David H. Sherman - Publications

Affiliations: 
Medicinal Chemistry University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
cryptophycin anticancer drugs
Website:
http://www.cancer.med.umich.edu/news/cope-scholar09.shtml

245 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Beyett TS, Fraley AE, Labudde E, Patra D, Coleman RC, Eguchi A, Glukhova A, Chen Q, Williams RM, Koch WJ, Sherman DH, Tesmer JJG. Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. Proceedings of the National Academy of Sciences of the United States of America. PMID 31337679 DOI: 10.1073/pnas.1818547116  0.68
2019 Kalkreuter E, CroweTipton JM, Lowell AN, Sherman DH, Williams GJ. Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units. Journal of the American Chemical Society. PMID 30676722 DOI: 10.1021/jacs.8b10521  0.4
2018 Kai A, Kato H, Sherman DH, Williams RM, Tsukamoto S. Isolation of a new indoxyl alkaloid, Amoenamide B, from NRRL 35600: biosynthetic implications and correction of the structure of Speramide B. Tetrahedron Letters. 50: 4236-4240. PMID 30765898 DOI: 10.1016/j.tetlet.2018.10.034  0.68
2018 Skiba MA, Bivins MM, Schultz JR, Bernard SM, Fiers WD, Dan Q, Kulkarni S, Wipf P, Gerwick WH, Sherman DH, Aldrich CC, Smith JL. Structural Basis of Polyketide Synthase O-Methylation. Acs Chemical Biology. PMID 30489068 DOI: 10.1021/acschembio.8b00687  0.6
2018 Hagan AK, Plotnick YM, Dingle RE, Mendel ZI, Cendrowski SR, Sherman DH, Tripathi A, Hanna PC. Petrobactin Protects against Oxidative Stress and Enhances Sporulation Efficiency in Bacillus anthracis Sterne. Mbio. 9. PMID 30401780 DOI: 10.1128/mBio.02079-18  0.32
2018 Newmister SA, Romminger S, Schmidt JJ, Williams RM, Smith JL, Berlinck RGS, Sherman DH. Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway. Organic & Biomolecular Chemistry. PMID 30141817 DOI: 10.1039/c8ob01565a  0.68
2018 McDonnell KJ, Chemler JA, Bartels PL, O'Brien E, Marvin ML, Ortega J, Stern RH, Raskin L, Li GM, Sherman DH, Barton JK, Gruber SB. A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S] cluster. Nature Chemistry. PMID 29915346 DOI: 10.1038/s41557-018-0068-x  0.64
2018 Slocum ST, Lowell AN, Tripathi AN, Shende VV, Smith JL, Sherman DH. Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway. Methods in Enzymology. 604: 207-236. PMID 29779653 DOI: 10.1016/bs.mie.2018.01.034  0.6
2018 Sherman DH, Tripathi A, Park SR, Sikkema A, Cho HJ, Wu J, Lee B, Xi C, Smith JL. A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity by the Cahuitamycin Starter Unit Activating Enzyme CahJ. Chembiochem : a European Journal of Chemical Biology. PMID 29742306 DOI: 10.1002/cbic.201800233  0.6
2018 Skiba MA, Sikkema AP, Moss NA, Lowell AN, Su M, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module. Acs Chemical Biology. PMID 29701944 DOI: 10.1021/acschembio.8b00252  0.6
2018 Klas KR, Kato H, Frisvad JC, Yu F, Newmister SA, Fraley AE, Sherman DH, Tsukamoto S, Williams RM. Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi. Natural Product Reports. PMID 29632911 DOI: 10.1039/c7np00042a  0.68
2018 Newmister SA, Li S, Garcia-Borràs M, Sanders JN, Yang S, Lowell AN, Yu F, Smith JL, Williams RM, Houk KN, Sherman DH. Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis. Nature Chemical Biology. PMID 29531360 DOI: 10.1038/s41589-018-0003-x  0.68
2017 Sugimoto K, Sadahiro Y, Kagiyama I, Kato H, Sherman DH, Williams RM, Tsukamoto S. Isolation of amoenamide A and five antipodal prenylated alkaloids fromNRRL 35600. Tetrahedron Letters. 58: 2797-2800. PMID 29622844 DOI: 10.1016/j.tetlet.2017.05.057  0.68
2017 Gilbert MM, DeMars MD, Yang S, Grandner JM, Wang S, Wang H, Narayan ARH, Sherman DH, Houk KN, Montgomery J. Synthesis of Diverse 11- and 12-Membered Macrolactones from a Common Linear Substrate Using a Single Biocatalyst. Acs Central Science. 3: 1304-1310. PMID 29296671 DOI: 10.1021/acscentsci.7b00450  0.68
2017 Kato H, Nakahara T, Sugimoto K, Matsuo K, Kagiyama I, Frisvad JC, Sherman DH, Williams RM, Tsukamoto S. Correction to "Isolation of Notoamide S and Enantiomeric 6-epi-Stephacidin A from the Terrestrial Fungus Aspergillus amoenus: Biogenetic Implications". Organic Letters. PMID 29235872 DOI: 10.1021/acs.orglett.7b03781  0.68
2017 Mike LA, Tripathi A, Blankenship CM, Saluk A, Schultz PJ, Tamayo-Castillo G, Sherman DH, Mobley HLT. Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments. Chemical Communications (Cambridge, England). PMID 29139494 DOI: 10.1039/c7cc07732g  0.32
2017 Skiba MA, Sikkema AP, Moss NA, Tran CL, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL. A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit. Acs Chemical Biology. PMID 29096064 DOI: 10.1021/acschembio.7b00746  0.6
2017 Almutairi MM, Svetlov MS, Hansen DA, Khabibullina NF, Klepacki D, Kang HY, Sherman DH, Vázquez-Laslop N, Polikanov YS, Mankin AS. Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins. Nucleic Acids Research. 45: 9573-9582. PMID 28934499 DOI: 10.1093/nar/gkx673  0.36
2017 Hansen DA, Koch AA, Sherman DH. Identification of a thioesterase bottleneck in the pikromycin pathway through full-module processing of unnatural pentaketides. Journal of the American Chemical Society. PMID 28836772 DOI: 10.1021/jacs.7b06432  0.36
2017 Koch AA, Hansen DA, Shende VV, Furan LR, Houk KN, Jiménez-Osés G, Sherman DH. A single active site mutation in the pikromycin thioesterase generates a more effective macrocyclization catalyst. Journal of the American Chemical Society. PMID 28836768 DOI: 10.1021/jacs.7b06436  0.36
2017 Fraley AE, Garcia-Borràs M, Tripathi A, Khare D, Mercado-Marin EV, Tran H, Dan Q, Webb G, Watts K, Crews P, Sarpong R, Williams RM, Smith JL, Houk KN, Sherman DH. Function and structure of MalA/MalA', iterative halogenases for late-stage C-H functionalization of indole alkaloids. Journal of the American Chemical Society. PMID 28777910 DOI: 10.1021/jacs.7b06773  0.68
2017 Paul S, Ludeña Y, Villena GK, Yu F, Sherman DH, Gutiérrez-Correa M. High-quality draft genome sequence of a biofilm forming lignocellulolytic Aspergillus niger strain ATCC 10864. Standards in Genomic Sciences. 12: 37. PMID 28725336 DOI: 10.1186/s40793-017-0254-2  0.4
2017 Lowell AN, DeMars MD, Slocum ST, Yu F, Anand K, Chemler JA, Korakavi N, Priessnitz JK, Park SR, Koch AA, Schultz PJ, Sherman DH. Chemoenzymatic total synthesis and structural diversification of tylactone-based macrolide antibiotics through late-stage polyketide assembly, tailoring, and C-H functionalization. Journal of the American Chemical Society. PMID 28525276 DOI: 10.1021/jacs.7b02875  0.64
2017 Tietz DR, Podust LM, Sherman DH, Pochapsky TC. Solution conformations and dynamics of substrate-bound cytochrome P450 MycG. Biochemistry. PMID 28488849 DOI: 10.1021/acs.biochem.7b00291  0.6
2017 Paul S, Zhang A, Ludeña Y, Villena GK, Yu F, Sherman DH, Gutiérrez-Correa M. Insights from the genome of a high alkaline cellulase producing Aspergillus fumigatus strain obtained from Peruvian Amazon rainforest. Journal of Biotechnology. PMID 28412514 DOI: 10.1016/j.jbiotec.2017.04.010  0.4
2017 Li Z, Du L, Zhang W, Zhang X, Jiang Y, Liu K, Men P, Xu H, Fortman JL, Sherman DH, Yu B, Gao S, Li S. Complete Elucidation of the Late Steps of Bafilomycin Biosynthesis in Streptomyces lohii. The Journal of Biological Chemistry. PMID 28292933 DOI: 10.1074/jbc.M116.751255  0.84
