David R. Liu - Publications

Affiliations: 
Chemistry and Chemical Biology Harvard University, Cambridge, MA, United States 
Area:
The Chemistry of Molecular Evolution
Website:
http://evolve.harvard.edu/drlcv.htm

198 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Tao Y, Lamas V, Du W, Zhu W, Li Y, Whittaker MN, Zuris JA, Thompson DB, Rameshbabu AP, Shu Y, Gao X, Hu JH, Pei C, Kong WJ, Liu X, ... ... Liu DR, et al. Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo. Nature Communications. 14: 4928. PMID 37582836 DOI: 10.1038/s41467-023-40476-7  0.363
2022 Neugebauer ME, Hsu A, Arbab M, Krasnow NA, McElroy AN, Pandey S, Doman JL, Huang TP, Raguram A, Banskota S, Newby GA, Tolar J, Osborn MJ, Liu DR. Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity. Nature Biotechnology. PMID 36357719 DOI: 10.1038/s41587-022-01533-6  0.811
2022 Peterson AA, Rangwala AM, Thakur MK, Ward PS, Hung C, Outhwaite IR, Chan AI, Usanov DL, Mootha VK, Seeliger MA, Liu DR. Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nature Chemical Biology. PMID 36163383 DOI: 10.1038/s41589-022-01116-1  0.665
2022 Huang TP, Heins ZJ, Miller SM, Wong BG, Balivada PA, Wang T, Khalil AS, Liu DR. High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs. Nature Biotechnology. PMID 36076084 DOI: 10.1038/s41587-022-01410-2  0.622
2021 Anzalone AV, Gao XD, Podracky CJ, Nelson AT, Koblan LW, Raguram A, Levy JM, Mercer JAM, Liu DR. Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing. Nature Biotechnology. PMID 34887556 DOI: 10.1038/s41587-021-01133-w  0.313
2021 Morrison MS, Wang T, Raguram A, Hemez C, Liu DR. Author Correction: Disulfide-compatible phage-assisted continuous evolution in the periplasmic space. Nature Communications. 12: 6800. PMID 34789771 DOI: 10.1038/s41467-021-27102-0  0.546
2021 Morrison MS, Wang T, Raguram A, Hemez C, Liu DR. Disulfide-compatible phage-assisted continuous evolution in the periplasmic space. Nature Communications. 12: 5959. PMID 34645844 DOI: 10.1038/s41467-021-26279-8  0.597
2021 Newby GA, Yen JS, Woodard KJ, Mayuranathan T, Lazzarotto CR, Li Y, Sheppard-Tillman H, Porter SN, Yao Y, Mayberry K, Everette KA, Jang Y, Podracky CJ, Thaman E, Lechauve C, ... ... Liu DR, et al. Base editing of haematopoietic stem cells rescues sickle cell disease in mice. Nature. PMID 34079130 DOI: 10.1038/s41586-021-03609-w  0.59
2021 Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, et al. The NIH Somatic Cell Genome Editing program. Nature. 592: 195-204. PMID 33828315 DOI: 10.1038/s41586-021-03191-1  0.605
2020 Miller SM, Wang T, Liu DR. Phage-assisted continuous and non-continuous evolution. Nature Protocols. 15: 4101-4127. PMID 33199872 DOI: 10.1038/s41596-020-00410-3  0.606
2020 Angrist M, Barrangou R, Baylis F, Brokowski C, Burgio G, Caplan A, Chapman CR, Church GM, Cook-Deegan R, Cwik B, Doudna JA, Evans JH, Greely HT, Hercher L, Hurlbut JB, ... ... Liu DR, et al. Reactions to the National Academies/Royal Society Report on . The Crispr Journal. 3: 332-349. PMID 33095048 DOI: 10.1089/crispr.2020.29106.man  0.359
2020 Lapinaite A, Knott GJ, Palumbo CM, Lin-Shiao E, Richter MF, Zhao KT, Beal PA, Liu DR, Doudna JA. DNA capture by a CRISPR-Cas9-guided adenine base editor. Science (New York, N.Y.). 369: 566-571. PMID 32732424 DOI: 10.1126/Science.Abb1390  0.396
2020 Reidenbach AG, Mesleh MF, Casalena D, Vallabh SM, Dahlin JL, Leed AJ, Chan AI, Usanov DL, Yehl JB, Lemke CT, Campbell AJ, Shah RN, Shrestha OK, Sacher JR, Rangel VL, ... ... Liu DR, et al. Multimodal small-molecule screening for human prion protein binders. The Journal of Biological Chemistry. PMID 32723867 DOI: 10.1074/Jbc.Ra120.014905  0.682
2020 Mok BY, de Moraes MH, Zeng J, Bosch DE, Kotrys AV, Raguram A, Hsu F, Radey MC, Peterson SB, Mootha VK, Mougous JD, Liu DR. A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing. Nature. PMID 32641830 DOI: 10.1038/S41586-020-2477-4  0.409
2020 Wilson C, Chen PJ, Miao Z, Liu DR. Programmable mA modification of cellular RNAs with a Cas13-directed methyltransferase. Nature Biotechnology. PMID 32601430 DOI: 10.1038/S41587-020-0572-6  0.355
2020 Morrison MS, Podracky CJ, Liu DR. The developing toolkit of continuous directed evolution. Nature Chemical Biology. 16: 610-619. PMID 32444838 DOI: 10.1038/S41589-020-0532-Y  0.315
2020 Richter MF, Zhao KT, Eton E, Lapinaite A, Newby GA, Thuronyi BW, Wilson C, Koblan LW, Zeng J, Bauer DE, Doudna JA, Liu DR. Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity. Nature Biotechnology. PMID 32433547 DOI: 10.1038/S41587-020-0453-Z  0.366
2020 Lin Q, Zong Y, Xue C, Wang S, Jin S, Zhu Z, Wang Y, Anzalone AV, Raguram A, Doman JL, Liu DR, Gao C. Prime genome editing in rice and wheat. Nature Biotechnology. 38: 582-585. PMID 32393904 DOI: 10.1038/S41587-020-0455-X  0.312
2020 Jiang T, Henderson JM, Coote K, Cheng Y, Valley HC, Zhang XO, Wang Q, Rhym LH, Cao Y, Newby GA, Bihler H, Mense M, Weng Z, Anderson DG, McCaffrey AP, ... Liu DR, et al. Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope. Nature Communications. 11: 1979. PMID 32332735 DOI: 10.1038/S41467-020-15892-8  0.358
2020 Miller SM, Wang T, Randolph PB, Arbab M, Shen MW, Huang TP, Matuszek Z, Newby GA, Rees HA, Liu DR. Continuous evolution of SpCas9 variants compatible with non-G PAMs. Nature Biotechnology. PMID 32042170 DOI: 10.1038/S41587-020-0412-8  0.675
2020 Doman JL, Raguram A, Newby GA, Liu DR. Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors. Nature Biotechnology. PMID 32042165 DOI: 10.1038/S41587-020-0414-6  0.372
