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John A. Porco, Jr. - Publications

Affiliations: 
Boston University, Boston, MA, United States 
Area:
synthesis of complex natural products
Website:
http://www.bu.edu/chemistry/faculty/porco/
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Year Citation  Score
2024 Ji K, Johnson RP, McNeely J, Al Faruk M, Porco JA. Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt. Journal of the American Chemical Society. PMID 38319883 DOI: 10.1021/jacs.3c13864  0.347
2023 Millimaci AM, Trilles RV, McNeely JH, Brown LE, Beeler AB, Porco JA. Synthesis of Neocannabinoids Using Controlled Friedel-Crafts Reactions. The Journal of Organic Chemistry. PMID 37657122 DOI: 10.1021/acs.joc.3c01362  0.512
2023 Naineni SK, Cencic R, Robert F, Brown L, Haque M, Scott-Talib J, Senechal P, Schmeing TM, Porco J, Pelletier J. Exploring the Targeting Spectrum of Rocaglates Among eIF4A Homologs. Rna (New York, N.Y.). PMID 36882295 DOI: 10.1261/rna.079318.122  0.46
2022 Shaashua L, Ben-Shmuel A, Pevsner-Fischer M, Friedman G, Levi-Galibov O, Nandakumar S, Barki D, Nevo R, Brown LE, Zhang W, Stein Y, Lior C, Kim HS, Bojmar L, Jarnagin WR, ... ... Porco JA, et al. BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. Nature Communications. 13: 6513. PMID 36316305 DOI: 10.1038/s41467-022-34081-3  0.4
2022 Yang F, Porco JA. Unified, Asymmetric Total Synthesis of the Asnovolins and Related Spiromeroterpenoids: A Fragment Coupling Approach. Journal of the American Chemical Society. PMID 35792599 DOI: 10.1021/jacs.2c05366  0.312
2022 Lehman SL, Wechsler T, Schwartz K, Brown LE, Porco JA, Devine WG, Pelletier J, Shankavaram UT, Camphausen K, Tofilon PJ. Inhibition of the translation initiation factor eIF4A enhances tumor cell radiosensitivity. Molecular Cancer Therapeutics. PMID 35732578 DOI: 10.1158/1535-7163.MCT-22-0037  0.465
2022 Praditya DF, Klöhn M, Brüggemann Y, Brown LE, Porco JA, Zhang W, Kinast V, Kirschning A, Vondran FWR, Todt D, Steinmann E. Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication. Antiviral Research. 105359. PMID 35728703 DOI: 10.1016/j.antiviral.2022.105359  0.493
2021 Xu W, Brown LE, Porco JA. Divergent, C-C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates. The Journal of Organic Chemistry. PMID 34730970 DOI: 10.1021/acs.joc.1c01848  0.566
2021 Chatterjee S, Yabaji SM, Rukhlenko OS, Bhattacharya B, Waligurski E, Vallavoju N, Ray S, Kholodenko BN, Brown LE, Beeler AB, Ivanov AR, Kobzik L, Porco JA, Kramnik I. Channeling macrophage polarization by rocaglates increases macrophage resistance to . Iscience. 24: 102845. PMID 34381970 DOI: 10.1016/j.isci.2021.102845  0.405
2020 Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA, Cuomo CA, Williams NS, Ibrahim AS, et al. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nature Communications. 11: 6429. PMID 33353950 DOI: 10.1038/s41467-020-20183-3  0.45
2020 Levi-Galibov O, Lavon H, Wassermann-Dozorets R, Pevsner-Fischer M, Mayer S, Wershof E, Stein Y, Brown LE, Zhang W, Friedman G, Nevo R, Golani O, Katz LH, Yaeger R, Laish I, ... Porco JA, et al. Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer. Nature Communications. 11: 6245. PMID 33288768 DOI: 10.1038/s41467-020-20054-x  0.411
2020 Boyce JH, Reisman BJ, Bachmann BO, Porco JA. Synthesis and Multiplexed Activity Profiling of Synthetic Acylphloroglucinol Scaffolds. Angewandte Chemie (International Ed. in English). PMID 32965753 DOI: 10.1002/anie.202010338  0.798
2020 Iyer KR, Whitesell L, Porco JA, Henkel T, Brown LE, Robbins N, Cowen LE. Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris. Mbio. 11. PMID 32156828 DOI: 10.1128/Mbio.03329-19  0.494
2020 Chu J, Zhang W, Cencic R, O'Connor PBF, Robert F, Devine WG, Selznick A, Henkel T, Merrick WC, Brown LE, Baranov PV, Porco JA, Pelletier J. Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F. Cell Reports. PMID 32101697 DOI: 10.1016/J.Celrep.2020.02.002  0.466
2020 Lehman SL, Wechsler T, Schwartz KR, Wahba A, Brown LE, Porco JA, Pelletier J, Camphausen K, Tofilon PJ. Abstract 6507: Inhibition of the translation initiation factor eIF4A1 enhances tumor cell radiosensitivity Cancer Research. 80: 6507-6507. DOI: 10.1158/1538-7445.Am2020-6507  0.469
2019 Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, ... ... Porco JA, et al. eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Nature Communications. 10: 5151. PMID 31723131 DOI: 10.1038/S41467-019-13086-5  0.456
2019 Chu J, Zhang W, Cencic R, Devine WG, Beglov D, Henkel T, Brown LE, Vajda S, Porco JA, Pelletier J. Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors. Cell Chemical Biology. PMID 31519508 DOI: 10.1016/J.Chembiol.2019.08.008  0.493
2019 Porco J, Powers Z, Scharf A, Cheng A, Yang F, Himmelbauer M, Mitsuhashi T, Barra L, Taniguchi Y, Kikuchi T, Fujita M, Abe I. Biomimetic Synthesis of Meroterpenoids by Dearomatization- Driven Polycyclization. Angewandte Chemie (International Ed. in English). PMID 31515901 DOI: 10.1002/Anie.201910710  0.314
2019 Zhang W, Chu J, Cyr AM, Yueh H, Brown LE, Wang TT, Pelletier J, Porco JA. Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors. Journal of the American Chemical Society. PMID 31310112 DOI: 10.1021/Jacs.9B06446  0.58
2019 Wen S, Boyce JH, Kandappa SK, Sivaguru J, Porco JA. Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (-)-Nemorosone and (-)-6- epi-Garcimultiflorone A. Journal of the American Chemical Society. PMID 31264859 DOI: 10.1021/Jacs.9B05600  0.777
2019 Zhang X, Bi C, Lu T, Zhang W, Yue T, Wang C, Tian T, Zhang X, Huang Y, Lunning M, Hao X, Brown LE, Devine WG, Vose J, Porco JA, et al. Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas. Leukemia. PMID 31171817 DOI: 10.1038/S41375-019-0503-Z  0.509
2019 Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling. Journal of Alzheimer's Disease : Jad. 67: 1089-1106. PMID 30776010 DOI: 10.3233/Jad-180923  0.444
2019 Itoua Maïga R, Cencic R, Chu J, Waller DD, Brown LE, Devine WG, Zhang W, Sebag M, Porco JA, Pelletier J. Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation. Scientific Reports. 9: 1265. PMID 30718665 DOI: 10.1038/S41598-018-37666-5  0.524
2019 Porco J, Qin XJ, Rauwolf T, Li PP, Li H, McNeely J, Hua Y, Liu HY. Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate. Angewandte Chemie (International Ed. in English). PMID 30681258 DOI: 10.1002/anie.201814421  0.314
2019 Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, ... Porco JA, et al. Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications. 10: 402. PMID 30679438 DOI: 10.1038/s41467-018-08248-w  0.462
2019 Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA, Kelley MR, Georgiadis MM. Discovery of macrocyclic inhibitors of Apurinic/apyrimidinic endonuclease 1. Journal of Medicinal Chemistry. PMID 30653918 DOI: 10.1021/Acs.Jmedchem.8B01529  0.787
