Richard B. Silverman - Publications

Affiliations: 
Northwestern University, Evanston, IL 
Area:
Organic, Synthetic, Bio-Organic, Medicinal Chemistry, Chemical Biology
Website:
http://www.chemistry.northwestern.edu/faculty/richard-silverman.html

230 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Burbulla LF, Jeon S, Zheng J, Song P, Silverman RB, Krainc D. A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson's disease. Science Translational Medicine. 11. PMID 31619543 DOI: 10.1126/scitranslmed.aau6870  0.4
2019 Moschitto MJ, Doubleday PF, Catlin DS, Kelleher NL, Liu D, Silverman RB. Mechanism of Inactivation of Ornithine Aminotransferase by (1 S,3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid. Journal of the American Chemical Society. PMID 31251613 DOI: 10.1021/jacs.9b03254  0.76
2019 Cinelli MA, Do HT, Miley GP, Silverman RB. Inducible nitric oxide synthase: Regulation, structure, and inhibition. Medicinal Research Reviews. PMID 31192483 DOI: 10.1002/med.21599  0.32
2019 Do HT, Li H, Chreifi G, Poulos TL, Silverman RB. Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. Journal of Medicinal Chemistry. PMID 30802056 DOI: 10.1021/acs.jmedchem.8b02032  0.56
2019 Zheng J, Jeon S, Jiang W, Burbulla LF, Ysselstein D, Oevel K, Krainc D, Silverman RB. Correction to Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. Journal of Medicinal Chemistry. PMID 30793892 DOI: 10.1021/acs.jmedchem.9b00284  0.4
2019 Zheng J, Jeon S, Jiang W, Burbulla LF, Ysselstein D, Oevel K, Krainc D, Silverman RB. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. Journal of Medicinal Chemistry. PMID 30645117 DOI: 10.1021/acs.jmedchem.8b01294  0.4
2019 Cinelli MA, Li H, Chreifi G, Poulos TL, Silverman RB. Correction to Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. Journal of Medicinal Chemistry. PMID 30633512 DOI: 10.1021/acs.jmedchem.8b02033  0.56
2018 Do HT, Wang HY, Li H, Chreifi G, Poulos TL, Silverman RB. Correction to Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. Journal of Medicinal Chemistry. PMID 30592215 DOI: 10.1021/acs.jmedchem.8b01866  0.56
2018 Li H, Evenson RJ, Chreifi G, Silverman RB, Poulos TL. The Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-Carboximidamides. Biochemistry. PMID 30335983 DOI: 10.1021/acs.biochem.8b00895  0.56
2018 Moschitto MJ, Silverman RB. Synthesis of ( S)-3-Amino-4-(difluoromethylenyl)-cyclopent-1-ene-1-carboxylic Acid (OV329), a Potent Inactivator of γ-Aminobutyric Acid Aminotransferase. Organic Letters. PMID 30009604 DOI: 10.1021/acs.orglett.8b01872  0.52
2018 Zheng J, Chen L, Skinner OS, Ysselstein D, Remis J, Lansbury P, Skerlj R, Mrosek M, Heunisch U, Krapp S, Charrow J, Schwake M, Kelleher NL, Silverman RB, Krainc D. β-Glucocerebrosidase modulators promote dimerization of β-glucocerebrosidase and reveal an allosteric binding site. Journal of the American Chemical Society. PMID 29676907 DOI: 10.1021/jacs.7b13003  0.72
2018 Miley GP, Rote JC, Silverman RB, Kelleher NL, Thomson RJ. Total Synthesis of Tambromycin Enabled by Indole C-H Functionalization. Organic Letters. PMID 29584440 DOI: 10.1021/acs.orglett.8b00700  0.72
2018 Juncosa JI, Takaya K, Le HV, Moschitto MJ, Weerawarna PM, Mascarenhas R, Liu D, Dewey SL, Silverman RB. Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. Journal of the American Chemical Society. PMID 29381352 DOI: 10.1021/jacs.7b10965  0.76
2017 Do HT, Wang HY, Li H, Chreifi G, Poulos TL, Silverman RB. Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. Journal of Medicinal Chemistry. PMID 29091437 DOI: 10.1021/acs.jmedchem.7b01356  0.56
2017 Mascarenhas R, Le HV, Clevenger KD, Lehrer HJ, Ringe D, Kelleher NL, Silverman RB, Liu D. Correction to Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry. PMID 29045130 DOI: 10.1021/acs.biochem.7b00961  0.76
2017 Mascarenhas R, Le HV, Clevenger KD, Lehrer HJ, Ringe D, Kelleher NL, Silverman RB, Liu D. Selective Targeting by a Mechanism-based Inactivator against PLP-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry. PMID 28816437 DOI: 10.1021/acs.biochem.7b00499  0.76
2017 Pensa AV, Cinelli MA, Li H, Chreifi G, Mukherjee P, Roman LJ, Martásek P, Poulos TL, Silverman RB. Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors. Journal of Medicinal Chemistry. PMID 28776992 DOI: 10.1021/acs.jmedchem.7b00835  0.72
2017 Wu R, Sanishvili R, Belitsky BR, Juncosa JI, Le HV, Lehrer HJ, Farley M, Silverman RB, Petsko GA, Ringe D, Liu D. PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28348215 DOI: 10.1073/pnas.1703019114  0.76
2017 Zhang Y, Benmohamed R, Zhang W, Kim J, Edgerly CK, Zhu Y, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Correction to "Chiral Cyclohexane 1,3-Diones as Inhibitors of Mutant SOD1-Dependent Protein Aggregation for the Treatment of ALS". Acs Medicinal Chemistry Letters. 8: 377. PMID 28337334 DOI: 10.1021/acsmedchemlett.7b00070  1
2016 Holden JK, Lewis MC, Cinelli MA, Abdullatif Z, Pensa AV, Silverman RB, Poulos TL. Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-based Inhibitors. Biochemistry. PMID 27607918 DOI: 10.1021/acs.biochem.6b00786  1
2016 Zheng J, Chen L, Schwake M, Silverman RB, Krainc D. Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators. Journal of Medicinal Chemistry. PMID 27598312 DOI: 10.1021/acs.jmedchem.6b00930  1
2016 Li H, Wang HY, Kang S, Silverman RB, Poulos TL. Electrostatic control of isoform selective inhibitor binding in nitric oxide synthase. Biochemistry. PMID 27250740 DOI: 10.1021/acs.biochem.6b00261  1
2016 Xie CB, Haris Shaikh L, Garg S, Tanriver G, Teo AE, Zhou J, Maniero C, Zhao W, Kang S, Silverman RB, Azizan EA, Brown MJ. Regulation of aldosterone secretion by Cav1.3. Scientific Reports. 6: 24697. PMID 27098837 DOI: 10.1038/srep24697  0.56
2016 Wang HY, Qin Y, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-based Scaffold with a Pyridine Linker. Journal of Medicinal Chemistry. PMID 27050842 DOI: 10.1021/acs.jmedchem.6b00273  1
2016 Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB. Correction to Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. Journal of Medicinal Chemistry. PMID 26807481 DOI: 10.1021/acs.jmedchem.6b00036  0.72
2015 Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB. Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. Journal of Medicinal Chemistry. PMID 26469213 DOI: 10.1021/acs.jmedchem.5b01330  1
2015 Teixeira-Castro A, Jalles A, Esteves S, Kang S, da Silva Santos L, Silva-Fernandes A, Neto MF, Brielmann RM, Bessa C, Duarte-Silva S, Miranda A, Oliveira S, Neves-Carvalho A, Bessa J, Summavielle T, ... Silverman RB, et al. Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain : a Journal of Neurology. PMID 26373603 DOI: 10.1093/brain/awv262  1
