Peter Walter, Ph.D. - Publications

Affiliations: 
Biochemistry & Biophysics University of California, San Francisco, San Francisco, CA 
Area:
Secretion, UPR
Website:
http://profiles.ucsf.edu/peter.walter

312 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Le Thomas A, Ferri E, Marsters S, Harnoss JM, Lawrence DA, Zuazo-Gaztelu I, Modrusan Z, Chan S, Solon M, Chalouni C, Li W, Koeppen H, Rudolph J, Wang W, Wu TD, ... Walter P, et al. Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α. Nature Communications. 12: 7310. PMID 34911951 DOI: 10.1038/s41467-021-27597-7  0.728
2021 Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter P. Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nature Communications. 12: 7103. PMID 34876554 DOI: 10.1038/s41467-021-26164-4  0.652
2021 Li W, Crotty K, Garrido Ruiz D, Voorhies M, Rivera C, Sil A, Mullins RD, Jacobson MP, Peschek J, Walter P. Protomer alignment modulates specificity of RNA substrate recognition by Ire1. Elife. 10. PMID 33904404 DOI: 10.7554/eLife.67425  0.709
2021 Schoof M, Boone M, Wang L, Lawrence R, Frost A, Walter P. eIF2B conformation and assembly state regulates the integrated stress response. Elife. 10. PMID 33688831 DOI: 10.7554/eLife.65703  0.633
2020 Ramundo S, Asakura Y, Salomé PA, Strenkert D, Boone M, Mackinder LCM, Takafuji K, Dinc E, Rahire M, Crèvecoeur M, Magneschi L, Schaad O, Hippler M, Jonikas MC, Merchant S, ... Walter P, et al. Coexpressed subunits of dual genetic origin define a conserved supercomplex mediating essential protein import into chloroplasts. Proceedings of the National Academy of Sciences of the United States of America. PMID 33273113 DOI: 10.1073/pnas.2014294117  0.75
2020 Krukowski K, Nolan A, Frias ES, Boone M, Ureta G, Grue K, Paladini MS, Elizarraras E, Delgado L, Bernales S, Walter P, Rosi S. Small molecule cognitive enhancer reverses age-related memory decline in mice. Elife. 9. PMID 33258451 DOI: 10.7554/eLife.62048  0.672
2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, ... Walter P, et al. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science (New York, N.Y.). PMID 33154106 DOI: 10.1126/science.abe3255  0.781
2020 Wang L, Walter P. Msp1/ATAD1 in Protein Quality Control and Regulation of Synaptic Activities. Annual Review of Cell and Developmental Biology. PMID 32886535 DOI: 10.1146/Annurev-Cellbio-031220-015840  0.431
2020 Rabouw HH, Visser LJ, Passchier TC, Langereis MA, Liu F, Giansanti P, van Vliet ALW, Dekker JG, van der Grein SG, Saucedo JG, Anand AA, Trellet ME, Bonvin AMJJ, Walter P, Heck AJR, et al. Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association. Nature Microbiology. PMID 32690955 DOI: 10.1038/S41564-020-0759-0  0.364
2020 Dufey E, Bravo-San Pedro JM, Eggers C, González-Quiroz M, Urra H, Sagredo AI, Sepulveda D, Pihán P, Carreras-Sureda A, Hazari Y, Sagredo EA, Gutierrez D, Valls C, Papaioannou A, Acosta-Alvear D, ... Walter P, et al. Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response. Nature Communications. 11: 2401. PMID 32409639 DOI: 10.1038/S41467-020-15694-Y  0.348
2020 Costa-Mattioli M, Walter P. The integrated stress response: From mechanism to disease. Science (New York, N.Y.). 368. PMID 32327570 DOI: 10.1126/Science.Aat5314  0.368
2020 Carter SD, Hampton CM, Langlois R, Melero R, Farino ZJ, Calderon MJ, Li W, Wallace CT, Tran NH, Grassucci RA, Siegmund SE, Pemberton J, Morgenstern TJ, Eisenman L, Aguilar JI, ... Walter P, et al. Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells. Science Advances. 6: eaay9572. PMID 32270040 DOI: 10.1126/Sciadv.Aay9572  0.341
2020 Harnoss JM, Le Thomas A, Reichelt M, Guttman O, Wu TD, Marsters SA, Shemorry A, Lawrence DA, Kan D, Segal E, Merchant M, Totpal K, Crocker LM, Mesh K, Dohse M, ... Walter P, et al. IRE1α disruption in triple-negative breast cancer cooperates with anti-angiogenic therapy by reversing ER stress adaptation and remodeling the tumor microenvironment. Cancer Research. PMID 32265225 DOI: 10.1158/0008-5472.Can-19-3108  0.352
2020 Wang L, Myasnikov A, Pan X, Walter P. Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. Elife. 9. PMID 31999255 DOI: 10.7554/Elife.54031  0.425
2020 Lam M, Marsters SA, Ashkenazi A, Walter P. Misfolded proteins bind and activate death receptor 5 to induce apoptosis during unresolved endoplasmic reticulum stress. Elife. 9. PMID 31904339 DOI: 10.7554/Elife.52291  0.439
2020 Li W, Crotty K, Ruiz DG, Peschek J, Walter P. Regulating ER protein homeostasis by differentially processing mRNAs The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00507  0.745
2019 Krukowski K, Nolan A, Frias E, Grue K, Becker M, Ureta G, Delgado L, Bernales S, Sohal VS, Walter P, Rosi S. Integrated stress response inhibitor reverses sex-dependent behavioral and cell-specific deficits after mild repetitive head trauma. Journal of Neurotrauma. PMID 31884883 DOI: 10.1089/Neu.2019.6827  0.691
2019 Belyy V, Tran NH, Walter P. Quantitative microscopy reveals dynamics and fate of clustered IRE1α. Proceedings of the National Academy of Sciences of the United States of America. PMID 31871156 DOI: 10.1073/Pnas.1915311117  0.307
2019 Zhu PJ, Khatiwada S, Cui Y, Reineke LC, Dooling SW, Kim JJ, Li W, Walter P, Costa-Mattioli M. Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. Science (New York, N.Y.). 366: 843-849. PMID 31727829 DOI: 10.1126/Science.Aaw5185  0.345
2019 Perlaza K, Toutkoushian H, Boone M, Lam M, Iwai M, Jonikas MC, Walter P, Ramundo S. The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response. Elife. 8. PMID 31612858 DOI: 10.7554/Elife.49577  0.752
2019 Anand AA, Walter P. Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response. The Febs Journal. PMID 31550413 DOI: 10.1111/Febs.15073  0.351
2019 Göke A, Schrott S, Mizrak A, Belyy V, Osman C, Walter P. Mrx6 regulates mitochondrial DNA copy number in by engaging the evolutionarily conserved Lon protease Pim1. Molecular Biology of the Cell. mbcE19080470. PMID 31532710 DOI: 10.1091/Mbc.E19-08-0470  0.31
2019 Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, ... Walter P, et al. Disruption of IRE1α through its kinase domain attenuates multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America. PMID 31371506 DOI: 10.1073/Pnas.1906999116  0.338
2019 Peschek J, Walter P. tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. Elife. 8. PMID 31237564 DOI: 10.7554/eLife.44199  0.378
2019 Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. Elife. 8. PMID 31149896 DOI: 10.7554/Elife.46595  0.738
2019 Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A. eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science (New York, N.Y.). 364: 491-495. PMID 31048491 DOI: 10.1126/Science.Aaw2922  0.676
2019 Rabouw HH, Langereis MA, Anand AA, Visser LJ, de Groot RJ, Walter P, van Kuppeveld FJM. Small molecule ISRIB suppresses the integrated stress response within a defined window of activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30674674 DOI: 10.1073/Pnas.1815767116  0.318
2019 Karagöz GE, Acosta-Alvear D, Walter P. The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum. Cold Spring Harbor Perspectives in Biology. PMID 30670466 DOI: 10.1101/Cshperspect.A033886  0.47
2019 Lam M, Marsters SA, Ashkenazi A, Walter P. Author response: Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress Elife. DOI: 10.7554/Elife.52291.Sa2  0.372
2019 Perlaza K, Toutkoushian H, Boone M, Lam M, Iwai M, Jonikas MC, Walter P, Ramundo S. Author response: The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response Elife. DOI: 10.7554/Elife.49577.040  0.732
2019 Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. Author response: Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether Elife. DOI: 10.7554/Elife.46595.022  0.691
2018 Acosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther TC, Walter P. The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1. Elife. 7. PMID 30582518 DOI: 10.7554/Elife.43036  0.727
2018 Lam M, Lawrence DA, Ashkenazi A, Walter P. Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress. Cell Death and Differentiation. PMID 29991746 DOI: 10.1038/S41418-018-0155-Y  0.309