2017 Li S, Lowell AN, Newmister SA, Yu F, Williams RM, Sherman DH. Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids. Nature Chemical Biology. PMID 28288107 DOI: 10.1038/nchembio.2327  0.68
2017 Koryakina I, Kasey C, McArthur JB, Lowell AN, Chemler JA, Li S, Hansen DA, Sherman DH, Williams GJ. Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering. Acs Chemical Biology. 12: 114-123. PMID 28103677 DOI: 10.1021/acschembio.6b00732  0.68
2016 Zhang X, Li Z, Du L, Chlipala GE, Lopez PC, Zhang W, Sherman DH, Li S. Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis. Tetrahedron Letters. 57: 5919-5923. PMID 28989201 DOI: 10.1016/j.tetlet.2016.11.080  0.84
2016 Fiers WD, Dodge GJ, Sherman DH, Smith JL, Aldrich CC. Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis. Journal of the American Chemical Society. 138: 16024-16036. PMID 27960309 DOI: 10.1021/jacs.6b09748  0.6
2016 Chatterjee P, Davis E, Yu F, James S, Wildschutte JH, Wiegmann DD, Sherman DH, McKay RM, LiPuma JJ, Wildschutte H. Environmental pseudomonads inhibit cystic fibrosis patient-derived Pseudomonas aeruginosa. Applied and Environmental Microbiology. PMID 27881418 DOI: 10.1128/AEM.02701-16  0.4
2016 Skiba MA, Sikkema AP, Fiers WD, Gerwick WH, Sherman DH, Aldrich CC, Smith JL. Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase. Acs Chemical Biology. PMID 27723289 DOI: 10.1021/acschembio.6b00759  0.6
2016 Maloney FP, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proceedings of the National Academy of Sciences of the United States of America. PMID 27573844 DOI: 10.1073/pnas.1607210113  0.6
2016 Newmister SA, Gober CM, Romminger S, Yu F, Tripathi A, Parra LL, Williams RM, Berlinck RG, Joullié MM, Sherman DH. OxaD, a versatile indolic nitrone synthase from the marine-derived fungus Penicillium oxalicum F30. Journal of the American Chemical Society. PMID 27505044 DOI: 10.1021/jacs.6b04915  1
2016 DeMars MD, Sheng F, Park SR, Lowell AN, Podust LM, Sherman DH. Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway. Acs Chemical Biology. PMID 27420774 DOI: 10.1021/acschembio.6b00479  0.6
2016 Tripathi A, Choi SS, Sherman DH, Kim ES. Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412. Journal of Industrial Microbiology & Biotechnology. PMID 27277081 DOI: 10.1007/s10295-016-1790-2  1
2016 Park SR, Tripathi A, Wu J, Schultz PJ, Yim I, McQuade TJ, Yu F, Arevang CJ, Mensah AY, Tamayo-Castillo G, Xi C, Sherman DH. Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway. Nature Communications. 7: 10710. PMID 26880271 DOI: 10.1038/ncomms10710  1
2016 Bertin MJ, Vulpanovici A, Monroe EA, Korobeynikov A, Sherman DH, Gerwick L, Gerwick WH. The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide. Chembiochem : a European Journal of Chemical Biology. 17: 164-73. PMID 26769357 DOI: 10.1002/cbic.201500467  1
2016 Kleigrewe K, Gerwick L, Sherman DH, Gerwick WH. Unique marine derived cyanobacterial biosynthetic genes for chemical diversity. Natural Product Reports. PMID 26758451 DOI: 10.1039/c5np00097a  0.6
2015 Kagiyama I, Kato H, Nehira T, Frisvad JC, Sherman DH, Williams RM, Tsukamoto S. Taichunamides: Prenylated Indole Alkaloids from Aspergillus taichungensis (IBT 19404). Angewandte Chemie (International Ed. in English). PMID 26644336 DOI: 10.1002/anie.201509462  0.68
2015 Li S, Lowell AN, Yu F, Raveh A, Newmister SA, Bair N, Schaub JM, Williams RM, Sherman DH. Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade. Journal of the American Chemical Society. PMID 26629885 DOI: 10.1021/jacs.5b10136  1
2015 Sidhu A, Miller JR, Tripathi A, Garshott DM, Brownell AL, Chiego DJ, Arevang C, Zeng Q, Jackson LC, Bechler SA, Callaghan MU, Yoo GH, Sethi S, Lin HS, Callaghan JH, ... ... Sherman DH, et al. Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis. Acs Medicinal Chemistry Letters. 6: 1122-1127. PMID 26617965 DOI: 10.1021/acsmedchemlett.5b00133  1
2015 Khare D, Hale WA, Tripathi A, Gu L, Sherman DH, Gerwick WH, Håkansson K, Smith JL. Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase. Structure (London, England : 1993). PMID 26526850 DOI: 10.1016/j.str.2015.09.013  0.6
2015 Klas K, Tsukamoto S, Sherman DH, Williams RM. Natural Diels-Alderases: Elusive and Irresistable. The Journal of Organic Chemistry. PMID 26495876 DOI: 10.1021/acs.joc.5b01951  1
2015 Cheng KC, Cao S, Raveh A, MacArthur R, Dranchak P, Chlipala G, Okoneski MT, Guha R, Eastman RT, Yuan J, Schultz PJ, Su XZ, Tamayo-Castillo G, Matainaho T, Clardy J, ... Sherman DH, et al. Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts. Journal of Natural Products. PMID 26465675 DOI: 10.1021/acs.jnatprod.5b00489  1
2015 Almutairi MM, Park SR, Rose S, Hansen DA, Vázquez-Laslop N, Douthwaite S, Sherman DH, Mankin AS. Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides. Proceedings of the National Academy of Sciences of the United States of America. PMID 26438831 DOI: 10.1073/pnas.1512090112  1
2015 Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Sherman DH, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/nchembio.1890  0.36
2015 Chemler JA, Tripathi A, Hansen DA, O'Neil-Johnson M, Williams RB, Starks C, Park SR, Sherman DH. Evolution of Efficient Modular Polyketide Synthases by Homeologous Recombination. Journal of the American Chemical Society. PMID 26230368 DOI: 10.1021/jacs.5b04842  1
2015 Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick WH. Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows. Plos One. 10: e0133297. PMID 26222584 DOI: 10.1371/journal.pone.0133297  1
2015 Narayan AR, Jiménez-Osés G, Liu P, Negretti S, Zhao W, Gilbert MM, Ramabhadran RO, Yang YF, Furan LR, Li Z, Podust LM, Montgomery J, Houk KN, Sherman DH. Enzymatic hydroxylation of an unactivated methylene C-H bond guided by molecular dynamics simulations. Nature Chemistry. 7: 653-60. PMID 26201742 DOI: 10.1038/nchem.2285  1
2015 Sherman DH, Tsukamoto S, Williams RM. ORGANIC SYNTHESIS. Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence". Science (New York, N.Y.). 349: 149. PMID 26160938 DOI: 10.1126/science.aaa9349  1
2015 Kleigrewe K, Almaliti J, Tian IY, Kinnel RB, Korobeynikov A, Monroe EA, Duggan BM, Di Marzo V, Sherman DH, Dorrestein PC, Gerwick L, Gerwick WH. Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria. Journal of Natural Products. PMID 26149623 DOI: 10.1021/acs.jnatprod.5b00301  1
2015 Lowell AN, Santoro N, Swaney SM, McQuade TJ, Schultz PJ, Larsen MJ, Sherman DH. Microscale Adaptation of In Vitro Transcription/Translation for High-Throughput Screening of Natural Product Extract Libraries. Chemical Biology & Drug Design. PMID 26147927 DOI: 10.1111/cbdd.12614  1
2015 Schofield MM, Jain S, Porat D, Dick GJ, Sherman DH. Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743. Environmental Microbiology. PMID 26013440 DOI: 10.1111/1462-2920.12908  1
2015 Smith JL, Skiniotis G, Sherman DH. Architecture of the polyketide synthase module: surprises from electron cryo-microscopy. Current Opinion in Structural Biology. 31: 9-19. PMID 25791608 DOI: 10.1016/j.sbi.2015.02.014  0.6
2015 Kato H, Nakahara T, Yamaguchi M, Kagiyama I, Finefield JM, Sunderhaus JD, Sherman DH, Williams RM, Tsukamoto S. Bioconversion of 6-epi-Notoamide T Produces Metabolites of Unprecedented Structures in a Marine-derived Aspergillus sp. Tetrahedron Letters. 56: 247-251. PMID 25767298 DOI: 10.1016/j.tetlet.2014.11.083  1
2015 Hansen DA, Koch AA, Sherman DH. Substrate controlled divergence in polyketide synthase catalysis. Journal of the American Chemical Society. 137: 3735-8. PMID 25730816 DOI: 10.1021/ja511743n  1
