| Year |
Citation |
Score |
| 2016 |
Fox JM, Moynihan JR, Mott BT, Mazzone JR, Anders NM, Brown PA, Rudek MA, Liu JO, Arav-Boger R, Posner GH, Civin CI, Chen X. Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs. Oncotarget. PMID 26771236 DOI: 10.18632/Oncotarget.6896 |
0.66 |
|
| 2016 |
Conyers RC, Mazzone JR, Siegler MA, Posner GH. Highly regiocontrolled and stereocontrolled syntheses of polysubstituted aminocyclohexanes: mild inverse-electron-demand Diels–Alder cycloadditions of electrophilic 2-pyridones Tetrahedron Letters. 57: 3344-3348. DOI: 10.1016/J.Tetlet.2016.06.068 |
0.374 |
|
| 2016 |
Posner GH, Hatcher MA, Maio WA. Copper and silicon mediated, HMPA-free, n+3 ring expansions for the construction of medium sized lactones and lactams: short synthesis of (+)-cis-lauthisan Tetrahedron. 72: 6025-6030. DOI: 10.1016/J.Tet.2016.05.063 |
0.795 |
|
| 2016 |
Genna DT, Posner GH. Direct conversion of cinnamate esters into β,β-disubstituted ketones mediated by cyano-magnesio cuprates Tetrahedron. 72: 5968-5971. DOI: 10.1016/J.Tet.2016.05.003 |
0.333 |
|
| 2015 |
Conyers RC, Mazzone JR, Tripathi AK, Sullivan DJ, Posner GH. Antimalarial chemotherapy: orally curative artemisinin-derived trioxane dimer esters. Bioorganic & Medicinal Chemistry Letters. 25: 245-8. PMID 25481079 DOI: 10.1016/J.Bmcl.2014.11.064 |
0.338 |
|
| 2014 |
Schultz TL, Hencken CP, Woodard LE, Posner GH, Yolken RH, Jones-Brando L, Carruthers VB. A thiazole derivative of artemisinin moderately reduces Toxoplasma gondii cyst burden in infected mice. The Journal of Parasitology. 100: 516-21. PMID 24524228 DOI: 10.1645/13-451.1 |
0.778 |
|
| 2014 |
Conyers RC, Mazzone JR, Siegler MA, Tripathi AK, Sullivan DJ, Mott BT, Posner GH. The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether. Bioorganic & Medicinal Chemistry Letters. 24: 1285-9. PMID 24508128 DOI: 10.1016/J.Bmcl.2014.01.059 |
0.677 |
|
| 2013 |
He R, Forman M, Mott BT, Venkatadri R, Posner GH, Arav-Boger R. Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety Antimicrobial Agents and Chemotherapy. 57: 4208-4214. PMID 23774439 DOI: 10.1128/Aac.00893-13 |
0.681 |
|
| 2013 |
Mott BT, He R, Chen X, Fox JM, Civin CI, Arav-Boger R, Posner GH. Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study. Bioorganic & Medicinal Chemistry. 21: 3702-7. PMID 23673218 DOI: 10.1016/J.Bmc.2013.04.027 |
0.663 |
|
| 2013 |
Mott BT, Tripathi A, Siegler MA, Moore CD, Sullivan DJ, Posner GH. Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs. Journal of Medicinal Chemistry. 56: 2630-41. PMID 23425037 DOI: 10.1021/Jm400058J |
0.683 |
|
| 2013 |
Slack RD, Siegler MA, Posner GH. Highly stereocontrolled and regiocontrolled syntheses of polyoxygenated [2.2.2]oxabicyclic synthons Tetrahedron Letters. 54: 6267-6270. DOI: 10.1016/J.Tetlet.2013.09.030 |
0.711 |
|
| 2012 |
Mott BT, Cheng KC, Guha R, Kommer VP, Williams DL, Vermeire JJ, Cappello M, Maloney DJ, Rai G, Jadhav A, Simeonov A, Inglese J, Posner GH, Thomas CJ. A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases(). Medchemcomm. 3: 1505-1511. PMID 23205265 DOI: 10.1039/C2Md20238G |
0.653 |
|
| 2012 |
Jacobine AM, Mazzone JR, Slack RD, Tripathi AK, Sullivan DJ, Posner GH. Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose. Journal of Medicinal Chemistry. 55: 7892-9. PMID 22891714 DOI: 10.1021/Jm3009986 |
0.714 |
|
| 2012 |
He R, Park K, Cai H, Kapoor A, Forman M, Mott B, Posner GH, Arav-Boger R. Artemisinin-derived dimer diphenyl phosphate is an irreversible inhibitor of human cytomegalovirus replication Antimicrobial Agents and Chemotherapy. 56: 3508-3515. PMID 22547612 DOI: 10.1128/Aac.00519-12 |
0.657 |
|
| 2012 |
Slack RD, Mott BT, Woodard LE, Tripathi A, Triphati A, Sullivan D, Nenortas E, Girdwood SC, Shapiro TA, Posner GH. Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine. Journal of Medicinal Chemistry. 55: 291-6. PMID 22128829 DOI: 10.1021/Jm201214D |
0.782 |
|
| 2012 |
Slack RD, Jacobine AM, Posner GH. Antimalarial peroxides: Advances in drug discovery and design Medchemcomm. 3: 281-297. DOI: 10.1039/C2Md00277A |
0.722 |
|
| 2012 |
Slack RD, Mott BT, Woodard LE, Tripathi A, Sullivan D, Nenortas E, Girdwood SCT, Shapiro TA, Posner GH. Correction to Malaria-Infected Mice Are Completely Cured by One 6 mg/kg Oral Dose of a New Monomeric Trioxane Sulfide Combined with Mefloquine Journal of Medicinal Chemistry. 55: 1788-1788. DOI: 10.1021/Jm300104M |
0.776 |
|
| 2011 |
He R, Mott BT, Rosenthal AS, Genna DT, Posner GH, Arav-Boger R. An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activities Plos One. 6. PMID 21904628 DOI: 10.1371/Journal.Pone.0024334 |
0.791 |
|
| 2011 |
Genna DT, Posner GH. Cyanocuprates convert carboxylic acids directly into ketones. Organic Letters. 13: 5358-61. PMID 21894954 DOI: 10.1021/Ol202237J |
0.756 |
|
| 2011 |
Jacobine AM, Posner GH. Three-component, one-flask synthesis of rhodanines (thiazolidinones) Journal of Organic Chemistry. 76: 8121-8125. PMID 21853986 DOI: 10.1021/Jo201561T |
0.373 |
|
| 2011 |
Somjen D, Katzburg S, Sharon O, Posner GH, Jaccard N, Hendel D, Tamir S, Vaya J. Mutual interaction of special phytoestrogenic compounds, their synthetic carboxy-derivatives and the less-calcemic vitamin D analog activities in human derived female cultured osteoblasts Journal of Steroid Biochemistry and Molecular Biology. 127: 351-357. PMID 21810473 DOI: 10.1016/J.Jsbmb.2011.07.003 |
0.322 |
|
| 2011 |
Hencken CP, Genna DT, Siegler MA, Posner GH. Highly stereocontrolled and regiocontrolled syntheses of 2,3,4-trisubstituted alkanoates and lactones. The Journal of Organic Chemistry. 76: 5149-55. PMID 21563766 DOI: 10.1021/Jo200795F |
0.804 |
|
| 2011 |
Somjen D, Katzburg S, Grafi-Cohen M, Knoll E, Sharon O, Posner GH. Vitamin D metabolites and analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cell line Journal of Steroid Biochemistry and Molecular Biology. 123: 85-89. PMID 21111046 DOI: 10.1016/J.Jsbmb.2010.11.010 |
0.318 |
|
| 2011 |
Moon DK, Tripathi A, Sullivan D, Siegler MA, Parkin S, Posner GH. A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice. Bioorganic & Medicinal Chemistry Letters. 21: 2773-5. PMID 20952197 DOI: 10.1016/J.Bmcl.2010.09.123 |
0.304 |
|
| 2011 |
Genna DT, Posner GH. Cyanocuprates convert carboxylic acids directly into ketones Organic Letters. 13: 5358-5361. DOI: 10.1021/ol202237j |
0.721 |
|
| 2011 |
Posner GH. Substitution Reactions Using Organocopper Reagents Organic Reactions. 253-400. DOI: 10.1002/0471264180.Or022.02 |
0.342 |
|
| 2011 |
Posner GH. Conjugate Addition Reactions of Organocopper Reagents Organic Reactions. 1-114. DOI: 10.1002/0471264180.Or019.01 |
0.357 |
|
| 2010 |
Genna DT, Hencken CP, Siegler MA, Posner GH. α-Chloro-β,γ-ethylenic esters: enantiocontrolled synthesis and substitutions. Organic Letters. 12: 4694-7. PMID 20853879 DOI: 10.1021/Ol102142A |
0.797 |
|
| 2010 |
Arav-Boger R, He R, Chiou CJ, Liu J, Woodard L, Rosenthal A, Jones-Brando L, Forman M, Posner G. Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomers Plos One. 5. PMID 20442781 DOI: 10.1371/Journal.Pone.0010370 |
0.601 |
|
| 2010 |
Hess LC, Posner GH. Asymmetric, organocatalytic, three-step synthesis of alpha-hydroxy-(E)-beta,gamma-unsaturated esters. Organic Letters. 12: 2120-2. PMID 20377201 DOI: 10.1021/Ol100615J |
0.792 |
|
| 2010 |
Hencken CP, Jones-Brando L, Bordón C, Stohler R, Mott BT, Yolken R, Posner GH, Woodard LE. Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondii. Journal of Medicinal Chemistry. 53: 3594-601. PMID 20373807 DOI: 10.1021/Jm901857D |
0.783 |
|
| 2010 |
Posner GH, Helvig C, Cuerrier D, Collop D, Kharebov A, Ryder K, Epps T, Petkovich M. Vitamin D analogues targeting CYP24 in chronic kidney disease Journal of Steroid Biochemistry and Molecular Biology. 121: 13-19. PMID 20347976 DOI: 10.1016/J.Jsbmb.2010.03.065 |
0.303 |
|
| 2010 |
Hess LC, Posner GH. ChemInform Abstract: Asymmetric, Organocatalytic, Three-Step Synthesis of α-Hydroxy-(E)-β,γ-unsaturated Esters. Cheminform. 41: no-no. DOI: 10.1002/chin.201037063 |