2018 Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman JS, Walter P. Engineering ER-stress dependent non-conventional mRNA splicing. Elife. 7. PMID 29985129 DOI: 10.7554/Elife.35388  0.746
2018 Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, et al. Development of a stress response therapy targeting aggressive prostate cancer. Science Translational Medicine. 10. PMID 29720449 DOI: 10.1126/Scitranslmed.Aar2036  0.363
2018 Walter P, Anderson D. Günter Blobel (1936-2018). Science (New York, N.Y.). 360: 383. PMID 29700255 DOI: 10.1126/Science.Aat7913  0.37
2018 Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling. Cell Host & Microbe. 23: 571. PMID 29649448 DOI: 10.1016/j.chom.2018.03.005  0.671
2018 Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science (New York, N.Y.). 359. PMID 29599213 DOI: 10.1126/Science.Aaq0939  0.656
2018 Acosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther TC, Walter P. Author response: The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1 Elife. DOI: 10.7554/Elife.43036.025  0.695
2018 Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman JS, Walter P. Author response: Engineering ER-stress dependent non-conventional mRNA splicing Elife. DOI: 10.7554/Elife.35388.020  0.683
2017 Karagöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P. An unfolded protein-induced conformational switch activates mammalian IRE1. Elife. 6. PMID 28971800 DOI: 10.7554/Elife.30700  0.404
2017 Guydosh NR, Kimmig P, Walter P, Green R. Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe. Elife. 6. PMID 28945192 DOI: 10.7554/Elife.29216  0.421
2017 Cohen N, Breker M, Bakunts A, Pesek K, Chas A, Argemí J, Orsi A, Gal L, Chuartzman S, Wigelman Y, Jonas F, Walter P, Ernst R, Aragón T, van Anken E, et al. Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling. Journal of Cell Science. PMID 28794014 DOI: 10.1242/Jcs.201715  0.696
2017 Tufanli O, Telkoparan Akillilar P, Acosta-Alvear D, Kocaturk B, Onat UI, Hamid SM, Çimen I, Walter P, Weber C, Erbay E. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28137856 DOI: 10.1073/Pnas.1621188114  0.343
2017 Karagöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P. Author response: An unfolded protein-induced conformational switch activates mammalian IRE1 Elife. DOI: 10.7554/Elife.30700.034  0.357
2017 Guydosh NR, Kimmig P, Walter P, Green R. Author response: Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe Elife. DOI: 10.7554/Elife.29216.027  0.308
2016 Rao M, Okreglak V, Chio US, Cho H, Walter P, Shan SO. Multiple selection filters ensure accurate tail-anchored membrane protein targeting. Elife. 5. PMID 27925580 DOI: 10.7554/Elife.21301  0.822
2016 Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 27450084 DOI: 10.1073/Pnas.1603883113  0.388
2016 Gallagher CM, Walter P. Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress. Elife. 5. PMID 27435962 DOI: 10.7554/Elife.11880  0.42
2016 Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife. 5. PMID 27435961 DOI: 10.7554/Elife.15550  0.418
2016 Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. Elife. 5. PMID 27435960 DOI: 10.7554/Elife.11878  0.436
2016 Starck SR, Tsai JC, Chen K, Shodiya M, Wang L, Yahiro K, Martins-Green M, Shastri N, Walter P. Translation from the 5' untranslated region shapes the integrated stress response. Science (New York, N.Y.). 351: aad3867. PMID 26823435 DOI: 10.1126/Science.Aad3867  0.376
2016 Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. Chemmedchem. PMID 26789650 DOI: 10.1002/Cmdc.201500483  0.424
2016 Rao M, Okreglak V, Chio US, Cho H, Walter P, Shan S. Author response: Multiple selection filters ensure accurate tail-anchored membrane protein targeting Elife. DOI: 10.7554/Elife.21301.015  0.796
2016 Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, et al. Author response: Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation Elife. DOI: 10.7554/Elife.15550.026  0.381
2016 Gallagher CM, Walter P. Author response: Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress Elife. DOI: 10.7554/Elife.11880.029  0.335
2016 Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. Author response: Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch Elife. DOI: 10.7554/Elife.11878.029  0.339
2015 Elvekrog MM, Walter P. Dynamics of co-translational protein targeting. Current Opinion in Chemical Biology. 29: 79-86. PMID 26517565 DOI: 10.1016/J.Cbpa.2015.09.016  0.46
2015 Peschek J, Acosta-Alvear D, Mendez AS, Walter P. A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. Embo Reports. PMID 26483401 DOI: 10.15252/Embr.201540955  0.422
2015 Lang AB, John Peter AT, Walter P, Kornmann B. ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13. The Journal of Cell Biology. 210: 883-90. PMID 26370498 DOI: 10.1083/Jcb.201502105  0.703
2015 Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M. Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Elife. 4. PMID 26327694 DOI: 10.7554/Elife.08153  0.747
2015 Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife. 4. PMID 25986605 DOI: 10.7554/Elife.05434  0.764
2015 Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, ... Walter P, et al. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 4: e07314. PMID 25875391 DOI: 10.7554/Elife.07314  0.656
2015 Osman C, Noriega TR, Okreglak V, Fung JC, Walter P. Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion. Proceedings of the National Academy of Sciences of the United States of America. 112: E947-56. PMID 25730886 DOI: 10.1073/Pnas.1501737112  0.77
2015 Sidrauski C, McGeachy AM, Ingolia NT, Walter P. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. Elife. 4. PMID 25719440 DOI: 10.7554/Elife.05033  0.333
2015 Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the hsp70-bag3 protein-protein interaction as a potential therapeutic target in cancer. Molecular Cancer Therapeutics. 14: 642-8. PMID 25564440 DOI: 10.1158/1535-7163.Mct-14-0650  0.663
2015 Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M. Author response: Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits Elife. DOI: 10.7554/Elife.08153.019  0.753
2015 Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, ... Walter P, et al. Author response: Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response Elife. DOI: 10.7554/Elife.07314.017  0.616
2015 Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Author response: Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic Elife. DOI: 10.7554/Elife.05434.022  0.765
2015 Acosta-Alvear D, Kampmann M, Cho MY, Wild T, Choudhary C, Shuman MA, Weissman JS, Walter P. Abstract A43: Opposing roles of the 19S regulatory- and 20S core-proteasomal subunits in controlling sensitivity of multiple myeloma cells to proteasome inhibition. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-A43  0.656
2015 Acosta-Alvear D, Kampmann M, Cho MY, Aftab BT, Li X, Gestwicki JE, Shuman MA, Weissman JS, Walter P. Abstract A2-57: Identification of genetic vulnerabilities within the proteostasis network of multiple myeloma Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A2-57  0.64
2015 Kampmann M, Acosta-Alvear D, Gilbert LA, Horlbeck MA, Cho MY, Adamson B, Villalta J, Chen Y, Walter P, Weissman JS. Abstract A2-56: Cancer-specific synthetic lethality and network rewiring elucidated by genetic interaction maps and CRISPR-based gain- and loss-of-function screens Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A2-56  0.63
2015 Cho MY, Acosta-Alvear D, Kampmann M, Wild T, Choudhary CR, Weissman JS, Walter P. Abstract A2-12: Opposing roles of the 19S regulatory and 20S core proteasomal subunits in controlling sensitivity to proteasome inhibitors Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A2-12  0.645
2014 van Anken E, Pincus D, Coyle S, Aragón T, Osman C, Lari F, Gómez Puerta S, Korennykh AV, Walter P. Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1. Elife. 3: e05031. PMID 25549299 DOI: 10.7554/Elife.05031  0.74
2014 Noriega TR, Chen J, Walter P, Puglisi JD. Real-time observation of signal recognition particle binding to actively translating ribosomes. Elife. 3. PMID 25358118 DOI: 10.7554/Elife.04418  0.792
2014 Pincus D, Aranda-Díaz A, Zuleta IA, Walter P, El-Samad H. Delayed Ras/PKA signaling augments the unfolded protein response. Proceedings of the National Academy of Sciences of the United States of America. 111: 14800-5. PMID 25275008 DOI: 10.1073/Pnas.1409588111  0.77