2015 Bernard SM, Akey DL, Tripathi A, Park SR, Konwerski JR, Anzai Y, Li S, Kato F, Sherman DH, Smith JL. Structural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugar O-methyltransferases. Acs Chemical Biology. 10: 1340-51. PMID 25692963 DOI: 10.1021/cb5009348  1
2015 Kato H, Nakahara T, Sugimoto K, Matsuo K, Kagiyama I, Frisvad JC, Sherman DH, Williams RM, Tsukamoto S. Isolation of notoamide S and enantiomeric 6-epi-stephacidin A from the fungus Aspergillus amoenus: biogenetic implications. Organic Letters. 17: 700-3. PMID 25615822 DOI: 10.1021/ol5037198  1
2015 Delekta PC, Raveh A, Larsen MJ, Schultz PJ, Tamayo-Castillo G, Sherman DH, Miller DJ. The combined use of alphavirus replicons and pseudoinfectious particles for the discovery of antivirals derived from natural products. Journal of Biomolecular Screening. 20: 673-80. PMID 25550354 DOI: 10.1177/1087057114564868  0.4
2015 Cruz PG, Fribley AM, Miller JR, Larsen MJ, Schultz PJ, Jacob RT, Tamayo-Castillo G, Kaufman RJ, Sherman DH. Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts Acs Medicinal Chemistry Letters. 6: 877-881. DOI: 10.1021/acsmedchemlett.5b00127  1
2015 Shinde PB, Oh HS, Choi H, Rathwell K, Ban YH, Kim EJ, Yang I, Lee DG, Sherman DH, Kang HY, Yoon YJ. Chemoenzymatic Synthesis of Glycosylated Macrolactam Analogues of the Macrolide Antibiotic YC-17 Advanced Synthesis and Catalysis. 357: 2697-2711. DOI: 10.1002/adsc.201500250  1
2014 Vargas-Asensio G, Pinto-Tomas A, Rivera B, Hernandez M, Hernandez C, Soto-Montero S, Murillo C, Sherman DH, Tamayo-Castillo G. Uncovering the cultivable microbial diversity of costa rican beetles and its ability to break down plant cell wall components. Plos One. 9: e113303. PMID 25411842 DOI: 10.1371/journal.pone.0113303  1
2014 Raveh A, Schultz PJ, Aschermann L, Carpenter C, Tamayo-Castillo G, Cao S, Clardy J, Neubig RR, Sherman DH, Sjögren B. Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts. Molecular Pharmacology. 86: 406-16. PMID 25086086 DOI: 10.1124/mol.114.092403  1
2014 Whicher JR, Dutta S, Hansen DA, Hale WA, Chemler JA, Dosey AM, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature. 510: 560-4. PMID 24965656 DOI: 10.1038/nature13409  1
2014 Dutta S, Whicher JR, Hansen DA, Hale WA, Chemler JA, Congdon GR, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Structure of a modular polyketide synthase. Nature. 510: 512-7. PMID 24965652 DOI: 10.1038/nature13423  1
2014 Newmister SA, Sherman DH. Crystal structures of acyl carrier protein in complex with two catalytic partners show a dynamic role in cellular metabolism. Chembiochem : a European Journal of Chemical Biology. 15: 1079-81. PMID 24771327 DOI: 10.1002/cbic.201402095  1
2014 Walter GM, Raveh A, Mok SA, McQuade TJ, Arevang CJ, Schultz PJ, Smith MC, Asare S, Cruz PG, Wisen S, Matainaho T, Sherman DH, Gestwicki JE. High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity. Chemical Biology & Drug Design. 83: 440-9. PMID 24636344 DOI: 10.1111/cbdd.12259  1
2014 Negretti S, Narayan AR, Chiou KC, Kells PM, Stachowski JL, Hansen DA, Podust LM, Montgomery J, Sherman DH. Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation. Journal of the American Chemical Society. 136: 4901-4. PMID 24627965 DOI: 10.1021/ja5016052  1
2014 Zhang W, Liu Y, Yan J, Cao S, Bai F, Yang Y, Huang S, Yao L, Anzai Y, Kato F, Podust LM, Sherman DH, Li S. New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners. Journal of the American Chemical Society. 136: 3640-6. PMID 24521145 DOI: 10.1021/ja4130302  1
2014 Coates RC, Podell S, Korobeynikov A, Lapidus A, Pevzner P, Sherman DH, Allen EE, Gerwick L, Gerwick WH. Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways. Plos One. 9: e85140. PMID 24475038 DOI: 10.1371/journal.pone.0085140  1
2014 Larsen MJ, Larsen SD, Fribley A, Grembecka J, Homan K, Mapp A, Haak A, Nikolovska-Coleska Z, Stuckey JA, Sun D, Sherman DH. The role of HTS in drug discovery at the University of Michigan. Combinatorial Chemistry & High Throughput Screening. 17: 210-30. PMID 24409957 DOI: 10.2174/1386207317666140109121546  1
2014 Tripathi A, Schofield MM, Chlipala GE, Schultz PJ, Yim I, Newmister SA, Nusca TD, Scaglione JB, Hanna PC, Tamayo-Castillo G, Sherman DH. Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis. Journal of the American Chemical Society. 136: 1579-86. PMID 24401083 DOI: 10.1021/ja4115924  1
2013 Raveh A, Delekta PC, Dobry CJ, Peng W, Schultz PJ, Blakely PK, Tai AW, Matainaho T, Irani DN, Sherman DH, Miller DJ. Discovery of potent broad spectrum antivirals derived from marine actinobacteria. Plos One. 8: e82318. PMID 24349254 DOI: 10.1371/journal.pone.0082318  1
2013 Whicher JR, Smaga SS, Hansen DA, Brown WC, Gerwick WH, Sherman DH, Smith JL. Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis. Chemistry & Biology. 20: 1340-51. PMID 24183970 DOI: 10.1016/j.chembiol.2013.09.015  1
2013 Hansen DA, Rath CM, Eisman EB, Narayan AR, Kittendorf JD, Mortison JD, Yoon YJ, Sherman DH. Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin. Journal of the American Chemical Society. 135: 11232-8. PMID 23866020 DOI: 10.1021/ja404134f  1
2013 Schofield MM, Sherman DH. Meta-omic characterization of prokaryotic gene clusters for natural product biosynthesis. Current Opinion in Biotechnology. 24: 1151-8. PMID 23731715 DOI: 10.1016/j.copbio.2013.05.001  1
2013 Zhang W, Fortman JL, Carlson JC, Yan J, Liu Y, Bai F, Guan W, Jia J, Matainaho T, Sherman DH, Li S. Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii. Chembiochem : a European Journal of Chemical Biology. 14: 301-6. PMID 23362147 DOI: 10.1002/cbic.201200743  1
2013 Narayan AR, Sherman DH. Chemistry. Re-engineering nature's catalysts. Science (New York, N.Y.). 339: 283-4. PMID 23329039 DOI: 10.1126/science.1233324  1
2013 Sunderhaus JD, McAfoos TJ, Finefield JM, Kato H, Li S, Tsukamoto S, Sherman DH, Williams RM. Synthesis and bioconversions of notoamide T: a biosynthetic precursor to stephacidin A and notoamide B. Organic Letters. 15: 22-5. PMID 23249380 DOI: 10.1021/ol302901p  1
2012 Li S, Anand K, Tran H, Yu F, Finefield JM, Sunderhaus JD, McAfoos TJ, Tsukamoto S, Williams RM, Sherman DH. Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways. Medchemcomm. 3: 987-996. PMID 23213353 DOI: 10.1039/C2MD20029E  1
2012 Kim EJ, Lee JH, Choi H, Pereira AR, Ban YH, Yoo YJ, Kim E, Park JW, Sherman DH, Gerwick WH, Yoon YJ. Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product. Organic Letters. 14: 5824-7. PMID 23148802 DOI: 10.1021/ol302575h  1
2012 Majmudar CY, Højfeldt JW, Arevang CJ, Pomerantz WC, Gagnon JK, Schultz PJ, Cesa LC, Doss CH, Rowe SP, Vásquez V, Tamayo-Castillo G, Cierpicki T, Brooks CL, Sherman DH, Mapp AK. Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300. Angewandte Chemie (International Ed. in English). 51: 11258-62. PMID 23042634 DOI: 10.1002/anie.201206815  1
2012 McCarthy JG, Eisman EB, Kulkarni S, Gerwick L, Gerwick WH, Wipf P, Sherman DH, Smith JL. Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. Acs Chemical Biology. 7: 1994-2003. PMID 22991895 DOI: 10.1021/cb300385m  1
2012 Li S, Tietz DR, Rutaganira FU, Kells PM, Anzai Y, Kato F, Pochapsky TC, Sherman DH, Podust LM. Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions. The Journal of Biological Chemistry. 287: 37880-90. PMID 22952225 DOI: 10.1074/jbc.M112.410340  1
