William H. Pearson - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
synthetic organic chemistry with a focus on the area of heterocyclic chemistry
Website:
http://um2017.org/faculty-history/faculty/william-hardy-pearson

92 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2008 Aponick A, Dietz AL, Pearson WH. 2-(3-Pyrrolin-1-yl)-1,4-naphthoquinones: Photoactivated alkylating agents European Journal of Organic Chemistry. 4264-4276. DOI: 10.1002/ejoc.200800482  1
2007 Pearson WH, Kropf JE, Choy AL, Lee IY, Kampf JW. Approach to the homoerythrina alkaloids using a tandem N-alkylation/azomethine ylide cycloaddition. The Journal of Organic Chemistry. 72: 4135-48. PMID 17465572 DOI: 10.1021/jo0703799  1
2006 Pearson WH, Aponick A, Dietz AL. Synthesis of N,N-bis(3-butenyl)amines from 2-azaallyl dication synthetic equivalents and conversion to 2,3,6,7-tetrahydroazepines by ring-closing metathesis. The Journal of Organic Chemistry. 71: 3533-9. PMID 16626137 DOI: 10.1021/jo060173s  1
2006 Pearson WH, Aponick A. Formal synthesis of aspidosperma alkaloids via the intramolecular [3 + 2] cycloaddition of 2-azapentdienyllithiums. Organic Letters. 8: 1661-4. PMID 16597135 DOI: 10.1021/ol0602506  1
2006 Hering KW, Artz JD, Pearson WH, Marletta MA. The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase. Bioorganic & Medicinal Chemistry Letters. 16: 618-21. PMID 16326101 DOI: 10.1016/j.bmcl.2005.10.093  1
2005 Hering KW, Karaveg K, Moremen KW, Pearson WH. A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum alpha-mannosidase I. The Journal of Organic Chemistry. 70: 9892-904. PMID 16292820 DOI: 10.1021/jo0516382  1
2005 Pearson WH, Berry DA, Stoy P, Jung KY, Sercel AD. Fluorous affinity purification of oligonucleotides. The Journal of Organic Chemistry. 70: 7114-22. PMID 16122230 DOI: 10.1021/jo050795y  1
2004 Pearson WH, Lee IY, Mi Y, Stoy P. Total synthesis of the Kopsia lapidilecta alkaloid (+/-)-lapidilectine B. The Journal of Organic Chemistry. 69: 9109-22. PMID 15609944 DOI: 10.1021/jo048917u  1
2004 Mans DM, Pearson WH. Novel Kumada coupling reaction to access cyclic (2-azaallyl)stannanes. Cycloadditions of cyclic nonstabilized 2-azaallyllithium species derived from cyclic (2-azaallyl)stannanes. The Journal of Organic Chemistry. 69: 6419-26. PMID 15357603 DOI: 10.1021/jo049429p  1
2004 Mans DM, Pearson WH. Total synthesis of (+)-cocaine via desymmetrization of a meso-dialdehyde. Organic Letters. 6: 3305-8. PMID 15355038 DOI: 10.1021/ol048777a  1
2004 Pearson WH, Stoy P, Mi Y. A three-component, one-pot synthesis of indolizidines and related heterocycles via the [3+2] cycloaddition of nonstabilized azomethine ylides. The Journal of Organic Chemistry. 69: 1919-39. PMID 15058937 DOI: 10.1021/jo030334h  1
2004 Pearson WH, Dietz A, Stoy P. Azomethine ylides from tin-substituted cyclic carbinol amides: a new route to highly substituted pyrrolizidines. Organic Letters. 6: 1005-8. PMID 15012086 DOI: 10.1021/ol0499304  1
2004 Pearson WH, Mans DM, Kampf JW. Cycloadditions of 2-azaallyllithium species with conjugated polyenes. The Journal of Organic Chemistry. 69: 1235-47. PMID 14961676 DOI: 10.1021/jo030306z  1
2004 Stoy P, Rush J, Pearson WH. The synthesis of 9,10-dihydro-9-,10-(methaniminomethano)anthracene and N-protected derivatives via double reductive amination Synthetic Communications. 34: 3481-3489. DOI: 10.1081/SCC-200030972  1