2014 Schuck S, Gallagher CM, Walter P. ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery. Journal of Cell Science. 127: 4078-88. PMID 25052096 DOI: 10.1242/Jcs.154716  0.39
2014 Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A. Cell death. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science (New York, N.Y.). 345: 98-101. PMID 24994655 DOI: 10.1126/Science.1254312  0.395
2014 Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Krnjević K, Kaufman RJ, Walter P, Costa-Mattioli M. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α. Nature Neuroscience. 17: 1073-82. PMID 24974795 DOI: 10.1038/Nn.3754  0.3
2014 Okreglak V, Walter P. The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins. Proceedings of the National Academy of Sciences of the United States of America. 111: 8019-24. PMID 24821790 DOI: 10.1073/Pnas.1405755111  0.479
2014 Noriega TR, Tsai A, Elvekrog MM, Petrov A, Neher SB, Chen J, Bradshaw N, Puglisi JD, Walter P. Signal recognition particle-ribosome binding is sensitive to nascent chain length. The Journal of Biological Chemistry. 289: 19294-305. PMID 24808175 DOI: 10.1074/Jbc.M114.563239  0.8
2014 Noriega TR, Chen J, Walter P, Puglisi JD. Author response: Real-time observation of signal recognition particle binding to actively translating ribosomes Elife. DOI: 10.7554/Elife.04418.018  0.795
2013 Lim B, Miyazaki R, Neher S, Siegele DA, Ito K, Walter P, Akiyama Y, Yura T, Gross CA. Heat shock transcription factor σ32 co-opts the signal recognition particle to regulate protein homeostasis in E. coli. Plos Biology. 11: e1001735. PMID 24358019 DOI: 10.1371/Journal.Pbio.1001735  0.491
2013 Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, ... Walter P, et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2: e00498. PMID 23741617 DOI: 10.7554/Elife.00498  0.501
2013 Cho JA, Lee AH, Platzer B, Cross BC, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host & Microbe. 13: 558-69. PMID 23684307 DOI: 10.1016/J.Chom.2013.03.011  0.728
2013 Murley A, Lackner LL, Osman C, West M, Voeltz GK, Walter P, Nunnari J. ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. Elife. 2: e00422. PMID 23682313 DOI: 10.7554/Elife.00422  0.777
2013 Walter P. Two structure papers, a call from Frankfurt airport, and how to escape from reviewer delays: an interview with Peter Walter by Miranda Robertson. Bmc Biology. 11: 34. PMID 23587131 DOI: 10.1186/1741-7007-11-34  0.392
2013 Walter P, Metzger J, Thiel C, Helms V. Predicting where small molecules bind at protein-protein interfaces. Plos One. 8: e58583. PMID 23505538 DOI: 10.1371/Journal.Pone.0058583  0.399
2013 Gardner BM, Pincus D, Gotthardt K, Gallagher CM, Walter P. Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harbor Perspectives in Biology. 5: a013169. PMID 23388626 DOI: 10.1101/Cshperspect.A013169  0.785
2013 Murley A, Lackner LL, Osman C, West M, Voeltz GK, Walter P, Nunnari J. Author response: ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast Elife. DOI: 10.7554/Elife.00422.020  0.772
2013 Kampmann M, Acosta-Alvear D, Cho M, Chen Y, Li X, Gilbert L, Aftab BT, Gestwicki J, Walter P, Weissman JS. Abstract PR07: Systematic genetic interaction maps reveal rewiring of the stress response network and resulting vulnerabilities in leukemia and multiple myeloma cells Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-Pr07  0.641
2013 Acosta-Alvear D, Kampmann M, Bassik MC, Lee CP, Cho MY, Aftab BT, Li X, Gestwicki JE, Shuman MA, Weissman JS, Walter P. Abstract C01: Systematic blueprinting of genetic vulnerabilities using ultra-complex shRNA libraries identifies genes synergizing with proteasome inhibition or blockade of IRE1 in multiple myeloma cells Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-C01  0.661
2013 Kampmann M, Acosta-Alvear D, Bassik MC, Chen Y, Walter P, Weissman JS. Abstract PR06: Systematic genetic interaction maps reveal synthetic-lethal vulnerabilities in leukemia and multiple myeloma Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-Pr06  0.638
2013 Acosta-Alvear D, Kampmann M, Bassik MC, Lee CP, Shuman MA, Weissman JS, Walter P. Abstract A08: Systematic identification of genetic vulnerabilities synergizing with proteasome and IRE1 inhibition in multiple myeloma cells using ultra-complex shRNA libraries Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-A08  0.663
2012 Kimmig P, Diaz M, Zheng J, Williams CC, Lang A, Aragón T, Li H, Walter P. The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis. Elife. 1: e00048. PMID 23066505 DOI: 10.7554/Elife.00048  0.797
2012 Korennykh A, Walter P. Structural basis of the unfolded protein response. Annual Review of Cell and Developmental Biology. 28: 251-77. PMID 23057742 DOI: 10.1146/Annurev-Cellbio-101011-155826  0.44
2012 Fordyce PM, Pincus D, Kimmig P, Nelson CS, El-Samad H, Walter P, DeRisi JL. Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses. Proceedings of the National Academy of Sciences of the United States of America. 109: E3084-93. PMID 23054834 DOI: 10.1073/Pnas.1212457109  0.744
2012 Moreira KE, Schuck S, Schrul B, Fröhlich F, Moseley JB, Walther TC, Walter P. Seg1 controls eisosome assembly and shape. The Journal of Cell Biology. 198: 405-20. PMID 22869600 DOI: 10.1083/Jcb.201202097  0.809
2012 Pincus D, Walter P. A first line of defense against ER stress. The Journal of Cell Biology. 198: 277-9. PMID 22869593 DOI: 10.1083/Jcb.201207076  0.618
2012 Kimmig P, Diaz M, Zheng J, Williams CC, Lang A, Aragón T, Li H, Walter P. Author response: The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis Elife. DOI: 10.7554/Elife.00048.023  0.651
2012 Walter P, Ulucan O, Metzger J, Helms V. Bioinformatics of protein-protein interfaces and small molecule effectors Current Bioinformatics. 7: 159-172. DOI: 10.2174/157489312800604444  0.373
2012 Shuman M, Wells J, Shokat K, Bernales S, Walter P, Shultz L, Goodwin N. A quaternary equation for interdisciplinary medical research (IMR) Journal of Translational Medicine. 10. DOI: 10.1186/1479-5876-10-S2-A49  0.705
2011 Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science (New York, N.Y.). 334: 1081-6. PMID 22116877 DOI: 10.1126/Science.1209038  0.462
2011 Braunstein MJ, Scott SS, Scott CM, Behrman S, Walter P, Wipf P, Coplan JD, Chrico W, Joseph D, Brodsky JL, Batuman O. Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101. Journal of Oncology. 2011: 232037. PMID 21977030 DOI: 10.1155/2011/232037  0.783
2011 Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C. BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response. The Embo Journal. 30: 4465-78. PMID 21926971 DOI: 10.1038/Emboj.2011.318  0.377
2011 Gardner BM, Walter P. Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. Science (New York, N.Y.). 333: 1891-4. PMID 21852455 DOI: 10.1126/Science.1209126  0.712
2011 Kornmann B, Osman C, Walter P. The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections. Proceedings of the National Academy of Sciences of the United States of America. 108: 14151-6. PMID 21825164 DOI: 10.1073/Pnas.1111314108  0.71
2011 Nguyen TX, Chandrasekar S, Neher S, Walter P, Shan SO. Concerted complex assembly and GTPase activation in the chloroplast signal recognition particle. Biochemistry. 50: 7208-17. PMID 21780778 DOI: 10.1021/Bi200742A  0.742
2011 Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. Bmc Biology. 9: 48. PMID 21729334 DOI: 10.1186/1741-7007-9-48  0.81
2011 Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Structural and functional basis for RNA cleavage by Ire1. Bmc Biology. 9: 47. PMID 21729333 DOI: 10.1186/1741-7007-9-47  0.8
2011 Rubio C, Pincus D, Korennykh A, Schuck S, El-Samad H, Walter P. Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity. The Journal of Cell Biology. 193: 171-84. PMID 21444684 DOI: 10.1083/Jcb.201007077  0.83
2011 Singh NK, Goodman A, Walter P, Helms V, Hayat S. TMBHMM: a frequency profile based HMM for predicting the topology of transmembrane beta barrel proteins and the exposure status of transmembrane residues. Biochimica Et Biophysica Acta. 1814: 664-70. PMID 21426944 DOI: 10.1016/J.Bbapap.2011.03.004  0.342