2020 Kim HK, Lee S, Kim Y, Park J, Min S, Choi JW, Huang TP, Yoon S, Liu DR, Kim HH. High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells. Nature Biomedical Engineering. PMID 31937939 DOI: 10.1038/S41551-019-0505-1  0.332
2019 Song CQ, Jiang T, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR, Yin H, Xue W. Adenine base editing in an adult mouse model of tyrosinaemia. Nature Biomedical Engineering. PMID 31740768 DOI: 10.1038/S41551-019-0357-8  0.351
2019 Anzalone AV, Randolph PB, Davis JR, Sousa AA, Koblan LW, Levy JM, Chen PJ, Wilson C, Newby GA, Raguram A, Liu DR. Search-and-replace genome editing without double-strand breaks or donor DNA. Nature. PMID 31634902 DOI: 10.1038/S41586-019-1711-4  0.393
2019 Usanov DL, Chan AI, Maianti JP, Liu DR. Author Correction: Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules. Nature Chemistry. PMID 31576016 DOI: 10.1038/S41557-019-0360-4  0.797
2019 Osborn MJ, Newby GA, McElroy AN, Knipping F, Nielsen SC, Riddle MJ, Xia L, Chen W, Eide CR, Webber BR, Wandall HH, Dabelsteen S, Blazar BR, Liu DR, Tolar J. Base editor correction of COL7A1 in recessive dystrophic epidermolysis bullosa patient-derived fibroblasts and iPSCs. The Journal of Investigative Dermatology. PMID 31437443 DOI: 10.1016/J.Jid.2019.07.701  0.367
2019 Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR. Continuous evolution of base editors with expanded target compatibility and improved activity. Nature Biotechnology. PMID 31332326 DOI: 10.1038/S41587-019-0193-0  0.389
2019 Kim YB, Zhao KT, Thompson DB, Liu DR. An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells. Nature Communications. 10: 2905. PMID 31266953 DOI: 10.1038/S41467-019-10828-3  0.337
2019 Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR. Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors. Nature Biotechnology. PMID 31110355 DOI: 10.1038/S41587-019-0134-Y  0.327
2019 Rees HA, Yeh WH, Liu DR. Development of hRad51-Cas9 nickase fusions that mediate HDR without double-stranded breaks. Nature Communications. 10: 2212. PMID 31101808 DOI: 10.1038/S41467-019-09983-4  0.382
2019 Rees HA, Wilson C, Doman JL, Liu DR. Analysis and minimization of cellular RNA editing by DNA adenine base editors. Science Advances. 5: eaax5717. PMID 31086823 DOI: 10.1126/Sciadv.Aax5717  0.423
2019 Maianti JP, Tan GA, Vetere A, Welsh AJ, Wagner BK, Seeliger MA, Liu DR. Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nature Chemical Biology. PMID 31086331 DOI: 10.1038/S41589-019-0271-0  0.759
2019 Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dančík V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, et al. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9. Cell. 177: 1067-1079.e19. PMID 31051099 DOI: 10.1016/J.Cell.2019.04.009  0.371
2019 Bessen JL, Afeyan LK, Dančík V, Koblan LW, Thompson DB, Leichner C, Clemons PA, Liu DR. High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases. Nature Communications. 10: 1937. PMID 31028261 DOI: 10.1038/S41467-019-09987-0  0.424
2019 Roth T, Woolston B, Stephanopoulos G, Liu DR. Phage-assisted evolution of Bacillus methanolicus methanol dehydrogenase 2. Acs Synthetic Biology. PMID 30856338 DOI: 10.1021/Acssynbio.8B00481  0.315
2019 Lichtor PA, Chen Z, Elowe NH, Chen JC, Liu DR. Side chain determinants of biopolymer function during selection and replication. Nature Chemical Biology. PMID 30742124 DOI: 10.1038/S41589-019-0229-2  0.328
2019 Lee HK, Willi M, Smith HE, Miller SM, Liu DR, Liu C, Hennighausen L. Simultaneous targeting of linked loci in mouse embryos using base editing. Scientific Reports. 9: 1662. PMID 30733567 DOI: 10.1038/S41598-018-33533-5  0.357
2018 Lee HK, Willi M, Miller SM, Kim S, Liu C, Liu DR, Hennighausen L. Targeting fidelity of adenine and cytosine base editors in mouse embryos. Nature Communications. 9: 4804. PMID 30442934 DOI: 10.1038/S41467-018-07322-7  0.369
2018 Shen MW, Arbab M, Hsu JY, Worstell D, Culbertson SJ, Krabbe O, Cassa CA, Liu DR, Gifford DK, Sherwood RI. Predictable and precise template-free CRISPR editing of pathogenic variants. Nature. PMID 30405244 DOI: 10.1038/S41586-018-0686-X  0.354
2018 Rees HA, Liu DR. Base editing: precision chemistry on the genome and transcriptome of living cells. Nature Reviews. Genetics. PMID 30323312 DOI: 10.1038/S41576-018-0059-1  0.427
2018 Harmand T, Bousbaine D, Chan AI, Zhang X, Liu DR, Tam JP, Ploegh HL. One-pot dual labeling of an IgG 1 and preparation of C-to-C fusion proteins through a combination of Sortase A and Butelase 1. Bioconjugate Chemistry. PMID 30231608 DOI: 10.1021/Acs.Bioconjchem.8B00563  0.342
2018 Wang T, Badran AH, Huang TP, Liu DR. Continuous directed evolution of proteins with improved soluble expression. Nature Chemical Biology. PMID 30127387 DOI: 10.1038/S41589-018-0121-5  0.641
2018 Yeh WH, Chiang H, Rees HA, Edge ASB, Liu DR. In vivo base editing of post-mitotic sensory cells. Nature Communications. 9: 2184. PMID 29872041 DOI: 10.1038/S41467-018-04580-3  0.334
2018 Koblan LW, Doman JL, Wilson C, Levy JM, Tay T, Newby GA, Maianti JP, Raguram A, Liu DR. Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction. Nature Biotechnology. PMID 29813047 DOI: 10.1038/Nbt.4172  0.772
2018 Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR. Publisher Correction: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature. PMID 29720650 DOI: 10.1038/S41586-018-0070-X  0.313
2018 Usanov DL, Chan AI, Maianti JP, Liu DR. Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules. Nature Chemistry. PMID 29610462 DOI: 10.1038/S41557-018-0033-8  0.814
