Natalie Strynadka - Publications

Biochemistry and Molecular Biology University of British Columbia, Vancouver, Vancouver, BC, Canada 
structure-based design of novel, therapeutically useful antibiotics and inhibitors of antibiotic-resistance mechanisms

137 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 King AM, King DT, French S, Brouillette E, Asli A, Alexander JA, Vuckovic M, Maiti SN, Parr TR, Brown ED, Malouin F, Strynadka NC, Wright GD. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. Acs Chemical Biology. PMID 26731698 DOI: 10.1021/acschembio.5b00944  0.6
2015 Bergeron JR, Fernández L, Wasney GA, Vuckovic M, Reffuveille F, Hancock RE, Strynadka NC. The Structure of a T3SS Ruler Protein Suggests a Molecular Mechanism for Needle Length Sensing. The Journal of Biological Chemistry. PMID 26589798 DOI: 10.1074/jbc.M115.684423  0.6
2015 Burkinshaw BJ, Souza SA, Strynadka NC. Structural analysis of SepL, an enteropathogenic Escherichia coli type III secretion-system gatekeeper protein. Acta Crystallographica. Section F, Structural Biology Communications. 71: 1300-8. PMID 26457522 DOI: 10.1107/S2053230X15016064  0.6
2015 Farha MA, Czarny TL, Myers CL, Worrall LJ, French S, Conrady DG, Wang Y, Oldfield E, Strynadka NC, Brown ED. Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase. Proceedings of the National Academy of Sciences of the United States of America. 112: 11048-53. PMID 26283394 DOI: 10.1073/pnas.1511751112  0.6
2015 Ghavami A, Labbé G, Brem J, Goodfellow VJ, Marrone L, Tanner CA, King DT, Lam M, Strynadka NC, Pillai DR, Siemann S, Spencer J, Schofield CJ, Dmitrienko GI. Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates. Analytical Biochemistry. PMID 26142222 DOI: 10.1016/j.ab.2015.06.032  0.6
2015 Baier F, Chen J, Solomonson M, Strynadka NC, Tokuriki N. Distinct Metal Isoforms Underlie Promiscuous Activity Profiles of Metalloenzymes. Acs Chemical Biology. 10: 1684-93. PMID 25856271 DOI: 10.1021/acschembio.5b00068  0.6
2015 Solomonson M, Setiaputra D, Makepeace KA, Lameignere E, Petrotchenko EV, Conrady DG, Bergeron JR, Vuckovic M, DiMaio F, Borchers CH, Yip CK, Strynadka NC. Structure of EspB from the ESX-1 type VII secretion system and insights into its export mechanism. Structure (London, England : 1993). 23: 571-83. PMID 25684576 DOI: 10.1016/j.str.2015.01.002  0.6
2015 Burkinshaw BJ, Deng W, Lameignère E, Wasney GA, Zhu H, Worrall LJ, Finlay BB, Strynadka NC. Structural analysis of a specialized type III secretion system peptidoglycan-cleaving enzyme. The Journal of Biological Chemistry. 290: 10406-17. PMID 25678709 DOI: 10.1074/jbc.M115.639013  0.6
2015 Sobhanifar S, Worrall LJ, Gruninger RJ, Wasney GA, Blaukopf M, Baumann L, Lameignere E, Solomonson M, Brown ED, Withers SG, Strynadka NC. Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid α-glycosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 112: E576-85. PMID 25624472 DOI: 10.1073/pnas.1418084112  0.6
2015 Bergeron JR, Worrall LJ, De S, Sgourakis NG, Cheung AH, Lameignere E, Okon M, Wasney GA, Baker D, McIntosh LP, Strynadka NC. The modular structure of the inner-membrane ring component PrgK facilitates assembly of the type III secretion system basal body. Structure (London, England : 1993). 23: 161-72. PMID 25533490 DOI: 10.1016/j.str.2014.10.021  0.6
2015 Tsai CL, Burkinshaw BJ, Strynadka NC, Tainer JA. The Salmonella type III secretion system virulence effector forms a new hexameric chaperone assembly for export of effector/chaperone complexes. Journal of Bacteriology. 197: 672-5. PMID 25488302 DOI: 10.1128/JB.02524-14  0.6
2015 Volkers G, Worrall LJ, Kwan DH, Yu CC, Baumann L, Lameignere E, Wasney GA, Scott NE, Wakarchuk W, Foster LJ, Withers SG, Strynadka NCJ. Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation Nature Structural and Molecular Biology. DOI: 10.1038/nsmb.3060  0.6
2014 Penfield JS, Worrall LJ, Strynadka NC, Eltis LD. Substrate specificities and conformational flexibility of 3-ketosteroid 9α-hydroxylases. The Journal of Biological Chemistry. 289: 25523-36. PMID 25049233 DOI: 10.1074/jbc.M114.575886  0.6
2014 King AM, Reid-Yu SA, Wang W, King DT, De Pascale G, Strynadka NC, Walsh TR, Coombes BK, Wright GD. Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance. Nature. 510: 503-6. PMID 24965651 DOI: 10.1038/nature13445  0.6