2011 Behrman S, Acosta-Alvear D, Walter P. A CHOP-regulated microRNA controls rhodopsin expression. The Journal of Cell Biology. 192: 919-27. PMID 21402790 DOI: 10.1083/Jcb.201010055  0.79
2010 Li H, Korennykh AV, Behrman SL, Walter P. Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. Proceedings of the National Academy of Sciences of the United States of America. 107: 16113-8. PMID 20798350 DOI: 10.1073/Pnas.1010580107  0.831
2010 Pincus D, Chevalier MW, Aragón T, van Anken E, Vidal SE, El-Samad H, Walter P. BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response. Plos Biology. 8: e1000415. PMID 20625545 DOI: 10.1371/Journal.Pbio.1000415  0.827
2010 Battle A, Jonikas MC, Walter P, Weissman JS, Koller D. Automated identification of pathways from quantitative genetic interaction data. Molecular Systems Biology. 6: 379. PMID 20531408 DOI: 10.1038/Msb.2010.27  0.722
2010 Aguilar PS, Fröhlich F, Rehman M, Shales M, Ulitsky I, Olivera-Couto A, Braberg H, Shamir R, Walter P, Mann M, Ejsing CS, Krogan NJ, Walther TC. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Nature Structural & Molecular Biology. 17: 901-8. PMID 20526336 DOI: 10.1038/Nsmb.1829  0.617
2010 Engel A, Aguilar PS, Walter P. The yeast cell fusion protein Prm1p requires covalent dimerization to promote membrane fusion. Plos One. 5: e10593. PMID 20485669 DOI: 10.1371/Journal.Pone.0010593  0.632
2010 Kornmann B, Walter P. ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology. Journal of Cell Science. 123: 1389-93. PMID 20410371 DOI: 10.1242/Jcs.058636  0.707
2010 Aguilar PS, Heiman MG, Walther TC, Engel A, Schwudke D, Gushwa N, Kurzchalia T, Walter P. Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating. Proceedings of the National Academy of Sciences of the United States of America. 107: 4170-5. PMID 20150508 DOI: 10.1073/Pnas.0914094107  0.77
2010 Walter P. Walking along the serendipitous path of discovery. Molecular Biology of the Cell. 21: 15-7. PMID 20048259 DOI: 10.1091/Mbc.E09-08-0662  0.455
2009 Schuck S, Prinz WA, Thorn KS, Voss C, Walter P. Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. The Journal of Cell Biology. 187: 525-36. PMID 19948500 DOI: 10.1083/Jcb.200907074  0.417
2009 Doolittle MH, Neher SB, Ben-Zeev O, Ling-Liao J, Gallagher CM, Hosseini M, Yin F, Wong H, Walter P, Péterfy M. Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum. The Journal of Biological Chemistry. 284: 33623-33. PMID 19783858 DOI: 10.1074/Jbc.M109.049395  0.385
2009 Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS. Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. The Journal of Cell Biology. 186: 323-31. PMID 19651891 DOI: 10.1083/Jcb.200903014  0.591
2009 Fröhlich F, Moreira K, Aguilar PS, Hubner NC, Mann M, Walter P, Walther TC. A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling. The Journal of Cell Biology. 185: 1227-42. PMID 19564405 DOI: 10.1083/Jcb.200811081  0.81
2009 Kornmann B, Currie E, Collins SR, Schuldiner M, Nunnari J, Weissman JS, Walter P. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science (New York, N.Y.). 325: 477-81. PMID 19556461 DOI: 10.1126/Science.1175088  0.789
2009 Lisbona F, Rojas-Rivera D, Thielen P, Zamorano S, Todd D, Martinon F, Glavic A, Kress C, Lin JH, Walter P, Reed JC, Glimcher LH, Hetz C. BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Molecular Cell. 33: 679-91. PMID 19328063 DOI: 10.1016/J.Molcel.2009.02.017  0.439
2009 Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M. Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science (New York, N.Y.). 323: 1693-7. PMID 19325107 DOI: 10.1126/Science.1167983  0.768
2009 So AYL, De La Fuente E, Walter P, Shuman M, Bernales S. The unfolded protein response during prostate cancer development Cancer and Metastasis Reviews. 28: 219-223. PMID 19172382 DOI: 10.1007/S10555-008-9180-5  0.74
2009 Lin JH, Li H, Zhang Y, Ron D, Walter P. Divergent effects of PERK and IRE1 signaling on cell viability. Plos One. 4: e4170. PMID 19137072 DOI: 10.1371/Journal.Pone.0004170  0.556
2009 Bradshaw N, Neher SB, Booth DS, Walter P. Signal sequences activate the catalytic switch of SRP RNA. Science (New York, N.Y.). 323: 127-30. PMID 19119234 DOI: 10.1126/Science.1165971  0.807
2009 Aragón T, van Anken E, Pincus D, Serafimova IM, Korennykh AV, Rubio CA, Walter P. Messenger RNA targeting to endoplasmic reticulum stress signalling sites. Nature. 457: 736-40. PMID 19079237 DOI: 10.1038/Nature07641  0.821
2009 Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P. The unfolded protein response signals through high-order assembly of Ire1. Nature. 457: 687-93. PMID 19079236 DOI: 10.1038/Nature07661  0.795
2009 Moreira KE, Walther TC, Aguilar PS, Walter P. Pil1 controls eisosome biogenesis. Molecular Biology of the Cell. 20: 809-18. PMID 19037108 DOI: 10.1091/Mbc.E08-03-0313  0.796
2008 Neher SB, Bradshaw N, Floor SN, Gross JD, Walter P. SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction. Nature Structural & Molecular Biology. 15: 916-23. PMID 19172744 DOI: 10.1038/Nsmb.1467  0.787
2008 Egea PF, Tsuruta H, de Leon GP, Napetschnig J, Walter P, Stroud RM. Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane. Plos One. 3: e3619. PMID 18978942 DOI: 10.1371/Journal.Pone.0003619  0.782
2008 Egea PF, Napetschnig J, Walter P, Stroud RM. Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus. Plos One. 3: e3528. PMID 18953414 DOI: 10.1371/Journal.Pone.0003528  0.799
2008 Engel A, Walter P. Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines. The Journal of Cell Biology. 183: 181-6. PMID 18852300 DOI: 10.1083/Jcb.200805182  0.603
2008 Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature. 453: 657-61. PMID 18408709 DOI: 10.1038/Nature06928  0.608
2008 Lin JH, Walter P, Yen TS. Endoplasmic reticulum stress in disease pathogenesis. Annual Review of Pathology. 3: 399-425. PMID 18039139 DOI: 10.1146/Annurev.Pathmechdis.3.121806.151434  0.468
2008 Braunstein MJ, Scott CM, Behrman S, Walter P, Wipf P, Smith EL, Scott SS, Klueppelberg HU, Brodsky JL, Batuman O. Targeting Hsp70 in Multiple Myeloma Induces Synergistic Cytotoxicity with Inhibitors of the Proteasome and of Hsp90 Blood. 112: 5160-5160. DOI: 10.1182/Blood.V112.11.5160.5160  0.781
2007 Walther TC, Aguilar PS, Fröhlich F, Chu F, Moreira K, Burlingame AL, Walter P. Pkh-kinases control eisosome assembly and organization. The Embo Journal. 26: 4946-55. PMID 18034155 DOI: 10.1038/Sj.Emboj.7601933  0.807
2007 Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM, Walter P. IRE1 signaling affects cell fate during the unfolded protein response. Science (New York, N.Y.). 318: 944-9. PMID 17991856 DOI: 10.1126/Science.1146361  0.545
2007 Haass FA, Jonikas M, Walter P, Weissman JS, Jan YN, Jan LY, Schuldiner M. Identification of yeast proteins necessary for cell-surface function of a potassium channel. Proceedings of the National Academy of Sciences of the United States of America. 104: 18079-84. PMID 17989219 DOI: 10.1073/Pnas.0708765104  0.771
2007 Shan SO, Chandrasekar S, Walter P. Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation. The Journal of Cell Biology. 178: 611-20. PMID 17682051 DOI: 10.1083/Jcb.200702018  0.628
2007 Reyes CL, Rutenber E, Walter P, Stroud RM. X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates. Plos One. 2: e607. PMID 17622352 DOI: 10.1371/Journal.Pone.0000607  0.587
2007 Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nature Reviews. Molecular Cell Biology. 8: 519-29. PMID 17565364 DOI: 10.1038/Nrm2199  0.462
2007 Bradshaw N, Walter P. The signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting Molecular Biology of the Cell. 18: 2728-2734. PMID 17507650 DOI: 10.1091/Mbc.E07-02-0117  0.797
2007 Bernales S, Schuck S, Walter P. ER-phagy: selective autophagy of the endoplasmic reticulum. Autophagy. 3: 285-7. PMID 17351330 DOI: 10.4161/Auto.3930  0.756
2007 Heiman MG, Engel A, Walter P. The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating. The Journal of Cell Biology. 176: 209-22. PMID 17210951 DOI: 10.1083/Jcb.200609182  0.716
2007 Aguilar PS, Engel A, Walter P. The plasma membrane proteins Prm1 and Fig1 ascertain fidelity of membrane fusion during yeast mating. Molecular Biology of the Cell. 18: 547-56. PMID 17151357 DOI: 10.1091/Mbc.E06-09-0776  0.619
