffet DA, Khosla C, Cane DE. Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2. Bioorganic & Medicinal Chemistry Letters. 16: 213-6. PMID 16213712 DOI: 10.1016/J.Bmcl.2005.09.017  0.338
2005 Lee TS, Khosla C, Tang Y. Orthogonal protein interactions in spore pigment producing and antibiotic producing polyketide synthases. The Journal of Antibiotics. 58: 663-6. PMID 16392683 DOI: 10.1038/Ja.2005.91  0.662
2005 Wu J, Zaleski TJ, Valenzano C, Khosla C, Cane DE. Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase. Journal of the American Chemical Society. 127: 17393-404. PMID 16332089 DOI: 10.1021/Ja055672+  0.352
2005 Sollid LM, Khosla C. Future therapeutic options for celiac disease. Nature Clinical Practice. Gastroenterology & Hepatology. 2: 140-7. PMID 16265155 DOI: 10.1038/Ncpgasthep0111  0.358
2005 Wu J, He W, Khosla C, Cane DE. Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase. Angewandte Chemie (International Ed. in English). 44: 7557-60. PMID 16247819 DOI: 10.1002/Anie.200502246  0.307
2005 Shan L, Qiao SW, Arentz-Hansen H, Molberg Ø, Gray GM, Sollid LM, Khosla C. Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue. Journal of Proteome Research. 4: 1732-41. PMID 16212427 DOI: 10.1021/Pr050173T  0.606
2005 Pyle GG, Paaso B, Anderson BE, Allen DD, Marti T, Li Q, Siegel M, Khosla C, Gray GM. Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 3: 687-94. PMID 16206502 DOI: 10.1016/S1542-3565(05)00366-6  0.459
2005 Yuan L, Choi K, Khosla C, Zheng X, Higashikubo R, Chicoine MR, Rich KM. Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas. Molecular Cancer Therapeutics. 4: 1293-302. PMID 16170020 DOI: 10.1158/1535-7163.Mct-04-0328  0.306
2005 Gass J, Ehren J, Strohmeier G, Isaacs I, Khosla C. Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from Myxococcus xanthus: implications for Celiac Sprue therapy. Biotechnology and Bioengineering. 92: 674-84. PMID 16136593 DOI: 10.1002/Bit.20643  0.803
2005 Lee TS, Khosla C, Tang Y. Engineered biosynthesis of aklanonic acid analogues. Journal of the American Chemical Society. 127: 12254-62. PMID 16131203 DOI: 10.1021/Ja051429Z  0.68
2005 Schnarr NA, Chen AY, Cane DE, Khosla C. Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry. Biochemistry. 44: 11836-42. PMID 16128585 DOI: 10.1021/Bi0510781  0.775
2005 Schnarr NA, Khosla C. Biological chemistry: just add chlorine. Nature. 436: 1094-5. PMID 16121161 DOI: 10.1038/4361094A  0.753
2005 Hartung IV, Rude MA, Schnarr NA, Hunziker D, Khosla C. Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis. Journal of the American Chemical Society. 127: 11202-3. PMID 16089423 DOI: 10.1021/Ja051430Y  0.792
2005 Choi K, Siegel M, Piper JL, Yuan L, Cho E, Strnad P, Omary B, Rich KM, Khosla C. Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chemistry & Biology. 12: 469-75. PMID 15850984 DOI: 10.1016/J.Chembiol.2005.02.007  0.778
2005 Khosla C, Tang Y. Chemistry. A new route to designer antibiotics. Science (New York, N.Y.). 308: 367-8. PMID 15831747 DOI: 10.1126/Science.1111415  0.541
2005 Bergseng E, Xia J, Kim CY, Khosla C, Sollid LM. Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule. The Journal of Biological Chemistry. 280: 21791-6. PMID 15826953 DOI: 10.1074/Jbc.M501558200  0.492
2005 Xia J, Sollid LM, Khosla C. Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2. Biochemistry. 44: 4442-9. PMID 15766274 DOI: 10.1021/Bi047747C  0.509
2005 Shan L, Mathews II, Khosla C. Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity. Proceedings of the National Academy of Sciences of the United States of America. 102: 3599-604. PMID 15738423 DOI: 10.1073/Pnas.0408286102  0.62
2005 Qiao SW, Piper J, Haraldsen G, Oynebråten I, Fleckenstein B, Molberg O, Khosla C, Sollid LM. Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease. Journal of Immunology (Baltimore, Md. : 1950). 174: 1657-63. PMID 15661929 DOI: 10.4049/Jimmunol.174.3.1657  0.766
2005 Marti T, Molberg Ø, Li Q, Gray GM, Khosla C, Sollid LM. Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: Chemical and immunological characterization Journal of Pharmacology and Experimental Therapeutics. 312: 19-26. PMID 15358813 DOI: 10.1124/Jpet.104.073312  0.344
2004 Wu J, Kinoshita K, Khosla C, Cane DE. Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase. Biochemistry. 43: 16301-10. PMID 15610024 DOI: 10.1021/Bi048147G  0.332
2004 Diacovich L, Mitchell DL, Pham H, Gago G, Melgar MM, Khosla C, Gramajo H, Tsai SC. Crystal structure of the β-subunit of acyl-CoA carboxylase: Structure-based engineering of substrate specificity Biochemistry. 43: 14027-14036. PMID 15518551 DOI: 10.1021/Bi049065V  0.373
2004 Kim CY, Alekseyev VY, Chen AY, Tang Y, Cane DE, Khosla C. Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase. Biochemistry. 43: 13892-8. PMID 15518537 DOI: 10.1021/Bi048418N  0.803
2004 Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S. Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway. Journal of the American Chemical Society. 126: 9924-5. PMID 15303858 DOI: 10.1021/Ja048836F  0.334
2004 Kumar P, Khosla C, Tang Y. Manipulation and analysis of polyketide synthases. Methods in Enzymology. 388: 269-93. PMID 15289078 DOI: 10.1016/S0076-6879(04)88023-6  0.648
2004 Qiao SW, Bergseng E, Molberg Ø, Xia J, Fleckenstein B, Khosla C, Sollid LM. Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion. Journal of Immunology (Baltimore, Md. : 1950). 173: 1757-62. PMID 15265905 DOI: 10.4049/Jimmunol.173.3.1757  0.51
2004 Tang Y, Koppisch AT, Khosla C. The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units. Biochemistry. 43: 9546-55. PMID 15260498 DOI: 10.1021/Bi049157K  0.592
2004 Shan L, Marti T, Sollid LM, Gray GM, Khosla C. Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue. The Biochemical Journal. 383: 311-8. PMID 15245330 DOI: 10.1042/Bj20040907  0.627
2004 Boddy CN, Hotta K, Tse ML, Watts RE, Khosla C. Precursor-directed biosynthesis of epothilone in Escherichia coli. Journal of the American Chemical Society. 126: 7436-7. PMID 15198579 DOI: 10.1021/Ja048108S  0.657
2004 Piper JL, Gray GM, Khosla C. Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo. The Journal of Pharmacology and Experimental Therapeutics. 311: 213-9. PMID 15143130 DOI: 10.1124/Jpet.104.068429  0.748
2004 Kim CY, Quarsten H, Bergseng E, Khosla C, Sollid LM. Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 4175-9. PMID 15020763 DOI: 10.1073/Pnas.0306885101  0.322
2004 Tang Y, Lee TS, Khosla C. Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. Plos Biology. 2: E31. PMID 14966533 DOI: 10.1371/Journal.Pbio.0020031  0.681
2004 Khosla C, Keasling JD. Metabolic engineering for drug discovery and development. Nature Reviews. Drug Discovery. 2: 1019-25. PMID 14654799 DOI: 10.1038/Nrd1256  0.301
2004 Tang Y, Lee TS, Lee HY, Khosla C. Exploring the biosynthetic potential of bimodular aromatic polyketide synthases Tetrahedron. 60: 7659-7671. DOI: 10.1016/J.Tet.2004.05.118  0.685
2004 Rude MA, Khosla C. Engineered biosynthesis of polyketides in heterologous hosts Chemical Engineering Science. 59: 4693-4701. DOI: 10.1016/J.Ces.2004.09.026  0.797
2003 Kumar P, Koppisch AT, Cane DE, Khosla C. Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase. Journal of the American Chemical Society. 125: 14307-12. PMID 14624579 DOI: 10.1021/Ja037429L  0.53
2003 Watanabe K, Khosla C, Stroud RM, Tsai SC. Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. Journal of Molecular Biology. 334: 435-44. PMID 14623185 DOI: 10.1016/J.Jmb.2003.10.021  0.459
2003 Pfeifer BA, Wang CC, Walsh CT, Khosla C. Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Applied and Environmental Microbiology. 69: 6698-702. PMID 14602630 DOI: 10.1128/Aem.69.11.6698-6702.2003  0.675
2003 Admiraal SJ, Khosla C, Walsh CT. A Switch for the transfer of substrate between nonribosomal peptide and polyketide modules of the rifamycin synthetase assembly line. Journal of the American Chemical Society. 125: 13664-5. PMID 14599196 DOI: 10.1021/Ja0379060  0.327
2003 Tang Y, Tsai SC, Khosla C. Polyketide chain length control by chain length factor. Journal of the American Chemical Society. 125: 12708-9. PMID 14558809 DOI: 10.1021/Ja0378759  0.57
2003 Kinoshita K, Pfeifer BA, Khosla C, Cane DE. Precursor-Directed polyketide biosynthesis in Escherichia coli. Bioorganic & Medicinal Chemistry Letters. 13: 3701-4. PMID 14552761 DOI: 10.1016/J.Bmcl.2003.08.008  0.613
2003 Koppisch AT, Khosla C. Structure-based mutagenesis of the malonyl-CoA:acyl carrier protein transacylase from Streptomyces coelicolor. Biochemistry. 42: 11057-64. PMID 12974642 DOI: 10.1021/Bi0349672  0.364