2014 King DT, Lameignere E, Strynadka NC. Structural insights into the lipoprotein outer membrane regulator of penicillin-binding protein 1B. The Journal of Biological Chemistry. 289: 19245-53. PMID 24808177 DOI: 10.1074/jbc.M114.565879  0.6
2014 Burkinshaw BJ, Strynadka NC. Assembly and structure of the T3SS. Biochimica Et Biophysica Acta. 1843: 1649-63. PMID 24512838 DOI: 10.1016/j.bbamcr.2014.01.035  0.6
2014 Wat JM, Foley JH, Krisinger MJ, Ocariza LM, Lei V, Wasney GA, Lameignere E, Strynadka NC, Smith SA, Morrissey JH, Conway EM. Polyphosphate suppresses complement via the terminal pathway. Blood. 123: 768-76. PMID 24335501 DOI: 10.1182/blood-2013-07-515726  0.6
2013 Sobhanifar S, King DT, Strynadka NC. Fortifying the wall: synthesis, regulation and degradation of bacterial peptidoglycan. Current Opinion in Structural Biology. 23: 695-703. PMID 23910891 DOI: 10.1016/  0.6
2013 King DT, Strynadka NC. Targeting metallo-β-lactamase enzymes in antibiotic resistance. Future Medicinal Chemistry. 5: 1243-63. PMID 23859206 DOI: 10.4155/fmc.13.55  0.6
2013 Bergeron JR, Worrall LJ, Sgourakis NG, DiMaio F, Pfuetzner RA, Felise HB, Vuckovic M, Yu AC, Miller SI, Baker D, Strynadka NC. A refined model of the prototypical Salmonella SPI-1 T3SS basal body reveals the molecular basis for its assembly. Plos Pathogens. 9: e1003307. PMID 23633951 DOI: 10.1371/journal.ppat.1003307  0.6
2013 Solomonson M, Huesgen PF, Wasney GA, Watanabe N, Gruninger RJ, Prehna G, Overall CM, Strynadka NC. Structure of the mycosin-1 protease from the mycobacterial ESX-1 protein type VII secretion system. The Journal of Biological Chemistry. 288: 17782-90. PMID 23620593 DOI: 10.1074/jbc.M113.462036  0.6
2013 Ludwiczek ML, D'Angelo I, Yalloway GN, Brockerman JA, Okon M, Nielsen JE, Strynadka NC, Withers SG, McIntosh LP. Strategies for modulating the pH-dependent activity of a family 11 glycoside hydrolase. Biochemistry. 52: 3138-56. PMID 23578322 DOI: 10.1021/bi400034m  0.6
2013 Sal-Man N, Setiaputra D, Scholz R, Deng W, Yu AC, Strynadka NC, Finlay BB. EscE and EscG are cochaperones for the type III needle protein EscF of enteropathogenic Escherichia coli. Journal of Bacteriology. 195: 2481-9. PMID 23524615 DOI: 10.1128/JB.00118-13  0.6
2013 Rakic B, Rao FV, Freimann K, Wakarchuk W, Strynadka NC, Withers SG. Structure-based mutagenic analysis of mechanism and substrate specificity in mammalian glycosyltransferases: porcine ST3Gal-I. Glycobiology. 23: 536-45. PMID 23300007 DOI: 10.1093/glycob/cwt001  0.6
2013 Worrall LJ, Bergeron JRC, Strynadka NCJ. Type 3 secretion systems Escherichia Coli: Pathotypes and Principles of Pathogenesis: Second Edition. 417-450. DOI: 10.1016/B978-0-12-397048-0.00014-0  0.6
2013 Sobhanifar S, Prehna G, Strynadka NCJ. BlaR1 and MecR1 Gene Products of Staphylococcus aureus Handbook of Proteolytic Enzymes. 1: 1237-1242. DOI: 10.1016/B978-0-12-382219-2.00278-7  0.6
2012 Kumar NS, Amandoron EA, Cherkasov A, Finlay BB, Gong H, Jackson L, Kaur S, Lian T, Moreau A, Labrière C, Reiner NE, See RH, Strynadka NC, Thorson L, Wong EW, et al. Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents. Bioorganic & Medicinal Chemistry. 20: 7069-82. PMID 23141418 DOI: 10.1016/j.bmc.2012.10.002  0.6
2012 Lovering AL, Gretes MC, Safadi SS, Danel F, de Castro L, Page MG, Strynadka NC. Structural insights into the anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of ceftobiprole. The Journal of Biological Chemistry. 287: 32096-102. PMID 22815485 DOI: 10.1074/jbc.M112.355644  0.6
2012 Prehna G, Li Y, Stoynov N, Okon M, Vuckovic M, McIntosh LP, Foster LJ, Finlay BB, Strynadka NC. The zinc regulated antivirulence pathway of Salmonella is a multiprotein immunoglobulin adhesion system. The Journal of Biological Chemistry. 287: 32324-37. PMID 22810234 DOI: 10.1074/jbc.M112.357210  0.6
2012 King DT, Worrall LJ, Gruninger R, Strynadka NC. New Delhi metallo-β-lactamase: structural insights into β-lactam recognition and inhibition. Journal of the American Chemical Society. 134: 11362-5. PMID 22713171 DOI: 10.1021/ja303579d  0.6
2012 Lovering AL, Safadi SS, Strynadka NC. Structural perspective of peptidoglycan biosynthesis and assembly. Annual Review of Biochemistry. 81: 451-78. PMID 22663080 DOI: 10.1146/annurev-biochem-061809-112742  0.6
2012 Prehna G, Zhang G, Gong X, Duszyk M, Okon M, McIntosh LP, Weiner JH, Strynadka NC. A protein export pathway involving Escherichia coli porins. Structure (London, England : 1993). 20: 1154-66. PMID 22658749 DOI: 10.1016/j.str.2012.04.014  0.6