0.788 |
|
| 2009 |
Woodard LE, Mott BT, Singhal V, Kumar N, Shapiro TA, Posner GH. Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine. Pharmaceuticals (Basel, Switzerland). 2: 228-235. PMID 27713236 DOI: 10.3390/Ph2030228 |
0.67 |
|
| 2009 |
Moon DK, Singhal V, Kumar N, Shapiro TA, Posner GH. Antimalarial Preclinical Drug Development: A Single Oral Dose of A 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice. Drug Development Research. 71: 76-81. PMID 20686674 DOI: 10.1002/Ddr.20350 |
0.339 |
|
| 2009 |
Woodard LE, Chang W, Chen X, Liu JO, Shapiro TA, Posner GH. Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose Journal of Medicinal Chemistry. 52: 7458-7462. PMID 19586052 DOI: 10.1021/Jm9005934 |
0.307 |
|
| 2009 |
Usera AR, Dolan P, Kensler TW, Posner GH. 'Novel alkyl side chain sulfone 1α,25-dihydroxyvitamin D3 analogs: A comparison of in vitro antiproliferative activities and in vivo calcemic activities' Bioorganic and Medicinal Chemistry. 17: 5627-5631. PMID 19577932 DOI: 10.1016/J.Bmc.2009.06.033 |
0.802 |
|
| 2009 |
Rosenthal AS, Chen X, Liu JO, West DC, Hergenrother PJ, Shapiro TA, Posner GH. Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells. Journal of Medicinal Chemistry. 52: 1198-203. PMID 19186946 DOI: 10.1021/Jm801484V |
0.594 |
|
| 2009 |
Hartwig CL, Rosenthal AS, D'Angelo J, Griffin CE, Posner GH, Cooper RA. Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent Biochemical Pharmacology. 77: 322-336. PMID 19022224 DOI: 10.1016/J.Bcp.2008.10.015 |
0.559 |
|
| 2009 |
D'Angelo JG, Bordón C, Posner GH, Yolken R, Jones-Brando L. Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle. The Journal of Antimicrobial Chemotherapy. 63: 146-50. PMID 18988681 DOI: 10.1093/Jac/Dkn451 |
0.339 |
|
| 2009 |
Jeon HB, Posner GH. New A-ring analogs of the hormone 1α,25-dihydroxyvitamin D3: (2′-hydroxymethyl)tetrahydrofuro[1,2-a]-25-hydroxyvitamin D3 Tetrahedron. 65: 1235-1240. DOI: 10.1016/J.Tet.2008.12.034 |
0.399 |
|
| 2008 |
Petersen KS, Posner GH. Asymmetric, organocatalytic, three-step synthesis of γ-hydroxy-(E)- α,β-unsaturated sulfones and esters Organic Letters. 10: 4685-4687. PMID 18811178 DOI: 10.1021/Ol8020513 |
0.681 |
|
| 2008 |
Posner GH, Maio WA, Kalinda AS. Electronically stabilized versions of the antimalarial acetal trioxanes artemether and artesunate Bioorganic and Medicinal Chemistry. 16: 5247-5253. PMID 18353653 DOI: 10.1016/J.Bmc.2008.03.010 |
0.781 |
|
| 2008 |
Posner GH, Chang W, Hess L, Woodard L, Sinishtaj S, Usera AR, Maio W, Rosenthal AS, Kalinda AS, D'Angelo JG, Petersen KS, Stohler R, Chollet J, Santo-Tomas J, Snyder C, et al. Malaria-infected mice are cured by oral administration of new artemisinin derivatives. Journal of Medicinal Chemistry. 51: 1035-42. PMID 18232653 DOI: 10.1021/Jm701168H |
0.754 |
|
| 2007 |
Petersen KS, Dolan PM, Kensler TW, Peleg S, Posner GH. Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Medicinal Chemistry. 50: 5824-5832. PMID 17924616 DOI: 10.1021/Jm070882D |
0.684 |
|
| 2007 |
Zhang J, Posner GH, Danilenko M, Studzinski GP. Differentiation-inducing potency of the seco-steroid JK-1624F2-2 can be increased by combination with an antioxidant and a p38MAPK inhibitor which upregulates the JNK pathway Journal of Steroid Biochemistry and Molecular Biology. 105: 140-149. PMID 17583492 DOI: 10.1016/J.Jsbmb.2007.01.003 |
0.306 |
|
| 2007 |
Maio WA, Sinishtaj S, Posner GH. Cyclopentanone ring expansion leading to functionalized delta-lactams: short synthesis of simple sedum alkaloids. Organic Letters. 9: 2673-6. PMID 17564459 DOI: 10.1021/Ol070960R |
0.799 |
|
| 2007 |
Usera AR, Dolan PM, Kensler TW, Posner GH. Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1α,25-dihydroxyvitamin D3: Chemical synthesis and biological evaluation Bioorganic and Medicinal Chemistry. 15: 5509-5518. PMID 17560112 DOI: 10.1016/J.Bmc.2007.05.051 |
0.815 |
|
| 2007 |
Posner GH, Paik IH, Chang W, Borstnik K, Sinishtaj S, Rosenthal AS, Shapiro TA. Malaria-infected mice are cured by a single dose of novel artemisinin derivatives Journal of Medicinal Chemistry. 50: 2516-2519. PMID 17439113 DOI: 10.1021/Jm070149M |
0.775 |
|
| 2007 |
Usera AR, Posner GH. Unexpected steric effects of "remote" alkyl groups on the rate of conjugate additions to alkyl α,β-ethylenic sulfones, sulfoxides, and esters Journal of Organic Chemistry. 72: 2329-2334. PMID 17341116 DOI: 10.1021/Jo062155G |
0.791 |
|
| 2007 |
Alagbala AA, Johnson CS, Trump DL, Posner GH, Foster BA. Antitumor effects of two less-calcemic vitamin D analogs (paricalcitol and QW-1624F2-2) in squamous cell carcinoma cells Oncology. 70: 483-492. PMID 17237623 DOI: 10.1159/000098813 |
0.315 |
|
| 2007 |
Posner GH, Suh BC, Petersen KS, Dolan P, Agoston ES, Kensler TW, Koh JT, Peleg S. Difluoromethyl analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Steroid Biochemistry and Molecular Biology. 103: 213-221. PMID 17218093 DOI: 10.1016/J.Jsbmb.2006.12.024 |
0.757 |
|
| 2007 |
Lechner D, Manhardt T, Bajna E, Posner GH, Cross HS. A 24-phenylsulfone analog of vitamin D inhibits 1α,25- dihydroxyvitamin D3 degradation in vitamin D metabolism-competent cells Journal of Pharmacology and Experimental Therapeutics. 320: 1119-1126. PMID 17182978 DOI: 10.1124/Jpet.106.115451 |
0.317 |
|
| 2007 |
Maio WA, Sinishtaj S, Posner GH. Cyclopentanone ring expansion leading to functionalized δ-lactams: Short synthesis of simple sedum alkaloids Organic Letters. 9: 2673-2676. DOI: 10.1021/ol070960r |
0.793 |
|
| 2007 |
Hatcher MA, Posner GH. The Carroll Rearrangement The Claisen Rearrangement: Methods and Applications. 397-430. DOI: 10.1002/9783527610549.ch8 |
0.716 |
|
| 2006 |
Alagbala AA, McRiner AJ, Borstnik K, Labonte T, Chang W, D'Angelo JG, Posner GH, Foster BA. Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines Journal of Medicinal Chemistry. 49: 7836-7842. PMID 17181166 DOI: 10.1021/Jm060803I |
0.766 |
|
| 2006 |
Peleg S, Petersen KS, Suh BC, Dolan P, Agoston ES, Kensler TW, Posner GH. Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Medicinal Chemistry. 49: 7513-7517. PMID 17149880 DOI: 10.1021/Jm0609925 |
0.745 |
|
| 2006 |
Sinishtaj S, Jeon HB, Dolan P, Kensler TW, Posner GH. Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1α,25-dihydroxyvitamin D3 Bioorganic and Medicinal Chemistry. 14: 6341-6348. PMID 16765598 DOI: 10.1016/J.Bmc.2006.05.050 |
0.798 |
|
| 2006 |
Paik IH, Xie S, Shapiro TA, Labonte T, Narducci Sarjeant AA, Baege AC, Posner GH. Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity Journal of Medicinal Chemistry. 49: 2731-2734. PMID 16640333 DOI: 10.1021/Jm058288W |
0.352 |
|
| 2006 |
Agoston ES, Hatcher MA, Kensler TW, Posner GH. Vitamin D analogs as anti-carcinogenic agents Anti-Cancer Agents in Medicinal Chemistry. 6: 53-71. PMID 16475927 DOI: 10.2174/187152006784111369 |
0.737 |
|
| 2006 |
Reddy CD, Patti R, Guttapalli A, Maris JM, Yanamandra N, Rachamallu A, Sutton LN, Phillips PC, Posner GH. Anticancer effects of the novel 1alpha, 25-dihydroxyvitamin D3 hybrid analog QW1624F2-2 in human neuroblastoma. Journal of Cellular Biochemistry. 97: 198-206. PMID 16200638 DOI: 10.1002/Jcb.20629 |
0.314 |
|
| 2006 |
Posner GH, D'Angelo J, O'Neill PM, Mercer A. Anticancer activity of artemisinin-derived trioxanes Expert Opinion On Therapeutic Patents. 16: 1665-1672. DOI: 10.1517/13543776.16.12.1665 |
0.316 |
|
| 2006 |
Kim J, Li HB, Rosenthal AS, Sang D, Shapiro TA, Bachi MD, Posner GH. Ground state oxygen in synthesis of cyclic peroxides. Part 1: Benzo fused ketals Tetrahedron. 62: 4120-4127. DOI: 10.1016/J.Tet.2006.02.008 |
0.608 |
|
| 2005 |
O'Neill PM, Rawe SL, Borstnik K, Miller A, Ward SA, Bray PG, Davies J, Oh CH, Posner GH. Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins. Chembiochem : a European Journal of Chemical Biology. 6: 2048-54. PMID 16222725 DOI: 10.1002/Cbic.200500048 |
0.779 |
|
| 2005 |