2003 Watanabe K, Wang CC, Boddy CN, Cane DE, Khosla C. Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. The Journal of Biological Chemistry. 278: 42020-6. PMID 12923197 DOI: 10.1074/Jbc.M305339200  0.747
2003 Hu Z, Pfeifer BA, Chao E, Murli S, Kealey J, Carney JR, Ashley G, Khosla C, Hutchinson CR. A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases. Microbiology (Reading, England). 149: 2213-25. PMID 12904561 DOI: 10.1099/Mic.0.26015-0  0.611
2003 Watanabe K, Rude MA, Walsh CT, Khosla C. Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 100: 9774-8. PMID 12888623 DOI: 10.1073/Pnas.1632167100  0.808
2003 Tang Y, Lee TS, Kobayashi S, Khosla C. Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity. Biochemistry. 42: 6588-95. PMID 12767243 DOI: 10.1021/Bi0341962  0.697
2003 Yin Y, Lu H, Khosla C, Cane DE. Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase. Journal of the American Chemical Society. 125: 5671-6. PMID 12733905 DOI: 10.1021/Ja034574Q  0.358
2003 Hans M, Hornung A, Dziarnowski A, Cane DE, Khosla C. Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules. Journal of the American Chemical Society. 125: 5366-74. PMID 12720450 DOI: 10.1021/Ja029539I  0.35
2003 Liou GF, Khosla C. Building-block selectivity of polyketide synthases. Current Opinion in Chemical Biology. 7: 279-84. PMID 12714062 DOI: 10.1016/S1367-5931(03)00016-4  0.791
2003 Li Q, Khosla C, Puglisi JD, Liu CW. Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein. Biochemistry. 42: 4648-57. PMID 12705828 DOI: 10.1021/Bi0274120  0.327
2003 Hausch F, Halttunen T, Mäki M, Khosla C. Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase. Chemistry & Biology. 10: 225-31. PMID 12670536 DOI: 10.1016/S1074-5521(03)00045-0  0.329
2003 Kumar P, Li Q, Cane DE, Khosla C. Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition. Journal of the American Chemical Society. 125: 4097-102. PMID 12670230 DOI: 10.1021/Ja0297537  0.52
2003 Boddy CN, Schneider TL, Hotta K, Walsh CT, Khosla C. Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. Journal of the American Chemical Society. 125: 3428-9. PMID 12643694 DOI: 10.1021/Ja0298646  0.626
2003 Keatinge-Clay AT, Shelat AA, Savage DF, Tsai SC, Miercke LJ, O'Connell JD, Khosla C, Stroud RM. Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure (London, England : 1993). 11: 147-54. PMID 12575934 DOI: 10.1016/S0969-2126(03)00004-2  0.375
2003 Liou GF, Lau J, Cane DE, Khosla C. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. Biochemistry. 42: 200-7. PMID 12515555 DOI: 10.1021/Bi0268100  0.796
2003 Kinoshita K, Khosla C, Cane DE. Precursor-Directed Biosynthesis: Stereospecificity for Branched-Chain Diketides of the β-Ketoacyl-ACP Synthase Domain 2 of 6-Deoxyerythronolide B Synthase Helvetica Chimica Acta. 86: 3889-3907. DOI: 10.1002/Hlca.200390327  0.311
2002 Pan H, Tsai Sc, Meadows ES, Miercke LJ, Keatinge-Clay AT, O'Connell J, Khosla C, Stroud RM. Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure (London, England : 1993). 10: 1559-68. PMID 12429097 DOI: 10.1016/S0969-2126(02)00889-4  0.305
2002 Tsai SC, Lu H, Cane DE, Khosla C, Stroud RM. Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry. 41: 12598-606. PMID 12379102 DOI: 10.1021/Bi0260177  0.322
2002 Lu H, Tsai SC, Khosla C, Cane DE. Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. Biochemistry. 41: 12590-7. PMID 12379101 DOI: 10.1021/Bi026006D  0.355
2002 Shan L, Molberg Ø, Parrot I, Hausch F, Filiz F, Gray GM, Sollid LM, Khosla C. Structural basis for gluten intolerance in celiac sprue. Science (New York, N.Y.). 297: 2275-9. PMID 12351792 DOI: 10.1126/Science.1074129  0.614
2002 Parrot I, Huang PC, Khosla C. Circular dichroism and nuclear magnetic resonance spectroscopic analysis of immunogenic gluten peptides and their analogs. The Journal of Biological Chemistry. 277: 45572-8. PMID 12324465 DOI: 10.1074/Jbc.M207606200  0.369
2002 Hausch F, Shan L, Santiago NA, Gray GM, Khosla C. Intestinal digestive resistance of immunodominant gliadin peptides. American Journal of Physiology. Gastrointestinal and Liver Physiology. 283: G996-G1003. PMID 12223360 DOI: 10.1152/Ajpgi.00136.2002  0.608
2002 Pfeifer B, Hu Z, Licari P, Khosla C. Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B. Applied and Environmental Microbiology. 68: 3287-92. PMID 12089005 DOI: 10.1128/Aem.68.7.3287-3292.2002  0.607
2002 Diacovich L, Peirú S, Kurth D, Rodríguez E, Podestá F, Khosla C, Gramajo H. Kinetic and structural analysis of a new group of Acyl-CoA carboxylases found in Streptomyces coelicolor A3(2). Journal of Biological Chemistry. 277: 31228-31236. PMID 12048195 DOI: 10.1074/Jbc.M203263200  0.314
2002 Admiraal SJ, Khosla C, Walsh CT. The loading and initial elongation modules of rifamycin synthetase collaborate to produce mixed aryl ketide products. Biochemistry. 41: 5313-24. PMID 11955082 DOI: 10.1021/Bi0200312  0.334
2002 Dayem LC, Carney JR, Santi DV, Pfeifer BA, Khosla C, Kealey JT. Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Biochemistry. 41: 5193-201. PMID 11955068 DOI: 10.1021/Bi015593K  0.614
2002 Wu N, Cane DE, Khosla C. Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases. Biochemistry. 41: 5056-66. PMID 11939803 DOI: 10.1021/Bi012086U  0.594
2002 Cane DE, Kudo F, Kinoshita K, Khosla C. Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides. Chemistry & Biology. 9: 131-42. PMID 11841945 DOI: 10.1016/S1074-5521(02)00089-3  0.339
2002 McDaniel R, Licari P, Khosla C. Process development and metabolic engineering for the overproduction of natural and unnatural polyketides. Advances in Biochemical Engineering/Biotechnology. 73: 31-52. PMID 11816811 DOI: 10.1007/3-540-45300-8_3  0.312
2002 Piper JL, Gray GM, Khosla C. High selectivity of human tissue transglutaminase for immunoactive gliadin peptides: implications for celiac sprue. Biochemistry. 41: 386-93. PMID 11772038 DOI: 10.1021/Bi011715X  0.779
2001 Tsai SC, Miercke LJ, Krucinski J, Gokhale R, Chen JC, Foster PG, Cane DE, Khosla C, Stroud RM. Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. Proceedings of the National Academy of Sciences of the United States of America. 98: 14808-13. PMID 11752428 DOI: 10.1073/Pnas.011399198  0.363
2001 Meadows ES, Khosla C. In vitro reconstitution and analysis of the chain initiating enzymes of the R1128 polyketide synthase Biochemistry. 40: 14855-14861. PMID 11732905 DOI: 10.1021/Bi0113723  0.378
2001 Dreier J, Li Q, Khosla C. Malonyl-CoA:ACP transacylase from Streptomyces coelicolor has two alternative catalytically active nucleophiles. Biochemistry. 40: 12407-12411. PMID 11591161 DOI: 10.1021/Bi011108+  0.339
2001 Lombó F, Pfeifer B, Leaf T, Ou S, Kim YS, Cane DE, Licari P, Khosla C. Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering. Biotechnology Progress. 17: 612-7. PMID 11485419 DOI: 10.1021/Bp010045J  0.631
2001 Kinoshita K, Williard PG, Khosla C, Cane DE. Precursor-directed biosynthesis of 16-membered macrolides by the erythromycin polyketide synthase. Journal of the American Chemical Society. 123: 2495-502. PMID 11456917 DOI: 10.1021/Ja004139L  0.318
2001 Chiu HT, Hubbard BK, Shah AN, Eide J, Fredenburg RA, Walsh CT, Khosla C. Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 98: 8548-53. PMID 11447274 DOI: 10.1073/Pnas.151246498  0.387
2001 Wu N, Tsuji SY, Cane DE, Khosla C. Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules. Journal of the American Chemical Society. 123: 6465-74. PMID 11439032 DOI: 10.1021/Ja010219T  0.792
2001 Salomon AR, Zhang Y, Seto H, Khosla C. Structure-activity relationships within a family of selectively cytotoxic macrolide natural products. Organic Letters. 3: 57-9. PMID 11429871 DOI: 10.1021/Ol006767D  0.663
2001 Yin Y, Gokhale R, Khosla C, Cane DE. Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase. Bioorganic & Medicinal Chemistry Letters. 11: 1477-9. PMID 11412964 DOI: 10.1016/S0960-894X(00)00529-1  0.326
2001 Pohl NL, Hans M, Lee HY, Kim YS, Cane DE, Khosla C. Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors. Journal of the American Chemical Society. 123: 5822-3. PMID 11403625 DOI: 10.1021/Ja0028368  0.333
2001 Admiraal SJ, Walsh CT, Khosla C. The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates. Biochemistry. 40: 6116-23. PMID 11352749 DOI: 10.1021/Bi010080Z  0.321
2001 Tsuji SY, Cane DE, Khosla C. Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. Biochemistry. 40: 2326-31. PMID 11327852 DOI: 10.1021/Bi002463N  0.802