2012 Podust LM, Sherman DH. Diversity of P450 enzymes in the biosynthesis of natural products. Natural Product Reports. 29: 1251-66. PMID 22820933 DOI: 10.1039/c2np20020a  1
2012 Shareef AR, Sherman DH, Montgomery J. Nickel-Catalyzed Regiodivergent Approach to Macrolide Motifs. Chemical Science (Royal Society of Chemistry : 2010). 3: 892-895. PMID 22737401 DOI: 10.1039/C2SC00866A  1
2012 Kim D, Nah JH, Choi SS, Shin HS, Sherman DH, Kim ES. Biological activities of an engineered tautomycetin analogue via disruption of tmcR-encoding hydroxylase in Streptomyces sp. CK4412. Journal of Industrial Microbiology & Biotechnology. 39: 1563-8. PMID 22733296 DOI: 10.1007/s10295-012-1157-2  1
2012 Jacob RT, Larsen MJ, Larsen SD, Kirchhoff PD, Sherman DH, Neubig RR. MScreen: an integrated compound management and high-throughput screening data storage and analysis system. Journal of Biomolecular Screening. 17: 1080-7. PMID 22706349 DOI: 10.1177/1087057112450186  1
2012 Bolduc KL, Larsen SD, Sherman DH. Efficient, divergent synthesis of cryptophycin unit A analogues. Chemical Communications (Cambridge, England). PMID 22617820 DOI: 10.1039/c2cc32417b  1
2012 Finefield JM, Sherman DH, Kreitman M, Williams RM. Enantiomeric natural products: occurrence and biogenesis. Angewandte Chemie (International Ed. in English). 51: 4802-36. PMID 22555867 DOI: 10.1002/anie.201107204  1
2012 Anzai Y, Tsukada S, Sakai A, Masuda R, Harada C, Domeki A, Li S, Kinoshita K, Sherman DH, Kato F. Function of cytochrome P450 enzymes MycCI and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicin. Antimicrobial Agents and Chemotherapy. 56: 3648-56. PMID 22547618 DOI: 10.1128/AAC.06063-11  1
2012 Finefield JM, Frisvad JC, Sherman DH, Williams RM. Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids. Journal of Natural Products. 75: 812-33. PMID 22502590 DOI: 10.1021/np200954v  1
2012 Chemler JA, Buchholz TJ, Geders TW, Akey DL, Rath CM, Chlipala GE, Smith JL, Sherman DH. Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor. Journal of the American Chemical Society. 134: 7359-66. PMID 22480290 DOI: 10.1021/ja2112228  1
2012 Nusca TD, Kim Y, Maltseva N, Lee JY, Eschenfeldt W, Stols L, Schofield MM, Scaglione JB, Dixon SD, Oves-Costales D, Challis GL, Hanna PC, Pfleger BF, Joachimiak A, Sherman DH. Functional and structural analysis of the siderophore synthetase AsbB through reconstitution of the petrobactin biosynthetic pathway from Bacillus anthracis. The Journal of Biological Chemistry. 287: 16058-72. PMID 22408253 DOI: 10.1074/jbc.M112.359349  1
2012 Lee MJ, Kong D, Han K, Sherman DH, Bai L, Deng Z, Lin S, Kim ES. Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica. Applied Microbiology and Biotechnology. 95: 157-68. PMID 22382166 DOI: 10.1007/s00253-012-3955-x  1
2012 Li S, Finefield JM, Sunderhaus JD, McAfoos TJ, Williams RM, Sherman DH. Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids. Journal of the American Chemical Society. 134: 788-91. PMID 22188465 DOI: 10.1021/ja2093212  1
2012 Gehret JJ, Gu L, Geders TW, Brown WC, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Structure and activity of DmmA, a marine haloalkane dehalogenase. Protein Science : a Publication of the Protein Society. 21: 239-48. PMID 22124946 DOI: 10.1002/pro.2009  1
2012 Busche A, Gottstein D, Hein C, Ripin N, Pader I, Tufar P, Eisman EB, Gu L, Walsh CT, Sherman DH, Löhr F, Güntert P, Dötsch V. Characterization of molecular interactions between ACP and halogenase domains in the Curacin A polyketide synthase. Acs Chemical Biology. 7: 378-86. PMID 22103656 DOI: 10.1021/cb200352q  1
2012 Nah JH, Choi SS, Kim D, Shin HS, Sherman DH, Kim ES. Biosynthesis of an engineered tautomycetin analogue via disruption of tmcK-encoding terminal decarboxylase in Streptomyces CK4412 Process Biochemistry. 47: 1773-1778. DOI: 10.1016/j.procbio.2012.05.022  1
2012 Buchholz TJ, Kittendorf JD, Sherman DH. Modular Polyketide Synthases Natural Products in Chemical Biology. 163-187. DOI: 10.1002/9781118391815.ch7  1
2011 Finefield JM, Greshock TJ, Sherman DH, Tsukamoto S, Williams RM. Notoamide E: Biosynthetic incorporation into notoamides C and D in cultures of Aspergillus versicolor NRRL 35600. Tetrahedron Letters. 52: 1987-1989. PMID 22140279 DOI: 10.1016/j.tetlet.2011.02.078  1
2011 Cruz PG, Auld DS, Schultz PJ, Lovell S, Battaile KP, MacArthur R, Shen M, Tamayo-Castillo G, Inglese J, Sherman DH. Titration-based screening for evaluation of natural product extracts: identification of an aspulvinone family of luciferase inhibitors. Chemistry & Biology. 18: 1442-52. PMID 22118678 DOI: 10.1016/j.chembiol.2011.08.011  1
2011 Bonnett SA, Rath CM, Shareef AR, Joels JR, Chemler JA, Håkansson K, Reynolds K, Sherman DH. Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS. Chemistry & Biology. 18: 1075-81. PMID 21944746 DOI: 10.1016/j.chembiol.2011.07.016  1
2011 Akey DL, Li S, Konwerski JR, Confer LA, Bernard SM, Anzai Y, Kato F, Sherman DH, Smith JL. A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway. Journal of Molecular Biology. 413: 438-50. PMID 21884704 DOI: 10.1016/j.jmb.2011.08.040  1
2011 Rath CM, Janto B, Earl J, Ahmed A, Hu FZ, Hiller L, Dahlgren M, Kreft R, Yu F, Wolff JJ, Kweon HK, Christiansen MA, Håkansson K, Williams RM, Ehrlich GD, ... Sherman DH, et al. Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. Acs Chemical Biology. 6: 1244-56. PMID 21875091 DOI: 10.1021/cb200244t  1
2011 Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, ... ... Sherman DH, et al. Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response. Journal of Biomolecular Screening. 16: 825-35. PMID 21844328 DOI: 10.1177/1087057111414893  1
2011 Ding Y, Rath CM, Bolduc KL, Håkansson K, Sherman DH. Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module. Journal of the American Chemical Society. 133: 14492-5. PMID 21823639 DOI: 10.1021/ja204716f  1
2011 Sunderhaus JD, Sherman DH, Williams RM. Studies on the Biosynthesis of the Stephacidin and Notoamide Natural Products: A Stereochemical and Genetic Conundrum. Israel Journal of Chemistry. 51: 442-452. PMID 21818159 DOI: 10.1002/ijch.201100016  1
2011 Carlson JC, Li S, Gunatilleke SS, Anzai Y, Burr DA, Podust LM, Sherman DH. Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes. Nature Chemistry. 3: 628-33. PMID 21778983 DOI: 10.1038/nchem.1087  1
2011 Finefield JM, Kato H, Greshock TJ, Sherman DH, Tsukamoto S, Williams RM. Biosynthetic studies of the notoamides: isotopic synthesis of stephacidin A and incorporation into notoamide B and sclerotiamide. Organic Letters. 13: 3802-5. PMID 21714564 DOI: 10.1021/ol201284y  1
2011 Lee JY, Passalacqua KD, Hanna PC, Sherman DH. Regulation of petrobactin and bacillibactin biosynthesis in Bacillus anthracis under iron and oxygen variation. Plos One. 6: e20777. PMID 21673962 DOI: 10.1371/journal.pone.0020777  1
2011 Singh S, Chang A, Goff RD, Bingman CA, Grüschow S, Sherman DH, Phillips GN, Thorson JS. Structural characterization of the mitomycin 7-O-methyltransferase. Proteins. 79: 2181-8. PMID 21538548 DOI: 10.1002/prot.23040  1
2011 Finefield JM, Sherman DH, Tsukamoto S, Williams RM. Studies on the biosynthesis of the notoamides: synthesis of an isotopomer of 6-hydroxydeoxybrevianamide E and biosynthetic incorporation into notoamide J. The Journal of Organic Chemistry. 76: 5954-8. PMID 21504234 DOI: 10.1021/jo200218a  1
2011 Gu L, Eisman EB, Dutta S, Franzmann TM, Walter S, Gerwick WH, Skiniotis G, Sherman DH. Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect. Angewandte Chemie (International Ed. in English). 50: 2795-8. PMID 21387490 DOI: 10.1002/anie.201005280  1
