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David W.C. MacMillan - Publications

Affiliations: 
2000-2006 California Institute of Technology, Pasadena, CA 
 2006- Princeton University, Princeton, NJ 
Area:
Organic Synthesis, enantioselective catalysis
Website:
https://macmillan.princeton.edu/
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81 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 González-Esguevillas M, Miró J, Jeffrey JL, MacMillan DW. Photoredox-catalyzed deoxyfluorination of activated alcohols with Selectfluor® Tetrahedron. 75: 4222-4227. DOI: 10.1016/j.tet.2019.05.043  0.729
2018 Twilton J, Christensen M, DiRocco DA, Ruck RT, Davies IW, MacMillan DW. Selective Hydrogen Atom Abstraction via Induced Bond Polarization: The Direct -Arylation of Alcohols via Photoredox, HAT and Nickel Catalysis. Angewandte Chemie (International Ed. in English). PMID 29490112 DOI: 10.1002/Anie.201800749  0.793
2018 Kim T, McCarver S, Lee C, MacMillan DW. Sulfonamidation of Aryl and Heteroaryl Halides via Photosensitized Nickel Catalysis. Angewandte Chemie (International Ed. in English). PMID 29424956 DOI: 10.1002/Anie.201800699  0.371
2017 Welin ER, Le C, Arias-Rotondo DM, McCusker JK, MacMillan DW. Photosensitized, energy transfer-mediated organometallic catalysis through electronically excited nickel(II). Science (New York, N.Y.). 355: 380-385. PMID 28126814 DOI: 10.1126/Science.Aal2490  0.784
2016 McCarver SJ, Qiao JX, Carpenter J, Borzilleri RM, Poss MA, Eastgate MD, Miller M, MacMillan DW. Decarboxylative Peptide Macrocyclization through Photoredox Catalysis. Angewandte Chemie (International Ed. in English). PMID 27860140 DOI: 10.1002/Anie.201608207  0.523
2016 Zhang X, MacMillan DW. Alcohols as Latent Coupling Fragments for Metallaphotoredox Catalysis: sp3-sp2 Cross-Coupling of Oxalates with Aryl Halides. Journal of the American Chemical Society. PMID 27718570 DOI: 10.1021/Jacs.6B09533  0.743
2016 Johnston CP, Smith RT, Allmendinger S, MacMillan DW. Metallaphotoredox-catalysed sp(3)-sp(3) cross-coupling of carboxylic acids with alkyl halides. Nature. 536: 322-5. PMID 27535536 DOI: 10.1038/Nature19056  0.442
2016 Shaw MH, Twilton J, MacMillan DW. Photoredox Catalysis in Organic Chemistry. The Journal of Organic Chemistry. PMID 27477076 DOI: 10.1021/Acs.Joc.6B01449  0.791
2016 Corcoran EB, Pirnot MT, Lin S, Dreher SD, DiRocco DA, Davies IW, Buchwald SL, MacMillan DW. Aryl amination using ligand-free Ni(II) salts and photoredox catalysis. Science (New York, N.Y.). 353: 279-83. PMID 27338703 DOI: 10.1126/Science.Aag0209  0.801
2016 Zhang P, Le CC, MacMillan DW. Silyl Radical Activation of Alkyl Halides in Metallaphotoredox Catalysis: A Unique Pathway for Cross-Electrophile Coupling. Journal of the American Chemical Society. PMID 27263662 DOI: 10.1021/Jacs.6B04818  0.442
2016 Shaw MH, Shurtleff VW, Terrett JA, Cuthbertson JD, MacMillan DW. Native functionality in triple catalytic cross-coupling: sp3 C-H bonds as latent nucleophiles. Science (New York, N.Y.). PMID 27127237 DOI: 10.1126/Science.Aaf6635  0.764
2016 Zuo Z, Cong H, Li W, Choi J, Fu GC, MacMillan DW. Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis. Journal of the American Chemical Society. PMID 26849354 DOI: 10.1021/Jacs.5B13211  0.73
