| Year |
Citation |
Score |
| 2022 |
Vasu D, Li H, Hardy CD, Poulos TL, Silverman RB. 2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry. 69: 116878. PMID 35772285 DOI: 10.1016/j.bmc.2022.116878 |
0.301 |
|
| 2022 |
Yun J, Jeong D, Xie Z, Lee S, Kim J, Surmeier DJ, Silverman RB, Kang S. Palladium-Catalyzed α-Arylation of Cyclic β-Dicarbonyl Compounds for the Synthesis of Ca1.3 Inhibitors. Acs Omega. 7: 14252-14263. PMID 35559207 DOI: 10.1021/acsomega.2c00889 |
0.653 |
|
| 2022 |
Zhu W, Butrin A, Melani RD, Doubleday PF, Ferreira GM, Tavares MT, Habeeb Mohammad TS, Beaupre BA, Kelleher NL, Moran GR, Liu D, Silverman RB. Rational Design, Synthesis, and Mechanism of (3,4)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase. Journal of the American Chemical Society. PMID 35293728 DOI: 10.1021/jacs.2c00924 |
0.325 |
|
| 2021 |
Cooper G, Kang S, Perez-Rosello T, Guzman JN, Galtieri D, Xie Z, Kondapalli J, Mordell J, Silverman RB, Surmeier DJ. Correction to A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of Ca1.3 L-Type Calcium Channels. Acs Chemical Biology. PMID 34133142 DOI: 10.1021/acschembio.1c00368 |
0.657 |
|
| 2021 |
Zhu W, Doubleday PF, Butrin A, Weerawarna PM, Melani RD, Catlin DS, Dwight TA, Liu D, Kelleher NL, Silverman RB. Remarkable and Unexpected Mechanism for ()-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. Journal of the American Chemical Society. PMID 34014654 DOI: 10.1021/jacs.1c03572 |
0.793 |
|
| 2021 |
Weerawarna PM, Moschitto MJ, Silverman RB. Theoretical and Mechanistic Validation of Global Kinetic Parameters of the Inactivation of GABA Aminotransferase by OV329 and CPP-115. Acs Chemical Biology. PMID 33735567 DOI: 10.1021/acschembio.0c00784 |
0.781 |
|
| 2020 |
Shen S, Doubleday PF, Weerawarna PM, Zhu W, Kelleher NL, Silverman RB. Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase. Acs Medicinal Chemistry Letters. 11: 1949-1955. PMID 33062178 DOI: 10.1021/Acsmedchemlett.9B00672 |
0.79 |
|
| 2020 |
Cooper G, Kang S, Perez-Rosello T, Guzman JN, Galtieri D, Xie Z, Kondapalli J, Mordell J, Silverman RB, Surmeier DJ. A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of Ca1.3 L-Type Calcium Channels. Acs Chemical Biology. PMID 32881483 DOI: 10.1021/Acschembio.0C00577 |
0.673 |
|
| 2020 |
Catlin DS, Reidl CT, Trzupek TR, Silverman RB, Cannon B, Becker DP, Liu D. (S)-4-Amino-5-phenoxypentanoate Designed as a Potential Selective Agonist of the Bacterial Transcription Factor GabR. Protein Science : a Publication of the Protein Society. PMID 32557944 DOI: 10.1002/Pro.3905 |
0.635 |
|
| 2020 |
Rey S, Maton G, Satake S, Llano I, Kang S, Surmeier DJ, Silverman RB, Collin T. Physiological involvement of presynaptic L-type voltage dependent calcium channels in GABA release of cerebellar molecular layer interneurons. Journal of Neurochemistry. PMID 32491217 DOI: 10.1111/Jnc.15100 |
0.681 |
|
| 2020 |
Cinelli MA, Reidl CT, Li H, Chreifi G, Poulos TL, Silverman RB. First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. Journal of Medicinal Chemistry. PMID 32302123 DOI: 10.1021/Acs.Jmedchem.9B01573 |
0.425 |
|
| 2020 |
Zhu W, Doubleday PF, Catlin DS, Weerawarna PM, Butrin A, Shen S, Wawrzak Z, Kelleher NL, Liu D, Silverman RB. A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid. Journal of the American Chemical Society. PMID 32114761 DOI: 10.1021/Jacs.0C00193 |
0.804 |
|
| 2019 |
Moschitto MJ, Doubleday PF, Catlin DS, Kelleher NL, Liu D, Silverman RB. Mechanism of Inactivation of Ornithine Aminotransferase by (1 S,3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid. Journal of the American Chemical Society. PMID 31251613 DOI: 10.1021/Jacs.9B03254 |
0.623 |
|
| 2019 |
Cinelli MA, Do HT, Miley GP, Silverman RB. Inducible nitric oxide synthase: Regulation, structure, and inhibition. Medicinal Research Reviews. PMID 31192483 DOI: 10.1002/Med.21599 |
0.375 |
|
| 2019 |
Do HT, Li H, Chreifi G, Poulos TL, Silverman RB. Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. Journal of Medicinal Chemistry. PMID 30802056 DOI: 10.2210/Pdb6Ngl/Pdb |
0.388 |
|
| 2019 |
Zheng J, Jeon S, Jiang W, Burbulla LF, Ysselstein D, Oevel K, Krainc D, Silverman RB. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. Journal of Medicinal Chemistry. PMID 30645117 DOI: 10.1021/Acs.Jmedchem.8B01294 |
0.311 |
|
| 2019 |
Lu X, Yang S, Silverman RB. Monoamine Oxidase-Catalyzed Oxidative Rearrangement of trans,trans-1-(Aminomethyl)-2-methoxy-3-phenylcyclopropane. The Journal of Organic Chemistry. 61: 8961-8966. PMID 11667878 DOI: 10.1021/Jo961540A |
0.354 |
|
| 2018 |
Do HT, Wang HY, Li H, Chreifi G, Poulos TL, Silverman RB. Correction to Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. Journal of Medicinal Chemistry. PMID 30592215 DOI: 10.1021/Acs.Jmedchem.8B01866 |
0.381 |
|
| 2018 |
Li H, Evenson RJ, Chreifi G, Silverman RB, Poulos TL. The Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-Carboximidamides. Biochemistry. PMID 30335983 DOI: 10.1021/Acs.Biochem.8B00895 |
0.434 |
|
| 2018 |
Moschitto MJ, Silverman RB. Synthesis of ( S)-3-Amino-4-(difluoromethylenyl)-cyclopent-1-ene-1-carboxylic Acid (OV329), a Potent Inactivator of γ-Aminobutyric Acid Aminotransferase. Organic Letters. PMID 30009604 DOI: 10.1021/Acs.Orglett.8B01872 |
0.32 |
|
| 2018 |
Zheng J, Chen L, Skinner OS, Ysselstein D, Remis J, Lansbury P, Skerlj R, Mrosek M, Heunisch U, Krapp S, Charrow J, Schwake M, Kelleher NL, Silverman RB, Krainc D. β-Glucocerebrosidase modulators promote dimerization of β-glucocerebrosidase and reveal an allosteric binding site. Journal of the American Chemical Society. PMID 29676907 DOI: 10.1021/Jacs.7B13003 |
0.318 |
|
| 2018 |
Silverman RB. Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions. Chemical Reviews. PMID 29569907 DOI: 10.1021/Acs.Chemrev.8B00009 |
0.374 |
|
| 2018 |
Juncosa JI, Takaya K, Le HV, Moschitto MJ, Weerawarna PM, Mascarenhas R, Liu D, Dewey SL, Silverman RB. Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. Journal of the American Chemical Society. PMID 29381352 DOI: 10.1021/Jacs.7B10965 |
0.788 |
|
| 2017 |
Do HT, Wang HY, Li H, Chreifi G, Poulos TL, Silverman RB. Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. Journal of Medicinal Chemistry. PMID 29091437 DOI: 10.1021/Acs.Jmedchem.7B01356 |
0.412 |
|
| 2017 |
Mascarenhas R, Le HV, Clevenger KD, Lehrer HJ, Ringe D, Kelleher NL, Silverman RB, Liu D. Correction to Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry. PMID 29045130 DOI: 10.1021/Acs.Biochem.7B00961 |
0.787 |
|
| 2017 |
Mascarenhas R, Le HV, Clevenger KD, Lehrer HJ, Ringe D, Kelleher NL, Silverman RB, Liu D. Selective Targeting by a Mechanism-based Inactivator against PLP-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry. PMID 28816437 DOI: 10.1021/Acs.Biochem.7B00499 |
0.809 |
|
| 2017 |
Pensa AV, Cinelli MA, Li H, Chreifi G, Mukherjee P, Roman LJ, Martásek P, Poulos TL, Silverman RB. Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors. Journal of Medicinal Chemistry. PMID 28776992 DOI: 10.1021/Acs.Jmedchem.7B00835 |
0.418 |
|
| 2017 |
Cinelli MA, Li H, Chreifi G, Poulos TL, Silverman RB. Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. Journal of Medicinal Chemistry. PMID 28422508 DOI: 10.1021/Acs.Jmedchem.7B00259 |
0.434 |
|
| 2017 |
Wu R, Sanishvili R, Belitsky BR, Juncosa JI, Le HV, Lehrer HJ, Farley M, Silverman RB, Petsko GA, Ringe D, Liu D. PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28348215 DOI: 10.1073/Pnas.1703019114 |
0.789 |
|
| 2017 |
Zhang Y, Benmohamed R, Zhang W, Kim J, Edgerly CK, Zhu Y, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Correction to "Chiral Cyclohexane 1,3-Diones as Inhibitors of Mutant SOD1-Dependent Protein Aggregation for the Treatment of ALS". Acs Medicinal Chemistry Letters. 8: 377. PMID 28337334 DOI: 10.1021/Acsmedchemlett.7B00070 |
0.459 |
|
| 2016 |
Holden JK, Lewis MC, Cinelli MA, Abdullatif Z, Pensa AV, Silverman RB, Poulos TL. Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-based Inhibitors. Biochemistry. PMID 27607918 DOI: 10.1021/Acs.Biochem.6B00786 |
0.379 |
|
| 2016 |
Zheng J, Chen L, Schwake M, Silverman RB, Krainc D. Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators. Journal of Medicinal Chemistry. PMID 27598312 DOI: 10.1021/Acs.Jmedchem.6B00930 |
0.324 |
|
| 2016 |
Li H, Wang HY, Kang S, Silverman RB, Poulos TL. Electrostatic control of isoform selective inhibitor binding in nitric oxide synthase. Biochemistry. PMID 27250740 DOI: 10.1021/Acs.Biochem.6B00261 |
0.74 |
|
| 2016 |
Xie CB, Haris Shaikh L, Garg S, Tanriver G, Teo AE, Zhou J, Maniero C, Zhao W, Kang S, Silverman RB, Azizan EA, Brown MJ. Regulation of aldosterone secretion by Cav1.3. Scientific Reports. 6: 24697. PMID 27098837 DOI: 10.1038/Srep24697 |
0.678 |
|
| 2016 |
Wang HY, Qin Y, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-based Scaffold with a Pyridine Linker. Journal of Medicinal Chemistry. PMID 27050842 DOI: 10.1021/Acs.Jmedchem.6B00273 |
0.403 |
|
| 2016 |
Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB. Correction to Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. Journal of Medicinal Chemistry. PMID 26807481 DOI: 10.1021/Acs.Jmedchem.6B00036 |
0.727 |
|
| 2016 |
Yang S, Yang Z, Silverman RB, Poulos T, Meyskens FL. Abstract 4744: Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma Cancer Research. 76: 4744-4744. DOI: 10.1158/1538-7445.Am2016-4744 |
0.326 |
|
| 2015 |
Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB. Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. Journal of Medicinal Chemistry. PMID 26469213 DOI: 10.1021/Acs.Jmedchem.5B01330 |
0.747 |
|
| 2015 |
Teixeira-Castro A, Jalles A, Esteves S, Kang S, da Silva Santos L, Silva-Fernandes A, Neto MF, Brielmann RM, Bessa C, Duarte-Silva S, Miranda A, Oliveira S, Neves-Carvalho A, Bessa J, Summavielle T, ... Silverman RB, et al. Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain : a Journal of Neurology. PMID 26373603 DOI: 10.1093/Brain/Awv262 |
0.675 |
|
| 2015 |
