Alan P. Kozikowski - Publications

Affiliations: 
University of Illinois at Chicago, Chicago, IL, United States 
Area:
medicinal chemistry
Website:
http://foto.pharm.uic.edu/mcp/people/kozikowski_ap.html

221 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Budke B, Tueckmantel W, Miles K, Kozikowski AP, Connell PP. Optimization of Drug Candidates that Inhibit the D-loop Activity of RAD51. Chemmedchem. PMID 30957434 DOI: 10.1002/cmdc.201900075  0.44
2018 Porter NJ, Shen S, Barinka C, Kozikowski AP, Christianson DW. Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor. Acs Medicinal Chemistry Letters. 9: 1301-1305. PMID 30613344 DOI: 10.1021/acsmedchemlett.8b00487  0.36
2018 Kozikowski A, Shen S, Pardo M, Tavares MT, Szarics D, Benoy V, Zimprich CA, Kutil Z, Zhang G, Barinka C, Robers MB, Van Den Bosch L, Eubanks JH, Jope RS. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome. Acs Chemical Neuroscience. PMID 30511829 DOI: 10.1021/acschemneuro.8b00600  0.36
2018 Benoy V, Van Helleputte L, Prior R, d'Ydewalle C, Haeck W, Geens N, Scheveneels W, Schevenels B, Cader MZ, Talbot K, Kozikowski AP, Vanden Berghe P, Van Damme P, Robberecht W, Van Den Bosch L. HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease. Brain : a Journal of Neurology. PMID 29415205 DOI: 10.1093/brain/awx375  0.36
2017 Tavares MT, Shen S, Knox T, Hadley M, Kutil Z, Bařinka C, Villagra A, Kozikowski AP. Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models. Acs Medicinal Chemistry Letters. 8: 1031-1036. PMID 29057046 DOI: 10.1021/acsmedchemlett.7b00223  0.36
2017 Viljoen A, Herrmann JL, Onajole OK, Stec J, Kozikowski AP, Kremer L. Controlling Extra- and Intramacrophagic Mycobacterium abscessus by Targeting Mycolic Acid Transport. Frontiers in Cellular and Infection Microbiology. 7: 388. PMID 28920054 DOI: 10.3389/fcimb.2017.00388  0.36
2017 Huang J, Wang L, Dahiya S, Beier UH, Han R, Samanta A, Bergman J, Sotomayor EM, Seto E, Kozikowski AP, Hancock WW. Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Scientific Reports. 7: 8626. PMID 28819166 DOI: 10.1038/s41598-017-09211-3  0.32
2017 Kozikowski AP, Onajole OK, Stec J, Dupont C, Viljoen A, Richard M, Chaira T, Lun S, Bishai WR, Raj VS, Ordway D, Kremer L. Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections. Journal of Medicinal Chemistry. PMID 28574259 DOI: 10.1021/acs.jmedchem.7b00582  0.36
2016 Budke B, Lv W, Kozikowski AP, Connell PP. Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy? Chemmedchem. PMID 27781374 DOI: 10.1002/cmdc.201600426  0.44
2016 Zhang HK, Eaton JB, Fedolak A, Gunosewoyo H, Onajole OK, Brunner D, Lukas RJ, Yu LF, Kozikowski AP. Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists. European Journal of Medicinal Chemistry. 124: 689-697. PMID 27639361 DOI: 10.1016/j.ejmech.2016.09.016  0.4
2016 Stec J, Onajole OK, Lun S, Guo H, Merenbloom B, Vistoli G, Bishai WR, Kozikowski AP. Indole-2-carboxamide-Based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection. Journal of Medicinal Chemistry. PMID 27275668 DOI: 10.1021/acs.jmedchem.6b00415  0.56
2016 Lv W, Budke B, Pawlowski M, Connell PP, Kozikowski AP. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. Journal of Medicinal Chemistry. PMID 27049177 DOI: 10.1021/acs.jmedchem.5b01762  0.44
2016 Onajole OK, Vallerini GP, Eaton JB, Lukas RJ, Brunner D, Caldarone BJ, Kozikowski AP. Synthesis and Behavioral Studies of Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile. Part III. Acs Chemical Neuroscience. PMID 27035276 DOI: 10.1021/acschemneuro.6b00050  0.68