2015 Zigmond E, Ya'acov AB, Lee H, Lichtenstein Y, Shalev Z, Smith Y, Zolotarov L, Ziv E, Kalman R, Le HV, Lu H, Silverman RB, Ilan Y. Suppression of Hepatocellular Carcinoma by Inhibition of Overexpressed Ornithine Aminotransferase. Acs Medicinal Chemistry Letters. 6: 840-844. PMID 26288681 DOI: 10.1021/acsmedchemlett.5b00153  1
2015 Zhang Y, Zhao KT, Fox SG, Kim J, Kirsch DR, Ferrante RJ, Morimoto RI, Silverman RB. Tertiary amine pyrazolones and their salts as inhibitors of mutant superoxide dismutase 1-dependent protein aggregation for the treatment of amyotrophic lateral sclerosis. Journal of Medicinal Chemistry. PMID 26186011 DOI: 10.1021/acs.jmedchem.5b00561  1
2015 Kang S, Li H, Tang W, Martásek P, Roman LJ, Poulos TL, Silverman RB. 2-Aminopyridines with a Truncated Side Chain to Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. Journal of Medicinal Chemistry. PMID 26120733 DOI: 10.1021/acs.jmedchem.5b00573  1
2015 Lee H, Le HV, Wu R, Doud E, Sanishvili R, Kellie JF, Compton PD, Pachaiyappan B, Liu D, Kelleher NL, Silverman RB. Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid. Acs Chemical Biology. PMID 26110556 DOI: 10.1021/acschembio.5b00212  1
2015 Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL. Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus. Chemistry & Biology. 22: 785-92. PMID 26091171 DOI: 10.1016/j.chembiol.2015.05.013  1
2015 Holden JK, Dejam D, Lewis MC, Huang H, Kang S, Jing Q, Xue F, Silverman RB, Poulos TL. Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase. Biochemistry. 54: 4075-82. PMID 26062720 DOI: 10.1021/acs.biochem.5b00431  1
2015 Khanfar MA, Quinti L, Wang H, Nobles J, Kazantsev AG, Silverman RB. Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors. Acs Medicinal Chemistry Letters. 6: 607-11. PMID 26005542 DOI: 10.1021/acsmedchemlett.5b00075  0.44
2015 Tang W, Li H, Doud EH, Chen Y, Choing S, Plaza C, Kelleher NL, Poulos TL, Silverman RB. Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid. Journal of the American Chemical Society. 137: 5980-9. PMID 25874809 DOI: 10.1021/jacs.5b01202  1
2015 Tang W, Li H, Poulos TL, Silverman RB. Mechanistic studies of inactivation of inducible nitric oxide synthase by amidines. Biochemistry. 54: 2530-8. PMID 25811913 DOI: 10.1021/acs.biochem.5b00135  1
2015 Le HV, Hawker DD, Wu R, Doud E, Widom J, Sanishvili R, Liu D, Kelleher NL, Silverman RB. Design and mechanism of tetrahydrothiophene-based γ-aminobutyric acid aminotransferase inactivators. Journal of the American Chemical Society. 137: 4525-33. PMID 25781189 DOI: 10.1021/jacs.5b01155  1
2015 Lee H, Doud EH, Wu R, Sanishvili R, Juncosa JI, Liu D, Kelleher NL, Silverman RB. Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115). Journal of the American Chemical Society. 137: 2628-40. PMID 25616005 DOI: 10.1021/ja512299n  1
2015 Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf NA, Wang H, Silverman RB, Ayata C, Maxwell MM, Steegborn C, Schwarzschild MA, Outeiro TF, Kazantsev AG. The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. Plos One. 10: e0116919. PMID 25608039 DOI: 10.1371/journal.pone.0116919  1
2015 Holden JK, Kang S, Hollingsworth SA, Li H, Lim N, Chen S, Huang H, Xue F, Tang W, Silverman RB, Poulos TL. Structure-based design of bacterial nitric oxide synthase inhibitors. Journal of Medicinal Chemistry. 58: 994-1004. PMID 25522110 DOI: 10.1021/jm501723p  1
2015 Mukherjee P, Li H, Sevrioukova I, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase. Journal of Medicinal Chemistry. 58: 1067-88. PMID 25489882 DOI: 10.1021/jm501719e  1
2015 Kang S, Watanabe M, Jacobs JC, Yamaguchi M, Dahesh S, Nizet V, Leyh TS, Silverman RB. Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability. European Journal of Medicinal Chemistry. 90: 448-61. PMID 25461893 DOI: 10.1016/j.ejmech.2014.11.040  1
2015 Lee H, Juncosa JI, Silverman RB. Ornithine aminotransferase versus GABA aminotransferase: implications for the design of new anticancer drugs. Medicinal Research Reviews. 35: 286-305. PMID 25145640 DOI: 10.1002/med.21328  0.48
2015 Khanfar MA, Quinti L, Wang H, Nobles J, Kazantsev AG, Silverman RB. Design and evaluation of 3-(benzylthio)benzamide derivatives as potent and selective SIRT2 inhibitors Acs Medicinal Chemistry Letters. 6: 607-611. DOI: 10.1021/acsmedchemlett.5b00075  1
2015 Lee H, Juncosa JI, Silverman RB. Ornithine aminotransferase versus GABA aminotransferase: Implications for the design of new anticancer drugs Medicinal Research Reviews. 35: 286-305. DOI: 10.1002/med.21328  1
2015 Silverman RB, Holladay MW. The Organic Chemistry of Drug Design and Drug Action: Third Edition The Organic Chemistry of Drug Design and Drug Action: Third Edition. 1-517.  1
2014 Ozdinler PH, Silverman RB. Treatment of amyotrophic lateral sclerosis: lessons learned from many failures. Acs Medicinal Chemistry Letters. 5: 1179-81. PMID 25408825 DOI: 10.1021/ml500404b  1
2014 Li H, Jamal J, Plaza C, Pineda SH, Chreifi G, Jing Q, Cinelli MA, Silverman RB, Poulos TL. Structures of human constitutive nitric oxide synthases. Acta Crystallographica. Section D, Biological Crystallography. 70: 2667-74. PMID 25286850 DOI: 10.1107/S1399004714017064  1
2014 Xia G, Benmohamed R, Morimoto RI, Kirsch DR, Silverman RB. Deuteration and fluorination of 1,3-bis(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione to improve its pharmacokinetic properties. Bioorganic & Medicinal Chemistry Letters. 24: 5098-101. PMID 25266783 DOI: 10.1016/j.bmcl.2014.08.066  1
2014 Davydov R, Labby KJ, Chobot SE, Lukoyanov DA, Crane BR, Silverman RB, Hoffman BM. Enzymatic and cryoreduction EPR studies of the hydroxylation of methylated N(ω)-hydroxy-L-arginine analogues by nitric oxide synthase from Geobacillus stearothermophilus. Biochemistry. 53: 6511-9. PMID 25251261 DOI: 10.1021/bi500485z  1
2014 Jing Q, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase. Bioorganic & Medicinal Chemistry Letters. 24: 4504-10. PMID 25149509 DOI: 10.1016/j.bmcl.2014.07.079  1
2014 Li H, Jamal J, Delker S, Plaza C, Ji H, Jing Q, Huang H, Kang S, Silverman RB, Poulos TL. The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases. Biochemistry. 53: 5272-9. PMID 25089924 DOI: 10.1021/bi500561h  1
2014 Trippier PC, Zhao KT, Fox SG, Schiefer IT, Benmohamed R, Moran J, Kirsch DR, Morimoto RI, Silverman RB. Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis. Acs Chemical Neuroscience. 5: 823-9. PMID 25001311 DOI: 10.1021/cn500147v  1
2014 Kang S, Tang W, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity Journal of Medicinal Chemistry. 57: 4382-4396. PMID 24758147 DOI: 10.1021/jm5004182  1