Zigmond E, Ya'acov AB, Lee H, Lichtenstein Y, Shalev Z, Smith Y, Zolotarov L, Ziv E, Kalman R, Le HV, Lu H, Silverman RB, Ilan Y. Suppression of Hepatocellular Carcinoma by Inhibition of Overexpressed Ornithine Aminotransferase. Acs Medicinal Chemistry Letters. 6: 840-844. PMID 26288681 DOI: 10.1021/Acsmedchemlett.5B00153 |
0.565 |
|
| 2015 |
Zhang Y, Zhao KT, Fox SG, Kim J, Kirsch DR, Ferrante RJ, Morimoto RI, Silverman RB. Tertiary amine pyrazolones and their salts as inhibitors of mutant superoxide dismutase 1-dependent protein aggregation for the treatment of amyotrophic lateral sclerosis. Journal of Medicinal Chemistry. PMID 26186011 DOI: 10.1021/Acs.Jmedchem.5B00561 |
0.322 |
|
| 2015 |
Kang S, Li H, Tang W, Martásek P, Roman LJ, Poulos TL, Silverman RB. 2-Aminopyridines with a Truncated Side Chain to Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. Journal of Medicinal Chemistry. PMID 26120733 DOI: 10.1021/Acs.Jmedchem.5B00573 |
0.713 |
|
| 2015 |
Lee H, Le HV, Wu R, Doud E, Sanishvili R, Kellie JF, Compton PD, Pachaiyappan B, Liu D, Kelleher NL, Silverman RB. Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid. Acs Chemical Biology. PMID 26110556 DOI: 10.1021/Acschembio.5B00212 |
0.717 |
|
| 2015 |
Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL. Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus. Chemistry & Biology. 22: 785-92. PMID 26091171 DOI: 10.1016/J.Chembiol.2015.05.013 |
0.697 |
|
| 2015 |
Holden JK, Dejam D, Lewis MC, Huang H, Kang S, Jing Q, Xue F, Silverman RB, Poulos TL. Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase. Biochemistry. 54: 4075-82. PMID 26062720 DOI: 10.1021/Acs.Biochem.5B00431 |
0.726 |
|
| 2015 |
Khanfar MA, Quinti L, Wang H, Nobles J, Kazantsev AG, Silverman RB. Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors. Acs Medicinal Chemistry Letters. 6: 607-11. PMID 26005542 DOI: 10.1021/Acsmedchemlett.5B00075 |
0.398 |
|
| 2015 |
Tang W, Li H, Doud EH, Chen Y, Choing S, Plaza C, Kelleher NL, Poulos TL, Silverman RB. Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid. Journal of the American Chemical Society. 137: 5980-9. PMID 25874809 DOI: 10.1021/Jacs.5B01202 |
0.421 |
|
| 2015 |
Tang W, Li H, Poulos TL, Silverman RB. Mechanistic studies of inactivation of inducible nitric oxide synthase by amidines. Biochemistry. 54: 2530-8. PMID 25811913 DOI: 10.1021/Acs.Biochem.5B00135 |
0.399 |
|
| 2015 |
Le HV, Hawker DD, Wu R, Doud E, Widom J, Sanishvili R, Liu D, Kelleher NL, Silverman RB. Design and mechanism of tetrahydrothiophene-based γ-aminobutyric acid aminotransferase inactivators. Journal of the American Chemical Society. 137: 4525-33. PMID 25781189 DOI: 10.1021/Jacs.5B01155 |
0.799 |
|
| 2015 |
Lee H, Doud EH, Wu R, Sanishvili R, Juncosa JI, Liu D, Kelleher NL, Silverman RB. Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115). Journal of the American Chemical Society. 137: 2628-40. PMID 25616005 DOI: 10.1021/Ja512299N |
0.8 |
|
| 2015 |
Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf NA, Wang H, Silverman RB, Ayata C, Maxwell MM, Steegborn C, Schwarzschild MA, Outeiro TF, Kazantsev AG. The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. Plos One. 10: e0116919. PMID 25608039 DOI: 10.1371/Journal.Pone.0116919 |
0.394 |
|
| 2015 |
Holden JK, Kang S, Hollingsworth SA, Li H, Lim N, Chen S, Huang H, Xue F, Tang W, Silverman RB, Poulos TL. Structure-based design of bacterial nitric oxide synthase inhibitors. Journal of Medicinal Chemistry. 58: 994-1004. PMID 25522110 DOI: 10.1021/Jm501723P |
0.732 |
|
| 2015 |
Mukherjee P, Li H, Sevrioukova I, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase. Journal of Medicinal Chemistry. 58: 1067-88. PMID 25489882 DOI: 10.1021/Jm501719E |
0.438 |
|
| 2015 |
Kang S, Watanabe M, Jacobs JC, Yamaguchi M, Dahesh S, Nizet V, Leyh TS, Silverman RB. Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability. European Journal of Medicinal Chemistry. 90: 448-61. PMID 25461893 DOI: 10.1016/J.Ejmech.2014.11.040 |
0.693 |
|
| 2015 |
Lee H, Juncosa JI, Silverman RB. Ornithine aminotransferase versus GABA aminotransferase: implications for the design of new anticancer drugs. Medicinal Research Reviews. 35: 286-305. PMID 25145640 DOI: 10.1002/Med.21328 |
0.808 |
|
| 2015 |
Silverman RB, Holladay MW. The Organic Chemistry of Drug Design and Drug Action: Third Edition The Organic Chemistry of Drug Design and Drug Action: Third Edition. 1-517. |
0.215 |
|
| 2014 |
Li H, Jamal J, Plaza C, Pineda SH, Chreifi G, Jing Q, Cinelli MA, Silverman RB, Poulos TL. Structures of human constitutive nitric oxide synthases. Acta Crystallographica. Section D, Biological Crystallography. 70: 2667-74. PMID 25286850 DOI: 10.1107/S1399004714017064 |
0.399 |
|
| 2014 |
Davydov R, Labby KJ, Chobot SE, Lukoyanov DA, Crane BR, Silverman RB, Hoffman BM. Enzymatic and cryoreduction EPR studies of the hydroxylation of methylated N(ω)-hydroxy-L-arginine analogues by nitric oxide synthase from Geobacillus stearothermophilus. Biochemistry. 53: 6511-9. PMID 25251261 DOI: 10.1021/Bi500485Z |
0.772 |
|
| 2014 |
Jing Q, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase. Bioorganic & Medicinal Chemistry Letters. 24: 4504-10. PMID 25149509 DOI: 10.1016/J.Bmcl.2014.07.079 |
0.415 |
|
| 2014 |
Li H, Jamal J, Delker S, Plaza C, Ji H, Jing Q, Huang H, Kang S, Silverman RB, Poulos TL. The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases. Biochemistry. 53: 5272-9. PMID 25089924 DOI: 10.1021/Bi500561H |
0.727 |
|
| 2014 |
Trippier PC, Zhao KT, Fox SG, Schiefer IT, Benmohamed R, Moran J, Kirsch DR, Morimoto RI, Silverman RB. Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis. Acs Chemical Neuroscience. 5: 823-9. PMID 25001311 DOI: 10.1021/Cn500147V |
0.777 |
|
| 2014 |
Kang S, Tang W, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity Journal of Medicinal Chemistry. 57: 4382-4396. PMID 24758147 DOI: 10.1021/Jm5004182 |
0.736 |
|
| 2014 |
Jing Q, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors. Acs Medicinal Chemistry Letters. 5: 56-60. PMID 24660051 DOI: 10.1021/Ml400381S |
0.386 |
|
| 2014 |
Khanfar MA, Quinti L, Wang H, Choi SH, Kazantsev AG, Silverman RB. Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors European Journal of Medicinal Chemistry. 76: 414-426. PMID 24602787 DOI: 10.1016/J.Ejmech.2014.02.003 |
0.363 |
|
| 2014 |
Mukherjee P, Cinelli MA, Kang S, Silverman RB. Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain. Chemical Society Reviews. 43: 6814-38. PMID 24549364 DOI: 10.1039/C3Cs60467E |
0.713 |
|
| 2014 |
Cinelli MA, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition Journal of Medicinal Chemistry. 57: 1513-1530. PMID 24472039 DOI: 10.1021/Jm401838X |
0.449 |
|
| 2014 |
Huang H, Li H, Yang S, Chreifi G, Martásek P, Roman LJ, Meyskens FL, Poulos TL, Silverman RB. Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma Journal of Medicinal Chemistry. 57: 686-700. PMID 24447275 DOI: 10.1021/Jm401252E |
0.417 |
|
| 2014 |
Trippier PC, Benmohamed R, Kirsch DR, Silverman RB. Corrigendum to “Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1” [Bioorg. Med. Chem. Lett. 22 (2012) 6647–6650] Bioorganic & Medicinal Chemistry Letters. 24: 691. DOI: 10.1016/J.Bmcl.2013.12.027 |
0.637 |
|
| 2013 |
Holden JK, Li H, Jing Q, Kang S, Richo J, Silverman RB, Poulos TL. Structural and biological studies on bacterial nitric oxide synthase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 110: 18127-31. PMID 24145412 DOI: 10.1073/Pnas.1314080110 |
0.718 |
|
| 2013 |
Walia A, Kang S, Silverman RB. Microwave-assisted protection of primary amines as 2,5-dimethylpyrroles and their orthogonal deprotection Journal of Organic Chemistry. 78: 10931-10937. PMID 24073706 DOI: 10.1021/Jo401778E |
0.7 |
|
| 2013 |
Jing Q, Li H, Chreifi G, Roman LJ, Martásek P, Poulos TL, Silverman RB. Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 5674-9. PMID 23993333 DOI: 10.1016/J.Bmcl.2013.08.034 |
0.412 |
|
| 2013 |
Jing Q, Li H, Fang J, Roman LJ, Martásek P, Poulos TL, Silverman RB. In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures. Bioorganic & Medicinal Chemistry. 21: 5323-31. PMID 23867386 DOI: 10.1016/J.Bmc.2013.06.014 |
0.431 |
|
| 2013 |
Juncosa JI, Lee H, Silverman RB. Two continuous coupled assays for ornithine-δ-aminotransferase Analytical Biochemistry. 440: 145-149. PMID 23747282 DOI: 10.1016/J.Ab.2013.05.025 |
0.794 |
|
| 2013 |
Kang S, Cooper G, Dunne SF, Luan CH, James Surmeier D, Silverman RB. Antagonism of L-type Ca2+ channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics. Bioorganic & Medicinal Chemistry. 21: 4365-73. PMID 23688558 DOI: 10.1016/J.Bmc.2013.04.054 |
0.698 |
|
| 2013 |
Kang S, Cooper G, Dunne SF, Luan CH, Surmeier DJ, Silverman RB. Structure-activity relationship of N,N'-disubstituted pyrimidinetriones as Ca(V)1.3 calcium channel-selective antagonists for Parkinson's disease. Journal of Medicinal Chemistry. 56: 4786-97. PMID 23651412 DOI: 10.1021/Jm4005048 |
0.703 |
|
| 2013 |
Labby KJ, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. Methylated Nω-hydroxy-l-arginine analogues as mechanistic probes for the second step of the nitric oxide synthase-catalyzed reaction Biochemistry. 52: 3062-3073. PMID 23586781 DOI: 10.1021/Bi301571V |
0.792 |
|
| 2013 |
Huang H, Silverman RB. Recent advances toward improving the bioavailability of neuronal nitric oxide synthase inhibitors Current Topics in Medicinal Chemistry. 13: 803-812. PMID 23578024 DOI: 10.2174/1568026611313070003 |
0.401 |
|
| 2013 |
Trippier PC, Jansen Labby K, Hawker DD, Mataka JJ, Silverman RB. Target- and mechanism-based therapeutics for neurodegenerative diseases: Strength in numbers Journal of Medicinal Chemistry. 56: 3121-3147. PMID 23458846 DOI: 10.1021/Jm3015926 |
0.787 |
|
| 2013 |
Huang H, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Structure-guided design of selective inhibitors of neuronal nitric oxide synthase Journal of Medicinal Chemistry. 56: 3024-3032. PMID 23451760 DOI: 10.1021/Jm4000984 |