Posner GH, Hatcher MA, Maio WA. New silicon-mediated, sequential ring expansions of n-sized 2-cycloalkenones into hydroxyolefinic n + m + p medium-sized lactones: short synthesis of (-)-phoracantholide-J. Organic Letters. 7: 4301-3. PMID 16146412 DOI: 10.1021/Ol051854X |
0.793 |
|
| 2005 |
Posner GH, Hyung JK, Kahraman M, Heung BJ, Byung CS, Li H, Dolan P, Kensler TW. Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1α,25-dihydroxyvitamin D3 Bioorganic and Medicinal Chemistry. 13: 5569-5580. PMID 16039132 DOI: 10.1016/J.Bmc.2005.06.031 |
0.584 |
|
| 2005 |
Dixon KM, Deo SS, Wong G, Slater M, Norman AW, Bishop JE, Posner GH, Ishizuka S, Halliday GM, Reeve VE, Mason RS. Skin cancer prevention: A possible role of 1,25dihydroxyvitamin D3 and its analogs Journal of Steroid Biochemistry and Molecular Biology. 97: 137-143. PMID 16039116 DOI: 10.1016/J.Jsbmb.2005.06.006 |
0.312 |
|
| 2005 |
Hatcher MA, Peleg S, Dolan P, Kensler TW, Sarjeant A, Posner GH. A-ring hydroxymethyl 19-nor analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Synthesis and preliminary biological evaluation Bioorganic and Medicinal Chemistry. 13: 3964-3976. PMID 15878279 DOI: 10.1016/J.Bmc.2005.04.010 |
0.741 |
|
| 2005 |
Posner GH, Lee SHT, Kim HJ, Peleg S, Dolan P, Kensler TW. Novel A-ring analogs of the hormone 1α,25-dihydroxyvitamin D 3: Synthesis and preliminary biological evaluation Bioorganic and Medicinal Chemistry. 13: 2959-2966. PMID 15781405 DOI: 10.1016/J.Bmc.2005.02.005 |
0.397 |
|
| 2005 |
Posner GH, Hatcher MA, Maio WA. New silicon-mediated, sequential ring expansions of n-sized 2-cycloalkenones into hydroxyolefinic n + m + p medium-sized lactones: Short synthesis of (-)-phoracantholide-J Organic Letters. 7: 4301-4303. DOI: 10.1021/ol051854x |
0.775 |
|
| 2005 |
O'Neill PM, Rawe SL, Storr RC, Ward SA, Posner GH. Lewis acid catalysed rearrangements of unsaturated bicyclic [2.2.n] endoperoxides in the presence of vinyl silanes; access to novel Fenozan BO-7 analogues Tetrahedron Letters. 46: 3029-3032. DOI: 10.1016/J.Tetlet.2005.03.022 |
0.582 |
|
| 2005 |
Posner GH, Kahraman M. Overview: Rational Design of 1α,25-Dihydroxyvitamin D3 Analogs (Deltanoids) Vitamin D. 2: 1405-1422. DOI: 10.1016/B978-012252687-9/50084-X |
0.491 |
|
| 2004 |
Kahraman M, Sinishtaj S, Dolan PM, Kensler TW, Peleg S, Saha U, Chuang SS, Bernstein G, Korczak B, Posner GH. Potent, selective and low-calcemic inhibitors of CYP24 Hydroxylase: 24-Sulfoximine analogues of the hormone 1α,25-dihydroxyvitamin D 3 Journal of Medicinal Chemistry. 47: 6854-6863. PMID 15615534 DOI: 10.1021/Jm040129+ |
0.791 |
|
| 2004 |
Posner GH, Jeon HB, Sarjeant A, Riccio ES, Doppalapudi RS, Kapetanovic IM, Saha U, Dolan P, Kensler TW. Low-calcemic, efficacious, 1α,25-dihydroxyvitamin D 3 analog QW-1624F 2-2: Calcemic dose-response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry Steroids. 69: 757-762. PMID 15579327 DOI: 10.1016/J.Steroids.2004.09.004 |
0.335 |
|
| 2004 |
Posner GH, Crawford KR, Yang HW, Kahraman M, Jeon HB, Li H, Lee JK, Suh BC, Hatcher MA, Labonte T, Usera A, Dolan PM, Kensler TW, Peleg S, Jones G, et al. Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-Sulfone analogs of the hormone 1α,25-dihydroxyvitamin D3 Journal of Steroid Biochemistry and Molecular Biology. 89: 5-12. PMID 15225738 DOI: 10.1016/J.Jsbmb.2004.03.044 |
0.781 |
|
| 2004 |
Posner GH, O'Neill PM. Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides Accounts of Chemical Research. 37: 397-404. PMID 15196049 DOI: 10.1021/Ar020227U |
0.543 |
|
| 2004 |
O'Neill PM, Posner GH. A medicinal chemistry perspective on artemisinin and related endoperoxides Journal of Medicinal Chemistry. 47: 2945-2964. PMID 15163175 DOI: 10.1021/Jm030571C |
0.476 |
|
| 2004 |
Posner GH, McRiner AJ, Paik IH, Sur S, Borstnik K, Xie S, Shapiro TA, Alagbala A, Foster B. Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents. Journal of Medicinal Chemistry. 47: 1299-301. PMID 14971910 DOI: 10.1021/Jm0303711 |
0.791 |
|
| 2004 |
Jeyadevan JP, Bray PG, Chadwick J, Mercer AE, Byrne A, Ward SA, Park BK, Williams DP, Cosstick R, Davies J, Higson AP, Irving E, Posner GH, O'Neill PM. Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin. Journal of Medicinal Chemistry. 47: 1290-8. PMID 14971909 DOI: 10.1021/Jm030974C |
0.572 |
|
| 2004 |
Suh BC, Jeon H, Posner GH, Silverman SM. Vitamin D side chain triazole analogs via cycloaddition 'click' chemistry Tetrahedron Letters. 45: 4623-4625. DOI: 10.1016/J.Tetlet.2004.04.118 |
0.718 |
|
| 2004 |
Suh B, Jeon H, Posner GH, Silverman SM. Vitamin D Side Chain Triazole Analogues via Cycloaddition ′Click′ Chemistry. Cheminform. 35. DOI: 10.1002/chin.200438209 |
0.575 |
|
| 2003 |
Peleg S, Posner GH. Vitamin D analogs as modulators of vitamin D receptor action. Current Topics in Medicinal Chemistry. 3: 1555-1572. PMID 14683515 DOI: 10.2174/1568026033451691 |
0.301 |
|
| 2003 |
Bachi MD, Korshin EE, Hoos R, Szpilman AM, Ploypradith P, Xie S, Shapiro TA, Posner GH. A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides. Journal of Medicinal Chemistry. 46: 2516-33. PMID 12773055 DOI: 10.1021/Jm020584A |
0.645 |
|
| 2003 |
Posner GH, Maxwell JP, Kahraman M. Mild, fast, and stereoselective epoxide opening by ketone enolate anions. Application to synthesis of the norlignan curculigine. The Journal of Organic Chemistry. 68: 3049-54. PMID 12688771 DOI: 10.1021/Jo020744Q |
0.734 |
|
| 2003 |
Posner GH, Paik IH, Sur S, McRiner AJ, Borstnik K, Xie S, Shapiro TA. Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy. Journal of Medicinal Chemistry. 46: 1060-5. PMID 12620083 DOI: 10.1021/Jm020461Q |
0.799 |
|
| 2003 |
Hatcher MA, Borstnik K, Posner GH. New silicon-mediated ring expansion of n-sized conjugated cycloalkenones into homoallylic n+3 lactones Tetrahedron Letters. 44: 5407-5409. DOI: 10.1016/S0040-4039(03)01308-X |
0.796 |
|
| 2003 |
Posner GH, Kahraman M. Organic Chemistry of Vitamin D Analogues (Deltanoids) European Journal of Organic Chemistry. 3889-3895. DOI: 10.1002/Ejoc.200300264 |
0.585 |
|
| 2003 |
Webb KS, Asirvatham E, Posner GH. A General Method for the Preparation of 9‐, 10‐, and 11‐Membered Unsaturated Macrolides: Synthesis of 8‐Propionyl‐(E)‐5‐Nonenolide Organic Syntheses. 188-188. DOI: 10.1002/0471264180.Os069.23 |
0.336 |
|
| 2003 |
Hulce M, Mallomo JP, Frye LL, Kogan TP, Posner GH. (S)‐( + )‐2‐(p‐Toluenesulfinyl)‐2‐Cyclopentenone: Precursor for Enantioselective Synthesis of 3‐Substituted Cyclopentanones Organic Syntheses. 196-196. DOI: 10.1002/0471264180.Os064.29 |
0.754 |
|
| 2003 |
Posner GH, Whitten CE. Secondary and Tertiary Alkyl Ketones from Carboxylic Acid Chlorides and Lithium Phenylthio(Alkyl)Cuprate Reagents: tert‐Butyl Phenyl Ketone Organic Syntheses. 122-122. DOI: 10.1002/0471264180.Os055.28 |
0.341 |
|
| 2002 |
Borstnik K, Paik IH, Shapiro TA, Posner GH. Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds. International Journal For Parasitology. 32: 1661-7. PMID 12435451 DOI: 10.1016/S0020-7519(02)00195-9 |
0.786 |
|
| 2002 |
Borstnik K, Paik IH, Posner GH. Malaria: new chemotherapeutic peroxide drugs. Mini Reviews in Medicinal Chemistry. 2: 573-83. PMID 12370042 DOI: 10.2174/1389557023405620 |
0.774 |
|
| 2002 |
Carreño MC, Ribagorda M, Posner GH. Titanium-promoted stereoselective synthesis of hydroindolones from p-quinamines by domino conjugate additions. Angewandte Chemie (International Ed. in English). 41: 2753-5. PMID 12203474 DOI: 10.1002/1521-3773(20020802)41:15<2753::Aid-Anie2753>3.0.Co;2-M |
0.329 |
|
| 2002 |
Posner GH, Jeon HB, Ploypradith P, Paik IH, Borstnik K, Xie S, Shapiro TA. Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents. Journal of Medicinal Chemistry. 45: 3824-8. PMID 12190305 DOI: 10.1021/Jm020210H |
0.796 |
|
| 2002 |
Posner GH, Woodard BT, Crawford KR, Peleg S, Brown AJ, Dolan P, Kensler TW. 2,2-Disubstituted analogues of the natural hormone 1 alpha,25-dihydroxyvitamin D(3): chemistry and biology. Bioorganic & Medicinal Chemistry. 10: 2353-65. PMID 11983533 DOI: 10.1016/S0968-0896(02)00058-5 |