2014 Drury PP, Davidson JO, Mathai S, Van Den Heuij LG, Ji H, Bennet L, Tan S, Silverman RB, Gunn AJ. NNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep Neuropharmacology. 83: 62-70. PMID 24726307 DOI: 10.1016/j.neuropharm.2014.03.017  1
2014 Jing Q, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors. Acs Medicinal Chemistry Letters. 5: 56-60. PMID 24660051 DOI: 10.1021/ml400381s  1
2014 Khanfar MA, Quinti L, Wang H, Choi SH, Kazantsev AG, Silverman RB. Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors European Journal of Medicinal Chemistry. 76: 414-426. PMID 24602787 DOI: 10.1016/j.ejmech.2014.02.003  1
2014 Mukherjee P, Cinelli MA, Kang S, Silverman RB. Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain. Chemical Society Reviews. 43: 6814-38. PMID 24549364 DOI: 10.1039/c3cs60467e  1
2014 Cinelli MA, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition Journal of Medicinal Chemistry. 57: 1513-1530. PMID 24472039 DOI: 10.1021/jm401838x  1
2014 Huang H, Li H, Yang S, Chreifi G, Martásek P, Roman LJ, Meyskens FL, Poulos TL, Silverman RB. Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma Journal of Medicinal Chemistry. 57: 686-700. PMID 24447275 DOI: 10.1021/jm401252e  1
2013 Holden JK, Li H, Jing Q, Kang S, Richo J, Silverman RB, Poulos TL. Structural and biological studies on bacterial nitric oxide synthase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 110: 18127-31. PMID 24145412 DOI: 10.1073/pnas.1314080110  1
2013 Drury PP, Davidson JO, van den Heuij LG, Tan S, Silverman RB, Ji H, Blood AB, Fraser M, Bennet L, Gunn AJ. Partial neuroprotection by nNOS inhibition during profound asphyxia in preterm fetal sheep Experimental Neurology. 250: 282-292. PMID 24120436 DOI: 10.1016/j.expneurol.2013.10.003  1
2013 Walia A, Kang S, Silverman RB. Microwave-assisted protection of primary amines as 2,5-dimethylpyrroles and their orthogonal deprotection Journal of Organic Chemistry. 78: 10931-10937. PMID 24073706 DOI: 10.1021/jo401778e  1
2013 Jing Q, Li H, Chreifi G, Roman LJ, Martásek P, Poulos TL, Silverman RB. Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 5674-9. PMID 23993333 DOI: 10.1016/j.bmcl.2013.08.034  1
2013 Jing Q, Li H, Fang J, Roman LJ, Martásek P, Poulos TL, Silverman RB. In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures. Bioorganic & Medicinal Chemistry. 21: 5323-31. PMID 23867386 DOI: 10.1016/j.bmc.2013.06.014  1
2013 Juncosa JI, Lee H, Silverman RB. Two continuous coupled assays for ornithine-δ-aminotransferase Analytical Biochemistry. 440: 145-149. PMID 23747282 DOI: 10.1016/j.ab.2013.05.025  1
2013 Kang S, Cooper G, Dunne SF, Luan CH, James Surmeier D, Silverman RB. Antagonism of L-type Ca2+ channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics. Bioorganic & Medicinal Chemistry. 21: 4365-73. PMID 23688558 DOI: 10.1016/j.bmc.2013.04.054  1
2013 Kang S, Cooper G, Dunne SF, Luan CH, Surmeier DJ, Silverman RB. Structure-activity relationship of N,N'-disubstituted pyrimidinetriones as Ca(V)1.3 calcium channel-selective antagonists for Parkinson's disease. Journal of Medicinal Chemistry. 56: 4786-97. PMID 23651412 DOI: 10.1021/jm4005048  1
2013 Labby KJ, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. Methylated Nω-hydroxy-l-arginine analogues as mechanistic probes for the second step of the nitric oxide synthase-catalyzed reaction Biochemistry. 52: 3062-3073. PMID 23586781 DOI: 10.1021/bi301571v  1
2013 Huang H, Silverman RB. Recent advances toward improving the bioavailability of neuronal nitric oxide synthase inhibitors Current Topics in Medicinal Chemistry. 13: 803-812. PMID 23578024  1
2013 Trippier PC, Jansen Labby K, Hawker DD, Mataka JJ, Silverman RB. Target- and mechanism-based therapeutics for neurodegenerative diseases: Strength in numbers Journal of Medicinal Chemistry. 56: 3121-3147. PMID 23458846 DOI: 10.1021/jm3015926  1
2013 Huang H, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Structure-guided design of selective inhibitors of neuronal nitric oxide synthase Journal of Medicinal Chemistry. 56: 3024-3032. PMID 23451760 DOI: 10.1021/jm4000984  1
2013 Zhang Y, Benmohamed R, Huang H, Chen T, Voisine C, Morimoto RI, Kirsch DR, Silverman RB. Arylazanylpyrazolone derivatives as inhibitors of mutant superoxide dismutase 1 dependent protein aggregation for the treatment of amyotrophic lateral sclerosis. Journal of Medicinal Chemistry. 56: 2665-75. PMID 23445362 DOI: 10.1021/jm400079a  1
2013 Li H, Xue F, Kraus JM, Ji H, Labby KJ, Mataka J, Delker SL, Martásek P, Roman LJ, Poulos TL, Silverman RB. Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 21: 1333-1343. PMID 23352768 DOI: 10.1016/j.bmc.2012.12.019  1
2013 Zhang Y, Silverman RB. A novel synthesis of 1-aryl-3-piperidone derivatives. Tetrahedron Letters. 54: 573-575. PMID 23316094 DOI: 10.1016/j.tetlet.2012.11.085  1
2013 Juncosa JI, Groves AP, Xia G, Silverman RB. Probing the steric requirements of the γ-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin. Bioorganic & Medicinal Chemistry. 21: 903-11. PMID 23306054 DOI: 10.1016/j.bmc.2012.12.009  1
2013 Yang Z, Misner B, Ji H, Poulos TL, Silverman RB, Meyskens FL, Yang S. Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma Antioxidants and Redox Signaling. 19: 433-447. PMID 23199242 DOI: 10.1089/ars.2012.4563  1
2013 Zhang Y, Silverman RB. A novel synthesis of 1-aryl-3-piperidone derivatives Tetrahedron Letters. 54: 573-575. DOI: 10.1016/j.tetlet.2012.11.085  1
2012 Silverman RB, Candiotti KA, Gitlin MC. Tapentadol extended-release: a recent addition to our analgesic armamentarium. Pain Management. 2: 451-6. PMID 24645861 DOI: 10.2217/pmt.12.42  0.32
2012 Chopra V, Quinti L, Kim J, Vollor L, Narayanan KL, Edgerly C, Cipicchio PM, Lauver MA, Choi SH, Silverman RB, Ferrante RJ, Hersch S, Kazantsev AG. The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Reports. 2: 1492-7. PMID 23200855 DOI: 10.1016/j.celrep.2012.11.001  1
2012 Kang S, Cooper G, Dunne SF, Dusel B, Luan CH, Surmeier DJ, Silverman RB. CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease. Nature Communications. 3: 1146. PMID 23093183 DOI: 10.1038/ncomms2149  1
2012 Trippier PC, Benmohammed R, Kirsch DR, Silverman RB. Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1 Bioorganic and Medicinal Chemistry Letters. 22: 6647-6650. PMID 23021992 DOI: 10.1016/j.bmcl.2012.08.114  1
2012 Hawker DD, Silverman RB. Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase Bioorganic and Medicinal Chemistry. 20: 5763-5773. PMID 22944334 DOI: 10.1016/j.bmc.2012.08.009  1
2012 Zhang Y, Benmohamed R, Zhang W, Kim J, Edgerly CK, Zhu Y, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS. Acs Medicinal Chemistry Letters. 3: 584-587. PMID 22837812 DOI: 10.1021/ml3000963  1