2018 Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Porco JA, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/Acscentsci.8B00747  0.717
2018 Zhang W, Liu S, Maiga RI, Pelletier J, Brown LE, Wang TT, Porco JA. Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for HCV Infection. Journal of the American Chemical Society. PMID 30590924 DOI: 10.1021/Jacs.8B11477  0.551
2018 Smith MJ, Reichl KD, Escobar RA, Heavey T, Coker DF, Schaus SE, Porco JA. Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition. Journal of the American Chemical Society. PMID 30566336 DOI: 10.1021/Jacs.8B12520  0.798
2018 Nalli AD, Brown LE, Thomas CL, Sayers TJ, Porco JA, Henrich CJ. Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs. Scientific Reports. 8: 17519. PMID 30504817 DOI: 10.1038/S41598-018-35908-0  0.467
2018 Chennamadhavuni S, Panek JS, Porco JA, Brown LE. Diastereodivergent synthesis of chiral tetrahydropyrrolodiazepinediones via a one-pot intramolecular aza-Michael/lactamization sequence. The Journal of Organic Chemistry. PMID 30458107 DOI: 10.1021/Acs.Joc.8B02724  0.808
2018 Yang X, Jounaidi Y, Dai JB, Marte-Oquendo F, Halpin ES, Brown LE, Trilles R, Xu W, Daigle R, Yu B, Schaus SE, Porco JA, Forman SA. High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics. Anesthesiology. PMID 29894316 DOI: 10.1097/Aln.0000000000002281  0.527
2018 Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA, Pelletier J, Gros P. Rocaglates as dual-targeting agents for experimental cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463745 DOI: 10.1073/Pnas.1713000115  0.455
2018 Porco J, Qi C, Wang W, Reichl K, McNeely J. Total Synthesis of Aurofusarin: Studies of the Atropisomeric Stability of Bis-Naphthoquinones. Angewandte Chemie (International Ed. in English). PMID 29318760 DOI: 10.1002/Anie.201711535  0.642
2017 Porco J, Wang W, Clay A, Krishnan R, Lajkiewicz NJ, Brown LE, Sivaguru J. Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B via Selective ESIPT Photocycloaddition. Angewandte Chemie (International Ed. in English). PMID 28950418 DOI: 10.1002/Anie.201707539  0.789
2017 Reichl KD, Smith MJ, Song MK, Johnson R, Porco JA. Biomimetic Total Synthesis of (±)-Griffipavixanthone via a Cationic Cycloaddition-Cyclization Cascade. Journal of the American Chemical Society. PMID 28942643 DOI: 10.1021/Jacs.7B09265  0.329
2017 Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, ... ... Porco JA, et al. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Science Translational Medicine. 9. PMID 28490664 DOI: 10.1126/Scitranslmed.Aal2668  0.653
2016 Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes. European Journal of Organic Chemistry. 2016: 4800-4804. PMID 28082832 DOI: 10.1002/Ejoc.201601003  0.518
2016 Ingham OJ, Paranal RM, Smith WB, Escobar RA, Yueh H, Snyder T, Porco JA, Bradner JE, Beeler AB. Development of a Potent and Selective HDAC8 Inhibitor. Acs Medicinal Chemistry Letters. 7: 929-932. PMID 27774131 DOI: 10.1021/acsmedchemlett.6b00239  0.439
2016 Boyce JH, Eschenbrenner-Lux V, Porco JA. Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-Didehydroxyisogarcinol and (±)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis Acid-Controlled Cyclizations. Journal of the American Chemical Society. 138: 14789-14797. PMID 27744695 DOI: 10.1021/jacs.6b09727  0.785
2016 Porco J, Wang W, Cencic R, Whitesell L, Pelletier J. Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27338157 DOI: 10.1002/Chem.201602953  0.692
2016 Qi C, Xiong Y, Eschenbrenner-Lux V, Cong H, Porco JA. Asymmetric Syntheses of the Flavonoid Diels-Alder Natural Products Sanggenons C and O. Journal of the American Chemical Society. PMID 26735066 DOI: 10.1021/Jacs.5B12778  0.579
2016 Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes European Journal of Organic Chemistry. DOI: 10.1002/ejoc.201601003  0.522
2015 Liu S, Wang W, Brown LE, Qiu C, Lajkiewicz N, Zhao T, Zhou J, Porco JA, Wang TT. A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway. Ebiomedicine. 2: 1600-6. PMID 26870784 DOI: 10.1016/J.Ebiom.2015.09.018  0.773
2015 Chu J, Cencic R, Wang W, Porco JA, Pelletier J. Translation Inhibition by Rocaglates is Independent of eIF4E Phosphorylation Status. Molecular Cancer Therapeutics. PMID 26586722 DOI: 10.1158/1535-7163.Mct-15-0409  0.613
2015 Qin T, Iwata T, Ransom TT, Beutler JA, Porco JA. Syntheses of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of "Shapeshifting" Properties. Journal of the American Chemical Society. PMID 26544765 DOI: 10.1021/Jacs.5B09825  0.545
2015 Gervais A, Lazarski KE, Porco JA. Divergent Total Syntheses of Rhodomyrtosones A and B. The Journal of Organic Chemistry. 80: 9584-91. PMID 26351970 DOI: 10.1021/Acs.Joc.5B01570  0.593
2015 Yeo AT, Chennamadhavuni S, Whitty A, Porco JA, Gilmore TD. Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines. Molecules (Basel, Switzerland). 20: 7474-94. PMID 25915462 DOI: 10.3390/Molecules20057474  0.765
2015 Stone SD, Lajkiewicz NJ, Whitesell L, Hilmy A, Porco JA. Biomimetic kinetic resolution: highly enantio- and diastereoselective transfer hydrogenation of aglain ketones to access flavagline natural products. Journal of the American Chemical Society. 137: 525-30. PMID 25514979 DOI: 10.1021/Ja511728B  0.808
2015 Liu S, Wang W, Brown LE, Qiu C, Lajkiewicz N, Zhao T, Zhou J, Porco JA, Wang TT. A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway Ebiomedicine. DOI: 10.1016/j.ebiom.2015.09.018  0.777
2014 Yeung CS, Ziegler RE, Porco JA, Jacobsen EN. Thiourea-catalyzed enantioselective addition of indoles to pyrones: alkaloid cores with quaternary carbons. Journal of the American Chemical Society. 136: 13614-7. PMID 25213353 DOI: 10.1021/Ja508523G  0.307
2014 Zhu L, Qi J, Chiao CY, Zhang Q, Porco JA, Faller DV, Dai Y. Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities. International Journal of Oncology. 45: 2128-36. PMID 25189993 DOI: 10.3892/Ijo.2014.2639  0.468
2014 Grenning AJ, Boyce JH, Porco JA. Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation. Journal of the American Chemical Society. 136: 11799-804. PMID 25061804 DOI: 10.1021/ja5060302  0.814
2014 Villar EA, Beglov D, Chennamadhavuni S, Porco JA, Kozakov D, Vajda S, Whitty A. How proteins bind macrocycles. Nature Chemical Biology. 10: 723-31. PMID 25038790 DOI: 10.1038/Nchembio.1584  0.765
2014 Boyce JH, Porco JA. Asymmetric, stereodivergent synthesis of (-)-clusianone utilizing a biomimetic cationic cyclization. Angewandte Chemie (International Ed. in English). 53: 7832-7. PMID 24916169 DOI: 10.1002/anie.201404437  0.802
2014 Lajkiewicz NJ, Cognetta AB, Niphakis MJ, Cravatt BF, Porco JA. Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived β-lactone. Journal of the American Chemical Society. 136: 2659-64. PMID 24447064 DOI: 10.1021/Ja412431G  0.815
2014 Grenning AJ, Snyder JK, Porco JA. Remodeling of fumagillol: discovery of an oxygen-directed oxidative Mannich reaction. Organic Letters. 16: 792-5. PMID 24410175 DOI: 10.1021/Ol4035269  0.729