2012 Schur MJ, Lameignere E, Strynadka NC, Wakarchuk WW. Characterization of α2,3- and α2,6-sialyltransferases from Helicobacter acinonychis. Glycobiology. 22: 997-1006. PMID 22504533 DOI: 10.1093/glycob/cws071  0.6
2012 Yu AC, Worrall LJ, Strynadka NC. Structural insight into the bacterial mucinase StcE essential to adhesion and immune evasion during enterohemorrhagic E. coli infection. Structure (London, England : 1993). 20: 707-17. PMID 22483117 DOI: 10.1016/j.str.2012.02.015  0.6
2012 Thanabalasuriar A, Bergeron J, Gillingham A, Mimee M, Thomassin JL, Strynadka N, Kim J, Gruenheid S. Sec24 interaction is essential for localization and virulence-associated function of the bacterial effector protein NleA. Cellular Microbiology. 14: 1206-18. PMID 22432415 DOI: 10.1111/j.1462-5822.2012.01789.x  0.6
2012 Burkinshaw BJ, Prehna G, Worrall LJ, Strynadka NC. Structure of Salmonella effector protein SopB N-terminal domain in complex with host Rho GTPase Cdc42. The Journal of Biological Chemistry. 287: 13348-55. PMID 22362774 DOI: 10.1074/jbc.M111.331330  0.6
2012 Axerio-Cilies P, See RH, Zoraghi R, Worral L, Lian T, Stoynov N, Jiang J, Kaur S, Jackson L, Gong H, Swayze R, Amandoron E, Kumar NS, Moreau A, Hsing M, ... Strynadka NC, et al. Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase. Acs Chemical Biology. 7: 350-9. PMID 22066782 DOI: 10.1021/cb2003576  0.6
2011 Zoraghi R, Worrall L, See RH, Strangman W, Popplewell WL, Gong H, Samaai T, Swayze RD, Kaur S, Vuckovic M, Finlay BB, Brunham RC, McMaster WR, Davies-Coleman MT, Strynadka NC, et al. Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities. The Journal of Biological Chemistry. 286: 44716-25. PMID 22030393 DOI: 10.1074/jbc.M111.289033  0.6
2011 Capyk JK, Casabon I, Gruninger R, Strynadka NC, Eltis LD. Activity of 3-ketosteroid 9α-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis. The Journal of Biological Chemistry. 286: 40717-24. PMID 21987574 DOI: 10.1074/jbc.M111.289975  0.6
2011 Lin LY, Rakic B, Chiu CP, Lameignere E, Wakarchuk WW, Withers SG, Strynadka NC. Structure and mechanism of the lipooligosaccharide sialyltransferase from Neisseria meningitidis. The Journal of Biological Chemistry. 286: 37237-48. PMID 21880735 DOI: 10.1074/jbc.M111.249920  0.6
2011 Lee HJ, Lairson LL, Rich JR, Lameignere E, Wakarchuk WW, Withers SG, Strynadka NC. Structural and kinetic analysis of substrate binding to the sialyltransferase Cst-II from Campylobacter jejuni. The Journal of Biological Chemistry. 286: 35922-32. PMID 21832050 DOI: 10.1074/jbc.M111.261172  0.6
2011 King D, Strynadka N. Crystal structure of New Delhi metallo-β-lactamase reveals molecular basis for antibiotic resistance. Protein Science : a Publication of the Protein Society. 20: 1484-91. PMID 21774017 DOI: 10.1002/pro.697  0.6
2011 Zoraghi R, See RH, Axerio-Cilies P, Kumar NS, Gong H, Moreau A, Hsing M, Kaur S, Swayze RD, Worrall L, Amandoron E, Lian T, Jackson L, Jiang J, Thorson L, ... ... Strynadka NC, et al. Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target. Antimicrobial Agents and Chemotherapy. 55: 2042-53. PMID 21357306 DOI: 10.1128/AAC.01250-10  0.6
2011 Worrall LJ, Lameignere E, Strynadka NC. Structural overview of the bacterial injectisome. Current Opinion in Microbiology. 14: 3-8. PMID 21112241 DOI: 10.1016/j.mib.2010.10.009  0.6
2010 Babu M, Greenblatt JF, Emili A, Strynadka NC, Reithmeier RA, Moraes TF. Structure of a SLC26 anion transporter STAS domain in complex with acyl carrier protein: implications for E. coli YchM in fatty acid metabolism. Structure (London, England : 1993). 18: 1450-62. PMID 21070944 DOI: 10.1016/j.str.2010.08.015  0.6
2010 Sanowar S, Singh P, Pfuetzner RA, André I, Zheng H, Spreter T, Strynadka NC, Gonen T, Baker D, Goodlett DR, Miller SI. Interactions of the transmembrane polymeric rings of the Salmonella enterica serovar Typhimurium type III secretion system. Mbio. 1. PMID 20824104 DOI: 10.1128/mBio.00158-10  0.6
2010 Dresen C, Lin LY, D'Angelo I, Tocheva EI, Strynadka N, Eltis LD. A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism. The Journal of Biological Chemistry. 285: 22264-75. PMID 20448045 DOI: 10.1074/jbc.M109.099028  0.6
2010 Lovering AL, Lin LY, Sewell EW, Spreter T, Brown ED, Strynadka NC. Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis. Nature Structural & Molecular Biology. 17: 582-9. PMID 20400947 DOI: 10.1038/nsmb.1819  0.6
