Gary Herbert Posner - Publications

Affiliations: 
2016 Johns Hopkins University, Baltimore, MD 
Area:
Medicinal, Organic and Organometallic Chemistry
Website:
http://chemistry.jhu.edu/Posner/biography.html

210 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Fox JM, Moynihan JR, Mott BT, Mazzone JR, Anders NM, Brown PA, Rudek MA, Liu JO, Arav-Boger R, Posner GH, Civin CI, Chen X. Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs. Oncotarget. PMID 26771236 DOI: 10.18632/oncotarget.6896  1
2015 Roy S, He R, Kapoor A, Forman M, Mazzone JR, Posner GH, Arav-Boger R. Inhibition of Human Cytomegalovirus Replication by Artemisinins: Effects Mediated through Cell Cycle Modulation. Antimicrobial Agents and Chemotherapy. 59: 3870-9. PMID 25870074 DOI: 10.1128/AAC.00262-15  1
2015 Conyers RC, Mazzone JR, Tripathi AK, Sullivan DJ, Posner GH. Antimalarial chemotherapy: orally curative artemisinin-derived trioxane dimer esters. Bioorganic & Medicinal Chemistry Letters. 25: 245-8. PMID 25481079 DOI: 10.1016/j.bmcl.2014.11.064  1
2014 Mazzone JR, Conyers RC, Tripathi AK, Sullivan DJ, Posner GH. Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates. Bioorganic & Medicinal Chemistry Letters. 24: 2440-3. PMID 24775306 DOI: 10.1016/j.bmcl.2014.04.025  1
2014 Schultz TL, Hencken CP, Woodard LE, Posner GH, Yolken RH, Jones-Brando L, Carruthers VB. A thiazole derivative of artemisinin moderately reduces Toxoplasma gondii cyst burden in infected mice. The Journal of Parasitology. 100: 516-21. PMID 24524228 DOI: 10.1645/13-451.1  1
2014 Conyers RC, Mazzone JR, Siegler MA, Tripathi AK, Sullivan DJ, Mott BT, Posner GH. The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether. Bioorganic & Medicinal Chemistry Letters. 24: 1285-9. PMID 24508128 DOI: 10.1016/j.bmcl.2014.01.059  1
2014 Cai H, Kapoor A, He R, Venkatadri R, Forman M, Posner GH, Arav-Boger R. In vitro combination of anti-cytomegalovirus compounds acting through different targets: Role of the slope parameter and insights into mechanisms of action Antimicrobial Agents and Chemotherapy. 58: 986-994. PMID 24277030 DOI: 10.1128/AAC.01972-13  1
2014 Somjen D, Katzburg S, Hendel D, Sharon O, Posner GH. Age-and sex-dependent hormonal modulation of the expression of vitamin D receptor and 25-hydroxyvitamin D 1α hydroxylase in human bone cells Expert Review of Endocrinology and Metabolism. 9: 283-292. DOI: 10.1586/17446651.2014.899897  1
2014 Somjen D, Katzburg S, Sharon O, Hendel D, Posner GH. Mutual modulation of femarelle and vitamin D analog activities in human derived female cultured osteoblasts Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 14: 162-170.  1
2013 He R, Forman M, Mott BT, Venkatadri R, Posner GH, Arav-Boger R. Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety Antimicrobial Agents and Chemotherapy. 57: 4208-4214. PMID 23774439 DOI: 10.1128/AAC.00893-13  1
2013 Mott BT, He R, Chen X, Fox JM, Civin CI, Arav-Boger R, Posner GH. Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study. Bioorganic & Medicinal Chemistry. 21: 3702-7. PMID 23673218 DOI: 10.1016/j.bmc.2013.04.027  1
2013 Somjen D, Katzburg S, Kaye AM, Posner GH. Age-dependent responsiveness of human female bone cells to vitamin D analog and PTH Journal of Endocrinological Investigation. 36: 118-122. PMID 23481611  1
2013 Mott BT, Tripathi A, Siegler MA, Moore CD, Sullivan DJ, Posner GH. Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs. Journal of Medicinal Chemistry. 56: 2630-41. PMID 23425037 DOI: 10.1021/jm400058j  1
2013 Somjen D, Grafi-Cohen M, Posner GH, Sharon O, Kraiem Z, Stern N. Vitamin D less-calcemic analog modulates the expression of estrogen receptors, vitamin D receptor and 1α-hydroxylase 25-hydroxy vitamin D in human thyroid cancer cell lines Journal of Steroid Biochemistry and Molecular Biology. 136: 80-82. PMID 23059472 DOI: 10.1016/j.jsbmb.2012.09.015  1
2013 Slack RD, Siegler MA, Posner GH. Highly stereocontrolled and regiocontrolled syntheses of polyoxygenated [2.2.2]oxabicyclic synthons Tetrahedron Letters. 54: 6267-6270. DOI: 10.1016/j.tetlet.2013.09.030  1
2012 Mott BT, Cheng KC, Guha R, Kommer VP, Williams DL, Vermeire JJ, Cappello M, Maloney DJ, Rai G, Jadhav A, Simeonov A, Inglese J, Posner GH, Thomas CJ. A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases(). Medchemcomm. 3: 1505-1511. PMID 23205265 DOI: 10.1039/C2MD20238G  1
2012 Dixon KM, Sequeira VB, Deo SS, Mohan R, Posner GH, Mason RS. Differential photoprotective effects of 1,25-dihydroxyvitamin D3 and a low calcaemic deltanoid Photochemical and Photobiological Sciences. 11: 1825-1830. PMID 22907250 DOI: 10.1039/c2pp25208b  1
2012 Jacobine AM, Mazzone JR, Slack RD, Tripathi AK, Sullivan DJ, Posner GH. Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose. Journal of Medicinal Chemistry. 55: 7892-9. PMID 22891714 DOI: 10.1021/jm3009986  1
2012 He R, Park K, Cai H, Kapoor A, Forman M, Mott B, Posner GH, Arav-Boger R. Artemisinin-derived dimer diphenyl phosphate is an irreversible inhibitor of human cytomegalovirus replication Antimicrobial Agents and Chemotherapy. 56: 3508-3515. PMID 22547612 DOI: 10.1128/AAC.00519-12  1
2012 Slack RD, Mott BT, Woodard LE, Tripathi A, Triphati A, Sullivan D, Nenortas E, Girdwood SC, Shapiro TA, Posner GH. Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine. Journal of Medicinal Chemistry. 55: 291-6. PMID 22128829 DOI: 10.1021/jm201214d  1
2012 Slack RD, Jacobine AM, Posner GH. Antimalarial peroxides: Advances in drug discovery and design Medchemcomm. 3: 281-297. DOI: 10.1039/c2md00277a  1
2011 He R, Mott BT, Rosenthal AS, Genna DT, Posner GH, Arav-Boger R. An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activities Plos One. 6. PMID 21904628 DOI: 10.1371/journal.pone.0024334  1
2011 Genna DT, Posner GH. Cyanocuprates convert carboxylic acids directly into ketones. Organic Letters. 13: 5358-61. PMID 21894954 DOI: 10.1021/ol202237j  0.48
2011 Jacobine AM, Posner GH. Three-component, one-flask synthesis of rhodanines (thiazolidinones) Journal of Organic Chemistry. 76: 8121-8125. PMID 21853986 DOI: 10.1021/jo201561t  1
2011 Somjen D, Katzburg S, Sharon O, Posner GH, Jaccard N, Hendel D, Tamir S, Vaya J. Mutual interaction of special phytoestrogenic compounds, their synthetic carboxy-derivatives and the less-calcemic vitamin D analog activities in human derived female cultured osteoblasts Journal of Steroid Biochemistry and Molecular Biology. 127: 351-357. PMID 21810473 DOI: 10.1016/j.jsbmb.2011.07.003  1