2004 Berry DA, Jung KY, Wise DS, Sercel AD, Pearson WH, Mackie H, Randolph JB, Somers RL. Pyrrolo-dC and pyrrolo-C: Fluorescent analogs of cytidine and 2′-deoxycytidine for the study of oligonucleotides Tetrahedron Letters. 45: 2457-2461. DOI: 10.1016/j.tetlet.2004.01.108  1
2003 Pearson WH, Stoy P. Cycloadditions of nonstabilized 2-azaallyllithiums (2-azaallyl anions) and azomethine ylides with alkenes: [3+2] Approaches to pyrrolidines and application to alkaloid total synthesis Synlett. 903-921.  1
2002 Pearson WH, Mans DM, Kampf JW. Cycloadditions of nonstabilized 2-azaallyllithiums with cycloheptatriene. Organic Letters. 4: 3099-102. PMID 12201726 DOI: 10.1021/ol026423i  1
2002 Pearson WH, Guo L, Jewell TM. Preparation of immobilized swainsonine analogs on solid support Tetrahedron Letters. 43: 2175-2178. DOI: 10.1016/S0040-4039(02)00254-X  1
2002 Pearson WH, Walters MA, Rosen MK, Harter WG. Generation and cycloaddition of semi-stabilized 2-azaallyllithiums viaelectrocyclic ring-opening or cycloreversion reactions Arkivoc. 2002: 91-111.  1
2002 Pearson WH, Ren Y, Powers JD. A synthesis of (1S,2R,8R,8aR)-8-hydroxy-1,2-(isopropylidinedioxy)indolizidin-5-one from D-ribose: Improved access to (-)-swainsonine and its analogs Heterocycles. 58: 421-430.  1
2002 Pearson WH. Alkaloid synthesis via [3+2] cycloadditions Pure and Applied Chemistry. 74: 1339-1347.  1
2001 Pearson WH, Mi Y, Lee IY, Stoy P. Total synthesis of the Kopsia lapidilecta alkaloid (+/-)-lapidilectine B. Journal of the American Chemical Society. 123: 6724-5. PMID 11439072 DOI: 10.1021/ja016007d  1
2001 Pearson WH, Aponick A. Double allylation reactions of (2-azaallyl)stannanes: synthesis of N,N-bis(3-butenyl)amines and their conversion to 2,3,6,7-tetrahydroazepines via ring-closing metathesis. Organic Letters. 3: 1327-30. PMID 11348226 DOI: 10.1021/ol015711w  1
2001 Pearson WH, Hembre EJ. Synthesis and mannosidase inhibitory activity of 6- and 7-substituted analogs of swainsonine Tetrahedron Letters. 42: 8273-8276. DOI: 10.1016/S0040-4039(01)01778-6  1
2001 Pearson WH, Guo L. Synthesis and mannosidase inhibitory activity of 3-benzyloxymethyl analogs of swainsonine Tetrahedron Letters. 42: 8267-8271. DOI: 10.1016/S0040-4039(01)01777-4  1
2001 Pearson WH, Stevens EP, Aponick A. Studies on the asymmetric cycloaddition of 2-azaallyl anions with alkenes Tetrahedron Letters. 42: 7361-7365. DOI: 10.1016/S0040-4039(01)01539-8  1
2001 Pearson WH, Walavalkar R. A Schmidt route to 1-azabicyclo[x.y.0]alkanes: A comparison of carbocation stabilizing groups Tetrahedron. 57: 5081-5089. DOI: 10.1016/S0040-4020(01)00353-2  1
2000 Pearson WH, Hutta DA, Fang WK. Azidomercurations of alkenes: mercury-promoted Schmidt reactions. The Journal of Organic Chemistry. 65: 8326-32. PMID 11101392 DOI: 10.1021/jo001181q  1
2000 Pearson WH, Fang W. Synthesis of benzo-fused 1-azabicyclo[m.n.0]alkanes via the Schmidt reaction: a formal synthesis of gephyrotoxin. The Journal of Organic Chemistry. 65: 7158-74. PMID 11031044 DOI: 10.1021/jo0011383  1
2000 Pearson WH, Hines JV. Total syntheses of (+)-australine and (-)-7-epialexine. The Journal of Organic Chemistry. 65: 5785-93. PMID 10970325 DOI: 10.1021/jo000689q  1