0.794 |
|
| 2002 |
Posner GH, Halford BA, Peleg S, Dolan P, Kensler TW. Conceptually new low-calcemic oxime analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): synthesis and biological testing. Journal of Medicinal Chemistry. 45: 1723-30. PMID 11931627 DOI: 10.1021/Jm010560O |
0.666 |
|
| 2002 |
Posner GH, Northrop J, Paik IH, Borstnik K, Dolan P, Kensler TW, Xie S, Shapiro TA. New chemical and biological aspects of artemisinin-derived trioxane dimers. Bioorganic & Medicinal Chemistry. 10: 227-32. PMID 11738625 DOI: 10.1016/S0968-0896(01)00270-X |
0.79 |
|
| 2002 |
Hatcher MA, Posner GH. [3,3]-Sigmatropic rearrangements: Short, stereocontrolled syntheses of functionalized vitamin D3 side-chain units Tetrahedron Letters. 43: 5009-5012. DOI: 10.1016/S0040-4039(02)00904-8 |
0.747 |
|
| 2002 |
Korshin EE, Hoos R, Szpilman AM, Konstantinovski L, Posner GH, Bachi MD. An efficient synthesis of bridged-bicyclic peroxides structurally related to antimalarial yingzhaosu A based on radical co-oxygenation of thiols and monoterpenes Tetrahedron. 58: 2449-2469. DOI: 10.1016/S0040-4020(02)00126-6 |
0.319 |
|
| 2001 |
Posner GH, Crawford KR, Peleg S, Welsh JE, Romu S, Gewirtz DA, Gupta MS, Dolan P, Kensler TW. A non-calcemic sulfone version of the vitamin D(3) analogue seocalcitol (EB 1089): chemical synthesis, biological evaluation and potency enhancement of the anticancer drug adriamycin. Bioorganic & Medicinal Chemistry. 9: 2365-71. PMID 11553477 DOI: 10.1016/S0968-0896(01)00159-6 |
0.76 |
|
| 2001 |
Posner GH, Jeon HB, Parker MH, Krasavin M, Paik IH, Shapiro TA. Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents. Journal of Medicinal Chemistry. 44: 3054-8. PMID 11543673 DOI: 10.1021/Jm0102396 |
0.533 |
|
| 2001 |
Somjen D, Waisman A, Lee JK, Posner GH, Kaye AM. A non-calcemic analog of 1 alpha,25 dihydroxy vitamin D(3) (JKF) upregulates the induction of creatine kinase B by 17 beta estradiol in osteoblast-like ROS 17/2.8 cells and in rat diaphysis. The Journal of Steroid Biochemistry and Molecular Biology. 77: 205-12. PMID 11457658 DOI: 10.1016/S0960-0760(01)00065-6 |
0.322 |
|
| 2001 |
White MC, Burke MD, Peleg S, Brem H, Posner GH. Conformationally restricted hybrid analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): design, synthesis, and biological evaluation. Bioorganic & Medicinal Chemistry. 9: 1691-9. PMID 11425569 DOI: 10.1016/S0968-0896(01)00087-6 |
0.698 |
|
| 2001 |
Guyton KZ, Kensler TW, Posner GH. Cancer chemoprevention using natural vitamin D and synthetic analogs. Annual Review of Pharmacology and Toxicology. 41: 421-42. PMID 11264464 DOI: 10.1146/Annurev.Pharmtox.41.1.421 |
0.306 |
|
| 2001 |
Weiskopf AS, Vouros P, Cunniff J, Binderup E, Björkling F, Binderup L, White MC, Posner GH. Examination of structurally selective derivatization of vitamin D(3) analogues by electrospray mass spectrometry. Journal of Mass Spectrometry : Jms. 36: 71-8. PMID 11180648 DOI: 10.1002/Jms.105 |
0.524 |
|
| 2001 |
Kadiyala S, Nagaba S, Takeuchi K, Yukihiro S, Qiu W, Eyes ST, Uskokovic MR, Posner GH, Reddy GS, Guggino SE. Metabolites and analogs of 1alpha,25-dihydroxyvitamin D(3): evaluation of actions in bone. Steroids. 66: 347-55. PMID 11179743 DOI: 10.1016/S0039-128X(00)00167-7 |
0.317 |
|
| 2001 |
O'Neill PM, Miller A, Bishop LP, Hindley S, Maggs JL, Ward SA, Roberts SM, Scheinmann F, Stachulski AV, Posner GH, Park BK. Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin. Journal of Medicinal Chemistry. 44: 58-68. PMID 11141088 DOI: 10.1021/jm000987f |
0.527 |
|
| 2000 |
Posner GH, Crawford K, Siu-Caldera ML, Reddy GS, Sarabia SF, Feldman D, van Etten E, Mathieu C, Gennaro L, Vouros P, Peleg S, Dolan PM, Kensler TW. Conceptually new 20-epi-22-oxa sulfone analogues of the hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and biological evaluation. Journal of Medicinal Chemistry. 43: 3581-6. PMID 11000014 DOI: 10.1021/Jm000215J |
0.748 |
|
| 2000 |
Posner GH, Maxwell JP, O'Dowd H, Krasavin M, Xie S, Shapiro TA. Antimalarial sulfide, sulfone, and sulfonamide trioxanes. Bioorganic & Medicinal Chemistry. 8: 1361-70. PMID 10896113 DOI: 10.1016/S0968-0896(00)00079-1 |
0.635 |
|
| 2000 |
Kensler TW, Dolan PM, Gange SJ, Lee JK, Wang Q, Posner GH. Conceptually new deltanoids (vitamin D analogs) inhibit multistage skin tumorigenesis. Carcinogenesis. 21: 1341-5. PMID 10874012 DOI: 10.1093/Carcin/21.5.341 |
0.378 |
|
| 2000 |
Posner GH, Wang Q, Halford BA, Elias JS, Maxwell JP. New synthetic methodology for ring expansion of n-sized conjugated cycloalkenones into homoallylic n+3 lactones: Three-step synthesis of fragrant phoracantholide Tetrahedron Letters. 41: 9655-9659. DOI: 10.1016/S0040-4039(00)01739-1 |
0.796 |
|
| 1999 |
Posner GH, Ploypradith P, Parker MH, O'Dowd H, Woo SH, Northrop J, Krasavin M, Dolan P, Kensler TW, Xie S, Shapiro TA. Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers. Journal of Medicinal Chemistry. 42: 4275-80. PMID 10543871 DOI: 10.1021/Jm990363D |
0.719 |
|
| 1999 |
Hofer H, Ho Gm, Peterlik M, Uskokovic MR, Lee JK, White MC, Posner GH, Cross HS. Biological effects of 1alpha-hydroxy- and 1beta-(hydroxymethyl)-vitamin D compounds relevant for potential colorectal cancer therapy. The Journal of Pharmacology and Experimental Therapeutics. 291: 450-5. PMID 10525058 |
0.484 |
|
| 1999 |
Posner GH, Wang Q, Han G, Lee JK, Crawford K, Zand S, Brem H, Peleg S, Dolan P, Kensler TW. Conceptually new sulfone analogues of the hormone 1alpha, 25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation. Journal of Medicinal Chemistry. 42: 3425-35. PMID 10479276 DOI: 10.1021/Jm990267C |
0.746 |
|
| 1999 |
Pedrozo HA, Schwartz Z, Rimes S, Sylvia VL, Nemere I, Posner GH, Dean DD, Boyan BD. Physiological importance of the 1,25(OH)2D3 membrane receptor and evidence for a membrane receptor specific for 24,25(OH)2D3. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 14: 856-67. PMID 10352093 DOI: 10.1359/Jbmr.1999.14.6.856 |
0.304 |
|
| 1999 |
Posner GH, Parker MH, Northrop J, Elias JS, Ploypradith P, Xie S, Shapiro TA. Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family. Journal of Medicinal Chemistry. 42: 300-4. PMID 9925735 DOI: 10.1021/Jm980529V |
0.795 |
|
| 1999 |
O' Neill PM, Miller A, Bickley JF, Scheinmann F, Oh CH, Posner GH. Asymmetric syntheses of enantiomeric 3-p-fluorophenyl 1,2,4-trioxane analogues of the antimalarial artemisinin Tetrahedron Letters. 40: 9133-9136. DOI: 10.1016/S0040-4039(99)01892-4 |
0.338 |
|
| 1999 |
O'Dowd H, Ploypradith P, Suji X, Shapiro TA, Posner GH. Antimalarial artemisinin analogs. Synthesis via chemoselective C-C bond formation and preliminary biological evaluation Tetrahedron. 55: 3625-3636. DOI: 10.1016/S0040-4020(98)01170-3 |
0.679 |
|
| 1998 |
Bachi MD, Korshin EE, Ploypradith P, Cumming JN, Xie S, Shapiro TA, Posner GH. Synthesis and in vitro antimalarial activity of sulfone endoperoxides. Bioorganic & Medicinal Chemistry Letters. 8: 903-8. PMID 9871509 DOI: 10.1016/S0960-894X(98)00141-3 |
0.672 |
|
| 1998 |
Posner GH, Lee JK, Wang Q, Peleg S, Burke M, Brem H, Dolan P, Kensler TW. Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1alpha, 25-dihydroxyvitamin D3. Synthesis and preliminary biological evaluation. Journal of Medicinal Chemistry. 41: 3008-14. PMID 9685240 DOI: 10.1021/Jm980031T |
0.602 |
|
| 1998 |
Posner GH, O'Dowd H, Ploypradith P, Cumming JN, Xie S, Shapiro TA. Antimalarial cyclic peroxy ketals. Journal of Medicinal Chemistry. 41: 2164-7. PMID 9622557 DOI: 10.1021/Jm980088F |
0.652 |
|
| 1998 |
van Lieshout EM, Posner GH, Woodard BT, Peters WH. Effects of the sulforaphane analog compound 30, indole-3-carbinol, D-limonene or relafen on glutathione S-transferases and glutathione peroxidase of the rat digestive tract. Biochimica Et Biophysica Acta. 1379: 325-36. PMID 9545594 DOI: 10.1016/S0304-4165(97)00112-8 |
0.777 |
|
| 1998 |