2010 Worrall LJ, Vuckovic M, Strynadka NC. Crystal structure of the C-terminal domain of the Salmonella type III secretion system export apparatus protein InvA. Protein Science : a Publication of the Protein Society. 19: 1091-6. PMID 20306492 DOI: 10.1002/pro.382  0.6
2010 Reitinger S, Yu Y, Wicki J, Ludwiczek M, D'Angelo I, Baturin S, Okon M, Strynadka NC, Lutz S, Withers SG, McIntosh LP. Circular permutation of Bacillus circulans xylanase: a kinetic and structural study. Biochemistry. 49: 2464-74. PMID 20163191 DOI: 10.1021/bi100036f  0.6
2010 Johnson JW, Gretes M, Goodfellow VJ, Marrone L, Heynen ML, Strynadka NC, Dmitrienko GI. Cyclobutanone analogues of beta-lactams revisited: insights into conformational requirements for inhibition of serine- and metallo-beta-lactamases. Journal of the American Chemical Society. 132: 2558-60. PMID 20141132 DOI: 10.1021/ja9086374  0.6
2010 Rothery RA, Bertero MG, Spreter T, Bouromand N, Strynadka NC, Weiner JH. Protein crystallography reveals a role for the FS0 cluster of Escherichia coli nitrate reductase A (NarGHI) in enzyme maturation. The Journal of Biological Chemistry. 285: 8801-7. PMID 20053990 DOI: 10.1074/jbc.M109.066027  0.6
2009 Chan PH, Lairson LL, Lee HJ, Wakarchuk WW, Strynadka NC, Withers SG, McIntosh LP. NMR spectroscopic characterization of the sialyltransferase CstII from Campylobacter jejuni: histidine 188 is the general base. Biochemistry. 48: 11220-30. PMID 19824695 DOI: 10.1021/bi901606n  0.6
2009 Rao FV, Rich JR, Rakić B, Buddai S, Schwartz MF, Johnson K, Bowe C, Wakarchuk WW, Defrees S, Withers SG, Strynadka NC. Structural insight into mammalian sialyltransferases. Nature Structural & Molecular Biology. 16: 1186-8. PMID 19820709 DOI: 10.1038/nsmb.1685  0.6
2009 Liu F, Lee HJ, Strynadka NC, Tanner ME. Inhibition of Neisseria meningitidis sialic acid synthase by a tetrahedral intermediate analogue. Biochemistry. 48: 9194-201. PMID 19719325 DOI: 10.1021/bi9012758  0.6
2009 Moraes TF, Yu RH, Strynadka NC, Schryvers AB. Insights into the bacterial transferrin receptor: the structure of transferrin-binding protein B from Actinobacillus pleuropneumoniae. Molecular Cell. 35: 523-33. PMID 19716795 DOI: 10.1016/j.molcel.2009.06.029  0.6
2009 Hancock SM, Rich JR, Caines ME, Strynadka NC, Withers SG. Designer enzymes for glycosphingolipid synthesis by directed evolution. Nature Chemical Biology. 5: 508-14. PMID 19525967 DOI: 10.1038/nchembio.191  0.6
2009 Lee HJ, Rakić B, Gilbert M, Wakarchuk WW, Withers SG, Strynadka NC. Structural and kinetic characterizations of the polysialic acid O-acetyltransferase OatWY from Neisseria meningitidis. The Journal of Biological Chemistry. 284: 24501-11. PMID 19525232 DOI: 10.1074/jbc.M109.006049  0.6
2009 Spreter T, Yip CK, Sanowar S, André I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC. A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system. Nature Structural & Molecular Biology. 16: 468-76. PMID 19396170 DOI: 10.1038/nsmb.1603  0.6
2009 Gretes M, Lim DC, de Castro L, Jensen SE, Kang SG, Lee KJ, Strynadka NC. Insights into positive and negative requirements for protein-protein interactions by crystallographic analysis of the beta-lactamase inhibitory proteins BLIP, BLIP-I, and BLP. Journal of Molecular Biology. 389: 289-305. PMID 19332077 DOI: 10.1016/j.jmb.2009.03.058  0.6
2009 Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR, Strynadka N, Eltis LD. Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis. Plos Pathogens. 5: e1000344. PMID 19300498 DOI: 10.1371/journal.ppat.1000344  0.6
2009 Capyk JK, D'Angelo I, Strynadka NC, Eltis LD. Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis. The Journal of Biological Chemistry. 284: 9937-46. PMID 19234303 DOI: 10.1074/jbc.M900719200  0.6
2008 Okon M, Moraes TF, Lario PI, Creagh AL, Haynes CA, Strynadka NC, McIntosh LP. Structural characterization of the type-III pilot-secretin complex from Shigella flexneri. Structure (London, England : 1993). 16: 1544-54. PMID 18940609 DOI: 10.1016/j.str.2008.08.006  0.6
2008 van Aalten DM, Strynadka NC. Putting glycobiology on a structural footing. Current Opinion in Structural Biology. 18: 525-6. PMID 18822377 DOI: 10.1016/  0.6