0.433 |
|
| 2013 |
Zhang Y, Benmohamed R, Huang H, Chen T, Voisine C, Morimoto RI, Kirsch DR, Silverman RB. Arylazanylpyrazolone derivatives as inhibitors of mutant superoxide dismutase 1 dependent protein aggregation for the treatment of amyotrophic lateral sclerosis. Journal of Medicinal Chemistry. 56: 2665-75. PMID 23445362 DOI: 10.1021/Jm400079A |
0.48 |
|
| 2013 |
Li H, Xue F, Kraus JM, Ji H, Labby KJ, Mataka J, Delker SL, Martásek P, Roman LJ, Poulos TL, Silverman RB. Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 21: 1333-1343. PMID 23352768 DOI: 10.1016/J.Bmc.2012.12.019 |
0.805 |
|
| 2013 |
Juncosa JI, Groves AP, Xia G, Silverman RB. Probing the steric requirements of the γ-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin. Bioorganic & Medicinal Chemistry. 21: 903-11. PMID 23306054 DOI: 10.1016/J.Bmc.2012.12.009 |
0.815 |
|
| 2013 |
Yang Z, Misner B, Ji H, Poulos TL, Silverman RB, Meyskens FL, Yang S. Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma Antioxidants and Redox Signaling. 19: 433-447. PMID 23199242 DOI: 10.1089/Ars.2012.4563 |
0.358 |
|
| 2013 |
Doukov T, Li H, Sharma A, Martell JD, Soltis SM, Silverman RB, Poulos TL. Correction to “Temperature-Dependent Spin Crossover in Neuronal Nitric Oxide Synthase Bound with the Heme-Coordinating Thioether Inhibitors” Journal of the American Chemical Society. 135: 7080-7080. DOI: 10.1021/Ja3105472 |
0.395 |
|
| 2012 |
Silverman RB, Candiotti KA, Gitlin MC. Tapentadol extended-release: a recent addition to our analgesic armamentarium. Pain Management. 2: 451-6. PMID 24645861 DOI: 10.2217/pmt.12.42 |
0.213 |
|
| 2012 |
Chopra V, Quinti L, Kim J, Vollor L, Narayanan KL, Edgerly C, Cipicchio PM, Lauver MA, Choi SH, Silverman RB, Ferrante RJ, Hersch S, Kazantsev AG. The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Reports. 2: 1492-7. PMID 23200855 DOI: 10.1016/J.Celrep.2012.11.001 |
0.311 |
|
| 2012 |
Kang S, Cooper G, Dunne SF, Dusel B, Luan CH, Surmeier DJ, Silverman RB. CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease. Nature Communications. 3: 1146. PMID 23093183 DOI: 10.1038/Ncomms2149 |
0.671 |
|
| 2012 |
Trippier PC, Benmohammed R, Kirsch DR, Silverman RB. Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1 Bioorganic and Medicinal Chemistry Letters. 22: 6647-6650. PMID 23021992 DOI: 10.1016/J.Bmcl.2012.08.114 |
0.668 |
|
| 2012 |
Hawker DD, Silverman RB. Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase Bioorganic and Medicinal Chemistry. 20: 5763-5773. PMID 22944334 DOI: 10.1016/J.Bmc.2012.08.009 |
0.749 |
|
| 2012 |
Zhang Y, Benmohamed R, Zhang W, Kim J, Edgerly CK, Zhu Y, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS. Acs Medicinal Chemistry Letters. 3: 584-587. PMID 22837812 DOI: 10.1021/Ml3000963 |
0.507 |
|
| 2012 |
Huang H, Ji H, Li H, Jing Q, Labby KJ, Martásek P, Roman LJ, Poulos TL, Silverman RB. Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations. Journal of the American Chemical Society. 134: 11559-72. PMID 22731813 DOI: 10.1021/Ja302269R |
0.797 |
|
| 2012 |
Ji H, Jing Q, Huang J, Silverman RB. Acid-Facilitated Debenzylation of N-Boc, N-Benzyl Double Protected 2-Aminopyridinomethylpyrrolidine Derivatives. Tetrahedron. 68: 1359-1366. PMID 22639474 DOI: 10.1016/J.Tet.2011.12.013 |
0.368 |
|
| 2012 |
Choi SH, Quinti L, Kazantsev AG, Silverman RB. 3-(N-Arylsulfamoyl)benzamides, inhibitors of human sirtuin type 2 (SIRT2) Bioorganic and Medicinal Chemistry Letters. 22: 2789-2793. PMID 22446090 DOI: 10.1016/J.Bmcl.2012.02.089 |
0.353 |
|
| 2012 |
Klaić L, Morimoto RI, Silverman RB. Celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets. Acs Chemical Biology. 7: 928-37. PMID 22380712 DOI: 10.1021/Cb200539U |
0.355 |
|
| 2012 |
Labby KJ, Xue F, Kraus JM, Ji H, Mataka J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 20: 2435-2443. PMID 22370337 DOI: 10.1016/J.Bmc.2012.01.037 |
0.779 |
|
| 2012 |
Kraus JM, Gits HC, Silverman RB. High yielding allylation of a chiral secondary alcohol containing base sensitive functional groups. Tetrahedron Letters. 53: 1319-1322. PMID 22328795 DOI: 10.1016/J.Tetlet.2011.12.120 |
0.352 |
|
| 2012 |
Chen T, Benmohamed R, Kim J, Smith K, Amante D, Morimoto RI, Kirsch DR, Ferrante RJ, Silverman RB. ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis. Journal of Medicinal Chemistry. 55: 515-27. PMID 22191331 DOI: 10.1021/Jm2014277 |
0.473 |
|
| 2012 |
Zhang W, Benmohamed R, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells. Bioorganic & Medicinal Chemistry. 20: 1029-45. PMID 22189273 DOI: 10.1016/J.Bmc.2011.11.039 |
0.315 |
|
| 2012 |
Silverman RB. The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1 S,3 S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile Spasms Journal of Medicinal Chemistry. 55: 567-575. PMID 22168767 DOI: 10.1021/Jm201650R |
0.317 |
|
| 2012 |
Pan Y, Gerasimov MR, Kvist T, Wellendorph P, Madsen KK, Pera E, Lee H, Schousboe A, Chebib M, Bräuner-Osborne H, Craft CM, Brodie JD, Schiffer WK, Dewey SL, Miller SR, ... Silverman RB, et al. (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction Journal of Medicinal Chemistry. 55: 357-366. PMID 22128851 DOI: 10.1021/Jm201231W |
0.388 |
|
| 2012 |
Kraus JM, Gits HC, Silverman RB. High yielding allylation of a chiral secondary alcohol containing base sensitive functional groups Tetrahedron Letters. 53: 1319-1322. DOI: 10.1016/j.tetlet.2011.12.120 |
0.212 |
|
| 2011 |
Klaić L, Trippier PC, Mishra RK, Morimoto RI, Silverman RB. Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol. Journal of the American Chemical Society. 133: 19634-7. PMID 22087583 DOI: 10.1021/Ja208359A |
0.679 |
|
| 2011 |
Gu W, Silverman RB. Synthesis of (S)-2-Boc-Amino-8-(R)-(tert-butyldimethylsilanyloxy) decanoic acid, a Precursor to the Unusual Amino Acid Residue of the Anticancer Agent Microsporin B. Tetrahedron Letters. 52: 5438-5440. PMID 21984850 DOI: 10.1016/J.Tetlet.2011.07.132 |
0.309 |
|
| 2011 |
Watanabe M, Yamaguchi K, Tang W, Yoshida K, Silverman RB, Arisawa M, Shuto S. Synthesis of a series of 3,4-methanoarginines as side-chain conformationally restricted analogues of arginine Bioorganic and Medicinal Chemistry. 19: 5984-5988. PMID 21917467 DOI: 10.1016/J.Bmc.2011.08.049 |
0.351 |
|
| 2011 |
Gu W, Silverman RB. Stereospecific total syntheses of proteasome inhibitors omuralide and lactacystin Journal of Organic Chemistry. 76: 8287-8293. PMID 21916437 DOI: 10.1021/Jo201453X |
0.354 |
|
| 2011 |
Xue F, Kraus JM, Labby KJ, Ji H, Mataka J, Xia G, Li H, Delker SL, Roman LJ, Martásek P, Poulos TL, Silverman RB. Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase Journal of Medicinal Chemistry. 54: 6399-6403. PMID 21809851 DOI: 10.1021/Jm200411J |
0.791 |
|
| 2011 |
Rao S, Lin Z, Drobyshevsky A, Chen L, Ji X, Ji H, Yang Y, Yu L, Derrick M, Silverman RB, Tan S. Involvement of neuronal nitric oxide synthase in ongoing fetal brain injury following near-term rabbit hypoxia-ischemia. Developmental Neuroscience. 33: 288-98. PMID 21757865 DOI: 10.1159/000327241 |
0.311 |
|
| 2011 |
Yu L, Derrick M, Ji H, Silverman RB, Whitsett J, Vásquez-Vivar J, Tan S. Neuronal nitric oxide synthase inhibition prevents cerebral palsy following hypoxia-ischemia in fetal rabbits: Comparison between JI-8 and 7-nitroindazole Developmental Neuroscience. 33: 312-319. PMID 21659718 DOI: 10.1159/000327244 |
0.302 |
|
| 2011 |
Doukov T, Li H, Sharma A, Martell JD, Soltis SM, Silverman RB, Poulos TL. Temperature-dependent spin crossover in neuronal nitric oxide synthase bound with the heme-coordinating thioether inhibitors. Journal of the American Chemical Society. 133: 8326-34. PMID 21534614 DOI: 10.1021/Ja201466V |
0.301 |
|
| 2011 |
Xue F, Fang J, Delker SL, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase Journal of Medicinal Chemistry. 54: 2039-2048. PMID 21410186 DOI: 10.1021/Jm101071N |
0.432 |
|
| 2011 |
Xia G, Benmohamed R, Kim J, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis. Journal of Medicinal Chemistry. 54: 2409-21. PMID 21375347 DOI: 10.1021/Jm101549K |
0.301 |
|
| 2011 |
Chen T, Benmohamed R, Arvanites AC, Ralay Ranaivo H, Morimoto RI, Ferrante RJ, Watterson DM, Kirsch DR, Silverman RB. Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis. Bioorganic & Medicinal Chemistry. 19: 613-22. PMID 21095130 DOI: 10.1016/J.Bmc.2010.10.052 |
0.449 |
|
| 2011 |
Meyskens FL, Yang S, Yang Z, Ji H, Poulos Tl, Silverman RB. Neuronal Nitric Oxide Synthase (nNOS)/NO, An Accelerator of Melanoma Progression, is a Potential Target for Chemoprevention Free Radical Biology and Medicine. 51: S91-S92. DOI: 10.1016/J.Freeradbiomed.2011.10.416 |
0.34 |
|
| 2010 |
Delker SL, Xue F, Li H, Jamal J, Silverman RB, Poulos TL. Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase Biochemistry. 49: 10803-10810. PMID 21138269 DOI: 10.1021/Bi1013479 |
0.421 |
|
| 2010 |
Liu D, Pozharski E, Fu M, Silverman RB, Ringe D. Mechanism of inactivation of escherichia coli aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid Biochemistry. 49: 10507-10515. PMID 21033689 DOI: 10.1021/Bi101325Z |
0.651 |
|
| 2010 |
Ji H, Delker SL, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives Journal of Medicinal Chemistry. 53: 7804-7824. PMID 20958055 DOI: 10.1021/Jm100947X |
0.372 |
|
| 2010 |
Xue F, Li H, Delker SL, Fang J, Martásek P, Roman LJ, Poulos TL, Silverman RB. Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase Journal of the American Chemical Society. 132: 14229-14238. PMID 20843082 DOI: 10.1021/Ja106175Q |
0.396 |
|
| 2010 |
Xue F, Li H, Fang J, Roman LJ, Martásek P, Poulos TL, Silverman RB. Peripheral but crucial: A hydrophobic pocket (Tyr706, Leu 337, and Met336) for potent and selective inhibition of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry Letters. 20: 6258-6261. PMID 20833542 DOI: 10.1016/J.Bmcl.2010.08.096 |
0.443 |
|
| 2010 |
Xue F, Huang J, Ji H, Fang J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 18: 6526-6537. PMID 20673724 DOI: 10.1016/J.Bmc.2010.06.074 |