2001 Tsuji SY, Wu N, Khosla C. Intermodular communication in polyketide synthases: comparing the role of protein-protein interactions to those in other multidomain proteins. Biochemistry. 40: 2317-25. PMID 11327851 DOI: 10.1021/Bi002462V  0.787
2001 Pfeifer BA, Khosla C. Biosynthesis of polyketides in heterologous hosts. Microbiology and Molecular Biology Reviews : Mmbr. 65: 106-18. PMID 11238987 DOI: 10.1128/Mmbr.65.1.106-118.2001  0.6
2001 Pfeifer BA, Admiraal SJ, Gramajo H, Cane DE, Khosla C. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science (New York, N.Y.). 291: 1790-2. PMID 11230695 DOI: 10.1126/Science.1058092  0.611
2001 Salomon AR, Voehringer DW, Herzenberg LA, Khosla C. Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chemistry & Biology. 8: 71-80. PMID 11182320 DOI: 10.1016/S1074-5521(00)00057-0  0.647
2000 Salomon AR, Voehringer DW, Herzenberg LA, Khosla C. Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Proceedings of the National Academy of Sciences of the United States of America. 97: 14766-71. PMID 11121076 DOI: 10.1073/Pnas.97.26.14766  0.641
2000 Lau J, Cane DE, Khosla C. Substrate specificity of the loading didomain of the erythromycin polyketide synthase. Biochemistry. 39: 10514-20. PMID 10956042 DOI: 10.1021/Bi000602V  0.6
2000 Marti T, Hu Z, Pohl NL, Shah AN, Khosla C. Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism. The Journal of Biological Chemistry. 275: 33443-8. PMID 10931852 DOI: 10.1074/Jbc.M006766200  0.319
2000 Julien B, Shah S, Ziermann R, Goldman R, Katz L, Khosla C. Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum. Gene. 249: 153-60. PMID 10831849 DOI: 10.1016/S0378-1119(00)00149-9  0.314
2000 Dreier J, Khosla C. Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-ketoacyl synthase-chain length factor heterodimer. Biochemistry. 39: 2088-2095. PMID 10684659 DOI: 10.1021/Bi992121L  0.343
2000 Gokhale RS, Khosla C. Role of linkers in communication between protein modules. Current Opinion in Chemical Biology. 4: 22-7. PMID 10679375 DOI: 10.1016/S1367-5931(99)00046-0  0.334
2000 Tang L, Shah S, Chung L, Carney J, Katz L, Khosla C, Julien B. Cloning and heterologous expression of the epothilone gene cluster. Science (New York, N.Y.). 287: 640-2. PMID 10649995 DOI: 10.1126/Science.287.5453.640  0.322
2000 Wu N, Kudo F, Cane DE, Khosla C. Analysis of the molecular recognition features of individual modules derived from the erythromycin polyketide synthase Journal of the American Chemical Society. 122: X. DOI: 10.1021/Ja000023D  0.574
2000 Burson KK, Khosla C. Dissecting the Chain Length Specificity in Bacterial Aromatic Polyketide Synthases using Chimeric Genes Tetrahedron. 56: 9401-9408. DOI: 10.1016/S0040-4020(00)00824-3  0.332
1999 Richardson MT, Pohl NL, Kealey JT, Khosla C. Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase. Metabolic Engineering. 1: 180-7. PMID 10935930 DOI: 10.1006/Mben.1999.0113  0.371
1999 Khosla C, Gokhale RS, Jacobsen JR, Cane DE. Tolerance and specificity of polyketide synthases. Annual Review of Biochemistry. 68: 219-53. PMID 10872449 DOI: 10.1146/Annurev.Biochem.68.1.219  0.365
1999 Hu Z, Hunziker D, Hutchinson CR, Khosla C. A host-vector system for analysis and manipulation of rifamycin polyketide biosynthesis in Amycolatopsis mediterranei. Microbiology (Reading, England). 145: 2335-41. PMID 10517586 DOI: 10.1099/00221287-145-9-2335  0.334
1999 Zawada RJ, Khosla C. Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase Chemistry & Biology. 6: 607-615. PMID 10467128 DOI: 10.1016/S1074-5521(99)80112-4  0.369
1999 Dreier J, Shah AN, Khosla C. Kinetic analysis of the actinorhodin aromatic polyketide synthase. Journal of Biological Chemistry. 274: 25108-25112. PMID 10455191 DOI: 10.1074/Jbc.274.35.25108  0.368
1999 Gokhale RS, Tsuji SY, Cane DE, Khosla C. Dissecting and exploiting intermodular communication in polyketide synthases. Science (New York, N.Y.). 284: 482-5. PMID 10205055 DOI: 10.1126/Science.284.5413.482  0.8
1999 Gokhale RS, Hunziker D, Cane DE, Khosla C. Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase. Chemistry & Biology. 6: 117-25. PMID 10021418 DOI: 10.1016/S1074-5521(99)80008-8  0.34
1999 Lau J, Fu H, Cane DE, Khosla C. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. Biochemistry. 38: 1643-51. PMID 9931032 DOI: 10.1021/Bi9820311  0.612
1999 Hunziker D, Wu N, Kenoshita K, Cane DE, Khosla C. Precursor directed biosynthesis of novel 6-deoxyerythronolide B analogs containing non-natural oxygen substituents and reactive functionalities Tetrahedron Letters. 40: 635-638. DOI: 10.1016/S0040-4039(98)02507-6  0.527
1998 Jacobsen JR, Keatinge-Clay AT, Cane DE, Khosla C. Precursor-directed biosynthesis of 12-ethyl erythromycin. Bioorganic & Medicinal Chemistry. 6: 1171-7. PMID 9784859 DOI: 10.1016/S0968-0896(98)00081-9  0.361
1998 Cane DE, Walsh CT, Khosla C. Harnessing the biosynthetic code: combinations, permutations, and mutations. Science (New York, N.Y.). 282: 63-8. PMID 9756477 DOI: 10.1126/Science.282.5386.63  0.394
1998 Jacobsen JR, Cane DE, Khosla C. Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis. Biochemistry. 37: 4928-34. PMID 9538011 DOI: 10.1021/Bi9729920  0.399
1998 Carreras CW, Khosla C. Purification And In Vitro Reconstitution Of The Essential Protein Components Of An Aromatic Polyketide Synthase Biochemistry. 37: 2084-2088. PMID 9518007 DOI: 10.1021/Bi972919+  0.381
1998 Gokhale RS, Lau J, Cane DE, Khosla C. Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase. Biochemistry. 37: 2524-8. PMID 9485401 DOI: 10.1021/Bi971887N  0.619
1998 Yu TW, Shen Y, McDaniel R, Floss HG, Khosla C, Hopwood DA, Moore BS. Engineered biosynthesis of novel polyketides from Streptomyces spore pigment polyketide synthases Journal of the American Chemical Society. 120: 7749-7759. DOI: 10.1021/Ja9803658  0.314
1997 Chuck JA, McPherson M, Huang H, Jacobsen JR, Khosla C, Cane DE. Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase. Chemistry & Biology. 4: 757-66. PMID 9375254 DOI: 10.1016/S1074-5521(97)90314-8  0.407
1997 McDaniel R, Kao CM, Hwang SJ, Khosla C. Engineered intermodular and intramodular polyketide synthase fusions. Chemistry & Biology. 4: 667-74. PMID 9331407 DOI: 10.1016/S1074-5521(97)90222-2  0.38
1997 Carreras CW, Gehring AM, Walsh CT, Khosla C. Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase. Biochemistry. 36: 11757-61. PMID 9305965 DOI: 10.1021/Bi971350+  0.398
1997 Fu H, Khosla C. Antibiotic activity of polyketide products derived from combinatorial biosynthesis: implications for directed evolution. Molecular Diversity. 1: 121-4. PMID 9237201 DOI: 10.1007/Bf01721327  0.352
1997 Jacobsen JR, Hutchinson CR, Cane DE, Khosla C. Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. Science (New York, N.Y.). 277: 367-9. PMID 9219693 DOI: 10.1126/Science.277.5324.367  0.377
1997 Zawada RJX, Khosla C. Domain analysis of the molecular recognition features of aromatic polyketide synthase subunits. Journal of Biological Chemistry. 272: 16184-16188. PMID 9195917 DOI: 10.1074/Jbc.272.26.16184  0.372
1997 Pieper R, Gokhale RS, Luo G, Cane DE, Khosla C. Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase. Biochemistry. 36: 1846-51. PMID 9048569 DOI: 10.1021/Bi962324Z  0.411
1997 Kramer PJ, Zawada RJX, McDaniel R, Hutchinson CR, Hopwood DA, Khosla C. Rational design and engineered biosynthesis of a novel 18-carbon aromatic polyketide Journal of the American Chemical Society. 119: 635-639. DOI: 10.1021/Ja962888Q  0.31
1997 Carreras CW, Pieper R, Khosla C. The chemistry and biology of fatty acid, polyketide, and nonribosomal peptide biosynthesis Topics in Current Chemistry. 188: 85-126. DOI: 10.1007/Bfb0119235  0.373
1996 Alvarez MA, Fu H, Khosla C, Hopwood DA, Bailey JE. Engineered biosynthesis of novel polyketides: properties of the whiE aromatase/cyclase. Nature Biotechnology. 14: 335-8. PMID 9630896 DOI: 10.1038/Nbt0396-335  0.515
1996 Tsukamoto N, Chuck JA, Luo G, Kao CM, Khosla C, Cane DE. 6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2. Biochemistry. 35: 15244-8. PMID 8952473 DOI: 10.1021/Bi961972F  0.375
1996 Lambalot RH, Gehring AM, Flugel RS, Zuber P, LaCelle M, Marahiel MA, Reid R, Khosla C, Walsh CT. A new enzyme superfamily - the phosphopantetheinyl transferases. Chemistry & Biology. 3: 923-36. PMID 8939709 DOI: 10.1016/S1074-5521(96)90181-7  0.387
1996 Bedford D, Jacobsen JR, Luo G, Cane DE, Khosla C. A functional chimeric modular polyketide synthase generated via domain replacement Chemistry and Biology. 3: 827-831. PMID 8939701 DOI: 10.1016/S1074-5521(96)90068-X  0.368