Peleg S, Nguyen C, Woodard BT, Lee JK, Posner GH. Differential use of transcription activation function 2 domain of the vitamin D receptor by 1,25-dihydroxyvitamin D3 and its A ring-modified analogs. Molecular Endocrinology (Baltimore, Md.). 12: 525-35. PMID 9544988 DOI: 10.1210/Mend.12.4.0083 |
0.788 |
|
| 1998 |
Cumming JN, Wang D, Park SB, Shapiro TA, Posner GH. Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin. Journal of Medicinal Chemistry. 41: 952-64. PMID 9526569 DOI: 10.1021/Jm970711G |
0.379 |
|
| 1998 |
Posner GH, Cumming JN, Woo SH, Ploypradith P, Xie S, Shapiro TA. Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation. Journal of Medicinal Chemistry. 41: 940-51. PMID 9526568 DOI: 10.1021/Jm970686E |
0.658 |
|
| 1998 |
O'Neill PM, Searle NL, Raynes KJ, Maggs JL, Ward SA, Storr RC, Park BK, Posner GH. A carbonyl oxide route to antimalarial Yingzhaosu A analogues: Synthesis and antimalarial activity Tetrahedron Letters. 39: 6065-6068. DOI: 10.1016/S0040-4039(98)01248-9 |
0.561 |
|
| 1998 |
Posner GH, O'Dowd H, Caferro T, Cumming JN, Ploypradith P, Xie S, Shapiro TA. Antimalarial sulfone trioxanes Tetrahedron Letters. 39: 2273-2276. DOI: 10.1016/S0040-4039(98)00290-1 |
0.637 |
|
| 1998 |
Woo SH, Parker MH, Ploypradith P, Northrop J, Posner GH. Direct conversion of pyranose anomeric OH→F→R in the artemisinin family of antimalarial trioxanes Tetrahedron Letters. 39: 1533-1536. DOI: 10.1016/S0040-4039(98)00132-4 |
0.72 |
|
| 1998 |
Crawford KR, Posner GH. A highly stereoselective pentannulation of prochiral cyclic enones using a chiral 1,3-dipole equivalent Chemtracts. 11: 561-564. |
0.708 |
|
| 1997 |
Posner GH, Lee JK, White MC, Hutchings RH, Dai H, Kachinski JL, Dolan P, Kensler TW. Antiproliferative Hybrid Analogs of the Hormone 1alpha,25-Dihydroxyvitamin D(3): Design, Synthesis, and Preliminary Biological Evaluation. The Journal of Organic Chemistry. 62: 3299-3314. PMID 11671717 DOI: 10.1021/Jo970049W |
0.541 |
|
| 1997 |
Posner GH, Ploypradith P, Hapangama W, Wang D, Cumming JN, Dolan P, Kensler TW, Klinedinst D, Shapiro TA, Zheng QY, Murray CK, Pilkington LG, Jayasinghe LR, Bray JF, Daughenbaugh R. Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro. Bioorganic & Medicinal Chemistry. 5: 1257-65. PMID 9377085 DOI: 10.1016/S0968-0896(97)00079-5 |
0.666 |
|
| 1997 |
Boyan BD, Posner GH, Greising DM, White MC, Sylvia VL, Dean DD, Schwartz Z. Hybrid structural analogues of 1,25-(OH)2D3 regulate chondrocyte proliferation and proteoglycan production as well as protein kinase C through a nongenomic pathway. Journal of Cellular Biochemistry. 66: 457-70. PMID 9282324 DOI: 10.1002/(Sici)1097-4644(19970915)66:4<457::Aid-Jcb5>3.0.Co;2-K |
0.545 |
|
| 1997 |
Greising DM, Schwartz Z, Posner GH, Sylvia VL, Dean DD, Boyan BD. A-ring analogues of 1, 25-(OH)2D3 with low affinity for the vitamin D receptor modulate chondrocytes via membrane effects that are dependent on cell maturation. Journal of Cellular Physiology. 171: 357-67. PMID 9180905 DOI: 10.1002/(Sici)1097-4652(199706)171:3<357::Aid-Jcp14>3.0.Co;2-7 |
0.32 |
|
| 1997 |
Cumming JN, Ploypradith P, Posner GH. Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action. Advances in Pharmacology (San Diego, Calif.). 37: 253-97. PMID 8891104 DOI: 10.1016/S1054-3589(08)60952-7 |
0.643 |
|
| 1997 |
Posner GH. Antimalarial endoperoxides that are potent and easily synthesized Journal of Pharmacy and Pharmacology. 49: 55-57. DOI: 10.1111/J.2042-7158.1997.Tb06161.X |
0.379 |
|
| 1997 |
Oh CH, Wang D, Cumming JN, Posner GH. Antimalarial 1,2,4-trioxanes related to artemisinin: rules for assignment of relative stereochemistry in diversely substituted analogs Spectroscopy Letters. 30: 241-255. DOI: 10.1080/00387019708006985 |
0.345 |
|
| 1997 |
Posner GH, Hutchings RH, Woodard BT. Regiocontrolled and stereocontrolled Diels-Alder cycloadditions of 2-pyrones and unactivated, unbranched 1-alkenes Synlett. 432-434. DOI: 10.1055/S-1997-6126 |
0.795 |
|
| 1997 |
Posner GH, Lee JK, White MC, Hutchings RH, Dai H, Kachinski JL, Dolan P, Kensler TW. Antiproliferative Hybrid Analogs of the Hormone 1α,25-Dihydroxyvitamin D3: Design, Synthesis, and Preliminary Biological Evaluation Journal of Organic Chemistry. 62: 3291-3298. DOI: 10.1021/jo970049w |
0.498 |
|
| 1997 |
Posner GH, González L, Cumming JN, Klinedinst D, Shapiro TA. Synthesis and antimalarial activity of heteroatom-containing bicyclic endoperoxides Tetrahedron. 53: 37-50. DOI: 10.1016/S0040-4020(96)00975-1 |
0.405 |
|
| 1996 |
Meshnick SR, Jefford CW, Posner GH, Avery MA, Peters W. Second-generation antimalarial endoperoxides. Parasitology Today (Personal Ed.). 12: 79-82. PMID 15275260 DOI: 10.1016/0169-4758(96)80660-0 |
0.341 |
|
| 1996 |
Peleg S, Liu YY, Reddy S, Horst RL, White MC, Posner GH. A 20-epi side chain restores growth-regulatory and transcriptional activities of an A ring-modified hybrid analog of 1 alpha, 25-dihydroxyvitamin D3 without increasing its affinity to the vitamin D receptor. Journal of Cellular Biochemistry. 63: 149-61. PMID 8913867 DOI: 10.1002/(Sici)1097-4644(19961101)63:2<149::Aid-Jcb3>3.0.Co;2-Y |
0.54 |
|
| 1996 |
Cumming JN, Ploypradith P, Posner GH. Antimalarial Activity of Artemisinin (Qinghaosu) and Related Trioxanes: Mechanism (s) of Action Advances in Pharmacology. 37: 253-297. DOI: 10.1016/S1054-3589(08)60952-7 |
0.566 |
|
| 1996 |
Posner GH, Tao X, Cumming JN, Klinedinst D, Shapiro TA. Antimalarially potent, easily prepared, fluorinated endoperoxides Tetrahedron Letters. 37: 7225-7228. DOI: 10.1016/0040-4039(96)01625-5 |
0.342 |
|
| 1996 |
Posner GH, Wang D, González L, Tao X, Cumming JN, Klinedinst D, Shapiro TA. Mechanism-based design of simple, symmetrical, easily prepared, potent antimalarial endoperoxides Tetrahedron Letters. 37: 815-818. DOI: 10.1016/0040-4039(95)02329-1 |
0.343 |
|
| 1995 |
Posner GH, McGarvey DJ, Oh CH, Kumar N, Meshnick SR, Asawamahasadka W. Structure-activity relationships of lactone ring-opened analogs of the antimalarial 1,2,4-trioxane artemisinin. Journal of Medicinal Chemistry. 38: 607-12. PMID 7861408 DOI: 10.1021/Jm00004A006 |
0.358 |
|
| 1995 |
Posner GH, Li Z, White MC, Vinader V, Takeuchi K, Guggino SE, Dolan P, Kensler TW. 1 alpha,25-dihydroxyvitamin D3 analogs featuring aromatic and heteroaromatic rings: design, synthesis, and preliminary biological testing. Journal of Medicinal Chemistry. 38: 4529-37. PMID 7473581 DOI: 10.1021/Jm00022A019 |
0.562 |
|
| 1995 |
Posner GH, Cho CG, Anje TEN, Johnson N, Horst RL, Kobayashi T, Okano T, Tsugawa N. 2-Fluoroalkyl a-ring analogs of 1,25-dihydroxyvitamin D3. Stereocontrolled total synthesis via intramolecular and intermolecular Diels-Alder cycloadditions. Preliminary biological testing Journal of Organic Chemistry. 60: 4617-4628. DOI: 10.1021/Jo00119A045 |
0.383 |
|
| 1995 |
Posner GH, Cumming JN, Ploypradith P, Oh CH. Evidence for Fe(IV)=O in the molecular mechanism of action of the trioxane antimalarial artemisinin Journal of the American Chemical Society. 117: 5885-5886. DOI: 10.1021/Ja00126A042 |
0.578 |
|
| 1995 |
Posner GH, Lee JK, Li Z, Takeuchi K, Guggino SE, Dolan P, Kensler TW. 1α,25-Dihydroxyvitamin D3 Hybrid Analogs with Structural changes at both the A-ring and the C,D-ring side-chain. II Bioorganic and Medicinal Chemistry Letters. 5: 2163-2168. DOI: 10.1016/S0960-894X(01)80840-4 |
0.369 |
|
| 1995 |
Posner GH, Oh CH, Gerena L, Milhous WK. Synthesis and antimalarial activities of structurally simplified 1,2,4-trioxanes related to artemisinin Heteroatom Chemistry. 6: 105-116. DOI: 10.1002/Hc.520060205 |
0.384 |
|
| 1994 |
Posner GH, Cho CG, Green JV, Zhang Y, Talalay P. Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes. Journal of Medicinal Chemistry. 37: 170-6. PMID 8289191 DOI: 10.1021/Jm00027A021 |
0.63 |
|
| 1994 |
Posner GH, Oh CH, Wang D, Gerena L, Milhous WK, Meshnick SR, Asawamahasadka W. Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity. Journal of Medicinal Chemistry. 37: 1256-8. PMID 8176702 DOI: 10.1021/Jm00035A003 |
0.321 |
|
| 1994 |
Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proceedings of the National Academy of Sciences of the United States of America. 91: 3147-50. PMID 8159717 DOI: 10.1073/Pnas.91.8.3147 |
0.62 |
|
| 1994 |
Posner GH, Johnson N. Stereocontrolled total synthesis of calcitriol derivatives: 1,25-Dihydroxy-2-(4′-hydroxybutyl)vitamin D3 analogs of an osteoporosis drug Journal of Organic Chemistry. 59: 7855-7861. DOI: 10.1021/Jo00104A050 |
0.352 |
|
| 1994 |
Posner GH, Ishihara Y. Lewis acid-catalyzed, high pressure, stereospecific, regiospecific, Diels-Alder cycloaddition of unsubstituted 2-pyrone: Short synthesis of a racemic A-ring precursor to physiologically active 1-hydroxyvitamin D3 steroids Tetrahedron Letters. 35: 7545-7548. DOI: 10.1016/S0040-4039(00)78339-0 |
0.407 |
|
| 1994 |
Posner GH, Eydoux F, Lee JK, Bull DS. Binaphthol-titanium-promoted, highly enantiocontrolled, Diels-Alder cycloadditions of electronically matched 2-pyrones and vinyl ethers: Streamlined asymmetric synthesis of an A-ring precursor to physiologically active 1α-hydroxyvitamin D3 steroids Tetrahedron Letters. 35: 7541-7544. DOI: 10.1016/S0040-4039(00)78338-9 |
0.41 |
|
| 1993 |
Posner GH, Dai H, Afarinkia K, Murthy NN, Guyton KZ, Kensler TW. Asymmetric total synthesis, X-ray crystallography, and preliminary biological evaluation of 1-(1′-hydroxyethyl)-25-hydroxyvitamin D3 analogs of natural calcitriol Journal of Organic Chemistry. 58: 7209-7215. DOI: 10.1021/Jo00077A052 |
0.357 |
|
| 1993 |
Roux MC, Seyden-Penne J, Wartski L, Posner GH, Nierlich M, Vigner D, Lance M. Scope of [1+2+3] annulations using aminonitriles as Michael donors Journal of Organic Chemistry. 58: 3969-3973. DOI: 10.1021/Jo00067A032 |
0.367 |
|
| 1993 |
Posner GH, Guyton KZ, Kensler TW, Barsony J, Lieberman ME, Reddy GS, Clark JW, Wankadiya KF, Tserng KT. 1-(hydroxyalkyl)-25-hydroxyvitamin D3 analogs of calcitriol. 2. Preliminary biological evaluation Bioorganic and Medicinal Chemistry Letters. 3: 1835-1840. DOI: 10.1016/S0960-894X(00)80115-8 |
0.31 |
|
| 1993 |
Posner GH, Dai H. 1-(hydroxyalkyl)-25-hydroxyvitamin D3 analogs of calcitriol. 1. Synthesis Bioorganic and Medicinal Chemistry Letters. 3: 1829-1834. DOI: 10.1016/S0960-894X(00)80114-6 |
0.387 |
|
| 1992 |
Posner GH, Oh CH, Gerena L, Milhous WK. Extraordinarily potent antimalarial compounds: new, structurally simple, easily synthesized, tricyclic 1,2,4-trioxanes. Journal of Medicinal Chemistry. 35: 2459-67. PMID 1619620 DOI: 10.1021/Jm00091A014 |
0.382 |
|
| 1992 |
Zhang Y, Talalay P, Cho CG, Posner GH. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proceedings of the National Academy of Sciences of the United States of America. 89: 2399-403. PMID 1549603 DOI: 10.1073/Pnas.89.6.2399 |
0.607 |
|
| 1992 |
Zhang Y, Cho CG, Posner GH, Talalay P. Spectroscopic quantitation of organic isothiocyanates by cyclocondensation with vicinal dithiols. Analytical Biochemistry. 205: 100-7. PMID 1443546 DOI: 10.1016/0003-2697(92)90585-U |
0.622 |
|
| 1992 |
Posner GH, Nelson TD, Guyton KZ, Kensler TW. New vitamin D3 derivatives with unexpected antiproliferative activity: 1-(hydroxymethyl)-25-hydroxyvitamin D3 homologs. Journal of Medicinal Chemistry. 35: 3280-7. PMID 1324319 DOI: 10.1021/Jm00095A026 |
0.372 |
|
| 1992 |
Posner GH, Carry JC, Anjeh TEN, French AN. A new and efficient asymmetric synthesis of an A-ring precursor to physiologically active 1.alpha.-hydroxyvitamin D3 steroids The Journal of Organic Chemistry. 57: 7012-7014. DOI: 10.1021/Jo00052A007 |
0.43 |
|
| 1992 |
Posner GH, Vinader V, Afarinkia K. Diels-Alder cycloadditions using nucleophilic 2-pyridones. Regiocontrolled and stereocontrolled synthesis of unsaturated, bridged, bicyclic lactams The Journal of Organic Chemistry. 57: 4088-4097. DOI: 10.1021/Jo00041A010 |
0.379 |
|
| 1992 |
Posner GH, Nelson TD, Kinter CM, Johnson N. Diels-Alder cycloadditions using nucleophilic 3-(p-tolylthio)-2-pyrone. Regiocontrolled and stereocontrolled synthesis of unsaturated, bridged, bicyclic lactones The Journal of Organic Chemistry. 57: 4083-4088. DOI: 10.1021/Jo00041A009 |
0.373 |
|
| 1992 |
Cho C, Posner GH. Alkyl and aryl isothiocyanates as masked primary amines Tetrahedron Letters. 33: 3599-3602. DOI: 10.1016/S0040-4039(00)92512-7 |
0.336 |
|
| 1992 |
Afarinkia K, Posner GH. 5-Bromo-2-pyrone: An easily prepared ambiphilic diene and a synthetic equivalent of 2-pyrone in mild, thermal, Diels-Alder cycloadditions Tetrahedron Letters. 33: 7839-7842. DOI: 10.1016/S0040-4039(00)74757-5 |
0.358 |
|
| 1992 |
Afarinkia K, Vinader V, Nelson TD, Posner GH. Diels-Alder cycloadditions of 2-pyrones and 2-pyridones Tetrahedron. 48: 9111-9171. DOI: 10.1016/S0040-4020(01)85607-6 |
0.337 |
|
| 1992 |
Posner GH, Shulman-Roskes EM. A one-flask multicomponent annulation reaction as the key step in a total synthesis of spirobicyclic (±)-β-vetivone Tetrahedron. 48: 4677-4686. DOI: 10.1016/S0040-4020(01)81566-0 |
0.329 |
|
| 1991 |
Posner GH, Crouch RD, Kinter CM, Carry JC. One-flask, regiospecific conversions of allylic alcohols into 2-carbon-extended, conjugated dienoate esters. Use of a new sulfinyl orthoester The Journal of Organic Chemistry. 56: 6981-6987. DOI: 10.1021/Jo00025A008 |
0.308 |
|
| 1991 |
Posner GH, Nelson TD. Stereocontrolled synthesis of a trihydroxylated A ring as an immediate precursor to 1.alpha.,2.alpha.,25-trihydroxyvitamin D3 The Journal of Organic Chemistry. 56: 4339-4341. DOI: 10.1021/Jo00014A003 |
0.38 |
|
| 1991 |
Posner GH, Nelson TD, Kinter CM, Afarinkia K. 3-bromo-2-pyrone: an easily prepared chameleon diene and a synthetic equivalent of 2-pyrone in thermal diels-alder cycloadditions Tetrahedron Letters. 32: 5295-5298. DOI: 10.1016/S0040-4039(00)92368-2 |
0.329 |
|
| 1991 |
Posner GH, Ho Oh C, Milhous WK. Olefin oxidative cleavage and dioxetane formation using triethylsilyl hydrotrioxide: Applications to preparation of potent antimalarial 1,2,4-trioxanes Tetrahedron Letters. 32: 4235-4238. DOI: 10.1016/S0040-4039(00)92136-1 |
0.313 |
|
| 1990 |
Posner GH. New synthetic methodology using organosulfur compounds Pure and Applied Chemistry. 62: 1949-1956. DOI: 10.1351/Pac199062101949 |
0.367 |
|
| 1990 |
Posner GH, Kinter CM. Asymmetric total synthesis of an A-ring precursor to hormonally active 1.alpha.,25-dihydroxyvitamin D3 The Journal of Organic Chemistry. 55: 3967-3969. DOI: 10.1021/Jo00300A001 |
0.364 |
|
| 1990 |
Posner GH, Asirvatham E, Hamill TG, Webb KS. Three-different-component [1+2+n]-annulation reactions: ionic and radical cyclizations The Journal of Organic Chemistry. 55: 2132-2137. DOI: 10.1021/Jo00294A029 |
0.304 |
|
| 1990 |
Posner GH, David Crouch R. Nitroolefins in one-flask, tandem. A+B+C coupling reactions producing heterocycles Tetrahedron. 46: 7509-7530. DOI: 10.1016/S0040-4020(01)89064-5 |
0.332 |
|
| 1990 |
Posner GH, Nelson TD. Stereocontrolled synthesis of highly functionalized cyclohexenes. A short synthesis of a chorismic acid precursor Tetrahedron. 46: 4573-4586. DOI: 10.1016/S0040-4020(01)85582-4 |
0.345 |
|
| 1989 |
Posner GH, Shulman-Roskes EM. Interrupted polymerization of acrylates: sequential Michael-Michael-Dieckmann cyclizations for easy, one-pot, 2 + 2 + 2 construction of polyfunctionalized cyclohexanones The Journal of Organic Chemistry. 54: 3514-3515. DOI: 10.1021/Jo00276A002 |
0.313 |
|
| 1989 |
Corey EJ, Posner GH, Atkinson RF, Wingard AK, Halloran DJ, Radzik DM, Nash JJ. Formation of olefins via pyrolysis of sulfonate esters The Journal of Organic Chemistry. 54: 389-393. DOI: 10.1021/Jo00263A024 |
0.466 |
|
| 1988 |
Posner GH, Webb KS, Asirvatham E, Jew SS, Degl'Innocenti A. One-pot, four-component annulations: flexible and simple syntheses of unsaturated macrolides and of substituted aromatics and heteroaromatics Journal of the American Chemical Society. 110: 4754-4762. DOI: 10.1021/Ja00222A038 |
0.352 |
|
| 1987 |
Posner GH, Weitzberg M, Jew S. Asymmetric Conjugate Additions of an Hydroxymethyl Carbanion Equivalent. Synthesis of (+)-A Factor Synthetic Communications. 17: 611-620. DOI: 10.1080/00397918708075735 |