2014 Grenning AJ, Boyce JH, Porco JA. Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation Journal of the American Chemical Society. 136: 11799-11804. DOI: 10.1021/ja5060302  0.808
2013 Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA, Whitesell L, Lindquist S. Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science (New York, N.Y.). 341: 1238303. PMID 23869022 DOI: 10.1126/Science.1238303  0.567
2013 Winter DK, Endoma-Arias MA, Hudlicky T, Beutler JA, Porco JA. Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a tetrahydroxanthone analogue. The Journal of Organic Chemistry. 78: 7617-26. PMID 23834060 DOI: 10.1021/Jo401169Z  0.588
2013 Xiong Y, Schaus SE, Porco JA. Metal-catalyzed cascade rearrangements of 3-alkynyl flavone ethers. Organic Letters. 15: 1962-5. PMID 23574045 DOI: 10.1021/Ol400631B  0.501
2013 Winter DK, Sloman DL, Porco JA. Polycyclic xanthone natural products: structure, biological activity and chemical synthesis. Natural Product Reports. 30: 382-91. PMID 23334431 DOI: 10.1039/c3np20122h  0.756
2012 Dong S, Qin T, Hamel E, Beutler JA, Porco JA. Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienones and their biological evaluation. Journal of the American Chemical Society. 134: 19782-7. PMID 23110297 DOI: 10.1021/Ja3084708  0.681
2012 Leng B, Chichetti S, Su S, Beeler AB, Porco JA. Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations. Beilstein Journal of Organic Chemistry. 8: 1338-43. PMID 23019468 DOI: 10.3762/Bjoc.8.153  0.509
2012 Ziegler RE, Tan SJ, Kam TS, Porco JA. Development of an alkaloid-pyrone annulation: synthesis of pleiomaltinine. Angewandte Chemie (International Ed. in English). 51: 9348-51. PMID 22893619 DOI: 10.1002/anie.201204093  0.301
2012 Lajkiewicz NJ, Roche SP, Gerard B, Porco JA. Enantioselective photocycloaddition of 3-hydroxyflavones: total syntheses and absolute configuration assignments of (+)-ponapensin and (+)-elliptifoline. Journal of the American Chemical Society. 134: 13108-13. PMID 22804454 DOI: 10.1021/Ja305342F  0.804
2012 Little A, Porco JA. Total syntheses of graphisin A and sydowinin B. Organic Letters. 14: 2862-2865. PMID 22621405 DOI: 10.1021/Ol301107M  0.662
2012 Scully SS, Porco JA. Studies toward the synthesis of the epoxykinamycin FL-120B': discovery of a decarbonylative photocyclization. Organic Letters. 14: 2646-9. PMID 22571279 DOI: 10.1021/Ol3010563  0.676
2012 Zhang Q, Porco JA. Total Synthesis of (±)-7-epi-Nemorosone Organic Letters. 14: 1796-1799. PMID 22449198 DOI: 10.1021/Ol300386T  0.37
2012 Achard M, Beeler AB, Porco JA. Synthesis of azaphilone-based chemical libraries Acs Combinatorial Science. 14: 236-244. PMID 22330196 DOI: 10.1021/Co300002X  0.309
2012 Rodrigo CM, Cencic R, Roche SP, Pelletier J, Porco JA. Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies. Journal of Medicinal Chemistry. 55: 558-62. PMID 22128783 DOI: 10.1021/Jm201263K  0.673
2011 Scully SS, Porco JA. Asymmetric total synthesis of the epoxykinamycin FL-120 B'. Angewandte Chemie (International Ed. in English). 50: 9722-6. PMID 21953671 DOI: 10.1002/Anie.201104504  0.697
2011 Dong S, Cahill KJ, Kang MI, Colburn NH, Henrich CJ, Wilson JA, Beutler JA, Johnson RP, Porco JA. Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers. The Journal of Organic Chemistry. 76: 8944-54. PMID 21942286 DOI: 10.1021/Jo201658Y  0.634
2011 Ebada SS, Lajkiewicz N, Porco JA, Li-Weber M, Proksch P. Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae). Progress in the Chemistry of Organic Natural Products. 94: 1-58. PMID 21833837 DOI: 10.1007/978-3-7091-0748-5_1  0.758
2011 Brown LE, Dai P, Porco JA, Schaus SE. Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones. Organic Letters. 13: 4228-31. PMID 21749159 DOI: 10.1021/Ol2015658  0.541
2011 Medeiros MR, Schaus SE, Porco JA. A cycloisomerization/Friedel-Crafts alkylation strategy for the synthesis of pyrano[3,4-b]indoles. Organic Letters. 13: 4012-5. PMID 21740020 DOI: 10.1021/Ol201532K  0.329
2011 Sloman DL, Bacon JW, Porco JA. Total synthesis and absolute stereochemical assignment of kibdelone C. Journal of the American Chemical Society. 133: 9952-5. PMID 21648477 DOI: 10.1021/Ja203642N  0.778
2011 Wu J, Becerril J, Lian Y, Davies HM, Porco JA, Panek JS. Sequential transformations to access polycyclic chemotypes: asymmetric crotylation and metal carbenoid reactions. Angewandte Chemie (International Ed. in English). 50: 5938-42. PMID 21560214 DOI: 10.1002/Anie.201101366  0.43
2011 Roche SP, Porco JA. Dearomatization strategies in the synthesis of complex natural products. Angewandte Chemie (International Ed. in English). 50: 4068-93. PMID 21506209 DOI: 10.1002/anie.201006017  0.65
2011 Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, ... ... Porco JA, et al. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proceedings of the National Academy of Sciences of the United States of America. 108: 6775-80. PMID 21498685 DOI: 10.1073/Pnas.1017666108  0.485
2011 Germain AR, Bruggemeyer DM, Zhu J, Genet C, O'Brien P, Porco JA. Synthesis of the azaphilones (+)-sclerotiorin and (+)-8-O-methylsclerotiorinamine utilizing (+)-sparteine surrogates in copper-mediated oxidative dearomatization. The Journal of Organic Chemistry. 76: 2577-84. PMID 21401026 DOI: 10.1021/Jo102448N  0.661
2011 Sloman DL, Mitasev B, Scully SS, Beutler JA, Porco JA. Synthesis and biological evaluation of ABCD ring fragments of the kibdelones. Angewandte Chemie (International Ed. in English). 50: 2511-5. PMID 21370327 DOI: 10.1002/Anie.201007613  0.777
2011 Xia B, Gerard B, Solano DM, Wan J, Jones G, Porco JA. ESIPT-mediated photocycloadditions of 3-hydroxyquinolinones: development of a fluorescence quenching assay for reaction screening. Organic Letters. 13: 1346-9. PMID 21338078 DOI: 10.1021/Ol200032F  0.506
2010 Zhang Q, Mitasev B, Qi J, Porco JA. Total synthesis of plukenetione A. Journal of the American Chemical Society. 132: 14212-5. PMID 20843036 DOI: 10.1021/Ja105784S  0.786
2010 Qi J, Beeler AB, Zhang Q, Porco JA. Catalytic enantioselective alkylative dearomatization-annulation: total synthesis and absolute configuration assignment of hyperibone K. Journal of the American Chemical Society. 132: 13642-4. PMID 20831187 DOI: 10.1021/Ja1057828  0.485
2010 Roche SP, Cencic R, Pelletier J, Porco JA. Biomimetic photocycloaddition of 3-hydroxyflavones: synthesis and evaluation of rocaglate derivatives as inhibitors of eukaryotic translation. Angewandte Chemie (International Ed. in English). 49: 6533-8. PMID 20687060 DOI: 10.1002/Anie.201003212  0.625
2010 Marié JC, Xiong Y, Min GK, Yeager AR, Taniguchi T, Berova N, Schaus SE, Porco JA. Enantioselective synthesis of 3,4-chromanediones via asymmetric rearrangement of 3-allyloxyflavones. The Journal of Organic Chemistry. 75: 4584-90. PMID 20527786 DOI: 10.1021/Jo100889C  0.561