2011 Gehret JJ, Gu L, Gerwick WH, Wipf P, Sherman DH, Smith JL. Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase. The Journal of Biological Chemistry. 286: 14445-54. PMID 21357626 DOI: 10.1074/jbc.M110.214635  1
2010 McAfoos TJ, Li S, Tsukamoto S, Sherman DH, Williams RM. STUDIES ON THE BIOSYNTHESIS OF THE STEPHACIDINS AND NOTOAMIDES. TOTAL SYNTHESIS OF NOTOAMIDE S. Heterocycles. 82: 461-472. PMID 21796227 DOI: 10.3987/COM-10-S(E)19  1
2010 Buchholz TJ, Rath CM, Lopanik NB, Gardner NP, Håkansson K, Sherman DH. Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase. Chemistry & Biology. 17: 1092-100. PMID 21035732 DOI: 10.1016/j.chembiol.2010.08.008  1
2010 Himpsl SD, Pearson MM, Arewång CJ, Nusca TD, Sherman DH, Mobley HL. Proteobactin and a yersiniabactin-related siderophore mediate iron acquisition in Proteus mirabilis. Molecular Microbiology. 78: 138-57. PMID 20923418 DOI: 10.1111/j.1365-2958.2010.07317.x  1
2010 Mortison JD, Sherman DH. Frontiers and opportunities in chemoenzymatic synthesis. The Journal of Organic Chemistry. 75: 7041-51. PMID 20882949 DOI: 10.1021/jo101124n  1
2010 Ding Y, de Wet JR, Cavalcoli J, Li S, Greshock TJ, Miller KA, Finefield JM, Sunderhaus JD, McAfoos TJ, Tsukamoto S, Williams RM, Sherman DH. Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp. Journal of the American Chemical Society. 132: 12733-40. PMID 20722388 DOI: 10.1021/ja1049302  1
2010 Khare D, Wang B, Gu L, Razelun J, Sherman DH, Gerwick WH, HÃ¥kansson K, Smith JL. Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 14099-104. PMID 20660778 DOI: 10.1073/pnas.1006738107  1
2010 Scaglione JB, Akey DL, Sullivan R, Kittendorf JD, Rath CM, Kim ES, Smith JL, Sherman DH. Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase. Angewandte Chemie (International Ed. in English). 49: 5726-30. PMID 20623733 DOI: 10.1002/anie.201000032  1
2010 Carlson PE, Dixon SD, Janes BK, Carr KA, Nusca TD, Anderson EC, Keene SE, Sherman DH, Hanna PC. Genetic analysis of petrobactin transport in Bacillus anthracis. Molecular Microbiology. 75: 900-9. PMID 20487286 DOI: 10.1111/j.1365-2958.2009.07025.x  1
2010 Jones AC, Monroe EA, Eisman EB, Gerwick L, Sherman DH, Gerwick WH. The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria. Natural Product Reports. 27: 1048-65. PMID 20442916 DOI: 10.1039/c000535e  1
2010 Tsukada S, Anzai Y, Li S, Kinoshita K, Sherman DH, Kato F. Gene targeting for O-methyltransferase genes, mycE and mycF, on the chromosome of Micromonospora griseorubida producing mycinamicin with a disruption cassette containing the bacteriophage phi C31 attB attachment site. Fems Microbiology Letters. 304: 148-56. PMID 20158522 DOI: 10.1111/j.1574-6968.2010.01899.x  1
2010 Akey DL, Razelun JR, Tehranisa J, Sherman DH, Gerwick WH, Smith JL. Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Structure (London, England : 1993). 18: 94-105. PMID 20152156 DOI: 10.1016/j.str.2009.10.018  1
2010 Carlson JC, Fortman JL, Anzai Y, Li S, Burr DA, Sherman DH. Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9. Chembiochem : a European Journal of Chemical Biology. 11: 564-72. PMID 20127927 DOI: 10.1002/cbic.200900658  1
2010 Ding Y, Sherman DH. The role of synthesis and biosynthetic logic Comprehensive Natural Products Ii: Chemistry and Biology. 2: 559-579.  1
2010 Rath CM, Scaglione JB, Kittendorf JD, Sherman DH. NRPS/PKS hybrid enzymes and their natural products Comprehensive Natural Products Ii: Chemistry and Biology. 1: 453-492.  1
2009 Carlson JC, Li S, Burr DA, Sherman DH. Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp. Journal of Natural Products. 72: 2076-9. PMID 19883065 DOI: 10.1021/np9005597  1
2009 Sherman DH. Biochemistry: Enzyme's black box cracked open. Nature. 461: 1068-9. PMID 19847256 DOI: 10.1038/4611068a  1
2009 Gu L, Wang B, Kulkarni A, Gehret JJ, Lloyd KR, Gerwick L, Gerwick WH, Wipf P, HÃ¥kansson K, Smith JL, Sherman DH. Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. Journal of the American Chemical Society. 131: 16033-5. PMID 19835378 DOI: 10.1021/ja9071578  1
2009 Li S, Chaulagain MR, Knauff AR, Podust LM, Montgomery J, Sherman DH. Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase. Proceedings of the National Academy of Sciences of the United States of America. 106: 18463-8. PMID 19833867 DOI: 10.1073/pnas.0907203106  1
2009 Mortison JD, Kittendorf JD, Sherman DH. Synthesis and biochemical analysis of complex chain-elongation intermediates for interrogation of molecular specificity in the erythromycin and pikromycin polyketide synthases. Journal of the American Chemical Society. 131: 15784-93. PMID 19810731 DOI: 10.1021/ja9060596  1
2009 Kim BG, Lee MJ, Seo J, Hwang YB, Lee MY, Han K, Sherman DH, Kim ES. Identification of functionally clustered nystatin-like biosynthetic genes in a rare actinomycetes, Pseudonocardia autotrophica. Journal of Industrial Microbiology & Biotechnology. 36: 1425-34. PMID 19697072 DOI: 10.1007/s10295-009-0629-5  1
2009 Li MH, Ung PM, Zajkowski J, Garneau-Tsodikova S, Sherman DH. Automated genome mining for natural products. Bmc Bioinformatics. 10: 185. PMID 19531248 DOI: 10.1186/1471-2105-10-185  1
2009 Gu L, Wang B, Kulkarni A, Geders TW, Grindberg RV, Gerwick L, HÃ¥kansson K, Wipf P, Smith JL, Gerwick WH, Sherman DH. Metamorphic enzyme assembly in polyketide diversification. Nature. 459: 731-5. PMID 19494914 DOI: 10.1038/nature07870  1
2009 Yan J, Gupta S, Sherman DH, Reynolds KA. Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains. Chembiochem : a European Journal of Chemical Biology. 10: 1537-43. PMID 19437523 DOI: 10.1002/cbic.200900098  1
2009 Hu PJ, Sherman DH. DANSing with Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 106: 7685-6. PMID 19416852 DOI: 10.1073/pnas.0903021106  1
2009 Li S, Anzai Y, Kinoshita K, Kato F, Sherman DH. Functional analysis of MycE and MycF, two O-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics. Chembiochem : a European Journal of Chemical Biology. 10: 1297-301. PMID 19415708 DOI: 10.1002/cbic.200900088  1
2009 Park SH, Choi SS, Kim YJ, Chang YK, Sherman DH, Kim ES. Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412. Journal of Industrial Microbiology & Biotechnology. 36: 993-8. PMID 19408025 DOI: 10.1007/s10295-009-0580-5  1
2009 Jones AC, Gu L, Sorrels CM, Sherman DH, Gerwick WH. New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Current Opinion in Chemical Biology. 13: 216-23. PMID 19307147 DOI: 10.1016/j.cbpa.2009.02.019  1
2009 Sharp K, Arthur KE, Gu L, Ross C, Harrison G, Gunasekera SP, Meickle T, Matthew S, Luesch H, Thacker RW, Sherman DH, Paul VJ. Phylogenetic and chemical diversity of three chemotypes of bloom-forming lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida. Applied and Environmental Microbiology. 75: 2879-88. PMID 19270119 DOI: 10.1128/AEM.02656-08  1
2009 Chamberland S, Grüschow S, Sherman DH, Williams RM. Synthesis of potential early-stage intermediates in the biosynthesis of FR900482 and mitomycin C. Organic Letters. 11: 791-4. PMID 19161340 DOI: 10.1021/ol802631c  1
2009 Buchholz TJ, Geders TW, Bartley FE, Reynolds KA, Smith JL, Sherman DH. Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. Acs Chemical Biology. 4: 41-52. PMID 19146481 DOI: 10.1021/cb8002607  1