1996 Luo G, Pieper R, Rosa A, Khosla C, Cane DE. Erythromycin biosynthesis: Exploiting the catalytic versatility of the modular polyketide synthase Bioorganic and Medicinal Chemistry. 4: 995-999. PMID 8831969 DOI: 10.1016/0968-0896(96)00096-X  0.315
1996 Kao CM, Pieper R, Cane DE, Khosla C. Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase Biochemistry. 35: 12363-12368. PMID 8823171 DOI: 10.1021/Bi9616312  0.37
1996 Khosla C, Zawada RJ. Generation of polyketide libraries via combinatorial biosynthesis. Trends in Biotechnology. 14: 335-41. PMID 8818287 DOI: 10.1016/0167-7799(96)10046-9  0.345
1996 Blanco G, Fu H, Mendez C, Khosla C, Salas JA. Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents Chemistry & Biology. 3: 193-196. PMID 8807845 DOI: 10.1016/S1074-5521(96)90262-8  0.347
1996 Pieper R, Ebert-Khosla S, Cane D, Khosla C. Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates. Biochemistry. 35: 2054-60. PMID 8652546 DOI: 10.1021/Bi952860B  0.353
1996 Fu H, Alvarez MA, Khosla C, Bailey JE. Engineered biosynthesis of novel polyketides: regiospecific methylation of an unnatural substrate by the tcmO O-methyltransferase. Biochemistry. 35: 6527-32. PMID 8639600 DOI: 10.1021/Bi952957Y  0.524
1996 Pieper R, Kao C, Khosla C, Luo G, Cane DE. Specificity and versatility in erythromycin biosynthesis Chemical Society Reviews. 25: 297-302. DOI: 10.1039/Cs9962500297  0.317
1995 Tsoi CJ, Khosla C. Combinatorial biosynthesis of ‘unnatural’ natural products: the polyketide example Chemistry & Biology. 2: 355-362. PMID 9383437 DOI: 10.1016/1074-5521(95)90214-7  0.328
1995 McDaniel R, Ebert-Khosla S, Hopwood DA, Khosla C. Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits. Nature. 375: 549-54. PMID 7791871 DOI: 10.1038/375549A0  0.338
1995 Bedford DJ, Schweizer E, Hopwood DA, Khosla C. Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2). Journal of Bacteriology. 177: 4544-8. PMID 7635840 DOI: 10.1128/Jb.177.15.4544-4548.1995  0.305
1995 Pieper R, Luo G, Cane DE, Khosla C. Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases Nature. 378: 263-266. PMID 7477343 DOI: 10.1038/378263A0  0.392
1995 Pieper R, Luo G, Cane DE, Khosla C. Remarkably broad substrate specificity of a modular polyketide synthase in a cell-free system Journal of the American Chemical Society. 117: 11373-11374. DOI: 10.1021/Ja00150A049  0.303
1994 Fu H, Hopwood DA, Khosla C. Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precursor Chemistry & Biology. 1: 205-210. PMID 9383392 DOI: 10.1016/1074-5521(94)90012-4  0.346
1994 Kao CM, Katz L, Khosla C. Engineered biosynthesis of a complete macrolactone in a heterologous host. Science (New York, N.Y.). 265: 509-12. PMID 8036492 DOI: 10.1126/Science.8036492  0.37
1994 McDaniel R, Ebert-Khosla S, Fu H, Hopwood DA, Khosla C. Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase Proceedings of the National Academy of Sciences of the United States of America. 91: 11542-11546. PMID 7972098 DOI: 10.1073/Pnas.91.24.11542  0.41
1994 Caren R, Mørkeberg R, Khosla C. Efficient sampling of protein sequence space for multiple mutants. Bio/Technology (Nature Publishing Company). 12: 517-20. PMID 7764711 DOI: 10.1038/Nbt0594-517  0.316
1994 McDaniel R, Ebert-Khosla S, Hopwood DA, Khosla C. Engineered Biosynthesis of Novel Polyketides: actVII and actIV Genes Encode Aromatase and Cyclase Enzymes, Respectively Journal of the American Chemical Society. 116: 10855-10859. DOI: 10.1021/Ja00103A001  0.322
1994 Fu H, Ebert-Khosla S, Hopwood DA, Khosla C. Engineered Biosynthesis of Novel Polyketides: Dissection of the Catalytic Specificity of the act Ketoreductase Journal of the American Chemical Society. 116: 4166-4170. DOI: 10.1021/Ja00089A003  0.311
1993 Khosla C, McDaniel R, Ebert-Khosla S, Torres R, Sherman DH, Bibb MJ, Hopwood DA. Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins. Journal of Bacteriology. 175: 2197-204. PMID 8468280 DOI: 10.1128/Jb.175.8.2197-2204.1993  0.359
1993 McDaniel R, Ebert-Khosla S, Hopwood DA, Khosla C. Engineered biosynthesis of novel polyketides: manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificities Journal of the American Chemical Society. 115: 11671-11675. DOI: 10.1021/Ja00078A002  0.334
1990 Bailey JE, Birnbaum S, Galazzo JL, Khosla C, Shanks JV. Strategies and challenges in metabolic engineering. Annals of the New York Academy of Sciences. 589: 1-15. PMID 2192652 DOI: 10.1111/J.1749-6632.1990.Tb24230.X  0.653
1990 Khosla C, Curtis JE, Bydalek P, Swartz JR, Bailey JE. Expression of recombinant proteins in Escherichia coli using an oxygen-responsive promoter. Bio/Technology (Nature Publishing Company). 8: 554-8. PMID 1367436 DOI: 10.1038/Nbt0690-554  0.483
1990 Khosla C, Curtis JE, DeModena J, Rinas U, Bailey JE. Expression of intracellular hemoglobin improves protein synthesis in oxygen-limited Escherichia coli. Bio/Technology (Nature Publishing Company). 8: 849-53. PMID 1366796 DOI: 10.1038/Nbt0990-849  0.519
1989 Hughes DE, Curtis JE, Khosla C, Bailey JE. A new oxygen-regulated promoter for the expression of proteins in Escherichia coli. Biotechniques. 7: 1026-8. PMID 2698665  0.392
1989 Khosla C, Bailey JE. Evidence for partial export of Vitreoscilla hemoglobin into the periplasmic space in Escherichia coli. Implications for protein function. Journal of Molecular Biology. 210: 79-89. PMID 2685332 DOI: 10.1016/0022-2836(89)90292-1  0.508
1989 Khosla C, Bailey JE. Characterization of the oxygen-dependent promoter of the Vitreoscilla hemoglobin gene in Escherichia coli. Journal of Bacteriology. 171: 5995-6004. PMID 2681149 DOI: 10.1128/Jb.171.11.5995-6004.1989  0.461
1988 Khosla C, Bailey JE. Heterologous expression of a bacterial haemoglobin improves the growth properties of recombinant Escherichia coli. Nature. 331: 633-5. PMID 3277067 DOI: 10.1038/331633A0  0.471
1988 Khosla C, Bailey JE. The Vitreoscilla hemoglobin gene: molecular cloning, nucleotide sequence and genetic expression in Escherichia coli. Molecular & General Genetics : Mgg. 214: 158-61. PMID 3067078 DOI: 10.1007/Bf00340195  0.478
Low-probability matches (unlikely to be authored by this person)
2008 Ridley CP, Lee HY, Khosla C. Evolution of polyketide synthases in bacteria. Proceedings of the National Academy of Sciences of the United States of America. 105: 4595-600. PMID 18250311 DOI: 10.1073/Pnas.0710107105  0.298
2011 Lee Y, Choi JY, Fu H, Harvey C, Ravindran S, Roush WR, Boothroyd JC, Khosla C. Chemistry and biology of macrolide antiparasitic agents. Journal of Medicinal Chemistry. 54: 2792-804. PMID 21428405 DOI: 10.1021/Jm101593U  0.298
1994 Fu H, McDaniel R, Hopwood DA, Khosla C. Engineered biosynthesis of novel polyketides: stereochemical course of two reactions catalyzed by a polyketide synthase. Biochemistry. 33: 9321-9326. PMID 8049233 DOI: 10.1021/Bi00197A036  0.297
2014 Le BV, Klöck C, Schatz A, Nguyen JB, Kakani EG, Catteruccia F, Khosla C, Baxter RH. Dihydroisoxazole inhibitors of Anopheles gambiae seminal transglutaminase AgTG3. Malaria Journal. 13: 210. PMID 24888439 DOI: 10.1186/1475-2875-13-210  0.295
2015 Lowry B, Walsh CT, Khosla C. In Vitro Reconstitution of Metabolic Pathways: Insights into Nature's Chemical Logic. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 26: 1008-1025. PMID 26207083 DOI: 10.1055/S-0034-1380264  0.294
1992 Khosla C, Ebert-Khosla S, Hopwood DA. Targeted gene replacements in a Streptomyces polyketide synthase gene cluster: role for the acyl carrier protein. Molecular Microbiology. 6: 3237-3249. PMID 1453961 DOI: 10.1111/J.1365-2958.1992.Tb01778.X  0.293
2011 Klöck C, Jin X, Choi K, Khosla C, Madrid PB, Spencer A, Raimundo BC, Boardman P, Lanza G, Griffin JH. Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2. Bioorganic & Medicinal Chemistry Letters. 21: 2692-6. PMID 21215619 DOI: 10.1016/J.Bmcl.2010.12.037  0.291
2005 Khosla C, Gray GM, Sollid LM. Putative efficacy and dosage of prolyl endopeptidase for digesting and detoxifying gliadin peptides. Gastroenterology. 129: 1362-3; author reply. PMID 16230098 DOI: 10.1053/J.Gastro.2005.08.044  0.291
2010 Valenzano CR, You YO, Garg A, Keatinge-Clay A, Khosla C, Cane DE. Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase. Journal of the American Chemical Society. 132: 14697-9. PMID 20925342 DOI: 10.1021/Ja107344H  0.285
2017 Xie X, Khosla C, Cane DE. Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases. Journal of the American Chemical Society. PMID 28430424 DOI: 10.1021/Jacs.7B02911  0.284