1999 Pearson WH, Ren Y. Synthetic Studies on Lepadiformine Using the 2-Azaallyl Anion Method. The Journal of Organic Chemistry. 64: 688-689. PMID 11674129 DOI: 10.1021/jo982120j  1
1999 Clark RB, Pearson WH. Nonstabilized N-unsubstituted azomethine ylides: a synthesis of indolizidine 239CD. Organic Letters. 1: 349-51. PMID 10822574  1
1999 Pearson WH, Clark RB. Formation and cycloaddition of nonstabilized N-unsubstituted azomethine ylides from (2-azaallyl)stannanes and (2-azaallyl)silanes Tetrahedron Letters. 40: 4467-4471. DOI: 10.1016/S0040-4039(99)00744-3  1
1998 Pearson WH, Suga H. Total synthesis of (±)-quinolizidine 217A Journal of Organic Chemistry. 63: 9910-9918. DOI: 10.1021/jo981695d  1
1998 Pearson WH, Stevens EP. Cycloaddition of heteroatom-substituted 2-azaallyl anions with alkenes. Synthesis of 1-pyrrolines and bridged azabicyclic compounds Journal of Organic Chemistry. 63: 9812-9827. DOI: 10.1021/jo981457i  1
1998 Pearson WH, Lian BW. Application of the 2-azaallyl anion cycloaddition method to an enantioselective total synthesis of (+)-coccinine Angewandte Chemie - International Edition. 37: 1724-1726. DOI: 10.1002/(SICI)1521-3773(19980703)37:12<1724::AID-ANIE1724>3.0.CO;2-8  1
1998 Pearson WH, Lovering FE. Assembly of 3a-Arylperhydroindoles by the Intramolecular Cycloaddition of 2-Azaallyl Anions with Alkenes. Total Syntheses of (±)-Crinine, (±)-6-Epicrinine, (-)-Amabiline, and (-)-Augustamine Journal of Organic Chemistry. 63: 3607-3617.  1
1997 Pearson WH, Clark RB. Solid-phase synthesis of pyrrolidines via 2-azaallyl anion cycloadditions with alkenes Tetrahedron Letters. 38: 7669-7672. DOI: 10.1016/S0040-4039(97)10001-6  1
1997 Pearson WH, Mi Y. The generation and cycloaddition of 2-azaallyl anions and azomethine ylides from a common precursor. A novel synthesis of indolizidines and other heterocycles Tetrahedron Letters. 38: 5441-5444. DOI: 10.1016/S0040-4039(97)01217-3  1
1997 Pearson WH, Barta NS, Kampf JW. Synthetic studies on the perhydropyrrolo[2,1-j]quinoline marine alkaloids lepadiformine and cyclindricine C using a 2-azapentadienyl anion cycloaddition. Synthesis of 2,13-diepilepadiformine (or 2-epi-11-deoxycylindricine C) Tetrahedron Letters. 38: 3369-3372. DOI: 10.1016/S0040-4039(97)00632-1  1
1997 Hembre EJ, Pearson WH. Synthesis of the novel mannosidase inhibitors (3R)- and (3S)-3-(hydroxymethyl)swainsonine Tetrahedron. 53: 11021-11032. DOI: 10.1016/S0040-4020(97)00362-1  1
1997 Pearson WH, Fang WK. Reactions of azides with electrophiles: New methods for the generation of cationic 2-azabutadienes. Synthesis of 1,2,3,4-tetrahydroquinolines and 1,2-dihydroquinolines via a hetero Diels-Alder reaction Israel Journal of Chemistry. 37: 39-46.  1
1996 Pearson WH, Hembre EJ. A Practical Synthesis of (-)-Swainsonine. The Journal of Organic Chemistry. 61: 7217-7221. PMID 11667634 DOI: 10.1021/jo961101b  1
1996 Pearson WH, Hembre EJ. Synthesis of novel glycosidase-inhibitory hydroxymethyl-substituted polyhydroxylated indolizidines: Ring-expanded analogs of the pyrrolizidine alkaloids alexine and australine Journal of Organic Chemistry. 61: 5546-5556. DOI: 10.1021/jo960610a  1
1996 Pearson WH, Hembre EJ. Synthesis of tetrahydroxyquinolizidines: Ring-expanded analogs of the mannosidase inhibitor swainsonine Journal of Organic Chemistry. 61: 5537-5545. DOI: 10.1021/jo960609b  1