2007 Walter P, Ansari S, Helms V. The ABC (Analysing Biomolecular Contacts)-database Journal of Integrative Bioinformatics. 4. DOI: 10.1515/Jib-2007-50  0.357
2007 Braunstein M, Scott C, Berman S, Walter P, Wipf P, Brodsky J, Batuman O. In Vitro Antimyeloma Effects of Inhibitors of the Heat Shock Protein 70 (Hsp70) Molecular Chaperone. Blood. 110: 1524-1524. DOI: 10.1182/Blood.V110.11.1524.1524  0.303
2006 Bernales S, McDonald KL, Walter P. Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. Plos Biology. 4: e423. PMID 17132049 DOI: 10.1371/Journal.Pbio.0040423  0.769
2006 Bernales S, Papa FR, Walter P. Intracellular signaling by the unfolded protein response. Annual Review of Cell and Developmental Biology. 22: 487-508. PMID 16822172 DOI: 10.1146/Annurev.Cellbio.21.122303.120200  0.824
2006 Walther TC, Brickner JH, Aguilar PS, Bernales S, Pantoja C, Walter P. Eisosomes mark static sites of endocytosis. Nature. 439: 998-1003. PMID 16496001 DOI: 10.1038/Nature04472  0.818
2006 Braunstein MJ, Liu N, Klueppelberg U, Scott C, Behrman S, Tamucin C, Walter P, Wipf P, Brodsky J, Batuman O. Differential Effects of Hsp70 Inhibition within the Tumor and Microenvironment in Multiple Myeloma. Blood. 108: 5070-5070. DOI: 10.1182/Blood.V108.11.5070.5070  0.799
2005 Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America. 102: 18773-84. PMID 16365312 DOI: 10.1073/Pnas.0509487102  0.732
2005 Kaiser SE, Brickner JH, Reilein AR, Fenn TD, Walter P, Brunger AT. Structural basis of FFAT motif-mediated ER targeting. Structure (London, England : 1993). 13: 1035-45. PMID 16004875 DOI: 10.1016/j.str.2005.04.010  0.706
2005 Egea PF, Stroud RM, Walter P. Targeting proteins to membranes: structure of the signal recognition particle. Current Opinion in Structural Biology. 15: 213-20. PMID 15837181 DOI: 10.1016/J.Sbi.2005.03.007  0.812
2005 Shan SO, Walter P. Molecular crosstalk between the nucleotide specificity determinant of the SRP GTPase and the SRP receptor. Biochemistry. 44: 6214-22. PMID 15835909 DOI: 10.1021/Bi0500980  0.602
2005 Shan SO, Walter P. Co-translational protein targeting by the signal recognition particle. Febs Letters. 579: 921-6. PMID 15680975 DOI: 10.1016/J.Febslet.2004.11.049  0.618
2005 Niwa M, Patil CK, DeRisi J, Walter P. Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease. Genome Biology. 6: R3. PMID 15642095 DOI: 10.1186/Gb-2004-6-1-R3  0.765
2004 Chu F, Shan SO, Moustakas DT, Alber F, Egea PF, Stroud RM, Walter P, Burlingame AL. Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 101: 16454-9. PMID 15546976 DOI: 10.1073/Pnas.0407456101  0.798
2004 Brickner JH, Walter P. Gene recruitment of the activated INO1 locus to the nuclear membrane. Plos Biology. 2: e342. PMID 15455074 DOI: 10.1371/Journal.Pbio.0020342  0.698
2004 Shan SO, Stroud RM, Walter P. Mechanism of association and reciprocal activation of two GTPases. Plos Biology. 2: e320. PMID 15383838 DOI: 10.1371/Journal.Pbio.0020320  0.674
2004 Patil CK, Li H, Walter P. Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response. Plos Biology. 2: E246. PMID 15314660 DOI: 10.1371/Journal.Pbio.0020246  0.785
2004 Leber JH, Bernales S, Walter P. IRE1-independent gain control of the unfolded protein response. Plos Biology. 2: E235. PMID 15314654 DOI: 10.1371/Journal.Pbio.0020235  0.808
2004 Shamu CE, Cox JS, Walter P. The unfolded-protein-response pathway in yeast. Trends in Cell Biology. 4: 56-60. PMID 14731868 DOI: 10.1016/0962-8924(94)90011-6  0.721
2004 Egea PF, Shan SO, Napetschnig J, Savage DF, Walter P, Stroud RM. Substrate twinning activates the signal recognition particle and its receptor. Nature. 427: 215-21. PMID 14724630 DOI: 10.1038/Nature02250  0.825
2003 Papa FR, Zhang C, Shokat K, Walter P. Bypassing a kinase activity with an ATP-competitive drug. Science (New York, N.Y.). 302: 1533-7. PMID 14564015 DOI: 10.1126/Science.1090031  0.576
2003 Shan SO, Walter P. Induced nucleotide specificity in a GTPase. Proceedings of the National Academy of Sciences of the United States of America. 100: 4480-5. PMID 12663860 DOI: 10.1073/Pnas.0737693100  0.606
2002 Ramirez UD, Minasov G, Focia PJ, Stroud RM, Walter P, Kuhn P, Freymann DM. Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh. Journal of Molecular Biology. 320: 783-99. PMID 12095255 DOI: 10.1016/S0022-2836(02)00476-X  0.792
2002 Helenius J, Ng DT, Marolda CL, Walter P, Valvano MA, Aebi M. Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature. 415: 447-50. PMID 11807558 DOI: 10.1038/415447A  0.752
2001 Peluso P, Shan SO, Nock S, Herschlag D, Walter P. Role of SRP RNA in the GTPase cycles of Ffh and FtsY. Biochemistry. 40: 15224-33. PMID 11735405 DOI: 10.1021/Bi011639Y  0.801
2001 Rüegsegger U, Leber JH, Walter P. Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response. Cell. 107: 103-14. PMID 11595189 DOI: 10.1016/S0092-8674(01)00505-0  0.802
2001 Nock S, Gonzalez TN, Sidrauski C, Niwa M, Walter P. Purification and activity assays of the catalytic domains of the kinase/endoribonuclease Ire1p from Saccharomyces cerevisiae. Methods in Enzymology. 342: 3-10. PMID 11586903 DOI: 10.1016/S0076-6879(01)42530-4  0.784
2001 Keenan RJ, Freymann DM, Stroud RM, Walter P. The signal recognition particle. Annual Review of Biochemistry. 70: 755-75. PMID 11395422 DOI: 10.1146/Annurev.Biochem.70.1.755  0.817
2001 Patil C, Walter P. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Current Opinion in Cell Biology. 13: 349-55. PMID 11343907 DOI: 10.1016/S0955-0674(00)00219-2  0.431
2001 Dong B, Niwa M, Walter P, Silverman RH. Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p. Rna. 7: 361-373. PMID 11333017 DOI: 10.1017/S1355838201002230  0.341
2001 Gonzalez TN, Walter P. Ire1p: a kinase and site-specific endoribonuclease. Methods in Molecular Biology (Clifton, N.J.). 160: 25-36. PMID 11265288 DOI: 10.1385/1-59259-233-3:025  0.684
2001 Mutka SC, Walter P. Multifaceted physiological response allows yeast to adapt to the loss of the signal recognition particle-dependent protein-targeting pathway. Molecular Biology of the Cell. 12: 577-88. PMID 11251072 DOI: 10.1091/Mbc.12.3.577  0.822
2000 Heiman MG, Walter P. Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating. The Journal of Cell Biology. 151: 719-30. PMID 11062271 DOI: 10.1083/Jcb.151.3.719  0.611
2000 Niwa M, Walter P. Pausing to decide Proceedings of the National Academy of Sciences of the United States of America. 97: 12396-12397. PMID 11058174 DOI: 10.1073/Pnas.250476097  0.469
2000 Ng DT, Spear ED, Walter P. The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control. The Journal of Cell Biology. 150: 77-88. PMID 10893258 DOI: 10.1083/Jcb.150.1.77  0.838
2000 Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS, Walter P. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell. 101: 249-58. PMID 10847680 DOI: 10.1016/S0092-8674(00)80835-1  0.786
2000 Peluso P, Herschlag D, Nock S, Freymann DM, Johnson AE, Walter P. Role of 4.5S RNA in assembly of the bacterial signal recognition particle with its receptor. Science (New York, N.Y.). 288: 1640-3. PMID 10834842 DOI: 10.1126/Science.288.5471.1640  0.814
2000 Walter P, Keenan R, Schmitz U. Perspectives: structural biology. SRP--where the RNA and membrane worlds meet. Science (New York, N.Y.). 287: 1212-3. PMID 10712156 DOI: 10.1126/Science.287.5456.1212  0.529
2000 Anderson D, Walter P. Blobel's nobel: a vision validated. Cell. 99: 557-8. PMID 10612390 DOI: 10.1016/S0092-8674(00)81543-3  0.411
1999 Niwa M, Sidrauski C, Kaufman RJ, Walter P. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell. 99: 691-702. PMID 10619423 DOI: 10.1016/S0092-8674(00)81667-0  0.452
1999 Stroud RM, Walter P. Signal sequence recognition and protein targeting. Current Opinion in Structural Biology. 9: 754-9. PMID 10607673 DOI: 10.1016/S0959-440X(99)00040-8  0.585
1999 Schmitz U, Behrens S, Freymann DM, Keenan RJ, Lukavsky P, Walter P, James TL. Structure of the phylogenetically most conserved domain of SRP RNA. Rna (New York, N.Y.). 5: 1419-29. PMID 10580470 DOI: 10.1017/S1355838299991458  0.767