2019 Palanski B, Hilmer A, Weng N, Zhang L, Fall L, Elias J, Fernandez-Becker N, Khosla C. 598 – Identification of Immunotoxic Peptides from Dietary Wheat in Human Urine Gastroenterology. 156: S-118-S-119. DOI: 10.1016/S0016-5085(19)37089-1  0.284
1997 Kao CM, McPherson M, McDaniel RN, Fu H, Cane DE, Khosla C. Gain of function mutagenesis of the erythromycin polyketide synthase. 2. Engineered biosynthesis of an eight-membered ring tetraketide lactone Journal of the American Chemical Society. 119: 11339-11340. DOI: 10.1021/Ja972609E  0.284
2009 Khosla C, Kapur S, Cane DE. Revisiting the modularity of modular polyketide synthases. Current Opinion in Chemical Biology. 13: 135-43. PMID 19217343 DOI: 10.1016/J.Cbpa.2008.12.018  0.284
2015 Yi MC, Palanski BA, Quintero SA, Plugis NM, Khosla C. An unprecedented dual antagonist and agonist of human Transglutaminase 2. Bioorganic & Medicinal Chemistry Letters. PMID 26004580 DOI: 10.1016/J.Bmcl.2015.05.006  0.283
2004 Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM. An antibiotic factory caught in action. Nature Structural & Molecular Biology. 11: 888-93. PMID 15286722 DOI: 10.1038/Nsmb808  0.283
1996 Kao CM, Luo G, Katz L, Cane DE, Khosla C. Engineered biosynthesis of structurally diverse tetraketides by a trimodular polyketide synthase Journal of the American Chemical Society. 118: 9184-9185. DOI: 10.1021/Ja9617552  0.283
2020 Yuet KP, Khosla C. Challenges and opportunities for engineering assembly-line polyketide biosynthesis in . Metabolic Engineering Communications. 10: e00106. PMID 32547924 DOI: 10.1016/J.Mec.2019.E00106  0.282
2010 Stamnaes J, Pinkas DM, Fleckenstein B, Khosla C, Sollid LM. Redox regulation of transglutaminase 2 activity. The Journal of Biological Chemistry. 285: 25402-9. PMID 20547769 DOI: 10.1074/Jbc.M109.097162  0.282
2011 Sollid LM, Khosla C. Novel therapies for coeliac disease. Journal of Internal Medicine. 269: 604-13. PMID 21401739 DOI: 10.1111/J.1365-2796.2011.02376.X  0.282
2019 Khosla C. From Active Sites to Machines: A Challenge for Enzyme Chemists. Israel Journal of Chemistry. 59: 37-40. PMID 31762490 DOI: 10.1002/Ijch.201800098  0.281
1995 McDaniel R, Hutchinson CR, Khosla C. Engineered biosynthesis of novel polyketides: Analysis of TcmN function in tetracenomycin biosynthesis Journal of the American Chemical Society. 117: 6805-6810. DOI: 10.1021/Ja00131A001  0.281
2002 Dordick JS, Khosla C. Engineering of molecular and cellular biocatalysts: Selected contributions by James E. Bailey Biotechnology and Bioengineering. 79: 490-495. PMID 12209820 DOI: 10.1002/Bit.10404  0.281
2015 Plugis NM, Khosla C. Therapeutic approaches for celiac disease. Best Practice & Research. Clinical Gastroenterology. 29: 503-521. PMID 26060114 DOI: 10.1016/J.Bpg.2015.04.005  0.28
2017 Okesli A, Khosla C, Bassik MC. Human pyrimidine nucleotide biosynthesis as a target for antiviral chemotherapy. Current Opinion in Biotechnology. 48: 127-134. PMID 28458037 DOI: 10.1016/J.Copbio.2017.03.010  0.278
2017 Khosla C. Celiac Disease: Lessons for and from Chemical Biology. Acs Chemical Biology. PMID 28165712 DOI: 10.1021/Acschembio.6B01155  0.277
1994 Kao CM, Luo G, Katz L, Cane DE, Khosla C. Engineered Biosynthesis Of A Triketide Lactone From An Incomplete Modular Polyketide Synthase Journal of the American Chemical Society. 116: 11612-11613. DOI: 10.1021/Ja00104A069  0.277
2020 Abadie V, Kim SM, Lejeune T, Palanski BA, Ernest JD, Tastet O, Voisine J, Discepolo V, Marietta EV, Hawash MBF, Ciszewski C, Bouziat R, Panigrahi K, Horwath I, Zurenski MA, ... ... Khosla C, et al. IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease. Nature. PMID 32051586 DOI: 10.1038/S41586-020-2003-8  0.275
2001 Khosla C. Natural product biosynthesis: a new interface between enzymology and medicine. The Journal of Organic Chemistry. 65: 8127-33. PMID 11101363 DOI: 10.1021/Jo000849Y  0.275
1995 Cane DE, Luo G, Khosla C, Kao CM, Katz L. Erythromycin biosynthesis. Highly efficient incorporation of polyketide chain elongation intermediates into 6-deoxyerythronolide B in an engineered streptomyces host Journal of Antibiotics. 48: 647-651. PMID 7649863 DOI: 10.7164/Antibiotics.48.647  0.275
2011 Yuan L, Holmes TC, Watts RE, Khosla C, Broekelmann TJ, Mecham R, Zheng H, Izaguirre EW, Rich KM. Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas. Journal of Neuro-Oncology. 103: 207-19. PMID 20824305 DOI: 10.1007/S11060-010-0379-2  0.274
2017 Xiao X, Sankaranarayanan K, Khosla C. Biosynthesis and structure-activity relationships of the lipid a family of glycolipids. Current Opinion in Chemical Biology. 40: 127-137. PMID 28942130 DOI: 10.1016/J.Cbpa.2017.07.008  0.273
1996 Carreras CW, Pieper R, Khosla C. Efficient Synthesis of Aromatic Polyketides in Vitro by the Actinorhodin Polyketide Synthase Journal of the American Chemical Society. 118: 5158-5159. DOI: 10.1021/Ja960479O  0.273
2013 May AE, Khosla C. Discovery and mechanism of Type III secretion system inhibitors Israel Journal of Chemistry. 53: 577-587. DOI: 10.1002/Ijch.201300025  0.272
2012 Diraimondo TR, Klöck C, Khosla C. Interferon-γ activates transglutaminase 2 via a phosphatidylinositol-3-kinase-dependent pathway: implications for celiac sprue therapy. The Journal of Pharmacology and Experimental Therapeutics. 341: 104-14. PMID 22228808 DOI: 10.1124/Jpet.111.187385  0.269
2010 Liu T, Khosla C. Chemistry. A balancing act for Taxol precursor pathways in E. coli. Science (New York, N.Y.). 330: 44-5. PMID 20929799 DOI: 10.1126/Science.1195014  0.268
1998 Jacobsen JR, Khosla C. New directions in metabolic engineering. Current Opinion in Chemical Biology. 2: 133-7. PMID 9667907 DOI: 10.1016/S1367-5931(98)80045-8  0.268
2014 Klöck C, Herrera Z, Albertelli M, Khosla C. Discovery of potent and specific dihydroisoxazole inhibitors of human transglutaminase 2. Journal of Medicinal Chemistry. 57: 9042-64. PMID 25333388 DOI: 10.1021/Jm501145A  0.266
1994 Fu H, Ebert-Khosla S, Hopwood DA, Khosla C. Relaxed Specificity of the Oxytetracycline Polyketide Synthase for an Acetate Primer in the Absence of a Malonamyl Primer Journal of the American Chemical Society. 116: 6443-6444. DOI: 10.1021/Ja00093A058  0.265
2017 Garber ME, Saldanha A, Parker JS, Jones WD, Kaukinen K, Laurila K, Lähdeaho ML, Khatri P, Khosla C, Adelman DC, Mäki M. A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac Disease. Cellular and Molecular Gastroenterology and Hepatology. 4: 1-17. PMID 28508029 DOI: 10.1016/J.Jcmgh.2017.01.011  0.263
2019 Khosla C. Harnessing the Biosynthetic Potential of Modular Polyketide Synthases. Chemical Reviews. 97: 2577-2590. PMID 11851472 DOI: 10.1021/Cr960027U  0.263
2010 Matic I, Sacchi A, Rinaldi A, Melino G, Khosla C, Falasca L, Piacentini M. Characterization of transglutaminase type II role in dendritic cell differentiation and function. Journal of Leukocyte Biology. 88: 181-8. PMID 20371597 DOI: 10.1189/Jlb.1009691  0.261
2013 Morón B, Verma AK, Das P, Taavela J, Dafik L, Diraimondo TR, Albertelli MA, Kraemer T, Mäki M, Khosla C, Rogler G, Makharia GK. CYP3A4-catalyzed simvastatin metabolism as a non-invasive marker of small intestinal health in celiac disease. The American Journal of Gastroenterology. 108: 1344-51. PMID 23732466 DOI: 10.1038/Ajg.2013.151  0.259
2020 Liu Q, Gupta A, Okesli-Armlovich A, Qiao W, Fischer CR, Smith M, Carette JE, Bassik MC, Khosla C. Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism. Cell Chemical Biology. PMID 32442424 DOI: 10.1016/J.Chembiol.2020.05.002  0.258
1998 Pohl NL, Gokhale RS, Cane DE, Khosla C. Synthesis and incorporation of an N-acetylcysteamine analogue of methylmalonyl-CoA by a modular polyketide synthase [13] Journal of the American Chemical Society. 120: 11206-11207. DOI: 10.1021/Ja9830290  0.258
2007 Katz L, Khosla C. Antibiotic production from the ground up. Nature Biotechnology. 25: 428-9. PMID 17420748 DOI: 10.1038/Nbt0407-428  0.258
1996 Khosla C. Combinatorial chemistry and biology: an opportunity for engineers. Current Opinion in Biotechnology. 7: 219-22. PMID 8791337 DOI: 10.1016/S0958-1669(96)80016-4  0.256
2000 Hu Z, Hopwood DA, Khosla C. Directed transfer of large DNA fragments between Streptomyces species. Applied and Environmental Microbiology. 66: 2274-7. PMID 10788417 DOI: 10.1128/Aem.66.5.2274-2277.2000  0.255
1997 Kramer PJ, Khosla C. Engineering of novel polyketides. Progress and Prospects. Annals of the New York Academy of Sciences. 799: 32-45. PMID 8958070 DOI: 10.1111/J.1749-6632.1996.Tb33174.X  0.254
