Natalie Strynadka - Publications

Affiliations: 
Biochemistry and Molecular Biology University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
structure-based design of novel, therapeutically useful antibiotics and inhibitors of antibiotic-resistance mechanisms
Website:
http://www.biochem.ubc.ca/faculty/natalie-strynadka/

121 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Caveney NA, Workman SD, Yan R, Atkinson CE, Yu Z, Strynadka NCJ. CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution. Nature Communications. 12: 2775. PMID 33986273 DOI: 10.1038/s41467-021-23063-6  0.783
2021 Li FKK, Gale RT, Petrotchenko EV, Borchers CH, Brown ED, Strynadka NCJ. Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis. Journal of Structural Biology. 107733. PMID 33819634 DOI: 10.1016/j.jsb.2021.107733  0.363
2021 Lyons BJE, Atkinson CE, Deng W, Serapio-Palacios A, Finlay BB, Strynadka NCJ. Cryo-EM structure of the EspA filament from enteropathogenic Escherichia coli: revealing the mechanism of effector translocation in the T3SS. Structure (London, England : 1993). PMID 33453150 DOI: 10.1016/j.str.2020.12.009  0.353
2020 Lee J, Worrall LJ, Vuckovic M, Rosell FI, Gentile F, Ton AT, Caveney NA, Ban F, Cherkasov A, Paetzel M, Strynadka NCJ. Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site. Nature Communications. 11: 5877. PMID 33208735 DOI: 10.1038/s41467-020-19662-4  0.77
2020 Pazos M, Peters K, Boes A, Safaei Y, Kenward C, Caveney NA, Laguri C, Breukink E, Strynadka NCJ, Simorre JP, Terrak M, Vollmer W. SPOR Proteins Are Required for Functionality of Class A Penicillin-Binding Proteins in Escherichia coli. Mbio. 11. PMID 33144379 DOI: 10.1128/mBio.02796-20  0.778
2020 Majewski DD, Lyons BJE, Atkinson CE, Strynadka NCJ. Cryo-EM analysis of the SctV cytosolic domain from the enteropathogenic E. coli T3SS injectisome. Journal of Structural Biology. 212: 107660. PMID 33129970 DOI: 10.1016/j.jsb.2020.107660  0.417
2020 Majewski DD, Okon M, Heinkel F, Robb CS, Vuckovic M, McIntosh LP, Strynadka NCJ. Characterization of the Pilotin-Secretin Complex from the Salmonella enterica Type III Secretion System Using Hybrid Structural Methods. Structure (London, England : 1993). PMID 32877645 DOI: 10.1016/J.Str.2020.08.006  0.326
2020 Alexander JAN, Radaeva M, King DT, Chambers HF, Cherkasov A, Chatterjee SS, Strynadka NCJ. -Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant . The Journal of Biological Chemistry. PMID 32518158 DOI: 10.1074/Jbc.Ra120.013029  0.309
2020 Caveney NA, Egan AJF, Ayala I, Laguri C, Robb CS, Breukink E, Vollmer W, Strynadka NCJ, Simorre JP. Structure of the Peptidoglycan Synthase Activator LpoP in Pseudomonas aeruginosa. Structure (London, England : 1993). PMID 32320673 DOI: 10.1016/j.str.2020.03.012  0.79
2020 Li FKK, Rosell FI, Gale RT, Simorre JP, Brown ED, Strynadka NCJ. Crystallographic analysis of LcpA, the primary wall teichoic acid ligase. The Journal of Biological Chemistry. PMID 31969390 DOI: 10.1074/jbc.RA119.011469  0.375
2019 Hu J, Worrall LJ, Strynadka NC. Towards capture of dynamic assembly and action of the T3SS at near atomic resolution. Current Opinion in Structural Biology. 61: 71-78. PMID 31821956 DOI: 10.1016/j.sbi.2019.10.005  0.316
2019 Lyons BJE, Strynadka NCJ. On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome. Medchemcomm. 10: 1273-1289. PMID 31534650 DOI: 10.1039/c9md00146h  0.308
2019 Hu J, Worrall LJ, Vuckovic M, Hong C, Deng W, Atkinson CE, Brett Finlay B, Yu Z, Strynadka NCJ. T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly. Nature Microbiology. PMID 31427728 DOI: 10.1038/s41564-019-0545-z  0.374
2019 Caveney NA, Pavlin A, Caballero G, Bahun M, Hodnik V, de Castro L, Fornelos N, Butala M, Strynadka NCJ. Structural Insights into Bacteriophage GIL01 gp7 Inhibition of Host LexA Repressor. Structure (London, England : 1993). PMID 31056420 DOI: 10.1016/j.str.2019.03.019  0.757