1999 Ennifar E, Yusupov M, Walter P, Marquet R, Ehresmann B, Ehresmann C, Dumas P. The crystal structure of the dimerization initiation site of genomic HIV-1 RNA reveals an extended duplex with two adenine bulges. Structure (London, England : 1993). 7: 1439-49. PMID 10574792 DOI: 10.1016/S0969-2126(00)80033-7  0.311
1999 Freymann DM, Keenan RJ, Stroud RM, Walter P. Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP. Nature Structural Biology. 6: 793-801. PMID 10426959 DOI: 10.1038/11572  0.787
1999 Schmitz U, James TL, Lukavsky P, Walter P. Structure of the most conserved internal loop in SRP RNA. Nature Structural Biology. 6: 634-8. PMID 10404218 DOI: 10.1038/10683  0.427
1999 Gonzalez TN, Sidrauski C, Dörfler S, Walter P. Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. The Embo Journal. 18: 3119-32. PMID 10357823 DOI: 10.1093/Emboj/18.11.3119  0.758
1999 Barz WP, Walter P. Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins. Molecular Biology of the Cell. 10: 1043-59. PMID 10198056 DOI: 10.1091/Mbc.10.4.1043  0.455
1999 Powers T, Walter P. Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Molecular Biology of the Cell. 10: 987-1000. PMID 10198052 DOI: 10.1091/Mbc.10.4.987  0.427
1999 Arvidson CG, Powers T, Walter P, So M. Neisseria gonorrhoeae PilA is an FtsY homolog. Journal of Bacteriology. 181: 731-9. PMID 9922234 DOI: 10.1128/Jb.181.3.731-739.1999  0.405
1998 Chapman R, Sidrauski C, Walter P. Intracellular Signaling From The Endoplasmic Reticulum To The Nucleus Annual Review of Cell and Developmental Biology. 14: 459-485. PMID 9891790 DOI: 10.1146/Annurev.Cellbio.14.1.459  0.455
1998 Keenan RJ, Freymann DM, Walter P, Stroud RM. Crystal structure of the signal sequence binding subunit of the signal recognition particle. Cell. 94: 181-91. PMID 9695947 DOI: 10.1016/S0092-8674(00)81418-X  0.786
1998 Sidrauski C, Chapman R, Walter P. The unfolded protein response: an intracellular signalling pathway with many surprising features Trends in Cell Biology. 8: 245-249. PMID 9695849 DOI: 10.1016/S0962-8924(98)01267-7  0.464
1998 Ogg SC, Barz WP, Walter P. A functional GTPase domain, but not its transmembrane domain, is required for function of the SRP receptor beta-subunit. The Journal of Cell Biology. 142: 341-54. PMID 9679135 DOI: 10.1083/Jcb.142.2.341  0.478
1998 Kremerskothen J, Zopf D, Walter P, Cheng JG, Nettermann M, Niewerth U, Maraia RJ, Brosius J. Heterodimer SRP9/14 is an integral part of the neural BC200 RNP in primate brain. Neuroscience Letters. 245: 123-6. PMID 9605471 DOI: 10.1016/S0304-3940(98)00215-8  0.385
1998 Chapman RE, Walter P. Translational attenuation mediated by an mRNA intron. Current Biology : Cb. 7: 850-9. PMID 9382810 DOI: 10.1016/S0960-9822(06)00373-3  0.437
1997 Powers T, Walter P. A ribosome at the end of the tunnel. Science (New York, N.Y.). 278: 2072-3. PMID 9432719 DOI: 10.1126/Science.278.5346.2072  0.412
1997 Sidrauski C, Walter P. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell. 90: 1031-9. PMID 9323131 DOI: 10.1016/S0092-8674(00)80369-4  0.464
1997 Cox JS, Chapman RE, Walter P. The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane. Molecular Biology of the Cell. 8: 1805-14. PMID 9307975 DOI: 10.1091/Mbc.8.9.1805  0.721
1997 Powers T, Walter P. Co-translational protein targeting catalyzed by the Escherichia coli signal recognition particle and its receptor. The Embo Journal. 16: 4880-6. PMID 9305630 DOI: 10.1093/Emboj/16.16.4880  0.473
1997 Nunnari J, Marshall WF, Straight A, Murray A, Sedat JW, Walter P. Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA. Molecular Biology of the Cell. 8: 1233-42. PMID 9243504 DOI: 10.1091/Mbc.8.7.1233  0.617
1997 Freymann DM, Keenan RJ, Stroud RM, Walter P. Structure of the conserved GTPase domain of the signal recognition particle. Nature. 385: 361-4. PMID 9002524 DOI: 10.1038/385361A0  0.805
1996 Schmitz U, Freymann DM, James TL, Keenan RJ, Vinayak R, Walter P. NMR studies of the most conserved RNA domain of the mammalian signal recognition particle (SRP). Rna (New York, N.Y.). 2: 1213-27. PMID 8972771  0.737
1996 Sidrauski C, Cox JS, Walter P. tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell. 87: 405-13. PMID 8898194 DOI: 10.1016/S0092-8674(00)81361-6  0.698
1996 Cox JS, Walter P. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell. 87: 391-404. PMID 8898193 DOI: 10.1016/S0092-8674(00)81360-4  0.714
1996 Powers T, Walter P. The nascent polypeptide-associated complex modulates interactions between the signal recognition particle and the ribosome. Current Biology : Cb. 6: 331-8. PMID 8805251 DOI: 10.1016/S0960-9822(02)00484-0  0.428
1996 Ng DT, Brown JD, Walter P. Signal sequences specify the targeting route to the endoplasmic reticulum membrane. The Journal of Cell Biology. 134: 269-78. PMID 8707814 DOI: 10.1083/Jcb.134.2.269  0.739
1996 Ng DT, Walter P. ER membrane protein complex required for nuclear fusion. The Journal of Cell Biology. 132: 499-509. PMID 8647883 DOI: 10.1083/Jcb.132.4.499  0.743
1996 Powers T, Walter P. Protein targeting. The ribosome talks back. Nature. 381: 191-2. PMID 8622754 DOI: 10.1038/381191A0  0.386
1996 Nunnari J, Walter P. Regulation of organelle biogenesis. Cell. 84: 389-94. PMID 8608592 DOI: 10.1016/S0092-8674(00)81283-0  0.571
1996 Freymann D, Keenan R, Stroud R, Walter P. Progress torwards the crystal structure of Ffh, the bacterial homolog of SRP54 Acta Crystallographica Section a Foundations of Crystallography. 52: C167-C167. DOI: 10.1107/S0108767396092574  0.744
1996 Shamu CE, Walter P. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. The Embo Journal. 15: 3028-3039. DOI: 10.1002/J.1460-2075.1996.Tb00666.X  0.5
1995 Brown JD, NG DT, Ogg SC, Walter P. Targeting pathways to the endoplasmic reticulum membrane. Cold Spring Harbor Symposia On Quantitative Biology. 60: 23-30. PMID 8824374 DOI: 10.1101/Sqb.1995.060.01.005  0.711
1995 Miller JD, Tajima S, Lauffer L, Walter P. The β subunit of the signal recognition particle receptor is a transmembrane GTpase that anchors the α subunit, a peripheral membrane GTpase, to the endoplasmic reticulum membrane Journal of Cell Biology. 128: 273-282. PMID 7844142 DOI: 10.1083/Jcb.128.3.273  0.428
1995 Young JC, Ursini J, Legate KR, Miller JD, Walter P, Andrews DW. An amino-terminal domain containing hydrophobic and hydrophilic sequences binds the signal recognition particle receptor alpha subunit to the beta subunit on the endoplasmic reticulum membrane. The Journal of Biological Chemistry. 270: 15650-7. PMID 7797564 DOI: 10.1074/Jbc.270.26.15650  0.769
1995 Powers T, Walter P. Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases. Science (New York, N.Y.). 269: 1422-4. PMID 7660124 DOI: 10.1126/Science.7660124  0.408
1995 Ogg SC, Walter P. SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation. Cell. 81: 1075-84. PMID 7600575 DOI: 10.1016/S0092-8674(05)80012-1  0.432
1994 Miller JD, Bernstein HD, Walter P. Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor. Nature. 367: 657-9. PMID 8107852 DOI: 10.1038/367657A0  0.454
1994 Selinger D, Brennwald P, Althoff S, Reich C, Hann B, Walter P, Wise JA. Genetic and biochemical analysis of the fission yeast ribonucleoprotein particle containing a homolog of Srp54p. Nucleic Acids Research. 22: 2557-67. PMID 8041618 DOI: 10.1093/Nar/22.13.2557  0.412
1994 Ng DT, Walter P. Protein translocation across the endoplasmic reticulum. Current Opinion in Cell Biology. 6: 510-6. PMID 7986526 DOI: 10.1016/0955-0674(94)90069-8  0.758
1994 Walter P, Johnson AE. Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane Annual Review of Cell Biology. 10: 87-119. PMID 7888184 DOI: 10.1146/Annurev.Cb.10.110194.000511  0.416
1994 Brown J, Hann B, Medzihradszky K, Niwa M, Burlingame A, Walter P. Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression. The Embo Journal. 13: 4390-4400. DOI: 10.1002/J.1460-2075.1994.Tb06759.X  0.49
1993 Cox JS, Shamu CE, Walter P. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell. 73: 1197-206. PMID 8513503 DOI: 10.1016/0092-8674(93)90648-A  0.736
1993 Wolin SL, Walter P. Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes. The Journal of Cell Biology. 121: 1211-9. PMID 8389768 DOI: 10.1083/Jcb.121.6.1211  0.465
1993 Bernstein HD, Zopf D, Freymann DM, Walter P. Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog. Proceedings of the National Academy of Sciences of the United States of America. 90: 5229-33. PMID 8389475 DOI: 10.1073/Pnas.90.11.5229  0.77