2008 Wilke MS, Heller M, Creagh AL, Haynes CA, McIntosh LP, Poole K, Strynadka NC. The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR. Proceedings of the National Academy of Sciences of the United States of America. 105: 14832-7. PMID 18812515 DOI: 10.1073/pnas.0805489105  0.6
2008 Caines ME, Zhu H, Vuckovic M, Willis LM, Withers SG, Wakarchuk WW, Strynadka NC. The structural basis for T-antigen hydrolysis by Streptococcus pneumoniae: a target for structure-based vaccine design. The Journal of Biological Chemistry. 283: 31279-83. PMID 18784084 DOI: 10.1074/jbc.C800150200  0.6
2008 Lovering AL, De Castro L, Strynadka NC. Identification of dynamic structural motifs involved in peptidoglycan glycosyltransfer. Journal of Molecular Biology. 383: 167-77. PMID 18760285 DOI: 10.1016/j.jmb.2008.08.020  0.6
2008 Lovering AL, Gretes M, Strynadka NC. Structural details of the glycosyltransferase step of peptidoglycan assembly. Current Opinion in Structural Biology. 18: 534-43. PMID 18721881 DOI: 10.1016/  0.6
2008 Zarivach R, Deng W, Vuckovic M, Felise HB, Nguyen HV, Miller SI, Finlay BB, Strynadka NC. Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS. Nature. 453: 124-7. PMID 18451864 DOI: 10.1038/nature06832  0.6
2008 Banerjee R, Gretes M, Basuino L, Strynadka N, Chambers HF. In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 52: 2089-96. PMID 18378703 DOI: 10.1128/AAC.01403-07  0.6
2008 Moraes TF, Spreter T, Strynadka NC. Piecing together the type III injectisome of bacterial pathogens. Current Opinion in Structural Biology. 18: 258-66. PMID 18258424 DOI: 10.1016/  0.6
2007 Kim J, Thanabalasuriar A, Chaworth-Musters T, Fromme JC, Frey EA, Lario PI, Metalnikov P, Rizg K, Thomas NA, Lee SF, Hartland EL, Hardwidge PR, Pawson T, Strynadka NC, Finlay BB, et al. The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function. Cell Host & Microbe. 2: 160-71. PMID 18005731 DOI: 10.1016/j.chom.2007.07.010  0.6
2007 Lovering AL, Strynadka NC. High-resolution structure of the major periplasmic domain from the cell shape-determining filament MreC. Journal of Molecular Biology. 372: 1034-44. PMID 17707860 DOI: 10.1016/j.jmb.2007.07.022  0.6
2007 Daigle DM, Cao L, Fraud S, Wilke MS, Pacey A, Klinoski R, Strynadka NC, Dean CR, Poole K. Protein modulator of multidrug efflux gene expression in Pseudomonas aeruginosa. Journal of Bacteriology. 189: 5441-51. PMID 17545281 DOI: 10.1128/JB.00543-07  0.6
2007 Chiu CP, Lairson LL, Gilbert M, Wakarchuk WW, Withers SG, Strynadka NC. Structural analysis of the alpha-2,3-sialyltransferase Cst-I from Campylobacter jejuni in apo and substrate-analogue bound forms. Biochemistry. 46: 7196-204. PMID 17518445 DOI: 10.1021/bi602543d  0.6
2007 Caines ME, Hancock SM, Tarling CA, Wrodnigg TM, Stick RV, Stütz AE, Vasella A, Withers SG, Strynadka NC. The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system. Angewandte Chemie (International Ed. in English). 46: 4474-6. PMID 17487923 DOI: 10.1002/anie.200700268  0.6
2007 Lovering AL, de Castro LH, Lim D, Strynadka NC. Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis. Science (New York, N.Y.). 315: 1402-5. PMID 17347437 DOI: 10.1126/science.1136611  0.6
2007 Caines ME, Vaughan MD, Tarling CA, Hancock SM, Warren RA, Withers SG, Strynadka NC. Structural and mechanistic analyses of endo-glycoceramidase II, a membrane-associated family 5 glycosidase in the Apo and GM3 ganglioside-bound forms. The Journal of Biological Chemistry. 282: 14300-8. PMID 17329247 DOI: 10.1074/jbc.M611455200  0.6
2007 Zarivach R, Vuckovic M, Deng W, Finlay BB, Strynadka NC. Structural analysis of a prototypical ATPase from the type III secretion system. Nature Structural & Molecular Biology. 14: 131-7. PMID 17237797 DOI: 10.1038/nsmb1196  0.6
2007 Moraes TF, Bains M, Hancock RE, Strynadka NC. An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane. Nature Structural & Molecular Biology. 14: 85-7. PMID 17187075 DOI: 10.1038/nsmb1189  0.6
2007 Reichmann D, Cohen M, Abramovich R, Dym O, Lim D, Strynadka NC, Schreiber G. Binding hot spots in the TEM1-BLIP interface in light of its modular architecture. Journal of Molecular Biology. 365: 663-79. PMID 17070843 DOI: 10.1016/j.jmb.2006.09.076  0.6
2006 Knodler LA, Bertero M, Yip C, Strynadka NC, Steele-Mortimer O. Structure-based mutagenesis of SigE verifies the importance of hydrophobic and electrostatic residues in type III chaperone function. Molecular Microbiology. 62: 928-40. PMID 17038123 DOI: 10.1111/j.1365-2958.2006.05418.x  0.6