0.417 |
|
| 2010 |
Lefurgy ST, Rodriguez SB, Park CS, Cahill S, Silverman RB, Leyh TS. Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae. The Journal of Biological Chemistry. 285: 20654-63. PMID 20404339 DOI: 10.1074/Jbc.M109.098350 |
0.372 |
|
| 2010 |
Chang CC, Cao S, Kang S, Kai L, Tian X, Pandey P, Dunne SF, Luan CH, Surmeier DJ, Silverman RB. Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2. Bioorganic & Medicinal Chemistry. 18: 3147-58. PMID 20382537 DOI: 10.1016/J.Bmc.2010.03.038 |
0.659 |
|
| 2010 |
Delker SL, Ji H, Li H, Jamal J, Fang J, Xue F, Silverman RB, Poulos TL. Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model Journal of the American Chemical Society. 132: 5437-5442. PMID 20337441 DOI: 10.1021/Ja910228A |
0.442 |
|
| 2010 |
Lepore BW, Liu D, Peng Y, Fu M, Yasuda C, Manning JM, Silverman RB, Ringe D. Chiral discrimination among aminotransferases: Inactivation by 4-amino-4,5-dihydrothiophenecarboxylic Acid Biochemistry. 49: 3138-3147. PMID 20192272 DOI: 10.1021/Bi902052X |
0.634 |
|
| 2010 |
Heiferman MJ, Salabat MR, Ujiki MB, Strouch MJ, Cheon EC, Silverman RB, Bentrem DJ. Sansalvamide induces pancreatic cancer growth arrest through changes in the cell cycle Anticancer Research. 30: 73-78. PMID 20150619 |
0.21 |
|
| 2010 |
Kudoh T, Park CS, Lefurgy ST, Sun M, Michels T, Leyh TS, Silverman RB. Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae Bioorganic and Medicinal Chemistry. 18: 1124-1134. PMID 20056424 DOI: 10.1016/J.Bmc.2009.12.050 |
0.357 |
|
| 2010 |
Martell JD, Li H, Doukov T, Martásek P, Roman LJ, Soltis M, Poulos TL, Silverman RB. Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency. Journal of the American Chemical Society. 132: 798-806. PMID 20014790 DOI: 10.1021/Ja908544F |
0.375 |
|
| 2010 |
Delker SL, Ji H, Li H, Jamal J, Fang J, Xue F, Silverman RB, Poulos TL. Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal Model Journal of the American Chemical Society. 132: 14688-14688. DOI: 10.1021/Ja107808U |
0.336 |
|
| 2009 |
Xue F, Gu W, Silverman RB. Concise route to the chiral pyrrolidine core of selective inhibitors of neuronal nitric oxide Organic Letters. 11: 5194-5197. PMID 19860389 DOI: 10.1021/Ol902109T |
0.353 |
|
| 2009 |
Silverman RB, Lawton GR, Ranaivo HR, Chico LK, Seo J, Watterson DM. Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration Bioorganic and Medicinal Chemistry. 17: 7593-7603. PMID 19796958 DOI: 10.1016/J.Bmc.2009.08.065 |
0.747 |
|
| 2009 |
Lawton GR, Ji H, Martásek P, Roman LJ, Silverman RB. Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase. Beilstein Journal of Organic Chemistry. 5: 28. PMID 19590740 DOI: 10.3762/Bjoc.5.28 |
0.705 |
|
| 2009 |
Fang J, Ji H, Lawton GR, Xue F, Roman LJ, Silverman RB. L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors Journal of Medicinal Chemistry. 52: 4533-4537. PMID 19537690 DOI: 10.1021/Jm900380J |
0.699 |
|
| 2009 |
Fang J, Silverman RB. A cellular model for screening neuronal nitric oxide synthase inhibitors Analytical Biochemistry. 390: 74-78. PMID 19362065 DOI: 10.1016/J.Ab.2009.04.004 |
0.394 |
|
| 2009 |
Igarashi J, Li H, Jamal J, Ji H, Fang J, Lawton GR, Silverman RB, Poulos TL. Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors. Journal of Medicinal Chemistry. 52: 2060-6. PMID 19296678 DOI: 10.1021/Jm900007A |
0.724 |
|
| 2009 |
Lawton GR, Ralay Ranaivo H, Chico LK, Ji H, Xue F, Martásek P, Roman LJ, Watterson DM, Silverman RB. Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability. Bioorganic & Medicinal Chemistry. 17: 2371-80. PMID 19268602 DOI: 10.1016/J.Bmc.2009.02.017 |
0.713 |
|
| 2009 |
Ji H, Tan S, Igarashi J, Li H, Derrick M, Martásek P, Roman LJ, Vásquez-Vivar J, Poulos TL, Silverman RB. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Annals of Neurology. 65: 209-17. PMID 19235180 DOI: 10.1002/Ana.21555 |
0.381 |
|
| 2009 |
Silverman RB. Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases. Accounts of Chemical Research. 42: 439-51. PMID 19154146 DOI: 10.1021/Ar800201V |
0.449 |
|
| 2009 |
Ji H, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping. Journal of Medicinal Chemistry. 52: 779-97. PMID 19125620 DOI: 10.1021/Jm801220A |
0.415 |
|
| 2008 |
Ji H, Stanton BZ, Igarashi J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors. Journal of the American Chemical Society. 130: 3900-14. PMID 18321097 DOI: 10.1021/Ja0772041 |
0.375 |
|
| 2008 |
Silverman RB. From basic science to blockbuster drug: the discovery of Lyrica. Angewandte Chemie (International Ed. in English). 47: 3500-4. PMID 18307181 DOI: 10.1002/Anie.200704280 |
0.37 |
|
| 2008 |
Zhu Y, Silverman RB. Revisiting heme mechanisms. A perspective on the mechanisms of nitric oxide synthase (NOS), Heme oxygenase (HO), and cytochrome P450s (CYP450s). Biochemistry. 47: 2231-43. PMID 18237198 DOI: 10.1021/Bi7023817 |
0.544 |
|
| 2008 |
Trott A, West JD, Klai? L, Westerheide SD, Silverman RB, Morimoto RI, Morano KA. Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Molecular Biology of the Cell. 19: 1104-12. PMID 18199679 DOI: 10.1091/Mbc.E07-10-1004 |
0.305 |
|
| 2008 |
Clift MD, Silverman RB. Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase Bioorganic and Medicinal Chemistry Letters. 18: 3122-3125. PMID 17988865 DOI: 10.1016/J.Bmcl.2007.10.060 |
0.394 |
|
| 2008 |
Ji H, Igarashi J, Li H, Martásek P, Roman LJ, Vivar JV, Derrick M, Poulos TL, Tan S, Silverman RB. O69. Prevention of cerebral palsy with de novo designed neuronal nitric oxide synthase selective inhibitors Nitric Oxide. 19: 36. DOI: 10.1016/J.Niox.2008.06.070 |
0.35 |
|
| 2007 |
Clift MD, Ji H, Deniau GP, O'Hagan D, Silverman RB. Enantiomers of 4-amino-3-fluorobutanoic acid as substrates for γ-aminobutyric acid aminotransferase. Conformational probes for GABA binding Biochemistry. 46: 13819-13828. PMID 17988152 DOI: 10.1021/Bi701249Q |
0.354 |
|
| 2007 |
Liu D, Pozharski E, Lepore BW, Fu M, Silverman RB, Petsko GA, Ringe D. Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms". Biochemistry. 46: 10517-27. PMID 17713924 DOI: 10.1021/Bi700663N |
0.615 |
|
| 2007 |
Erdal EP, Martásek P, Roman LJ, Silverman RB. Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry. 15: 6096-108. PMID 17614291 DOI: 10.1016/J.Bmc.2007.06.038 |
0.819 |
|
| 2007 |
Seo J, Igarashi J, Li H, Martasek P, Roman LJ, Poulos TL, Silverman RB. Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water. Journal of Medicinal Chemistry. 50: 2089-99. PMID 17425297 DOI: 10.1021/Jm061305C |
0.591 |
|
| 2007 |
Zhu Y, Silverman RB. Model studies for heme oxygenase-catalyzed porphyrin meso hydroxylation. Organic Letters. 9: 1195-8. PMID 17343390 DOI: 10.1021/Ol063088F |
0.517 |
|
| 2007 |
Yuan H, Silverman RB. Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase. Bioorganic & Medicinal Chemistry Letters. 17: 1651-4. PMID 17267220 DOI: 10.1016/J.Bmcl.2006.12.119 |
0.563 |
|
| 2007 |
Seo J, Martásek P, Roman LJ, Silverman RB. Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry. 15: 1928-38. PMID 17239601 DOI: 10.1016/J.Bmc.2007.01.001 |
0.597 |
|
| 2007 |
Zhu Y, Silverman RB. Electronic effects of peripheral substituents at porphyrin meso positions. The Journal of Organic Chemistry. 72: 233-9. PMID 17194104 DOI: 10.1021/Jo061951J |
0.473 |
|
| 2007 |
Gu W, Cueto M, Jensen PR, Fenical W, Silverman RB. Microsporins A and B: new histone deacetylase inhibitors from the marine-derived fungus Microsporum cf. gypseum and the solid-phase synthesis of microsporin A Tetrahedron. 63: 6535-6541. DOI: 10.1016/J.Tet.2007.04.025 |
0.395 |
|
| 2007 |
Dolphin D, Halko DJ, Silverman RB, Hogenkamp HPC, Anton DL. Cobalamins and Cobinamides Inorganic Syntheses. 20: 134-142. DOI: 10.1002/9780470132517.Ch33 |
0.591 |
|
| 2006 |
Lu H, Silverman RB. Fluorinated conformationally restricted gamma-aminobutyric acid aminotransferase inhibitors. Journal of Medicinal Chemistry. 49: 7404-12. PMID 17149870 DOI: 10.1021/Jm0608715 |
0.4 |
|
| 2006 |
Wang Z, Yuan H, Nikolic D, Van Breemen RB, Silverman RB. (+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway. Biochemistry. 45: 14513-22. PMID 17128990 DOI: 10.1021/Bi061592M |
0.641 |
|
| 2006 |
Ji H, Gómez-Vidal JA, Martasek P, Roman LJ, Silverman RB. Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors. Journal of Medicinal Chemistry. 49: 6254-63. PMID 17034131 DOI: 10.1021/Jm0604124 |
0.413 |
|
| 2006 |
Mbadugha BN, Seo J, Ji H, Martásek P, Roman LJ, Shea TM, Li H, Poulos TL, Silverman RB. Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase. Bioorganic & Medicinal Chemistry. 14: 3681-90. PMID 16480878 DOI: 10.1016/J.Bmc.2006.01.044 |
0.599 |
|
| 2006 |
Gu W, Nusinzon I, Smith RD, Horvath CM, Silverman RB. Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases. Bioorganic & Medicinal Chemistry. 14: 3320-9. PMID 16434199 DOI: 10.1016/J.Bmc.2005.12.047 |
0.321 |
|
| 2006 |
Litzinger EA, Martásek P, Roman LJ, Silverman RB. Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry. 14: 3185-98. PMID 16431112 DOI: 10.1016/J.Bmc.2005.12.043 |
0.819 |
|
| 2006 |
Wang Z, Silverman RB. Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase. Bioorganic & Medicinal Chemistry. 14: 2242-52. PMID 16314106 DOI: 10.1016/J.Bmc.2005.11.010 |
0.485 |
|
| 2006 |
Yuan H, Silverman RB. New substrates and inhibitors of gamma-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: design, synthesis, and biological activity. Bioorganic & Medicinal Chemistry. 14: 1331-8. PMID 16263300 DOI: 10.1016/J.Bmc.2005.09.067 |
0.597 |
|
| 2006 |
Crittenden DL, Park A, Qiu J, Silverman RB, Duke RK, Johnston GA, Jordan MJ, Chebib M. Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. Bioorganic & Medicinal Chemistry. 14: 447-55. PMID 16183289 DOI: 10.1016/J.Bmc.2005.08.037 |
0.309 |
|
| 2006 |
Igarashi J, Li H, Flinspach III ML, Jamal J, Yang W, Gomez-Vidal JA, Litzinger EA, Huang H, Silverman RB, Poulos TL. 1P157 Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases(5. Heme protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) Seibutsu Butsuri. 46: S186. DOI: 10.2142/Biophys.46.S186_1 |