2018 Hu JH, Miller SM, Geurts MH, Tang W, Chen L, Sun N, Zeina CM, Gao X, Rees HA, Lin Z, Liu DR. Evolved Cas9 variants with broad PAM compatibility and high DNA specificity. Nature. PMID 29512652 DOI: 10.1038/Nature26155  0.569
2018 Chen Z, Lichtor PA, Berliner AP, Chen JC, Liu DR. Evolution of sequence-defined highly functionalized nucleic acid polymers. Nature Chemistry. PMID 29507367 DOI: 10.1038/S41557-018-0008-9  0.335
2018 Tang W, Liu DR. Rewritable multi-event analog recording in bacterial and mammalian cells. Science (New York, N.Y.). PMID 29449507 DOI: 10.1126/Science.Aap8992  0.317
2017 Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, ... ... Liu DR, et al. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. PMID 29258297 DOI: 10.1038/Nature25164  0.479
2017 Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature. PMID 29160308 DOI: 10.1038/Nature24644  0.411
2017 Packer MS, Rees HA, Liu DR. Phage-assisted continuous evolution of proteases with altered substrate specificity. Nature Communications. 8: 956. PMID 29038472 DOI: 10.1038/S41467-017-01055-9  0.334
2017 Suzuki T, Miller C, Guo LT, Ho JML, Bryson DI, Wang YS, Liu DR, Söll D. Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase. Nature Chemical Biology. PMID 29035363 DOI: 10.1038/Nchembio.2497  0.306
2017 Bryson DI, Fan C, Guo LT, Miller C, Söll D, Liu DR. Continuous directed evolution of aminoacyl-tRNA synthetases. Nature Chemical Biology. PMID 29035361 DOI: 10.1038/Nchembio.2474  0.365
2017 Komor AC, Badran AH, Liu DR. Editing the Genome Without Double-Stranded DNA Breaks. Acs Chemical Biology. PMID 28957631 DOI: 10.1021/Acschembio.7B00710  0.393
2017 Woolston BM, Roth T, Kohale I, Liu D, Stephanopoulos G. Development of a Formaldehyde Biosensor with Application to Synthetic Methylotrophy. Biotechnology and Bioengineering. PMID 28921510 DOI: 10.1002/Bit.26455  0.31
2017 Komor AC, Zhao KT, Packer MS, Gaudelli NM, Waterbury AL, Koblan LW, Kim YB, Badran AH, Liu DR. Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity. Science Advances. 3: eaao4774. PMID 28875174 DOI: 10.1126/Sciadv.Aao4774  0.334
2017 Chan AI, McGregor LM, Jain T, Liu DR. Discovery of a covalent kinase inhibitor from a DNA-encoded small-molecule library X protein library selection. Journal of the American Chemical Society. PMID 28689404 DOI: 10.1021/Jacs.7B04880  0.432
2017 Tang W, Hu JH, Liu DR. Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation. Nature Communications. 8: 15939. PMID 28656978 DOI: 10.1038/Ncomms15939  0.346
2017 Rees HA, Komor AC, Yeh WH, Caetano-Lopes J, Warman M, Edge ASB, Liu DR. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery. Nature Communications. 8: 15790. PMID 28585549 DOI: 10.1038/Ncomms15790  0.437
2017 Kim YB, Komor AC, Levy JM, Packer MS, Zhao KT, Liu DR. Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions. Nature Biotechnology. PMID 28191901 DOI: 10.1038/Nbt.3803  0.413
2017 Mouw K, Lazaro J, Damish A, Reznichenko E, Frazier Z, Liu D, Kim J, Polak P, Garraway L, Getz G, Rosenberg J, Allen EV, D'Andrea A. Abstract PR18: Somatic ERCC2 mutations, nucleotide excision repair (NER) function, and cisplatin response in muscle-invasive bladder cancer (MIBC) Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-Pr18  0.302
2016 Komor AC, Badran AH, Liu DR. CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell. PMID 27866654 DOI: 10.1016/J.Cell.2016.10.044  0.374
2016 Aleem SU, Georghiou G, Kleiner RE, Guja KE, Craddock BP, Lyczek A, Chan AI, Garcia-Diaz M, Miller WT, Liu DR, Seeliger MA. Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles. Cell Chemical Biology. PMID 27593110 DOI: 10.1016/J.Chembiol.2016.07.017  0.682
2016 Chaikind B, Bessen JL, Thompson DB, Hu JH, Liu DR. A programmable Cas9-serine recombinase fusion protein that operates on DNA sequences in mammalian cells. Nucleic Acids Research. PMID 27515511 DOI: 10.1093/Nar/Gkw707  0.436
2016 Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature. PMID 27096365 DOI: 10.1038/Nature17946  0.422
2016 Hu JH, Davis KM, Liu DR. Chemical Biology Approaches to Genome Editing: Understanding, Controlling, and Delivering Programmable Nucleases. Cell Chemical Biology. 23: 57-73. PMID 26933736 DOI: 10.1016/J.Chembiol.2015.12.009  0.433
2016 Wang M, Zuris JA, Meng F, Rees H, Sun S, Deng P, Han Y, Gao X, Pouli D, Wu Q, Georgakoudi I, Liu DR, Xu Q. Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles. Proceedings of the National Academy of Sciences of the United States of America. PMID 26929348 DOI: 10.1073/Pnas.1520244113  0.508
2016 Bernstein BE, Gray N, Boyd MR, Corcoran RB, Stone RM, Armand P, Sykes DB, Gopal R, Gala MK, Liu D, Tothova Z, Nodelman O, Maus MV, Wu CJ. Chabner Colloquium: Answering the Big Questions in Cancer Research & 2016 STO Annual Meeting Oncologist. 21. DOI: 10.1634/Theoncologist.2016-Ma-1  0.375
2016 Salem K, Park J, Freymond C, Capelletti M, Huynh D, Sacco A, Perilla Glen A, Caola AM, Henrick P, Van Allen E, Liu D, Roccaro AM, Munshi NC, Getz G, Ghobrial IM, et al. Whole Exome Sequencing and Targeted Sequencing Reveal the Heterogeneity of Genomic Evolution and Mutational Profile in Smoldering Multiple Myeloma Blood. 128: 237-237. DOI: 10.1182/Blood.V128.22.237.237  0.326
2015 Glavan AC, Niu J, Chen Z, Güder F, Cheng CM, Liu DR, Whitesides GM. Analytical Devices Based on Direct Synthesis of DNA on Paper. Analytical Chemistry. PMID 26607489 DOI: 10.1021/Acs.Analchem.5B02822  0.587
2015 Li M, Tao Y, Shu Y, LaRochelle JR, Steinauer A, Thompson D, Schepartz A, Chen ZY, Liu DR. Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo. Journal of the American Chemical Society. PMID 26465072 DOI: 10.1021/Jacs.5B05694  0.33