2006 Aharoni A, Thieme K, Chiu CP, Buchini S, Lairson LL, Chen H, Strynadka NC, Wakarchuk WW, Withers SG. High-throughput screening methodology for the directed evolution of glycosyltransferases. Nature Methods. 3: 609-14. PMID 16862135 DOI: 10.1038/nmeth899  0.6
2006 Wang YA, Yu X, Yip C, Strynadka NC, Egelman EH. Structural polymorphism in bacterial EspA filaments revealed by cryo-EM and an improved approach to helical reconstruction. Structure (London, England : 1993). 14: 1189-96. PMID 16843900 DOI: 10.1016/j.str.2006.05.018  0.6
2006 Lovering AL, De Castro L, Lim D, Strynadka NC. Structural analysis of an "open" form of PBP1B from Streptococcus pneumoniae. Protein Science : a Publication of the Protein Society. 15: 1701-9. PMID 16751607 DOI: 10.1110/ps.062112106  0.6
2006 Yip CK, Strynadka NC. New structural insights into the bacterial type III secretion system. Trends in Biochemical Sciences. 31: 223-30. PMID 16537106 DOI: 10.1016/j.tibs.2006.02.005  0.6
2006 Kim YW, Lovering AL, Chen H, Kantner T, McIntosh LP, Strynadka NC, Withers SG. Expanding the thioglycoligase strategy to the synthesis of alpha-linked thioglycosides allows structural investigation of the parent enzyme/substrate complex. Journal of the American Chemical Society. 128: 2202-3. PMID 16478160 DOI: 10.1021/ja057904a  0.6
2005 Thomas NA, Deng W, Puente JL, Frey EA, Yip CK, Strynadka NC, Finlay BB. CesT is a multi-effector chaperone and recruitment factor required for the efficient type III secretion of both LEE- and non-LEE-encoded effectors of enteropathogenic Escherichia coli. Molecular Microbiology. 57: 1762-79. PMID 16135239 DOI: 10.1111/j.1365-2958.2005.04802.x  0.6
2005 Wilke MS, Lovering AL, Strynadka NC. Beta-lactam antibiotic resistance: a current structural perspective. Current Opinion in Microbiology. 8: 525-33. PMID 16129657 DOI: 10.1016/j.mib.2005.08.016  0.6
2005 Yip CK, Kimbrough TG, Felise HB, Vuckovic M, Thomas NA, Pfuetzner RA, Frey EA, Finlay BB, Miller SI, Strynadka NC. Structural characterization of the molecular platform for type III secretion system assembly. Nature. 435: 702-7. PMID 15931226 DOI: 10.1038/nature03554  0.6
2005 Okon M, Pfuetzner RA, Vuckovic M, Little JW, Strynadka NC, McIntosh LP. Backbone chemical shift assignments of the LexA catalytic domain in its active conformation. Journal of Biomolecular Nmr. 31: 371-2. PMID 15929009 DOI: 10.1007/s10858-005-0944-8  0.6
2005 Cheng VW, Rothery RA, Bertero MG, Strynadka NC, Weiner JH. Investigation of the environment surrounding iron-sulfur cluster 4 of Escherichia coli dimethylsulfoxide reductase. Biochemistry. 44: 8068-77. PMID 15924426 DOI: 10.1021/bi050362p  0.6
2005 Lario PI, Pfuetzner RA, Frey EA, Creagh L, Haynes C, Maurelli AT, Strynadka NC. Structure and biochemical analysis of a secretin pilot protein. The Embo Journal. 24: 1111-21. PMID 15775974 DOI: 10.1038/sj.emboj.7600610  0.6
2005 Yip CK, Finlay BB, Strynadka NC. Structural characterization of a type III secretion system filament protein in complex with its chaperone. Nature Structural & Molecular Biology. 12: 75-81. PMID 15619638 DOI: 10.1038/nsmb879  0.6
2005 Bertero MG, Rothery RA, Boroumand N, Palak M, Blasco F, Ginet N, Weiner JH, Strynadka NC. Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A. The Journal of Biological Chemistry. 280: 14836-43. PMID 15615728 DOI: 10.1074/jbc.M410457200  0.6
2005 Gunawan J, Simard D, Gilbert M, Lovering AL, Wakarchuk WW, Tanner ME, Strynadka NC. Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol. The Journal of Biological Chemistry. 280: 3555-63. PMID 15516336 DOI: 10.1074/jbc.M411942200  0.6
2005 Lovering AL, Lee SS, Kim YW, Withers SG, Strynadka NC. Mechanistic and structural analysis of a family 31 alpha-glycosidase and its glycosyl-enzyme intermediate. The Journal of Biological Chemistry. 280: 2105-15. PMID 15501829 DOI: 10.1074/jbc.M410468200  0.6
2004 Loschi L, Brokx SJ, Hills TL, Zhang G, Bertero MG, Lovering AL, Weiner JH, Strynadka NC. Structural and biochemical identification of a novel bacterial oxidoreductase. The Journal of Biological Chemistry. 279: 50391-400. PMID 15355966 DOI: 10.1074/jbc.M408876200  0.6
2004 Schubert M, Edge RE, Lario P, Cook MA, Strynadka NC, Mackie GA, McIntosh LP. Structural characterization of the RNase E S1 domain and identification of its oligonucleotide-binding and dimerization interfaces. Journal of Molecular Biology. 341: 37-54. PMID 15312761 DOI: 10.1016/j.jmb.2004.05.061  0.6