2016 Nawrat CC, Jamison CR, Slutskyy Y, MacMillan DW, Overman LE. Correction to "Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling". Journal of the American Chemical Society. PMID 26820773 DOI: 10.1021/jacs.6b00456  0.784
2016 Liu C, Oblak EZ, Vander Wal MN, Dilger AK, Almstead DK, MacMillan DW. Oxy-Allyl Cation Catalysis: An Enantioselective Electrophilic Activation Mode. Journal of the American Chemical Society. PMID 26797012 DOI: 10.1021/Jacs.5B13041  0.825
2015 Le CC, MacMillan DW. Fragment Couplings via CO2 Extrusion-Recombination: Expansion of a Classic Bond-Forming Strategy via Metallaphotoredox. Journal of the American Chemical Society. 137: 11938-41. PMID 26333771 DOI: 10.1021/Jacs.5B08304  0.664
2015 Nawrat CC, Jamison CR, Slutskyy Y, MacMillan DW, Overman LE. Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling. Journal of the American Chemical Society. 137: 11270-3. PMID 26322524 DOI: 10.1021/Jacs.5B07678  0.79
2015 Jeffrey JL, Terrett JA, MacMillan DW. O-H hydrogen bonding promotes H-atom transfer from α C-H bonds for C-alkylation of alcohols. Science (New York, N.Y.). 349: 1532-6. PMID 26316601 DOI: 10.1126/Science.Aac8555  0.759
2015 Jin J, MacMillan DW. Alcohols as alkylating agents in heteroarene C-H functionalization. Nature. 525: 87-90. PMID 26308895 DOI: 10.1038/Nature14885  0.429
2015 Terrett JA, Cuthbertson JD, Shurtleff VW, MacMillan DW. Switching on elusive organometallic mechanisms with photoredox catalysis. Nature. 524: 330-4. PMID 26266976 DOI: 10.1038/Nature14875  0.787
2015 Welin ER, Warkentin AA, Conrad JC, MacMillan DW. Enantioselective α-Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from β-Cyanoaldehydes. Angewandte Chemie (International Ed. in English). 54: 9668-72. PMID 26130043 DOI: 10.1002/Anie.201503789  0.824
2015 Jeffrey JL, Petronijevi? FR, MacMillan DW. Selective Radical-Radical Cross-Couplings: Design of a Formal β-Mannich Reaction. Journal of the American Chemical Society. 137: 8404-7. PMID 26075347 DOI: 10.1021/Jacs.5B05376  0.794
2015 Chu L, Lipshultz JM, MacMillan DW. Merging Photoredox and Nickel Catalysis: The Direct Synthesis of Ketones by the Decarboxylative Arylation of α-Oxo Acids. Angewandte Chemie (International Ed. in English). 54: 7929-33. PMID 26014029 DOI: 10.1002/Anie.201501908  0.506
2015 Ventre S, Petronijevic FR, MacMillan DW. Decarboxylative Fluorination of Aliphatic Carboxylic Acids via Photoredox Catalysis. Journal of the American Chemical Society. 137: 5654-7. PMID 25881929 DOI: 10.1021/Jacs.5B02244  0.402
2015 Noble A, McCarver SJ, MacMillan DW. Merging photoredox and nickel catalysis: decarboxylative cross-coupling of carboxylic acids with vinyl halides. Journal of the American Chemical Society. 137: 624-7. PMID 25521443 DOI: 10.1021/Ja511913H  0.64
2015 Jin J, MacMillan DW. Direct α-arylation of ethers through the combination of photoredox-mediated C-H functionalization and the Minisci reaction. Angewandte Chemie (International Ed. in English). 54: 1565-9. PMID 25470570 DOI: 10.1002/Anie.201410432  0.49
2014 Prier CK, MacMillan DW. Amine α-heteroarylation via photoredox catalysis: a homolytic aromatic substitution pathway. Chemical Science (Royal Society of Chemistry : 2010). 5: 4173-4178. PMID 26236461 DOI: 10.1039/C4Sc02155J  0.817