2016 Baumgart S, Chen NM, Zhang JS, Billadeau DD, Gaisina I, Kozikowski AP, Singh S, Fink D, Strobel P, Klindt C, Zhang L, Bamlet WR, Koenig A, Hessmann E, Gress T, et al. GSK-3β governs inflammation-induced NFATc2 signaling hubs to promote pancreatic cancer progression. Molecular Cancer Therapeutics. PMID 26823495 DOI: 10.1158/1535-7163.MCT-15-0309  0.68
2016 Lienlaf M, Perez-Villarroel P, Knox T, Pabon M, Sahakian E, Powers J, Woan KV, Lee C, Cheng F, Deng S, Smalley KS, Montecino M, Kozikowski A, Pinilla-Ibarz J, Sarnaik A, et al. Essential role of HDAC6 in the regulation of PD-L1 in melanoma. Molecular Oncology. PMID 26775640 DOI: 10.1016/j.molonc.2015.12.012  0.68
2015 Cheng J, Giguère PM, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Huang XP, Zhu H, McCorvy JD, Wetsel WC, Roth BL, Kozikowski AP. Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models. Journal of Medicinal Chemistry. PMID 26704965 DOI: 10.1021/acs.jmedchem.5b01153  0.68
2015 Lu S, Zhang Y, Kalin JH, Cai L, Kozikowski AP, Pike VW. Exploration of the labeling of [(11) C]tubastatin A at the hydroxamic acid site with [(11) C]carbon monoxide. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 26647018 DOI: 10.1002/jlcr.3360  0.68
2015 Segretti MC, Vallerini GP, Brochier C, Langley B, Wang L, Hancock WW, Kozikowski AP. Thiol-Based Potent and Selective HDAC6 Inhibitors Promote Tubulin Acetylation and T-Regulatory Cell Suppressive Function. Acs Medicinal Chemistry Letters. 6: 1156-1161. PMID 26617971 DOI: 10.1021/acsmedchemlett.5b00303  0.68
2015 Shen S, Kozikowski AP. Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors-What Some May Have Forgotten or Would Rather Forget? Chemmedchem. PMID 26603496 DOI: 10.1002/cmdc.201500486  0.36
2015 Shen S, Benoy V, Bergman JA, Kalin JH, Frojuello M, Vistoli G, Haeck W, Van Den Bosch L, Kozikowski AP. Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease. Acs Chemical Neuroscience. PMID 26599234 DOI: 10.1021/acschemneuro.5b00286  0.68
2015 Gaisina IN, Tueckmantel W, Ugolkov A, Shen S, Hoffen J, Dubrovskyi O, Mazar A, Schoon RA, Billadeau D, Kozikowski AP. Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity. Chemmedchem. PMID 26592932 DOI: 10.1002/cmdc.201500456  0.36
2015 Woan KV, Lienlaf M, Perez-Villaroel P, Lee C, Cheng F, Knox T, Woods DM, Barrios K, Powers J, Sahakian E, Wang HW, Canales J, Marante D, Smalley KS, Bergman J, ... ... Kozikowski A, et al. Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation. Molecular Oncology. PMID 25957812 DOI: 10.1016/j.molonc.2015.04.002  0.68
2015 Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP. Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents. Journal of Medicinal Chemistry. 58: 1992-2002. PMID 25633969 DOI: 10.1021/jm5019274  0.68
2015 Winglee K, Lun S, Pieroni M, Kozikowski A, Bishai W. Mutation of Rv2887, a marR-Like gene, confers mycobacterium tuberculosis resistance to an imidazopyridine-based agent Antimicrobial Agents and Chemotherapy. 59: 6873-6881. DOI: 10.1128/AAC.01341-15  0.68
2015 Cheng J, Giguere PM, Lv W, Roth BL, Kozikowski AP. Design and synthesis of (2-(5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a selective serotonin 2C agonist This Letter is dedicated to the lasting memory of Harry H. Wasserman, a connoisseur of heterocycles Tetrahedron Letters. 56: 3420-3422. DOI: 10.1016/j.tetlet.2015.01.060  0.68