2011 Hencken CP, Genna DT, Siegler MA, Posner GH. Highly stereocontrolled and regiocontrolled syntheses of 2,3,4-trisubstituted alkanoates and lactones. The Journal of Organic Chemistry. 76: 5149-55. PMID 21563766 DOI: 10.1021/jo200795f  1
2011 He R, Sandford G, Hayward GS, Burns WH, Posner GH, Forman M, Arav-Boger R. Recombinant luciferase-expressing human cytomegalovirus (CMV) for evaluation of CMV inhibitors. Virology Journal. 8: 40. PMID 21269468 DOI: 10.1186/1743-422X-8-40  1
2011 Somjen D, Katzburg S, Grafi-Cohen M, Knoll E, Sharon O, Posner GH. Vitamin D metabolites and analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cell line Journal of Steroid Biochemistry and Molecular Biology. 123: 85-89. PMID 21111046 DOI: 10.1016/j.jsbmb.2010.11.010  1
2011 Moon DK, Tripathi A, Sullivan D, Siegler MA, Parkin S, Posner GH. A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice. Bioorganic & Medicinal Chemistry Letters. 21: 2773-5. PMID 20952197 DOI: 10.1016/j.bmcl.2010.09.123  1
2011 Somjen D, Katzburg S, Kohen F, Gayer B, Posner GH, Yoles I, Livne E. The effects of native and synthetic estrogenic compounds as well as vitamin D less-calcemic analogs on adipocytes content in rat bone marrow Journal of Endocrinological Investigation. 34: 106-110. PMID 20543554 DOI: 10.3275/7108  1
2011 Genna DT, Posner GH. Cyanocuprates convert carboxylic acids directly into ketones Organic Letters. 13: 5358-5361. DOI: 10.1021/ol202237j  1
2010 Genna DT, Hencken CP, Siegler MA, Posner GH. α-Chloro-β,γ-ethylenic esters: enantiocontrolled synthesis and substitutions. Organic Letters. 12: 4694-7. PMID 20853879 DOI: 10.1021/ol102142a  1
2010 Xu H, Posner GH, Stevenson M, Campbell FC. ApcMIN modulation of vitamin D secosteroid growth control Carcinogenesis. 31: 1434-1441. PMID 20488884 DOI: 10.1093/carcin/bgq098  1
2010 Arav-Boger R, He R, Chiou CJ, Liu J, Woodard L, Rosenthal A, Jones-Brando L, Forman M, Posner G. Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomers Plos One. 5. PMID 20442781 DOI: 10.1371/journal.pone.0010370  1
2010 Hess LC, Posner GH. Asymmetric, organocatalytic, three-step synthesis of alpha-hydroxy-(E)-beta,gamma-unsaturated esters. Organic Letters. 12: 2120-2. PMID 20377201 DOI: 10.1021/ol100615j  1
2010 Hencken CP, Jones-Brando L, Bordón C, Stohler R, Mott BT, Yolken R, Posner GH, Woodard LE. Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondii. Journal of Medicinal Chemistry. 53: 3594-601. PMID 20373807 DOI: 10.1021/jm901857d  1
2010 Posner GH, Helvig C, Cuerrier D, Collop D, Kharebov A, Ryder K, Epps T, Petkovich M. Vitamin D analogues targeting CYP24 in chronic kidney disease Journal of Steroid Biochemistry and Molecular Biology. 121: 13-19. PMID 20347976 DOI: 10.1016/j.jsbmb.2010.03.065  1
2010 Somjen D, Katzburg S, Knoll E, Sharon O, Posner GH, Stern N. Vitamin D analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cells Journal of Steroid Biochemistry and Molecular Biology. 121: 265-267. PMID 20307663 DOI: 10.1016/j.jsbmb.2010.03.047  1
2010 Moon DK, Singhal V, Kumar N, Shapiro TA, Posner GH. Antimalarial preclinical drug development: A single oral dose of a 5-carbon-linked trioxane dimer plus mefloquine cures malaria-infected mice Drug Development Research. 71: 76-81. DOI: 10.1002/ddr.20350  1
2009 Woodard LE, Mott BT, Singhal V, Kumar N, Shapiro TA, Posner GH. Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine. Pharmaceuticals (Basel, Switzerland). 2: 228-235. PMID 27713236 DOI: 10.3390/ph2030228  0.68
2009 Moon DK, Singhal V, Kumar N, Shapiro TA, Posner GH. Antimalarial Preclinical Drug Development: A Single Oral Dose of A 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice. Drug Development Research. 71: 76-81. PMID 20686674 DOI: 10.1002/ddr.20350  0.68
2009 Woodard LE, Chang W, Chen X, Liu JO, Shapiro TA, Posner GH. Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose Journal of Medicinal Chemistry. 52: 7458-7462. PMID 19586052 DOI: 10.1021/jm9005934  1
2009 Usera AR, Dolan P, Kensler TW, Posner GH. 'Novel alkyl side chain sulfone 1α,25-dihydroxyvitamin D3 analogs: A comparison of in vitro antiproliferative activities and in vivo calcemic activities' Bioorganic and Medicinal Chemistry. 17: 5627-5631. PMID 19577932 DOI: 10.1016/j.bmc.2009.06.033  1
2009 Rosenthal AS, Chen X, Liu JO, West DC, Hergenrother PJ, Shapiro TA, Posner GH. Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells. Journal of Medicinal Chemistry. 52: 1198-203. PMID 19186946 DOI: 10.1021/jm801484v  1
2009 Xu H, McCann M, Zhang Z, Posner GH, Bingham V, El-Tanani M, Campbell FC. Vitamin D receptor modulates the neoplastic phenotype through antagonistic growth regulatory signals Molecular Carcinogenesis. 48: 759-772. PMID 19184984 DOI: 10.1002/mc.20520  1
2009 Hartwig CL, Rosenthal AS, D'Angelo J, Griffin CE, Posner GH, Cooper RA. Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent Biochemical Pharmacology. 77: 322-336. PMID 19022224 DOI: 10.1016/j.bcp.2008.10.015  1
2009 D'Angelo JG, Bordón C, Posner GH, Yolken R, Jones-Brando L. Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle. The Journal of Antimicrobial Chemotherapy. 63: 146-50. PMID 18988681 DOI: 10.1093/jac/dkn451  1
2009 Jeon HB, Posner GH. New A-ring analogs of the hormone 1α,25-dihydroxyvitamin D3: (2′-hydroxymethyl)tetrahydrofuro[1,2-a]-25-hydroxyvitamin D3 Tetrahedron. 65: 1235-1240. DOI: 10.1016/j.tet.2008.12.034  1
2008 Petersen KS, Posner GH. Asymmetric, organocatalytic, three-step synthesis of γ-hydroxy-(E)- α,β-unsaturated sulfones and esters Organic Letters. 10: 4685-4687. PMID 18811178 DOI: 10.1021/ol8020513  1
2008 Badireenath Konkimalla V, Blunder M, Korn B, Soomro SA, Jansen H, Chang W, Posner GH, Bauer R, Efferth T. Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells Nitric Oxide - Biology and Chemistry. 19: 184-191. PMID 18472018 DOI: 10.1016/j.niox.2008.04.008  1
2008 Posner GH, Maio WA, Kalinda AS. Electronically stabilized versions of the antimalarial acetal trioxanes artemether and artesunate Bioorganic and Medicinal Chemistry. 16: 5247-5253. PMID 18353653 DOI: 10.1016/j.bmc.2008.03.010  1
2008 Posner GH, Chang W, Hess L, Woodard L, Sinishtaj S, Usera AR, Maio W, Rosenthal AS, Kalinda AS, D'Angelo JG, Petersen KS, Stohler R, Chollet J, Santo-Tomas J, Snyder C, et al. Malaria-infected mice are cured by oral administration of new artemisinin derivatives. Journal of Medicinal Chemistry. 51: 1035-42. PMID 18232653 DOI: 10.1021/jm701168h  1
2008 Posner GH, Chang W. Antimalarial sulfide trioxanes: A revision of mechanism Journal of Physical Organic Chemistry. 21: 538-540. DOI: 10.1002/poc.1307  1