2015 Badran AH, Liu DR. Development of potent in vivo mutagenesis plasmids with broad mutational spectra. Nature Communications. 6: 8425. PMID 26443021 DOI: 10.1038/Ncomms9425  0.312
2015 Hubbard BP, Badran AH, Zuris JA, Guilinger JP, Davis KM, Chen L, Tsai SQ, Sander JD, Joung JK, Liu DR. Continuous directed evolution of DNA-binding proteins to improve TALEN specificity. Nature Methods. 12: 939-42. PMID 26258293 DOI: 10.1038/Nmeth.3515  0.814
2015 Packer MS, Liu DR. Methods for the directed evolution of proteins. Nature Reviews. Genetics. 16: 379-94. PMID 26055155 DOI: 10.1038/Nrg3927  0.355
2015 Bertozzi CR, Stockwell BR, Kubicek S, Dickinson BC, Chang CJ, Schultz C, Silver PA, Gestwicki JE, Chiosis G, Chattopadhyay A, Butcher RA, Park SB, Shoichet BK, Flitsch SL, Zhang J, ... Liu DR, et al. Voices of chemical biology Nature Chemical Biology. 11: 378-379. PMID 25978987 DOI: 10.1038/Nchembio.1820  0.706
2015 Davis KM, Pattanayak V, Thompson DB, Zuris JA, Liu DR. Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nature Chemical Biology. 11: 316-8. PMID 25848930 DOI: 10.1038/Nchembio.1793  0.747
2015 Chan AI, McGregor LM, Liu DR. Novel selection methods for DNA-encoded chemical libraries. Current Opinion in Chemical Biology. 26: 55-61. PMID 25723146 DOI: 10.1016/J.Cbpa.2015.02.010  0.399
2015 Kim W, Haller C, Dai E, Wang X, Hagemeyer CE, Liu DR, Peter K, Chaikof EL. Targeted antithrombotic protein micelles. Angewandte Chemie (International Ed. in English). 54: 1461-5. PMID 25504546 DOI: 10.1002/Anie.201408529  0.346
2015 Badran AH, Liu DR. In vivo continuous directed evolution. Current Opinion in Chemical Biology. 24: 1-10. PMID 25461718 DOI: 10.1016/J.Cbpa.2014.09.040  0.333
2015 Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY, Liu DR. Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo. Nature Biotechnology. 33: 73-80. PMID 25357182 DOI: 10.1038/Nbt.3081  0.807
2015 Dickinson BC, Packer MS, Badran AH, Liu DR. A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations Nature Communications. 5. DOI: 10.1038/ncomms6352  0.512
2014 Pattanayak V, Guilinger JP, Liu DR. Determining the specificities of TALENs, Cas9, and other genome-editing enzymes. Methods in Enzymology. 546: 47-78. PMID 25398335 DOI: 10.1016/B978-0-12-801185-0.00003-9  0.802
2014 Dickinson BC, Packer MS, Badran AH, Liu DR. A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations. Nature Communications. 5: 5352. PMID 25355134 DOI: 10.1038/Ncomms6352  0.579
2014 McDonald RI, Guilinger JP, Mukherji S, Curtis EA, Lee WI, Liu DR. Electrophilic activity-based RNA probes reveal a self-alkylating RNA for RNA labeling. Nature Chemical Biology. 10: 1049-54. PMID 25306441 DOI: 10.1038/Nchembio.1655  0.791
2014 Dorr BM, Ham HO, An C, Chaikof EL, Liu DR. Reprogramming the specificity of sortase enzymes. Proceedings of the National Academy of Sciences of the United States of America. 111: 13343-8. PMID 25187567 DOI: 10.1073/Pnas.1411179111  0.33
2014 Maianti JP, McFedries A, Foda ZH, Kleiner RE, Du XQ, Leissring MA, Tang WJ, Charron MJ, Seeliger MA, Saghatelian A, Liu DR. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. 511: 94-8. PMID 24847884 DOI: 10.1038/Nature13297  0.757
2014 Curtis EA, Liu DR. A naturally occurring, noncanonical GTP aptamer made of simple tandem repeats. Rna Biology. 11: 682-92. PMID 24824832 DOI: 10.4161/Rna.28798  0.321
2014 Guilinger JP, Thompson DB, Liu DR. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification Nature Biotechnology. 32: 577-582. PMID 24770324 DOI: 10.1038/Nbt.2909  0.821
2014 Guilinger JP, Pattanayak V, Reyon D, Tsai SQ, Sander JD, Joung JK, Liu DR. Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity Nature Methods. 11: 429-435. PMID 24531420 DOI: 10.1038/Nmeth.2845  0.815
2014 McGregor LM, Jain T, Liu DR. Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates. Journal of the American Chemical Society. 136: 3264-70. PMID 24495225 DOI: 10.1021/Ja412934T  0.425
2014 Carlson JC, Badran AH, Guggiana-Nilo DA, Liu DR. Negative selection and stringency modulation in phage-assisted continuous evolution. Nature Chemical Biology. 10: 216-22. PMID 24487694 DOI: 10.1038/Nchembio.1453  0.639
2014 Liu DR. Abstract SY05-04: Biological discovery and therapeutic insight from DNA-templated macrocycle libraries Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Sy05-04  0.428
2014 Pattanayak V, Guilinger JP, Liu DR. Determining the specificities of TALENs, cas9, and other genome-editing enzymes Methods in Enzymology. 546: 47-78. DOI: 10.1016/B978-0-12-801185-0.00003-9  0.768
2013 Sander JD, Ramirez CL, Linder SJ, Pattanayak V, Shoresh N, Ku M, Foden JA, Reyon D, Bernstein BE, Liu DR, Joung JK. In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites. Nucleic Acids Research. 41: e181. PMID 23945932 DOI: 10.1093/Nar/Gkt716  0.747
2013 Pattanayak V, Lin S, Guilinger JP, Ma E, Doudna JA, Liu DR. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nature Biotechnology. 31: 839-43. PMID 23934178 DOI: 10.1038/Nbt.2673  0.808
2013 Dickinson BC, Leconte AM, Allen B, Esvelt KM, Liu DR. Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution Proceedings of the National Academy of Sciences of the United States of America. 110: 9007-9012. PMID 23674678 DOI: 10.1073/Pnas.1220670110  0.791
2013 Curtis EA, Liu DR. Discovery of widespread GTP-binding motifs in genomic DNA and RNA. Chemistry & Biology. 20: 521-32. PMID 23601641 DOI: 10.1016/J.Chembiol.2013.02.015  0.361
2013 Niu J, Hili R, Liu DR. Enzyme-free translation of DNA into sequence-defined synthetic polymers structurally unrelated to nucleic acids. Nature Chemistry. 5: 282-92. PMID 23511416 DOI: 10.1038/Nchem.1577  0.613