1993 Zopf D, Bernstein HD, Walter P. GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding. The Journal of Cell Biology. 120: 1113-21. PMID 8382204 DOI: 10.1083/Jcb.120.5.1113  0.426
1993 Nunnari J, Fox TD, Walter P. A mitochondrial protease with two catalytic subunits of nonoverlapping specificities Science. 262: 1997-2004. PMID 8266095 DOI: 10.1126/Science.8266095  0.668
1993 Miller JD, Wilhelm H, Gierasch L, Gilmore R, Walter P. GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation. Nature. 366: 351-4. PMID 8247130 DOI: 10.1038/366351A0  0.631
1992 Green N, Fang H, Walter P. Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiae. The Journal of Cell Biology. 116: 597-604. PMID 1730771 DOI: 10.1083/Jcb.116.3.597  0.453
1992 Green N, Walter P. C-terminal sequences can inhibit the insertion of membrane proteins into the endoplasmic reticulum of Saccharomyces cerevisiae. Molecular and Cellular Biology. 12: 276-82. PMID 1729604 DOI: 10.1128/Mcb.12.1.276  0.449
1992 Nunnari J, Walter P. Protein targeting to and translocation across the membrane of the endoplasmic reticulum. Current Opinion in Cell Biology. 4: 573-80. PMID 1419037 DOI: 10.1016/0955-0674(92)90074-M  0.693
1992 Janiak F, Walter P, Johnson AE. Fluorescence-detected assembly of the signal recognition particle: Binding of the two SRP protein heterodimers to SRP RNA is noncooperative Biochemistry. 31: 5830-5840. PMID 1377027 DOI: 10.1021/Bi00140A019  0.367
1992 Ogg SC, Poritz MA, Walter P. Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae. Molecular Biology of the Cell. 3: 895-911. PMID 1327299 DOI: 10.1091/Mbc.3.8.895  0.446
1992 Walter P. Protein translocation. Travelling by TRAM. Nature. 357: 22-3. PMID 1315419 DOI: 10.1038/357022A0  0.393
1992 Hann BC, Stirling CJ, Walter P. SEC65 gene product is a subunit of the yeast signal recognition particle required for its integrity Nature. 356: 532-533. PMID 1313947 DOI: 10.1038/356532A0  0.445
1992 Ogg SC, Nunnari JM, Miller JD, Walter P. Chapter 11 The role of GTP in protein targeting to the endoplasmic reticulum New Comprehensive Biochemistry. 22: 129-136. DOI: 10.1016/S0167-7306(08)60088-5  0.69
1992 Hann B, Walter P. The signal recognition particle in S. cerevisiae Trends in Cell Biology. 2: 9. DOI: 10.1016/0962-8924(92)90134-9  0.492
1991 Garcia PD, Hansen W, Walter P. In vitro protein translocation across microsomal membranes of Saccharomyces cerevisiae. Methods in Enzymology. 194: 675-82. PMID 2005815 DOI: 10.1016/0076-6879(91)94049-I  0.373
1991 Thrift RN, Andrews DW, Walter P, Johnson AE. A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation. The Journal of Cell Biology. 112: 809-21. PMID 1999459 DOI: 10.1083/Jcb.112.5.809  0.611
1991 Zimmerman DL, Walter P. An ATP-binding membrane protein is required for protein translocation across the endoplasmic reticulum membrane. Cell Regulation. 2: 851-9. PMID 1801920 DOI: 10.1091/Mbc.2.10.851  0.448
1991 Strub K, Moss J, Walter P. Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution. Molecular and Cellular Biology. 11: 3949-3959. PMID 1712900 DOI: 10.1128/Mcb.11.8.3949  0.441
1991 Brennwald PJ, Siegel V, Walter P, Wise JA. Sequence and structure of Tetrahymena SRP RNA. Nucleic Acids Research. 19: 1942. PMID 1709498 DOI: 10.1093/Nar/19.8.1942  0.616
1991 Hann BC, Walter P. The signal recognition particle in S. cerevisiae. Cell. 67: 131-44. PMID 1655273 DOI: 10.1016/0092-8674(91)90577-L  0.492
1991 Nunnari JM, Zimmerman DL, Ogg SC, Walter P. Characterization of the rough endoplasmic reticulum ribosome-binding activity Nature. 352: 638-640. PMID 1650916 DOI: 10.1038/352638A0  0.669
1991 Nunnari J, Zimmerman D, Ogg S, Walter P. Characterization of the rough endoplasmic reticulum ribosome-binding activity Trends in Cell Biology. 1: 115. DOI: 10.1016/0962-8924(91)90110-U  0.588
1990 Green GN, Hansen W, Walter P. The use of gene-fusions to determine membrane protein topology in Saccharomyces cerevisiae. Journal of Cell Science. Supplement. 11: 109-13. PMID 2693456 DOI: 10.1242/Jcs.1989.Supplement_11.9  0.411
1990 Strub K, Walter P. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. Molecular and Cellular Biology. 10: 777-84. PMID 2153922 DOI: 10.1128/Mcb.10.2.777  0.462
1990 Poritz MA, Bernstein HD, Strub K, Zopf D, Wilhelm H, Walter P. An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle. Science (New York, N.Y.). 250: 1111-7. PMID 1701272 DOI: 10.1126/Science.1701272  0.413
1990 Zopf D, Bernstein HD, Johnson AE, Walter P. The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence. The Embo Journal. 9: 4511-4517. DOI: 10.1002/J.1460-2075.1990.Tb07902.X  0.356
1989 Krieg UC, Johnson AE, Walter P. Protein translocation across the endoplasmic reticulum membrane: Identification by photocross-linking of a 39-kD integral membrane glycoprotein as part of a putative translocation tunnel Journal of Cell Biology. 109: 2033-2043. PMID 2808520 DOI: 10.1083/Jcb.109.5.2033  0.449
1989 Siegel V, Walter P. Assembly of proteins in the endoplasmic reticulum. Current Opinion in Cell Biology. 1: 635-8. PMID 2697275 DOI: 10.1016/0955-0674(89)90027-6  0.68
1989 Ngsee JK, Hansen W, Walter P, Smith M. Cassette mutagenic analysis of the yeast invertase signal peptide: effects on protein translocation. Molecular and Cellular Biology. 9: 3400-10. PMID 2677671 DOI: 10.1128/Mcb.9.8.3400  0.332
1989 Hann BC, Poritz MA, Walter P. Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth. Journal of Cell Biology. 109: 3223-3230. PMID 2557350 DOI: 10.1083/Jcb.109.6.3223  0.382
1989 Wolin SL, Walter P. Signal recognition particle mediates a transient elongation arrest of preprolactin in reticulocyte lysate. The Journal of Cell Biology. 109: 2617-22. PMID 2556403 DOI: 10.1083/Jcb.109.6.2617  0.47
1989 Bernstein HD, Rapoport TA, Walter P. Cytosolic protein translocation factors. Is SRP still unique? Cell. 58: 1017-9. PMID 2550141 DOI: 10.1016/0092-8674(89)90497-2  0.381
1989 Andrews DW, Lauffer L, Walter P, Lingappa VR. Evidence for a two-step mechanism involved in assembly of functional signal recognition particle receptor. The Journal of Cell Biology. 108: 797-810. PMID 2537835 DOI: 10.1083/Jcb.108.3.797  0.742
1989 Bernstein HD, Poritz MA, Strub K, Hoben PJ, Brenner S, Walter P. Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Nature. 340: 482-6. PMID 2502718 DOI: 10.1038/340482A0  0.433
1989 Walter P. The Membranes of a Eukaryotic Cell Integrative and Comparative Biology. 29: 501-510. DOI: 10.1093/Icb/29.2.501  0.356
1988 Garcia PD, Ou JH, Rutter WJ, Walter P. Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. The Journal of Cell Biology. 106: 1093-104. PMID 3283145 DOI: 10.1083/Jcb.106.4.1093  0.452
1988 Hansen W, Walter P. Prepro-carboxypeptidase Y and a truncated form of pre-invertase, but not full-length pre-invertase, can be posttranslationally translocated across microsomal vesicle membranes from Saccharomyces cerevisiae. The Journal of Cell Biology. 106: 1075-81. PMID 3283144 DOI: 10.1083/Jcb.106.4.1075  0.456
1988 Siegel V, Walter P. The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length. The Embo Journal. 7: 1769-75. PMID 3169004 DOI: 10.1002/J.1460-2075.1988.Tb03007.X  0.673
1988 Kassenbrock CK, Garcia PD, Walter P, Kelly RB. Heavy-chain binding protein recognizes aberrant polypeptides translocated in vitro. Nature. 333: 90-3. PMID 3129663 DOI: 10.1038/333090A0  0.424
1988 Siegel V, Walter P. Functional dissection of the signal recognition particle. Trends in Biochemical Sciences. 13: 314-6. PMID 2856455 DOI: 10.1016/0968-0004(88)90127-2  0.672
1988 Poritz MA, Siegel V, Hansen W, Walter P. Small ribonucleoproteins in Schizosaccharomyces pombe and Yarrowia lipolytica homologous to signal recognition particle. Proceedings of the National Academy of Sciences of the United States of America. 85: 4315-9. PMID 2837764 DOI: 10.1073/Pnas.85.12.4315  0.664
1988 Garcia PD, Walter P. Full-length prepro-alpha-factor can be translocated across the mammalian microsomal membrane only if translation has not terminated. The Journal of Cell Biology. 106: 1043-8. PMID 2834400 DOI: 10.1083/Jcb.106.4.1043  0.344