2007 Petersen KS, Dolan PM, Kensler TW, Peleg S, Posner GH. Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Medicinal Chemistry. 50: 5824-5832. PMID 17924616 DOI: 10.1021/jm070882d  1
2007 Zhang J, Posner GH, Danilenko M, Studzinski GP. Differentiation-inducing potency of the seco-steroid JK-1624F2-2 can be increased by combination with an antioxidant and a p38MAPK inhibitor which upregulates the JNK pathway Journal of Steroid Biochemistry and Molecular Biology. 105: 140-149. PMID 17583492 DOI: 10.1016/j.jsbmb.2007.01.003  1
2007 Maio WA, Sinishtaj S, Posner GH. Cyclopentanone ring expansion leading to functionalized delta-lactams: short synthesis of simple sedum alkaloids. Organic Letters. 9: 2673-6. PMID 17564459 DOI: 10.1021/ol070960r  1
2007 Usera AR, Dolan PM, Kensler TW, Posner GH. Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1α,25-dihydroxyvitamin D3: Chemical synthesis and biological evaluation Bioorganic and Medicinal Chemistry. 15: 5509-5518. PMID 17560112 DOI: 10.1016/j.bmc.2007.05.051  1
2007 Posner GH, Paik IH, Chang W, Borstnik K, Sinishtaj S, Rosenthal AS, Shapiro TA. Malaria-infected mice are cured by a single dose of novel artemisinin derivatives Journal of Medicinal Chemistry. 50: 2516-2519. PMID 17439113 DOI: 10.1021/jm070149m  1
2007 Somjen D, Posner GH, Weisman Y, Kaye AM. Less-calcemic vitamin D analogs enhance creatine kinase specific activity and modulate responsiveness to gonadal steroids in rat skeletal tissues Journal of Endocrinological Investigation. 30: 91-96. PMID 17392597  1
2007 Usera AR, Posner GH. Unexpected steric effects of "remote" alkyl groups on the rate of conjugate additions to alkyl α,β-ethylenic sulfones, sulfoxides, and esters Journal of Organic Chemistry. 72: 2329-2334. PMID 17341116 DOI: 10.1021/jo062155g  1
2007 Alagbala AA, Johnson CS, Trump DL, Posner GH, Foster BA. Antitumor effects of two less-calcemic vitamin D analogs (paricalcitol and QW-1624F2-2) in squamous cell carcinoma cells Oncology. 70: 483-492. PMID 17237623 DOI: 10.1159/000098813  1
2007 Posner GH, Suh BC, Petersen KS, Dolan P, Agoston ES, Kensler TW, Koh JT, Peleg S. Difluoromethyl analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Steroid Biochemistry and Molecular Biology. 103: 213-221. PMID 17218093 DOI: 10.1016/j.jsbmb.2006.12.024  1
2007 Lechner D, Manhardt T, Bajna E, Posner GH, Cross HS. A 24-phenylsulfone analog of vitamin D inhibits 1α,25- dihydroxyvitamin D3 degradation in vitamin D metabolism-competent cells Journal of Pharmacology and Experimental Therapeutics. 320: 1119-1126. PMID 17182978 DOI: 10.1124/jpet.106.115451  1
2007 Somjen D, Katzburg S, Posner GH, Livne E, Kaye AM. Systemic treatments with the low-calcemic 1,25(OH)2D3 analogs JKF or QW increase both the morphological and biochemical responses to estradiol-17β in rat tibiae Journal of Cellular Biochemistry. 100: 1406-1414. PMID 17163482 DOI: 10.1002/jcb.21143  1
2007 Maio WA, Sinishtaj S, Posner GH. Cyclopentanone ring expansion leading to functionalized δ-lactams: Short synthesis of simple sedum alkaloids Organic Letters. 9: 2673-2676. DOI: 10.1021/ol070960r  1
2007 Seydou M, Gillet JC, Li X, Wang H, Posner GH, Grégoire G, Schermann JP, Bowen KH, Desfrançois C. Studies of protonated and anionic artemisinin in the gas-phase by infrared multi-photon dissociation and by negative ion photoelectron spectroscopies Chemical Physics Letters. 449: 286-290. DOI: 10.1016/j.cplett.2007.10.086  1
2007 Hatcher MA, Posner GH. The Carroll Rearrangement The Claisen Rearrangement: Methods and Applications. 397-430. DOI: 10.1002/9783527610549.ch8  1
2006 Alagbala AA, McRiner AJ, Borstnik K, Labonte T, Chang W, D'Angelo JG, Posner GH, Foster BA. Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines Journal of Medicinal Chemistry. 49: 7836-7842. PMID 17181166 DOI: 10.1021/jm060803i  1
2006 Peleg S, Petersen KS, Suh BC, Dolan P, Agoston ES, Kensler TW, Posner GH. Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Medicinal Chemistry. 49: 7513-7517. PMID 17149880 DOI: 10.1021/jm0609925  1
2006 Sundaram S, Beckman MJ, Bajwa A, Wei J, Smith KM, Posner GH, Gewirtz DA. QW-1624F2-2, a synthetic analogue of 1,25-dihydroxyvitamin D3, enhances the response to other deltanoids and suppresses the invasiveness of human metastatic breast tumor cells Molecular Cancer Therapeutics. 5: 2806-2814. PMID 17121927 DOI: 10.1158/1535-7163.MCT-06-0092  1
2006 Jones-Brando L, D'Angelo J, Posner GH, Yolken R. In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin. Antimicrobial Agents and Chemotherapy. 50: 4206-8. PMID 17060514 DOI: 10.1128/AAC.00793-06  1
2006 Somjen D, Posner GH, Stern N. Less calcemic Vitamin D analogs enhance creatine kinase specific activity and modulate responsiveness to gonadal steroids in the vasculature Journal of Steroid Biochemistry and Molecular Biology. 101: 232-238. PMID 17029789 DOI: 10.1016/j.jsbmb.2006.06.023  1
2006 Sinishtaj S, Jeon HB, Dolan P, Kensler TW, Posner GH. Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1α,25-dihydroxyvitamin D3 Bioorganic and Medicinal Chemistry. 14: 6341-6348. PMID 16765598 DOI: 10.1016/j.bmc.2006.05.050  1
2006 Paik IH, Xie S, Shapiro TA, Labonte T, Narducci Sarjeant AA, Baege AC, Posner GH. Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity Journal of Medicinal Chemistry. 49: 2731-2734. PMID 16640333 DOI: 10.1021/jm058288w  1
2006 Agoston ES, Hatcher MA, Kensler TW, Posner GH. Vitamin D analogs as anti-carcinogenic agents Anti-Cancer Agents in Medicinal Chemistry. 6: 53-71. PMID 16475927 DOI: 10.2174/187152006784111369  1
2006 Somjen D, Katzburg S, Kohen F, Gayer B, Sharon O, Hendel D, Posner GH, Kaye AM. Responsiveness to phytoestrogens in primary human osteoblasts is modulated differentially by a "less-calcemic" analog of 1,25 dihydroxyvitamin D3: JK 1624F2-2 (JKF) Journal of Steroid Biochemistry and Molecular Biology. 98: 139-146. PMID 16406510 DOI: 10.1016/j.jsbmb.2005.08.016  1
2006 Reddy CD, Patti R, Guttapalli A, Maris JM, Yanamandra N, Rachamallu A, Sutton LN, Phillips PC, Posner GH. Anticancer effects of the novel 1alpha, 25-dihydroxyvitamin D3 hybrid analog QW1624F2-2 in human neuroblastoma. Journal of Cellular Biochemistry. 97: 198-206. PMID 16200638 DOI: 10.1002/jcb.20629  1
2006 Posner GH, D'Angelo J, O'Neill PM, Mercer A. Anticancer activity of artemisinin-derived trioxanes Expert Opinion On Therapeutic Patents. 16: 1665-1672. DOI: 10.1517/13543776.16.12.1665  1
2006 Kim J, Li HB, Rosenthal AS, Sang D, Shapiro TA, Bachi MD, Posner GH. Ground state oxygen in synthesis of cyclic peroxides. Part 1: Benzo fused ketals Tetrahedron. 62: 4120-4127. DOI: 10.1016/j.tet.2006.02.008  1