2012 Drobyshevsky A, Yu L, Yang Y, Khalid S, Luo K, Jiang R, Ji H, Derrick M, Kay L, Silverman RB, Tan S. Antenatal insults modify newborn olfactory function by nitric oxide produced from neuronal nitric oxide synthase. Experimental Neurology. 237: 427-34. PMID 22836143 DOI: 10.1016/j.expneurol.2012.07.006  1
2012 Huang H, Ji H, Li H, Jing Q, Labby KJ, Martásek P, Roman LJ, Poulos TL, Silverman RB. Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations. Journal of the American Chemical Society. 134: 11559-72. PMID 22731813 DOI: 10.1021/ja302269r  1
2012 Ji H, Jing Q, Huang J, Silverman RB. Acid-Facilitated Debenzylation of N-Boc, N-Benzyl Double Protected 2-Aminopyridinomethylpyrrolidine Derivatives. Tetrahedron. 68: 1359-1366. PMID 22639474 DOI: 10.1016/j.tet.2011.12.013  1
2012 Choi SH, Quinti L, Kazantsev AG, Silverman RB. 3-(N-Arylsulfamoyl)benzamides, inhibitors of human sirtuin type 2 (SIRT2) Bioorganic and Medicinal Chemistry Letters. 22: 2789-2793. PMID 22446090 DOI: 10.1016/j.bmcl.2012.02.089  1
2012 Zhang Y, Silverman RB. Direct amination of γ-Halo-β-ketoesters with anilines Journal of Organic Chemistry. 77: 3462-3467. PMID 22390154 DOI: 10.1021/jo300239e  1
2012 Klaić L, Morimoto RI, Silverman RB. Celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets. Acs Chemical Biology. 7: 928-37. PMID 22380712 DOI: 10.1021/cb200539u  1
2012 Labby KJ, Xue F, Kraus JM, Ji H, Mataka J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 20: 2435-2443. PMID 22370337 DOI: 10.1016/j.bmc.2012.01.037  1
2012 Kraus JM, Gits HC, Silverman RB. High yielding allylation of a chiral secondary alcohol containing base sensitive functional groups. Tetrahedron Letters. 53: 1319-1322. PMID 22328795 DOI: 10.1016/j.tetlet.2011.12.120  0.32
2012 Chen T, Benmohamed R, Kim J, Smith K, Amante D, Morimoto RI, Kirsch DR, Ferrante RJ, Silverman RB. ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis. Journal of Medicinal Chemistry. 55: 515-27. PMID 22191331 DOI: 10.1021/jm2014277  1
2012 Zhang W, Benmohamed R, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells. Bioorganic & Medicinal Chemistry. 20: 1029-45. PMID 22189273 DOI: 10.1016/j.bmc.2011.11.039  1
2012 Silverman RB. The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1 S,3 S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile Spasms Journal of Medicinal Chemistry. 55: 567-575. PMID 22168767 DOI: 10.1021/jm201650r  1
2012 Pan Y, Gerasimov MR, Kvist T, Wellendorph P, Madsen KK, Pera E, Lee H, Schousboe A, Chebib M, Bräuner-Osborne H, Craft CM, Brodie JD, Schiffer WK, Dewey SL, Miller SR, ... Silverman RB, et al. (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction Journal of Medicinal Chemistry. 55: 357-366. PMID 22128851 DOI: 10.1021/jm201231w  1
2012 Kraus JM, Gits HC, Silverman RB. High yielding allylation of a chiral secondary alcohol containing base sensitive functional groups Tetrahedron Letters. 53: 1319-1322. DOI: 10.1016/j.tetlet.2011.12.120  1
2011 Klaić L, Trippier PC, Mishra RK, Morimoto RI, Silverman RB. Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol. Journal of the American Chemical Society. 133: 19634-7. PMID 22087583 DOI: 10.1021/ja208359a  1
2011 Gu W, Silverman RB. Synthesis of (S)-2-Boc-Amino-8-(R)-(tert-butyldimethylsilanyloxy) decanoic acid, a Precursor to the Unusual Amino Acid Residue of the Anticancer Agent Microsporin B. Tetrahedron Letters. 52: 5438-5440. PMID 21984850 DOI: 10.1016/j.tetlet.2011.07.132  0.68
2011 Watanabe M, Yamaguchi K, Tang W, Yoshida K, Silverman RB, Arisawa M, Shuto S. Synthesis of a series of 3,4-methanoarginines as side-chain conformationally restricted analogues of arginine Bioorganic and Medicinal Chemistry. 19: 5984-5988. PMID 21917467 DOI: 10.1016/j.bmc.2011.08.049  1
2011 Gu W, Silverman RB. Stereospecific total syntheses of proteasome inhibitors omuralide and lactacystin Journal of Organic Chemistry. 76: 8287-8293. PMID 21916437 DOI: 10.1021/jo201453x  1
2011 Xue F, Kraus JM, Labby KJ, Ji H, Mataka J, Xia G, Li H, Delker SL, Roman LJ, Martásek P, Poulos TL, Silverman RB. Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase Journal of Medicinal Chemistry. 54: 6399-6403. PMID 21809851 DOI: 10.1021/jm200411j  1
2011 Rao S, Lin Z, Drobyshevsky A, Chen L, Ji X, Ji H, Yang Y, Yu L, Derrick M, Silverman RB, Tan S. Involvement of neuronal nitric oxide synthase in ongoing fetal brain injury following near-term rabbit hypoxia-ischemia. Developmental Neuroscience. 33: 288-98. PMID 21757865 DOI: 10.1159/000327241  1
2011 Yu L, Derrick M, Ji H, Silverman RB, Whitsett J, Vásquez-Vivar J, Tan S. Neuronal nitric oxide synthase inhibition prevents cerebral palsy following hypoxia-ischemia in fetal rabbits: Comparison between JI-8 and 7-nitroindazole Developmental Neuroscience. 33: 312-319. PMID 21659718 DOI: 10.1159/000327244  1
2011 Doukov T, Li H, Sharma A, Martell JD, Soltis SM, Silverman RB, Poulos TL. Temperature-dependent spin crossover in neuronal nitric oxide synthase bound with the heme-coordinating thioether inhibitors. Journal of the American Chemical Society. 133: 8326-34. PMID 21534614 DOI: 10.1021/ja201466v  1
2011 Xue F, Fang J, Delker SL, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase Journal of Medicinal Chemistry. 54: 2039-2048. PMID 21410186 DOI: 10.1021/jm101071n  1
2011 Xia G, Benmohamed R, Kim J, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis. Journal of Medicinal Chemistry. 54: 2409-21. PMID 21375347 DOI: 10.1021/jm101549k  1
2011 Chen T, Benmohamed R, Arvanites AC, Ralay Ranaivo H, Morimoto RI, Ferrante RJ, Watterson DM, Kirsch DR, Silverman RB. Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis. Bioorganic & Medicinal Chemistry. 19: 613-22. PMID 21095130 DOI: 10.1016/j.bmc.2010.10.052  1
2011 Benmohamed R, Arvanites AC, Kim J, Ferrante RJ, Silverman RB, Morimoto RI, Kirsch DR. Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 12: 87-96. PMID 21073276 DOI: 10.3109/17482968.2010.522586  1
2011 Gu W, Silverman RB. Synthesis of (S)-2-Boc-Amino-8-(R)-(tert-butyldimethylsilanyloxy)decanoic acid, a precursor to the unusual amino acid residue of the anticancer agent microsporin B Tetrahedron Letters. 52: 5438-5440. DOI: 10.1016/j.tetlet.2011.07.132  1
2010 Delker SL, Xue F, Li H, Jamal J, Silverman RB, Poulos TL. Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase Biochemistry. 49: 10803-10810. PMID 21138269 DOI: 10.1021/bi1013479  1
2010 Liu D, Pozharski E, Fu M, Silverman RB, Ringe D. Mechanism of inactivation of escherichia coli aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid Biochemistry. 49: 10507-10515. PMID 21033689 DOI: 10.1021/bi101325z  1