2004 Lairson LL, Chiu CP, Ly HD, He S, Wakarchuk WW, Strynadka NC, Withers SG. Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue. The Journal of Biological Chemistry. 279: 28339-44. PMID 15075344 DOI: 10.1074/jbc.M400451200  0.6
2004 Chiu CP, Watts AG, Lairson LL, Gilbert M, Lim D, Wakarchuk WW, Withers SG, Strynadka NC. Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog. Nature Structural & Molecular Biology. 11: 163-70. PMID 14730352 DOI: 10.1038/nsmb720  0.6
2004 Strynadka NC, Hol WGJ. Proteins: The dazzling complexity and flexibility of proteins Current Opinion in Structural Biology. 14: 687-689. DOI: 10.1016/  0.6
2002 Paetzel M, Karla A, Strynadka NC, Dalbey RE. Signal peptidases. Chemical Reviews. 102: 4549-80. PMID 12475201 DOI: 10.1021/cr010166y  0.6
2002 Paetzel M, Dalbey RE, Strynadka NC. Crystal structure of a bacterial signal peptidase apoenzyme: implications for signal peptide binding and the Ser-Lys dyad mechanism. The Journal of Biological Chemistry. 277: 9512-9. PMID 11741964 DOI: 10.1074/jbc.M110983200  0.6
2001 Samuel J, Luo Y, Morgan PM, Strynadka NC, Tanner ME. Catalysis and binding in L-ribulose-5-phosphate 4-epimerase: a comparison with L-fuculose-1-phosphate aldolase. Biochemistry. 40: 14772-80. PMID 11732896 DOI: 10.1021/bi011252v  0.6
2001 Luo Y, Samuel J, Mosimann SC, Lee JE, Tanner ME, Strynadka NC. The structure of L-ribulose-5-phosphate 4-epimerase: an aldolase-like platform for epimerization. Biochemistry. 40: 14763-71. PMID 11732895 DOI: 10.1021/bi0112513  0.6
2001 Luo Y, Bertero MG, Frey EA, Pfuetzner RA, Wenk MR, Creagh L, Marcus SL, Lim D, Sicheri F, Kay C, Haynes C, Finlay BB, Strynadka NC. Structural and biochemical characterization of the type III secretion chaperones CesT and SigE. Nature Structural Biology. 8: 1031-6. PMID 11685226 DOI: 10.1038/nsb717  0.6
2001 Luo Y, Pfuetzner RA, Mosimann S, Paetzel M, Frey EA, Cherney M, Kim B, Little JW, Strynadka NC. Crystal structure of LexA: a conformational switch for regulation of self-cleavage. Cell. 106: 585-94. PMID 11551506 DOI: 10.1016/S0092-8674(01)00479-2  0.6
2001 White AP, Collinson SK, Banser PA, Gibson DL, Paetzel M, Strynadka NC, Kay WW. Structure and characterization of AgfB from Salmonella enteritidis thin aggregative fimbriae. Journal of Molecular Biology. 311: 735-49. PMID 11518527 DOI: 10.1006/jmbi.2001.4876  0.6
2001 Danel F, Paetzel M, Strynadka NC, Page MG. Effect of divalent metal cations on the dimerization of OXA-10 and -14 class D beta-lactamases from Pseudomonas aeruginosa. Biochemistry. 40: 9412-20. PMID 11478911 DOI: 10.1021/bi0025969  0.6
2001 Lim D, Sanschagrin F, Passmore L, De Castro L, Levesque RC, Strynadka NC. Insights into the molecular basis for the carbenicillinase activity of PSE-4 beta-lactamase from crystallographic and kinetic studies. Biochemistry. 40: 395-402. PMID 11148033 DOI: 10.1021/bi001653v  0.6
2000 Campbell RE, Mosimann SC, Tanner ME, Strynadka NC. The structure of UDP-N-acetylglucosamine 2-epimerase reveals homology to phosphoglycosyl transferases. Biochemistry. 39: 14993-5001. PMID 11106477 DOI: 10.1021/bi001627x  0.6
2000 Paetzel M, Danel F, de Castro L, Mosimann SC, Page MG, Strynadka NC. Crystal structure of the class D beta-lactamase OXA-10. Nature Structural Biology. 7: 918-25. PMID 11017203 DOI: 10.1038/79688  0.6
2000 Paetzel M, Dalbey RE, Strynadka NC. The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target. Pharmacology & Therapeutics. 87: 27-49. PMID 10924740 DOI: 10.1016/S0163-7258(00)00064-4  0.6
2000 Carlos JL, Klenotic PA, Paetzel M, Strynadka NC, Dalbey RE. Mutational evidence of transition state stabilization by serine 88 in Escherichia coli type I signal peptidase. Biochemistry. 39: 7276-83. PMID 10852727 DOI: 10.1021/bi000301l  0.6
2000 Ness S, Martin R, Kindler AM, Paetzel M, Gold M, Jensen SE, Jones JB, Strynadka NC. Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,). Biochemistry. 39: 5312-21. PMID 10820001 DOI: 10.1021/bi992505b  0.6
2000 Klenotic PA, Carlos JL, Samuelson JC, Schuenemann TA, Tschantz WR, Paetzel M, Strynadka NC, Dalbey RE. The role of the conserved box E residues in the active site of the Escherichia coli type I signal peptidase. The Journal of Biological Chemistry. 275: 6490-8. PMID 10692453 DOI: 10.1074/jbc.275.9.6490  0.6