2015 Lebwohl B, Murray JA, Verdú EF, Crowe SE, Dennis M, Fasano A, Green PH, Guandalini S, Khosla C. Gluten Introduction, Breastfeeding, and Celiac Disease: Back to the Drawing Board. The American Journal of Gastroenterology. PMID 26259710 DOI: 10.1038/Ajg.2015.219  0.253
2013 Chen JK, Du Bois J, Glenn J, Herschlag D, Khosla C. The Stanford Institute for Chemical Biology. Acs Chemical Biology. 8: 1860-1. PMID 24053754 DOI: 10.1021/Cb400641U  0.253
2014 Khosla C. The Convergence of Chemistry & Human Biology Daedalus. 143: 43-48. DOI: 10.1162/Daed_A_00304  0.252
2013 Garg A, Khosla C, Cane DE. Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange. Journal of the American Chemical Society. 135: 16324-7. PMID 24161343 DOI: 10.1021/Ja408944S  0.251
2017 Wibowo A, Park JM, Liu SC, Khosla C, Spielman DM. Real-time in vivo detection of H2O2 using hyperpolarized 13C-thiourea. Acs Chemical Biology. PMID 28452454 DOI: 10.1021/Acschembio.7B00130  0.251
2016 Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC. Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification. Nature Chemical Biology. PMID 27018887 DOI: 10.1038/Nchembio.2050  0.25
2017 Mathews II, Allison K, Robbins T, Lyubimov A, Uervirojnangkoorn M, Brunger AT, Khosla C, DeMirci H, McPhillips SE, Hollenbeck M, Soltis SM, Cohen AE. Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase is revealed at an X-Ray Free Electron Laser using a Room-Temperature Sample Delivery Method for Serial Crystallography. Biochemistry. PMID 28832129 DOI: 10.1021/Acs.Biochem.7B00711  0.249
1998 McPherson M, Khosla C, Cane DE. Erythromycin biosynthesis: The β-ketoreductase domains catalyze the stereospecific transfer of the 4-pro-S hydride of NADPH [2] Journal of the American Chemical Society. 120: 3267-3268. DOI: 10.1021/Ja980028Z  0.249
1993 Hopwood DA, Khosla C. Genes for polyketide secondary metabolic pathways in microorganisms and plants. Ciba Foundation Symposium. 171: 88-106; discussion 1. PMID 1302187 DOI: 10.1002/9780470514344.ch6  0.249
2011 Fitzgerald JT, Henrich PP, O'Brien C, Krause M, Ekland EH, Mattheis C, Sá JM, Fidock D, Khosla C. In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei. The Journal of Antibiotics. 64: 799-801. PMID 22008701 DOI: 10.1038/Ja.2011.94  0.248
2020 Yuet KP, Liu CW, Lynch SR, Kuo J, Michaels W, Lee RB, McShane AE, Zhong BL, Fischer CR, Khosla C. Complete reconstitution and deorphanization of the 3 MDa nocardiosis-associated polyketide synthase. Journal of the American Chemical Society. PMID 32182063 DOI: 10.1021/Jacs.0C00904  0.247
2014 Penumatsa KC, Toksoz D, Warburton RR, Hilmer AJ, Liu T, Khosla C, Comhair SA, Fanburg BL. Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 307: L576-85. PMID 25128524 DOI: 10.1152/Ajplung.00162.2014  0.247
2017 Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Costes LM, Lawrence I, Palanski BA, ... ... Khosla C, et al. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science (New York, N.Y.). 356: 44-50. PMID 28386004 DOI: 10.1126/Science.Aah5298  0.245
2016 Hilmer AJ, Jeffrey RB, Park WG, Khosla C. Cholestyramine as a promising, strong anion exchange resin for direct capture of genetic biomarkers from raw pancreatic fluids. Biotechnology and Bioengineering. PMID 27800600 DOI: 10.1002/Bit.26207  0.245
2002 Khosla C. Biochemistry—engineering interface in biochemical engineering Aiche Journal. 48: 1366-1368. DOI: 10.1002/Aic.690480702  0.245
2012 Morón B, Verma AK, Das P, Taavela J, Dafik L, DiRaimondo TR, Albertelli M, Kraemer T, Mäki M, Khosla C, Rogler G, Makharia GK. Sa1313 Simvastatin Metabolism by Small Intestinal CYP3A4 as a Non-Invasive Biomarker for the Diagnosis and Routine Monitoring of Celiac Disease Gastroenterology. 142: S-270. DOI: 10.1016/S0016-5085(12)61020-8  0.244
1995 Kao CM, Luo G, Katz L, Cane DE, Khosla C. Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase Journal of the American Chemical Society. 117: 9105-9106. DOI: 10.1021/Ja00140A043  0.243
2017 Cooke TF, Fischer CR, Wu P, Jiang TX, Xie KT, Kuo J, Doctorov E, Zehnder A, Khosla C, Chuong CM, Bustamante CD. Genetic Mapping and Biochemical Basis of Yellow Feather Pigmentation in Budgerigars. Cell. 171: 427-439.e21. PMID 28985565 DOI: 10.1016/J.Cell.2017.08.016  0.242
2017 Syage JA, Murray JA, Green PHR, Khosla C. Latiglutenase Improves Symptoms in Seropositive Celiac Disease Patients While on a Gluten-Free Diet. Digestive Diseases and Sciences. PMID 28755266 DOI: 10.1007/S10620-017-4687-7  0.242
2013 Han A, Newell EW, Glanville J, Fernandez-Becker N, Khosla C, Chien YH, Davis MM. Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease. Proceedings of the National Academy of Sciences of the United States of America. 110: 13073-8. PMID 23878218 DOI: 10.1073/Pnas.1311861110  0.24
1997 McDaniel R, Kao CM, Fu H, Hevezi P, Gustafsson C, Betlach M, Ashley G, Cane DE, Khosla C. Gain-of-function mutagenesis of a modular polyketide synthase Journal of the American Chemical Society. 119: 4309-4310. DOI: 10.1021/Ja9702531  0.239
2014 Stevenson HP, Makhov AM, Calero M, Edwards AL, Zeldin OB, Mathews II, Lin G, Barnes CO, Santamaria H, Ross TM, Soltis SM, Khosla C, Nagarajan V, Conway JF, Cohen AE, et al. Use of transmission electron microscopy to identify nanocrystals of challenging protein targets. Proceedings of the National Academy of Sciences of the United States of America. 111: 8470-5. PMID 24872454 DOI: 10.1073/Pnas.1400240111  0.238
2017 Penumatsa KC, Toksoz D, Warburton RR, Kharnaf M, Preston IR, Kapur NK, Khosla C, Hill NS, Fanburg BL. Transglutaminase 2 in Pulmonary and Cardiac Tissue Remodeling in Experimental Pulmonary Hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00170.2017. PMID 28775095 DOI: 10.1152/Ajplung.00170.2017  0.238
1998 Hunziker D, Yu TW, Hutchinson CR, Floss HG, Khosla C. Primer unit specificity in rifamycin biosynthesis principally resides in the later stages of the biosynthetic pathway [12] Journal of the American Chemical Society. 120: 1092-1093. DOI: 10.1021/Ja9736368  0.236
2012 Holmes TC, May AE, Zaleta-Rivera K, Ruby JG, Skewes-Cox P, Fischbach MA, DeRisi JL, Iwatsuki M, ÅŒmura S, Khosla C. Molecular insights into the biosynthesis of guadinomine: a type III secretion system inhibitor. Journal of the American Chemical Society. 134: 17797-806. PMID 23030602 DOI: 10.1021/ja308622d  0.235
2018 Plugis NM, Weng N, Zhao Q, Palanski BA, Maecker HT, Habtezion A, Khosla C. Interleukin 4 is inactivated via selective disulfide-bond reduction by extracellular thioredoxin. Proceedings of the National Academy of Sciences of the United States of America. PMID 30104382 DOI: 10.1073/Pnas.1805288115  0.23
2005 Pyle GG, Paaso B, Anderson BE, Allen D, Marti T, Khosla C, Gray GM. Low-dose gluten challenge in celiac sprue: malabsorptive and antibody responses. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 3: 679-86. PMID 16206501 DOI: 10.1016/S1542-3565(05)00365-4  0.23
2014 DiRaimondo TR, Klöck C, Warburton R, Herrera Z, Penumatsa K, Toksoz D, Hill N, Khosla C, Fanburg B. Elevated transglutaminase 2 activity is associated with hypoxia-induced experimental pulmonary hypertension in mice. Acs Chemical Biology. 9: 266-75. PMID 24152195 DOI: 10.1021/Cb4006408  0.226
2007 Gass J, Khosla C. Prolyl endopeptidases. Cellular and Molecular Life Sciences : Cmls. 64: 345-55. PMID 17160352 DOI: 10.1007/s00018-006-6317-y  0.226
2015 Khosla C. Quo vadis, enzymology? Nature Chemical Biology. 11: 438-41. PMID 26083060 DOI: 10.1038/Nchembio.1844  0.226
2018 Voyksner JAS, Murray JA, Khosla C, Syage JA. Mo1045 - Simvastatin as a Biomarker for Intestinal Villous Health for Recovering Celiac Disease Patients Gastroenterology. 154: S-682. DOI: 10.1016/S0016-5085(18)32406-5  0.223
2013 Xu H, Feely SL, Wang X, Liu DX, Borda JT, Dufour J, Li W, Aye PP, Doxiadis GG, Khosla C, Veazey RS, Sestak K. Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease. Clinical Immunology (Orlando, Fla.). 147: 40-9. PMID 23518597 DOI: 10.1016/J.Clim.2013.02.012  0.222
2001 Roberts RJ, Varmus HE, Ashburner M, Brown PO, Eisen MB, Khosla C, Kirschner M, Nusse R, Scott M, Wold B. Information access. Building a "GenBank" of the published literature. Science (New York, N.Y.). 291: 2318-9. PMID 11269300 DOI: 10.1126/Science.1060273  0.217
2019 Voyksner JAS, Murray JA, Khosla C, Dickason MA, Syage JA. Mo1985 – Minimally-Invasive Monitoring of Intestinal Villous Health in Recovering Celiac Disease Patients Gastroenterology. 156: S-911-S-912. DOI: 10.1016/S0016-5085(19)39248-0  0.217