2009 Li S, Ouellet H, Sherman DH, Podust LM. Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC from Streptomyces venezuelae. The Journal of Biological Chemistry. 284: 5723-30. PMID 19124459 DOI: 10.1074/jbc.M807592200  1
2009 Kittendorf JD, Sherman DH. The methymycin/pikromycin pathway: a model for metabolic diversity in natural product biosynthesis. Bioorganic & Medicinal Chemistry. 17: 2137-46. PMID 19027305 DOI: 10.1016/j.bmc.2008.10.082  1
2009 Park SH, Choi SS, Sherman DH, Kim ES. A global positive regulator afsR2 stimulates tautomycetin production via pathway-specific regulatory gene over-expression in Streptomyces sp. CK4412 Process Biochemistry. 44: 1298-1301. DOI: 10.1016/j.procbio.2009.08.005  1
2009 Auerbach T, Mermershtain I, Bashan A, Davidovich C, Rozenberg H, Sherman DH, Yonath A. Structural basis for the antibacterial activity of the 12-membered-ring mono-sugar macrolide methymycin Biotechnologia. 24-35.  1
2008 Lopanik NB, Shields JA, Buchholz TJ, Rath CM, Hothersall J, Haygood MG, Håkansson K, Thomas CM, Sherman DH. In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont. Chemistry & Biology. 15: 1175-86. PMID 19022178 DOI: 10.1016/j.chembiol.2008.09.013  1
2008 Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH. Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 17133-8. PMID 18955706 DOI: 10.1073/pnas.0808118105  1
2008 Ding Y, Greshock TJ, Miller KA, Sherman DH, Williams RM. Premalbrancheamide: synthesis, isotopic labeling, biosynthetic incorporation, and detection in cultures of Malbranchea aurantiaca. Organic Letters. 10: 4863-6. PMID 18844365 DOI: 10.1021/ol8019633  1
2008 Hur YA, Choi SS, Sherman DH, Kim ES. Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412. Microbiology (Reading, England). 154: 2912-9. PMID 18832298 DOI: 10.1099/mic.0.2008/018903-0  1
2008 Anzai Y, Li S, Chaulagain MR, Kinoshita K, Kato F, Montgomery J, Sherman DH. Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics. Chemistry & Biology. 15: 950-9. PMID 18804032 DOI: 10.1016/j.chembiol.2008.07.014  1
2008 Smith JL, Sherman DH. Biochemistry. An enzyme assembly line. Science (New York, N.Y.). 321: 1304-5. PMID 18772425 DOI: 10.1126/science.1163785  1
2008 Ding Y, Gruschow S, Greshock TJ, Finefield JM, Sherman DH, Williams RM. Detection of VM55599 and preparaherquamide from Aspergillus japonicus and Penicillium fellutanum: biosynthetic implications. Journal of Natural Products. 71: 1574-8. PMID 18754595 DOI: 10.1021/np800292n  1
2008 Jayapal KP, Philp RJ, Kok YJ, Yap MG, Sherman DH, Griffin TJ, Hu WS. Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. Plos One. 3: e2097. PMID 18461186 DOI: 10.1371/journal.pone.0002097  1
2008 Ding Y, Williams RM, Sherman DH. Molecular analysis of a 4-dimethylallyltryptophan synthase from Malbranchea aurantiaca. The Journal of Biological Chemistry. 283: 16068-76. PMID 18390548 DOI: 10.1074/jbc.M801991200  1
2008 Ding Y, Seufert WH, Beck ZQ, Sherman DH. Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity. Journal of the American Chemical Society. 130: 5492-8. PMID 18366166 DOI: 10.1021/ja710520q  1
2008 Miller KA, Welch TR, Greshock TJ, Ding Y, Sherman DH, Williams RM. Biomimetic total synthesis of malbrancheamide and malbrancheamide B. The Journal of Organic Chemistry. 73: 3116-9. PMID 18345688 DOI: 10.1021/jo800116y  1
2008 Lian W, Jayapal KP, Charaniya S, Mehra S, Glod F, Kyung YS, Sherman DH, Hu WS. Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2). Bmc Genomics. 9: 56. PMID 18230178 DOI: 10.1186/1471-2164-9-56  1
2008 Lee JY, Sherman DH, Hwang BK. In vitro antimicrobial and in vivo antioomycete activities of the novel antibiotic thiobutacin. Pest Management Science. 64: 172-7. PMID 18069650 DOI: 10.1002/ps.1494  1
2007 Gu L, Geders TW, Wang B, Gerwick WH, Håkansson K, Smith JL, Sherman DH. GNAT-like strategy for polyketide chain initiation. Science (New York, N.Y.). 318: 970-4. PMID 17991863 DOI: 10.1126/science.1148790  1
2007 Seufert W, Beck ZQ, Sherman DH. Enzymatic release and macrolactonization of cryptophycins from a safety-catch solid support. Angewandte Chemie (International Ed. in English). 46: 9298-300. PMID 17979172 DOI: 10.1002/anie.200703665  1
2007 Geders TW, Gu L, Mowers JC, Liu H, Gerwick WH, Håkansson K, Sherman DH, Smith JL. Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching. The Journal of Biological Chemistry. 282: 35954-63. PMID 17928301 DOI: 10.1074/jbc.M703921200  1
2007 Li S, Podust LM, Sherman DH. Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain. Journal of the American Chemical Society. 129: 12940-1. PMID 17915876 DOI: 10.1021/ja075842d  1
2007 Kittendorf JD, Beck BJ, Buchholz TJ, Seufert W, Sherman DH. Interrogating the molecular basis for multiple macrolactone ring formation by the pikromycin polyketide synthase. Chemistry & Biology. 14: 944-54. PMID 17719493 DOI: 10.1016/j.chembiol.2007.07.013  1
2007 Jayapal KP, Lian W, Glod F, Sherman DH, Hu WS. Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans. Bmc Genomics. 8: 229. PMID 17623098 DOI: 10.1186/1471-2164-8-229  1
2007 Beck ZQ, Burr DA, Sherman DH. Characterization of the beta-methylaspartate-alpha-decarboxylase (CrpG) from the cryptophycin biosynthetic pathway. Chembiochem : a European Journal of Chemical Biology. 8: 1373-5. PMID 17600793 DOI: 10.1002/cbic.200700162  1
2007 Kwon SJ, Lee MY, Ku B, Sherman DH, Dordick JS. High-throughput, microarray-based synthesis of natural product analogues via in vitro metabolic pathway construction. Acs Chemical Biology. 2: 419-25. PMID 17530734 DOI: 10.1021/cb700033s  1
2007 Sitachitta N, Lopanik NB, Mao Y, Sherman DH. Analysis of a parallel branch in the mitomycin biosynthetic pathway involving the mitN-encoded aziridine N-methyltransferase. The Journal of Biological Chemistry. 282: 20941-7. PMID 17507379 DOI: 10.1074/jbc.M702456200  1
2007 Grüschow S, Chang LC, Mao Y, Sherman DH. Hydroxyquinone O-methylation in mitomycin biosynthesis. Journal of the American Chemical Society. 129: 6470-6. PMID 17461583 DOI: 10.1021/ja0700193  1
2007 Grüschow S, Buchholz TJ, Seufert W, Dordick JS, Sherman DH. Substrate profile analysis and ACP-mediated acyl transfer in Streptomyces coelicolor Type III polyketide synthases. Chembiochem : a European Journal of Chemical Biology. 8: 863-8. PMID 17440908 DOI: 10.1002/cbic.200700026  1
2007 Passalacqua KD, Bergman NH, Lee JY, Sherman DH, Hanna PC. The global transcriptional responses of Bacillus anthracis Sterne (34F2) and a Delta sodA1 mutant to paraquat reveal metal ion homeostasis imbalances during endogenous superoxide stress. Journal of Bacteriology. 189: 3996-4013. PMID 17384197 DOI: 10.1128/JB.00185-07  1
2007 Choi SS, Hur YA, Sherman DH, Kim ES. Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412. Microbiology (Reading, England). 153: 1095-102. PMID 17379718 DOI: 10.1099/mic.0.2006/003194-0  1
2007 Pfleger BF, Lee JY, Somu RV, Aldrich CC, Hanna PC, Sherman DH. Characterization and analysis of early enzymes for petrobactin biosynthesis in Bacillus anthracis. Biochemistry. 46: 4147-57. PMID 17346033 DOI: 10.1021/bi6023995  1
2007 Li S, Grüschow S, Dordick JS, Sherman DH. Molecular analysis of the role of tyrosine 224 in the active site of Streptomyces coelicolor RppA, a bacterial type III polyketide synthase. The Journal of Biological Chemistry. 282: 12765-72. PMID 17331946 DOI: 10.1074/jbc.M700393200  1