2010 Ji H, Delker SL, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives Journal of Medicinal Chemistry. 53: 7804-7824. PMID 20958055 DOI: 10.1021/jm100947x  1
2010 Xue F, Li H, Delker SL, Fang J, Martásek P, Roman LJ, Poulos TL, Silverman RB. Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase Journal of the American Chemical Society. 132: 14229-14238. PMID 20843082 DOI: 10.1021/ja106175q  1
2010 Xue F, Li H, Fang J, Roman LJ, Martásek P, Poulos TL, Silverman RB. Peripheral but crucial: A hydrophobic pocket (Tyr706, Leu 337, and Met336) for potent and selective inhibition of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry Letters. 20: 6258-6261. PMID 20833542 DOI: 10.1016/j.bmcl.2010.08.096  1
2010 Xue F, Huang J, Ji H, Fang J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 18: 6526-6537. PMID 20673724 DOI: 10.1016/j.bmc.2010.06.074  1
2010 Xue F, Silverman RB. An Alkoxide Anion Triggered tert-Butyloxycarbonyl Group Migration. Mechanism and Application. Tetrahedron Letters. 51: 2536-2538. PMID 20414457 DOI: 10.1016/j.tetlet.2010.03.009  0.8
2010 Lefurgy ST, Rodriguez SB, Park CS, Cahill S, Silverman RB, Leyh TS. Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae. The Journal of Biological Chemistry. 285: 20654-63. PMID 20404339 DOI: 10.1074/jbc.M109.098350  1
2010 Chang CC, Cao S, Kang S, Kai L, Tian X, Pandey P, Dunne SF, Luan CH, Surmeier DJ, Silverman RB. Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2. Bioorganic & Medicinal Chemistry. 18: 3147-58. PMID 20382537 DOI: 10.1016/j.bmc.2010.03.038  1
2010 Delker SL, Ji H, Li H, Jamal J, Fang J, Xue F, Silverman RB, Poulos TL. Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model Journal of the American Chemical Society. 132: 5437-5442. PMID 20337441 DOI: 10.1021/ja910228a  1
2010 Lepore BW, Liu D, Peng Y, Fu M, Yasuda C, Manning JM, Silverman RB, Ringe D. Chiral discrimination among aminotransferases: Inactivation by 4-amino-4,5-dihydrothiophenecarboxylic Acid Biochemistry. 49: 3138-3147. PMID 20192272 DOI: 10.1021/bi902052x  1
2010 Heiferman MJ, Salabat MR, Ujiki MB, Strouch MJ, Cheon EC, Silverman RB, Bentrem DJ. Sansalvamide induces pancreatic cancer growth arrest through changes in the cell cycle Anticancer Research. 30: 73-78. PMID 20150619  1
2010 Kudoh T, Park CS, Lefurgy ST, Sun M, Michels T, Leyh TS, Silverman RB. Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae Bioorganic and Medicinal Chemistry. 18: 1124-1134. PMID 20056424 DOI: 10.1016/j.bmc.2009.12.050  1
2010 Martell JD, Li H, Doukov T, Martásek P, Roman LJ, Soltis M, Poulos TL, Silverman RB. Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency. Journal of the American Chemical Society. 132: 798-806. PMID 20014790 DOI: 10.1021/ja908544f  1
2010 Xue F, Fang J, Lewis WW, Martásek P, Roman LJ, Silverman RB. Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability Bioorganic and Medicinal Chemistry Letters. 20: 554-557. PMID 19963381 DOI: 10.1016/j.bmcl.2009.11.086  1
2010 Xue F, Silverman RB. An alkoxide anion-triggered tert-butyloxycarbonyl group migration. Mechanism and application Tetrahedron Letters. 51: 2536-2538. DOI: 10.1016/j.tetlet.2010.03.009  1
2009 Xue F, Gu W, Silverman RB. Concise route to the chiral pyrrolidine core of selective inhibitors of neuronal nitric oxide Organic Letters. 11: 5194-5197. PMID 19860389 DOI: 10.1021/ol902109t  1
2009 Silverman RB, Lawton GR, Ranaivo HR, Chico LK, Seo J, Watterson DM. Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration Bioorganic and Medicinal Chemistry. 17: 7593-7603. PMID 19796958 DOI: 10.1016/j.bmc.2009.08.065  1
2009 Lawton GR, Ji H, Martásek P, Roman LJ, Silverman RB. Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase. Beilstein Journal of Organic Chemistry. 5: 28. PMID 19590740 DOI: 10.3762/bjoc.5.28  1
2009 Derrick M, Drobyshevsky A, Ji X, Chen L, Yang Y, Ji H, Silverman RB, Tan S. Hypoxia-ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 27: 549-57. PMID 19573586 DOI: 10.1016/j.ijdevneu.2009.06.008  1
2009 Fang J, Ji H, Lawton GR, Xue F, Roman LJ, Silverman RB. L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors Journal of Medicinal Chemistry. 52: 4533-4537. PMID 19537690 DOI: 10.1021/jm900380j  1
2009 Fang J, Silverman RB. A cellular model for screening neuronal nitric oxide synthase inhibitors Analytical Biochemistry. 390: 74-78. PMID 19362065 DOI: 10.1016/j.ab.2009.04.004  1
2009 Igarashi J, Li H, Jamal J, Ji H, Fang J, Lawton GR, Silverman RB, Poulos TL. Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors. Journal of Medicinal Chemistry. 52: 2060-6. PMID 19296678 DOI: 10.1021/jm900007a  1
2009 Lawton GR, Ralay Ranaivo H, Chico LK, Ji H, Xue F, Martásek P, Roman LJ, Watterson DM, Silverman RB. Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability. Bioorganic & Medicinal Chemistry. 17: 2371-80. PMID 19268602 DOI: 10.1016/j.bmc.2009.02.017  1
2009 Ji H, Tan S, Igarashi J, Li H, Derrick M, Martásek P, Roman LJ, Vásquez-Vivar J, Poulos TL, Silverman RB. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Annals of Neurology. 65: 209-17. PMID 19235180 DOI: 10.1002/ana.21555  1
2009 Silverman RB. Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases. Accounts of Chemical Research. 42: 439-51. PMID 19154146 DOI: 10.1021/ar800201v  1
2009 Ji H, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping. Journal of Medicinal Chemistry. 52: 779-97. PMID 19125620 DOI: 10.1021/jm801220a  1
2008 Ji H, Stanton BZ, Igarashi J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors. Journal of the American Chemical Society. 130: 3900-14. PMID 18321097 DOI: 10.1021/ja0772041  1
2008 Silverman RB. From basic science to blockbuster drug: the discovery of Lyrica. Angewandte Chemie (International Ed. in English). 47: 3500-4. PMID 18307181 DOI: 10.1002/anie.200704280  1
2008 Zhu Y, Silverman RB. Revisiting heme mechanisms. A perspective on the mechanisms of nitric oxide synthase (NOS), Heme oxygenase (HO), and cytochrome P450s (CYP450s). Biochemistry. 47: 2231-43. PMID 18237198 DOI: 10.1021/bi7023817  1
2008 Trott A, West JD, Klai? L, Westerheide SD, Silverman RB, Morimoto RI, Morano KA. Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Molecular Biology of the Cell. 19: 1104-12. PMID 18199679 DOI: 10.1091/mbc.E07-10-1004  1
2008 Clift MD, Silverman RB. Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase Bioorganic and Medicinal Chemistry Letters. 18: 3122-3125. PMID 17988865 DOI: 10.1016/j.bmcl.2007.10.060  1
2007 Clift MD, Ji H, Deniau GP, O'Hagan D, Silverman RB. Enantiomers of 4-amino-3-fluorobutanoic acid as substrates for γ-aminobutyric acid aminotransferase. Conformational probes for GABA binding Biochemistry. 46: 13819-13828. PMID 17988152 DOI: 10.1021/bi701249q  1