2019 Caveney NA, Caballero G, Voedts H, Niciforovic A, Worrall LJ, Vuckovic M, Fonvielle M, Hugonnet JE, Arthur M, Strynadka NCJ. Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli. Nature Communications. 10: 1849. PMID 31015395 DOI: 10.1038/s41467-019-09507-0  0.761
2019 Majewski DD, Worrall LJ, Hong C, Atkinson CE, Vuckovic M, Watanabe N, Yu Z, Strynadka NCJ. Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry. Nature Communications. 10: 626. PMID 30733444 DOI: 10.1038/s41467-019-08477-7  0.4
2018 Blaukopf M, Worrall L, Kosma P, Strynadka NCJ, Withers SG. Insights into Heptosyltransferase I Catalysis and Inhibition through the Structure of Its Ternary Complex. Structure (London, England : 1993). PMID 30122450 DOI: 10.1016/J.Str.2018.07.001  0.419
2018 Bergeron JRC, Brockerman JA, Vuckovic M, Deng W, Okon M, Finlay BB, McIntosh LP, Strynadka NCJ. Characterization of the two conformations adopted by the T3SS inner-membrane protein PrgK. Protein Science : a Publication of the Protein Society. PMID 30095200 DOI: 10.1002/Pro.3447  0.376
2018 Caveney NA, Li FK, Strynadka NC. Enzyme structures of the bacterial peptidoglycan and wall teichoic acid biogenesis pathways. Current Opinion in Structural Biology. 53: 45-58. PMID 29885610 DOI: 10.1016/j.sbi.2018.05.002  0.775
2018 Majewski DD, Worrall LJ, Strynadka NC. Secretins revealed: structural insights into the giant gated outer membrane portals of bacteria. Current Opinion in Structural Biology. 51: 61-72. PMID 29579693 DOI: 10.1016/j.sbi.2018.02.008  0.315
2018 Workman SD, Worrall LJ, Strynadka NCJ. Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling. Nature Communications. 9: 1159. PMID 29559664 DOI: 10.1038/s41467-018-03547-8  0.346
2017 Zeytuni N, Hong C, Flanagan KA, Worrall LJ, Theiltges KA, Vuckovic M, Huang RK, Massoni SC, Camp AH, Yu Z, Strynadka NC. Near-atomic resolution cryoelectron microscopy structure of the 30-fold homooligomeric SpoIIIAG channel essential to spore formation in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28784753 DOI: 10.1073/Pnas.1704310114  0.309
2017 Lizak C, Worrall LJ, Baumann L, Pfleiderer MM, Volkers G, Sun T, Sim L, Wakarchuk W, Withers SG, Strynadka NCJ. X-ray crystallographic structure of a bacterial polysialyltransferase provides insight into the biosynthesis of capsular polysialic acid. Scientific Reports. 7: 5842. PMID 28724897 DOI: 10.1038/S41598-017-05627-Z  0.382
2017 Deng W, Marshall NC, Rowland JL, McCoy JM, Worrall LJ, Santos AS, Strynadka NC, Finlay BB. Assembly, structure, function and regulation of type III secretion systems. Nature Reviews. Microbiology. PMID 28392566 DOI: 10.1038/Nrmicro.2017.20  0.342
2016 Sobhanifar S, Worrall LJ, King DT, Wasney GA, Baumann L, Gale RT, Nosella M, Brown ED, Withers SG, Strynadka NC. Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin Resistance. Plos Pathogens. 12: e1006067. PMID 27973583 DOI: 10.1371/Journal.Ppat.1006067  0.377
2016 King DT, Wasney GA, Nosella M, Fong A, Strynadka NC. Escherichia coli Penicillin-Binding Protein 1B: Structural Insights into Inhibition. The Journal of Biological Chemistry. PMID 27899450 DOI: 10.1074/jbc.M116.718403  0.401
2015 Bergeron JR, Fernández L, Wasney GA, Vuckovic M, Reffuveille F, Hancock RE, Strynadka NC. The Structure of a T3SS Ruler Protein Suggests a Molecular Mechanism for Needle Length Sensing. The Journal of Biological Chemistry. PMID 26589798 DOI: 10.1074/jbc.M115.684423  0.378
2015 Burkinshaw BJ, Souza SA, Strynadka NC. Structural analysis of SepL, an enteropathogenic Escherichia coli type III secretion-system gatekeeper protein. Acta Crystallographica. Section F, Structural Biology Communications. 71: 1300-8. PMID 26457522 DOI: 10.1107/S2053230X15016064  0.392