2006 Posner GH. Asymmetric Synthesis Using α-Sulfinyl Carbanions and β-Unsaturated Sulfoxides The Chemistry of Sulphones and Sulphoxides. 823-849. DOI: 10.1002/0470034386.ch16  1
2005 O'Neill PM, Rawe SL, Borstnik K, Miller A, Ward SA, Bray PG, Davies J, Oh CH, Posner GH. Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins. Chembiochem : a European Journal of Chemical Biology. 6: 2048-54. PMID 16222725 DOI: 10.1002/cbic.200500048  1
2005 Posner GH, Hatcher MA, Maio WA. New silicon-mediated, sequential ring expansions of n-sized 2-cycloalkenones into hydroxyolefinic n + m + p medium-sized lactones: short synthesis of (-)-phoracantholide-J. Organic Letters. 7: 4301-3. PMID 16146412 DOI: 10.1021/ol051854x  1
2005 Peleg S, Khan F, Navone NM, Cody DD, Johnson EM, Van Pelt CS, Posner GH. Inhibition of prostate cancer-meditated osteoblastic bone lesions by the low-calcemic analog 1alpha-hydroxymethyl-16-ene-26,27-bishomo-25-hydroxy vitamin D3. The Journal of Steroid Biochemistry and Molecular Biology. 97: 203-11. PMID 16081281 DOI: 10.1016/j.jsbmb.2005.06.015  1
2005 Posner GH, Hyung JK, Kahraman M, Heung BJ, Byung CS, Li H, Dolan P, Kensler TW. Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1α,25-dihydroxyvitamin D3 Bioorganic and Medicinal Chemistry. 13: 5569-5580. PMID 16039132 DOI: 10.1016/j.bmc.2005.06.031  1
2005 Dixon KM, Deo SS, Wong G, Slater M, Norman AW, Bishop JE, Posner GH, Ishizuka S, Halliday GM, Reeve VE, Mason RS. Skin cancer prevention: A possible role of 1,25dihydroxyvitamin D3 and its analogs Journal of Steroid Biochemistry and Molecular Biology. 97: 137-143. PMID 16039116 DOI: 10.1016/j.jsbmb.2005.06.006  1
2005 Hatcher MA, Peleg S, Dolan P, Kensler TW, Sarjeant A, Posner GH. A-ring hydroxymethyl 19-nor analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Synthesis and preliminary biological evaluation Bioorganic and Medicinal Chemistry. 13: 3964-3976. PMID 15878279 DOI: 10.1016/j.bmc.2005.04.010  1
2005 Somjen D, Kohen F, Lieberherr M, Gayer B, Schejter E, Katzburg S, Limor R, Sharon O, Knoll E, Posner GH, Kaye AM, Stern N. Membranal effects of phytoestrogens and carboxy derivatives of phytoestrogens on human vascular and bone cells: New insights based on studies with carboxy-biochanin A Journal of Steroid Biochemistry and Molecular Biology. 93: 293-303. PMID 15860273 DOI: 10.1016/j.jsbmb.2004.12.029  1
2005 Posner GH, Lee SHT, Kim HJ, Peleg S, Dolan P, Kensler TW. Novel A-ring analogs of the hormone 1α,25-dihydroxyvitamin D 3: Synthesis and preliminary biological evaluation Bioorganic and Medicinal Chemistry. 13: 2959-2966. PMID 15781405 DOI: 10.1016/j.bmc.2005.02.005  1
2005 Posner GH, Hatcher MA, Maio WA. New silicon-mediated, sequential ring expansions of n-sized 2-cycloalkenones into hydroxyolefinic n + m + p medium-sized lactones: Short synthesis of (-)-phoracantholide-J Organic Letters. 7: 4301-4303. DOI: 10.1021/ol051854x  1
2005 O'Neill PM, Rawe SL, Storr RC, Ward SA, Posner GH. Lewis acid catalysed rearrangements of unsaturated bicyclic [2.2.n] endoperoxides in the presence of vinyl silanes; access to novel Fenozan BO-7 analogues Tetrahedron Letters. 46: 3029-3032. DOI: 10.1016/j.tetlet.2005.03.022  1
2005 Posner GH, Kahraman M. Overview: Rational Design of 1α,25-Dihydroxyvitamin D3 Analogs (Deltanoids) Vitamin D. 2: 1405-1422. DOI: 10.1016/B978-012252687-9/50084-X  1
2004 Kahraman M, Sinishtaj S, Dolan PM, Kensler TW, Peleg S, Saha U, Chuang SS, Bernstein G, Korczak B, Posner GH. Potent, selective and low-calcemic inhibitors of CYP24 Hydroxylase: 24-Sulfoximine analogues of the hormone 1α,25-dihydroxyvitamin D 3 Journal of Medicinal Chemistry. 47: 6854-6863. PMID 15615534 DOI: 10.1021/jm040129+  1
2004 Posner GH, Jeon HB, Sarjeant A, Riccio ES, Doppalapudi RS, Kapetanovic IM, Saha U, Dolan P, Kensler TW. Low-calcemic, efficacious, 1α,25-dihydroxyvitamin D 3 analog QW-1624F 2-2: Calcemic dose-response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry Steroids. 69: 757-762. PMID 15579327 DOI: 10.1016/j.steroids.2004.09.004  1
2004 Somjen D, Katzburg S, Vaya J, Kaye AM, Hendel D, Posner GH, Tamir S. Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues Journal of Steroid Biochemistry and Molecular Biology. 91: 241-246. PMID 15336701 DOI: 10.1016/j.jsbmb.2004.04.008  1
2004 Wong G, Gupta R, Dixon KM, Deo SS, Choong SM, Halliday GM, Bishop JE, Ishizuka S, Norman AW, Posner GH, Mason RS. 1,25-Dihydroxyvitamin D and three low-calcemic analogs decrease UV-induced DNA damage via the rapid response pathway Journal of Steroid Biochemistry and Molecular Biology. 89: 567-570. PMID 15225840 DOI: 10.1016/j.jsbmb.2004.03.072  1
2004 Somjen D, Kohen F, Gayer B, Knoll E, Limor R, Baz M, Sharon O, Posner GH, Stern N. A non-calcemic Vitamin D analog modulates both nuclear and putative membranal estrogen receptors in cultured human vascular smooth muscle cells Journal of Steroid Biochemistry and Molecular Biology. 89: 397-399. PMID 15225808 DOI: 10.1016/j.jsbmb.2004.03.006  1
2004 Somjen D, Katzburg S, Sharon O, Kaye AM, Gayer B, Kohen F, Hendel D, Posner GH. Modulation of response to estrogens in cultured human female bone cells by a non-calcemic Vitamin D analog: Changes in nuclear and membranal binding Journal of Steroid Biochemistry and Molecular Biology. 89: 393-395. PMID 15225807 DOI: 10.1016/j.jsbmb.2004.03.005  1
2004 Somjen D, Katzburg S, Baz M, Stern N, Posner GH. Modulation of the response to estradiol-17β of rat vascular tissues by a non calcemic vitamin D analog Journal of Steroid Biochemistry and Molecular Biology. 89: 339-341. PMID 15225797 DOI: 10.1016/j.jsbmb.2004.03.022  1
2004 Posner GH, Crawford KR, Yang HW, Kahraman M, Jeon HB, Li H, Lee JK, Suh BC, Hatcher MA, Labonte T, Usera A, Dolan PM, Kensler TW, Peleg S, Jones G, et al. Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-Sulfone analogs of the hormone 1α,25-dihydroxyvitamin D3 Journal of Steroid Biochemistry and Molecular Biology. 89: 5-12. PMID 15225738 DOI: 10.1016/j.jsbmb.2004.03.044  1
2004 Posner GH, O'Neill PM. Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides Accounts of Chemical Research. 37: 397-404. PMID 15196049 DOI: 10.1021/ar020227u  1
2004 O'Neill PM, Posner GH. A medicinal chemistry perspective on artemisinin and related endoperoxides Journal of Medicinal Chemistry. 47: 2945-2964. PMID 15163175 DOI: 10.1021/jm030571c  1
2004 Katzburg S, Hendel D, Waisman A, Posner GH, Kaye AM, Somjen D. Treatment with non-hypercalcemic analogs of 1,25-dihydroxyvitamin D3 increases responsiveness to 17beta-estradiol, dihydrotestosterone or raloxifene in primary human osteoblasts. The Journal of Steroid Biochemistry and Molecular Biology. 88: 213-9. PMID 15084353 DOI: 10.1016/j.jsbmb.2003.11.010  1