2014 Yu LF, Brek Eaton J, Zhang HK, Sabath E, Hanania T, Li GN, van Breemen RB, Whiteaker P, Liu Q, Wu J, Chang YC, Lukas RJ, Brunner D, Kozikowski AP. The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile. Pharmacology Research & Perspectives. 2: e00026. PMID 25505580 DOI: 10.1002/prp2.26  0.44
2014 Onajole OK, Eaton JB, Lukas RJ, Brunner D, Thiede L, Caldarone BJ, Kozikowski AP. Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4β2-nAChR Ligands. Acs Medicinal Chemistry Letters. 5: 1196-201. PMID 25408831 DOI: 10.1021/ml500129k  0.68
2014 Stec J, Vilchèze C, Lun S, Perryman AL, Wang X, Freundlich JS, Bishai W, Jacobs WR, Kozikowski AP. Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis. Chemmedchem. 9: 2528-37. PMID 25165007 DOI: 10.1002/cmdc.201402255  0.68
2014 Cheng F, Lienlaf M, Wang HW, Perez-Villarroel P, Lee C, Woan K, Rock-Klotz J, Sahakian E, Woods D, Pinilla-Ibarz J, Kalin J, Tao J, Hancock W, Kozikowski A, Seto E, et al. A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs. Journal of Immunology (Baltimore, Md. : 1950). 193: 2850-62. PMID 25108026 DOI: 10.4049/jimmunol.1302778  0.68
2014 Yu LF, Zhang HK, Caldarone BJ, Eaton JB, Lukas RJ, Kozikowski AP. Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. Journal of Medicinal Chemistry. 57: 8204-23. PMID 24901260 DOI: 10.1021/jm401937a  0.68
2014 Mason JM, Logan HL, Budke B, Wu M, Pawlowski M, Weichselbaum RR, Kozikowski AP, Bishop DK, Connell PP. The rad51-stimulatory compound rs-1 can exploit the rad51 overexpression that exists in cancer cells and tumors Cancer Research. 74: 3546-3555. PMID 24753542 DOI: 10.1158/0008-5472.CAN-13-3220  0.68
2014 Cheng F, Lienlaf M, Perez-Villarroel P, Wang HW, Lee C, Woan K, Woods D, Knox T, Bergman J, Pinilla-Ibarz J, Kozikowski A, Seto E, Sotomayor EM, Villagra A. Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells. Molecular Immunology. 60: 44-53. PMID 24747960 DOI: 10.1016/j.molimm.2014.02.019  0.68
2014 Xu X, Kozikowski AP, Pozzo-Miller L. A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome. Frontiers in Cellular Neuroscience. 8: 68. PMID 24639629 DOI: 10.3389/fncel.2014.00068  0.68
2014 Selenica ML, Benner L, Housley SB, Manchec B, Lee DC, Nash KR, Kalin J, Bergman JA, Kozikowski A, Gordon MN, Morgan D. Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition. Alzheimer's Research & Therapy. 6: 12. PMID 24576665 DOI: 10.1186/alzrt241  0.68
2014 Pal K, Cao Y, Gaisina IN, Bhattacharya S, Dutta SK, Wang E, Gunosewoyo H, Kozikowski AP, Billadeau DD, Mukhopadhyay D. Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer. Molecular Cancer Therapeutics. 13: 285-96. PMID 24327518 DOI: 10.1158/1535-7163.MCT-13-0681  0.68
2013 Lun S, Guo H, Onajole OK, Pieroni M, Gunosewoyo H, Chen G, Tipparaju SK, Ammerman NC, Kozikowski AP, Bishai WR. Indoleamides are active against drug-resistant mycobacterium tuberculosis Nature Communications. 4. PMID 24352433 DOI: 10.1038/ncomms3907  0.68
2013 Afanador GA, Muench SP, McPhillie M, Fomovska A, Schön A, Zhou Y, Cheng G, Stec J, Freundlich JS, Shieh HM, Anderson JW, Jacobus DP, Fidock DA, Kozikowski AP, Fishwick CW, et al. Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay. Biochemistry. 52: 9155-66. PMID 24295325 DOI: 10.1021/bi400945y  0.68