1988 Siegel V, Walter P. Each of the activities of signal recognition particle (SRP) is contained within a distinct domain: analysis of biochemical mutants of SRP. Cell. 52: 39-49. PMID 2830980 DOI: 10.1016/0092-8674(88)90529-6  0.705
1988 Lingelbach K, Zwieb C, Webb JR, Marshallsay C, Hoben PJ, Walter P, Dobberstein B. Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. Nucleic Acids Research. 16: 9431-42. PMID 2460823 DOI: 10.1093/Nar/16.20.9431  0.389
1988 Siegel V, Walter P. Binding sites of the 19-kDa and 68/72-kDa signal recognition particle (SRP) proteins on SRP RNA as determined in protein-RNA "footprinting". Proceedings of the National Academy of Sciences of the United States of America. 85: 1801-5. PMID 2450348 DOI: 10.1073/Pnas.85.6.1801  0.694
1987 Andrews DW, Walter P, Ottensmeyer FP. Evidence for an extended 7SL RNA structure in the signal recognition particle. The Embo Journal. 6: 3471-7. PMID 2828031 DOI: 10.1002/J.1460-2075.1987.Tb02671.X  0.527
1987 Rapoport TA, Heinrich R, Walter P, Schulmeister T. Mathematical modeling of the effects of the signal recognition particle on translation and translocation of proteins across the endoplasmic reticulum membrane. Journal of Molecular Biology. 195: 621-36. PMID 2821280 DOI: 10.1016/0022-2836(87)90186-0  0.456
1987 Siegel V, Garcia PD, Walter P. Substrate requirements for SRP-mediated targeting to the ER membrane Molecular Biology Reports. 12: 219. DOI: 10.1007/Bf00356909  0.669
1986 Krieg UC, Walter P, Johnson AE. Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle Proceedings of the National Academy of Sciences of the United States of America. 83: 8604-8608. PMID 3095839 DOI: 10.1073/Pnas.83.22.8604  0.466
1986 Walter P, Lingappa VR. Mechanism of protein translocation across the endoplasmic reticulum membrane. Annual Review of Cell Biology. 2: 499-516. PMID 3030381 DOI: 10.1146/Annurev.Cb.02.110186.002435  0.666
1986 Tajima S, Lauffer L, Rath VL, Walter P. The signal recognition particle receptor is a complex that contains two distinct polypeptide chains Journal of Cell Biology. 103: 1167-1178. PMID 3021779 DOI: 10.1083/Jcb.103.4.1167  0.377
1986 Hansen W, Garcia PD, Walter P. In vitro protein translocation across the yeast endoplasmic reticulum: ATP-dependent posttranslational translocation of the prepro-alpha-factor. Cell. 45: 397-406. PMID 3009026 DOI: 10.1016/0092-8674(86)90325-9  0.339
1986 Siegel V, Walter P. Removal of the Alu structural domain from signal recognition particle leaves its protein translocation activity intact. Nature. 320: 81-4. PMID 2419765 DOI: 10.1038/320081A0  0.68
1985 Andrews DW, Walter P, Ottensmeyer FP. Structure of the signal recognition particle by electron microscopy. Proceedings of the National Academy of Sciences of the United States of America. 82: 785-9. PMID 3856232 DOI: 10.1073/Pnas.82.3.785  0.531
1985 Lauffer L, Garcia PD, Harkins RN, Coussens L, Ullrich A, Walter P. Topology of signal recognition particle receptor in endoplasmic reticulum membrane. Nature. 318: 334-8. PMID 2999608 DOI: 10.1038/318334A0  0.428
1985 Siegel V, Walter P. Elongation arrest is not a prerequisite for secretory protein translocation across the microsomal membrane. The Journal of Cell Biology. 100: 1913-21. PMID 2581979 DOI: 10.1083/Jcb.100.6.1913  0.721
1984 Bonatti S, Migliaccio G, Blobel G, Walter P. Role of signal recognition particle in the membrane assembly of Sindbis viral glycoproteins. European Journal of Biochemistry / Febs. 140: 499-502. PMID 6723645 DOI: 10.1111/J.1432-1033.1984.Tb08130.X  0.575
1984 Blobel G, Walter P, Gilmore R. Intracellular protein topogenesis. Progress in Clinical and Biological Research. 168: 3-10. PMID 6514738  0.649
1984 Walter P, Gilmore R, Blobel G. Protein translocation across the endoplasmic reticulum. Cell. 38: 5-8. PMID 6088076 DOI: 10.1016/0092-8674(84)90520-8  0.695
1983 Walter P, Blobel G. Preparation of microsomal membranes for cotranslational protein translocation. Methods in Enzymology. 96: 84-93. PMID 6656655 DOI: 10.1016/S0076-6879(83)96010-X  0.574
1983 Walter P, Blobel G. Disassembly and reconstitution of signal recognition particle. Cell. 34: 525-33. PMID 6413076 DOI: 10.1016/0092-8674(83)90385-9  0.592
1983 Walter P, Blobel G. Signal recognition particle: a ribonucleoprotein required for cotranslational translocation of proteins, isolation and properties. Methods in Enzymology. 96: 682-91. PMID 6197610 DOI: 10.1016/S0076-6879(83)96057-3  0.608
1983 Walter P, Blobel G. Subcellular distribution of signal recognition particle and 7SL-RNA determined with polypeptide-specific antibodies and complementary DNA probe. The Journal of Cell Biology. 97: 1693-9. PMID 6196367 DOI: 10.1083/Jcb.97.6.1693  0.567
1983 Erickson AH, Walter P, Blobel G. Translocation of a lysosomal enzyme across the microsomal membrane requires signal recognition particle. Biochemical and Biophysical Research Communications. 115: 275-80. PMID 6137219 DOI: 10.1016/0006-291X(83)91000-8  0.574
1982 Walter P, Blobel G. Translocation of proteins across the endoplasmic reticulum. Oncodevelopmental Biology and Medicine : the Journal of the International Society For Oncodevelopmental Biology and Medicine. 4: 137-46. PMID 7177879  0.53
1982 Anderson DJ, Walter P, Blobel G. Signal recognition protein is required for the integration of acetylcholine receptor delta subunit, a transmembrane glycoprotein, into the endoplasmic reticulum membrane. The Journal of Cell Biology. 93: 501-6. PMID 7047541 DOI: 10.1083/Jcb.93.2.501  0.657
1982 Müller M, Ibrahimi I, Chang CN, Walter P, Blobel G. A bacterial secretory protein requires signal recognition particle for translocation across mammalian endoplasmic reticulum. The Journal of Biological Chemistry. 257: 11860-3. PMID 6749848  0.521
1982 Gilmore R, Walter P, Blobel G. Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor. The Journal of Cell Biology. 95: 470-7. PMID 6292236 DOI: 10.1083/Jcb.95.2.470  0.701
1982 Gilmore R, Blobel G, Walter P. Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. The Journal of Cell Biology. 95: 463-9. PMID 6292235 DOI: 10.1083/Jcb.95.2.463  0.661
1982 Walter P, Blobel G. Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum. Nature. 299: 691-8. PMID 6181418 DOI: 10.1038/299691A0  0.595
1982 Walter P, Gilmore R, Müller M, Blobel G. The protein translocation machinery of the endoplasmic reticulum. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 300: 225-8. PMID 6131460 DOI: 10.1098/Rstb.1982.0168  0.678
1982 Walter P, Blobel G. Mechanism of protein translocation across the endoplasmic reticulum. Biochemical Society Symposium. 47: 183-91. PMID 6100822  0.516
1981 Walter P, Blobel G. Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes. The Journal of Cell Biology. 91: 557-61. PMID 7309797 DOI: 10.1083/Jcb.91.2.557  0.584
1981 Walter P, Blobel G. Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein. The Journal of Cell Biology. 91: 551-6. PMID 7309796 DOI: 10.1083/Jcb.91.2.551  0.621
1981 Walter P, Ibrahimi I, Blobel G. Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. The Journal of Cell Biology. 91: 545-50. PMID 7309795 DOI: 10.1083/Jcb.91.2.545  0.602
1981 Stoffel W, Blobel G, Walter P. Synthesis in vitro and translocation of apolipoprotein AI across microsomal vesicles. European Journal of Biochemistry / Febs. 120: 519-22. PMID 6174327 DOI: 10.1111/J.1432-1033.1981.Tb05730.X  0.557
1980 Jackson RC, Walter P, Blobel G. Secretion requires a cytoplasmically disposed sulphydryl of the RER membrane. Nature. 286: 174-6. PMID 6995850 DOI: 10.1038/286174A0  0.535
1980 Walter P, Blobel G. Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America. 77: 7112-6. PMID 6938958 DOI: 10.1073/Pnas.77.12.7112  0.543
1979 Blobel G, Walter P, Chang CN, Goldman BM, Erickson AH, Lingappa VR. Translocation of proteins across membranes: the signal hypothesis and beyond. Symposia of the Society For Experimental Biology. 33: 9-36. PMID 524275  0.712
1979 Walter P, Jackson RC, Marcus MM, Lingappa VR, Blobel G. Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes. Proceedings of the National Academy of Sciences of the United States of America. 76: 1795-9. PMID 109833 DOI: 10.1073/Pnas.76.4.1795  0.724
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