2015 Solomonson M, Setiaputra D, Makepeace KA, Lameignere E, Petrotchenko EV, Conrady DG, Bergeron JR, Vuckovic M, DiMaio F, Borchers CH, Yip CK, Strynadka NC. Structure of EspB from the ESX-1 type VII secretion system and insights into its export mechanism. Structure (London, England : 1993). 23: 571-83. PMID 25684576 DOI: 10.1016/J.Str.2015.01.002  0.62
2015 Burkinshaw BJ, Deng W, Lameignère E, Wasney GA, Zhu H, Worrall LJ, Finlay BB, Strynadka NC. Structural analysis of a specialized type III secretion system peptidoglycan-cleaving enzyme. The Journal of Biological Chemistry. 290: 10406-17. PMID 25678709 DOI: 10.1074/jbc.M115.639013  0.365
2015 Sobhanifar S, Worrall LJ, Gruninger RJ, Wasney GA, Blaukopf M, Baumann L, Lameignere E, Solomonson M, Brown ED, Withers SG, Strynadka NC. Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid α-glycosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 112: E576-85. PMID 25624472 DOI: 10.1073/Pnas.1418084112  0.351
2015 Bergeron JR, Worrall LJ, De S, Sgourakis NG, Cheung AH, Lameignere E, Okon M, Wasney GA, Baker D, McIntosh LP, Strynadka NC. The modular structure of the inner-membrane ring component PrgK facilitates assembly of the type III secretion system basal body. Structure (London, England : 1993). 23: 161-72. PMID 25533490 DOI: 10.1016/J.Str.2014.10.021  0.376
2014 King DT, Lameignere E, Strynadka NC. Structural insights into the lipoprotein outer membrane regulator of penicillin-binding protein 1B. The Journal of Biological Chemistry. 289: 19245-53. PMID 24808177 DOI: 10.1074/jbc.M114.565879  0.418
2014 Burkinshaw BJ, Strynadka NC. Assembly and structure of the T3SS. Biochimica Et Biophysica Acta. 1843: 1649-63. PMID 24512838 DOI: 10.1016/j.bbamcr.2014.01.035  0.315
2014 Volkers G, Worrall L, Lameignere E, Strynadka N. New Insights on Structure and Function of Sialyltransferases Acta Crystallographica Section A. 70. DOI: 10.1107/S2053273314095175  0.319
2014 King D, Strynadka N. Analysis of bacterial cell-wall synthesis to combat antibiotic resistance Acta Crystallographica Section A. 70. DOI: 10.1107/S2053273314092985  0.322
2013 Bergeron JR, Worrall LJ, Sgourakis NG, DiMaio F, Pfuetzner RA, Felise HB, Vuckovic M, Yu AC, Miller SI, Baker D, Strynadka NC. A refined model of the prototypical Salmonella SPI-1 T3SS basal body reveals the molecular basis for its assembly. Plos Pathogens. 9: e1003307. PMID 23633951 DOI: 10.1371/Journal.Ppat.1003307  0.338
2013 Solomonson M, Huesgen PF, Wasney GA, Watanabe N, Gruninger RJ, Prehna G, Overall CM, Strynadka NC. Structure of the mycosin-1 protease from the mycobacterial ESX-1 protein type VII secretion system. The Journal of Biological Chemistry. 288: 17782-90. PMID 23620593 DOI: 10.1074/Jbc.M113.462036  0.408
2013 Sal-Man N, Setiaputra D, Scholz R, Deng W, Yu AC, Strynadka NC, Finlay BB. EscE and EscG are cochaperones for the type III needle protein EscF of enteropathogenic Escherichia coli. Journal of Bacteriology. 195: 2481-9. PMID 23524615 DOI: 10.1128/JB.00118-13  0.33
2013 Strynadka N. Structure-Based Analysis of the Type III Secretion System for Antimicrobial and Vaccine Design Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.2950  0.449
2012 Prehna G, Li Y, Stoynov N, Okon M, Vuckovic M, McIntosh LP, Foster LJ, Finlay BB, Strynadka NC. The zinc regulated antivirulence pathway of Salmonella is a multiprotein immunoglobulin adhesion system. The Journal of Biological Chemistry. 287: 32324-37. PMID 22810234 DOI: 10.1074/Jbc.M112.357210  0.371
2012 King DT, Worrall LJ, Gruninger R, Strynadka NC. New Delhi metallo-β-lactamase: structural insights into β-lactam recognition and inhibition. Journal of the American Chemical Society. 134: 11362-5. PMID 22713171 DOI: 10.1021/ja303579d  0.329
2012 Prehna G, Zhang G, Gong X, Duszyk M, Okon M, McIntosh LP, Weiner JH, Strynadka NC. A protein export pathway involving Escherichia coli porins. Structure (London, England : 1993). 20: 1154-66. PMID 22658749 DOI: 10.1016/J.Str.2012.04.014  0.345