2004 Posner GH, McRiner AJ, Paik IH, Sur S, Borstnik K, Xie S, Shapiro TA, Alagbala A, Foster B. Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents. Journal of Medicinal Chemistry. 47: 1299-301. PMID 14971910 DOI: 10.1021/jm0303711  1
2004 Jeyadevan JP, Bray PG, Chadwick J, Mercer AE, Byrne A, Ward SA, Park BK, Williams DP, Cosstick R, Davies J, Higson AP, Irving E, Posner GH, O'Neill PM. Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin. Journal of Medicinal Chemistry. 47: 1290-8. PMID 14971909 DOI: 10.1021/jm030974c  1
2004 Suh BC, Jeon H, Posner GH, Silverman SM. Vitamin D side chain triazole analogs via cycloaddition 'click' chemistry Tetrahedron Letters. 45: 4623-4625. DOI: 10.1016/j.tetlet.2004.04.118  1
2003 Peleg S, Posner GH. Vitamin D analogs as modulators of vitamin D receptor action. Current Topics in Medicinal Chemistry. 3: 1555-1572. PMID 14683515  1
2003 Guyton KZ, Kensler TW, Posner GH. Vitamin D and vitamin D analogs as cancer chemopreventive agents. Nutrition Reviews. 61: 227-38. PMID 12918875 DOI: 10.1301/nr.2003.jul.227-238  1
2003 Bachi MD, Korshin EE, Hoos R, Szpilman AM, Ploypradith P, Xie S, Shapiro TA, Posner GH. A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides. Journal of Medicinal Chemistry. 46: 2516-33. PMID 12773055 DOI: 10.1021/jm020584a  1
2003 Posner GH, Maxwell JP, Kahraman M. Mild, fast, and stereoselective epoxide opening by ketone enolate anions. Application to synthesis of the norlignan curculigine. The Journal of Organic Chemistry. 68: 3049-54. PMID 12688771 DOI: 10.1021/jo020744q  1
2003 Posner GH, Paik IH, Sur S, McRiner AJ, Borstnik K, Xie S, Shapiro TA. Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy. Journal of Medicinal Chemistry. 46: 1060-5. PMID 12620083 DOI: 10.1021/jm020461q  1
2003 Hatcher MA, Borstnik K, Posner GH. New silicon-mediated ring expansion of n-sized conjugated cycloalkenones into homoallylic n+3 lactones Tetrahedron Letters. 44: 5407-5409. DOI: 10.1016/S0040-4039(03)01308-X  1
2003 Posner GH, Kahraman M. Organic Chemistry of Vitamin D Analogues (Deltanoids) European Journal of Organic Chemistry. 3889-3895.  1
2002 Posner GH. Low-calcemic vitamin D analogs (deltanoids) for human cancer prevention. The Journal of Nutrition. 132: 3802S-3803S. PMID 12468627  1
2002 Borstnik K, Paik IH, Shapiro TA, Posner GH. Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds. International Journal For Parasitology. 32: 1661-7. PMID 12435451 DOI: 10.1016/S0020-7519(02)00195-9  1
2002 Borstnik K, Paik IH, Posner GH. Malaria: new chemotherapeutic peroxide drugs. Mini Reviews in Medicinal Chemistry. 2: 573-83. PMID 12370042  1
2002 Carreño MC, Ribagorda M, Posner GH. Titanium-promoted stereoselective synthesis of hydroindolones from p-quinamines by domino conjugate additions. Angewandte Chemie (International Ed. in English). 41: 2753-5. PMID 12203474 DOI: 10.1002/1521-3773(20020802)41:15<2753::AID-ANIE2753>3.0.CO;2-M  1
2002 Posner GH, Jeon HB, Ploypradith P, Paik IH, Borstnik K, Xie S, Shapiro TA. Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents. Journal of Medicinal Chemistry. 45: 3824-8. PMID 12190305 DOI: 10.1021/jm020210h  1
2002 Posner GH, Woodard BT, Crawford KR, Peleg S, Brown AJ, Dolan P, Kensler TW. 2,2-Disubstituted analogues of the natural hormone 1 alpha,25-dihydroxyvitamin D(3): chemistry and biology. Bioorganic & Medicinal Chemistry. 10: 2353-65. PMID 11983533 DOI: 10.1016/S0968-0896(02)00058-5  1
2002 Posner GH, Halford BA, Peleg S, Dolan P, Kensler TW. Conceptually new low-calcemic oxime analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): synthesis and biological testing. Journal of Medicinal Chemistry. 45: 1723-30. PMID 11931627 DOI: 10.1021/jm010560o  1
2002 Posner GH, Northrop J, Paik IH, Borstnik K, Dolan P, Kensler TW, Xie S, Shapiro TA. New chemical and biological aspects of artemisinin-derived trioxane dimers. Bioorganic & Medicinal Chemistry. 10: 227-32. PMID 11738625 DOI: 10.1016/S0968-0896(01)00270-X  1
2002 Hatcher MA, Posner GH. [3,3]-Sigmatropic rearrangements: Short, stereocontrolled syntheses of functionalized vitamin D3 side-chain units Tetrahedron Letters. 43: 5009-5012. DOI: 10.1016/S0040-4039(02)00904-8  1
2002 Korshin EE, Hoos R, Szpilman AM, Konstantinovski L, Posner GH, Bachi MD. An efficient synthesis of bridged-bicyclic peroxides structurally related to antimalarial yingzhaosu A based on radical co-oxygenation of thiols and monoterpenes Tetrahedron. 58: 2449-2469. DOI: 10.1016/S0040-4020(02)00126-6  1
2001 Szpilman AM, Korshin EE, Hoos R, Posner GH, Bachi MD. Iron(II)-induced degradation of antimalarial beta-sulfonyl endoperoxides: evidence for the generation of potentially cytotoxic carbocations. The Journal of Organic Chemistry. 66: 6531-40. PMID 11578201 DOI: 10.1021/jo001265z  1
2001 Posner GH, Crawford KR, Peleg S, Welsh JE, Romu S, Gewirtz DA, Gupta MS, Dolan P, Kensler TW. A non-calcemic sulfone version of the vitamin D(3) analogue seocalcitol (EB 1089): chemical synthesis, biological evaluation and potency enhancement of the anticancer drug adriamycin. Bioorganic & Medicinal Chemistry. 9: 2365-71. PMID 11553477 DOI: 10.1016/S0968-0896(01)00159-6  1
2001 Posner GH, Jeon HB, Parker MH, Krasavin M, Paik IH, Shapiro TA. Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents. Journal of Medicinal Chemistry. 44: 3054-8. PMID 11543673 DOI: 10.1021/jm0102396  1
2001 Somjen D, Waisman A, Lee JK, Posner GH, Kaye AM. A non-calcemic analog of 1 alpha,25 dihydroxy vitamin D(3) (JKF) upregulates the induction of creatine kinase B by 17 beta estradiol in osteoblast-like ROS 17/2.8 cells and in rat diaphysis. The Journal of Steroid Biochemistry and Molecular Biology. 77: 205-12. PMID 11457658 DOI: 10.1016/S0960-0760(01)00065-6  1
2001 White MC, Burke MD, Peleg S, Brem H, Posner GH. Conformationally restricted hybrid analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): design, synthesis, and biological evaluation. Bioorganic & Medicinal Chemistry. 9: 1691-9. PMID 11425569 DOI: 10.1016/S0968-0896(01)00087-6  1
2001 Posner GH, Meshnick SR, Olliaro PL, Haynes RK, Meunier B, Yuthavong Y. Radical mechanism of action of the artemisinin-type compounds (multiple letters [2]) Trends in Parasitology. 17: 266-268. PMID 11378030 DOI: 10.1016/S1471-4922(01)02001-3  1
2001 Gardezi SA, Nguyen C, Malloy PJ, Posner GH, Feldman D, Peleg S. A rationale for treatment of hereditary vitamin D-resistant rickets with analogs of 1 alpha,25-dihydroxyvitamin D(3). The Journal of Biological Chemistry. 276: 29148-56. PMID 11369766 DOI: 10.1074/jbc.M100898200  1