2014 Hager D, MacMillan DW. Activation of C-H bonds via the merger of photoredox and organocatalysis: a coupling of benzylic ethers with Schiff bases. Journal of the American Chemical Society. 136: 16986-9. PMID 25457231 DOI: 10.1021/Ja5102695  0.47
2014 Chu L, Ohta C, Zuo Z, MacMillan DW. Carboxylic acids as a traceless activation group for conjugate additions: a three-step synthesis of (±)-pregabalin. Journal of the American Chemical Society. 136: 10886-9. PMID 25032785 DOI: 10.1021/Ja505964R  0.615
2014 Noble A, MacMillan DW. Photoredox α-vinylation of α-amino acids and N-aryl amines. Journal of the American Chemical Society. 136: 11602-5. PMID 25026314 DOI: 10.1021/Ja506094D  0.657
2014 Zuo Z, Ahneman DT, Chu L, Terrett JA, Doyle AG, MacMillan DW. Dual catalysis. Merging photoredox with nickel catalysis: coupling of α-carboxyl sp³-carbons with aryl halides. Science (New York, N.Y.). 345: 437-40. PMID 24903563 DOI: 10.1126/Science.1255525  0.603
2014 Terrett JA, Clift MD, MacMillan DW. Direct β-alkylation of aldehydes via photoredox organocatalysis. Journal of the American Chemical Society. 136: 6858-61. PMID 24754456 DOI: 10.1021/Ja502639E  0.749
2014 Zuo Z, MacMillan DW. Decarboxylative arylation of α-amino acids via photoredox catalysis: a one-step conversion of biomass to drug pharmacophore. Journal of the American Chemical Society. 136: 5257-60. PMID 24712922 DOI: 10.1021/Ja501621Q  0.575
2014 Peifer M, Berger R, Shurtleff VW, Conrad JC, MacMillan DW. A general and enantioselective approach to pentoses: a rapid synthesis of PSI-6130, the nucleoside core of sofosbuvir. Journal of the American Chemical Society. 136: 5900-3. PMID 24670208 DOI: 10.1021/Ja502205Q  0.678
2013 Evans RW, Zbieg JR, Zhu S, Li W, MacMillan DW. Simple catalytic mechanism for the direct coupling of α-carbonyls with functionalized amines: a one-step synthesis of Plavix. Journal of the American Chemical Society. 135: 16074-7. PMID 24107144 DOI: 10.1021/Ja4096472  0.785
2013 Cecere G, König CM, Alleva JL, MacMillan DW. Enantioselective direct α-amination of aldehydes via a photoredox mechanism: a strategy for asymmetric amine fragment coupling. Journal of the American Chemical Society. 135: 11521-4. PMID 23869694 DOI: 10.1021/Ja406181E  0.786
2013 Pirnot MT, Rankic DA, Martin DB, MacMillan DW. Photoredox activation for the direct β-arylation of ketones and aldehydes. Science (New York, N.Y.). 339: 1593-6. PMID 23539600 DOI: 10.1126/Science.1232993  0.838
2013 Prier CK, Rankic DA, MacMillan DW. Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. Chemical Reviews. 113: 5322-63. PMID 23509883 DOI: 10.1021/Cr300503R  0.814
2012 Jui NT, Garber JA, Finelli FG, MacMillan DW. Enantioselective organo-SOMO cycloadditions: a catalytic approach to complex pyrrolidines from olefins and aldehydes. Journal of the American Chemical Society. 134: 11400-3. PMID 22764834 DOI: 10.1021/Ja305076B  0.812
2012 Zhu S, MacMillan DW. Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation-cyclization cascade. Journal of the American Chemical Society. 134: 10815-8. PMID 22716914 DOI: 10.1021/Ja305100G  0.769
2012 Allen AE, Macmillan DW. Synergistic Catalysis: A Powerful Synthetic Strategy for New Reaction Development. Chemical Science (Royal Society of Chemistry : 2010). 2012: 633-658. PMID 22518271 DOI: 10.1039/C2Sc00907B  0.666