1996 Pearson WH, Gallagher BM. The intramolecular Schmidt reaction of azides with tertiary alcohols: Synthesis of 5-(α-naphthyl)- and 5-(β-naphthyl)indolizidines as potential dopamine analogs and non-opiate antinociceptive agents Tetrahedron. 52: 12039-12048. DOI: 10.1016/0040-4020(96)00723-5  1
1996 Schkeryantz JM, Pearson WH. An efficient synthesis of (±)-crinane using an intramolecular azide-olefin cycloaddition Tetrahedron. 52: 3107-3116. DOI: 10.1016/0040-4020(95)01098-X  1
1996 Pearson WH. Aliphatic Azides as Lewis Bases. Application to the Synthesis of Heterocyclic Compounds Journal of Heterocyclic Chemistry. 33: 1489-1496.  1
1995 Pearson WH, Lovering FE. Short, efficient syntheses of the Amaryllidaceae alkaloids (-)-amabiline and (-)-augustamine via intramolecular 2-azaallyl anion cycloadditions Journal of the American Chemical Society. 117: 12336-12337. DOI: 10.1021/ja00154a037  1
1995 Pearson WH, Fang WK. Synthesis of amines by the intermolecular schmidt reaction of aliphatic azides with carbocations The Journal of Organic Chemistry. 60: 4960-4961.  1
1994 Pearson WH, Stevens EP. Generation and cycloaddition of heteroatom-substituted 2-azaallyl anions with alkenes and alkynes. Synthesis of 1-pyrrolines and pyrroles Tetrahedron Letters. 35: 2641-2644. DOI: 10.1016/S0040-4039(00)76994-2  1
1994 Pearson WH, Walavalkar R. Synthesis of (±)tylophorine by the intramolecular cycloaddition of an azide with an ω-chloroalkene Tetrahedron. 50: 12293-12304. DOI: 10.1016/S0040-4020(01)89538-7  1
1994 Pearson WH, Lovering FE. Application of the 2-azaallyl anion cycloaddition method to syntheses of (±)-crinine and (±)-6-epicrinine Tetrahedron Letters. 35: 9173-9176. DOI: 10.1016/0040-4039(94)88457-9  1
1994 Pearson WH, Jacobs VA. Generation of 2-azapentadienyl anions and their cycloaddition with alkenes. Synthesis of 2-alkenylpyrrolidines Tetrahedron Letters. 35: 7001-7004. DOI: 10.1016/0040-4039(94)88209-6  1
1994 Pearson WH, Postich MJ. Approach to 6a-epipretazettine and 6a-epiprecriwelline via an intramolecular 2-azaallyl anion cycloaddition reaction Journal of Organic Chemistry. 59: 5662-5671.  1
1994 Pearson WH, Fang WK, Kampf JW. [3 + 2] and [3 + 3] cycloadditions of azides with allylic carbocations Journal of Organic Chemistry. 59: 2682-2684.  1
1994 Pearson WH, Stevens EP. Synthesis of N-[1-(trialkylstannyl)alkyl]amides and -amines by the displacement of benzotriazoles with trialkylstannyllithiums Synthesis. 904-906.  1
1993 Pearson WH, Hembre EJ. Synthesis of novel polyhydroxylated quinolizidines: Ring expanded analogs of glycosidase inhibitory indolizidines Tetrahedron Letters. 34: 8221-8224. DOI: 10.1016/S0040-4039(00)61395-3  1
1993 Pearson WH, Walavalkar R, Schkeryantz JM, Fang WK, Blickensdorf JD. Intramolecular schmidt reactions of azides with carbocations: Synthesis of bridged-bicyclic and fused-bicyclic tertiary amines Journal of the American Chemical Society. 115: 10183-10194.  1
1993 Pearson WH, Lindbeck AC, Kampf JW. Configurational stability of chiral, nonconjugated nitrogen-substituted organolithium compounds generated by tin-lithium exchange of N-[(1-Tri-n-butylstannyl)alkyl]imidazolidin-2-ones and -oxazolidin-2-ones Journal of the American Chemical Society. 115: 2622-2633.  1