2012 Yu AC, Worrall LJ, Strynadka NC. Structural insight into the bacterial mucinase StcE essential to adhesion and immune evasion during enterohemorrhagic E. coli infection. Structure (London, England : 1993). 20: 707-17. PMID 22483117 DOI: 10.1016/j.str.2012.02.015  0.31
2012 Thanabalasuriar A, Bergeron J, Gillingham A, Mimee M, Thomassin JL, Strynadka N, Kim J, Gruenheid S. Sec24 interaction is essential for localization and virulence-associated function of the bacterial effector protein NleA. Cellular Microbiology. 14: 1206-18. PMID 22432415 DOI: 10.1111/J.1462-5822.2012.01789.X  0.34
2012 Burkinshaw BJ, Prehna G, Worrall LJ, Strynadka NC. Structure of Salmonella effector protein SopB N-terminal domain in complex with host Rho GTPase Cdc42. The Journal of Biological Chemistry. 287: 13348-55. PMID 22362774 DOI: 10.1074/jbc.M111.331330  0.411
2012 Prehna G, Li Y, Stoynov N, Okon M, Vukovic M, McIntosh L, Foster L, Finlay BB, Strynadka N. ZirS C-terminal Domain Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Lv4/Pdb  0.32
2011 Lin LY, Rakic B, Chiu CP, Lameignere E, Wakarchuk WW, Withers SG, Strynadka NC. Structure and mechanism of the lipooligosaccharide sialyltransferase from Neisseria meningitidis. The Journal of Biological Chemistry. 286: 37237-48. PMID 21880735 DOI: 10.1074/Jbc.M111.249920  0.409
2011 Lee HJ, Lairson LL, Rich JR, Lameignere E, Wakarchuk WW, Withers SG, Strynadka NC. Structural and kinetic analysis of substrate binding to the sialyltransferase Cst-II from Campylobacter jejuni. The Journal of Biological Chemistry. 286: 35922-32. PMID 21832050 DOI: 10.1074/Jbc.M111.261172  0.384
2011 King D, Strynadka N. Crystal structure of New Delhi metallo-β-lactamase reveals molecular basis for antibiotic resistance. Protein Science : a Publication of the Protein Society. 20: 1484-91. PMID 21774017 DOI: 10.1002/Pro.697  0.425
2011 Worrall LJ, Lameignere E, Strynadka NC. Structural overview of the bacterial injectisome. Current Opinion in Microbiology. 14: 3-8. PMID 21112241 DOI: 10.1016/j.mib.2010.10.009  0.336
2010 Babu M, Greenblatt JF, Emili A, Strynadka NC, Reithmeier RA, Moraes TF. Structure of a SLC26 anion transporter STAS domain in complex with acyl carrier protein: implications for E. coli YchM in fatty acid metabolism. Structure (London, England : 1993). 18: 1450-62. PMID 21070944 DOI: 10.1016/J.Str.2010.08.015  0.67
2010 Sanowar S, Singh P, Pfuetzner RA, André I, Zheng H, Spreter T, Strynadka NC, Gonen T, Baker D, Goodlett DR, Miller SI. Interactions of the transmembrane polymeric rings of the Salmonella enterica serovar Typhimurium type III secretion system. Mbio. 1. PMID 20824104 DOI: 10.1128/Mbio.00158-10  0.354
2010 Dresen C, Lin LY, D'Angelo I, Tocheva EI, Strynadka N, Eltis LD. A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism. The Journal of Biological Chemistry. 285: 22264-75. PMID 20448045 DOI: 10.1074/Jbc.M109.099028  0.373
2010 Lovering AL, Lin LY, Sewell EW, Spreter T, Brown ED, Strynadka NC. Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis. Nature Structural & Molecular Biology. 17: 582-9. PMID 20400947 DOI: 10.1038/Nsmb.1819  0.378
2010 Worrall LJ, Vuckovic M, Strynadka NC. Crystal structure of the C-terminal domain of the Salmonella type III secretion system export apparatus protein InvA. Protein Science : a Publication of the Protein Society. 19: 1091-6. PMID 20306492 DOI: 10.1002/pro.382  0.423
2009 Rao FV, Rich JR, Rakić B, Buddai S, Schwartz MF, Johnson K, Bowe C, Wakarchuk WW, Defrees S, Withers SG, Strynadka NC. Structural insight into mammalian sialyltransferases. Nature Structural & Molecular Biology. 16: 1186-8. PMID 19820709 DOI: 10.1038/Nsmb.1685  0.305
2009 Moraes TF, Yu RH, Strynadka NC, Schryvers AB. Insights into the bacterial transferrin receptor: the structure of transferrin-binding protein B from Actinobacillus pleuropneumoniae. Molecular Cell. 35: 523-33. PMID 19716795 DOI: 10.1016/J.Molcel.2009.06.029  0.674