2009 Mitasev B, Porco JA. Manganese(III)-mediated transformations of phloroglucinols: a formal oxidative [4 + 2] cycloaddition leading to bicyclo[2.2.2]octadiones. Organic Letters. 11: 2285-8. PMID 19415907 DOI: 10.1021/ol900590t  0.732
2009 Dong S, Hamel E, Bai R, Covell DG, Beutler JA, Porco JA. Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor. Angewandte Chemie (International Ed. in English). 48: 1494-7. PMID 19140149 DOI: 10.1002/Anie.200805486  0.677
2009 Han C, Rangarajan S, Voukides AC, Beeler AB, Johnson R, Porco JA. Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams. Organic Letters. 11: 413-6. PMID 19102683 DOI: 10.1021/Ol802729F  0.555
2009 Dong S, Hamel E, Bai R, Covell DG, Beutler JA, Porco JA. Synthesis of (+)-Chamaecypanone C Synfacts. 2009: 829-829. DOI: 10.1055/S-0029-1217508  0.546
2008 Bordeleau ME, Robert F, Gerard B, Lindqvist L, Chen SM, Wendel HG, Brem B, Greger H, Lowe SW, Porco JA, Pelletier J. Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. The Journal of Clinical Investigation. 118: 2651-60. PMID 18551192 DOI: 10.1172/Jci34753  0.564
2008 Dong S, Zhu J, Porco JA. Enantioselective synthesis of bicyclo[2.2.2]octenones using a copper-mediated oxidative dearomatization/[4 + 2] dimerization cascade. Journal of the American Chemical Society. 130: 2738-9. PMID 18266375 DOI: 10.1021/Ja711018Z  0.652
2008 Porco JA, Gerard B. Chapter 6 A biomimetic approach to the rocaglamides employing photogeneration of oxidopyryliums derived from 3-hydroxyflavones Strategies and Tactics in Organic Synthesis. 7. DOI: 10.1016/S1874-6004(08)80010-X  0.531
2007 Su S, Porco JA. 1,2-dihydroisoquinolines as templates for cascade reactions to access isoquinoline alkaloid frameworks. Organic Letters. 9: 4983-6. PMID 17958365 DOI: 10.1021/Ol702176H  0.513
2007 Qi J, Porco JA. Rapid access to polyprenylated phloroglucinols via alkylative dearomatization-annulation: total synthesis of (+/-)-clusianone(1). Journal of the American Chemical Society. 129: 12682-3. PMID 17902679 DOI: 10.1021/Ja0762339  0.491
2007 Gerard B, Cencic R, Pelletier J, Porco JA. Enantioselective synthesis of the complex rocaglate (-)-silvestrol. Angewandte Chemie (International Ed. in English). 46: 7831-4. PMID 17806093 DOI: 10.1002/Anie.200702707  0.589
2007 Peng LF, Kim SS, Matchacheep S, Lei X, Su S, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB, Porco JA, Schreiber SL, Chung RT. Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Antimicrobial Agents and Chemotherapy. 51: 3756-9. PMID 17682098 DOI: 10.1128/Aac.00233-07  0.758
2007 Su S, Porco JA. Synthesis of pyrrolo-isoquinolines related to the lamellarins using silver-catalyzed cycloisomerization/dipolar cycloaddition. Journal of the American Chemical Society. 129: 7744-5. PMID 17539647 DOI: 10.1021/Ja072737V  0.56
2007 Han C, Porco JA. Synthesis of carbamates and ureas using Zr(IV)-catalyzed exchange processes. Organic Letters. 9: 1517-20. PMID 17358074 DOI: 10.1021/ol0702728  0.499
2007 Beeler AB, Su S, Singleton CA, Porco JA. Discovery of chemical reactions through multidimensional screening. Journal of the American Chemical Society. 129: 1413-9. PMID 17263426 DOI: 10.1021/Ja0674744  0.479
2007 Zhou Y, Porco JA, Snyder JK. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations. Organic Letters. 9: 393-6. PMID 17249770 DOI: 10.1021/Ol0625280  0.34
2006 Lei X, Porco JA. Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1. Journal of the American Chemical Society. 128: 14790-1. PMID 17105273 DOI: 10.1021/Ja066621V  0.542
2006 Zhu J, Porco JA. Asymmetric syntheses of (-)-mitorubrin and related azaphilone natural products. Organic Letters. 8: 5169-71. PMID 17048870 DOI: 10.1021/Ol062233M  0.527
2006 Porco JA, Su S, Lei X, Bardhan S, Rychnovsky SD. Total synthesis and structure assignment of (+)-hexacyclinol. Angewandte Chemie (International Ed. in English). 45: 5790-2. PMID 16871643 DOI: 10.1002/Anie.200602854  0.782
2006 Kleinke AS, Li C, Rabasso N, Porco JA. Total synthesis of the interleukin-1beta converting enzyme inhibitor EI-1941-2 using tandem oxa-electrocyclization/oxidation1. Organic Letters. 8: 2847-50. PMID 16774272 DOI: 10.1021/Ol060954F  0.773
2006 Gerard B, Sangji S, O'Leary DJ, Porco JA. Enantioselective photocycloaddition mediated by chiral Brønsted acids: asymmetric synthesis of the rocaglamides. Journal of the American Chemical Society. 128: 7754-5. PMID 16771486 DOI: 10.1021/Ja062621J  0.615
2006 Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA, Lowell BB. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metabolism. 3: 417-27. PMID 16753577 DOI: 10.1016/J.Cmet.2006.04.010  0.49
2006 Bardhan S, Schmitt DC, Porco JA. Total synthesis and stereochemical assignment of the spiroisoxazoline natural product (+)-calafianin. Organic Letters. 8: 927-30. PMID 16494476 DOI: 10.1021/Ol053115M  0.654
2006 Liang MC, Bardhan S, Pace EA, Rosman D, Beutler JA, Porco JA, Gilmore TD. Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity. Biochemical Pharmacology. 71: 634-45. PMID 16360644 DOI: 10.1016/J.Bcp.2005.11.013  0.676
2006 Liang MC, Bardhan S, Porco JA, Gilmore TD. The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an IkappaBalpha-deficient diffuse large B-cell lymphoma cell line. Cancer Letters. 241: 69-78. PMID 16289774 DOI: 10.1016/J.Canlet.2005.10.004  0.558
2006 Gerard B, Ryan J, Beeler AB, Porco JA. Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes Tetrahedron. 62: 6405-6411. DOI: 10.1016/J.Tet.2006.04.025  0.55
2005 Lei X, Zaarur N, Sherman MY, Porco JA. Stereocontrolled synthesis of a complex library via elaboration of angular epoxyquinol scaffolds. The Journal of Organic Chemistry. 70: 6474-83. PMID 16050712 DOI: 10.1021/Jo050956Y  0.553
2005 Li C, Porco JA. Synthesis of epoxyquinol A and related molecules: probing chemical reactivity of epoxyquinol dimers and 2H-pyran precursors. The Journal of Organic Chemistry. 70: 6053-65. PMID 16018703 DOI: 10.1021/Jo050897O  0.666
2005 Han C, Lee JP, Lobkovsky E, Porco JA. Catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes. Journal of the American Chemical Society. 127: 10039-44. PMID 16011366 DOI: 10.1021/Ja0527976  0.478
2005 Zhu J, Grigoriadis NP, Lee JP, Porco JA. Synthesis of the azaphilones using copper-mediated enantioselective oxidative dearomatization. Journal of the American Chemical Society. 127: 9342-3. PMID 15984841 DOI: 10.1021/Ja052049G  0.51
2005 Su S, Acquilano DE, Arumugasamy J, Beeler AB, Eastwood EL, Giguere JR, Lan P, Lei X, Min GK, Yeager AR, Zhou Y, Panek JS, Snyder JK, Schaus SE, Porco JA. Convergent synthesis of a complex oxime library using chemical domain shuffling. Organic Letters. 7: 2751-4. PMID 15957938 DOI: 10.1021/Ol051023R  0.642
2005 Shen R, Inoue T, Forgac M, Porco JA. Synthesis of photoactivatable acyclic analogues of the lobatamides. The Journal of Organic Chemistry. 70: 3686-92. PMID 15845008 DOI: 10.1021/Jo0477751  0.565