2013 Lwin T, Zhao X, Cheng F, Zhang X, Huang A, Shah B, Zhang Y, Moscinski LC, Choi YS, Kozikowski AP, Bradner JE, Dalton WS, Sotomayor E, Tao J. A microenvironment-mediated c-Myc/miR-548m/HDAC6 amplification loop in non-Hodgkin B cell lymphomas. The Journal of Clinical Investigation. 123: 4612-26. PMID 24216476 DOI: 10.1172/JCI64210  0.68
2013 De Narvajas AAM, Gomez TS, Zhang JS, Mann AO, Taoda Y, Gorman JA, Herreros-Villanueva M, Gress TM, Ellenrieder V, Bujand L, Kim DH, Kozikowski AP, Koenig A, Billadeau DD. Epigenetic regulation of autophagy by the methyltransferase G9a Molecular and Cellular Biology. 33: 3983-3993. PMID 23918802 DOI: 10.1128/MCB.00813-13  0.68
2013 Stec J, Fomovska A, Afanador GA, Muench SP, Zhou Y, Lai BS, El Bissati K, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Sommervile C, Woods S, Roberts CW, Rice D, ... ... Kozikowski AP, et al. Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii. Chemmedchem. 8: 1138-60. PMID 23776166 DOI: 10.1002/cmdc.201300050  0.68
2013 Zhang HK, Yu LF, Eaton JB, Whiteaker P, Onajole OK, Hanania T, Brunner D, Lukas RJ, Kozikowski AP. Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II. Journal of Medicinal Chemistry. 56: 5495-504. PMID 23734673 DOI: 10.1021/jm400510u  0.68
2013 Gunosewoyo H, Midzak A, Gaisina IN, Sabath EV, Fedolak A, Hanania T, Brunner D, Papadopoulos V, Kozikowski AP. Characterization of maleimide-based glycogen synthase kinase-3 (GSK-3) inhibitors as stimulators of steroidogenesis. Journal of Medicinal Chemistry. 56: 5115-29. PMID 23725591 DOI: 10.1021/jm400511s  0.68
2013 Onajole OK, Pieroni M, Tipparaju SK, Lun S, Stec J, Chen G, Gunosewoyo H, Guo H, Ammerman NC, Bishai WR, Kozikowski AP. Preliminary structure - Activity relationships and biological evaluation of novel antitubercular indolecarboxamide derivatives against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains Journal of Medicinal Chemistry. 56: 4093-4103. PMID 23611124 DOI: 10.1021/jm4003878  0.68
2013 Gunosewoyo H, Tipparaju SK, Pieroni M, Wang Y, Doctor BP, Nambiar MP, Kozikowski AP. Structural analogs of huperzine A improve survival in guinea pigs exposed to soman. Bioorganic & Medicinal Chemistry Letters. 23: 1544-7. PMID 23395652 DOI: 10.1016/j.bmcl.2012.11.083  0.68
2013 Yuan Y, Yu LF, Qiu X, Kozikowski AP, Van Breemen RB. Pharmacokinetics and brain penetration of LF-3-88, (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol), a selective α4β2-nAChR partial agonist and promising antidepressant Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 912: 38-42. PMID 23246847 DOI: 10.1016/j.jchromb.2012.11.011  0.68
2013 Budke B, Kalin JH, Pawlowski M, Zelivianskaia AS, Wu M, Kozikowski AP, Connell PP. An optimized RAD51 inhibitor that disrupts homologous recombination without requiring michael acceptor reactivity Journal of Medicinal Chemistry. 56: 254-263. PMID 23231413 DOI: 10.1021/jm301565b  0.68
2012 Yu LF, Zhang HK, Gunosewoyo H, Kozikowski AP. From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design. Acs Medicinal Chemistry Letters. 3: 1054-1058. PMID 23641311 DOI: 10.1021/ml3002715  0.4
2012 Cho SY, Gage KL, Mease RC, Senthamizhchelvan S, Holt DP, Jeffrey-Kwanisai A, Endres CJ, Dannals RF, Sgouros G, Lodge M, Eisenberger MA, Rodriguez R, Carducci MA, Rojas C, Slusher BS, ... Kozikowski AP, et al. Biodistribution, tumor detection, and radiation dosimetry of 18F-DCFBC, a low-molecular-weight inhibitor of prostate-specific membrane antigen, in patients with metastatic prostate cancer. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 53: 1883-91. PMID 23203246 DOI: 10.2967/jnumed.112.104661  0.68