1998 Kao CM, McPherson M, McDaniel RN, Fu H, Cane DE, Khosla C. Alcohol stereochemistry in polyketide backbones is controlled by the β-ketoreductase domains of modular polyketide synthases Journal of the American Chemical Society. 120: 2478-2479. DOI: 10.1021/Ja973913A  0.216
2016 Khosla C, Baryza J. Editorial overview: Next-generation therapeutics: Breaking new ground and making a difference for patients. Current Opinion in Chemical Biology. 32: 58-59. PMID 27206139 DOI: 10.1016/J.Cbpa.2016.04.017  0.216
2022 Palanski BA, Weng N, Zhang L, Hilmer AJ, Fall LA, Swaminathan K, Jabri B, Sousa C, Fernandez-Becker NQ, Khosla C, Elias JE. An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease. Nature Communications. 13: 888. PMID 35173144 DOI: 10.1038/s41467-022-28353-1  0.213
1998 Jacobsen JR, Cane DE, Khosla C. Dissecting the evolutionary relationship between 14-membered and 16- membered macrolides [14] Journal of the American Chemical Society. 120: 9096-9097. DOI: 10.1021/Ja9819514  0.212
2014 Park K, Harris M, Khavari N, Khosla C. Rationale for Using Social Media to Collect Patient-Reported Outcomes in Patients with Celiac Disease. Journal of Gastrointestinal & Digestive System. 4. PMID 25392743 DOI: 10.4172/2161-069X.1000166  0.212
2021 Klaus M, Rossini E, Linden A, Paithankar KS, Zeug M, Ignatova Z, Urlaub H, Khosla C, Köfinger J, Hummer G, Grininger M. Solution Structure and Conformational Flexibility of a Polyketide Synthase Module. Jacs Au. 1: 2162-2171. PMID 34977887 DOI: 10.1021/jacsau.1c00043  0.211
2022 Loppinet E, Besser HA, Sewa AS, Yang FC, Jabri B, Khosla C. LRP-1 links post-translational modifications to efficient presentation of celiac disease-specific T cell antigens. Cell Chemical Biology. PMID 36608691 DOI: 10.1016/j.chembiol.2022.12.002  0.211
2023 Guzman KM, Cogan DP, Brodsky KL, Soohoo AM, Li X, Sevillano N, Mathews II, Nguyen KP, Craik CS, Khosla C. Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase. Biochemistry. PMID 37184546 DOI: 10.1021/acs.biochem.3c00156  0.209
2017 Syage JA, Murray JA, Green PH, Khosla C, Adelman DC, Sealey Voyksner JA. Oral Latiglutenase Improves Chronic Symptoms in Seropositive Celiac Disease Patients Gastroenterology. 152: S163. DOI: 10.1016/S0016-5085(17)30865-X  0.208
2023 Loppinet E, Besser HA, Lee CE, Zhang W, Cui B, Khosla C. Targeted Lysosomal Degradation of Secreted and Cell Surface Proteins through the LRP-1 Pathway. Journal of the American Chemical Society. 145: 18705-18710. PMID 37590164 DOI: 10.1021/jacs.3c05109  0.204
2016 Guo S, Palanski BA, Kloeck C, Khosla C, Cui B. Intracellular TG2 Activity Increases Microtubule Stability but is not Sufficient to Prompt Neurite Growth. Neuroscience Bulletin. PMID 27815680 DOI: 10.1007/S12264-016-0075-0  0.203
2012 Harvey CJB, Khosla C. Precursor-Directed Biosynthesis of Polyketide and Nonribosomal Peptide Natural Products Modern Tools For the Synthesis of Complex Bioactive Molecules. 485-512. DOI: 10.1002/9781118342886.ch14  0.202
2020 Santín O, Yuet K, Khosla C, Moncalián G. Structure and Mechanism of the Ketosynthase-Chain Length Factor Didomain from a Prototypical Polyunsaturated Fatty Acid Synthase. Biochemistry. PMID 33283513 DOI: 10.1021/acs.biochem.0c00785  0.198
2021 Guzman KM, Yuet KP, Lynch SR, Liu CW, Khosla C. Properties of a "Split-and-Stuttering" Module of an Assembly Line Polyketide Synthase. The Journal of Organic Chemistry. PMID 33755455 DOI: 10.1021/acs.joc.1c00120  0.197
2024 Kishore S, Del Rio Flores A, Lynch SR, Yuet KP, Khosla C. Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural Product. Journal of the American Chemical Society. PMID 38295028 DOI: 10.1021/jacs.3c13670  0.196
2022 Sirirungruang S, Ad O, Privalsky TM, Ramesh S, Sax JL, Dong H, Baidoo EEK, Amer B, Khosla C, Chang MCY. Engineering site-selective incorporation of fluorine into polyketides. Nature Chemical Biology. 18: 886-893. PMID 35817967 DOI: 10.1038/s41589-022-01070-y  0.193
2001 Khosla C, Harbury PB. Modular enzymes. Nature. 409: 247-52. PMID 11196653 DOI: 10.1038/35051723  0.186
2022 Hsu J, Fatuzzo N, Weng N, Michno W, Dong W, Kienle M, Dai Y, Pasca A, Abu-Remaileh M, Rasgon N, Bigio B, Nasca C, Khosla C. Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells. The Journal of Biological Chemistry. 102848. PMID 36587768 DOI: 10.1016/j.jbc.2022.102848  0.186
2023 Besser HA, Khosla C. Celiac disease: mechanisms and emerging therapeutics. Trends in Pharmacological Sciences. 44: 949-962. PMID 37839914 DOI: 10.1016/j.tips.2023.09.006  0.183
1997 Khosla C. An old dog in search of new ticks Nature Biotechnology. 15: 1021-1022. DOI: 10.1038/Nbt1097-1021  0.182
2022 Abadie V, Khosla C, Jabri B. A Mouse Model of Celiac Disease. Current Protocols. 2: e515. PMID 35994521 DOI: 10.1002/cpz1.515  0.181
2022 Guzman KM, Khosla C. Fragment antigen binding domains (Fs) as tools to study assembly-line polyketide synthases. Synthetic and Systems Biotechnology. 7: 506-512. PMID 34977395 DOI: 10.1016/j.synbio.2021.12.003  0.173
2022 Mashayekh S, Stunkard LM, Kienle M, Mathews II, Khosla C. Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2). Biochemistry. PMID 36190114 DOI: 10.1021/acs.biochem.2c00451  0.169
2011 Chen AY, Khosla C. Protein Engineering of Modular Polyketide Synthases Protein Engineering Handbook, Volume 1 & Volume 2. 2: 797-827. DOI: 10.1002/9783527634026.ch32  0.167
2006 Pinkas DM, Strop P, Khosla C, Clark JH. A peptide inhibitor reveals an extended conformation of Transglutaminase 2 Aiche Annual Meeting, Conference Proceedings.  0.16
2008 Vora H, Lu X, Khosla C. Scaleable production of free fatty acids in E. Coli: Implications for biodiesel production Aiche Annual Meeting, Conference Proceedings.  0.154
2010 TSOI CJ, KHOSLA C. ChemInform Abstract: Combinatorial Biosynthesis of “Unnatural” Natural Products: The Polyketide Example Cheminform. 26: no-no. DOI: 10.1002/chin.199550253  0.153
2007 Shan L, Khosla C. Chemistry and biology of gluten proteins Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 7: 187-193. DOI: 10.2174/187152207780832397  0.151
2008 Tse ML, Khosla C. Engineering and Overproduction of Polyketide Natural Products Modern Biopharmaceuticals: Design, Development and Optimization. 4: 1803-1832. DOI: 10.1002/9783527620982.ch74  0.148
2012 Yu X, Khosla C. Engineering escherichia coli for biotransformation of biomass into fatty acid derived fuels Current Chemical Biology. 6: 7-13.  0.146
2023 Kishore S, Khosla C. Genomic mining and diversity of assembly line polyketide synthases. Open Biology. 13: 230096. PMID 37528731 DOI: 10.1098/rsob.230096  0.14
2021 Nivina A, Herrera Paredes S, Fraser HB, Khosla C. GRINS: Genetic elements that recode assembly-line polyketide synthases and accelerate their diversification. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34162709 DOI: 10.1073/pnas.2100751118  0.139
2010 PIEPER R, KAO C, KHOSLA C, LUO G, CANE DE. ChemInform Abstract: Specificity and Versatility in Erythromycin Biosynthesis Cheminform. 28: no-no. DOI: 10.1002/chin.199717290  0.137
1994 Kao CM, Luo G, Katz L, Cane DE, Khosla C. Engineered biosynthesis of a triketide lactone from an incomplete modular polyketide synthase Journal of the American Chemical Society. 116: 11612-11613.  0.133
2001 Khosla C. ChemInform Abstract: Natural Product Biosynthesis: A New Interface Between Enzymology and Medicine Cheminform. 32: no-no. DOI: 10.1002/chin.200110295  0.13
2021 Privalsky TM, Soohoo AM, Wang J, Walsh CT, Wright GD, Gordon EM, Gray NS, Khosla C. Prospects for Antibacterial Discovery and Development. Journal of the American Chemical Society. 143: 21127-21142. PMID 34860516 DOI: 10.1021/jacs.1c10200  0.13
2023 Levitt JE, Hedlin H, Duong S, Lu D, Lee J, Bunning B, Elkarra N, Pinsky BA, Heffernan E, Springman E, Moss RB, Bonilla HF, Parsonnet J, Zamanian RT, Langguth JJ, ... ... Khosla C, et al. Evaluation of acebilustat, a selective inhibitor of leukotriene B4 biosynthesis, for treatment of outpatients with mild-moderate COVID-19 disease: A randomized, double-blind, placebo- controlled Phase 2 trial. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 36996150 DOI: 10.1093/cid/ciad187  0.112
2010 KHOSLA C. ChemInform Abstract: Harnessing the Biosynthetic Potential of Modular Polyketide Synthases Cheminform. 29: no-no. DOI: 10.1002/chin.199806314  0.104
2008 Jackson AB, Khosla C, White PS, Templeton JL. Reduction of an eta2-iminoacyl ligand to eta2-iminium enabled by adjacent carbon monoxide ligand replacement with a variable electron donor alkyne ligand in a cationic Tungsten(II) bis(acetylacetonate) complex. Inorganic Chemistry. 47: 8776-87. PMID 18754617 DOI: 10.1021/Ic800738A  0.102