2013 Leconte AM, Dickinson BC, Yang DD, Chen IA, Allen B, Liu DR. A population-based experimental model for protein evolution: Effects of mutation rate and selection stringency on evolutionary outcomes Biochemistry. 52: 1490-1499. PMID 23360105 DOI: 10.1021/Bi3016185  0.808
2013 Hili R, Niu J, Liu DR. DNA ligase-mediated translation of DNA into densely functionalized nucleic acid polymers. Journal of the American Chemical Society. 135: 98-101. PMID 23256841 DOI: 10.1021/Ja311331M  0.611
2012 Dumelin CE, Chen Y, Leconte AM, Chen YG, Liu DR. Discovery and biological characterization of geranylated RNA in bacteria. Nature Chemical Biology. 8: 913-9. PMID 22983156 DOI: 10.1038/Nchembio.1070  0.765
2012 Thompson DB, Villaseñor R, Dorr BM, Zerial M, Liu DR. Cellular uptake mechanisms and endosomal trafficking of supercharged proteins. Chemistry & Biology. 19: 831-43. PMID 22840771 DOI: 10.1016/J.Chembiol.2012.06.014  0.328
2012 Georghiou G, Kleiner RE, Pulkoski-Gross M, Liu DR, Seeliger MA. Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles. Nature Chemical Biology. 8: 366-74. PMID 22344177 DOI: 10.1038/Nchembio.792  0.703
2012 Thompson DB, Cronican JJ, Liu DR. Engineering and identifying supercharged proteins for macromolecule delivery into mammalian cells. Methods in Enzymology. 503: 293-319. PMID 22230574 DOI: 10.1016/B978-0-12-396962-0.00012-4  0.79
2011 Fan JA, He Y, Bao K, Wu C, Bao J, Schade NB, Manoharan VN, Shvets G, Nordlander P, Liu DR, Capasso F. DNA-enabled self-assembly of plasmonic nanoclusters Nano Letters. 11: 4859-4864. PMID 22007607 DOI: 10.1021/Nl203194M  0.322
2011 Pattanayak V, Ramirez CL, Joung JK, Liu DR. Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection. Nature Methods. 8: 765-70. PMID 21822273 DOI: 10.1038/Nmeth.1670  0.753
2011 Cronican JJ, Beier KT, Davis TN, Tseng JC, Li W, Thompson DB, Shih AF, May EM, Cepko CL, Kung AL, Zhou Q, Liu DR. A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chemistry & Biology. 18: 833-8. PMID 21802004 DOI: 10.1016/J.Chembiol.2011.07.003  0.786
2011 Chen I, Dorr BM, Liu DR. A general strategy for the evolution of bond-forming enzymes using yeast display. Proceedings of the National Academy of Sciences of the United States of America. 108: 11399-404. PMID 21697512 DOI: 10.1073/Pnas.1101046108  0.343
2011 Yi F, Pereira L, Hoffman JA, Shy BR, Yuen CM, Liu DR, Merrill BJ. Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nature Cell Biology. 13: 762-70. PMID 21685894 DOI: 10.1038/Ncb2283  0.584
2011 Kleiner RE, Dumelin CE, Liu DR. Small-molecule discovery from DNA-encoded chemical libraries. Chemical Society Reviews. 40: 5707-17. PMID 21674077 DOI: 10.1039/C1Cs15076F  0.746
2011 He Y, Liu DR. A sequential strand-displacement strategy enables efficient six-step DNA-templated synthesis. Journal of the American Chemical Society. 133: 9972-5. PMID 21657248 DOI: 10.1021/Ja201361T  0.413
2011 Lin A, Jimenez J, Derr J, Vera P, Manapat ML, Esvelt KM, Villanueva L, Liu DR, Chen IA. Inhibition of bacterial conjugation by phage M13 and its protein g3p: quantitative analysis and model. Plos One. 6: e19991. PMID 21637841 DOI: 10.1371/Journal.Pone.0019991  0.648
2011 Peck SH, Chen I, Liu DR. Directed evolution of a small-molecule-triggered intein with improved splicing properties in mammalian cells. Chemistry & Biology. 18: 619-30. PMID 21609843 DOI: 10.1016/J.Chembiol.2011.02.014  0.732
2011 Esvelt KM, Carlson JC, Liu DR. A system for the continuous directed evolution of biomolecules. Nature. 472: 499-503. PMID 21478873 DOI: 10.1038/Nature09929  0.776
2011 Karanicolas J, Corn JE, Chen I, Joachimiak LA, Dym O, Peck SH, Albeck S, Unger T, Hu W, Liu G, Delbecq S, Montelione GT, Spiegel CP, Liu DR, Baker D. A de novo protein binding pair by computational design and directed evolution. Molecular Cell. 42: 250-60. PMID 21458342 DOI: 10.1016/J.Molcel.2011.03.010  0.716
2011 Chen Y, Kamlet AS, Steinman JB, Liu DR. A biomolecule-compatible visible-light-induced azide reduction from a DNA-encoded reaction-discovery system. Nature Chemistry. 3: 146-53. PMID 21258388 DOI: 10.1038/Nchem.932  0.783
2010 McGregor LM, Gorin DJ, Dumelin CE, Liu DR. Interaction-dependent PCR: Identification of ligand-target pairs from libraries of ligands and libraries of targets in a single solution-phase experiment Journal of the American Chemical Society. 132: 15522-15524. PMID 20949943 DOI: 10.1021/Ja107677Q  0.786
2010 He Y, Liu DR. Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker. Nature Nanotechnology. 5: 778-82. PMID 20935654 DOI: 10.1038/Nnano.2010.190  0.399
2010 Kleiner RE, Dumelin CE, Tiu GC, Sakurai K, Liu DR. In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors. Journal of the American Chemical Society. 132: 11779-91. PMID 20681606 DOI: 10.1021/Ja104903X  0.74
2010 Ruff KM, Snyder TM, Liu DR. Enhanced functional potential of nucleic acid aptamer libraries patterned to increase secondary structure. Journal of the American Chemical Society. 132: 9453-64. PMID 20565094 DOI: 10.1021/Ja103023M  0.803
2010 Cronican JJ, Thompson DB, Beier KT, McNaughton BR, Cepko CL, Liu DR. Potent delivery of functional proteins into Mammalian cells in vitro and in vivo using a supercharged protein. Acs Chemical Biology. 5: 747-52. PMID 20545362 DOI: 10.1021/Cb1001153  0.784
2010 Huang Y, Pastor WA, Shen Y, Tahiliani M, Liu DR, Rao A. The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. Plos One. 5: e8888. PMID 20126651 DOI: 10.1371/Journal.Pone.0008888  0.375