1992 Pearson WH, Schkeryantz JM. An intramolecular, Schmidt reaction of an alkyl azide with a carbocation. The generation and rearrangement of a conformationally restricted secondary aminodiazonium ion Tetrahedron Letters. 33: 5291-5294. DOI: 10.1016/S0040-4039(00)79075-7  1
1992 Pearson WH, Bergmeier SC, Williams JP. Synthesis of (-)-slaframine and related indolizidines Journal of Organic Chemistry. 57: 3977-3987.  1
1992 Pearson WH, Postich MJ. An improved method for the preparation of pyrrolidines by the cycloaddition of nonstabilized 2-azaallyl anions with alkenes Journal of Organic Chemistry. 57: 6354-6357.  1
1992 Pearson WH, Schkeryantz JM. Lithium perchlorate-assisted substitution reactions of allylic acetates and allylic alcohols Journal of Organic Chemistry. 57: 2986-2987.  1
1992 Pearson WH, Schkeryantz JM. Synthesis of (±)-γ-lycorane by the intramolecular cycloaddition of an azide with an ω-chloroalkene Journal of Organic Chemistry. 57: 6783-6789.  1
1992 Pearson WH, Szura DP, Postich MJ. Generation of 2-azaallyl anions by the transmetalation of N-(trialkylstannyl)methanimines. Pyrrolidine synthesis by [3 + 2] cycloadditions with alkenes Journal of the American Chemical Society. 114: 1329-1345.  1
1991 Pearson WH, Hines JV. A synthesis of (+)-7-Epiaustraline and (-)-7-Epialexine Tetrahedron Letters. 32: 5513-5516. DOI: 10.1016/0040-4039(91)80071-D  1
1991 Pearson WH, Lindbeck AC. Stereochemical studies on chiral, nonconjugated, nitrogen-substituted carbanions generated by tin-lithium exchange Journal of the American Chemical Society. 113: 8546-8548.  1
1991 Pearson WH, Bergmeier SC. A synthesis of (-)-slaframine and (-)-1,8a-diepislaframine Journal of Organic Chemistry. 56: 1976-1978.  1
1991 Pearson WH, Schkeryantz JM. A stereoselective synthesis of 1-substituted 2-alkoxy-1,3-butadienes by the fragmentation of β-hydroxysilanes Synthesis. 342-346.  1
1990 Heidt. PC, Bergmeier SC, Pearson WH. Synthesis of indolidines by the 1,3-dipolar cycloaddition of azides with methylenecyclopropanes followed by cyclopropyumine rearrangement Tetrahedron Letters. 31: 5441-5444. DOI: 10.1016/S0040-4039(00)97867-5  1
1990 Pearson WH, Lin KC. The intramolecular cycloaddition of azides with ω-chloroalkenes. A facile route to (±)-swainsonine and other indolizidine alkaloids Tetrahedron Letters. 31: 7571-7574. DOI: 10.1016/S0040-4039(00)97301-5  1
1990 Pearson WH, Bergmeier SC, Degan S, Lin KC, Poon YF, Schkeryantz JM, Williams JP. Synthesis of pyrrolizidines and indolizidines by the intramolecular cycloaddition of azides with electron-rich 1,3-dienes. A synthetic equivalent of a nitrene-diene cycloaddition Journal of Organic Chemistry. 55: 5719-5738.  1
1989 Pearson WH, Lin KC, Poon YF. A stereoselective route to 2-(phenylthio)-1,3-butadienes Journal of Organic Chemistry. 54: 5814-5819. DOI: 10.1021/jo00285a031  1
1989 Pearson WH, Poon YF. Assembly of the gephyrotoxin ring system via a [4+1] approach to 3-pyrrolines Tetrahedron Letters. 30: 6661-6664. DOI: 10.1016/S0040-4039(00)70644-7  1
1989 Pearson WH, Lindbeck AC. Generation of synthetic equivalents of RCH(Li)NH2 for the synthesis of primary amines. Tin-lithium exchange on carbamate-protected (α-aminoalkyl)stannanes Journal of Organic Chemistry. 54: 5651-5654.  1