0.788 |
|
| 2006 |
Lawton GR, Ji H, Silverman RB. Remote protection prevents unwanted cyclizations with 2-aminopyridines Tetrahedron Letters. 47: 6113-6115. DOI: 10.1016/J.Tetlet.2006.06.091 |
0.648 |
|
| 2006 |
Seo J, Silverman RB. Synthesis of arginine-containing hydroxamate dipeptidomimetics Tetrahedron Letters. 47: 4069-4073. DOI: 10.1016/J.Tetlet.2006.03.190 |
0.533 |
|
| 2005 |
Li H, Flinspach ML, Igarashi J, Jamal J, Yang W, Gómez-Vidal JA, Litzinger EA, Huang H, Erdal EP, Silverman RB, Poulos TL. Exploring the binding conformations of bulkier dipeptide amide inhibitors in constitutive nitric oxide synthases. Biochemistry. 44: 15222-9. PMID 16285725 DOI: 10.1021/Bi0513610 |
0.805 |
|
| 2005 |
Erdal EP, Litzinger EA, Seo J, Zhu Y, Ji H, Silverman RB. Selective neuronal nitric oxide synthase inhibitors. Current Topics in Medicinal Chemistry. 5: 603-24. PMID 16101423 DOI: 10.2174/1568026054679317 |
0.786 |
|
| 2005 |
Liu S, Gu W, Lo D, Ding XZ, Ujiki M, Adrian TE, Soff GA, Silverman RB. N-methylsansalvamide a peptide analogues. Potent new antitumor agents. Journal of Medicinal Chemistry. 48: 3630-8. PMID 15887970 DOI: 10.1021/Jm048952T |
0.303 |
|
| 2005 |
Vintém AP, Price NT, Silverman RB, Ramsay RR. Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines. Bioorganic & Medicinal Chemistry. 13: 3487-95. PMID 15848762 DOI: 10.1016/J.Bmc.2005.02.061 |
0.325 |
|
| 2005 |
Zhu Y, Nikolic D, Van Breemen RB, Silverman RB. Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification. Journal of the American Chemical Society. 127: 858-68. PMID 15656623 DOI: 10.1021/Ja0445645 |
0.58 |
|
| 2004 |
Wang Z, Silverman RB. Synthesis of cyclopropane isosteres of the antiepilepsy drug vigabatrin and evaluation of their inhibition of GABA aminotransferase. Journal of Enzyme Inhibition and Medicinal Chemistry. 19: 293-301. PMID 15558944 DOI: 10.1080/14756360409162441 |
0.499 |
|
| 2004 |
Storici P, Qiu J, Schirmer T, Silverman RB. Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography. Biochemistry. 43: 14057-63. PMID 15518554 DOI: 10.1021/Bi0487185 |
0.354 |
|
| 2004 |
Pan Y, Calvert K, Silverman RB. Conformationally-restricted vigabatrin analogs as irreversible and reversible inhibitors of gamma-aminobutyric acid aminotransferase. Bioorganic & Medicinal Chemistry. 12: 5719-25. PMID 15465348 DOI: 10.1016/J.Bmc.2004.07.065 |
0.417 |
|
| 2004 |
Schering CA, Zhong B, Woo JC, Silverman RB. Poly(ethylene glycol)-supported enzyme inactivators. Efficient identification of the site of covalent attachment to alpha-chymotrypsin by PEG-TPCK. Bioconjugate Chemistry. 15: 673-6. PMID 15264852 DOI: 10.1021/Bc049940P |
0.767 |
|
| 2004 |
Flinspach M, Li H, Jamal J, Yang W, Huang H, Silverman RB, Poulos TL. Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound. Biochemistry. 43: 5181-7. PMID 15122883 DOI: 10.1021/Bi0361867 |
0.5 |
|
| 2004 |
Gómez-Vidal JA, Martásek P, Roman LJ, Silverman RB. Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors. Journal of Medicinal Chemistry. 47: 703-10. PMID 14736250 DOI: 10.1021/Jm030297M |
0.418 |
|
| 2004 |
Flinspach ML, Li H, Jamal J, Yang W, Huang H, Hah JM, Gómez-Vidal JA, Litzinger EA, Silverman RB, Poulos TL. Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase. Nature Structural & Molecular Biology. 11: 54-9. PMID 14718923 DOI: 10.1038/Nsmb704 |
0.813 |
|
| 2004 |
Fu M, Silverman RB. Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism. Bioorganic & Medicinal Chemistry Letters. 14: 203-6. PMID 14684328 DOI: 10.1016/J.Bmcl.2003.09.065 |
0.329 |
|
| 2004 |
Storici P, De Biase D, Bossa F, Bruno S, Mozzarelli A, Peneff C, Silverman RB, Schirmer T. Structures of γ-Aminobutyric Acid (GABA) Aminotransferase, a Pyridoxal 5′-Phosphate, and [2Fe-2S] Cluster-containing Enzyme, Complexed with γ-Ethynyl-GABA and with the Antiepilepsy Drug Vigabatrin Journal of Biological Chemistry. 279: 363-373. PMID 14534310 DOI: 10.1074/Jbc.M305884200 |
0.348 |
|
| 2004 |
Silverman RB. The Organic Chemistry of Drug Design and Drug Action: Second Edition The Organic Chemistry of Drug Design and Drug Action: Second Edition. 1-617. |
0.217 |
|
| 2003 |
Ji H, Li H, Flinspach M, Poulos TL, Silverman RB. Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors. Journal of Medicinal Chemistry. 46: 5700-11. PMID 14667223 DOI: 10.1021/Jm030301U |
0.399 |
|
| 2003 |
Pan Y, Qiu J, Silverman RB. Design, synthesis, and biological activity of a difluoro-substituted, conformationally rigid vigabatrin analogue as a potent gamma-aminobutyric acid aminotransferase inhibitor. Journal of Medicinal Chemistry. 46: 5292-3. PMID 14640537 DOI: 10.1021/Jm034162S |
0.411 |
|
| 2003 |
Lu X, Nikolic D, Mitchell DJ, van Breemen RB, Mersfelder JA, Hille R, Silverman RB. A mechanism for substrate-Induced formation of 6-hydroxyflavin mononucleotide catalyzed by C30A trimethylamine dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 13: 4129-32. PMID 14592522 DOI: 10.1016/J.Bmcl.2003.07.032 |
0.574 |
|
| 2003 |
Lu X, Rodríguez M, Gu W, Silverman RB. Inactivation of mitochondrial monoamine oxidase B by methylthio-substituted benzylamines Bioorganic and Medicinal Chemistry. 11: 4423-4430. PMID 13129579 DOI: 10.1016/S0968-0896(03)00486-3 |
0.331 |
|
| 2003 |
Hah JM, Martásek P, Roman LJ, Silverman RB. Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Journal of Medicinal Chemistry. 46: 1661-9. PMID 12699384 DOI: 10.1021/Jm0202932 |
0.679 |
|
| 2003 |
Nandi D, Lightcap ES, Koo YK, Lu X, Quancard J, Silverman RB. Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver International Journal of Biochemistry and Cell Biology. 35: 1085-1097. PMID 12672479 DOI: 10.1016/S1357-2725(02)00347-3 |
0.328 |
|
| 2002 |
Lee Y, Ling KQ, Lu X, Silverman RB, Shepard EM, Dooley DM, Sayre LM. 3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases. Journal of the American Chemical Society. 124: 12135-43. PMID 12371853 DOI: 10.1021/Ja0205434 |
0.38 |
|
| 2002 |
Choi S, Silverman RB. Inactivation and inhibition of γ-aminobutyric acid aminotransferase by conformationally restricted vigabatrin analogues Journal of Medicinal Chemistry. 45: 4531-4539. PMID 12238932 DOI: 10.1021/Jm020134I |
0.389 |
|
| 2002 |
Choi S, Storici P, Schirmer T, Silverman RB. Design of a conformationally restricted analogue of the antiepilepsy drug vigabatrin that directs its mechanism of inactivation of γ-aminobutyric acid aminotransferase Journal of the American Chemical Society. 124: 1620-1624. PMID 11853435 DOI: 10.1021/Ja011968D |
0.388 |
|
| 2001 |
Huang H, Martásek P, Roman LJ, Silverman RB. Synthesis and evaluation of dipeptide amides containing N omega-nitroarginine and D-2,4-diaminobutyric acids as inhibitors of neuronal nitric oxide synthase. Journal of Enzyme Inhibition. 16: 233-9. PMID 11697043 DOI: 10.1080/14756360109162371 |
0.482 |
|
| 2001 |
Gómez-Vidal JA, Forrester MT, Silverman RB. Mild and selective sodium azide mediated cleavage of p-nitrobenzoic esters Organic Letters. 3: 2477-2479. PMID 11483039 DOI: 10.1021/Ol016104B |
0.355 |
|
| 2001 |
Hah JM, Roman LJ, Martásek P, Silverman RB. Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. Journal of Medicinal Chemistry. 44: 2667-70. PMID 11472219 DOI: 10.1021/Jm0101491 |
0.673 |
|
| 2001 |
Huang H, Hah JM, Silverman RB. Mechanism of nitric oxide synthase. Evidence that direct hydrogen atom abstraction from the O-H bond of NG-hydroxyarginine is not relevant to the mechanism. Journal of the American Chemical Society. 123: 2674-6. PMID 11456942 DOI: 10.1021/Ja005900U |
0.628 |
|
| 2001 |
Mitchell DJ, Nikolic D, Jang MH, van Breemen RB, Hille R, Silverman RB. Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-alpha-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine. Biochemistry. 40: 8523-30. PMID 11456490 DOI: 10.1021/Bi0105126 |
0.595 |
|
| 2001 |
Mitchell DJ, Nikolic D, van Breemen RB, Silverman RB. Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: mass spectral evidence for the flavin adduct. Bioorganic & Medicinal Chemistry Letters. 11: 1757-60. PMID 11425554 DOI: 10.1016/S0960-894X(01)00302-X |
0.584 |
|
| 2001 |
Mitchell DJ, Nikolic D, Rivera E, Sablin SO, Choi S, van Breemen RB, Singer TP, Silverman RB. Spectrometric evidence for the flavin-1-phenylcyclopropylamine inactivator adduct with monoamine oxidase N. Biochemistry. 40: 5447-56. PMID 11331009 DOI: 10.1021/Bi010388Q |
0.593 |
|
| 2001 |
Woodroofe CC, Zhong B, Lu X, Silverman RB. Anomalous Schmidt reaction products of phenylacetic acid and derivatives Journal of the Chemical Society. Perkin Transactions 2. 55-59. DOI: 10.1039/A907337J |
0.739 |
|
| 2000 |
Lee Y, Martásek P, Roman LJ, Silverman RB. 1H-Pyrazole-1-carboxamidines: New inhibitors of nitric oxide synthase Bioorganic and Medicinal Chemistry Letters. 10: 2771-2774. PMID 11133088 DOI: 10.1016/S0960-894X(00)00573-4 |
0.389 |
|
| 2000 |
Hah JM, Roman LJ, Silverman RB. Deuterium isotope effects and product studies for the oxidation of N(omega)-allyl-L-arginine and N(omega)-allyl-N(omega)-hydroxy-L-arginine by neuronal nitric oxide synthase. Bioorganic & Medicinal Chemistry. 8: 1931-6. PMID 11003138 DOI: 10.1016/S0968-0896(00)00154-1 |
0.618 |
|
| 2000 |
Wang X, Silverman RB. Monoamine oxidase-catalyzed oxidation of endo,endo-2-amino-6-[(Z)-2'-phenyl]ethenylbicyclo[2.2.1]heptane, a potential probe for a radical cation intermediate Bioorganic and Medicinal Chemistry. 8: 1645-1651. PMID 10976512 DOI: 10.1016/S0968-0896(00)00094-8 |
0.37 |
|
| 2000 |
Huang H, Martásek P, Roman LJ, Silverman RB. Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases. Journal of Medicinal Chemistry. 43: 2938-45. PMID 10956202 DOI: 10.1021/Jm000127Z |
0.459 |
|
| 2000 |
Woodroofe CC, Mostashari R, Lu X, Ramsay RR, Silverman RB. Selective inhibition of monoamine oxidase B by aminoethyl substituted benzyl ethers. Journal of Enzyme Inhibition. 15: 11-21. PMID 10850952 DOI: 10.1080/14756369909030338 |
0.376 |
|
| 2000 |