2012 Yu LF, Eaton JB, Fedolak A, Zhang HK, Hanania T, Brunner D, Lukas RJ, Kozikowski AP. Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II. Journal of Medicinal Chemistry. 55: 9998-10009. PMID 23092294 DOI: 10.1021/jm301177j  0.68
2012 Bergman JA, Woan K, Perez-Villarroel P, Villagra A, Sotomayor EM, Kozikowski AP. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. Journal of Medicinal Chemistry. 55: 9891-9. PMID 23009203 DOI: 10.1021/jm301098e  0.68
2012 Zhang HK, Eaton JB, Yu LF, Nys M, Mazzolari A, van Elk R, Smit AB, Alexandrov V, Hanania T, Sabath E, Fedolak A, Brunner D, Lukas RJ, Vistoli G, Ulens C, ... Kozikowski AP, et al. Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands. Journal of Medicinal Chemistry. 55: 8028-37. PMID 22928944 DOI: 10.1021/jm3008739  0.68
2012 Gills JJ, Zhang C, Abu-Asab MS, Castillo SS, Marceau C, LoPiccolo J, Kozikowski AP, Tsokos M, Goldkorn T, Dennis PA. Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine Cell Death and Disease. 3. PMID 22764099 DOI: 10.1038/cddis.2012.72  0.68
2012 Budke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL, Stark JM, Kozikowski AP, Bishop DK, Connell PP. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Research. 40: 7347-57. PMID 22573178 DOI: 10.1093/nar/gks353  0.68
2012 Fomovska A, Huang Q, El Bissati K, Mui EJ, Witola WH, Cheng G, Zhou Y, Sommerville C, Roberts CW, Bettis S, Prigge ST, Afanador GA, Hickman MR, Lee PJ, Leed SE, ... ... Kozikowski AP, et al. Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway. Antimicrobial Agents and Chemotherapy. 56: 2666-82. PMID 22354304 DOI: 10.1128/AAC.06450-11  0.68
2012 Stec J, Huang Q, Pieroni M, Kaiser M, Fomovska A, Mui E, Witola WH, Bettis S, McLeod R, Brun R, Kozikowski AP. Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania. Journal of Medicinal Chemistry. 55: 3088-100. PMID 22352841 DOI: 10.1021/jm2015183  0.68
2012 Chen PC, Gaisina IN, El-Khodor BF, Ramboz S, Makhortova NR, Rubin LL, Kozikowski AP. Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of Δ7 SMA KO Mouse Model of Spinal Muscular Atrophy. Acs Chemical Neuroscience. 3: 5-11. PMID 22348181 DOI: 10.1021/cn200085z  0.68
2012 Lilienkampf A, Pieroni M, Franzblau SG, Bishai WR, Kozikowski AP. Derivatives of 3-isoxazolecarboxylic acid esters - a potent and selective compound class against replicating and nonreplicating Mycobacterium tuberculosis Current Topics in Medicinal Chemistry. 12: 729-734. PMID 22283815 DOI: 10.2174/156802612799984544  0.68
2012 Kalin JH, Zhang H, Gaudrel-Grosay S, Vistoli G, Kozikowski AP. Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress Chemmedchem. 7: 425-439. PMID 22234885 DOI: 10.1002/cmdc.201100522  0.68
2012 Zhang H, Tückmantel W, Eaton JB, Yuen PW, Yu LF, Bajjuri KM, Fedolak A, Wang D, Ghavami A, Caldarone B, Paterson NE, Lowe DA, Brunner D, Lukas RJ, Kozikowski AP. Chemistry and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Journal of Medicinal Chemistry. 55: 717-24. PMID 22171543 DOI: 10.1021/jm201157c  0.56
2012 Kalin JH, Butler KV, Akimova T, Hancock WW, Kozikowski AP. Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells Journal of Medicinal Chemistry. 55: 639-651. PMID 22165909 DOI: 10.1021/jm200773h  0.68
2012 Yu LF, Tückmantel W, Eaton JB, Caldarone B, Fedolak A, Hanania T, Brunner D, Lukas RJ, Kozikowski AP. Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity. Journal of Medicinal Chemistry. 55: 812-23. PMID 22148173 DOI: 10.1021/jm201301h  0.68