2005 Wang X, Porco JA. Synthesis of the Tetracyclic Core of the Tetrapetalones through Transannular Oxidative [4+3] Cyclization Angewandte Chemie. 44: 3067-3071. PMID 15832389 DOI: 10.1002/Anie.200500247  0.435
2005 Porco J, Zhu J, Grigoriadis N, Lee J. Copper-Mediated Synthesis of Azaphilones Synfacts. 2006: 0001-0001. DOI: 10.1055/s-2005-921655  0.484
2005 Gerard B, Jones aG, Porco JA. A Biomimetic Approach to the Rocaglamides Employing Photogeneration of Oxidopyryliums Derived from 3-Hydroxyflavones [J. Am. Chem. Soc. 2004, 126, 13620−13621]. Journal of the American Chemical Society. 127: 1334-1334. DOI: 10.1021/Ja042481I  0.519
2004 Gerard B, Jones Ii G, Porco JA. A biomimetic approach to the rocaglamides employing photogeneration of oxidopyryliums derived from 3-hydroxyflavones. Journal of the American Chemical Society. 126: 13620-1. PMID 15493911 DOI: 10.1021/Ja044798O  0.579
2004 Wang X, Bowman EJ, Bowman BJ, Porco JA. Total synthesis of the salicylate enamide macrolide oximidine III: application of relay ring-closing metathesis. Angewandte Chemie (International Ed. in English). 43: 3601-5. PMID 15293258 DOI: 10.1002/Anie.200460042  0.44
2004 Zhu J, Germain AR, Porco JA. Synthesis of azaphilones and related molecules by employing cycloisomerization of o-alkynylbenzaldehydes. Angewandte Chemie (International Ed. in English). 43: 1239-43. PMID 14991787 DOI: 10.1002/Anie.200353037  0.647
2004 Lei X, Porco JA. Synthesis of a polymer-supported anthracene and its application as a dienophile scavenger. Organic Letters. 6: 795-8. PMID 14986977 DOI: 10.1021/Ol036502+  0.435
2004 Li C, Porco JA. Synthesis of the epoxyquinol dimer RKB-3564 D: utilization of an alkoxysilanol to promote [4 + 4] dimerization. Journal of the American Chemical Society. 126: 1310-1. PMID 14759167 DOI: 10.1021/Ja039543+  0.66
2004 Han C, Shen R, Su S, Porco JA. Copper-mediated synthesis of N-acyl vinylogous carbamic acids and derivatives: synthesis of the antibiotic CJ-15,801. Organic Letters. 6: 27-30. PMID 14703342 DOI: 10.1021/Ol0360041  0.726
2004 Su S, Giguere JR, Schaus SE, Porco JA. Synthesis of complex alkoxyamines using a polymer-supported N-hydroxyphthalimide Tetrahedron. 60: 8645-8657. DOI: 10.1016/J.Tet.2004.05.109  0.469
2003 Lei X, Johnson RP, Porco JA. Total synthesis of the ubiquitin-activating enzyme inhibitor (+)-panepophenanthrin. Angewandte Chemie (International Ed. in English). 42: 3913-7. PMID 12949867 DOI: 10.1002/Anie.200351862  0.497
2003 Shen R, Lin CT, Bowman EJ, Bowman BJ, Porco JA. Lobatamide C: total synthesis, stereochemical assignment, preparation of simplified analogues, and V-ATPase inhibition studies. Journal of the American Chemical Society. 125: 7889-901. PMID 12823009 DOI: 10.1021/Ja0352350  0.593
2003 Liang MC, Bardhan S, Li C, Pace EA, Porco JA, Gilmore TD. Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase. Molecular Pharmacology. 64: 123-31. PMID 12815168 DOI: 10.1124/Mol.64.1.123  0.746
2003 Wang X, Porco JA. Total synthesis of the salicylate enamide macrolide oximidine II. Journal of the American Chemical Society. 125: 6040-6041. PMID 12785818 DOI: 10.1021/Ja034030O  0.471
2003 Li C, Johnson RP, Porco JA. Total synthesis of the quinone epoxide dimer (+)-torreyanic acid: application of a biomimetic oxidation/electrocyclization/Diels-Alder dimerization cascade. Journal of the American Chemical Society. 125: 5095-106. PMID 12708860 DOI: 10.1021/Ja021396C  0.706
2003 Su S, Kakeya H, Osada H, Porco JA. Synthesis and cell cycle inhibition of the peptide enamide natural products terpeptin and the aspergillamides Tetrahedron. 59: 8931-8946. DOI: 10.1016/J.Tet.2003.04.005  0.574
2002 Li C, Bardhan S, Pace EA, Liang MC, Gilmore TD, Porco JA. Angiogenesis inhibitor epoxyquinol a: total synthesis and inhibition of transcription factor NF-kappaB. Organic Letters. 4: 3267-70. PMID 12227765 DOI: 10.1021/Ol026513N  0.769
2002 Shen R, Lin CT, Bowman EJ, Bowman BJ, Porco JA. Synthesis and V-ATPase inhibition of simplified lobatamide analogues. Organic Letters. 4: 3103-6. PMID 12201727 DOI: 10.1021/Ol026391Z  0.565
2002 Shen R, Lin CT, Porco JA. Total synthesis and stereochemical assignment of the salicylate antitumor macrolide lobatamide C(1). Journal of the American Chemical Society. 124: 5650-1. PMID 12010033 DOI: 10.1021/Ja026025A  0.597
2002 Kulkarni BA, Roth GP, Lobkovsky E, Porco JA. Combinatorial synthesis of natural product-like molecules using a first-generation spiroketal scaffold. Journal of Combinatorial Chemistry. 4: 56-72. PMID 11831883 DOI: 10.1021/CC010047W  0.321
2002 Li C, Bardhan S, Pace EA, Liang MC, Gilmore TD, Porco JA. Angiogenesis inhibitor epoxyquinol A: Total synthesis and inhibition of transcription factor NF-κB Organic Letters. 4: 3267-3270. DOI: 10.1021/ol026513n  0.745
2001 Wang X, Porco JA. Modification of C-terminal peptides to form peptide enamides: synthesis of chondriamides A and C. Journal of Organic Chemistry. 66: 8215-8221. PMID 11722228 DOI: 10.1021/Jo0158027  0.35
2001 Li C, Pace EA, Liang MC, Lobkovsky E, Gilmore TD, Porco JA. Total synthesis of the NF-kappa B inhibitor (-)-cycloepoxydon: utilization of tartrate-mediated nucleophilic epoxidation. Journal of the American Chemical Society. 123: 11308-9. PMID 11697981 DOI: 10.1021/Ja0169769  0.685
2001 Hu Y, Li C, Kulkarni BA, Strobel G, Lobkovsky E, Torczynski RM, Porco JA. Exploring chemical diversity of epoxyquinoid natural products: synthesis and biological activity of (-)-jesterone and related molecules. Organic Letters. 3: 1649-1652. PMID 11405677 DOI: 10.1021/Ol0159367  0.732
2000 Wang X, Parlow JJ, Porco JA. Parallel Synthesis and Purification Using Anthracene-Tagged Substrates Organic Letters. 2: 3509-3512. PMID 11082021 DOI: 10.1021/Ol0065625  0.44
1995 Wong C, Provencher L, Porco JA, Jung S, Wang Y, Chen L, Wang R, Steensma DH. Synthesis and Evaluation of Homoaza Sugars as Glycosidase Inhibitors Journal of Organic Chemistry. 60: 1492-1501. DOI: 10.1021/Jo00111A007  0.436
1988 Schreiber SL, Desmaele D, Porco JA. On the use of unsymmetrically substituted furans in the furan-carbonyl photocycloaddition reaction: Synthesis of a kadsurenone-ginkgolide hybrid Tetrahedron Letters. 29: 6689-6692. DOI: 10.1016/S0040-4039(00)82429-6  0.697
Low-probability matches (unlikely to be authored by this person)
2015 Qin T, Skraba-Joiner SL, Khalil ZG, Johnson RP, Capon RJ, Porco JA. Atropselective syntheses of (-) and (+) rugulotrosin A utilizing point-to-axial chirality transfer. Nature Chemistry. 7: 234-40. PMID 25698333 DOI: 10.1038/Nchem.2173  0.297
2011 Balthaser BR, Maloney MC, Beeler AB, Porco JA, Snyder JK. Remodelling of the natural product fumagillol employing a reaction discovery approach. Nature Chemistry. 3: 969-73. PMID 22213919 DOI: 10.1038/Nchem.1178  0.294
2007 Yu C, Porco JA, Panek JS. Stereochemical and skeletal diversity employing pipecolate ester scaffolds Organic Letters. 9: 1529-1532. PMID 17367153 DOI: 10.1021/Ol070321G  0.291