2009 Lee HJ, Rakić B, Gilbert M, Wakarchuk WW, Withers SG, Strynadka NC. Structural and kinetic characterizations of the polysialic acid O-acetyltransferase OatWY from Neisseria meningitidis. The Journal of Biological Chemistry. 284: 24501-11. PMID 19525232 DOI: 10.1074/Jbc.M109.006049  0.301
2009 Spreter T, Yip CK, Sanowar S, André I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC. A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system. Nature Structural & Molecular Biology. 16: 468-76. PMID 19396170 DOI: 10.1038/Nsmb.1603  0.586
2009 Gretes M, Lim DC, de Castro L, Jensen SE, Kang SG, Lee KJ, Strynadka NC. Insights into positive and negative requirements for protein-protein interactions by crystallographic analysis of the beta-lactamase inhibitory proteins BLIP, BLIP-I, and BLP. Journal of Molecular Biology. 389: 289-305. PMID 19332077 DOI: 10.1016/j.jmb.2009.03.058  0.36
2009 Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR, Strynadka N, Eltis LD. Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis. Plos Pathogens. 5: e1000344. PMID 19300498 DOI: 10.1371/Journal.Ppat.1000344  0.37
2008 Okon M, Moraes TF, Lario PI, Creagh AL, Haynes CA, Strynadka NC, McIntosh LP. Structural characterization of the type-III pilot-secretin complex from Shigella flexneri. Structure (London, England : 1993). 16: 1544-54. PMID 18940609 DOI: 10.1016/J.Str.2008.08.006  0.708
2008 Wilke MS, Heller M, Creagh AL, Haynes CA, McIntosh LP, Poole K, Strynadka NC. The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR. Proceedings of the National Academy of Sciences of the United States of America. 105: 14832-7. PMID 18812515 DOI: 10.1073/Pnas.0805489105  0.366
2008 Lovering AL, De Castro L, Strynadka NC. Identification of dynamic structural motifs involved in peptidoglycan glycosyltransfer. Journal of Molecular Biology. 383: 167-77. PMID 18760285 DOI: 10.1016/J.Jmb.2008.08.020  0.365
2008 Lovering AL, Gretes M, Strynadka NC. Structural details of the glycosyltransferase step of peptidoglycan assembly. Current Opinion in Structural Biology. 18: 534-43. PMID 18721881 DOI: 10.1016/J.Sbi.2008.07.002  0.356
2008 Zarivach R, Deng W, Vuckovic M, Felise HB, Nguyen HV, Miller SI, Finlay BB, Strynadka NC. Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS. Nature. 453: 124-7. PMID 18451864 DOI: 10.1038/Nature06832  0.404
2008 Banerjee R, Gretes M, Basuino L, Strynadka N, Chambers HF. In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 52: 2089-96. PMID 18378703 DOI: 10.1128/Aac.01403-07  0.316
2008 Moraes TF, Spreter T, Strynadka NC. Piecing together the type III injectisome of bacterial pathogens. Current Opinion in Structural Biology. 18: 258-66. PMID 18258424 DOI: 10.1016/J.Sbi.2007.12.011  0.707
2007 Kim J, Thanabalasuriar A, Chaworth-Musters T, Fromme JC, Frey EA, Lario PI, Metalnikov P, Rizg K, Thomas NA, Lee SF, Hartland EL, Hardwidge PR, Pawson T, Strynadka NC, Finlay BB, et al. The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function. Cell Host & Microbe. 2: 160-71. PMID 18005731 DOI: 10.1016/J.Chom.2007.07.010  0.326
2007 Lovering AL, Strynadka NC. High-resolution structure of the major periplasmic domain from the cell shape-determining filament MreC. Journal of Molecular Biology. 372: 1034-44. PMID 17707860 DOI: 10.1016/J.Jmb.2007.07.022  0.439
2007 Chiu CP, Lairson LL, Gilbert M, Wakarchuk WW, Withers SG, Strynadka NC. Structural analysis of the alpha-2,3-sialyltransferase Cst-I from Campylobacter jejuni in apo and substrate-analogue bound forms. Biochemistry. 46: 7196-204. PMID 17518445 DOI: 10.1021/Bi602543D  0.308
2007 Lovering AL, de Castro LH, Lim D, Strynadka NC. Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis. Science (New York, N.Y.). 315: 1402-5. PMID 17347437 DOI: 10.1126/Science.1136611  0.38