0.331 |
|
| 1987 |
Posner GH, Switzer C. Diels-Alder cycloadditions using electrophilic sulfonyl pyridones The Journal of Organic Chemistry. 52: 1642-1644. DOI: 10.1021/Jo00384A061 |
0.646 |
|
| 1987 |
Posner GH, Weitzberg M, Nelson WM, Murr BL, Seliger HH. 1,2-Dioxetanes from vinyl aromatics Journal of the American Chemical Society. 109: 278-279. DOI: 10.1021/Ja00235A045 |
0.332 |
|
| 1987 |
Posner GH, Asirvatham E, Webb KS, Jew S. One-pot, four-different-component annulations: flexible and efficient conversion of n-sized cycloalkenones into n+4 alkenolides Tetrahedron Letters. 28: 5071-5074. DOI: 10.1016/S0040-4039(00)95592-8 |
0.315 |
|
| 1986 |
Posner GH, Lu SB, Asirvatham E, Silversmith EF, Shulman EM. Sequential Michael-Michael-aldol additions for easy, one-pot, 2 + 2 + 2 construction of polyfunctionalized cyclohexanols. Journal of the American Chemical Society. 108: 511-2. PMID 22175474 DOI: 10.1002/Chin.198623109 |
0.316 |
|
| 1986 |
Posner GH, Wettlaufer DG. Highly stereocontrolled synthesis of some trioxygenated cyclohexenes: an asymmetric total synthesis of (-)-methyl triacetyl-4-epishikimate Journal of the American Chemical Society. 108: 7373-7377. DOI: 10.1021/Ja00283A036 |
0.351 |
|
| 1986 |
Posner GH, Switzer C. Total synthesis of natural estrone and estradiol methyl ethers in extremely high enantiomeric purity via an asymmetric Michael addition to an unsaturated sulfoxide Journal of the American Chemical Society. 108: 1239-1244. DOI: 10.1021/Ja00266A019 |
0.681 |
|
| 1986 |
Posner GH, Wettlaufer DG. Asymmetric Diels-Alder cycloadditions using chiral alkyl vinyl ethers and a dienyl sulfone Tetrahedron Letters. 27: 667-670. DOI: 10.1016/S0040-4039(00)84068-X |
0.349 |
|
| 1986 |
Posner GH, Asirvatham E. Sequential Michael-Michael-Michael-Ring Closure reactions for high-yield, one-pot, 4-component coupling Tetrahedron Letters. 27: 663-666. DOI: 10.1016/S0040-4039(00)84067-8 |
0.312 |
|
| 1986 |
Posner GH, Lu S, Asirvatham E. Sequential Michael-Michael-Ring Closure reactions for 3-different-component, one-pot, 2+2+2 construction of acylcyclohexenes and an acylcyclohexanol Tetrahedron Letters. 27: 659-662. DOI: 10.1016/S0040-4039(00)84066-6 |
0.352 |
|
| 1986 |
Posner GH, Weitzberg M, Hamill TG, Asirvatham E, Cun-heng H, Clardy J. Asymmetric michael additions of ester enolates to enantiomerically pure vinylic sulfoxides Tetrahedron. 42: 2919-2929. DOI: 10.1016/S0040-4020(01)90581-2 |
0.344 |
|
| 1986 |
Kahana N, Barness I, Posner GH. Catalytic and enantioselective ester hydrolysis by a modified polyethylenimine Journal of Polymer Science Part C: Polymer Letters. 24: 41-47. DOI: 10.1002/Pol.1986.140240108 |
0.318 |
|
| 1986 |
POSNER GH, HARRISON W. ChemInform Abstract: Diels-Alder Cycloadditions Using Alkenyl Sulphoxides. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198617112 |
0.334 |
|
| 1985 |
Posner GH, Harrison W. Diels–Alder cycloadditions using alkenyl sulphoxides Journal of the Chemical Society, Chemical Communications. 1786-1787. DOI: 10.1039/C39850001786 |
0.327 |
|
| 1985 |
Posner GH, Asirvatham E, Ali SF. Additive Pummerer rearrangements. Asymmetric synthesis of (–)-methyl jasmonate Journal of the Chemical Society, Chemical Communications. 542-543. DOI: 10.1039/C39850000542 |
0.359 |
|
| 1985 |
Posner GH, Haines SR. Conversion of glycosyl fluorides into -glycosides using organoaluminum reagents. Stereospecific alkylation at C-6 of a pyranose sugar Tetrahedron Letters. 26: 1823-1826. DOI: 10.1016/S0040-4039(00)94747-6 |
0.347 |
|
| 1985 |
Posner GH, Frye LL. α-Fluorination of β-keto sulfoxides Journal of Fluorine Chemistry. 28: 151-159. DOI: 10.1016/S0022-1139(00)81138-0 |
0.304 |
|
| 1985 |
Posner GH, Barness I, Biggley WH, Seliger HH, Kaplan DC. Preparation of ring-tritiated and of aldehyde-14C-labelled 1-pyrenecarboxaldehyde Journal of Labelled Compounds and Radiopharmaceuticals. 22: 1023-1031. DOI: 10.1002/Jlcr.2580221005 |
0.391 |
|
| 1985 |
Posner GH, Harrison W, Wettlaufer DG. 3-Cuprio-2-pyrone: an extraordinary organocopper reagent The Journal of Organic Chemistry. 50: 5041-5044. DOI: 10.1002/Chin.198619183 |
0.315 |
|
| 1985 |
Posner GH, Asirvatham E. A short, asymmetric synthesis of natural (-)-methyl jasmonate The Journal of Organic Chemistry. 50: 2589-2591. DOI: 10.1002/Chin.198602333 |
0.329 |
|
| 1985 |
POSNER GH, ASIRVATHAM E, ALI SF. ChemInform Abstract: ADDITIVE PUMMERER REARRANGEMENTS. ASYMMETRIC SYNTHESIS OF (-)-METHYL JASMONATE Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198533168 |
0.345 |
|
| 1984 |
Posner GH, Kogan TP, Haines SR, Frye LL. )-(+)-2-(-tolylsulfinyl)-2-buten-4-olide: an enantiomerically pure Michael acceptor for asymmetric synthesis of 3-substituted 4-butanolides. (—)-podorhizon. Tetrahedron Letters. 25: 2627-2630. DOI: 10.1016/S0040-4039(01)81247-8 |
0.387 |
|
| 1984 |
Posner GH, Kogan TP, Hulce M. Enantiocontrolled synthesis of quaternary carbon centers. 3,3-Disubstituted cyclopentanones. (+)-α-cuparenone. Tetrahedron Letters. 25: 383-386. DOI: 10.1016/S0040-4039(00)99889-7 |
0.76 |
|
| 1984 |
Posner GH, Hulce M. Enantiocontrolled synthesis of ()-3-substituted cycloalkanones from ()-2-(-tolylsulfinyl)-2-cycloalkenones and diorganomagnesium reagents. Tetrahedron Letters. 25: 379-382. DOI: 10.1016/S0040-4039(00)99888-5 |
0.761 |
|
| 1984 |
Posner GH, Frye LL, Hulce M. Asymmetric synthesis using enantiomerically pure 2-(p-anisylsulfinyl)-2-cycloalkenones Tetrahedron. 40: 1401-1407. DOI: 10.1016/S0040-4020(01)82425-X |
0.751 |
|
| 1984 |
Posner GH, Frye LL. Enantiocontrolled Synthesis of (R)-3-Substituted Cyclohexanones Using (S)-2-(p-Tolylsulfinyl)-2-cyclohexenone and Various Organometallic Reagents in 2,5-Dimethyltetrahydrofuran Israel Journal of Chemistry. 24: 88-92. DOI: 10.1002/Chin.198450142 |
0.301 |
|
| 1982 |
Posner GH, Mallamo JP, Hulce M, Frye LL. Asymmetric induction during organometallic conjugate addition to enantiomerically pure 2-(arylsulfinyl)-2-cyclopentenones Journal of the American Chemical Society. 104: 4180-4185. DOI: 10.1021/Ja00379A022 |
0.759 |
|
| 1982 |
POSNER GH, MALLAMO JP, MIURA K, HULCE M. ChemInform Abstract: ASYMMETRIC SYNTHESIS USING ORGANOMETALLIC REAGENTS AND OPTICALLY PURE VINYLIC SULFOXIDES Chemischer Informationsdienst. 13. DOI: 10.1002/Chin.198216103 |
0.749 |
|
| 1981 |
Posner GH, Mallamo JP, Miura K, Hulce M. Asymmetric synthesis using organometallic reagents and optically pure vinylic sulfoxides Pure and Applied Chemistry. 53: 2307-2314. DOI: 10.1351/Pac198153122307 |
0.751 |
|
| 1981 |
Posner GH, Hulce M, Rose RK. Alumina-promoted Opening of Medium Ring Epoxides:cis-Cyclooctene Oxide -trans-2-Acetoxycyclooctanol Synthetic Communications. 11: 737-741. DOI: 10.1080/00397918108063651 |
0.758 |
|
| 1981 |
Posner GH, Mallamo JP, Black AY. Tandem michael-michael-ring closure (mimirc) reactions Tetrahedron. 37: 3921-3926. DOI: 10.1016/S0040-4020(01)93265-X |
0.347 |
|
| 1981 |
Posner GH, Hulce M, Mallamo JP, Drexler SA, Clardy J. Complete asymmetric induction in synthesis of enantiomerically pure steroid intermediates of natural configuration The Journal of Organic Chemistry. 46: 5244-5246. DOI: 10.1002/Chin.198220099 |
0.773 |
|
| 1981 |
Posner GH, Mallamo JP, Miura K. HIGH ASYMMETRIC INDUCTION DURING ORGANOMETALLIC β‐ADDITION TO α,β‐ETHYLENIC SULFOXIDES. SYNTHESIS OF OPTICALLY ACTIVE β‐ALKYLCARBOXYLIC ACIDS, β‐SUBSTITUTED CYCLOPENTANONES, AND STEROIDAL 11‐OXOEQUILENIN METHYL ETHER Cheminform. 12. DOI: 10.1002/Chin.198136094 |
0.344 |
|
| 1980 |
POSNER GH, CHAPDELAINE MJ, LENTZ CM. ChemInform Abstract: SHORT, SIMPLE, STEREOCONTROLLED, STEROID SYNTHESIS: (.+-.)-11-OXOEQUILENIN METHYL ETHER AND A NEW 9,11-SECO-13-ETHYL STEROID Chemischer Informationsdienst. 11. DOI: 10.1002/Chin.198007335 |
0.361 |
|
| 1979 |
Posner GH, Chapdelaine MJ, Lentz CM. Short, simple, stereocontrolled, steroid synthesis: (.+-.)-11-oxoequilenin methyl ether and a new 9,11-seco-13-ethyl steroid The Journal of Organic Chemistry. 44: 3661-3665. DOI: 10.1021/Jo01335A009 |
