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Chaitan Khosla - Related publications

Chemistry Stanford University, Palo Alto, CA 
Bioorganic and Biophysical Chemistry
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Chang HY, Lo LH, Lan YH, Hong MX, Chan YT, Ko TP, Huang YR, Cheng TH, Liaw CC. Structural insights into the substrate selectivity of α-oxoamine synthases from marine Vibrio sp. QWI-06. Colloids and Surfaces. B, Biointerfaces. 112224. PMID 34838420 DOI: 10.1016/j.colsurfb.2021.112224   
2021 Wei X, Matsuyama T, Sato H, Yan D, Chan PM, Miyamoto K, Uchiyama M, Matsuda Y. Molecular and Computational Bases for Spirofuranone Formation in Setosusin Biosynthesis. Journal of the American Chemical Society. PMID 34644070 DOI: 10.1021/jacs.1c08336   
2021 Xu L, Chang KC, Payne EM, Modavi C, Liu L, Palmer CM, Tao N, Alper HS, Kennedy RT, Cornett DS, Abate AR. Mapping enzyme catalysis with metabolic biosensing. Nature Communications. 12: 6803. PMID 34815408 DOI: 10.1038/s41467-021-27185-9   
2021 Salvi P, Kumar B, Kamble NU, Hazra A, Majee M. A Conserved NAG motif is critical to the catalytic activity of galactinol synthase, a key regulatory enzyme of RFO biosynthesis. The Biochemical Journal. PMID 34693969 DOI: 10.1042/BCJ20210703   
2021 Pogorevc D, Müller R. Biotechnological production optimization of argyrins - a potent immunomodulatory natural product class. Microbial Biotechnology. PMID 34724343 DOI: 10.1111/1751-7915.13959   
2021 Cui J, Chen H, Tang X, Zhang H, Chen YQ, Chen W. Consensus mutagenesis and computational simulation provide insight into the desaturation catalytic mechanism for delta 6 fatty acid desaturase. Biochemical and Biophysical Research Communications. 586: 74-80. PMID 34837835 DOI: 10.1016/j.bbrc.2021.11.050   
2021 Guimarães AVF, Frota NF, Lourenzoni MR. Molecular dynamics simulations of human L-asparaginase1: Insights into structural determinants of enzymatic activity. Journal of Molecular Graphics & Modelling. 109: 108007. PMID 34461521 DOI: 10.1016/j.jmgm.2021.108007   
2021 Zhang YX, Yang JW, Wu YY, Hu XQ, Zhang HB. The stability improvement of dextransucrase by artificial extension modification of the V domain of the enzyme. Enzyme and Microbial Technology. 151: 109919. PMID 34649690 DOI: 10.1016/j.enzmictec.2021.109919   
2021 Tegl G, Rahfeld P, Ostmann K, Hanson J, Withers SG. Discovery of β--acetylglucosaminidases from screening metagenomic libraries and their use as thioglycoligase mutants. Organic & Biomolecular Chemistry. PMID 34622263 DOI: 10.1039/d1ob01246k   
2021 Arif T, Currie MJ, Dobson RCJ, Newson HL, Poonthiyil V, Fairbanks AJ, North RA, Rendle PM. Synthesis of N-acetylmannosamine-6-phosphate derivatives to investigate the mechanism of N-acetylmannosamine-6-phosphate 2-epimerase. Carbohydrate Research. 510: 108445. PMID 34607125 DOI: 10.1016/j.carres.2021.108445   
2021 Morgan GL, Li K, Crawford DM, Aubé J, Li B. Enzymatic Synthesis of Diverse Heterocycles by a Noncanonical Nonribosomal Peptide Synthetase. Acs Chemical Biology. PMID 34767712 DOI: 10.1021/acschembio.1c00623   
2021 Narang PK, Dey J, Mahapatra SR, Roy R, Kushwaha GS, Misra N, Suar M, Raina V. Genome-based identification and comparative analysis of enzymes for carotenoid biosynthesis in microalgae. World Journal of Microbiology & Biotechnology. 38: 8. PMID 34837551 DOI: 10.1007/s11274-021-03188-y   