2001 Guyton KZ, Kensler TW, Posner GH. Cancer chemoprevention using natural vitamin D and synthetic analogs. Annual Review of Pharmacology and Toxicology. 41: 421-42. PMID 11264464 DOI: 10.1146/annurev.pharmtox.41.1.421  1
2001 Weiskopf AS, Vouros P, Cunniff J, Binderup E, Björkling F, Binderup L, White MC, Posner GH. Examination of structurally selective derivatization of vitamin D(3) analogues by electrospray mass spectrometry. Journal of Mass Spectrometry : Jms. 36: 71-8. PMID 11180648 DOI: 10.1002/jms.105  1
2001 Kadiyala S, Nagaba S, Takeuchi K, Yukihiro S, Qiu W, Eyes ST, Uskokovic MR, Posner GH, Reddy GS, Guggino SE. Metabolites and analogs of 1alpha,25-dihydroxyvitamin D(3): evaluation of actions in bone. Steroids. 66: 347-55. PMID 11179743 DOI: 10.1016/S0039-128X(00)00167-7  1
2001 O'Neill PM, Miller A, Bishop LP, Hindley S, Maggs JL, Ward SA, Roberts SM, Scheinmann F, Stachulski AV, Posner GH, Park BK. Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin. Journal of Medicinal Chemistry. 44: 58-68. PMID 11141088 DOI: 10.1021/jm000987f  1
2000 Posner GH, Crawford K, Siu-Caldera ML, Reddy GS, Sarabia SF, Feldman D, van Etten E, Mathieu C, Gennaro L, Vouros P, Peleg S, Dolan PM, Kensler TW. Conceptually new 20-epi-22-oxa sulfone analogues of the hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and biological evaluation. Journal of Medicinal Chemistry. 43: 3581-6. PMID 11000014 DOI: 10.1021/jm000215j  1
2000 Posner GH, Maxwell JP, O'Dowd H, Krasavin M, Xie S, Shapiro TA. Antimalarial sulfide, sulfone, and sulfonamide trioxanes. Bioorganic & Medicinal Chemistry. 8: 1361-70. PMID 10896113 DOI: 10.1016/S0968-0896(00)00079-1  1
2000 Kensler TW, Dolan PM, Gange SJ, Lee JK, Wang Q, Posner GH. Conceptually new deltanoids (vitamin D analogs) inhibit multistage skin tumorigenesis. Carcinogenesis. 21: 1341-5. PMID 10874012  1
2000 Posner GH, Wang Q, Halford BA, Elias JS, Maxwell JP. New synthetic methodology for ring expansion of n-sized conjugated cycloalkenones into homoallylic n+3 lactones: Three-step synthesis of fragrant phoracantholide Tetrahedron Letters. 41: 9655-9659.  1
1999 Posner GH, Ploypradith P, Parker MH, O'Dowd H, Woo SH, Northrop J, Krasavin M, Dolan P, Kensler TW, Xie S, Shapiro TA. Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers. Journal of Medicinal Chemistry. 42: 4275-80. PMID 10543871 DOI: 10.1021/jm990363d  1
1999 Hofer H, Ho Gm, Peterlik M, Uskokovic MR, Lee JK, White MC, Posner GH, Cross HS. Biological effects of 1alpha-hydroxy- and 1beta-(hydroxymethyl)-vitamin D compounds relevant for potential colorectal cancer therapy. The Journal of Pharmacology and Experimental Therapeutics. 291: 450-5. PMID 10525058  1
1999 Posner GH, Wang Q, Han G, Lee JK, Crawford K, Zand S, Brem H, Peleg S, Dolan P, Kensler TW. Conceptually new sulfone analogues of the hormone 1alpha, 25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation. Journal of Medicinal Chemistry. 42: 3425-35. PMID 10479276 DOI: 10.1021/jm990267c  1
1999 Pedrozo HA, Schwartz Z, Rimes S, Sylvia VL, Nemere I, Posner GH, Dean DD, Boyan BD. Physiological importance of the 1,25(OH)2D3 membrane receptor and evidence for a membrane receptor specific for 24,25(OH)2D3. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 14: 856-67. PMID 10352093 DOI: 10.1359/jbmr.1999.14.6.856  1
1999 Boyan BD, Sylvia VL, Dean DD, Pedrozo H, Del Toro F, Nemere I, Posner GH, Schwartz Z. 1,25-(OH)2D3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2. Steroids. 64: 129-36. PMID 10323681 DOI: 10.1016/S0039-128X(98)00099-3  1
1999 Posner GH, Parker MH, Northrop J, Elias JS, Ploypradith P, Xie S, Shapiro TA. Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family. Journal of Medicinal Chemistry. 42: 300-4. PMID 9925735 DOI: 10.1021/jm980529v  1
1999 O'Dowd H, Ploypradith P, Suji X, Shapiro TA, Posner GH. Antimalarial artemisinin analogs. Synthesis via chemoselective C-C bond formation and preliminary biological evaluation Tetrahedron. 55: 3625-3636. DOI: 10.1016/S0040-4020(98)01170-3  1
1999 O' Neill PM, Miller A, Bickley JF, Scheinmann F, Oh CH, Posner GH. Asymmetric syntheses of enantiomeric 3-p-fluorophenyl 1,2,4-trioxane analogues of the antimalarial artemisinin Tetrahedron Letters. 40: 9133-9136.  1
1999 Wu WM, Wu YK, Wu YL, Yao ZL, Yao ZJ, Zhou CM, Li Y, Shan F, Posner GH, O'Dowd H, Playpradith P, Ploypradith P, Cumming JN, Xie S, Shapiro TA, et al. Recent major advances in the studies on Qinghaosu and related antimalarial agents Chemtracts. 12: 687-694.  1
1999 Korshin EE, Posner GH, Li WS. A new approach to steroid ring construction based on a novel radical cascade sequence Chemtracts. 12: 45-51.  1
1998 Bachi MD, Korshin EE, Ploypradith P, Cumming JN, Xie S, Shapiro TA, Posner GH. Synthesis and in vitro antimalarial activity of sulfone endoperoxides. Bioorganic & Medicinal Chemistry Letters. 8: 903-8. PMID 9871509 DOI: 10.1016/S0960-894X(98)00141-3  1
1998 Posner GH, Lee JK, Wang Q, Peleg S, Burke M, Brem H, Dolan P, Kensler TW. Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1alpha, 25-dihydroxyvitamin D3. Synthesis and preliminary biological evaluation. Journal of Medicinal Chemistry. 41: 3008-14. PMID 9685240 DOI: 10.1021/jm980031t  1
1998 Posner GH, O'Dowd H, Ploypradith P, Cumming JN, Xie S, Shapiro TA. Antimalarial cyclic peroxy ketals. Journal of Medicinal Chemistry. 41: 2164-7. PMID 9622557 DOI: 10.1021/jm980088f  1
1998 van Lieshout EM, Posner GH, Woodard BT, Peters WH. Effects of the sulforaphane analog compound 30, indole-3-carbinol, D-limonene or relafen on glutathione S-transferases and glutathione peroxidase of the rat digestive tract. Biochimica Et Biophysica Acta. 1379: 325-36. PMID 9545594 DOI: 10.1016/S0304-4165(97)00112-8  1
1998 Peleg S, Nguyen C, Woodard BT, Lee JK, Posner GH. Differential use of transcription activation function 2 domain of the vitamin D receptor by 1,25-dihydroxyvitamin D3 and its A ring-modified analogs. Molecular Endocrinology (Baltimore, Md.). 12: 525-35. PMID 9544988 DOI: 10.1210/mend.12.4.0083  1
1998 Cumming JN, Wang D, Park SB, Shapiro TA, Posner GH. Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin. Journal of Medicinal Chemistry. 41: 952-64. PMID 9526569 DOI: 10.1021/jm970711g  0.68
1998 Posner GH, Cumming JN, Woo SH, Ploypradith P, Xie S, Shapiro TA. Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation. Journal of Medicinal Chemistry. 41: 940-51. PMID 9526568 DOI: 10.1021/jm970686e  1