2010 Brudno Y, Birnbaum ME, Kleiner RE, Liu DR. An in vitro translation, selection and amplification system for peptide nucleic acids. Nature Chemical Biology. 6: 148-55. PMID 20081830 DOI: 10.1038/Nchembio.280  0.8
2010 Liu DR, Schultz PG. ChemInform Abstract: Generating New Molecular Function: A Lesson from Nature Cheminform. 30: no-no. DOI: 10.1002/chin.199918258  0.345
2009 Dempsey GT, Bates M, Kowtoniuk WE, Liu DR, Tsien RY, Zhuang X. Photoswitching mechanism of cyanine dyes. Journal of the American Chemical Society. 131: 18192-3. PMID 19961226 DOI: 10.1021/Ja904588G  0.758
2009 Chen YG, Kowtoniuk WE, Agarwal I, Shen Y, Liu DR. LC/MS analysis of cellular RNA reveals NAD-linked RNA. Nature Chemical Biology. 5: 879-81. PMID 19820715 DOI: 10.1038/Nchembio.235  0.785
2009 Heemstra JM, Liu DR. Templated synthesis of peptide nucleic acids via sequence-selective base-filling reactions. Journal of the American Chemical Society. 131: 11347-9. PMID 19722647 DOI: 10.1021/Ja904712T  0.369
2009 Gorin DJ, Kamlet AS, Liu DR. Reactivity-dependent PCR: Direct, solution-phase in vitro selection for bond formation Journal of the American Chemical Society. 131: 9189-9191. PMID 19522494 DOI: 10.1021/Ja903084A  0.804
2009 Kowtoniuk WE, Shen Y, Heemstra JM, Agarwal I, Liu DR. A chemical screen for biological small molecule-RNA conjugates reveals CoA-linked RNA. Proceedings of the National Academy of Sciences of the United States of America. 106: 7768-73. PMID 19416889 DOI: 10.1073/Pnas.0900528106  0.787
2009 Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (New York, N.Y.). 324: 930-5. PMID 19372391 DOI: 10.1126/Science.1170116  0.748
2009 Brudno Y, Liu DR. Recent progress toward the templated synthesis and directed evolution of sequence-defined synthetic polymers. Chemistry & Biology. 16: 265-76. PMID 19318208 DOI: 10.1016/J.Chembiol.2009.02.004  0.715
2009 McNaughton BR, Cronican JJ, Thompson DB, Liu DR. Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins. Proceedings of the National Academy of Sciences of the United States of America. 106: 6111-6. PMID 19307578 DOI: 10.1073/Pnas.0807883106  0.801
2008 Tse BN, Snyder TM, Shen Y, Liu DR. Translation of DNA into a library of 13,000 synthetic small-molecule macrocycles suitable for in vitro selection. Journal of the American Chemical Society. 130: 15611-26. PMID 18956864 DOI: 10.1021/Ja805649F  0.817
2008 Kleiner RE, Brudno Y, Birnbaum ME, Liu DR. DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes. Journal of the American Chemical Society. 130: 4646-59. PMID 18341334 DOI: 10.1021/Ja0753997  0.797
2008 Snyder TM, Tse BN, Liu DR. Effects of template sequence and secondary structure on DNA-templated reactivity. Journal of the American Chemical Society. 130: 1392-401. PMID 18179216 DOI: 10.1021/Ja076780U  0.813
2007 Yuen CM, Liu DR. Dissecting protein structure and function using directed evolution. Nature Methods. 4: 995-7. PMID 18049466 DOI: 10.1038/Nmeth1207-995  0.644
2007 Rozenman MM, Kanan MW, Liu DR. Development and initial application of a hybridization-independent, DNA-encoded reaction discovery system compatible with organic solvents. Journal of the American Chemical Society. 129: 14933-8. PMID 17994738 DOI: 10.1021/Ja074155J  0.807
2007 Liu JM, Liu DR. Discovery of a mRNA mitochondrial localization element in Saccharomyces cerevisiae by nonhomologous random recombination and in vivo selection. Nucleic Acids Research. 35: 6750-61. PMID 17916575 DOI: 10.1093/Nar/Gkm777  0.538
2007 Doyon JB, Liu DR. Identification of eukaryotic promoter regulatory elements using nonhomologous random recombination. Nucleic Acids Research. 35: 5851-60. PMID 17720707 DOI: 10.1093/Nar/Gkm634  0.756
2007 Lawrence MS, Phillips KJ, Liu DR. Supercharging proteins can impart unusual resilience. Journal of the American Chemical Society. 129: 10110-2. PMID 17665911 DOI: 10.1021/Ja071641Y  0.729
2007 Fischbach MA, Lai JR, Roche ED, Walsh CT, Liu DR. Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes. Proceedings of the National Academy of Sciences of the United States of America. 104: 11951-6. PMID 17620609 DOI: 10.1073/Pnas.0705348104  0.462
2007 Rozenman MM, McNaughton BR, Liu DR. Solving chemical problems through the application of evolutionary principles. Current Opinion in Chemical Biology. 11: 259-68. PMID 17548235 DOI: 10.1016/J.Cbpa.2007.05.016  0.788
2007 Momiyama N, Kanan MW, Liu DR. Synthesis of acyclic alpha,beta-unsaturated ketones via Pd(II)-catalyzed intermolecular reaction of alkynamides and alkenes. Journal of the American Chemical Society. 129: 2230-1. PMID 17279758 DOI: 10.1021/Ja068886F  0.605
2007 Kehayova PD, Liu DR. In vivo evolution of an RNA-based transcriptional silencing domain in S. cerevisiae. Chemistry & Biology. 14: 65-74. PMID 17254953 DOI: 10.1016/J.Chembiol.2006.11.008  0.789
2007 Momiyama N, Kanan MW, Liu DR. Synthesis of Acyclic α,β-Unsaturated Ketones via Pd(II)-Catalyzed Intermolecular Reaction of Alkynamides and Alkenes. Cheminform. 38. DOI: 10.1002/chin.200725070  0.565
2007 Liu DR, Schultz PG. Generating New Molecular Function: A Lesson from Nature Essays in Contemporary Chemistry: From Molecular Structure Towards Biology. 341-379. DOI: 10.1002/(Sici)1521-3773(19990115)38:1/2<36::Aid-Anie36>3.0.Co;2-I  0.477
2006 Luo M, Lin H, Fischbach MA, Liu DR, Walsh CT, Groves JT. Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition. Acs Chemical Biology. 1: 29-32. PMID 17163637 DOI: 10.1021/Cb0500034  0.384
2006 Fischbach MA, Lin H, Zhou L, Yu Y, Abergel RJ, Liu DR, Raymond KN, Wanner BL, Strong RK, Walsh CT, Aderem A, Smith KD. The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proceedings of the National Academy of Sciences of the United States of America. 103: 16502-7. PMID 17060628 DOI: 10.1073/Pnas.0604636103  0.403