2012 Simonovich SP, Van Humbeck JF, Macmillan DW. A general approach to the enantioselective α-oxidation of aldehydes via synergistic catalysis. Chemical Science (Royal Society of Chemistry : 2010). 3: 58-61. PMID 22308217 DOI: 10.1039/C1Sc00556A  0.817
2011 Pham PV, Ashton K, Macmillan DW. The Intramolecular Asymmetric Allylation of Aldehydes via Organo-SOMO Catalysis: A Novel Approach to Ring Construction. Chemical Science (Royal Society of Chemistry : 2010). 2: 1470-1473. PMID 23087809 DOI: 10.1039/C1Sc00176K  0.805
2011 Knowles RR, Carpenter J, Blakey SB, Kayano A, Mangion IK, Sinz CJ, Macmillan DW. Total synthesis of diazonamide A. Chemical Science (Royal Society of Chemistry : 2010). 2011: 308-311. PMID 22860227 DOI: 10.1039/C0Sc00577K  0.813
2011 McNally A, Prier CK, MacMillan DW. Discovery of an α-amino C-H arylation reaction using the strategy of accelerated serendipity. Science (New York, N.Y.). 334: 1114-7. PMID 22116882 DOI: 10.1126/Science.1213920  0.809
2011 Harvey JS, Simonovich SP, Jamison CR, MacMillan DW. Enantioselective α-arylation of carbonyls via Cu(I)-bisoxazoline catalysis. Journal of the American Chemical Society. 133: 13782-5. PMID 21848265 DOI: 10.1021/Ja206050B  0.811
2011 Kwiatkowski P, Beeson TD, Conrad JC, MacMillan DW. Enantioselective organocatalytic α-fluorination of cyclic ketones. Journal of the American Chemical Society. 133: 1738-41. PMID 21247133 DOI: 10.1021/Ja111163U  0.832
2010 Reiter M, Torssell S, Lee S, Macmillan DW. The organocatalytic three-step total synthesis of (+)-frondosin B. Chemical Science (Royal Society of Chemistry : 2010). 1: 37-42. PMID 22299067 DOI: 10.1039/C0Sc00204F  0.554
2010 Jacobsen EN, MacMillan DW. Organocatalysis. Proceedings of the National Academy of Sciences of the United States of America. 107: 20618-9. PMID 21119011 DOI: 10.1073/Pnas.1016087107  0.537
2010 Mastracchio A, Warkentin AA, Walji AM, MacMillan DW. Direct and enantioselective {alpha}-allylation of ketones via singly occupied molecular orbital (SOMO) catalysis. Proceedings of the National Academy of Sciences of the United States of America. 107: 20648-51. PMID 20921367 DOI: 10.1073/Pnas.1002845107  0.844
2010 Devery JJ, Conrad JC, MacMillan DW, Flowers RA. Mechanistic complexity in organo-SOMO activation. Angewandte Chemie (International Ed. in English). 49: 6106-10. PMID 20632343 DOI: 10.1002/Anie.201001673  0.643
2010 Van Humbeck JF, Simonovich SP, Knowles RR, MacMillan DW. Concerning the mechanism of the FeCl3-catalyzed alpha-oxyamination of aldehydes: evidence for a non-SOMO activation pathway. Journal of the American Chemical Society. 132: 10012-4. PMID 20608675 DOI: 10.1021/Ja1043006  0.799
2010 MacMillan D, Van Humbeck J, Simonovich S, Knowles R. A Closed-Shell Mechanism Alternative for Sibi’s α-Oxyamination of Aldehydes Synfacts. 2010: 1191-1191. DOI: 10.1055/S-0030-1258679  0.789
2009 Borths CJ, Carrera DE, MacMillan DW. Development of a general, enantioselective organocatalytic Mukaiyama-Michael reaction with α,β-unsaturated aldehydes. Tetrahedron. 65: 6746-6753. PMID 25214677 DOI: 10.1016/J.Tet.2009.06.066  0.473
2009 Conrad JC, Kong J, Laforteza BN, MacMillan DW. Enantioselective alpha-arylation of aldehydes via organo-SOMO catalysis. An ortho-selective arylation reaction based on an open-shell pathway. Journal of the American Chemical Society. 131: 11640-1. PMID 19639997 DOI: 10.1021/Ja9026902  0.843