2021 Ahn WC, An Y, Song KM, Park KH, Lee SJ, Oh BH, Park JT, Woo EJ. Dimeric architecture of maltodextrin glucosidase (MalZ) provides insights into the substrate recognition and hydrolysis mechanism. Biochemical and Biophysical Research Communications. 586: 49-54. PMID 34826700 DOI: 10.1016/j.bbrc.2021.11.070   
2021 Yu L, Zhou W, She Y, Ma H, Cai YS, Jiang M, Deng Z, Price NPJ, Chen W. Efficient biosynthesis of nucleoside cytokinin angustmycin A containing an unusual sugar system. Nature Communications. 12: 6633. PMID 34789759 DOI: 10.1038/s41467-021-26928-y   
2021 Dohnálek J, Dušková J, Tishchenko G, Kolenko P, Skálová T, Novák P, Fejfarová K, Šimůnek J. Chitinase Chit62J4 Essential for Chitin Processing by Human Microbiome Bacterium J4. Molecules (Basel, Switzerland). 26. PMID 34641521 DOI: 10.3390/molecules26195978   
2021 Dey D, Dhar D, Fortunato H, Obata D, Tanaka A, Tanaka R, Basu S, Ito H. Insights into the structure and function of the rate-limiting enzyme of chlorophyll degradation through analysis of a bacterial Mg-dechelatase homolog. Computational and Structural Biotechnology Journal. 19: 5333-5347. PMID 34745453 DOI: 10.1016/j.csbj.2021.09.023   
2021 Pan X, Yang J, Xie P, Zhang J, Ke F, Guo X, Liang M, Liu L, Wang Q, Gao X. Enhancement of Activity and Thermostability of Keratinase From CCTCC AB2013184 by Directed Evolution With Noncanonical Amino Acids. Frontiers in Bioengineering and Biotechnology. 9: 770907. PMID 34733836 DOI: 10.3389/fbioe.2021.770907   
2021 Little RF, Hertweck C. Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis. Natural Product Reports. PMID 34622896 DOI: 10.1039/d1np00035g   
2021 Li G, Patel K, Zhang Y, Pugmire J, Ding Y, Bruner SD. Structural and biochemical studies of an iterative ribosomal peptide macrocyclase. Proteins. PMID 34664307 DOI: 10.1002/prot.26264   
2021 Valenzuela-Chavira I, Corona-Martinez DO, Garcia-Orozco KD, Beltran-Torres M, Sanchez-Lopez F, Arvizu-Flores AA, Sugich-Miranda R, Lopez-Zavala AA, Robles-Zepeda RE, Islas-Osuna MA, Ochoa-Leyva A, Toney MD, Serrano-Posada H, Sotelo-Mundo RR. A Novel Glutathione -Transferase Gtt2 Class (VpGSTT2) Is Found in the Genome of the AHPND/EMS Shrimp Pathogen. Toxins. 13. PMID 34564668 DOI: 10.3390/toxins13090664   
2021 Pei X, Wang J, Zheng H, Xiao Q, Wang A, Su W. Catalytically active inclusion bodies (CatIBs) induced by terminally attached self-assembling coiled-coil domains: To enhance the stability of (R)-hydroxynitrile lyase. Enzyme and Microbial Technology. 153: 109915. PMID 34670185 DOI: 10.1016/j.enzmictec.2021.109915   
2021 Lewis JK, Jochimsen AS, Lefave SJ, Young AP, Kincannon WM, Roberts AG, Kieber-Emmons MT, Bandarian V. New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products. Biochemistry. PMID 34730336 DOI: 10.1021/acs.biochem.1c00469   
2021 Wang J, Anderson K, Yang E, He L, Lidstrom ME. Enzyme engineering and testing of a formate reduction pathway. Synthetic Biology (Oxford, England). 6: ysab020. PMID 34651085 DOI: 10.1093/synbio/ysab020   
2021 Vélez-Mercado MI, Talavera-Caro AG, Escobedo-Uribe KM, Sánchez-Muñoz S, Luévanos-Escareño MP, Hernández-Terán F, Alvarado A, Balagurusamy N. Bioconversion of Lignocellulosic Biomass into Value Added Products under Anaerobic Conditions: Insight into Proteomic Studies. International Journal of Molecular Sciences. 22. PMID 34830131 DOI: 10.3390/ijms222212249   