2007 Caines ME, Vaughan MD, Tarling CA, Hancock SM, Warren RA, Withers SG, Strynadka NC. Structural and mechanistic analyses of endo-glycoceramidase II, a membrane-associated family 5 glycosidase in the Apo and GM3 ganglioside-bound forms. The Journal of Biological Chemistry. 282: 14300-8. PMID 17329247 DOI: 10.1074/Jbc.M611455200  0.367
2007 Zarivach R, Vuckovic M, Deng W, Finlay BB, Strynadka NC. Structural analysis of a prototypical ATPase from the type III secretion system. Nature Structural & Molecular Biology. 14: 131-7. PMID 17237797 DOI: 10.1038/nsmb1196  0.406
2007 Moraes TF, Bains M, Hancock RE, Strynadka NC. An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane. Nature Structural & Molecular Biology. 14: 85-7. PMID 17187075 DOI: 10.1038/Nsmb1189  0.676
2007 Reichmann D, Cohen M, Abramovich R, Dym O, Lim D, Strynadka NC, Schreiber G. Binding hot spots in the TEM1-BLIP interface in light of its modular architecture. Journal of Molecular Biology. 365: 663-79. PMID 17070843 DOI: 10.1016/J.Jmb.2006.09.076  0.305
2006 Knodler LA, Bertero M, Yip C, Strynadka NC, Steele-Mortimer O. Structure-based mutagenesis of SigE verifies the importance of hydrophobic and electrostatic residues in type III chaperone function. Molecular Microbiology. 62: 928-40. PMID 17038123 DOI: 10.1111/J.1365-2958.2006.05418.X  0.55
2006 Wang YA, Yu X, Yip C, Strynadka NC, Egelman EH. Structural polymorphism in bacterial EspA filaments revealed by cryo-EM and an improved approach to helical reconstruction. Structure (London, England : 1993). 14: 1189-96. PMID 16843900 DOI: 10.1016/J.Str.2006.05.018  0.511
2006 Lovering AL, De Castro L, Lim D, Strynadka NC. Structural analysis of an "open" form of PBP1B from Streptococcus pneumoniae. Protein Science : a Publication of the Protein Society. 15: 1701-9. PMID 16751607 DOI: 10.1110/Ps.062112106  0.377
2006 Yip CK, Strynadka NC. New structural insights into the bacterial type III secretion system. Trends in Biochemical Sciences. 31: 223-30. PMID 16537106 DOI: 10.1016/j.tibs.2006.02.005  0.604
2005 Thomas NA, Deng W, Puente JL, Frey EA, Yip CK, Strynadka NC, Finlay BB. CesT is a multi-effector chaperone and recruitment factor required for the efficient type III secretion of both LEE- and non-LEE-encoded effectors of enteropathogenic Escherichia coli. Molecular Microbiology. 57: 1762-79. PMID 16135239 DOI: 10.1111/j.1365-2958.2005.04802.x  0.569
2005 Yip CK, Kimbrough TG, Felise HB, Vuckovic M, Thomas NA, Pfuetzner RA, Frey EA, Finlay BB, Miller SI, Strynadka NC. Structural characterization of the molecular platform for type III secretion system assembly. Nature. 435: 702-7. PMID 15931226 DOI: 10.1038/Nature03554  0.614
2005 Lario PI, Pfuetzner RA, Frey EA, Creagh L, Haynes C, Maurelli AT, Strynadka NC. Structure and biochemical analysis of a secretin pilot protein. The Embo Journal. 24: 1111-21. PMID 15775974 DOI: 10.1038/Sj.Emboj.7600610  0.461
2005 Yip CK, Finlay BB, Strynadka NC. Structural characterization of a type III secretion system filament protein in complex with its chaperone. Nature Structural & Molecular Biology. 12: 75-81. PMID 15619638 DOI: 10.1038/nsmb879  0.622
2005 Bertero MG, Rothery RA, Boroumand N, Palak M, Blasco F, Ginet N, Weiner JH, Strynadka NC. Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A. The Journal of Biological Chemistry. 280: 14836-43. PMID 15615728 DOI: 10.1074/jbc.M410457200  0.343
2005 Gunawan J, Simard D, Gilbert M, Lovering AL, Wakarchuk WW, Tanner ME, Strynadka NC. Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol. The Journal of Biological Chemistry. 280: 3555-63. PMID 15516336 DOI: 10.1074/Jbc.M411942200  0.375
2004 Loschi L, Brokx SJ, Hills TL, Zhang G, Bertero MG, Lovering AL, Weiner JH, Strynadka NC. Structural and biochemical identification of a novel bacterial oxidoreductase. The Journal of Biological Chemistry. 279: 50391-400. PMID 15355966 DOI: 10.1074/Jbc.M408876200  0.366
2004 Wilke MS, Hills TL, Zhang HZ, Chambers HF, Strynadka NC. Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus. The Journal of Biological Chemistry. 279: 47278-87. PMID 15322076 DOI: 10.1074/Jbc.M407054200  0.331