1998 Posner GH. Antimalarial peroxides in the qinghaosu (artemisinin) and yingzbaosu families Expert Opinion On Therapeutic Patents. 8: 1487-1493. DOI: 10.1517/13543776.8.11.1487  1
1998 O'Neill PM, Searle NL, Raynes KJ, Maggs JL, Ward SA, Storr RC, Park BK, Posner GH. A carbonyl oxide route to antimalarial Yingzhaosu A analogues: Synthesis and antimalarial activity Tetrahedron Letters. 39: 6065-6068. DOI: 10.1016/S0040-4039(98)01248-9  1
1998 Posner GH, O'Dowd H, Caferro T, Cumming JN, Ploypradith P, Xie S, Shapiro TA. Antimalarial sulfone trioxanes Tetrahedron Letters. 39: 2273-2276. DOI: 10.1016/S0040-4039(98)00290-1  1
1998 Woo SH, Parker MH, Ploypradith P, Northrop J, Posner GH. Direct conversion of pyranose anomeric OH→F→R in the artemisinin family of antimalarial trioxanes Tetrahedron Letters. 39: 1533-1536. DOI: 10.1016/S0040-4039(98)00132-4  1
1998 Bunnage ME, Nicolaou KC, Wang Q, Posner GH. Enediyne generation by a retro-diels-alder reaction Chemtracts. 11: 1025-1029.  1
1998 Posner GH, O'Dowd H. An antimalarially active cyclic peroxy ketal Heterocycles. 47: 643-646.  1
1998 Cho CG, Posner GH. Asymmetric Intramolecular Diels-Alder Cycloadditions of 2-Pyrone-3-Carboxylates and Synthesis of Vitamin D3 a Ring Phosphine Oxide Bulletin of the Korean Chemical Society. 19: 957-961.  1
1998 Crawford KR, Posner GH. A highly stereoselective pentannulation of prochiral cyclic enones using a chiral 1,3-dipole equivalent Chemtracts. 11: 561-564.  1
1997 Posner GH, Lee JK, White MC, Hutchings RH, Dai H, Kachinski JL, Dolan P, Kensler TW. Antiproliferative Hybrid Analogs of the Hormone 1alpha,25-Dihydroxyvitamin D(3): Design, Synthesis, and Preliminary Biological Evaluation. The Journal of Organic Chemistry. 62: 3299-3314. PMID 11671717  0.68
1997 Posner GH, Ploypradith P, Hapangama W, Wang D, Cumming JN, Dolan P, Kensler TW, Klinedinst D, Shapiro TA, Zheng QY, Murray CK, Pilkington LG, Jayasinghe LR, Bray JF, Daughenbaugh R. Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro. Bioorganic & Medicinal Chemistry. 5: 1257-65. PMID 9377085 DOI: 10.1016/S0968-0896(97)00079-5  1
1997 Boyan BD, Posner GH, Greising DM, White MC, Sylvia VL, Dean DD, Schwartz Z. Hybrid structural analogues of 1,25-(OH)2D3 regulate chondrocyte proliferation and proteoglycan production as well as protein kinase C through a nongenomic pathway. Journal of Cellular Biochemistry. 66: 457-70. PMID 9282324 DOI: 10.1002/(SICI)1097-4644(19970915)66:4<457::AID-JCB5>3.0.CO;2-K  1
1997 Greising DM, Schwartz Z, Posner GH, Sylvia VL, Dean DD, Boyan BD. A-ring analogues of 1, 25-(OH)2D3 with low affinity for the vitamin D receptor modulate chondrocytes via membrane effects that are dependent on cell maturation. Journal of Cellular Physiology. 171: 357-67. PMID 9180905 DOI: 10.1002/(SICI)1097-4652(199706)171:3<357::AID-JCP14>3.0.CO;2-7  1
1997 Cumming JN, Ploypradith P, Posner GH. Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action. Advances in Pharmacology (San Diego, Calif.). 37: 253-97. PMID 8891104  1
1997 Posner GH, Lee JK, White MC, Hutchings RH, Dai H, Kachinski JL, Dolan P, Kensler TW. Antiproliferative Hybrid Analogs of the Hormone 1α,25-Dihydroxyvitamin D3: Design, Synthesis, and Preliminary Biological Evaluation Journal of Organic Chemistry. 62: 3291-3298. DOI: 10.1021/jo970049w  1
1997 Posner GH, González L, Cumming JN, Klinedinst D, Shapiro TA. Synthesis and antimalarial activity of heteroatom-containing bicyclic endoperoxides Tetrahedron. 53: 37-50. DOI: 10.1016/S0040-4020(96)00975-1  1
1997 Oh CH, Wang D, Cumming JN, Posner GH. Antimalarial 1,2,4-trioxanes related to artemisinin: rules for assignment of relative stereochemistry in diversely substituted analogs Spectroscopy Letters. 30: 241-255.  1
1997 Oh CH, Posner GH. Syntheses and Iron(II) Induced Reactions of Phenyl-Substituted 1,2,4-Trioxanes Bulletin of the Korean Chemical Society. 18: 644-648.  1
1997 Posner GH, Hutchings RH, Woodard BT. Regiocontrolled and stereocontrolled Diels-Alder cycloadditions of 2-pyrones and unactivated, unbranched 1-alkenes Synlett. 432-434.  1
1997 Posner GH. Antimalarial endoperoxides that are potent and easily synthesized Journal of Pharmacy and Pharmacology. 49: 55-57.  1
1996 Meshnick SR, Jefford CW, Posner GH, Avery MA, Peters W. Second-generation antimalarial endoperoxides. Parasitology Today (Personal Ed.). 12: 79-82. PMID 15275260 DOI: 10.1016/0169-4758(96)80660-0  1
1996 Posner GH, Dai H, Bull DS, Lee JK, Eydoux F, Ishihara Y, Welsh W, Pryor N, Petr S. Lewis Acid-Promoted, Stereocontrolled, Gram Scale, Diels-Alder Cycloadditions of Electronically Matched 2-Pyrones and Vinyl Ethers: The Critical Importance of Molecular Sieves and the Temperature of Titanium Coordination with the Pyrone. The Journal of Organic Chemistry. 61: 671-676. PMID 11666990  0.68
1996 Peleg S, Liu YY, Reddy S, Horst RL, White MC, Posner GH. A 20-epi side chain restores growth-regulatory and transcriptional activities of an A ring-modified hybrid analog of 1 alpha, 25-dihydroxyvitamin D3 without increasing its affinity to the vitamin D receptor. Journal of Cellular Biochemistry. 63: 149-61. PMID 8913867 DOI: 10.1002/(SICI)1097-4644(19961101)63:2<149::AID-JCB3>3.0.CO;2-Y  1
1996 Posner GH. New vitamin D analogues. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 11: 32-6. PMID 8840309  1
1996 Cumming JN, Ploypradith P, Posner GH. Antimalarial Activity of Artemisinin (Qinghaosu) and Related Trioxanes: Mechanism (s) of Action Advances in Pharmacology. 37: 253-297. DOI: 10.1016/S1054-3589(08)60952-7  1
1996 Posner GH, Tao X, Cumming JN, Klinedinst D, Shapiro TA. Antimalarially potent, easily prepared, fluorinated endoperoxides Tetrahedron Letters. 37: 7225-7228. DOI: 10.1016/0040-4039(96)01625-5  1
1996 Posner GH, Bull DS. Molecular sieves promote stereocontrolled αα-disaccharide formation via direct dimerization of free sugars Tetrahedron Letters. 37: 6279-6282. DOI: 10.1016/0040-4039(96)01376-7  1
1996 Posner GH, Wang D, González L, Tao X, Cumming JN, Klinedinst D, Shapiro TA. Mechanism-based design of simple, symmetrical, easily prepared, potent antimalarial endoperoxides Tetrahedron Letters. 37: 815-818. DOI: 10.1016/0040-4039(95)02329-1  1
1996 Posner GH, Afarinkia K, Dai H. An improved preparation of 3-bromo-2(H)-Pyran-2-one: An ambiphilic diene for diels-alder cycloadditions: (2H-Pyran-2-one, 3-bromo-) Organic Syntheses. 73: 231-238.  1
1996 Posner GH, Park SB, González L, Wang D, Cumming JN, Klinedinst D, Shapiro TA, Bachi MD. Evidence for the importance of high-valent Fe=O and of a diketone in the molecular mechanism of action of antimalarial trioxane analogs of artemisinin Journal of the American Chemical Society. 118: 3537-3538.  1