2006 Phillips KJ, Rosenbaum DM, Liu DR. Binding and stability determinants of the PPARgamma nuclear receptor-coactivator interface as revealed by shotgun alanine scanning and in vivo selection. Journal of the American Chemical Society. 128: 11298-306. PMID 16925449 DOI: 10.1021/Ja0635985  0.742
2006 Lai JR, Fischbach MA, Liu DR, Walsh CT. Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection. Journal of the American Chemical Society. 128: 11002-3. PMID 16925399 DOI: 10.1021/Ja063238H  0.473
2006 Lin H, Fischbach MA, Gatto GJ, Liu DR, Walsh CT. Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase. Journal of the American Chemical Society. 128: 9324-5. PMID 16848455 DOI: 10.1021/Ja063236X  0.42
2006 Yuen CM, Rodda SJ, Vokes SA, McMahon AP, Liu DR. Control of transcription factor activity and osteoblast differentiation in mammalian cells using an evolved small-molecule-dependent intein. Journal of the American Chemical Society. 128: 8939-46. PMID 16819890 DOI: 10.1021/Ja062980E  0.645
2006 Lai JR, Fischbach MA, Liu DR, Walsh CT. A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection. Proceedings of the National Academy of Sciences of the United States of America. 103: 5314-9. PMID 16567620 DOI: 10.1073/Pnas.0601038103  0.472
2006 Fischbach MA, Lin H, Liu DR, Walsh CT. How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nature Chemical Biology. 2: 132-8. PMID 16485005 DOI: 10.1038/Nchembio771  0.412
2006 Doyon JB, Pattanayak V, Meyer CB, Liu DR. Directed evolution and substrate specificity profile of homing endonuclease I-SceI. Journal of the American Chemical Society. 128: 2477-84. PMID 16478204 DOI: 10.1021/Ja057519L  0.814
2006 Rozenman MM, Liu DR. DNA-templated synthesis in organic solvents. Chembiochem : a European Journal of Chemical Biology. 7: 253-6. PMID 16381048 DOI: 10.1002/Cbic.200500413  0.782
2005 Calderone CT, Liu DR. Small-molecule diversification from iterated branching reaction pathways enabled by DNA-templated synthesis. Angewandte Chemie (International Ed. in English). 44: 7383-6. PMID 16240310 DOI: 10.1002/Anie.200502899  0.785
2005 Snyder TM, Liu DR. Ordered multistep synthesis in a single solution directed by DNA templates. Angewandte Chemie (International Ed. in English). 44: 7379-82. PMID 16217825 DOI: 10.1002/Anie.200502879  0.655
2005 Lin H, Fischbach MA, Liu DR, Walsh CT. In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes. Journal of the American Chemical Society. 127: 11075-84. PMID 16076215 DOI: 10.1021/Ja0522027  0.388
2005 Liu JM, Bittker JA, Lonshteyn M, Liu DR. Functional dissection of sRNA translational regulators by nonhomologous random recombination and in vivo selection. Chemistry & Biology. 12: 757-67. PMID 16039523 DOI: 10.1016/J.Chembiol.2005.05.014  0.773
2005 Buskirk AR, Liu DR. Creating small-molecule-dependent switches to modulate biological functions. Chemistry & Biology. 12: 151-61. PMID 15734643 DOI: 10.1016/J.Chembiol.2004.11.012  0.701
2005 Sakurai K, Snyder TM, Liu DR. DNA-templated functional group transformations enable sequence-programmed synthesis using small-molecule reagents. Journal of the American Chemical Society. 127: 1660-1. PMID 15700999 DOI: 10.1021/Ja0432315  0.691
2005 Fischbach MA, Lin H, Liu DR, Walsh CT. In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 102: 571-6. PMID 15598734 DOI: 10.1073/Pnas.0408463102  0.388
2004 Calderone CT, Liu DR. Nucleic-acid-templated synthesis as a model system for ancient translation. Current Opinion in Chemical Biology. 8: 645-53. PMID 15556410 DOI: 10.1016/J.Cbpa.2004.09.003  0.772
2004 Kanan MW, Rozenman MM, Sakurai K, Snyder TM, Liu DR. Reaction discovery enabled by DNA-templated synthesis and in vitro selection. Nature. 431: 545-9. PMID 15457254 DOI: 10.1038/Nature02920  0.802
2004 Li X, Liu DR. DNA-templated organic synthesis: nature's strategy for controlling chemical reactivity applied to synthetic molecules. Angewandte Chemie (International Ed. in English). 43: 4848-70. PMID 15372570 DOI: 10.1002/Anie.200400656  0.415
2004 Buskirk AR, Landrigan A, Liu DR. Engineering a ligand-dependent RNA transcriptional activator. Chemistry & Biology. 11: 1157-63. PMID 15324817 DOI: 10.1016/J.Chembiol.2004.05.017  0.711
2004 Gartner ZJ, Tse BN, Grubina R, Doyon JB, Snyder TM, Liu DR. DNA-templated organic synthesis and selection of a library of macrocycles Science. 305: 1601-1605. PMID 15319493 DOI: 10.1126/Science.1102629  0.815
2004 Liu DR. Translating DNA into synthetic molecules. Plos Biology. 2: E223. PMID 15252462 DOI: 10.1371/Journal.Pbio.0020223  0.358
2004 Buskirk AR, Ong YC, Gartner ZJ, Liu DR. Directed evolution of ligand dependence: Small-molecule-activated protein splicing Proceedings of the National Academy of Sciences of the United States of America. 101: 10505-10510. PMID 15247421 DOI: 10.1073/Pnas.0402762101  0.796
2004 Bittker JA, Le BV, Liu JM, Liu DR. Directed evolution of protein enzymes using nonhomologous random recombination. Proceedings of the National Academy of Sciences of the United States of America. 101: 7011-6. PMID 15118093 DOI: 10.1073/Pnas.0402202101  0.776
2004 Li X, Gartner ZJ, Tse BN, Liu DR. Translation of DNA into Synthetic N-Acyloxazolidines Journal of the American Chemical Society. 126: 5090-5092. PMID 15099091 DOI: 10.1021/Ja049666+  0.815
2003 Rosenbaum DM, Liu DR. Efficient and sequence-specific DNA-templated polymerization of peptide nucleic acid aldehydes. Journal of the American Chemical Society. 125: 13924-5. PMID 14611205 DOI: 10.1021/Ja038058B  0.634