2009 Wilson JE, Casarez AD, MacMillan DW. Enantioselective aldehyde alpha-nitroalkylation via oxidative organocatalysis. Journal of the American Chemical Society. 131: 11332-4. PMID 19627154 DOI: 10.1021/Ja904504J  0.807
2009 Amatore M, Beeson TD, Brown SP, MacMillan DW. Enantioselective linchpin catalysis by SOMO catalysis: an approach to the asymmetric alpha-chlorination of aldehydes and terminal epoxide formation. Angewandte Chemie (International Ed. in English). 48: 5121-4. PMID 19526479 DOI: 10.1002/Anie.200901855  0.804
2008 Graham TH, Jones CM, Jui NT, MacMillan DW. Enantioselective organo-singly occupied molecular orbital catalysis: the carbo-oxidation of styrenes. Journal of the American Chemical Society. 130: 16494-5. PMID 19049447 DOI: 10.1021/Ja8075633  0.834
2008 Nicewicz DA, MacMillan DW. Merging photoredox catalysis with organocatalysis: the direct asymmetric alkylation of aldehydes. Science (New York, N.Y.). 322: 77-80. PMID 18772399 DOI: 10.1126/Science.1161976  0.729
2007 Lee S, MacMillan DW. Organocatalytic vinyl and Friedel-Crafts alkylations with trifluoroborate salts. Journal of the American Chemical Society. 129: 15438-9. PMID 18031044 DOI: 10.1021/Ja0767480  0.657
2006 MacMillan D, Lee S. Organocatalytic Epoxidation Using Hypervalent Iodine Reagents Synfacts. 2006: 1171-1171. DOI: 10.1055/S-2006-949459  0.469
2006 MacMillan D, Chen Y, Yoshida M. Enantioselective Amine Conjugate Addition Synfacts. 2006: 0949-0949. DOI: 10.1055/S-2006-949225  0.495
2005 Huang Y, Walji AM, Larsen CH, MacMillan DW. Enantioselective organo-cascade catalysis. Journal of the American Chemical Society. 127: 15051-3. PMID 16248643 DOI: 10.1021/Ja055545D  0.835
2004 Northrup AB, Mangion IK, Hettche F, MacMillan DW. Enantioselective organocatalytic direct aldol reactions of alpha-oxyaldehydes: step one in a two-step synthesis of carbohydrates. Angewandte Chemie (International Ed. in English). 43: 2152-4. PMID 15083470 DOI: 10.1002/Anie.200453716  0.772
2004 Austin JF, Kim SG, Sinz CJ, Xiao WJ, MacMillan DW. Enantioselective organocatalytic construction of pyrroloindolines by a cascade addition-cyclization strategy: synthesis of (-)-flustramine B. Proceedings of the National Academy of Sciences of the United States of America. 101: 5482-7. PMID 15067109 DOI: 10.1073/Pnas.0308177101  0.828
2004 Brochu MP, Brown SP, MacMillan DW. Direct and enantioselective organocatalytic alpha-chlorination of aldehydes. Journal of the American Chemical Society. 126: 4108-9. PMID 15053591 DOI: 10.1021/Ja049562Z  0.689
2003 Brown SP, Brochu MP, Sinz CJ, MacMillan DW. The direct and enantioselective organocatalytic alpha-oxidation of aldehydes. Journal of the American Chemical Society. 125: 10808-9. PMID 12952459 DOI: 10.1021/Ja037096S  0.665
2003 Blakey SB, MacMillan DW. The first Suzuki cross-couplings of aryltrimethylammonium salts. Journal of the American Chemical Society. 125: 6046-7. PMID 12785821 DOI: 10.1021/Ja034908B  0.705
2003 Brown SP, Goodwin NC, MacMillan DW. The first enantioselective organocatalytic Mukaiyama-Michael reaction: a direct method for the synthesis of enantioenriched gamma-butenolide architecture. Journal of the American Chemical Society. 125: 1192-4. PMID 12553821 DOI: 10.1021/Ja029095Q  0.84