2021 Cogan DP, Zhang K, Li X, Li S, Pintilie GD, Roh SH, Craik CS, Chiu W, Khosla C. Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science (New York, N.Y.). 374: 729-734. PMID 34735239 DOI: 10.1126/science.abi8358  0.101
2015 Lowry B, Walsh CT, Khosla C. In Vitro Reconstitution of Metabolic Pathways: Insights into Nature’s Chemical Logic Synlett. DOI: 10.1055/s-0034-1380264  0.099
2014 May AE, Khosla C. Macrolides and Antifungals via Biotransformation Natural Products in Medicinal Chemistry. 365-402. DOI: 10.1002/9783527676545.ch11  0.099
2013 Lowry B, Khosla C. Analysis and engineering of modular polyketide synthase systems Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area At the 2013 Aiche Annual Meeting: Global Challenges For Engineering a Sustainable Future. 337.  0.097
2022 Goodyer WR, Beyersdorf BM, Duan L, van den Berg NS, Mantri S, Galdos FX, Puluca N, Buikema JW, Lee S, Salmi D, Robinson ER, Rogalla S, Cogan DP, Khosla C, Rosenthal EL, et al. In vivo visualization and molecular targeting of the cardiac conduction system. The Journal of Clinical Investigation. PMID 35951416 DOI: 10.1172/JCI156955  0.096
2009 Khosla C. Modular biocatalysts Aiche Journal. 55: 1926-1929. DOI: 10.1002/aic.11981  0.093
1995 Kao CM, Luo G, Katz L, Cane DE, Khosla C. Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase Journal of the American Chemical Society. 117: 9105-9106.  0.092
2008 Jackson AB, Khosla C, Gaskins HE, White PS, Templeton JL. Reduction of π-bound nitriles to π-bound imines in a tungsten(II) bis(acetylacetonate) coordination sphere Organometallics. 27: 1322-1327. DOI: 10.1021/Om7009039  0.088
2021 Bunning B, Hedlin H, Purington N, Sundaram V, Kapphahn K, Weng Y, Cunanan K, Maldonado Y, Singh U, Khosla C, O'Hara R, Nicolls M, Springman E, Parsonnet J, Rogers A, et al. The COVID-19 Outpatient Pragmatic Platform Study (COPPS): Study design of a multi-center pragmatic platform trial. Contemporary Clinical Trials. 106509. PMID 34274494 DOI: 10.1016/j.cct.2021.106509  0.086
2022 Chakraborty S, Gonzalez JC, Sievers BL, Mallajosyula V, Chakraborty S, Dubey M, Ashraf U, Cheng BY, Kathale N, Tran KQT, Scallan C, Sinnott A, Cassidy A, Chen ST, Gelbart T, ... ... Khosla C, et al. Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity. Science Translational Medicine. eabm7853. PMID 35040666 DOI: 10.1126/scitranslmed.abm7853  0.084
2011 Khosla C, Jackson AB, White PS, Templeton JL. Synthesis and isocyanate insertion reactions of tungsten(IV) imido complexes formed from W(CO)(acac)(N3)(PMe3)3 with azide as the oxidant Inorganica Chimica Acta. 369: 19-31. DOI: 10.1016/J.Ica.2010.10.032  0.083
2010 KHOSLA C, ZAWADA RJX. ChemInform Abstract: Generation of Polyketide Libraries via Combinatorial Biosynthesis Cheminform. 28: no-no. DOI: 10.1002/chin.199708283  0.079
2012 Khosla C, Jackson AB, White PS, Templeton JL. Bis(acetylacetonate) tungsten(IV) complexes containing a π-basic diazoalkane or oxo ligand Organometallics. 31: 987-994. DOI: 10.1021/Om201050J  0.076
2021 Li J, Zaslavsky M, Su Y, Sikora MJ, van Unen V, Christophersen A, Chiou SH, Chen L, Li J, Ji X, Wilhelmy J, McSween AM, Palanski BA, Aditya Mallajosyula VV, Dhondalay GKR, ... ... Khosla C, et al. Human KIR CD8 T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19. Biorxiv : the Preprint Server For Biology. PMID 34981055 DOI: 10.1101/2021.12.23.473930  0.075
2022 Li J, Zaslavsky M, Su Y, Guo J, Sikora MJ, van Unen V, Christophersen A, Chiou SH, Chen L, Li J, Ji X, Wilhelmy J, McSween AM, Palanski BA, Mallajosyula VVA, ... ... Khosla C, et al. KIRCD8 T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19. Science (New York, N.Y.). eabi9591. PMID 35258337 DOI: 10.1126/science.abi9591  0.074
2010 KHOSLA C. ChemInform Abstract: Combinatorial Biosynthesis: New Tools for the Medicinal Chemist Cheminform. 29: no-no. DOI: 10.1002/chin.199822235  0.073
2022 Murray JA, Syage JA, Wu TT, Dickason MA, Ramos AG, Van Dyke C, Horwath I, Lavin PT, Mäki M, Hujoel I, Papadakis KA, Bledsoe AC, Khosla C, Sealey-Voyksner JA. Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients with Celiac Disease Exposed to a Gluten Challenge. Gastroenterology. PMID 35931103 DOI: 10.1053/j.gastro.2022.07.071  0.071
2019 Syage JA, Green PHR, Khosla C, Adelman DC, Sealey-Voyksner JA, Murray JA. Latiglutenase Treatment for Celiac Disease: Symptom and Quality of Life Improvement for Seropositive Patients on a Gluten-Free Diet. Gastrohep. 1: 293-301. PMID 32313451 DOI: 10.1002/ygh2.371  0.07
2009 Delp SA, Munro-Leighton C, Khosla C, Templeton JL, Alsop NM, Gunnoe TB, Cundari TR. Combined experimental and computational study of W(II), Ru(II), Pt(IV) and Cu(I) amine and amido complexes using 15N NMR spectroscopy Journal of Organometallic Chemistry. 694: 1549-1556. DOI: 10.1016/J.Jorganchem.2009.01.006  0.064
2005 Khosla C, Tang Y. A New Route to Designer Antibiotics Cheminform. 36. DOI: 10.1002/chin.200541259  0.059
2015 Lebwohl B, Murray JA, Verdú EF, Crowe SE, Dennis M, Fasano A, Green PHR, Guandalini S, Khosla C. Gluten Introduction, Breastfeeding, and Celiac Disease: Back to the Drawing Board American Journal of Gastroenterology. DOI: 10.1038/ajg.2015.219  0.059
2021 Melkonian AV, Loppinet E, Martin R, Porteus M, Khosla C. An Unusual "OR" Gate for Allosteric Regulation of Mammalian Transglutaminase 2 in the Extracellular Matrix. Journal of the American Chemical Society. PMID 34232639 DOI: 10.1021/jacs.1c04616  0.051
2022 Holubar M, Subramanian A, Purington N, Hedlin H, Bunning B, Walter KS, Bonilla H, Boumis A, Chen M, Clinton K, Dewhurst L, Epstein C, Jagannathan P, Kaszynski RH, Panu L, ... ... Khosla C, et al. Favipiravir for treatment of outpatients with asymptomatic or uncomplicated COVID-19: a double-blind randomized, placebo-controlled, phase 2 trial. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 35446944 DOI: 10.1093/cid/ciac312  0.051
2022 Hu Z, van der Ploeg K, Chakraborty S, Arunachalam PS, Mori DAM, Jacobson KB, Bonilla H, Parsonnet J, Andrews JR, Holubar M, Subramanian A, Khosla C, Maldonado Y, Hedlin H, de la Parte L, et al. Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study. Elife. 11. PMID 36239699 DOI: 10.7554/eLife.77943  0.051
2014 Fernandes H, D'souza CR, Khosla C, George L, Katte NH. Role of FNAC in the Preoperative Diagnosis of Salivary Gland Lesions. Journal of Clinical and Diagnostic Research : Jcdr. 8: FC01-3. PMID 25386436 DOI: 10.7860/JCDR/2014/6735.4809  0.049
2010 Ambroise MM, Khosla C, Ghosh M, Mallikarjuna VS, Annapurneswari S. The role of immunohistochemistry in predicting behavior of astrocytic tumors. Asian Pacific Journal of Cancer Prevention : Apjcp. 11: 1079-84. PMID 21133628  0.047
2021 Jagannathan P, Andrews JR, Bonilla H, Hedlin H, Jacobson KB, Balasubramanian V, Purington N, Kamble S, de Vries CR, Quintero O, Feng K, Ley C, Winslow D, Newberry J, Edwards K, ... ... Khosla C, et al. Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial. Nature Communications. 12: 1967. PMID 33785743 DOI: 10.1038/s41467-021-22177-1  0.045
2011 Ambroise MM, Khosla C, Ghosh M, Mallikarjuna VS, Annapurneswari S. Practical value of MIB-1 index in predicting behavior of astrocytomas. Indian Journal of Pathology & Microbiology. 54: 520-5. PMID 21934213 DOI: 10.4103/0377-4929.85085  0.032
2021 Verma R, Kim E, Martínez-Colón GJ, Jagannathan P, Rustagi A, Parsonnet J, Bonilla H, Khosla C, Holubar M, Subramanian A, Singh U, Maldonado Y, Blish CA, Andrews JR. SARS-CoV-2 Subgenomic RNA Kinetics in Longitudinal Clinical Samples. Open Forum Infectious Diseases. 8: ofab310. PMID 34295944 DOI: 10.1093/ofid/ofab310  0.03
2023 Walter KS, Kim E, Verma R, Altamirano J, Leary S, Carrington YJ, Jagannathan P, Singh U, Holubar M, Subramanian A, Khosla C, Maldonado Y, Andrews JR. Challenges in Harnessing Shared Within-Host Severe Acute Respiratory Syndrome Coronavirus 2 Variation for Transmission Inference. Open Forum Infectious Diseases. 10: ofad001. PMID 36751652 DOI: 10.1093/ofid/ofad001  0.024
2021 Ni J, Khosla C, Maahs DM. 50 Years Ago in TheJournalofPediatrics: Association of Type 1 Diabetes Mellitus and Celiac Disease: Then and Now. The Journal of Pediatrics. 230: 70. PMID 33632400 DOI: 10.1016/j.jpeds.2020.10.050  0.024
2011 Khosla C. Better than Sliced Bread Letters to a Young Chemist. 155-164. DOI: 10.1002/9781118007099.ch10  0.01
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