2007 Liu D, Pozharski E, Lepore BW, Fu M, Silverman RB, Petsko GA, Ringe D. Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms". Biochemistry. 46: 10517-27. PMID 17713924 DOI: 10.1021/bi700663n  1
2007 Erdal EP, Martásek P, Roman LJ, Silverman RB. Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry. 15: 6096-108. PMID 17614291 DOI: 10.1016/j.bmc.2007.06.038  1
2007 Seo J, Igarashi J, Li H, Martasek P, Roman LJ, Poulos TL, Silverman RB. Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water. Journal of Medicinal Chemistry. 50: 2089-99. PMID 17425297 DOI: 10.1021/jm061305c  1
2007 Zhu Y, Silverman RB. Model studies for heme oxygenase-catalyzed porphyrin meso hydroxylation. Organic Letters. 9: 1195-8. PMID 17343390 DOI: 10.1021/ol063088f  1
2007 Yuan H, Silverman RB. Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase. Bioorganic & Medicinal Chemistry Letters. 17: 1651-4. PMID 17267220 DOI: 10.1016/j.bmcl.2006.12.119  1
2007 Seo J, Martásek P, Roman LJ, Silverman RB. Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry. 15: 1928-38. PMID 17239601 DOI: 10.1016/j.bmc.2007.01.001  1
2007 Zhu Y, Silverman RB. Electronic effects of peripheral substituents at porphyrin meso positions. The Journal of Organic Chemistry. 72: 233-9. PMID 17194104 DOI: 10.1021/jo061951j  1
2007 Gu W, Cueto M, Jensen PR, Fenical W, Silverman RB. Microsporins A and B: new histone deacetylase inhibitors from the marine-derived fungus Microsporum cf. gypseum and the solid-phase synthesis of microsporin A Tetrahedron. 63: 6535-6541. DOI: 10.1016/j.tet.2007.04.025  1
2006 Lu H, Silverman RB. Fluorinated conformationally restricted gamma-aminobutyric acid aminotransferase inhibitors. Journal of Medicinal Chemistry. 49: 7404-12. PMID 17149870 DOI: 10.1021/jm0608715  1
2006 Wang Z, Yuan H, Nikolic D, Van Breemen RB, Silverman RB. (+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway. Biochemistry. 45: 14513-22. PMID 17128990 DOI: 10.1021/bi061592m  1
2006 Ji H, Gómez-Vidal JA, Martasek P, Roman LJ, Silverman RB. Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors. Journal of Medicinal Chemistry. 49: 6254-63. PMID 17034131 DOI: 10.1021/jm0604124  1
2006 Mbadugha BN, Seo J, Ji H, Martásek P, Roman LJ, Shea TM, Li H, Poulos TL, Silverman RB. Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase. Bioorganic & Medicinal Chemistry. 14: 3681-90. PMID 16480878 DOI: 10.1016/j.bmc.2006.01.044  1
2006 Gu W, Nusinzon I, Smith RD, Horvath CM, Silverman RB. Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases. Bioorganic & Medicinal Chemistry. 14: 3320-9. PMID 16434199 DOI: 10.1016/j.bmc.2005.12.047  1
2006 Litzinger EA, Martásek P, Roman LJ, Silverman RB. Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry. 14: 3185-98. PMID 16431112 DOI: 10.1016/j.bmc.2005.12.043  1
2006 Ujiki MB, Milam B, Ding XZ, Roginsky AB, Salabat MR, Talamonti MS, Bell RH, Gu W, Silverman RB, Adrian TE. A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest. Biochemical and Biophysical Research Communications. 340: 1224-8. PMID 16414351 DOI: 10.1016/j.bbrc.2005.12.131  1
2006 Wang Z, Silverman RB. Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase. Bioorganic & Medicinal Chemistry. 14: 2242-52. PMID 16314106 DOI: 10.1016/j.bmc.2005.11.010  1
2006 Yuan H, Silverman RB. New substrates and inhibitors of gamma-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: design, synthesis, and biological activity. Bioorganic & Medicinal Chemistry. 14: 1331-8. PMID 16263300 DOI: 10.1016/j.bmc.2005.09.067  1
2006 Crittenden DL, Park A, Qiu J, Silverman RB, Duke RK, Johnston GA, Jordan MJ, Chebib M. Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. Bioorganic & Medicinal Chemistry. 14: 447-55. PMID 16183289 DOI: 10.1016/j.bmc.2005.08.037  1
2006 Lawton GR, Ji H, Silverman RB. Remote protection prevents unwanted cyclizations with 2-aminopyridines Tetrahedron Letters. 47: 6113-6115. DOI: 10.1016/j.tetlet.2006.06.091  1
2006 Seo J, Silverman RB. Synthesis of arginine-containing hydroxamate dipeptidomimetics Tetrahedron Letters. 47: 4069-4073. DOI: 10.1016/j.tetlet.2006.03.190  1
2005 Li H, Flinspach ML, Igarashi J, Jamal J, Yang W, Gómez-Vidal JA, Litzinger EA, Huang H, Erdal EP, Silverman RB, Poulos TL. Exploring the binding conformations of bulkier dipeptide amide inhibitors in constitutive nitric oxide synthases. Biochemistry. 44: 15222-9. PMID 16285725 DOI: 10.1021/bi0513610  1
2005 Erdal EP, Litzinger EA, Seo J, Zhu Y, Ji H, Silverman RB. Selective neuronal nitric oxide synthase inhibitors. Current Topics in Medicinal Chemistry. 5: 603-24. PMID 16101423 DOI: 10.2174/1568026054679317  1
2005 Liu S, Gu W, Lo D, Ding XZ, Ujiki M, Adrian TE, Soff GA, Silverman RB. N-methylsansalvamide a peptide analogues. Potent new antitumor agents. Journal of Medicinal Chemistry. 48: 3630-8. PMID 15887970 DOI: 10.1021/jm048952t  1
2005 Vintém AP, Price NT, Silverman RB, Ramsay RR. Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines. Bioorganic & Medicinal Chemistry. 13: 3487-95. PMID 15848762 DOI: 10.1016/j.bmc.2005.02.061  1
2005 Zhu Y, Nikolic D, Van Breemen RB, Silverman RB. Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification. Journal of the American Chemical Society. 127: 858-68. PMID 15656623 DOI: 10.1021/ja0445645  1
2004 Wang Z, Silverman RB. Synthesis of cyclopropane isosteres of the antiepilepsy drug vigabatrin and evaluation of their inhibition of GABA aminotransferase. Journal of Enzyme Inhibition and Medicinal Chemistry. 19: 293-301. PMID 15558944  1
2004 Storici P, Qiu J, Schirmer T, Silverman RB. Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography. Biochemistry. 43: 14057-63. PMID 15518554 DOI: 10.1021/bi0487185  1
2004 Westerheide SD, Bosman JD, Mbadugha BN, Kawahara TL, Matsumoto G, Kim S, Gu W, Devlin JP, Silverman RB, Morimoto RI. Celastrols as inducers of the heat shock response and cytoprotection. The Journal of Biological Chemistry. 279: 56053-60. PMID 15509580 DOI: 10.1074/jbc.M409267200  1
2004 Pan Y, Calvert K, Silverman RB. Conformationally-restricted vigabatrin analogs as irreversible and reversible inhibitors of gamma-aminobutyric acid aminotransferase. Bioorganic & Medicinal Chemistry. 12: 5719-25. PMID 15465348 DOI: 10.1016/j.bmc.2004.07.065  1
2004 Schering CA, Zhong B, Woo JC, Silverman RB. Poly(ethylene glycol)-supported enzyme inactivators. Efficient identification of the site of covalent attachment to alpha-chymotrypsin by PEG-TPCK. Bioconjugate Chemistry. 15: 673-6. PMID 15264852 DOI: 10.1021/bc049940p  1