2004 Schubert M, Edge RE, Lario P, Cook MA, Strynadka NC, Mackie GA, McIntosh LP. Structural characterization of the RNase E S1 domain and identification of its oligonucleotide-binding and dimerization interfaces. Journal of Molecular Biology. 341: 37-54. PMID 15312761 DOI: 10.1016/J.Jmb.2004.05.061  0.356
2004 Chiu CP, Watts AG, Lairson LL, Gilbert M, Lim D, Wakarchuk WW, Withers SG, Strynadka NC. Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog. Nature Structural & Molecular Biology. 11: 163-70. PMID 14730352 DOI: 10.1038/Nsmb720  0.372
2003 Bertero MG, Rothery RA, Palak M, Hou C, Lim D, Blasco F, Weiner JH, Strynadka NC. Insights into the respiratory electron transfer pathway from the structure of nitrate reductase A. Nature Structural Biology. 10: 681-7. PMID 12910261 DOI: 10.1038/nsb969  0.353
2002 Lim D, Poole K, Strynadka NC. Crystal structure of the MexR repressor of the mexRAB-oprM multidrug efflux operon of Pseudomonas aeruginosa. The Journal of Biological Chemistry. 277: 29253-9. PMID 12034710 DOI: 10.1074/jbc.M111381200  0.32
2002 Paetzel M, Dalbey RE, Strynadka NC. Crystal structure of a bacterial signal peptidase apoenzyme: implications for signal peptide binding and the Ser-Lys dyad mechanism. The Journal of Biological Chemistry. 277: 9512-9. PMID 11741964 DOI: 10.1074/Jbc.M110983200  0.34
2001 Luo Y, Samuel J, Mosimann SC, Lee JE, Tanner ME, Strynadka NC. The structure of L-ribulose-5-phosphate 4-epimerase: an aldolase-like platform for epimerization. Biochemistry. 40: 14763-71. PMID 11732895 DOI: 10.1021/Bi0112513  0.33
2001 Luo Y, Bertero MG, Frey EA, Pfuetzner RA, Wenk MR, Creagh L, Marcus SL, Lim D, Sicheri F, Kay C, Haynes C, Finlay BB, Strynadka NC. Structural and biochemical characterization of the type III secretion chaperones CesT and SigE. Nature Structural Biology. 8: 1031-6. PMID 11685226 DOI: 10.1038/Nsb717  0.384
2001 Persson K, Ly HD, Dieckelmann M, Wakarchuk WW, Withers SG, Strynadka NC. Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs. Nature Structural Biology. 8: 166-75. PMID 11175908 DOI: 10.1038/84168  0.308
2001 Lim D, Sanschagrin F, Passmore L, De Castro L, Levesque RC, Strynadka NC. Insights into the molecular basis for the carbenicillinase activity of PSE-4 beta-lactamase from crystallographic and kinetic studies. Biochemistry. 40: 395-402. PMID 11148033 DOI: 10.1021/Bi001653V  0.317
2001 Mosimann SC, Gilbert M, Dombroswki D, To R, Wakarchuk W, Strynadka NC. Structure of a sialic acid-activating synthetase, CMP-acylneuraminate synthetase in the presence and absence of CDP. The Journal of Biological Chemistry. 276: 8190-6. PMID 11113120 DOI: 10.1074/jbc.M007235200  0.352
2000 Campbell RE, Mosimann SC, Tanner ME, Strynadka NC. The structure of UDP-N-acetylglucosamine 2-epimerase reveals homology to phosphoglycosyl transferases. Biochemistry. 39: 14993-5001. PMID 11106477 DOI: 10.1021/Bi001627X  0.352
2000 Paetzel M, Danel F, de Castro L, Mosimann SC, Page MG, Strynadka NC. Crystal structure of the class D beta-lactamase OXA-10. Nature Structural Biology. 7: 918-25. PMID 11017203 DOI: 10.1038/79688  0.315
2000 Paetzel M, Dalbey RE, Strynadka NC. The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target. Pharmacology & Therapeutics. 87: 27-49. PMID 10924740 DOI: 10.1016/S0163-7258(00)00064-4  0.307
1999 Paetzel M, Strynadka NCJ. Common protein architecture and binding sites in proteases utilizing a Ser/Lys dyad mechanism Protein Science. 8: 2533-2536. PMID 10595561 DOI: 10.1110/Ps.8.11.2533  0.376
1998 Paetzel M, Dalbey RE, Strynadka NC. Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor. Nature. 396: 186-90. PMID 9823901 DOI: 10.1038/24196  0.377