0.355 |
|
| 1979 |
Posner GH, Lentz CM. A directing effect of neighboring aromatic groups on the regiochemistry of formation and stereochemistry of alkylation and bromination of ketone lithium enolates. Evidence for lithium-arene coordination and dramatic effect of copper(I) in controlling stereochemistry and limiting polyalkylation Journal of the American Chemical Society. 101: 934-946. DOI: 10.1021/Ja00498A023 |
0.32 |
|
| 1979 |
Posner GH, Babiak KA. Some unusual aspect aspects of organocopper chemistry: lithium organocuprate reaction with some neopentylic p-tosylate esters Journal of Organometallic Chemistry. 177: 299-307. DOI: 10.1016/S0022-328X(00)92356-8 |
0.325 |
|
| 1979 |
ALEXAKIS A, CHAPDELAINE MJ, POSNER GH, RUNQUIST AW. ChemInform Abstract: A NEW SYNTHETIC APPROACH TO PSEUDOGUAIANES Chemischer Informationsdienst. 10. DOI: 10.1002/chin.197909318 |
0.402 |
|
| 1979 |
ALEXAKIS A, CHAPDELAINE MJ, POSNER GH. ChemInform Abstract: A NEW APPROACH TO THE BICYCLO(3.2.1)OCTANE RING SYSTEM: INTRAMOLECULAR MICHAEL AND ALDOL REACTIONS OF 3-(5-OXOHEXYL)-2-CYCLOPENTENONES Chemischer Informationsdienst. 10. DOI: 10.1002/chin.197909147 |
0.465 |
|
| 1978 |
Posner GH, Tang P. Stereocontrolled preparation of chiral (E)-1-alkenyl sulfoxides. Efficient reduction of alkenyl sulfoxides to the corresponding alkenyl sulfides The Journal of Organic Chemistry. 43: 4131-4136. DOI: 10.1021/Jo00415A032 |
0.303 |
|
| 1978 |
Posner GH, Loomis GL, Hittal RD, Frazee W, Schmit DH, Babiak KA. Synthesis and characterization of two stereoisomeric hydroazulenones. Versatile precursors to guaianolides. Tetrahedron Letters. 19: 4213-4216. DOI: 10.1016/S0040-4039(01)95184-6 |
0.353 |
|
| 1978 |
Alexakis A, Chapdelaine MJ, Posner GH. A new approach to the bicyclo[3.2.1]octane ring system: Intramolecular michael and aldol reactions of 3-(5-oxohexyl)-2-cyclopentenones. Tetrahedron Letters. 19: 4209-4212. DOI: 10.1016/S0040-4039(01)95183-4 |
0.521 |
|
| 1978 |
Alexakis A, Chapdelaine M, Posner G, Runquist A. A new synthetic approach to pseudoguaianes. Tetrahedron Letters. 19: 4205-4208. DOI: 10.1016/S0040-4039(01)95182-2 |
0.458 |
|
| 1977 |
Posner GH, Whitten CE, Sterling JJ, Brunelle DJ, Lentz CM, Runquist AW, Alexakis A. NEW ORGANOCOPPER SYNTHETIC METHODS. ?,?-DIALKYLATION OF ?,?-ETHYLENIC KETONES: SYNTHESIS OF SESQUITERPENES Annals of the New York Academy of Sciences. 295: 249-253. DOI: 10.1111/J.1749-6632.1977.Tb41839.X |
0.531 |
|
| 1977 |
Posner GH, Lentz CM. A surprising effect of a 3-phenyl group on the stereochemistry of cyclopentanone enolate alkylation. Highly stereoselective organocopper 2,3-dialkylation of 2-cyclopentenones. Synthesis of sesquiterpene hydrocarbon (±)-laurene Tetrahedron Letters. 18: 3215-3218. DOI: 10.1016/S0040-4039(01)83200-7 |
0.319 |
|
| 1977 |
Posner GH, Lentz CM. A surprising effect of 3-aryl groups on the regiochemistry of formation of cyclopentanone lithium enolates. Evidence for lithium-arene π-coordination Tetrahedron Letters. 18: 3211-3214. DOI: 10.1016/S0040-4039(01)83199-3 |
0.305 |
|
| 1976 |
Posner GH, Ting JS, Lentz CM. A mechanistic and synthetic study of organocopper substitution reactions with some homoallylic and cyclopropylcarbinyl substrates. Application to isoprenoid synthesis Tetrahedron. 32: 2281-2287. DOI: 10.1016/0040-4020(76)88002-7 |
0.368 |
|
| 1975 |
Posner GH, Sterling JJ, Whitten CE, Lentz CM, Brunelle DJ. Alkylation of enolate ions generated regiospecifically via organocopper reactions. Synthesis of decalin sesquiterpene valerane and of prostaglandin model systems. Journal of the American Chemical Society. 97: 107-18. PMID 1133327 DOI: 10.1021/Ja00834A019 |
0.65 |
|
| 1975 |
Posner GH, Loomis GL, Sawaya HS. An efficient method for dibromomethylenation and isopropylidenation of ketones (). Synthesis of a selinadiene sesquiterpene. Tetrahedron Letters. 16: 1373-1376. DOI: 10.1016/S0040-4039(00)72146-0 |
0.308 |
|
| 1975 |
Posner GH, Ting JS. Dechloroethylation Of Chloroethyl Ethers And Amines Using n-Butyllithium Synthetic Communications. 5: 331-339. DOI: 10.1002/Chin.197551150 |
0.326 |
|
| 1974 |
Posner GH, Whitten CE, Sterling JJ, Brunelle DJ. Alkylation of enolate ions generated regiospecifically via organocopper conjugate addition reactions. Synthesis of decalin sesquiterpene valerane and of a prostaglandin model system Tetrahedron Letters. 15: 2591-2594. DOI: 10.1016/S0040-4039(01)92301-9 |
0.662 |
|
| 1974 |
Posner GH, Ting JS. A new direct method for selective demethylation of n+-methyl quaternary ammonium iodides Synthetic Communications. 4: 355-366. DOI: 10.1002/Chin.197513174 |
0.307 |
|
| 1973 |
Posner GH, Ting JS. Reductive Elimination of Bromine From 1,2-Dibromoalkanes Using Organometallic Reagents Synthetic Communications. 3: 281-285. DOI: 10.1080/00397917308065917 |
0.349 |
|
| 1973 |
Posner GH, Brunelle DJ. Reaction of lithium dialkylcuprates with β-alkoxy and β-alkylthio αβ-unsaturated carbonyl compounds Journal of the Chemical Society, Chemical Communications. 907-908. DOI: 10.1039/C39730000907 |
0.645 |
|
| 1973 |
Gurria GM, Posner GH. Photochemical deoxygenation of aryl sulfoxides Journal of Organic Chemistry. 38: 2419-2420. DOI: 10.1021/Jo00953A034 |
0.356 |
|
| 1973 |
Posner GH, Whitten CE, Sterling JJ. New class of mixed cuprate(I) reagents, lithium hetero(alkyl) cuprate(I), which allow selective alkyl group transfer Journal of the American Chemical Society. 95: 7788-7800. DOI: 10.1021/Ja00804A041 |
0.305 |
|
| 1973 |
Posner GH, Whitten CE. Substitution and conjugate addition reactions using new lithium -butoxy-alkylcuprate(I) reagents Tetrahedron Letters. 14: 1815-1818. DOI: 10.1016/S0040-4039(01)96247-1 |
0.343 |
|
| 1973 |
Posner GH, Brunelle DJ. Organocopper chemistry. Reaction of α,β-ethylenic sulfones with lithium dialkylcuprates Tetrahedron Letters. 14: 935-938. DOI: 10.1016/S0040-4039(00)72455-5 |
0.644 |
|
| 1972 |
Posner GH, Loomis GL. A useful method for α-methylation of γ-butyrolactones Journal of the Chemical Society, Chemical Communications. 892-893. DOI: 10.1039/C39720000892 |
0.307 |
|
| 1972 |
Posner GH, Whitten CE, McFarland P. Organocopper chemistry. Halo-, cyano-, and carbonyl-substituted ketones from the corresponding acyl chlorides and organocopper reagents Journal of the American Chemical Society. 94: 5106-5108. DOI: 10.1021/Ja00769A066 |
0.391 |
|
| 1972 |
Posner GH, Brunelle DJ. Organocopper chemistry. reaction of benzal and other benzylic chlorides with lithium dimethylcopper Tetrahedron Letters. 13: 293-296. DOI: 10.1016/S0040-4039(01)84304-5 |
0.645 |
|
| 1970 |
Posner G, Whitten C. Methyl and -alkyl ketones from carboxylic acid chlorides and organocopper reagents Tetrahedron Letters. 11: 4647-4650. DOI: 10.1016/S0040-4039(00)89398-3 |
0.308 |
|
| 1970 |
Corey E, Posner G. A study of cross coupling reactions between halides and anionic manganese, iron, and cobalt alkyls Tetrahedron Letters. 11: 315-318. DOI: 10.1016/S0040-4039(00)61817-8 |
0.31 |
|
| 1970 |
COREY EJ, POSNER GH. ChemInform Abstract: GEKREUZTE KUPPLUNGSRK. ZWISCHEN HALOGENIDEN UND ANIONISCHEN MANGAN-, EISEN- UND KOBALT-ALKYL-VERBINDUNGEN Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/chin.197019379 |
0.365 |
|
| 1968 |
Corey EJ, Posner GH. Carbon-carbon bond formation by selective coupling of n-alkylcopper reagents with organic halides Journal of the American Chemical Society. 90: 5615-5616. DOI: 10.1021/Ja01022A058 |
0.393 |
|
| 1967 |
Corey EJ, Katzenellenbogen JA, Posner GH. New stereospecific synthesis of trisubstituted olefins. Stereospecific synthesis of farnesol Journal of the American Chemical Society. 89: 4245-4247. DOI: 10.1021/Ja00992A065 |
0.591 |
|
| 1967 |
Corey EJ, Posner GH. Selective formation of carbon-carbon bonds between unlike groups using organocopper reagents Journal of the American Chemical Society. 89: 3911-3912. DOI: 10.1021/Ja00991A049 |
0.387 |
|
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