1991 Kajimoto T, Liu KKC, Pederson RL, Zhong Z, Ichikawa Y, Porco JA, Wong CH. Enzyme-catalyzed aldol condensation for asymmetric synthesis of azasugars: synthesis, evaluation, and modeling of glycosidase inhibitors Journal of the American Chemical Society. 113: 6187-6196. DOI: 10.1021/JA00016A039  0.285
2009 Castaldi MP, Troast DM, Porco JA. Stereoselective synthesis of spirocyclic oxindoles via Prins cyclizations. Organic Letters. 11: 3362-5. PMID 19719184 DOI: 10.1021/ol901201k  0.283
2005 Beeler AB, Acquilano DE, Su Q, Yan F, Roth BL, Panek JS, Porco JA. Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters. Journal of Combinatorial Chemistry. 7: 673-81. PMID 16153061 DOI: 10.1021/Cc050064B  0.282
2011 Qin T, Johnson RP, Porco JA. Vinylogous addition of siloxyfurans to benzopyryliums: a concise approach to the tetrahydroxanthone natural products. Journal of the American Chemical Society. 133: 1714-7. PMID 21265529 DOI: 10.1021/Ja110698N  0.276
2018 Wu X, Iwata T, Scharf A, Qin T, Reichl KD, Porco JA. Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling. Journal of the American Chemical Society. PMID 29658717 DOI: 10.1021/Jacs.8B02535  0.268
2008 Troast DM, Yuan J, Porco JA. Studies Toward the Synthesis of (-)-Zampanolide: Preparation of the Macrocyclic Core. Advanced Synthesis & Catalysis. 350: 1701-1711. PMID 23543877 DOI: 10.1002/adsc.200800247  0.267
2005 Beeler AB, Schaus SE, Porco JA. Chemical library synthesis using convergent approaches. Current Opinion in Chemical Biology. 9: 277-84. PMID 15939329 DOI: 10.1016/J.Cbpa.2005.04.005  0.266
2014 Qin T, Porco JA. Total syntheses of secalonic acids A and D Angewandte Chemie - International Edition. 53: 3107-3110. DOI: 10.1002/anie.201311260  0.26
2019 Purgett TJ, Dyer MW, Bickel B, McNeely J, Porco JA. Gold(I)-Mediated Cycloisomerization/Cycloaddition Enables Bioinspired Syntheses of Neonectrolides B-E and Analogs. Journal of the American Chemical Society. PMID 31469554 DOI: 10.1021/jacs.9b06355  0.259
2000 Porco JA. Organic synthesis using chemical tags: the third Leg of parallel synthesis. Combinatorial Chemistry & High Throughput Screening. 3: 93-102. PMID 10788579 DOI: 10.2174/1386207003331715  0.254
1998 Porco JA, Deegan TL, Devonport W, Gooding OW, Labadie JW, MacDonald AA, Newcomb WS, Van Eikeren P. Automated chemical synthesis: Chemistry development on the nautilus 2400(TM) Drugs of the Future. 23: 71-78. DOI: 10.1358/dof.1998.023.01.858432  0.251
2011 Goodell JR, Poole JL, Beeler AB, Aubé J, Porco JA. Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes. The Journal of Organic Chemistry. 76: 9792-800. PMID 22007996 DOI: 10.1021/Jo2018922  0.25
2016 Kärkäs MD, Porco JA, Stephenson CR. Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. Chemical Reviews. PMID 27120289 DOI: 10.1021/Acs.Chemrev.5B00760  0.24
2003 Su Q, Beeler AB, Lobkovsky E, Porco JA, Panek JS. Stereochemical diversity through cyclodimerization: Synthesis of polyketide-like macrodiolides Organic Letters. 5: 2149-2152. PMID 12790551 DOI: 10.1021/Ol034608Z  0.24
2005 Kesavan S, Su Q, Shao J, Porco JA, Panek JS. Enantioselective synthesis of linear polypropionate arrays using anthracene-tagged organosilanes Organic Letters. 7: 4435-4438. PMID 16178552 DOI: 10.1021/Ol0516723  0.238
2007 Kesavan S, Panek JS, Porco JA. Preparation of alkylidene indane and related scaffolds and their further elaboration to novel chemotypes Organic Letters. 9: 5203-5206. PMID 17997565 DOI: 10.1021/Ol7023778  0.235
2014 Qin T, Porco JA. Total syntheses of secalonic acids A and D. Angewandte Chemie (International Ed. in English). 53: 3107-10. PMID 24519991 DOI: 10.1002/anie.201311260  0.235
2002 Troast DM, Porco JA. Studies toward the synthesis of (-)-zampanolide: preparation of N-acyl hemiaminal model systems. Organic Letters. 4: 991-4. PMID 11893204  0.229
2010 Liang B, Kalidindi S, Porco JA, Stephenson CR. Multicomponent reaction discovery: three-component synthesis of spirooxindoles. Organic Letters. 12: 572-5. PMID 20050598 DOI: 10.1021/Ol902764K  0.229
2013 Qi C, Cong H, Cahill KJ, Müller P, Johnson RP, Porco JA. Biomimetic dehydrogenative Diels-Alder cycloadditions: total syntheses of brosimones A and B. Angewandte Chemie (International Ed. in English). 52: 8345-8. PMID 23818217 DOI: 10.1002/Anie.201302847  0.226
2010 Medeiros MR, Narayan RS, McDougal NT, Schaus SE, Porco JA. Skeletal diversity via cationic rearrangements of substituted dihydropyrans. Organic Letters. 12: 3222-5. PMID 20550144 DOI: 10.1021/Ol101144K  0.226
2006 Dandapani S, Lan P, Beeler AB, Beischel S, Abbas A, Roth BL, Porco JA, Panek JS. Convergent synthesis of complex diketopiperazines derived from pipecolic acid scaffolds and parallel screening against GPCR targets. The Journal of Organic Chemistry. 71: 8934-45. PMID 17081025 DOI: 10.1021/jo061758p  0.225
2012 Cong H, Porco JA. Total synthesis of (±)-sorocenol B employing nanoparticle catalysis. Organic Letters. 14: 2516-9. PMID 22553903 DOI: 10.1021/ol300800r  0.225
2006 Yeager AR, Min GK, Porco JA, Schaus SE. Exploring skeletal diversity via ring contraction of glycal-derived scaffolds. Organic Letters. 8: 5065-8. PMID 17048844 DOI: 10.1021/Ol0618252  0.223
2021 Iyer K, Camara K, Daniel-Ivad M, Revie N, Lou J, Li S, Trilles R, Elardo S, Yashiroda Y, Fossen J, Marchillo K, Liu Z, Singh S, Muñoz J, Hu Kim S, ... ... Porco J, et al. Exploiting diverse chemical collections to uncover novel antifungals Access Microbiology. 3. DOI: 10.1099/acmi.cc2021.po0006  0.222
2011 Deb Majumdar I, Devanabanda A, Fox B, Schwartzman J, Cong H, Porco JA, Weber HC. Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro. Biochemical and Biophysical Research Communications. 416: 397-402. PMID 22120630 DOI: 10.1016/j.bbrc.2011.11.052  0.222
2012 Fox B, Majumdar ID, Devanabanda A, Cong H, Porco JA, Weber HC. Sa1785 Synthetic Prenylflavonoid Natural Product Panduratin a Possesses Cytotoxic Activities Against Pancreatic Cancer Cells and Inhibits Cysteine Cathepsin Proteases In Vitro Gastroenterology. 142: S-325. DOI: 10.1016/S0016-5085(12)61222-0  0.219
2018 Zhang X, Bi C, Lu T, Yue T, Zhang W, Zhang X, Cheng W, Tian T, Lunning MA, Vose JM, Pelletier J, Porco JA, Tao J, Fu K. Targeting Oncoprotein Translation with Rocaglates in MYC-Driven Lymphoma Blood. 132: 38-38. DOI: 10.1182/Blood-2018-99-117659  0.216
2010 Treece JL, Goodell JR, Vander Velde D, Porco JA, Aubé J. Reaction discovery using microfluidic-based multidimensional screening of polycyclic iminium ethers. The Journal of Organic Chemistry. 75: 2028-38. PMID 20163127 DOI: 10.1021/Jo100087H  0.212
2010 Kota S, Scampavia L, Spicer T, Beeler AB, Takahashi V, Snyder JK, Porco JA, Hodder P, Strosberg AD. A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization. Assay and Drug Development Technologies. 8: 96-105. PMID 20035614 DOI: 10.1089/Adt.2009.0217  0.21