2021 de la Fuente M, Lombardero L, Gómez-González A, Solari C, Angulo-Barturen I, Acera A, Vecino E, Astigarraga E, Barreda-Gómez G. Enzyme Therapy: Current Challenges and Future Perspectives. International Journal of Molecular Sciences. 22. PMID 34502086 DOI: 10.3390/ijms22179181   
2021 Nakamura S, Nihira T, Kurata R, Nakai H, Funane K, Park EY, Miyazaki T. Structure of a bacterial α-1,2-glucosidase defines mechanisms of hydrolysis and substrate specificity in GH65 family hydrolases. The Journal of Biological Chemistry. 101366. PMID 34728215 DOI: 10.1016/j.jbc.2021.101366   
2021 Yu Q, Xie L, Li Y, Bai L, Zhao YL, Wei D, Shi T. Exploring the Molecular Basis of Substrate and Product Selectivities of Nocardicin Bifunctional Thioesterase. Interdisciplinary Sciences, Computational Life Sciences. PMID 34699036 DOI: 10.1007/s12539-021-00482-z   
2021 Huang J, Liu Z, Bloomer BJ, Clark DS, Mukhopadhyay A, Keasling JD, Hartwig JF. Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme. Nature Chemistry. PMID 34650235 DOI: 10.1038/s41557-021-00801-3   
2021 Luo B, Jin MM, Li X, Makunga NP, Hu X. Yeast Surface Display for Biosynthetic Pathway Reconstruction. Acs Synthetic Biology. PMID 34724381 DOI: 10.1021/acssynbio.1c00175   
2021 Kumari M, Padhi S, Sharma S, Phukon LC, Singh SP, Rai AK. Biotechnological potential of psychrophilic microorganisms as the source of cold-active enzymes in food processing applications. 3 Biotech. 11: 479. PMID 34790503 DOI: 10.1007/s13205-021-03008-y   
2021 Maruyama S, Sawano K, Amaki S, Suzuki T, Narita S, Kimura K, Arakawa T, Yamada C, Ito Y, Dohmae N, Fujita K, Ishiwata A, Fushinobu S. Substrate complex structure, active site labeling and catalytic role of the zinc ion in cysteine glycosidase. Glycobiology. PMID 34735571 DOI: 10.1093/glycob/cwab103   
2021 Azimi F, Azizian H, Najafi M, Khodarahmi G, Saghaei L, Hassanzadeh M, Ghasemi JB, Faramarzi MA, Larijani B, Hassanzadeh F, Mahdavi M. Design, synthesis, biological evaluation, and molecular modeling studies of pyrazole-benzofuran hybrids as new α-glucosidase inhibitor. Scientific Reports. 11: 20776. PMID 34675367 DOI: 10.1038/s41598-021-99899-1   
2021 Griffiths WA, Spencer KD, Thoden JB, Holden HM. Biochemical Investigation of an N-acetyltransferase from Helicobacter pullorum. Protein Science : a Publication of the Protein Society. PMID 34651380 DOI: 10.1002/pro.4207   
2021 Park W, Son HF, Lee D, Kim IK, Kim KJ. Crystal Structure and Functional Characterization of the Bifunctional -(5'-Phosphoribosyl)anthranilate Isomerase-indole-3-glycerol-phosphate Synthase from . Journal of Agricultural and Food Chemistry. PMID 34657425 DOI: 10.1021/acs.jafc.1c05132   
2021 Moore SJ, Tosi T, Bell D, Hleba YB, Polizzi KM, Freemont PS. High-yield 'one-pot' biosynthesis of raspberry ketone, a high-value fine chemical. Synthetic Biology (Oxford, England). 6: ysab021. PMID 34712844 DOI: 10.1093/synbio/ysab021   
2021 Shi Q, Chen Y, Li X, Dong H, Chen C, Zhong Z, Yang C, Liu G, Su D. The tetrameric assembly of 2-aminomuconic 6-semialdehyde dehydrogenase is a functional requirement of cofactor NAD binding. Environmental Microbiology. PMID 34806815 DOI: 10.1111/1462-2920.15840   
2021 Erickson E, Shakespeare TJ, Bratti F, Buss BL, Graham R, Hawkins MA, König G, Michener WE, Miscall J, Ramirez KJ, Rorrer NA, Zahn M, Pickford AR, McGeehan JE, Beckham G. Comparative performance of PETase as a function of reaction conditions, substrate properties, and product accumulation. Chemsuschem. PMID 34587366 DOI: 10.1002/cssc.202101932   