2007 Liu H, Håkansson K, Lee JY, Sherman DH. Collision-activated dissociation, infrared multiphoton dissociation, and electron capture dissociation of the Bacillus anthracis siderophore petrobactin and its metal ion complexes. Journal of the American Society For Mass Spectrometry. 18: 842-9. PMID 17331739 DOI: 10.1016/j.jasms.2007.01.005  1
2007 Sudek S, Lopanik NB, Waggoner LE, Hildebrand M, Anderson C, Liu H, Patel A, Sherman DH, Haygood MG. Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina. Journal of Natural Products. 70: 67-74. PMID 17253852 DOI: 10.1021/np060361d  1
2007 Lee JY, Janes BK, Passalacqua KD, Pfleger BF, Bergman NH, Liu H, Håkansson K, Somu RV, Aldrich CC, Cendrowski S, Hanna PC, Sherman DH. Biosynthetic analysis of the petrobactin siderophore pathway from Bacillus anthracis. Journal of Bacteriology. 189: 1698-710. PMID 17189355 DOI: 10.1128/JB.01526-06  1
2007 Sherman DH, Cross SM, Kim S, Grandjean F, Long GJ, Miller MK. Characterization of the carbon and retained austenite distributions in martensitic medium carbon, high silicon steel Metallurgical and Materials Transactions a: Physical Metallurgy and Materials Science. 38: 1698-1711. DOI: 10.1007/s11661-007-9160-3  0.36
2007 Oh HS, Yun JS, Nah KH, Kang HY, Sherman DH. Synthesis of the tetraketide lactones from the pikromycin biosynthetic pathway European Journal of Organic Chemistry. 3369-3379. DOI: 10.1002/ejoc.200700254  1
2007 Sherman DH, Yang BJ, Catalina AV, Hattiangadi AA, Zhao P, Chuzhoy L, Johnson ML. Modeling of microstructure evolution of athermal transformation of lath martensite Materials Science Forum. 539: 4795-4800.  0.36
2006 Magarvey NA, Beck ZQ, Golakoti T, Ding Y, Huber U, Hemscheidt TK, Abelson D, Moore RE, Sherman DH. Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts. Acs Chemical Biology. 1: 766-79. PMID 17240975 DOI: 10.1021/cb6004307  1
2006 Venkatraman L, Salomon CE, Sherman DH, Fecik RA. Total synthesis of narbonolide and biotransformation to pikromycin. The Journal of Organic Chemistry. 71: 9853-6. PMID 17168607 DOI: 10.1021/jo062047u  1
2006 Sherman DH, Smith JL. Clearing the skies over modular polyketide synthases. Acs Chemical Biology. 1: 505-9. PMID 17168537 DOI: 10.1021/cb600376r  1
2006 Kittendorf JD, Sherman DH. Developing tools for engineering hybrid polyketide synthetic pathways. Current Opinion in Biotechnology. 17: 597-605. PMID 17046237 DOI: 10.1016/j.copbio.2006.09.005  1
2006 Giraldes JW, Akey DL, Kittendorf JD, Sherman DH, Smith JL, Fecik RA. Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels. Nature Chemical Biology. 2: 531-6. PMID 16969373 DOI: 10.1038/nchembio822  1
2006 Akey DL, Kittendorf JD, Giraldes JW, Fecik RA, Sherman DH, Smith JL. Structural basis for macrolactonization by the pikromycin thioesterase. Nature Chemical Biology. 2: 537-42. PMID 16969372 DOI: 10.1038/nchembio824  1
2006 Ku B, Cha J, Srinivasan A, Kwon SJ, Jeong JC, Sherman DH, Dordick JS. Chip-based polyketide biosynthesis and functionalization. Biotechnology Progress. 22: 1102-7. PMID 16889386 DOI: 10.1021/bp050413+  1
2006 Gu L, Jia J, Liu H, Håkansson K, Gerwick WH, Sherman DH. Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair. Journal of the American Chemical Society. 128: 9014-5. PMID 16834357 DOI: 10.1021/ja0626382  1
2006 Sherman DH, Li S, Yermalitskaya LV, Kim Y, Smith JA, Waterman MR, Podust LM. The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae. The Journal of Biological Chemistry. 281: 26289-97. PMID 16825192 DOI: 10.1074/jbc.M605478200  1
2006 Flatt PM, O'Connell SJ, McPhail KL, Zeller G, Willis CL, Sherman DH, Gerwick WH. Characterization of the initial enzymatic steps of barbamide biosynthesis. Journal of Natural Products. 69: 938-44. PMID 16792414 DOI: 10.1021/np050523q  1
2006 Lee SK, Park JW, Kim JW, Jung WS, Park SR, Choi CY, Kim ES, Kim BS, Ahn JS, Sherman DH, Yoon YJ. Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae. Journal of Natural Products. 69: 847-9. PMID 16724858 DOI: 10.1021/np060026p  1
2006 Jung WS, Lee SK, Hong JS, Park SR, Jeong SJ, Han AR, Sohng JK, Kim BG, Choi CY, Sherman DH, Yoon YJ. Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae. Applied Microbiology and Biotechnology. 72: 763-9. PMID 16493552 DOI: 10.1007/s00253-006-0318-5  1
2006 Nishizawa T, Grüschow S, Jayamaha DH, Nishizawa-Harada C, Sherman DH. Enzymatic assembly of the bis-indole core of rebeccamycin. Journal of the American Chemical Society. 128: 724-5. PMID 16417354 DOI: 10.1021/ja056749x  0.6
2006 Beck ZQ, Sherman DH. Development of an internally quenched fluorogenic substrate for kinetic analysis of thioesterases. Analytical Biochemistry. 349: 309-11. PMID 16360105 DOI: 10.1016/j.ab.2005.10.038  1
2006 Mehra S, Lian W, Jayapal KP, Charaniya SP, Sherman DH, Hu WS. A framework to analyze multiple time series data: a case study with Streptomyces coelicolor. Journal of Industrial Microbiology & Biotechnology. 33: 159-72. PMID 16217633 DOI: 10.1007/s10295-005-0034-7  1
2006 Sherman DH, Yang N, Miller MK, Grandjean F, Long GJ. 3D characterization of the carbon distribution in a medium carbon steel Ivnc and Ifes 2006 - Technical Digest - L9th International Vacuum Nanoelectronics Conference and 50th International Field Emission Symposium. 501-502. DOI: 10.1109/IVNC.2006.335296  0.36
2006 Grüschow S, Sherman DH. The Biosynthesis of Epoxides Aziridines and Epoxides in Organic Synthesis. 349-398. DOI: 10.1002/3527607862.ch10  1
2005 Beck ZQ, Aldrich CC, Magarvey NA, Georg GI, Sherman DH. Chemoenzymatic synthesis of cryptophycin/arenastatin natural products. Biochemistry. 44: 13457-66. PMID 16216069 DOI: 10.1021/bi051140u  1
2005 Venkatraman L, Aldrich CC, Sherman DH, Fecik RA. Formal total synthesis of the polyketide macrolactone narbonolide. The Journal of Organic Chemistry. 70: 7267-72. PMID 16122247 DOI: 10.1021/jo050924a  1
2005 Aldrich CC, Venkatraman L, Sherman DH, Fecik RA. Chemoenzymatic synthesis of the polyketide macrolactone 10-deoxymethynolide. Journal of the American Chemical Society. 127: 8910-1. PMID 15969542 DOI: 10.1021/ja0504340  1
2005 Aldrich CC, Beck BJ, Fecik RA, Sherman DH. Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates. Journal of the American Chemical Society. 127: 8441-52. PMID 15941278 DOI: 10.1021/ja042592h  1
2005 Fortman JL, Sherman DH. Utilizing the power of microbial genetics to bridge the gap between the promise and the application of marine natural products. Chembiochem : a European Journal of Chemical Biology. 6: 960-78. PMID 15880675 DOI: 10.1002/cbic.200400428  0.8
2005 Nishizawa T, Aldrich CC, Sherman DH. Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243. Journal of Bacteriology. 187: 2084-92. PMID 15743957 DOI: 10.1128/JB.187.6.2084-2092.2005  1
2005 Jeong JC, Srinivasan A, Grüschow S, Bach H, Sherman DH, Dordick JS. Exploiting the reaction flexibility of a type III polyketide synthase through in vitro pathway manipulation. Journal of the American Chemical Society. 127: 64-5. PMID 15631450 DOI: 10.1021/ja0441559  0.6
2004 Magarvey NA, Keller JM, Bernan V, Dworkin M, Sherman DH. Isolation and characterization of novel marine-derived actinomycete taxa rich in bioactive metabolites. Applied and Environmental Microbiology. 70: 7520-9. PMID 15574955 DOI: 10.1128/AEM.70.12.7520-7529.2004  1
2004 Hildebrand M, Waggoner LE, Liu H, Sudek S, Allen S, Anderson C, Sherman DH, Haygood M. bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina. Chemistry & Biology. 11: 1543-52. PMID 15556005 DOI: 10.1016/j.chembiol.2004.08.018  1