1999 Paetzel M, Strynadka NCJ. Common protein architecture and binding sites in proteases utilizing a Ser/Lys dyad mechanism Protein Science. 8: 2533-2536. PMID 10595561 DOI: 10.1110/ps.8.11.2533  0.6
1998 Paetzel M, Dalbey RE, Strynadka NC. Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor. Nature. 396: 186-90. PMID 9823901 DOI: 10.1038/24196  0.6
1997 Strynadka NC, Cherney M, Sielecki AR, Li MX, Smillie LB, James MN. Structural details of a calcium-induced molecular switch: X-ray crystallographic analysis of the calcium-saturated N-terminal domain of troponin C at 1.75 A resolution. Journal of Molecular Biology. 273: 238-55. PMID 9367759 DOI: 10.1006/jmbi.1997.1257  1
1997 Paetzel M, Strynadka NC, Tschantz WR, Casareno R, Bullinger PR, Dalbey RE. Use of site-directed chemical modification to study an essential lysine in Escherichia coli leader peptidase. The Journal of Biological Chemistry. 272: 9994-10003. PMID 9092541 DOI: 10.1074/jbc.272.15.9994  0.6
1996 Strynadka NC, James MN. Lysozyme: a model enzyme in protein crystallography. Exs. 75: 185-222. PMID 8765301  1
1996 Strynadka NC, Martin R, Jensen SE, Gold M, Jones JB. Structure-based design of a potent transition state analogue for TEM-1 beta-lactamase. Nature Structural Biology. 3: 688-95. PMID 8756327 DOI: 10.1038/nsb0896-688  0.36
1996 Strynadka NC, Jensen SE, Alzari PM, James MN. A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex. Nature Structural Biology. 3: 290-7. PMID 8605632  1
1996 Strynadka NC, Eisenstein M, Katchalski-Katzir E, Shoichet BK, Kuntz ID, Abagyan R, Totrov M, Janin J, Cherfils J, Zimmerman F, Olson A, Duncan B, Rao M, Jackson R, Sternberg M, et al. Molecular docking programs successfully predict the binding of a beta-lactamase inhibitory protein to TEM-1 beta-lactamase. Nature Structural Biology. 3: 233-9. PMID 8605624 DOI: 10.1038/nsb0396-233  0.6
1995 Paetzel M, Chernaia M, Strynadka N, Tschantz W, Cao G, Dalbey RE, James MN. Crystallization of a soluble, catalytically active form of Escherichia coli leader peptidase. Proteins. 23: 122-5. PMID 8539246 DOI: 10.1002/prot.340230115  0.6
1994 Strynadka NC, Jensen SE, Johns K, Blanchard H, Page M, Matagne A, Frère JM, James MN. Structural and kinetic characterization of a beta-lactamase-inhibitor protein. Nature. 368: 657-60. PMID 8145854 DOI: 10.1038/368657a0  0.6
1994 Huang K, Strynadka NC, Bernard VD, Peanasky RJ, James MN. The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase. Structure (London, England : 1993). 2: 679-89. PMID 7922044  1
1992 Fraser ME, Strynadka NC, Bartlett PA, Hanson JE, James MN. Crystallographic analysis of transition-state mimics bound to penicillopepsin: phosphorus-containing peptide analogues. Biochemistry. 31: 5201-14. PMID 1606144  0.6
1992 Blechner SL, Olah GA, Strynadka NC, Hodges RS, Trewhella J. 4Ca2+.troponin C forms dimers in solution at neutral pH that dissociate upon binding various peptides: small-angle X-ray scattering studies of peptide-induced structural changes. Biochemistry. 31: 11326-34. PMID 1445871 DOI: 10.1021/bi00161a010  0.6
1992 Strynadka NC, Adachi H, Jensen SE, Johns K, Sielecki A, Betzel C, Sutoh K, James MN. Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution. Nature. 359: 700-5. PMID 1436034 DOI: 10.1038/359700a0  1
1991 Brito RM, Putkey JA, Strynadka NC, James MN, Rosevear PR. Comparative NMR studies on cardiac troponin C and a mutant incapable of binding calcium at site II. Biochemistry. 30: 10236-45. PMID 1931952  1
1991 Strynadka NC, James MN. Lysozyme revisited: crystallographic evidence for distortion of an N-acetylmuramic acid residue bound in site D. Journal of Molecular Biology. 220: 401-24. PMID 1856865  1
1991 McPhalen CA, Strynadka NC, James MN. Calcium-binding sites in proteins: a structural perspective. Advances in Protein Chemistry. 42: 77-144. PMID 1793008  1
1990 Strynadka NC, James MN. Model for the interaction of amphiphilic helices with troponin C and calmodulin. Proteins. 7: 234-48. PMID 2362945 DOI: 10.1002/prot.340070305  1
1989 Strynadka NC, James MN. Crystal structures of the helix-loop-helix calcium-binding proteins. Annual Review of Biochemistry. 58: 951-98. PMID 2673026 DOI: 10.1146/  1
1988 Strynadka NC, James MN. Two trifluoperazine-binding sites on calmodulin predicted from comparative molecular modeling with troponin-C. Proteins. 3: 1-17. PMID 3375233 DOI: 10.1002/prot.340030102  1
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