2021 Boddington K, Soubeyrand E, Van Gelder K, Casaretto JA, Perrin C, Forrester TJB, Parry C, Al-Abdul-Wahid MS, Jentsch NG, Magolan J, Bozzo GG, Kimber MS, Rothstein SJ, Akhtar TA. Bibenzyl synthesis in Cannabis sativa L. The Plant Journal : For Cell and Molecular Biology. PMID 34786774 DOI: 10.1111/tpj.15588   
2021 Sambyal K, Singh RV. Exploitation of E. coli for the production of penicillin G amidase: a tool for the synthesis of semisynthetic β-lactam antibiotics. Journal, Genetic Engineering & Biotechnology. 19: 156. PMID 34652570 DOI: 10.1186/s43141-021-00263-7   
2021 Chirgadze YN, Battaile KP, Likhachev IV, Balabaev NK, Gordon RD, Romanov V, Lin A, Karisch R, Lam R, Ruzanov M, Brazhnikov EV, Pai EF, Neel BG, Chirgadze NY. Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058. Journal of Biomolecular Structure & Dynamics. 1-10. PMID 34705594 DOI: 10.1080/07391102.2021.1994879   
2021 Qu G, Bi Y, Liu B, Li J, Han X, Liu W, Jiang Y, Qin Z, Sun Z. Unlocking the Stereoselectivity and Substrate Acceptance of Enzymes: Proline-Induced Loop Engineering Test. Angewandte Chemie (International Ed. in English). PMID 34658118 DOI: 10.1002/anie.202110793   
2021 Ko JA, Kim SY, Ahn HS, Go JG, Ryu YB, Lee WS, Wee YJ, Park JS, Kim D, Kim YM. Characterization of a lactic acid bacterium-derived β-glucosidase for the production of rubusoside from stevioside. Enzyme and Microbial Technology. 153: 109939. PMID 34798448 DOI: 10.1016/j.enzmictec.2021.109939   
2021 Zhao L, Chen Z, Lin S, Wu T, Yu S, Huo YX. Biosynthesis of Isobutyraldehyde Through the Establishment of a One-Step Self-Assembly-Based Immobilization Strategy. Journal of Agricultural and Food Chemistry. PMID 34818887 DOI: 10.1021/acs.jafc.1c05387   
2021 Wang L, Cao K, Pedroso MM, Wu B, Gao Z, He B, Schenk G. Sequence- and structure-guided improvement of the catalytic performance of a GH11 family xylanase from Bacillus subtilis. The Journal of Biological Chemistry. 297: 101262. PMID 34600889 DOI: 10.1016/j.jbc.2021.101262   
2021 Liu Q, Liu Y, Li G, Savolainen O, Chen Y, Nielsen J. De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories. Nature Communications. 12: 6085. PMID 34667183 DOI: 10.1038/s41467-021-26361-1   
2021 Gavgani HN, Fawaz R, Ehyaei N, Walls D, Pawlowski K, Fulgos R, Park S, Assar Z, Ghanbarpour A, Geiger JH. A structural explanation for the mechanism and specificity of plant branching enzymes I and IIb. The Journal of Biological Chemistry. 101395. PMID 34762912 DOI: 10.1016/j.jbc.2021.101395   
2021 Gu X, Fu L, Pan A, Gui Y, Zhang Q, Li J. Multifunctional alkalophilic α-amylase with diverse raw seaweed degrading activities. Amb Express. 11: 139. PMID 34669086 DOI: 10.1186/s13568-021-01300-x   
2021 Chen Y, Wu J, Yu D, Du X. Advances in steroidal saponins biosynthesis. Planta. 254: 91. PMID 34617240 DOI: 10.1007/s00425-021-03732-y   
2021 Wang ZQ, Song H, Koleski EJ, Hara N, Park DS, Kumar G, Min Y, Dauenhauer PJ, Chang MCY. A dual cellular-heterogeneous catalyst strategy for the production of olefins from glucose. Nature Chemistry. PMID 34811478 DOI: 10.1038/s41557-021-00820-0   
2021 Hansen AL, Koivisto JM, Simonsen S, Dong Z, Crehuet R, Hansen DK, Willemoës M. Identification of a Catalytic Nucleophile-Activating Network in the endoαAcetylgalactosaminidase of Family GH101. Biochemistry. PMID 34694774 DOI: 10.1021/acs.biochem.1c00596