2012 Yu LF, Zhang HK, Gunosewoyo H, Kozikowski AP. From α4β2 nicotinic ligands to the discovery of σ1 receptor ligands: Pharmacophore analysis and rational design Acs Medicinal Chemistry Letters. 3: 1054-1058. DOI: 10.1021/ml3002715  0.68
2011 Chen G, Cho SJ, Huang XP, Jensen NH, Svennebring A, Sassano MF, Roth BL, Kozikowski AP. Rational Drug Design Leading to the Identification of a Potent 5-HT(2C) Agonist Lacking 5-HT(2B) Activity. Acs Medicinal Chemistry Letters. 2: 929-932. PMID 22778800 DOI: 10.1021/ml200206z  0.68
2011 D'Ydewalle C, Krishnan J, Chiheb DM, Van Damme P, Irobi J, Kozikowski AP, Berghe PV, Timmerman V, Robberecht W, Van Den Bosch L. HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease Nature Medicine. 17: 968-974. PMID 21785432 DOI: 10.1038/nm.2396  0.68
2011 Chen W, Gaisina IN, Gunosewoyo H, Malekiani SA, Hanania T, Kozikowski AP. Structure-guided design of a highly selective glycogen synthase kinase-3β inhibitor: a superior neuroprotective pyrazolone showing antimania effects. Chemmedchem. 6: 1587-92. PMID 21751402 DOI: 10.1002/cmdc.201100231  0.68
2011 Kozikowski AP, Gunosewoyo H, Guo S, Gaisina IN, Walter RL, Ketcherside A, McClung CA, Mesecar AD, Caldarone B. Identification of a glycogen synthase kinase-3β inhibitor that attenuates hyperactivity in CLOCK mutant mice. Chemmedchem. 6: 1593-602. PMID 21732538 DOI: 10.1002/cmdc.201100188  0.68
2011 Kozikowski AP. On the path from chemistry to neuroscience: Early explorations in chemical medicine under the mentorship of Dr. Erminio Costa, a neuroscientist with a big brain and a bigger heart Pharmacological Research. 64: 327-329. PMID 21708253 DOI: 10.1016/j.phrs.2011.05.025  0.68
2011 Caldarone BJ, Wang D, Paterson NE, Manzano M, Fedolak A, Cavino K, Kwan M, Hanania T, Chellappan SK, Kozikowski AP, Olivier B, Picciotto MR, Ghavami A. Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380. Psychopharmacology. 217: 199-210. PMID 21487659 DOI: 10.1007/s00213-011-2271-y  0.68
2011 de Zoeten EF, Wang L, Butler K, Beier UH, Akimova T, Sai H, Bradner JE, Mazitschek R, Kozikowski AP, Matthias P, Hancock WW. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3+ T-regulatory cells Molecular and Cellular Biology. 31: 2066-2078. PMID 21444725 DOI: 10.1128/MCB.05155-11  0.68
2011 Kozikowski AP, Neale JH. Effective Collaborations: How to Protect Yourself, Your Collaborators, and Your Data Chemmedchem. 6: 411-414. PMID 21360815 DOI: 10.1002/cmdc.201000529  0.68
2011 Huang Q, He R, Kozikowski AP. Stereochemistry at the forefront in the design and discovery of novel anti-tuberculosis agents Current Topics in Medicinal Chemistry. 11: 810-818. PMID 21291395 DOI: 10.2174/156802611795165205  0.68
2011 Kozikowski A, Botta M. Location, Location, Location Chemmedchem. 6: 211-213. PMID 21275042 DOI: 10.1002/cmdc.200000528  0.68
2011 Pieroni M, Tipparaju SK, Lun S, Song Y, Sturm AW, Bishai WR, Kozikowski AP. Pyrido[1,2-a]benzimidazole-Based Agents Active Against Tuberculosis (TB), Multidrug-Resistant (MDR) TB and Extensively Drug-Resistant (XDR) TB Chemmedchem. 6: 334-342. PMID 21259445 DOI: 10.1002/cmdc.201000490  0.68
2011 Malkova L, Kozikowski AP, Gale K. The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. Neuropharmacology. 60: 1262-8. PMID 21185313 DOI: 10.1016/j.neuropharm.2010.12.018  0.68