1997 Strynadka NC, Cherney M, Sielecki AR, Li MX, Smillie LB, James MN. Structural details of a calcium-induced molecular switch: X-ray crystallographic analysis of the calcium-saturated N-terminal domain of troponin C at 1.75 A resolution. Journal of Molecular Biology. 273: 238-55. PMID 9367759 DOI: 10.1006/Jmbi.1997.1257  0.464
1997 Paetzel M, Strynadka NC, Tschantz WR, Casareno R, Bullinger PR, Dalbey RE. Use of site-directed chemical modification to study an essential lysine in Escherichia coli leader peptidase. The Journal of Biological Chemistry. 272: 9994-10003. PMID 9092541 DOI: 10.1074/Jbc.272.15.9994  0.303
1996 Strynadka NC, James MN. Lysozyme: a model enzyme in protein crystallography. Exs. 75: 185-222. PMID 8765301  0.584
1996 Strynadka NC, Jensen SE, Alzari PM, James MN. A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex. Nature Structural Biology. 3: 290-7. PMID 8605632 DOI: 10.1038/Nsb0396-290  0.484
1996 Strynadka NC, Eisenstein M, Katchalski-Katzir E, Shoichet BK, Kuntz ID, Abagyan R, Totrov M, Janin J, Cherfils J, Zimmerman F, Olson A, Duncan B, Rao M, Jackson R, Sternberg M, et al. Molecular docking programs successfully predict the binding of a beta-lactamase inhibitory protein to TEM-1 beta-lactamase. Nature Structural Biology. 3: 233-9. PMID 8605624 DOI: 10.1038/Nsb0396-233  0.49
1995 Paetzel M, Chernaia M, Strynadka N, Tschantz W, Cao G, Dalbey RE, James MN. Crystallization of a soluble, catalytically active form of Escherichia coli leader peptidase. Proteins. 23: 122-5. PMID 8539246 DOI: 10.1002/Prot.340230115  0.566
1994 Strynadka NC, Jensen SE, Johns K, Blanchard H, Page M, Matagne A, Frère JM, James MN. Structural and kinetic characterization of a beta-lactamase-inhibitor protein. Nature. 368: 657-60. PMID 8145854 DOI: 10.1038/368657A0  0.5
1994 Huang K, Strynadka NC, Bernard VD, Peanasky RJ, James MN. The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase. Structure (London, England : 1993). 2: 679-89. PMID 7922044  0.503
1992 Fraser ME, Strynadka NC, Bartlett PA, Hanson JE, James MN. Crystallographic analysis of transition-state mimics bound to penicillopepsin: phosphorus-containing peptide analogues. Biochemistry. 31: 5201-14. PMID 1606144 DOI: 10.2210/Pdb1Ppm/Pdb  0.424
1992 Strynadka NC, Adachi H, Jensen SE, Johns K, Sielecki A, Betzel C, Sutoh K, James MN. Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution. Nature. 359: 700-5. PMID 1436034 DOI: 10.1038/359700A0  0.511
1991 Brito RM, Putkey JA, Strynadka NC, James MN, Rosevear PR. Comparative NMR studies on cardiac troponin C and a mutant incapable of binding calcium at site II. Biochemistry. 30: 10236-45. PMID 1931952 DOI: 10.1021/Bi00106A023  0.517
1991 Strynadka NC, James MN. Lysozyme revisited: crystallographic evidence for distortion of an N-acetylmuramic acid residue bound in site D. Journal of Molecular Biology. 220: 401-24. PMID 1856865 DOI: 10.1016/0022-2836(91)90021-W  0.48
1991 McPhalen CA, Strynadka NC, James MN. Calcium-binding sites in proteins: a structural perspective. Advances in Protein Chemistry. 42: 77-144. PMID 1793008 DOI: 10.1016/S0065-3233(08)60535-5  0.465
1990 Strynadka NC, James MN. Model for the interaction of amphiphilic helices with troponin C and calmodulin. Proteins. 7: 234-48. PMID 2362945 DOI: 10.1002/Prot.340070305  0.524
1989 Trewhella J, Kevin Liddle W, Heidorn DB, Strynadka N. Calmodulin and troponin C structures studied by Fourier transform infrared spectroscopy: Effects of Ca2+ and Mg2+ binding Biochemistry. 28: 1294-1301. PMID 2713365 DOI: 10.1021/Bi00429A052  0.326
1989 Strynadka NC, James MN. Crystal structures of the helix-loop-helix calcium-binding proteins. Annual Review of Biochemistry. 58: 951-98. PMID 2673026 DOI: 10.1146/annurev.bi.58.070189.004511  0.513
1988 Strynadka NC, James MN. Two trifluoperazine-binding sites on calmodulin predicted from comparative molecular modeling with troponin-C. Proteins. 3: 1-17. PMID 3375233 DOI: 10.1002/Prot.340030102  0.535
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