2002 Lambert TH, MacMillan DW. Development of a new Lewis acid-catalyzed [3,3]-sigmatropic rearrangement: the allenoate-Claisen rearrangement. Journal of the American Chemical Society. 124: 13646-7. PMID 12431073 DOI: 10.1021/Ja028090Q  0.701
2002 Evans DA, Wu J, Masse CE, MacMillan DW. A general method for the enantioselective synthesis of pantolactone derivatives. Organic Letters. 4: 3379-82. PMID 12323023 DOI: 10.1021/Ol026489D  0.806
2002 Paras NA, MacMillan DW. The enantioselective organocatalytic 1,4-addition of electron-rich benzenes to alpha,beta-unsaturated aldehydes. Journal of the American Chemical Society. 124: 7894-5. PMID 12095321 DOI: 10.1021/Ja025981P  0.81
2002 Northrup AB, MacMillan DW. The first direct and enantioselective cross-aldol reaction of aldehydes. Journal of the American Chemical Society. 124: 6798-9. PMID 12059180 DOI: 10.1021/Ja0262378  0.778
2002 Northrup AB, MacMillan DW. The first general enantioselective catalytic Diels-Alder reaction with simple alpha,beta-unsaturated ketones. Journal of the American Chemical Society. 124: 2458-60. PMID 11890793 DOI: 10.1021/Ja017641U  0.805
2002 Austin JF, MacMillan DW. Enantioselective organocatalytic indole alkylations. Design of a new and highly effective chiral amine for iminium catalysis. Journal of the American Chemical Society. 124: 1172-3. PMID 11841277 DOI: 10.1021/Ja017255C  0.827
2001 MacMillan DW, Overman LE, Pennington LD. A general strategy for the synthesis of cladiellin diterpenes: enantioselective total syntheses of 6-acetoxycladiell-7(16),11-dien-3-ol (deacetoxyalcyonin acetate), cladiell-11-ene-3,6,7-triol, sclerophytin A, and the initially purported structure of sclerophytin A. Journal of the American Chemical Society. 123: 9033-44. PMID 11552811 DOI: 10.1021/Ja016351A  0.801
2001 Paras NA, MacMillan DW. New strategies in organic catalysis: the first enantioselective organocatalytic Friedel-Crafts alkylation. Journal of the American Chemical Society. 123: 4370-1. PMID 11457218 DOI: 10.1021/Ja015717G  0.815
2001 Yoon TP, MacMillan DW. Enantioselective Claisen rearrangements: development of a first generation asymmetric acyl-Claisen reaction. Journal of the American Chemical Society. 123: 2911-2. PMID 11456990 DOI: 10.1021/Ja015612D  0.723
2001 Dong VM, MacMillan DW. Design of a new cascade reaction for the construction of complex acyclic architecture: the tandem acyl-claisen rearrangement. Journal of the American Chemical Society. 123: 2448-9. PMID 11456904 DOI: 10.1021/Ja005925T  0.716
2001 Gallou F, MacMillan DW, Overman LE, Paquette LA, Pennington LD, Yang J. Enantioselective syntheses of authentic sclerophytin A, sclerophytin B, and cladiell-11-ene-3,6,7-triol. Organic Letters. 3: 135-7. PMID 11429857 DOI: 10.1021/Ol000345M  0.745
2001 Cohen F, MacMillan DW, Overman LE, Romero A. Stereoselection in the Prins-pinacol synthesis of acyltetrahydrofurans. Organic Letters. 3: 1225-8. PMID 11348200 DOI: 10.1021/Ol0157003  0.719
2000 Hanaki N, Link JT, MacMillan DW, Overman LE, Trankle WG, Wurster JA. Stereoselection in the prins-pinacol synthesis of 2,2-disubstituted 4-acyltetrahydrofurans. Enantioselective synthesis of (-)-citreoviral. Organic Letters. 2: 223-6. PMID 10814287 DOI: 10.1021/Ol991315Q  0.631
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