2004 Srinivasan A, Bach H, Sherman DH, Dordick JS. Bacterial P450-catalyzed polyketide hydroxylation on a microfluidic platform. Biotechnology and Bioengineering. 88: 528-35. PMID 15459906 DOI: 10.1002/bit.20285  1
2004 Chang Z, Sitachitta N, Rossi JV, Roberts MA, Flatt PM, Jia J, Sherman DH, Gerwick WH. Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 67: 1356-67. PMID 15332855 DOI: 10.1021/np0499261  1
2004 Kim BS, Sherman DH, Reynolds KA. An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases. Protein Engineering, Design & Selection : Peds. 17: 277-84. PMID 15067106 DOI: 10.1093/protein/gzh032  1
2004 Salomon CE, Magarvey NA, Sherman DH. Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery. Natural Product Reports. 21: 105-21. PMID 15039838 DOI: 10.1039/b301384g  1
2004 Podust LM, Bach H, Kim Y, Lamb DC, Arase M, Sherman DH, Kelly SL, Waterman MR. Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways. Protein Science : a Publication of the Protein Society. 13: 255-68. PMID 14691240 DOI: 10.1110/ps.03384804  0.6
2003 Beck BJ, Aldrich CC, Fecik RA, Reynolds KA, Sherman DH. Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase. Journal of the American Chemical Society. 125: 12551-7. PMID 14531700 DOI: 10.1021/ja034841s  1
2003 Beck BJ, Aldrich CC, Fecik RA, Reynolds KA, Sherman DH. Iterative chain elongation by a pikromycin monomodular polyketide synthase. Journal of the American Chemical Society. 125: 4682-3. PMID 12696866 DOI: 10.1021/ja029974c  1
2003 Podust LM, Kim Y, Arase M, Neely BA, Beck BJ, Bach H, Sherman DH, Lamb DC, Kelly SL, Waterman MR. The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systems. The Journal of Biological Chemistry. 278: 12214-21. PMID 12519772 DOI: 10.1074/jbc.M212210200  1
2002 Cropp TA, Kim BS, Beck BJ, Yoon YJ, Sherman DH, Reynolds KA. Recent developments in the production of novel polyketides by combinatorial biosynthesis. Biotechnology & Genetic Engineering Reviews. 19: 159-72. PMID 12520877  0.68
2002 Chang Z, Flatt P, Gerwick WH, Nguyen VA, Willis CL, Sherman DH. The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene. 296: 235-47. PMID 12383521  0.6
2002 Kim BS, Cropp TA, Beck BJ, Sherman DH, Reynolds KA. Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin. The Journal of Biological Chemistry. 277: 48028-34. PMID 12368286 DOI: 10.1074/jbc.M207770200  1
2002 Kim BS, Cropp TA, Florova G, Lindsay Y, Sherman DH, Reynolds KA. An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis. Biochemistry. 41: 10827-33. PMID 12196022 DOI: 10.1021/bi0256779  1
2002 Martin TW, Dauter Z, Devedjiev Y, Sheffield P, Jelen F, He M, Sherman DH, Otlewski J, Derewenda ZS, Derewenda U. Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein. Structure (London, England : 1993). 10: 933-42. PMID 12121648 DOI: 10.1016/S0969-2126(02)00778-5  1
2002 Beck BJ, Yoon YJ, Reynolds KA, Sherman DH. The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase. Chemistry & Biology. 9: 575-83. PMID 12031664 DOI: 10.1016/S1074-5521(02)00146-1  1
2002 Yoon YJ, Beck BJ, Kim BS, Kang HY, Reynolds KA, Sherman DH. Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chemistry & Biology. 9: 203-14. PMID 11880035 DOI: 10.1016/S1074-5521(02)00095-9  1
2001 Kyung YS, Sherman DH, Hu WS. Simultaneous analysis of spatio-temporal gene expression for cephamycin biosynthesis in Streptomyces clavuligerus. Biotechnology Progress. 17: 1000-7. PMID 11735432 DOI: 10.1021/bp0101076  0.68
2001 Zhang Q, Sherman DH. Isolation and structure determination of novamethymycin, a new bioactive metabolite of the methymycin biosynthetic pathway in Streptomyces venezuelae. Journal of Natural Products. 64: 1447-50. PMID 11720530  0.36
2001 Varoglu M, Mao Y, Sherman DH. Mapping the mitomycin biosynthetic pathway by functional analysis of the MitM aziridine N-methyltransferase. Journal of the American Chemical Society. 123: 6712-3. PMID 11439066  0.72
2001 Kyung YS, Hu WS, Sherman DH. Analysis of temporal and spatial expression of the CcaR regulatory element in the cephamycin C biosynthetic pathway using green fluorescent protein. Molecular Microbiology. 40: 530-41. PMID 11359561 DOI: 10.1046/j.1365-2958.2001.02386.x  0.68
2001 Wilson DJ, Xue Y, Reynolds KA, Sherman DH. Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. Journal of Bacteriology. 183: 3468-75. PMID 11344155 DOI: 10.1128/JB.183.11.3468-3475.2001  1
2001 Chen S, Roberts JB, Xue Y, Sherman DH, Reynolds KA. The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide. Gene. 263: 255-64. PMID 11223265 DOI: 10.1016/S0378-1119(00)00560-6  1
2001 Xue Y, Sherman DH. Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae. Metabolic Engineering. 3: 15-26. PMID 11162229 DOI: 10.1006/mben.2000.0167  1
2001 He M, Sheldon PJ, Sherman DH. Characterization of a quinone reductase activity for the mitomycin C binding protein (MRD): Functional switching from a drug-activating enzyme to a drug-binding protein. Proceedings of the National Academy of Sciences of the United States of America. 98: 926-31. PMID 11158572 DOI: 10.1073/pnas.031314998  0.72
2000 Chen S, Xue Y, Sherman DH, Reynolds KA. Mechanisms of molecular recognition in the pikromycin polyketide synthase. Chemistry & Biology. 7: 907-18. PMID 11137814 DOI: 10.1016/S1074-5521(00)00039-9  1
2000 He M, Varoglu M, Sherman DH. Structural modeling and site-directed mutagenesis of the actinorhodin beta-ketoacyl-acyl carrier protein synthase. Journal of Bacteriology. 182: 2619-23. PMID 10762267  0.72
2000 Xue Y, Wilson D, Sherman DH. Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides. Gene. 245: 203-11. PMID 10713461  1
2000 Xue Y, Sherman DH. Alternative modular polyketide synthase expression controls macrolactone structure. Nature. 403: 571-5. PMID 10676969 DOI: 10.1038/35000624  1
1999 Khetan A, Malmberg LH, Kyung YS, Sherman DH, Hu WS. Precursor and cofactor as a check valve for cephamycin biosynthesis in Streptomyces clavuligerus. Biotechnology Progress. 15: 1020-7. PMID 10585184 DOI: 10.1021/bp990090f  1
1999 Sheldon PJ, Mao Y, He M, Sherman DH. Mitomycin resistance in Streptomyces lavendulae includes a novel drug-binding-protein-dependent export system. Journal of Bacteriology. 181: 2507-12. PMID 10198016  0.72
1999 Mao Y, Varoglu M, Sherman DH. Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564. Chemistry & Biology. 6: 251-63. PMID 10099135 DOI: 10.1016/S1074-5521(99)80040-4  0.72
1999 Mao Y, Varoglu M, Sherman DH. Genetic localization and molecular characterization of two key genes (mitAB) required for biosynthesis of the antitumor antibiotic mitomycin C. Journal of Bacteriology. 181: 2199-208. PMID 10094699  0.72
1998 Xue Y, Wilson D, Zhao L, Liu Hw, Sherman DH. Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae. Chemistry & Biology. 5: 661-7. PMID 9831532  1
1998 Xue Y, Zhao L, Liu HW, Sherman DH. A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity. Proceedings of the National Academy of Sciences of the United States of America. 95: 12111-6. PMID 9770448  1
1984 Kranz DM, Sherman DH, Sitkovsky MV, Pasternack MS, Eisen HN. Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera. Proceedings of the National Academy of Sciences of the United States of America. 81: 573-7. PMID 6607474  1
1984 Sherman DH, Kranz DM, Eisen HN. Expression of structurally diverse Qa-2-encoded molecules on the surface of cloned cytotoxic T lymphocytes. The Journal of Experimental Medicine. 160: 1421-30. PMID 6333483  1
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