Lee Y, Silverman RB. Traceless solid-phase synthesis of chiral 3-aryl β-amino acid containing peptides using a side-chain-tethered β-amino acid building block Organic Letters. 2: 303-306. PMID 10814308 DOI: 10.1021/Ol9912480 |
0.393 |
|
| 2000 |
Qiu J, Silverman RB. A new class of conformationally rigid analogues of 4-amino-5- halopentanoic acids, potent inactivators of γ-aminobutyric acid aminotransferase Journal of Medicinal Chemistry. 43: 706-720. PMID 10691696 DOI: 10.1021/Jm9904755 |
0.381 |
|
| 2000 |
Koo YK, Nandi D, Silverman RB. The multiple active enzyme species of γ-aminobutyric acid aminotransferase are not isozymes Archives of Biochemistry and Biophysics. 374: 248-254. PMID 10666304 DOI: 10.1006/Abbi.1999.1623 |
0.345 |
|
| 2000 |
Tierney DL, Huang H, Martásek P, Roman LJ, Silverman RB, Hoffman BM. ENDOR spectroscopic evidence for the geometry of binding of retro-inverso-N(ω)-nitroarginine-containing dipeptide amides to neuronal nitric oxide synthase Journal of the American Chemical Society. 122: 7869-7875. DOI: 10.1021/Ja993927B |
0.454 |
|
| 2000 |
Tierney DL, Huang H, Martásek P, Roman LJ, Silverman RB, Masters BSS, Hoffman BM. ENDOR studies of L-arginine and N(G)-hydroxy-L-arginine bound to all three holo-nitric oxide synthase isozymes [10] Journal of the American Chemical Society. 122: 5405-5406. DOI: 10.1021/Ja993685F |
0.413 |
|
| 2000 |
Tantillo DJ, Fukuto JM, Hoffman BM, Silverman RB, Houk KN. Theoretical studies on N(g)-hydroxy-L-arginine and derived radicals: Implications for the mechanism of nitric oxide synthase Journal of the American Chemical Society. 122: 536-537. DOI: 10.1021/Ja991876C |
0.331 |
|
| 2000 |
Tierney DL, Huang H, Martásek P, Roman LJ, Silverman RB, Masters BSS, Hoffman BM. ENDOR Studies ofl-Arginine andNG-Hydroxy-l-Arginine Bound to All Three Holo-Nitric Oxide Synthase Isozymes [J. Am. Chem. Soc.2000,122, 5405−5406]. Journal of the American Chemical Society. 122: 9352-9352. DOI: 10.1021/Ja004658O |
0.428 |
|
| 2000 |
Lee Y, Martasek P, Roman LJ, Masters BSS, Silverman RB. Corrigendum to “Imidazole-containing amino acids as selective inhibitors of nitric oxide synthases” Bioorganic & Medicinal Chemistry. 8: 1523. DOI: 10.1016/S0968-0896(00)00059-6 |
0.4 |
|
| 1999 |
Qiu J, Pingsterhaus JM, Silverman RB. Inhibition and substrate activity of conformationally rigid vigabatrin analogues with γ-aminobutyric acid aminotransferase Journal of Medicinal Chemistry. 42: 4725-4728. PMID 10579835 DOI: 10.1021/Jm990271O |
0.387 |
|
| 1999 |
Lee Y, Martasek P, Roman LJ, Masters BSS, Silverman RB. Imidazole-containing amino acids as selective inhibitors of nitric oxide synthases Bioorganic and Medicinal Chemistry. 7: 1941-1951. PMID 10530943 DOI: 10.1016/S0968-0896(99)00117-0 |
0.426 |
|
| 1999 |
Johnson TR, Silverman RB. Syntheses of (Z)- and (E)-4-amino-2-(trifluoromethyl)-2-butenoic acid and their inactivation of γ-aminobutyric acid aminotransferase Bioorganic and Medicinal Chemistry. 7: 1625-1636. PMID 10482455 DOI: 10.1016/S0968-0896(99)00091-7 |
0.382 |
|
| 1999 |
Fu M, Silverman RB. Isolation and characterization of the product of inactivation of γ-aminobutyric acid aminotransferase by gabaculine Bioorganic and Medicinal Chemistry. 7: 1581-1590. PMID 10482450 DOI: 10.1016/S0968-0896(99)00081-4 |
0.331 |
|
| 1999 |
Huang H, Martasek P, Roman LJ, Masters BS, Silverman RB. N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase. Journal of Medicinal Chemistry. 42: 3147-53. PMID 10447959 DOI: 10.1021/Jm990111C |
0.548 |
|
| 1999 |
Lee Y, Marletta MA, Martasek P, Roman LJ, Masters BS, Silverman RB. Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases. Bioorganic & Medicinal Chemistry. 7: 1097-104. PMID 10428379 DOI: 10.1016/S0968-0896(99)00029-2 |
0.41 |
|
| 1999 |
Tierney DL, Huang H, Martasek P, Masters BS, Silverman RB, Hoffman BM. ENDOR spectroscopic evidence for the position and structure of NG-hydroxy-L-arginine bound to holo-neuronal nitric oxide synthase. Biochemistry. 38: 3704-10. PMID 10090758 DOI: 10.1021/Bi982904R |
0.444 |
|
| 1999 |
Qiu J, Stevenson SH, O'Beirne MJ, Silverman RB. 2,6-Difluorophenol as a bioisostere of a carboxylic acid: bioisosteric analogues of gamma-aminobutyric acid. Journal of Medicinal Chemistry. 42: 329-32. PMID 9925739 DOI: 10.1021/Jm980435L |
0.388 |
|
| 1999 |
Zhong B, Lu X, Silverman RB. Syntheses of amino nitrones. Potential intramolecular traps for radical intermediates in monoamine oxidase-catalyzed reactions. Bioorganic & Medicinal Chemistry. 6: 2405-19. PMID 9925298 DOI: 10.1016/S0968-0896(98)80016-3 |
0.765 |
|
| 1999 |
Yelekçi K, Silverman RB. Effect of the locus of the oxygen atom in amino ethers on the inactivation of monoamine oxidase B. Journal of Enzyme Inhibition. 13: 31-9. PMID 9879512 DOI: 10.3109/14756369809035825 |
0.324 |
|
| 1999 |
Lu X, Silverman RB. Inactivation of monoamine oxidase B by cis- and trans-5-aminomethyl-3-(4-methoxyphenyl)dihydrofuran-2(3H)-ones. Bioorganic & Medicinal Chemistry. 6: 1851-6. PMID 9839014 DOI: 10.1016/S0968-0896(98)00116-3 |
0.391 |
|
| 1999 |
Fu M, Nikolic D, Van Breemen RB, Silverman RB. Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid Journal of the American Chemical Society. 121: 7751-7759. DOI: 10.1021/Ja9915551 |
0.362 |
|
| 1999 |
Fast W, Nikolic D, Van Breemen RB, Silverman RB. Mechanistic studies of the inactivation of inducible nitric oxide synthase by N5-(1-iminoethyl)-L-ornithine (L-NIO) Journal of the American Chemical Society. 121: 903-916. DOI: 10.1021/Ja982318L |
0.642 |
|
| 1998 |
Wang X, Silverman RB. 2-(Iodoethenyl)benzylamines as Potential Probes for Radical Intermediates Formed during Monoamine Oxidase Catalyzed Oxidations. The Journal of Organic Chemistry. 63: 7357-7363. PMID 11672383 DOI: 10.1021/Jo980976I |
0.396 |
|
| 1998 |
Zhou JJP, Zhong B, Silverman RB. An Improved Procedure for the Synthesis of Substituted β-Hydroxynitriles The Journal of Organic Chemistry. 63: 4560-4560. DOI: 10.1021/Jo984005E |
0.712 |
|
| 1998 |
Lu X, Silverman RB. Monoamine Oxidase B-Catalyzed Reactions ofcis- andtrans-5-Aminomethyl-3-(4-Methoxyphenyl)dihydrofuran-2(3H)-ones. Evidence for a Reversible Redox Reaction Journal of the American Chemical Society. 120: 10583-10587. DOI: 10.1021/Ja9811041 |
0.316 |
|
| 1998 |
Olson GT, Fu M, Lau S, Rinehart KL, Silverman RB. An aromatization mechanism of inactivation of γ-aminobutyric acid aminotransferase for the antibiotic L-cycloserine Journal of the American Chemical Society. 120: 2256-2267. DOI: 10.1021/Ja972907B |
0.352 |
|
| 1997 |
Zhang HQ, Fast W, Marletta MA, Martasek P, Silverman RB. Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. Journal of Medicinal Chemistry. 40: 3869-70. PMID 9397167 DOI: 10.1021/Jm970550G |
0.672 |
|
| 1997 |
Fast W, Levsky ME, Marletta MA, Silverman RB. N omega-propargyl-L-arginine and N omega-hydroxy-N omega-propargyl-L-arginine are inhibitors, but not inactivators, of neuronal and macrophage nitric oxide synthases. Bioorganic & Medicinal Chemistry. 5: 1601-8. PMID 9313865 DOI: 10.1016/S0968-0896(97)00109-0 |
0.671 |
|
| 1997 |
Silverman RB, Huang H, Marletta MA, Martasek P. Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters. Journal of Medicinal Chemistry. 40: 2813-7. PMID 9288162 DOI: 10.1021/Jm970200U |
0.53 |
|
| 1997 |
Zhou JJ, Li J, Upadhyaya S, Eaton PE, Silverman RB. 4-substituted cubylcarbinylamines: a new class of mechanism-based monoamine oxidase B inactivators. Journal of Medicinal Chemistry. 40: 1165-8. PMID 9089337 DOI: 10.1021/Jm9606249 |
0.337 |
|
| 1997 |
Silverman RB, Lu X, Blomquist GD, Ding CZ, Yang S. Inactivation of monoamine oxidase B by benzyl 1-(aminomethyl) cyclopropane-1-carboxylate. Bioorganic & Medicinal Chemistry. 5: 297-304. PMID 9061194 DOI: 10.1016/S0968-0896(96)00235-0 |
0.365 |
|
| 1997 |
Silverman RB, Roscher CL. Mechanism-based inactivation of gamma-aminobutyric acid aminotransferase by 3-amino-4-fluorobutanoic acid. Bioorganic & Medicinal Chemistry. 4: 1521-35. PMID 8894109 DOI: 10.1016/0968-0896(96)00145-9 |
0.368 |
|
| 1997 |
Zhong B, Silverman RB. Identification of the active site cysteine in bovine liver monoamine oxidase B Journal of the American Chemical Society. 119: 6690-6691. DOI: 10.1021/Ja9711369 |
0.722 |
|
| 1997 |
Zhang HQ, Dixon RP, Marletta MA, Nikolic D, Van Breemen R, Silverman RB. Mechanism of inactivation of neuronal nitric oxide synthase by N(ω)-allyl-L-arginine Journal of the American Chemical Society. 119: 10888-10902. DOI: 10.1021/Ja964160F |
0.394 |
|
| 1997 |
Fast W, Huff ME, Silverman RB. Time-dependent inhibition of neuronal nitric oxide synthase by N-propargylguanidine Bioorganic and Medicinal Chemistry Letters. 7: 1449-1454. DOI: 10.1016/S0960-894X(97)00241-2 |
0.687 |
|
| 1996 |
Silverman RB, Hawe WP. SAR studies of fluorine-substituted benzylamines and substituted 2-phenylethylamines as substrates and inactivators of monoamine oxidase B. Journal of Enzyme Inhibition. 9: 203-15. PMID 8847600 DOI: 10.3109/14756369509021486 |
0.326 |
|
| 1996 |
Zhou JJ, Zhong B, Silverman RB. Direct continuous fluorometric assay for monoamine oxidase B. Analytical Biochemistry. 234: 9-12. PMID 8742074 DOI: 10.1006/Abio.1996.0041 |
0.736 |
|
| 1996 |
Silverman RB, Olson GT. Inactivation of gamma-aminobutyric acid aminotransferase by L-3-chloroalanine hydroxamate. Bioorganic & Medicinal Chemistry. 3: 11-8. PMID 8612042 DOI: 10.1016/0968-0896(94)00145-S |
0.367 |
|
| 1996 |
Silverman RB. Radical thoughts about the life of MAO. Progress in Brain Research. 106: 23-31. PMID 8584659 DOI: 10.1016/S0079-6123(08)61198-X |
0.394 |
|
| 1996 |
Lightcap ES, Silverman RB. Slow-binding inhibition of gamma-aminobutyric acid aminotransferase by hydrazine analogues. Journal of Medicinal Chemistry. 39: 686-94. PMID 8576911 DOI: 10.1021/Jm950437V |
0.4 |
|
| 1996 |
Silverman RB, Bichler KA, Leon AJ. Unusual Mechanistic Difference in the Inactivation of γ-Aminobutyric Acid Aminotransferase by (E)- and (Z)-4-Amino-6-fluoro-5-hexenoic Acid Journal of the American Chemical Society. 118: 1253-1261. DOI: 10.1021/Ja952789X |