2010 Caldarone BJ, Paterson NE, Zhou J, Brunner D, Kozikowski AP, Westphal KG, Korte-Bouws GA, Prins J, Korte SM, Olivier B, Ghavami A. The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. The Journal of Pharmacology and Experimental Therapeutics. 335: 762-70. PMID 20864506 DOI: 10.1124/jpet.110.174011  0.68
2010 Liu J, Eaton JB, Caldarone B, Lukas RJ, Kozikowski AP. Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as α4β2-nicotinic acetylcholine receptor-selective partial agonists. Journal of Medicinal Chemistry. 53: 6973-85. PMID 20822184 DOI: 10.1021/jm100765u  0.68
2010 Pieroni M, Lilienkampf A, Wang Y, Wan B, Cho S, Franzblau SG, Kozikowski AP. NOC chemistry for tuberculosis - Further investigations on the structure-activity relationships of antitubercular isoxazole-3-carboxylic acid ester derivatives Chemmedchem. 5: 1667-1672. PMID 20718072 DOI: 10.1002/cmdc.201000169  0.68
2010 Tipparaju SK, Muench SP, Mui EJ, Ruzheinikov SN, Lu JZ, Hutson SL, Kirisits MJ, Prigge ST, Roberts CW, Henriquez FL, Kozikowski AP, Rice DW, McLeod RL. Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase. Journal of Medicinal Chemistry. 53: 6287-300. PMID 20698542 DOI: 10.1021/jm9017724  0.68
2010 Butler KV, Kalin J, Brochier C, Vistoli G, Langley B, Kozikowski AP. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A Journal of the American Chemical Society. 132: 10842-10846. PMID 20614936 DOI: 10.1021/ja102758v  0.68
2010 Kozikowski AP, Cho SJ, Jensen NH, Allen JA, Svennebring AM, Roth BL. HTS and rational drug design to generate a class of 5-HT(2C)-selective ligands for possible use in schizophrenia. Chemmedchem. 5: 1221-5. PMID 20533502 DOI: 10.1002/cmdc.201000186  0.68
2010 Smirnova NA, Rakhman I, Moroz N, Basso M, Payappilly J, Kazakov S, Hernandez-Guzman F, Gaisina IN, Kozikowski AP, Ratan RR, Gazaryan IG. Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. Chemistry & Biology. 17: 380-91. PMID 20416509 DOI: 10.1016/j.chembiol.2010.03.008  0.68
2010 He R, Chen Y, Ougolkov AV, Zhang JS, Savoy DN, Billadeau DD, Kozikowski AP. Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents Journal of Medicinal Chemistry. 53: 1347-1356. PMID 20055418 DOI: 10.1021/jm901667k  0.68
2010 Lilienkampf A, Pieroni M, Wan B, Wang Y, Franzblau SG, Kozikowski AP. Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. A potent and selective series for further drug development Journal of Medicinal Chemistry. 53: 678-688. PMID 20000577 DOI: 10.1021/jm901273n  0.68
2010 Guo S, Song Y, Huang Q, Yuan H, Wan B, Wang Y, He R, Beconi MG, Franzblau SG, Kozikowski AP. Identification, synthesis, and pharmacological evaluation of tetrahydroindazole based ligands as novel antituberculosis agents Journal of Medicinal Chemistry. 53: 649-659. PMID 20000470 DOI: 10.1021/jm901235p  0.68
2009 Rivieccio MA, Brochier C, Willis DE, Walker BA, D'Annibale MA, McLaughlin K, Siddiq A, Kozikowski AP, Jaffrey SR, Twiss JL, Ratan RR, Langley B. HDAC6 is a target for protection and regeneration following injury in the nervous system. Proceedings of the National Academy of Sciences of the United States of America. 106: 19599-604. PMID 19884510 DOI: 10.1073/pnas.0907935106  0.68
2009 Mao J, Yuan H, Wang Y, Wan B, Pieroni M, Huang Q, Van Breemen RB, Kozikowski AP, Franzblau SG. From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters Journal of Medicinal Chemistry. 52: 6966-6978. PMID 19863050 DOI: 10.1021/jm900340a  0.68