2004 Flinspach M, Li H, Jamal J, Yang W, Huang H, Silverman RB, Poulos TL. Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound. Biochemistry. 43: 5181-7. PMID 15122883 DOI: 10.1021/bi0361867  1
2004 Gómez-Vidal JA, Martásek P, Roman LJ, Silverman RB. Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors. Journal of Medicinal Chemistry. 47: 703-10. PMID 14736250 DOI: 10.1021/jm030297m  1
2004 Flinspach ML, Li H, Jamal J, Yang W, Huang H, Hah JM, Gómez-Vidal JA, Litzinger EA, Silverman RB, Poulos TL. Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase. Nature Structural & Molecular Biology. 11: 54-9. PMID 14718923 DOI: 10.1038/nsmb704  1
2004 Fu M, Silverman RB. Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism. Bioorganic & Medicinal Chemistry Letters. 14: 203-6. PMID 14684328 DOI: 10.1016/j.bmcl.2003.09.065  1
2004 Storici P, De Biase D, Bossa F, Bruno S, Mozzarelli A, Peneff C, Silverman RB, Schirmer T. Structures of γ-Aminobutyric Acid (GABA) Aminotransferase, a Pyridoxal 5′-Phosphate, and [2Fe-2S] Cluster-containing Enzyme, Complexed with γ-Ethynyl-GABA and with the Antiepilepsy Drug Vigabatrin Journal of Biological Chemistry. 279: 363-373. PMID 14534310 DOI: 10.1074/jbc.M305884200  1
2004 Silverman RB. The Organic Chemistry of Drug Design and Drug Action: Second Edition The Organic Chemistry of Drug Design and Drug Action: Second Edition. 1-617.  1
2003 Ji H, Li H, Flinspach M, Poulos TL, Silverman RB. Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors. Journal of Medicinal Chemistry. 46: 5700-11. PMID 14667223 DOI: 10.1021/jm030301u  1
2003 Pan Y, Qiu J, Silverman RB. Design, synthesis, and biological activity of a difluoro-substituted, conformationally rigid vigabatrin analogue as a potent gamma-aminobutyric acid aminotransferase inhibitor. Journal of Medicinal Chemistry. 46: 5292-3. PMID 14640537 DOI: 10.1021/jm034162s  1
2003 Gu W, Silverman RB. Solid-Phase Total Synthesis of Scytalidamide A Journal of Organic Chemistry. 68: 8774-8779. PMID 14604343 DOI: 10.1021/jo0346712  1
2003 Lu X, Nikolic D, Mitchell DJ, van Breemen RB, Mersfelder JA, Hille R, Silverman RB. A mechanism for substrate-Induced formation of 6-hydroxyflavin mononucleotide catalyzed by C30A trimethylamine dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 13: 4129-32. PMID 14592522 DOI: 10.1016/j.bmcl.2003.07.032  1
2003 Lu X, Rodríguez M, Gu W, Silverman RB. Inactivation of mitochondrial monoamine oxidase B by methylthio-substituted benzylamines Bioorganic and Medicinal Chemistry. 11: 4423-4430. PMID 13129579 DOI: 10.1016/S0968-0896(03)00486-3  1
2003 Hah JM, Martásek P, Roman LJ, Silverman RB. Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Journal of Medicinal Chemistry. 46: 1661-9. PMID 12699384 DOI: 10.1021/jm0202932  1
2003 Nandi D, Lightcap ES, Koo YK, Lu X, Quancard J, Silverman RB. Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver International Journal of Biochemistry and Cell Biology. 35: 1085-1097. PMID 12672479 DOI: 10.1016/S1357-2725(02)00347-3  1
2003 Gu W, Silverman RB. New stable backbone linker resins for solid-phase peptide synthesis Organic Letters. 5: 415-418. PMID 12583732 DOI: 10.1021/ol027212g  1
2002 Gu W, Liu S, Silverman RB. Solid-phase, Pd-catalyzed silicon-aryl carbon bond formation. Synthesis of sansalvamide A peptide Organic Letters. 4: 4171-4174. PMID 12423114 DOI: 10.1021/ol0269392  1
2002 Lee Y, Ling KQ, Lu X, Silverman RB, Shepard EM, Dooley DM, Sayre LM. 3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases. Journal of the American Chemical Society. 124: 12135-43. PMID 12371853 DOI: 10.1021/ja0205434  1
2002 Choi S, Silverman RB. Inactivation and inhibition of γ-aminobutyric acid aminotransferase by conformationally restricted vigabatrin analogues Journal of Medicinal Chemistry. 45: 4531-4539. PMID 12238932 DOI: 10.1021/jm020134i  1
2002 Choi S, Storici P, Schirmer T, Silverman RB. Design of a conformationally restricted analogue of the antiepilepsy drug vigabatrin that directs its mechanism of inactivation of γ-aminobutyric acid aminotransferase Journal of the American Chemical Society. 124: 1620-1624. PMID 11853435 DOI: 10.1021/ja011968d  1
2001 Huang H, Martásek P, Roman LJ, Silverman RB. Synthesis and evaluation of dipeptide amides containing N omega-nitroarginine and D-2,4-diaminobutyric acids as inhibitors of neuronal nitric oxide synthase. Journal of Enzyme Inhibition. 16: 233-9. PMID 11697043  1
2001 Gómez-Vidal JA, Silverman RB. Short, highly efficient syntheses of protected 3-azido- and 4-azidoproline and their precursors Organic Letters. 3: 2481-2484. PMID 11483040 DOI: 10.1021/ol0161054  1
2001 Gómez-Vidal JA, Forrester MT, Silverman RB. Mild and selective sodium azide mediated cleavage of p-nitrobenzoic esters Organic Letters. 3: 2477-2479. PMID 11483039 DOI: 10.1021/ol016104b  1
2001 Hah JM, Roman LJ, Martásek P, Silverman RB. Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. Journal of Medicinal Chemistry. 44: 2667-70. PMID 11472219 DOI: 10.1021/jm0101491  1
2001 Huang H, Hah JM, Silverman RB. Mechanism of nitric oxide synthase. Evidence that direct hydrogen atom abstraction from the O-H bond of NG-hydroxyarginine is not relevant to the mechanism. Journal of the American Chemical Society. 123: 2674-6. PMID 11456942 DOI: 10.1021/ja005900u  1
2001 Mitchell DJ, Nikolic D, Jang MH, van Breemen RB, Hille R, Silverman RB. Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-alpha-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine. Biochemistry. 40: 8523-30. PMID 11456490 DOI: 10.1021/bi0105126  1
2001 Mitchell DJ, Nikolic D, van Breemen RB, Silverman RB. Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: mass spectral evidence for the flavin adduct. Bioorganic & Medicinal Chemistry Letters. 11: 1757-60. PMID 11425554 DOI: 10.1016/S0960-894X(01)00302-X  1
2001 Mitchell DJ, Nikolic D, Rivera E, Sablin SO, Choi S, van Breemen RB, Singer TP, Silverman RB. Spectrometric evidence for the flavin-1-phenylcyclopropylamine inactivator adduct with monoamine oxidase N. Biochemistry. 40: 5447-56. PMID 11331009 DOI: 10.1021/bi010388q  1
2001 Lee Y, Silverman RB. Silicon-based aromatic transferring linkers for traceless solid-phase synthesis of aryl-, polyaryl-, and heteroaryl-containing compounds Tetrahedron. 57: 5339-5352. DOI: 10.1016/S0040-4020(01)00457-4  1
2001 Woodroofe CC, Zhong B, Lu X, Silverman RB. Anomalous Schmidt reaction products of phenylacetic acid and derivatives Journal of the Chemical Society. Perkin Transactions 2. 55-59.  1
2001 Woodroofe CC, Zhong B, Lu X, Silverman RB. Anomalous Schmidt reaction products of phenylacetic acid and derivatives Journal of the Chemical Society. Perkin Transactions 2. 55-59.  1