0.346 |
|
| 1996 |
Silverman RB, Bichler KA, Leon AJ. Mechanisms of Inactivation of γ-Aminobutyric Acid Aminotransferase by 4-Amino-5-fluoro-5-hexenoic Acid Journal of the American Chemical Society. 118: 1241-1252. DOI: 10.1021/Ja9527885 |
0.372 |
|
| 1996 |
Leon AJ, Silverman RB. Inactivation of γ-aminobutyric acid aminotransferase by (Z)-4-amino-6-fluoro-5-hexenoic acid: Identification of an active site residue Bioorganic & Medicinal Chemistry Letters. 6: 1319-1322. DOI: 10.1016/0960-894X(96)00226-0 |
0.345 |
|
| 1996 |
Silverman RB, Olson GT. 3-substituted alanines inactivate γ-aminobutyric acid aminotransferase by the same mechanism as do 4-amino-5-halopentanoic acid analogues Bioorganic & Medicinal Chemistry Letters. 6: 143-146. DOI: 10.1016/0960-894X(95)00572-B |
0.352 |
|
| 1995 |
Silverman RB. Mechanism-based enzyme inactivators. Methods in Enzymology. 249: 240-83. PMID 7791614 DOI: 10.1016/0076-6879(95)49038-8 |
0.356 |
|
| 1995 |
Lightcap ES, Hopkins MH, Olson GT, Silverman RB. Time-dependent inhibition of γ-aminobutyric acid aminotransferase, by 3-hydroxybenzylhydrazine Bioorganic and Medicinal Chemistry. 3: 579-585. PMID 7648206 DOI: 10.1016/0968-0896(95)00070-W |
0.393 |
|
| 1995 |
Woo JCG, Wang X, Silverman RB. Monoamine oxidase-catalyzed amine oxidation in organic solvents The Journal of Organic Chemistry. 60: 6235-6236. DOI: 10.1021/Jo00124A054 |
0.398 |
|
| 1995 |
Silverman RB, Olson GT. Mechanism of inactivation of .gamma.-aminobutyric acid aminotransferase by 3-hydrazinopropionic acid The Journal of Organic Chemistry. 60: 6232-6234. DOI: 10.1021/Jo00124A053 |
0.304 |
|
| 1995 |
Zhou JJP, Zhong B, Silverman RB. Improved Procedure for the Synthesis of Substituted .beta.-Hydroxy Nitriles The Journal of Organic Chemistry. 60: 2261-2262. DOI: 10.1021/Jo00112A057 |
0.716 |
|
| 1994 |
Annan N, Silverman RB. New analogues of N-(2-aminoethyl)-4-chlorobenzamide (Ro 16-6491). Some of the most potent monoamine oxidase-B inactivators. Journal of Medicinal Chemistry. 36: 3968-70. PMID 8254625 DOI: 10.1021/Jm00076A026 |
0.365 |
|
| 1994 |
Ding CZ, Silverman RB. Transformation of heterocyclic reversible monoamine oxidase-B inactivators into irreversible inactivators by N-methylation. Journal of Medicinal Chemistry. 36: 3606-10. PMID 8246228 DOI: 10.1021/Jm00075A015 |
0.376 |
|
| 1994 |
Silverman RB, Lu X, Zhou JJP, Swihart A. Monoamine Oxidase B-Catalyzed Oxidation of Cinnamylamine 2,3-Oxide. Further Evidence against a Nucleophilic Mechanism Journal of the American Chemical Society. 116: 11590-11591. DOI: 10.1021/Ja00104A058 |
0.329 |
|
| 1994 |
Silverman RB, Lu X. Evidence against a Nucleophilic Mechanism for Monoamine Oxidase-Catalyzed Amine Oxidation Journal of the American Chemical Society. 116: 4129-4130. DOI: 10.1021/Ja00088A079 |
0.347 |
|
| 1993 |
Ding CZ, Lu X, Nishimura K, Silverman RB. Transformation of monoamine oxidase-B primary amine substrates into time-dependent inhibitors. Tertiary amine homologues of primary amine substrates. Journal of Medicinal Chemistry. 36: 1711-5. PMID 8510099 DOI: 10.1021/Jm00064A004 |
0.377 |
|
| 1993 |
Nishimura K, Lu X, Silverman RB. Inactivation of monoamine oxidase B by analogues of the anticonvulsant agent milacemide (2-(n-pentylamino)acetamide). Journal of Medicinal Chemistry. 36: 446-8. PMID 8474100 DOI: 10.1021/Jm00056A004 |
0.331 |
|
| 1993 |
Silverman RB, Zhou JP, Eaton PE. Inactivation of monoamine oxidase by (aminomethyl)cubane. First evidence for an .alpha.-amino radical during enzyme catalysis Journal of the American Chemical Society. 115: 8841-8842. DOI: 10.1021/Ja00072A048 |
0.301 |
|
| 1993 |
Silverman RB, Cesarone JM, Lu X. Stereoselective ring opening of 1-phenylcyclopropylamine catalyzed by monoamine oxidase-B Journal of the American Chemical Society. 115: 4955-4961. DOI: 10.1021/Ja00065A002 |
0.331 |
|
| 1993 |
Silverman RB, Nishimura K, Lu X. Mechanism of inactivation of monoamine oxidase-B by the anticonvulsant agent milacemide (2-(n-pentylamino)acetamide) Journal of the American Chemical Society. 115: 4949-4954. DOI: 10.1021/Ja00065A001 |
0.394 |
|
| 1993 |
Silverman RB, Ding CZ. Chemical model for a mechanism of inactivation of monoamine oxidase by heterocyclic compounds. Electronic effects on acetal hydrolysis Journal of the American Chemical Society. 115: 4571-4576. DOI: 10.1021/Ja00064A020 |
0.301 |
|
| 1993 |
Silverman RB, Ding CZ, Borrillo JL, Chang JT. Mechanism-based enzyme inactivation via a diactivated cyclopropane intermediate Journal of the American Chemical Society. 115: 2982-2983. DOI: 10.1021/Ja00060A059 |
0.323 |
|
| 1992 |
Taylor CP, Vartanian MG, Andruszkiewicz R, Silverman RB. 3-alkyl GABA and 3-alkylglutamic acid analogues: two new classes of anticonvulsant agents. Epilepsy Research. 11: 103-10. PMID 1618176 DOI: 10.1016/0920-1211(92)90044-T |
0.358 |
|
| 1992 |
Ding Z, Silverman RB. 5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a new class of monoamine oxidase-B inactivators. Journal of Medicinal Chemistry. 35: 885-9. PMID 1548678 DOI: 10.1021/Jm00083A012 |
0.303 |
|
| 1992 |
Hopkins MH, Bichler KA, Su T, Chamberlain CL, Silverman RB. Inactivation of γaminobutyric acid aminotransferase by various amine buffers Journal of Enzyme Inhibition and Medicinal Chemistry. 6: 195-199. PMID 1284956 DOI: 10.3109/14756369209020169 |
0.356 |
|
| 1992 |
Hopkins MH, Silverman RB. βlactams: A new class of conformationally-rigid inhibitors of γaminobutyric acid aminotransferase Journal of Enzyme Inhibition and Medicinal Chemistry. 6: 125-129. PMID 1284428 DOI: 10.3109/14756369209040743 |
0.381 |
|
| 1992 |
Silverman RB, Lu X, Banik GM. Formylsilanes. Chemoenzymic and chemical synthesis of the 2,4-dinitrophenylhydrazones of these apparently air- and water-stable compounds The Journal of Organic Chemistry. 57: 6617-6622. DOI: 10.1021/Jo00050A046 |
0.316 |
|
| 1992 |
Zelechonok Y, Silverman RB. Silver(I)/peroxydisulfate-induced oxidative decarboxylation of amino acids. A chemical model for a possible intermediate in the monoamine oxidase-catalyzed oxidation of amines The Journal of Organic Chemistry. 57: 5787-5790. DOI: 10.1021/Jo00047A045 |
0.362 |
|
| 1991 |
Silverman RB, Andruszkiewicz R, Nanavati SM, Taylor CP, Vartanian MG. 3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase. Journal of Medicinal Chemistry. 34: 2295-8. PMID 2067001 DOI: 10.1021/Jm00111A053 |
0.303 |
|
| 1991 |
Burke JR, Silverman RB. 4-(Oxoalkyl)-substituted GABA analogues as inactivators and substrates of GABA aminotransferase. Journal of Enzyme Inhibition. 5: 199-205. PMID 1669447 DOI: 10.3109/14756369109080058 |
0.356 |
|
| 1991 |
Nanavati SM, Silverman RB. Mechanisms of inactivation of .gamma.-aminobutyric acid aminotransferase by the antiepilepsy drug .gamma.-vinyl GABA (vigabatrin) Journal of the American Chemical Society. 113: 9341-9349. DOI: 10.1021/Ja00024A043 |
0.31 |
|
| 1991 |
Burke JR, Silverman RB. Mechanism of inactivation of .gamma.-aminobutyric acid aminotransferase by 4-amino-5-hexynoic acid (.gamma.-ethynyl GABA) Journal of the American Chemical Society. 113: 9329-9340. DOI: 10.1021/Ja00024A042 |
0.321 |
|
| 1990 |
Ryall RP, Nandi DL, Silverman RB. Substituted vitamin K epoxide analogues. New competitive inhibitors and substrates of vitamin K1 epoxide reductase. Journal of Medicinal Chemistry. 33: 1790-7. PMID 2342073 DOI: 10.1021/Jm00168A038 |
0.306 |
|
| 1990 |
Silverman RB, Nanavati SM. Selective inhibition of gamma-aminobutyric acid aminotransferase by (3R,4R),(3S,4S)- and (3R,4S),(3S,4R)-4-amino-5-fluoro-3-phenylpentanoic acids. Journal of Medicinal Chemistry. 33: 931-6. PMID 2308143 DOI: 10.1021/Jm00165A008 |
0.373 |
|
| 1990 |
Andruszkiewicz R, Barrett AGM, Silverman RB. Chemoenzymatic Synthesis of (R)- and (S)-4-Amino-3-Methylbutanoic Acids Synthetic Communications. 20: 159-166. DOI: 10.1080/00397919008054627 |
0.389 |
|
| 1990 |
Ryall RP, Silverman RB. Synthesis of 2-Substituted-3-Phytyl-1,4-naphthoquinone Epoxides Synthetic Communications. 20: 431-438. DOI: 10.1080/00397919008052785 |
0.313 |
|
| 1989 |
Silverman RB. The potential use of mechanism-based enzyme inactivators in medicine. Journal of Enzyme Inhibition. 2: 73-90. PMID 3069967 DOI: 10.3109/14756368809040714 |
0.355 |
|
| 1989 |
Silverman RB, Oliver JS. 2-(Fluoromethyl)-3-phytyl-1,4-naphthoquinone and its 2,3-epoxide. Inhibition of vitamin K epoxide reductase. Journal of Medicinal Chemistry. 32: 2138-41. PMID 2769684 DOI: 10.1021/Jm00129A019 |
0.397 |
|
| 1989 |
Nanavati SM, Silverman RB. Design of potential anticonvulsant agents: mechanistic classification of GABA aminotransferase inactivators. Journal of Medicinal Chemistry. 32: 2413-21. PMID 2681782 DOI: 10.1021/Jm00131A001 |
0.359 |
|
| 1989 |
Andruszkiewicz R, Silverman RB. A Convenient Synthesis of 3-Alkyl-4-aminobutanoic Acids Synthesis. 1989: 953-955. DOI: 10.1055/S-1989-27443 |
0.302 |
|
| 1989 |
Gates KS, Silverman RB. Model studies for the mechanism of inactivation of monoamine oxidase by 5-(aminomethyl)-3-aryl-2-oxazolidinones Journal of the American Chemical Society. 111: 8891-8895. DOI: 10.1021/Ja00206A018 |
0.326 |
|
| 1988 |
Silverman RB, George C. Inactivation of gamma-aminobutyric acid aminotransferase by (Z)-4-amino-2-fluorobut-2-enoic acid. Biochemistry. 27: 3285-9. PMID 3390432 DOI: 10.1021/Bi00409A024 |
0.366 |
|
| 1988 |
Silverman RB, George C. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (S,E)-4-amino-5-fluoropent-2-enoic acid. Biochemical and Biophysical Research Communications. 150: 942-6. PMID 3342072 DOI: 10.1016/0006-291X(88)90720-6 |
0.34 |
|
| 1988 |
Hiebert CK, Silverman RB. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogues. Inactivation of monoamine oxidase by conformationally rigid analogues of N,N-dimethylcinnamylamine. Journal of Medicinal Chemistry. 31: 1566-70. PMID 3260955 DOI: 10.1021/Jm00403A013 |
0.394 |
|
| 1988 |