1989 Pearson WH, Hines JV. Synthesis of β-amino-α-hydroxy acids via aldol condensation of a chiral glycolate enolate. Synthesis of (-)-bestatin Journal of Organic Chemistry. 54: 4235-4237.  1
1989 Wojciechowski BJ, Pearson WH, Kuczkowski RL. Stereochemical effects in the ozonolysis of (E)- and (Z)-1-ethoxypropene Journal of Organic Chemistry. 54: 115-121.  1
1988 Pearson WH, Szura DP, Harter WG. Transmetallation of n-(trialkylstannyl)methylimines. A new method for the generation and cycloaddition of 2-azaallyl anions Tetrahedron Letters. 29: 761-764. DOI: 10.1016/S0040-4039(00)80203-8  1
1987 Pearson WH, Cheng MC. Spiro asymmetric induction. 3. Synthesis of optically pure syn or anti α,β-dihydroxy esters by the aldol condensation of chiral glycolate enolates Journal of Organic Chemistry. 52: 3176-3178.  1
1987 Pearson WH, Cheng MC. Synthesis of 1,3-dioxolan-4-ones. An improved procedure Journal of Organic Chemistry. 52: 1353-1355.  1
1986 Pearson WH, Celebuski JE, Poon YF, Dixon BR, Glans JH. Intramolecular azide-diene cycloadditions. An approach to fused bicyclic 3-pyrrolines based on a one-pot nitrene-diene cycloaddition equivalent Tetrahedron Letters. 27: 6301-6304. DOI: 10.1016/S0040-4039(00)87792-8  1
1986 Pearson WH, Walters MA, Oswell KD. Intramolecular 2-azaallyl anion cycloadditions. application to the synthesis of fused bicyclic pyrrolidines [17] Journal of the American Chemical Society®. 108: 2769-2771.  1
1986 Pearson WH, Cheng MC. Spiro asymmetric induction. Synthesis of optically pure α-hydroxy acid derivatives by alkylation of a chiral glycolate enolate Journal of Organic Chemistry. 51: 3746-3748.  1
1985 Pearson WH. Synthesis of fused pyrrolines by the intramolecular cycloadition of azides application to the pyrrolizidine alkaloids Tetrahedron Letters. 26: 3527-3530. DOI: 10.1016/S0040-4039(00)89182-0  1
1985 Danishefsky SJ, Pearson WH, Segmuller BE. Total synthesis of (±)-3-deoxy-D-manno-2-octulopyranosate (KDO) Journal of the American Chemical Society. 107: 1280-1285.  1
1985 Danishefsky SJ, Pearson WH, Harvey DF, Maring CJ, Springer JP. Chelation-controlled facially selective cyclocondensation reactions of chiral alkoxy aldehydes: Syntheses of a mouse androgen and of a carbon-linked disaccharide Journal of the American Chemical Society. 107: 1256-1268.  1
1984 Danishefsky SJ, Pearson WH, Harvey DF. On the relationship of topological and diastereofacial control in the Lewis acid catalyzed cyclocondensation reaction of alkoxyaldehydes with activated dienes: Metal tunable asymmetric induction Journal of the American Chemical Society. 106: 2456-2458.  1
1984 Danishefsky SJ, Pearson WH, Harvey DF. Diastereofacial control in the Lewis acid catalyzed cyclocondensation reaction of aldehydes with activated dienes: A synthesis of the Mus musculus pheromone Journal of the American Chemical Society. 106: 2455-2456.  1
1983 Danishefsky SJ, Pearson WH. A New strategy for the synthesis of spiroketals [4] Journal of Organic Chemistry. 48: 3865-3866.  1
1983 Trost BM, Pearson WH. Sulfur activation of azides toward addition of organometallics. Amination of aliphatic carbanions Journal of the American Chemical Society. 105: 1054-1056.  1
1981 Trost BM, Pearson WH. Azidomethyl phenyl sulfide. A synthon for NH2 + Journal of the American Chemical Society. 103: 2483-2485.  1
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