2010 Goodell JR, Leng B, Snyder TK, Beeler AB, Porco JA. Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones. Synthesis. 2010: 2254-2270. PMID 25132691 DOI: 10.1055/S-0029-1218813  0.209
2021 Nishida Y, Zhao R, Heese LE, Akiyama H, Patel S, Jaeger AM, Jacamo RO, Kojima K, Ma MCJ, Ruvolo VR, Chachad D, Devine W, Lindquist S, Davis RE, Porco JA, et al. Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML. Leukemia. PMID 34127794 DOI: 10.1038/s41375-021-01308-z  0.202
2005 Kesavan S, Su Q, Shao J, Porco JA, Panek JS. Enantioselective Synthesis of Linear Polypropionate Arrays Synfacts. 2005: 352-352. DOI: 10.1055/S-2005-921606  0.201
2013 Bos PH, Antalek MT, Porco JA, Stephenson CR. Tandem dienone photorearrangement-cycloaddition for the rapid generation of molecular complexity. Journal of the American Chemical Society. 135: 17978-82. PMID 24161069 DOI: 10.1021/Ja409992M  0.2
2020 Abe I, Mitsuhashi T, Barra L, Powers Z, Kojasoy V, Cheng A, Yang F, Taniguchi Y, Kikuchi T, Fujita M, Tantillo DJ, Porco JA. Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids. Angewandte Chemie (International Ed. in English). PMID 32931152 DOI: 10.1002/Anie.202011171  0.198
2024 Fallah S, Duncan D, Reichl KD, Smith MJ, Wang W, Porco JA, Brown LE, Whitesell L, Robbins N, Cowen LE. A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen . Microbiology Spectrum. e0409523. PMID 38376363 DOI: 10.1128/spectrum.04095-23  0.196
2010 Cong H, Becker CF, Elliott SJ, Grinstaff MW, Porco JA. Silver nanoparticle-catalyzed Diels-Alder cycloadditions of 2'-hydroxychalcones. Journal of the American Chemical Society. 132: 7514-8. PMID 20443601 DOI: 10.1021/Ja102482B  0.195
2014 Robert F, Roman W, Bramoullé A, Fellmann C, Roulston A, Shustik C, Porco JA, Shore GC, Sebag M, Pelletier J. Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America. 111: 13421-6. PMID 25197055 DOI: 10.1073/Pnas.1402650111  0.195
2010 Kinoshita H, Ingham OJ, Ong WW, Beeler AB, Porco JA. Tandem processes identified from reaction screening: nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation. Journal of the American Chemical Society. 132: 6412-8. PMID 20394364 DOI: 10.1021/ja100346w  0.192
2014 Qi C, Qin T, Suzuki D, Porco JA. Total synthesis and stereochemical assignment of (±)-sorbiterrin A. Journal of the American Chemical Society. 136: 3374-7. PMID 24547688 DOI: 10.1021/ja500854q  0.191
2007 Porco JA. Organic chemistry: synthesis undressed. Nature. 446: 383-5. PMID 17377569 DOI: 10.1038/446383a  0.189
2007 Teng X, Keys H, Jeevanandam A, Porco JA, Degterev A, Yuan J, Cuny GD. Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 6836-40. PMID 17964153 DOI: 10.1016/J.Bmcl.2007.10.024  0.186
2010 Cencic R, Carrier M, Trnkus A, Porco JA, Minden M, Pelletier J. Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells. Leukemia Research. 34: 535-41. PMID 19726085 DOI: 10.1016/J.Leukres.2009.07.043  0.184
2016 Chu J, Galicia-Vázquez G, Cencic R, Mills JR, Katigbak A, Porco JA, Pelletier J. CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A. Cell Reports. PMID 27239032 DOI: 10.1016/J.Celrep.2016.05.005  0.183
1999 Deegan TL, Nitz TJ, Cebzanov D, Pufko DE, Porco JA. Parallel synthesis of 1,2,4-oxadiazoles using CDI activation. Bioorganic & Medicinal Chemistry Letters. 9: 209-12. PMID 10021930 DOI: 10.1016/S0960-894X(98)00712-4  0.179
2021 Skofler C, Kleinegger F, Krassnig S, Birkl-Toeglhofer AM, Singer G, Till H, Benesch M, Cencic R, Porco JA, Pelletier J, Castellani C, Raicht A, Izycka-Swieszewska E, Czapiewski P, Haybaeck J. Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma. Cells. 10. PMID 33540613 DOI: 10.3390/cells10020301  0.177
2012 Lin CJ, Nasr Z, Premsrirut PK, Porco JA, Hippo Y, Lowe SW, Pelletier J. Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis. Cell Reports. 1: 325-33. PMID 22573234 DOI: 10.1016/J.Celrep.2012.02.010  0.176
2013 Nasr Z, Dow LE, Paquet M, Chu J, Ravindar K, Somaiah R, Deslongchamps P, Porco JA, Lowe SW, Pelletier J. Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia. Bmc Pharmacology & Toxicology. 14: 58. PMID 24219888 DOI: 10.1186/2050-6511-14-58  0.174
1999 Hu Y, Baudart S, Porco JA. Parallel Synthesis of 1,2,3-Thiadiazoles Employing a "Catch and Release" Strategy. The Journal of Organic Chemistry. 64: 1049-1051. PMID 11674188 DOI: 10.1021/jo981874v  0.172
2009 Cencic R, Carrier M, Galicia-Vázquez G, Bordeleau ME, Sukarieh R, Bourdeau A, Brem B, Teodoro JG, Greger H, Tremblay ML, Porco JA, Pelletier J. Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol. Plos One. 4: e5223. PMID 19401772 DOI: 10.1371/Journal.Pone.0005223  0.171
2021 Shen L, Pugsley L, Cencic R, Wang H, Robert F, Naineni SK, Sahni A, Morin G, Zhang W, Nijnik A, Porco JA, Langlais D, Huang S, Pelletier J. A forward genetic screen identifies modifiers of rocaglate responsiveness. Scientific Reports. 11: 18516. PMID 34531456 DOI: 10.1038/s41598-021-97765-8  0.17
2006 Zaarur N, Gabai VL, Porco JA, Calderwood S, Sherman MY. Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Research. 66: 1783-91. PMID 16452239 DOI: 10.1158/0008-5472.CAN-05-3692  0.169
2010 Roman W, Cencic R, Huang X, Porco J, Pelletier J, Shustik C, Sebag M. Inhibiting Translation as a Novel Strategy to Target Multiple Myeloma Blood. 116: 2995-2995. DOI: 10.1182/Blood.V116.21.2995.2995  0.169
2017 Yueh H, Gao Q, Porco JA, Beeler AB. A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues. Bioorganic & Medicinal Chemistry. PMID 28666859 DOI: 10.1016/j.bmc.2017.06.010  0.167
2013 Jin C, Rajabi H, Rodrigo CM, Porco JA, Kufe D. Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein. Oncogene. 32: 2179-88. PMID 22689062 DOI: 10.1038/onc.2012.236  0.165
2008 Cong H, Ledbetter D, Rowe GT, Caradonna JP, Porco JA. Electron transfer-initiated Diels-Alder cycloadditions of 2'-hydroxychalcones. Journal of the American Chemical Society. 130: 9214-5. PMID 18576647 DOI: 10.1021/Ja803094U  0.165
2018 Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, ... ... Porco JA, et al. METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis. Cell. PMID 30612740 DOI: 10.1016/J.Cell.2018.11.038  0.164
2018 Qin XJ, Feng MY, Liu H, Ni W, Rauwolf T, Porco JA, Yan H, He L, Liu HY. Eucalyptusdimers A-C, Dimeric Phloroglucinol-Phellandrene Meroterpenoids from Eucalyptus robusta. Organic Letters. PMID 30088934 DOI: 10.1021/acs.orglett.8b02259  0.16
2003 Harper JK, Arif AM, Ford EJ, Strobel GA, Porco JA, Tomer DP, Oneill KL, Heider EM, Grant DM. Pestacin: A 1,3-dihydro isobenzofuran from Pestalotiopsis microspora possessing antioxidant and antimycotic activities Tetrahedron. 59: 2471-2476. DOI: 10.1016/S0040-4020(03)00255-2  0.16
2013 Sadlish H, Galicia-Vazquez G, Paris CG, Aust T, Bhullar B, Chang L, Helliwell SB, Hoepfner D, Knapp B, Riedl R, Roggo S, Schuierer S, Studer C, Porco JA, Pelletier J, et al. Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex. Acs Chemical Biology. 8: 1519-27. PMID 23614532 DOI: 10.1021/Cb400158T  0.159