Silverman RB, Nandi DL. Reduced thioredoxin: a possible physiological cofactor for vitamin K epoxide reductase. Further support for an active site disulfide. Biochemical and Biophysical Research Communications. 155: 1248-54. PMID 3140805 DOI: 10.1016/S0006-291X(88)81274-9 |
0.325 |
|
| 1987 |
Silverman RB, Invergo BJ. Mechanism of inactivation of gamma-aminobutyrate aminotransferase by 4-amino-5-fluoropentanoic acid. First example of an enamine mechanism for a gamma-amino acid with a partition ratio of 0. Biochemistry. 25: 6817-20. PMID 3801394 DOI: 10.1021/Bi00370A013 |
0.319 |
|
| 1987 |
Silverman RB, Vadnere MK. (Aminoalkyl)trimethylgermanes, the first organogermanium mechanism-based enzyme inactivators: A new class of monoamine oxidase inactivators Bioorganic Chemistry. 15: 328-332. DOI: 10.1016/0045-2068(87)90028-9 |
0.337 |
|
| 1986 |
Silverman RB, Zieske PA. 1-Benzylcyclopropylamine and 1-(phenylcyclopropyl)methylamine: an inactivator and a substrate of monoamine oxidase. Journal of Medicinal Chemistry. 28: 1953-7. PMID 4068012 DOI: 10.1002/Chin.198614361 |
0.4 |
|
| 1986 |
Silverman RB, Zieske PA. 1-Phenylcyclobutylamine, the first in a new class of monoamine oxidase inactivators. Further evidence for a radical intermediate. Biochemistry. 25: 341-6. PMID 3955001 DOI: 10.1021/Bi00350A010 |
0.357 |
|
| 1986 |
Silverman RB, Zieske PA. Identification of the amino acid bound to the labile adduct formed during inactivation of monoamine oxidase by 1-phenylcyclopropylamine. Biochemical and Biophysical Research Communications. 135: 154-9. PMID 3954763 DOI: 10.1016/0006-291X(86)90955-1 |
0.366 |
|
| 1986 |
Silverman RB, Invergo BJ, Mathew J. Inactivation of gamma-aminobutyric acid aminotransferase by (S,E)-4-amino-5-fluoropent-2-enoic acid and effect on the enzyme of (E)-3-(1-aminocyclopropyl)-2-propenoic acid. Journal of Medicinal Chemistry. 29: 1840-6. PMID 3761305 DOI: 10.1021/Jm00160A007 |
0.376 |
|
| 1986 |
Silverman RB, Durkee SC, Invergo BJ. 4-Amino-2-(substituted methyl)-2-butenoic acids: substrates and potent inhibitors of gamma-aminobutyric acid aminotransferase. Journal of Medicinal Chemistry. 29: 764-70. PMID 3701787 DOI: 10.1002/Chin.198638292 |
0.421 |
|
| 1985 |
Silverman RB. Effect of alpha-methylation on inactivation of monoamine oxidase by N-cyclopropylbenzylamine. Biochemistry. 23: 5206-13. PMID 6509020 DOI: 10.1021/Bi00317A019 |
0.322 |
|
| 1985 |
Vazquez ML, Silverman RB. Revised mechanism for inactivation of mitochondrial monoamine oxidase by N-cyclopropylbenzylamine. Biochemistry. 24: 6538-43. PMID 4084536 DOI: 10.1021/Bi00344A035 |
0.301 |
|
| 1985 |
Silverman RB, Zieske PA. Mechanism of inactivation of monoamine oxidase by 1-phenylcyclopropylamine. Biochemistry. 24: 2128-38. PMID 3995007 DOI: 10.1021/Bi00330A005 |
0.382 |
|
| 1985 |
Mukharji I, Silverman RB. Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone. Proceedings of the National Academy of Sciences of the United States of America. 82: 2713-7. PMID 3857611 DOI: 10.1073/Pnas.82.9.2713 |
0.306 |
|
| 1985 |
Mathew J, Invergo BJ, Silverman RB. An Efficient Synthesis of 3-Amino-4-Fluorobutanoic Acid, an Inactivator of GABA Transaminase Synthetic Communications. 15: 377-383. DOI: 10.1080/00397918508063815 |
0.35 |
|
| 1984 |
Silverman RB, Yamasaki RB. Mechanism-based inactivation of mitochondrial monoamine oxidase by N-(1-methylcyclopropyl)benzylamine. Biochemistry. 23: 1322-32. PMID 6712946 DOI: 10.1021/Bi00301A046 |
0.37 |
|
| 1984 |
Silverman RB, Hoffman SJ. The organic chemistry of mechanismbased enzyme inhibition: A chemical approach to drug design Medicinal Research Reviews. 4: 415-447. PMID 6087044 DOI: 10.1002/Chin.198446389 |
0.301 |
|
| 1983 |
Silverman RB, Muztar AJ, Levy MA, Hirsch JD. In vitro and in vivo effects on brain GABA metabolism of (S)-4-amino-5-fluoropentanoic acid, a mechanism-based inactivator of gamma-aminobutyric acid transaminase. Life Sciences. 32: 2717-23. PMID 6855467 DOI: 10.1016/0024-3205(83)90391-0 |
0.361 |
|
| 1981 |
Silverman RB, Levy MA, Muztar AJ, Hirsch JD. In vivo inactivation of gamma-aminobutyric acid-alpha-ketoglutarate transaminase by 4-amino-5-fluoropentanoic acid. Biochemical and Biophysical Research Communications. 102: 520-3. PMID 7306169 DOI: 10.1016/0006-291X(81)91550-3 |
0.333 |
|
| 1981 |
Silverman RB, Hoffman SJ. N-(1-Methyl)cyclopropylbenzylamine: A novel inactivator of mitochondrial monoamine oxidase Biochemical and Biophysical Research Communications. 101: 1396-1401. PMID 7306137 DOI: 10.1016/0006-291X(81)91602-8 |
0.304 |
|
| 1981 |
Silverman RB, Levy MA. Mechanism of inactivation of gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase by 4-amino-5-halopentanoic acids. Biochemistry. 20: 1197-203. PMID 7225323 DOI: 10.1021/Bi00508A022 |
0.365 |
|
| 1981 |
Silverman R, Levy M. Correction - Mechanism of Inactivation of γ-Aminobutyric Acid -α-Ketoglutaric Acid Aminotransferase by 4-Amino-5-halopentanoic Acids Biochemistry. 20: 5094-5094. DOI: 10.1021/Bi00520A607 |
0.388 |
|
| 1980 |
Silverman RB, Levy MA. Irreversible inactivation of pig brain gamma-aminobutyric acid-alpha-ketoglutarate transaminase by 4-amino-5-halopentanoic acids. Biochemical and Biophysical Research Communications. 95: 250-5. PMID 7417253 DOI: 10.1016/0006-291X(80)90731-7 |
0.361 |
|
| 1980 |
Silverman RB, Levy MA. Syntheses of (S)-5-substituted 4-aminopentanoic acids: a new class of .gamma.-aminobutyric acid transaminase inactivators The Journal of Organic Chemistry. 45: 815-818. DOI: 10.1021/Jo01293A011 |
0.318 |
|
| 1980 |
Silverman RB, Dolphin D. Thin-layer chromatography of acid-labile cobalamins Journal of Chromatography A. 194: 273-274. DOI: 10.1016/S0021-9673(00)87309-4 |
0.59 |
|
| 1980 |
SILVERMAN RB, LEVY MA. ChemInform Abstract: SYNTHESES OF (S)-5-SUBSTITUTED 4-AMINOPENTANOIC ACIDS: A NEW CLASS OF Γ-AMINOBUTYRIC ACID TRANSAMINASE INACTIVATORS Chemischer Informationsdienst. 11. DOI: 10.1002/Chin.198029329 |
0.312 |
|
| 1979 |
Silverman RB, Kapili LV. Synthesis of [carboxyl -14C] 5 - fluoroorotic acid Journal of Labelled Compounds and Radiopharmaceuticals. 16: 361-364. DOI: 10.1002/Jlcr.2580160217 |
0.374 |
|
| 1979 |
Silverman RB, Radak RE, Hacker NP. A mild method of hydrolysis of 2,4-dialkoxy-6-substituted pyrimidines to 6-substituted uracils The Journal of Organic Chemistry. 44: 4970-4971. DOI: 10.1002/Chin.198018229 |
0.377 |
|
| 1979 |
SILVERMAN RB. ChemInform Abstract: REACTION OF DIETHYL ACETONEDICARBOXYLATE WITH NITROSYL CHLORIDE Chemischer Informationsdienst. 10. DOI: 10.1002/chin.197925212 |
0.223 |
|
| 1977 |
Silverman RB, Abeles RH. Mechanism of inactivation of gamma-cystathionase by beta,beta,beta-trifluoroalanine. Biochemistry. 16: 5515-20. PMID 921947 DOI: 10.1021/Bi00644A019 |
0.552 |
|
| 1976 |
Silverman RB, Abeles RH. Inactivation of pyridoxal phosphate dependent enzymes by mono- and polyhaloalanines. Biochemistry. 15: 4718-23. PMID 974085 DOI: 10.1021/Bi00666A028 |
0.594 |
|
| 1976 |
Silverman RB, Dolphin D. Model studies for coenzyme B12 dependent enzyme-catalyzed rearrangements. Kinetics and mechanism of decomposition of formylmethylcobalamin and its acetals. Journal of the American Chemical Society. 98: 4633-9. PMID 932368 DOI: 10.1021/Ja00431A049 |
0.666 |
|
| 1976 |
Silverman RB, Dolphin D. Model studies for coenzyme B12 dependent enzyme-catalyzed rearrangements. Evidence for cobalt(III)-olefin pi complexes. Journal of the American Chemical Society. 98: 4626-33. PMID 932367 DOI: 10.1021/Ja00431A048 |
0.659 |
|
| 1976 |
Silverman RB, Dolphin D. Alkylation of the dimethylglyoximato ligands in reduced cobaloxime Canadian Journal of Chemistry. 54: 1425-1427. DOI: 10.1139/V76-203 |
0.628 |
|
| 1976 |
SILVERMAN RB, DOLPHIN D. ChemInform Abstract: ALKYLATION OF THE DIMETHYLGLYOXIMATO LIGANDS IN REDUCED COBALOXIME Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/Chin.197640157 |
0.605 |
|
| 1975 |
Silverman RB, Dolphin D. The hydrolysis of β-acetal cobaloximes Journal of Organometallic Chemistry. 101. DOI: 10.1016/S0022-328X(00)88546-0 |
0.625 |
|
| 1975 |
SILVERMAN RB, DOLPHIN D. ChemInform Abstract: MECHANISM OF HYDROLYSIS OF BETA-ACETAL COBALAMINS Chemischer Informationsdienst. 6. DOI: 10.1002/Chin.197530382 |
0.619 |
|
| 1975 |
Silverman RB, Dolphin D. Reactions Of Vinyl Ethers With Cobalamins And Cobaloxims Cheminform. 6. DOI: 10.1002/Chin.197502399 |
0.611 |
|
| 1974 |
Silverman RB, Dolphin D. Letter: Reactions of vinyl ethers with cobalamins and cobaloximes. Journal of the American Chemical Society. 96: 7094-6. PMID 4474189 DOI: 10.1021/Ja00829A045 |
0.611 |
|
| 1974 |
Silverman RB, Dolphin D, Carty TJ, Krodel EK, Abeles RH. Letter: Formylmethylcobalamin. Journal of the American Chemical Society. 96: 7096-7. PMID 4436511 |
0.663 |
|
| 1973 |
Silverman RB, Dolphin D. A direct method for cobalt-carbon bond formation in cobalt(3)-containing cobalamins and cobaloximes. Further support for cobalt(3). Complexes in coenzyme B 12 dependent rearrangements. Journal of the American Chemical Society. 95: 1686-8. PMID 4689333 DOI: 10.1021/Ja00786A070 |
0.628 |
|
| 1973 |
SILVERMAN RB, DOLPHIN D. ChemInform Abstract: DIREKTE BLDG. EINER KOBALT-KOHLENSTOFF-BINDUNG IN KOBALT(III)-ENTHALTENDEN COBALAMINEN UND COBALOXIMEN DURCH RK. MIT ELEKTRONENREICHEN OLEFINEN, WEITERE UNTERSTUETZUNG FUER KOBALT(III)-KOMPLEXE IN COENZYM B12-ABHAENGIGEN UMLAGERUNGEN Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197320413 |
0.615 |
|
| 1972 |
Silverman RB, Dolphin D, Babior BM. A model for the mechanism of action of coenzyme B 12 dependent enzymes. Evidence for sigma leads to pi rearrangements in cobaloximes. Journal of the American Chemical Society. 94: 4028-32. PMID 5037991 DOI: 10.1021/Ja00766A072 |
0.662 |
|
| 1972 |
SILVERMAN RB, DOLPHIN D, BABIOR BM. ChemInform Abstract: MODELL FUER DEN WIRKUNGSMECHANISMUS FUER COENZYM-B12-ABHAENGIGE ENZYME, NACHWEIS VON SIGMA-PI-UMLAGERUNGEN BEI COBALOXIMEN Chemischer Informationsdienst. 3: no-no. DOI: 10.1002/Chin.197233456 |
0.65 |
|
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