2003 Doyon JB, Snyder TM, Liu DR. Highly sensitive in vitro selections for DNA-linked synthetic small molecules with protein binding affinity and specificity. Journal of the American Chemical Society. 125: 12372-3. PMID 14531656 DOI: 10.1021/Ja036065U  0.815
2003 Li X, Liu DR. Stereoselectivity in DNA-templated organic synthesis and its origins. Journal of the American Chemical Society. 125: 10188-9. PMID 12926938 DOI: 10.1021/Ja035379E  0.389
2003 Buskirk AR, Kehayova PD, Landrigan A, Liu DR. In vivo evolution of an RNA-based transcriptional activator. Chemistry & Biology. 10: 533-40. PMID 12837386 DOI: 10.1016/S1074-5521(03)00109-1  0.793
2003 Gartner ZJ, Grubina R, Calderone CT, Liu DR. Two enabling architectures for DNA-templated organic synthesis Angewandte Chemie - International Edition. 42: 1370-1375. PMID 12671971 DOI: 10.1002/Anie.200390351  0.796
2002 Gartner ZJ, Kanan MW, Liu DR. Expanding the reaction scope of DNA-templated synthesis. Angewandte Chemie (International Ed. in English). 41: 1796-800. PMID 19750721 DOI: 10.1002/1521-3773(20020517)41:10<1796::Aid-Anie1796>3.0.Co;2-Z  0.794
2002 Calderone CT, Puckett JW, Gartner ZJ, Liu DR. Directing otherwise incompatible reactions in a single solution by using DNA-templated organic synthesis Angewandte Chemie - International Edition. 41: 4104-4108. PMID 12412096 DOI: 10.1002/1521-3773(20021104)41:21<4104::Aid-Anie4104>3.0.Co;2-O  0.793
2002 Bittker JA, Le BV, Liu DR. Nucleic acid evolution and minimization by nonhomologous random recombination. Nature Biotechnology. 20: 1024-9. PMID 12219078 DOI: 10.1038/Nbt736  0.729
2002 Gartner ZJ, Kanan MW, Liu DR. Multistep small-molecule synthesis programmed by DNA templates. Journal of the American Chemical Society. 124: 10304-6. PMID 12197733 DOI: 10.1021/Ja027307D  0.795
2002 Bittker JA, Phillips KJ, Liu DR. Recent advances in the in vitro evolution of nucleic acids. Current Opinion in Chemical Biology. 6: 367-74. PMID 12023118 DOI: 10.1016/S1367-5931(02)00321-6  0.804
2002 Gruen M, Chang K, Serbanescu I, Liu DR. An in vivo selection system for homing endonuclease activity. Nucleic Acids Research. 30: e29. PMID 11917035 DOI: 10.1093/Nar/30.7.E29  0.421
2001 Gartner ZJ, Liu DR. The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules Journal of the American Chemical Society. 123: 6961-6963. PMID 11448217 DOI: 10.1021/Ja015873N  0.666
2000 Wendt KU, Schulz GE, Corey EJ, Liu DR. Enzyme Mechanisms for Polycyclic Triterpene Formation. Angewandte Chemie (International Ed. in English). 39: 2812-2833. PMID 11027983 DOI: 10.1002/1521-3773(20000818)39:16<2812::Aid-Anie2812>3.0.Co;2-#  0.432
2000 Wang L, Magliery TJ, Liu DR, Schultz PG. A new functional suppressor tRNA/aminoacyl-tRNA synthetase pair for the in vivo incorporation of unnatural amino acids into proteins [16] Journal of the American Chemical Society. 122: 5010-5011. DOI: 10.1021/Ja000595Y  0.788
2000 Wendt K, Schulz G, Corey E, Liu D. Mechanismen der enzymatischen Bildung polycyclischer Triterpene Angewandte Chemie. 112: 2930-2952. DOI: 10.1002/1521-3757(20000818)112:16<2930::Aid-Ange2930>3.0.Co;2-S  0.339
1999 Liu DR, Schultz PG. Progress toward the evolution of an organism with an expanded genetic code. Proceedings of the National Academy of Sciences of the United States of America. 96: 4780-5. PMID 10220370 DOI: 10.1073/Pnas.96.9.4780  0.482
1999 Liu DR, Schultz PG. Das Hervorbringen neuer molekularer Funktionen: ein Lehrstück der Natur Angewandte Chemie. 111: 36-56. DOI: 10.1002/(Sici)1521-3757(19990115)111:1/2<36::Aid-Ange36>3.0.Co;2-J  0.383
1997 Liu DR, Magliery TJ, Schultz PG. Characterization of an 'orthogonal' suppressor tRNA derived from E. coli tRNA2(Gln). Chemistry & Biology. 4: 685-91. PMID 9331409 DOI: 10.1016/S1074-5521(97)90224-6  0.792
1997 Liu DR, Magliery TJ, Pastrnak M, Schultz PG. Engineering a tRNA and aminoacyl-tRNA synthetase for the site-specific incorporation of unnatural amino acids into proteins in vivo. Proceedings of the National Academy of Sciences of the United States of America. 94: 10092-7. PMID 9294168 DOI: 10.1073/Pnas.94.19.10092  0.798
1996 Cload ST, Liu DR, Froland WA, Schultz PG. Development of improved tRNAs for in vitro biosynthesis of proteins containing unnatural amino acids. Chemistry & Biology. 3: 1033-8. PMID 9000011 DOI: 10.1016/S1074-5521(96)90169-6  0.789
1996 Cload ST, Liu DR, Pastor RM, Schultz PG. Mutagenesis Study of Active Site Residues in Chorismate Mutase fromBacillus subtilis Journal of the American Chemical Society. 118: 1787-1788. DOI: 10.1021/Ja953152G  0.77
1996 Liu DR, Cload ST, Pastor RM, Schultz PG. Analysis of Active Site Residues inEscherichia coliChorismate Mutase by Site-Directed Mutagenesis Journal of the American Chemical Society. 118: 1789-1790. DOI: 10.1021/Ja953151O  0.767
1995 Baker CH, Matsuda SP, Liu DR, Corey EJ. Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library. Biochemical and Biophysical Research Communications. 213: 154-60. PMID 7639730 DOI: 10.1006/Bbrc.1995.2110  0.433
1994 Corey E, Lee J, Liu DR. First demonstration of a carbocation-olefin cyclization route to the lanosterol series Tetrahedron Letters. 35: 9149-9152. DOI: 10.1016/0040-4039(94)88450-1  0.404
1992 Corey EJ, Virgil SC, Liu DR, Sarshar S. The methyl group at C(10) of 2,3-oxidosqualene is crucial to the correct folding of this substrate in the cyclization-rearrangement step of sterol biosynthesis Journal of the American Chemical Society. 114: 1524-1525. DOI: 10.1021/Ja00030A083  0.384
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