2000 Lee Y, Martásek P, Roman LJ, Silverman RB. 1H-Pyrazole-1-carboxamidines: New inhibitors of nitric oxide synthase Bioorganic and Medicinal Chemistry Letters. 10: 2771-2774. PMID 11133088  1
2000 Lee Y, Silverman RB. Rapid, high-yield, solid-phase synthesis of the antitumor antibiotic sansalvamide a using a side-chain-tethered phenylalanine building block Organic Letters. 2: 3743-3746. PMID 11073690  1
2000 Hah JM, Roman LJ, Silverman RB. Deuterium isotope effects and product studies for the oxidation of N(omega)-allyl-L-arginine and N(omega)-allyl-N(omega)-hydroxy-L-arginine by neuronal nitric oxide synthase. Bioorganic & Medicinal Chemistry. 8: 1931-6. PMID 11003138 DOI: 10.1016/S0968-0896(00)00154-1  1
2000 Wang X, Silverman RB. Monoamine oxidase-catalyzed oxidation of endo,endo-2-amino-6-[(Z)-2'-phenyl]ethenylbicyclo[2.2.1]heptane, a potential probe for a radical cation intermediate Bioorganic and Medicinal Chemistry. 8: 1645-1651. PMID 10976512 DOI: 10.1016/S0968-0896(00)00094-8  1
2000 Huang H, Martásek P, Roman LJ, Silverman RB. Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases. Journal of Medicinal Chemistry. 43: 2938-45. PMID 10956202 DOI: 10.1021/jm000127z  1
2000 Woodroofe CC, Mostashari R, Lu X, Ramsay RR, Silverman RB. Selective inhibition of monoamine oxidase B by aminoethyl substituted benzyl ethers. Journal of Enzyme Inhibition. 15: 11-21. PMID 10850952  1
2000 Lee Y, Silverman RB. Traceless solid-phase synthesis of chiral 3-aryl β-amino acid containing peptides using a side-chain-tethered β-amino acid building block Organic Letters. 2: 303-306. PMID 10814308  1
2000 Qiu J, Silverman RB. A new class of conformationally rigid analogues of 4-amino-5- halopentanoic acids, potent inactivators of γ-aminobutyric acid aminotransferase Journal of Medicinal Chemistry. 43: 706-720. PMID 10691696 DOI: 10.1021/jm9904755  1
2000 Koo YK, Nandi D, Silverman RB. The multiple active enzyme species of γ-aminobutyric acid aminotransferase are not isozymes Archives of Biochemistry and Biophysics. 374: 248-254. PMID 10666304 DOI: 10.1006/abbi.1999.1623  1
2000 Tierney DL, Huang H, Martásek P, Roman LJ, Silverman RB, Hoffman BM. ENDOR spectroscopic evidence for the geometry of binding of retro-inverso-N(ω)-nitroarginine-containing dipeptide amides to neuronal nitric oxide synthase Journal of the American Chemical Society. 122: 7869-7875. DOI: 10.1021/ja993927b  1
2000 Tierney DL, Huang H, Martásek P, Roman LJ, Silverman RB, Masters BSS, Hoffman BM. ENDOR studies of L-arginine and N(G)-hydroxy-L-arginine bound to all three holo-nitric oxide synthase isozymes [10] Journal of the American Chemical Society. 122: 5405-5406. DOI: 10.1021/ja993685f  1
2000 Tantillo DJ, Fukuto JM, Hoffman BM, Silverman RB, Houk KN. Theoretical studies on N(g)-hydroxy-L-arginine and derived radicals: Implications for the mechanism of nitric oxide synthase Journal of the American Chemical Society. 122: 536-537. DOI: 10.1021/ja991876c  1
1999 Qiu J, Pingsterhaus JM, Silverman RB. Inhibition and substrate activity of conformationally rigid vigabatrin analogues with γ-aminobutyric acid aminotransferase Journal of Medicinal Chemistry. 42: 4725-4728. PMID 10579835 DOI: 10.1021/jm990271o  1
1999 Chebib M, Johnston GA, Mattsson JP, Rydström K, Nilsson K, Qiu J, Stevenson SH, Silverman RB. Aminomethyl-2,6-difluorophenols as a novel class of increased lipophilicity GABA(C) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 9: 3093-8. PMID 10560731 DOI: 10.1016/S0960-894X(99)00542-9  1
1999 Lee Y, Martasek P, Roman LJ, Masters BSS, Silverman RB. Imidazole-containing amino acids as selective inhibitors of nitric oxide synthases Bioorganic and Medicinal Chemistry. 7: 1941-1951. PMID 10530943 DOI: 10.1016/S0968-0896(99)00117-0  1
1999 Fu M, Silverman RB. Isolation and characterization of the product of inactivation of γ-aminobutyric acid aminotransferase by gabaculine Bioorganic and Medicinal Chemistry. 7: 1581-1590. PMID 10482450 DOI: 10.1016/S0968-0896(99)00081-4  1
1999 Huang H, Martasek P, Roman LJ, Masters BS, Silverman RB. N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase. Journal of Medicinal Chemistry. 42: 3147-53. PMID 10447959 DOI: 10.1021/jm990111c  1
1999 Tierney DL, Huang H, Martasek P, Masters BS, Silverman RB, Hoffman BM. ENDOR spectroscopic evidence for the position and structure of NG-hydroxy-L-arginine bound to holo-neuronal nitric oxide synthase. Biochemistry. 38: 3704-10. PMID 10090758 DOI: 10.1021/bi982904r  1
1999 Lee Y, Silverman RB. Efficient solid-phase synthesis of compounds containing phenylalanine and its derivatives via side-chain attachment to the polymer support Journal of the American Chemical Society. 121: 8407-8408. DOI: 10.1021/ja991679d  1
1999 Fu M, Nikolic D, Van Breemen RB, Silverman RB. Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid Journal of the American Chemical Society. 121: 7751-7759. DOI: 10.1021/ja9915551  1
1998 Wang X, Silverman RB. 2-(Iodoethenyl)benzylamines as Potential Probes for Radical Intermediates Formed during Monoamine Oxidase Catalyzed Oxidations. The Journal of Organic Chemistry. 63: 7357-7363. PMID 11672383  1
1997 Silverman RB, Huang H, Marletta MA, Martasek P. Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters. Journal of Medicinal Chemistry. 40: 2813-7. PMID 9288162 DOI: 10.1021/jm970200u  1
1976 Silverman RB, Dolphin D. Model studies for coenzyme B12 dependent enzyme-catalyzed rearrangements. Kinetics and mechanism of decomposition of formylmethylcobalamin and its acetals. Journal of the American Chemical Society. 98: 4633-9. PMID 932368  1
1976 Silverman RB, Dolphin D. Model studies for coenzyme B12 dependent enzyme-catalyzed rearrangements. Evidence for cobalt(III)-olefin pi complexes. Journal of the American Chemical Society. 98: 4626-33. PMID 932367  1
1974 Silverman RB, Dolphin D. Letter: Reactions of vinyl ethers with cobalamins and cobaloximes. Journal of the American Chemical Society. 96: 7094-6. PMID 4474189  1
1974 Silverman RB, Dolphin D, Carty TJ, Krodel EK, Abeles RH. Letter: Formylmethylcobalamin. Journal of the American Chemical Society. 96: 7096-7. PMID 4436511  1
1973 Silverman RB, Dolphin D. A direct method for cobalt-carbon bond formation in cobalt(3)-containing cobalamins and cobaloximes. Further support for cobalt(3). Complexes in coenzyme B 12 dependent rearrangements. Journal of the American Chemical Society. 95: 1686-8. PMID 4689333  1
1972 Silverman RB, Dolphin D, Babior BM. A model for the mechanism of action of coenzyme B 12 dependent enzymes. Evidence for sigma leads to pi rearrangements in cobaloximes. Journal of the American Chemical Society. 94: 4028-32. PMID 5037991  1
Show low-probability matches.