2015 Ishizawa J, Jacamo RO, Kojima K, Chachad D, Ruvolo V, Ruvolo P, Zang W, Tabe Y, Konopleva M, Devine W, Lindquist S, Porco JA, Whitesell L, Andreeff M. Inactivating Heat Shock Factor 1 (HSF1) in Acute Myeloid Leukemia By Pharmacological Inhibition of eIF4a: A Promising Therapeutic Approach Blood. 126: 2548-2548. DOI: 10.1182/Blood.V126.23.2548.2548  0.158
2000 Li C, Lobkovsky E, Porco JA. Total Synthesis of (±)-Torreyanic Acid Journal of the American Chemical Society. 122: 10484-10485. DOI: 10.1021/JA005552W  0.154
2011 Schatz JH, Oricchio E, Wolfe AL, Jiang M, Linkov I, Maragulia J, Shi W, Zhang Z, Rajasekhar VK, Pagano NC, Porco JA, Teruya-Feldstein J, Rosen N, Zelenetz AD, Pelletier J, et al. Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. The Journal of Experimental Medicine. 208: 1799-807. PMID 21859846 DOI: 10.1084/Jem.20110846  0.153
2009 Goodell JR, McMullen JP, Zaborenko N, Maloney JR, Ho CX, Jensen KF, Porco JA, Beeler AB. Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds. The Journal of Organic Chemistry. 74: 6169-80. PMID 20560568 DOI: 10.1021/Jo901073V  0.149
2012 Cong H, Porco JA. Chemical Synthesis of Complex Molecules Using Nanoparticle Catalysis. Acs Catalysis. 2: 65-70. PMID 22347681 DOI: 10.1021/cs200495s  0.148
2020 Liu H, He XZ, Feng MY, Yuan-Zeng, Rauwolf TJ, Shao LD, Ni W, Yan H, Porco JA, Hao XJ, Qin XJ, Liu HY. Acylphloroglucinols with acetylcholinesterase inhibitory effects from the fruits of Eucalyptus robusta. Bioorganic Chemistry. 103: 104127. PMID 32745755 DOI: 10.1016/j.bioorg.2020.104127  0.142
2007 Comer E, Rohan E, Deng L, Porco JA. An approach to skeletal diversity using functional group pairing of multifunctional scaffolds. Organic Letters. 9: 2123-6. PMID 17472394 DOI: 10.1021/ol070606t  0.142
2003 Lan P, Berta D, Porco JA, South MS, Parlow JJ. Polymer-assisted solution-phase (PASP) Suzuki couplings employing an anthracene-tagged palladium catalyst. The Journal of Organic Chemistry. 68: 9678-86. PMID 14656094 DOI: 10.1021/jo035129g  0.14
2019 Kong T, Xue Y, Cencic R, Zhu X, Monast A, Fu Z, Pilon V, Sangwan V, Guiot MC, Foulkes WD, Porco JA, Park M, Pelletier J, Huang S. eIF4A inhibitors suppress cell cycle feedback response and acquired resistance to CDK4/6 inhibition in cancer. Molecular Cancer Therapeutics. PMID 31395685 DOI: 10.1158/1535-7163.Mct-19-0162  0.139
2014 Carreira EM, Jacobsen MJ, Qi C, Qin T, Suzuki D, Porco JA. Synthesis of (±)-Sorbiterrin A Synfacts. 10: 456-456. DOI: 10.1055/S-0033-1341097  0.139
2014 Martin VI, Goodell JR, Ingham OJ, Porco JA, Beeler AB. Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes. The Journal of Organic Chemistry. 79: 3838-46. PMID 24697145 DOI: 10.1021/Jo500190B  0.133
2014 Wolfe AL, Singh K, Zhong Y, Drewe P, Rajasekhar VK, Sanghvi VR, Mavrakis KJ, Jiang M, Roderick JE, Van der Meulen J, Schatz JH, Rodrigo CM, Zhao C, Rondou P, de Stanchina E, ... ... Porco JA, et al. RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Nature. 513: 65-70. PMID 25079319 DOI: 10.1038/Nature13485  0.131
2016 Bhattacharya B, Chatterjee S, Devine WG, Kobzik L, Beeler AB, Porco JA, Kramnik I. Fine-tuning of macrophage activation using synthetic rocaglate derivatives. Scientific Reports. 6: 24409. PMID 27086720 DOI: 10.1038/Srep24409  0.129
2006 Helton ME, Maiti D, Zakharov LN, Rheingold AL, Porco JA, Karlin KD. A mu-eta2:eta2-disulfide dicopper(II) complex from reaction of S8 with a copper(I) precursor: reactivity of the bound disulfur moiety. Angewandte Chemie (International Ed. in English). 45: 1138-41. PMID 16385608 DOI: 10.1002/Anie.200503216  0.124
2010 Majumdar ID, Abdoly A, Cong H, Schwartzman J, Rossi L, Porco JA, Weber HC. M1984 Natural and Synthetic Flavonoids Possess Cytotoxic Activities Against Pancreatic Cancer Cells Gastroenterology. 138: S-452. DOI: 10.1016/S0016-5085(10)62093-8  0.119
2012 Yeo AT, Porco JA, Gilmore TD. Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis. Cancer Letters. 318: 53-60. PMID 22155272 DOI: 10.1016/J.Canlet.2011.11.035  0.119
2019 Steinberger J, Robert F, Hallé M, Williams DE, Cencic R, Sawhney N, Pelletier D, Williams P, Igarashi Y, Porco JA, Rodriguez AD, Kopp B, Bachmann B, Andersen RJ, Pelletier J. Tracing MYC Expression for Small Molecule Discovery. Cell Chemical Biology. PMID 30880156 DOI: 10.1016/J.Chembiol.2019.02.007  0.119
2016 Gandin V, Masvidal L, Hulea L, Gravel SP, Cargnello M, McLaughlan S, Cai Y, Balanathan P, Morita M, Rajakumar A, Furic L, Pollak M, Porco JA, St-Pierre J, Pelletier J, et al. nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs. Genome Research. PMID 26984228 DOI: 10.1101/Gr.197566.115  0.116
2007 Dandapani S, Duduta M, Panek JS, Porco JA. Skeletal diversity through radical cyclization of tetrahydropyridine scaffolds Organic Letters. 9: 3849-3852. PMID 17713919 DOI: 10.1021/Ol701722Z  0.115
2011 Pimparkar K, Yen B, Goodell J, Martin V, Lee WH, Porco J, Beeler A, Jensen K. Development of a photochemical microfluidics platform Journal of Flow Chemistry. 1: 53-55. DOI: 10.1556/Jfchem.2011.00006  0.109
2021 Jin C, Rajabi H, Rodrigo CM, Porco JA, Kufe D. Correction: Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein. Oncogene. 40: 3347. PMID 33850266 DOI: 10.1038/s41388-021-01727-3  0.104
2008 Williams AJ, Elyashberg ME, Blinov KA, Lankin DC, Martin GE, Reynolds WF, Porco JA, Singleton CA, Su S. Applying computer-assisted structure elucidation algorithms for the purpose of structure validation: revisiting the NMR assignments of hexacyclinol. Journal of Natural Products. 71: 581-8. PMID 18257535 DOI: 10.1021/np070557t  0.104
2013 Nasr Z, Robert F, Porco JA, Muller WJ, Pelletier J. eIF4F suppression in breast cancer affects maintenance and progression. Oncogene. 32: 861-71. PMID 22484424 DOI: 10.1038/Onc.2012.105  0.095
2007 Ong WW, Beeler AB, Kesavan S, Panek JS, Porco JA. Nucleophilic addition to N-phosphinylimines by rare-earth-metal triflate/trifluoroacetic anhydride activation Angewandte Chemie - International Edition. 46: 7470-7472. PMID 17722135 DOI: 10.1002/anie.200700694  0.092
2012 Porco JA. Recent developments in chemical diversity. Beilstein Journal of Organic Chemistry. 8: 827-8. PMID 23015830 DOI: 10.3762/bjoc.8.92  0.091
2020 Liu H, He XZ, Feng MY, Zeng Y, Rauwolf TJ, Shao LD, Ni W, Yan H, Porco JA, Hao XJ, Qin XJ, Liu HY. Corrigendum to "Acylphloroglucinols with acetylcholinesterase inhibitory effects from the fruits of Eucalyptus robusta". [Bioorg. Chem. 103 (2020) 104127]. Bioorganic Chemistry. 108: 104579. PMID 33493929 DOI: 10.1016/j.bioorg.2020.104579  0.088
2019 Gonçalves AC, Towers ER, Haq N, Porco JA, Pelletier J, Dawson SJ, Gale JE. Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity. Scientific Reports. 9: 12501. PMID 31467369 DOI: 10.1038/S41598-019-48393-W  0.082
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