1996 Posner GH, Dai H, Bull DS, Lee JK, Eydoux F, Ishihara Y, Welsh W, Pryor N, Petr S. Lewis acid-promoted, stereocontroiled, gram scale, diels-alder cycloadditions of electronically matched 2-pyrones and vinyl ethers: The critical importance of molecular sieves and the temperature of titanium coordination with the pyrone Journal of Organic Chemistry. 61: 671-676.  1
1995 Posner GH, McGarvey DJ, Oh CH, Kumar N, Meshnick SR, Asawamahasadka W. Structure-activity relationships of lactone ring-opened analogs of the antimalarial 1,2,4-trioxane artemisinin. Journal of Medicinal Chemistry. 38: 607-12. PMID 7861408  1
1995 Posner GH, Wang D, Cumming JN, Oh CH, French AN, Bodley AL, Shapiro TA. Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin. Journal of Medicinal Chemistry. 38: 2273-5. PMID 7608890  1
1995 Posner GH, Li Z, White MC, Vinader V, Takeuchi K, Guggino SE, Dolan P, Kensler TW. 1 alpha,25-dihydroxyvitamin D3 analogs featuring aromatic and heteroaromatic rings: design, synthesis, and preliminary biological testing. Journal of Medicinal Chemistry. 38: 4529-37. PMID 7473581  1
1995 Posner GH, Lee JK, Li Z, Takeuchi K, Guggino SE, Dolan P, Kensler TW. 1α,25-Dihydroxyvitamin D3 Hybrid Analogs with Structural changes at both the A-ring and the C,D-ring side-chain. II Bioorganic and Medicinal Chemistry Letters. 5: 2163-2168. DOI: 10.1016/0960-894X(95)00376-5  1
1995 Posner GH, Cho CG, Anje TEN, Johnson N, Horst RL, Kobayashi T, Okano T, Tsugawa N. 2-Fluoroalkyl a-ring analogs of 1,25-dihydroxyvitamin D3. Stereocontrolled total synthesis via intramolecular and intermolecular Diels-Alder cycloadditions. Preliminary biological testing Journal of Organic Chemistry. 60: 4617-4628.  1
1995 Posner GH, Cumming JN, Ploypradith P, Oh CH. Evidence for Fe(IV)=O in the molecular mechanism of action of the trioxane antimalarial artemisinin Journal of the American Chemical Society. 117: 5885-5886.  1
1994 Posner GH, Cho CG, Green JV, Zhang Y, Talalay P. Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes. Journal of Medicinal Chemistry. 37: 170-6. PMID 8289191  1
1994 Posner GH, Oh CH, Wang D, Gerena L, Milhous WK, Meshnick SR, Asawamahasadka W. Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity. Journal of Medicinal Chemistry. 37: 1256-8. PMID 8176702  1
1994 Posner GH, Oh CH, Webster HK, Ager AL, Rossan RN. New, antimalarial, tricyclic 1,2,4-trioxanes: evaluations in mice and monkeys. The American Journal of Tropical Medicine and Hygiene. 50: 522-6. PMID 8166360  1
1994 Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proceedings of the National Academy of Sciences of the United States of America. 91: 3147-50. PMID 8159717  1
1994 Yukihiro S, Posner GH, Guggino SE. Vitamin D3 analogs stimulate calcium currents in rat osteosarcoma cells. The Journal of Biological Chemistry. 269: 23889-93. PMID 7929036  1
1994 Posner GH, Ishihara Y. Lewis acid-catalyzed, high pressure, stereospecific, regiospecific, Diels-Alder cycloaddition of unsubstituted 2-pyrone: Short synthesis of a racemic A-ring precursor to physiologically active 1-hydroxyvitamin D3 steroids Tetrahedron Letters. 35: 7545-7548. DOI: 10.1016/S0040-4039(00)78339-0  1
1994 Posner GH, Eydoux F, Lee JK, Bull DS. Binaphthol-titanium-promoted, highly enantiocontrolled, Diels-Alder cycloadditions of electronically matched 2-pyrones and vinyl ethers: Streamlined asymmetric synthesis of an A-ring precursor to physiologically active 1α-hydroxyvitamin D3 steroids Tetrahedron Letters. 35: 7541-7544. DOI: 10.1016/S0040-4039(00)78338-9  1
1994 Posner GH, Carry JC, Kyoo Lee J, Bull DS, Dai H. Mild, asymmetric Diels-Alder cycloadditions of electronically matched 2-pyrones and vinyl ethers Tetrahedron Letters. 35: 1321-1324. DOI: 10.1016/S0040-4039(00)76207-1  1
1994 Dai H, Posner GH. Synthetic approaches to vitamin D Synthesis. 1383-1398.  1
1994 Posner GH, Johnson N. Stereocontrolled total synthesis of calcitriol derivatives: 1,25-Dihydroxy-2-(4′-hydroxybutyl)vitamin D3 analogs of an osteoporosis drug Journal of Organic Chemistry. 59: 7855-7861.  1
1993 Posner GH, Guyton KZ, Kensler TW, Barsony J, Lieberman ME, Reddy GS, Clark JW, Wankadiya KF, Tserng KT. 1-(hydroxyalkyl)-25-hydroxyvitamin D3 analogs of calcitriol. 2. Preliminary biological evaluation Bioorganic and Medicinal Chemistry Letters. 3: 1835-1840. DOI: 10.1016/S0960-894X(00)80115-8  1
1993 Posner GH, Dai H. 1-(hydroxyalkyl)-25-hydroxyvitamin D3 analogs of calcitriol. 1. Synthesis Bioorganic and Medicinal Chemistry Letters. 3: 1829-1834. DOI: 10.1016/S0960-894X(00)80114-6  1
1993 Posner GH, Dai H, Afarinkia K, Murthy NN, Guyton KZ, Kensler TW. Asymmetric total synthesis, X-ray crystallography, and preliminary biological evaluation of 1-(1′-hydroxyethyl)-25-hydroxyvitamin D3 analogs of natural calcitriol Journal of Organic Chemistry. 58: 7209-7215.  1
1993 Roux MC, Seyden-Penne J, Wartski L, Posner GH, Nierlich M, Vigner D, Lance M. Scope of [1 + 2 + 3] annulations using aminonitriles as Michael donors Journal of Organic Chemistry. 58: 3969-3973.  1
1992 Posner GH, Oh CH, Gerena L, Milhous WK. Extraordinarily potent antimalarial compounds: new, structurally simple, easily synthesized, tricyclic 1,2,4-trioxanes. Journal of Medicinal Chemistry. 35: 2459-67. PMID 1619620  0.44
1992 Zhang Y, Talalay P, Cho CG, Posner GH. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proceedings of the National Academy of Sciences of the United States of America. 89: 2399-403. PMID 1549603  1
1992 Zhang Y, Cho CG, Posner GH, Talalay P. Spectroscopic quantitation of organic isothiocyanates by cyclocondensation with vicinal dithiols. Analytical Biochemistry. 205: 100-7. PMID 1443546 DOI: 10.1016/0003-2697(92)90585-U  1
1992 Posner GH, Nelson TD, Guyton KZ, Kensler TW. New vitamin D3 derivatives with unexpected antiproliferative activity: 1-(hydroxymethyl)-25-hydroxyvitamin D3 homologs. Journal of Medicinal Chemistry. 35: 3280-7. PMID 1324319  1
1992 Afarinkia K, Posner GH. 5-Bromo-2-pyrone: An easily prepared ambiphilic diene and a synthetic equivalent of 2-pyrone in mild, thermal, Diels-Alder cycloadditions Tetrahedron Letters. 33: 7839-7842. DOI: 10.1016/S0040-4039(00)74757-5  1
1975 Posner GH, Sterling JJ, Whitten CE, Lentz CM, Brunelle DJ. Alkylation of enolate ions generated regiospecifically via organocopper reactions. Synthesis of decalin sesquiterpene valerane and of prostaglandin model systems. Journal of the American Chemical Society. 97: 107-18. PMID 1133327  1
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