2009 Huang Q, Mao J, Wan B, Wang Y, Brun R, Franzblau SG, Kozikowski AP. Searching for new cures for tuberculosis: Design, synthesis, and biological evaluation of 2-methylbenzothiazoles Journal of Medicinal Chemistry. 52: 6757-6767. PMID 19817445 DOI: 10.1021/jm901112f  0.68
2009 Guo S, Tipparaju SK, Pegan SD, Wan B, Mo S, Orjala J, Mesecar AD, Franzblau SG, Kozikowski AP. Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents. Bioorganic & Medicinal Chemistry. 17: 7126-30. PMID 19783449 DOI: 10.1016/j.bmc.2009.08.061  0.68
2009 Pieroni M, Lilienkampf A, Baojie W, Yuehong W, Franzblau SG, Kozikowski AP. Synthesis, biological evaluation, and structure-activity relationships for 5-[(E)-2-arylethenyl]-3-isoxazolecarboxylic acid alkyl ester derivatives as valuable antitubercular chemotypes Journal of Medicinal Chemistry. 52: 6287-6296. PMID 19757815 DOI: 10.1021/jm900513a  0.68
2009 Valette H, Xiao Y, Peyronneau MA, Damont A, Kozikowski AP, Wei ZL, Kassiou M, Kellar KJ, Dollé F, Bottlaender M. 18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors--in vitro binding properties and PET studies in baboons. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 50: 1349-55. PMID 19652217 DOI: 10.2967/jnumed.108.061374  0.68
2009 Kozikowski AP, Eaton JB, Bajjuri KM, Chellappan SK, Chen Y, Karadi S, He R, Caldarone B, Manzano M, Yuen PW, Lukas RJ. Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depression. Chemmedchem. 4: 1279-91. PMID 19569163 DOI: 10.1002/cmdc.200900079  0.68
2009 Butler KV, He R, McLaughlin K, Vistoli G, Langley B, Kozikowski AP. Stereoselective HDAC inhibition from cysteine-derived zinc-binding groups. Chemmedchem. 4: 1292-301. PMID 19551801 DOI: 10.1002/cmdc.200900088  0.68
2009 Kalin JH, Butler KV, Kozikowski AP. Creating zinc monkey wrenches in the treatment of epigenetic disorders Current Opinion in Chemical Biology. 13: 263-271. PMID 19541531 DOI: 10.1016/j.cbpa.2009.05.007  0.68
2009 Kim KH, Gaisina I, Gallier F, Holzle D, Blond SY, Mesecar A, Kozikowski AP. Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl) maleimides as GSK-3β inhibitors Journal of Molecular Modeling. 15: 1463-1479. PMID 19440740 DOI: 10.1007/s00894-009-0498-x  0.68
2009 Tapadar S, He R, Luchini DN, Billadeau DD, Kozikowski AP. Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity Bioorganic and Medicinal Chemistry Letters. 19: 3023-3026. PMID 19419863 DOI: 10.1016/j.bmcl.2009.04.058  0.68
2009 Kozikowski AP, Chen Y, Subhasish T, Lewin NE, Blumberg PM, Zhong Z, D'Annibale MA, Wang WL, Shen Y, Langley B. Searching for disease modifiers - PKC activation and HDAC inhibition - A dual drug approach to Alzheimer's disease that decreases Aβ production while blocking oxidative stress Chemmedchem. 4: 1095-1105. PMID 19396896 DOI: 10.1002/cmdc.200900045  0.68
2009 Sleiman SF, Basso M, Mahishi L, Kozikowski AP, Donohoe ME, Langley B, Ratan RR. Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions. Expert Opinion On Investigational Drugs. 18: 573-84. PMID 19388875 DOI: 10.1517/13543780902810345  0.68
2009 Chen Y, He R, D'Annibale MA, Langley B, Kozikowski AP. Studies of benzamide- and thiol-based histone deacetylase inhibitors in models of oxidative-stress-induced neuronal death: Identification of some HDAC3-selective inhibitors Chemmedchem. 4: 842-852. PMID 19350613 DOI: 10.1002/cmdc.200800461  0.68
2009 Gaisina IN, Gallier F, Ougolkov AV, Kim KH, Kurome T, Guo S, Holzle D, Luchini DN, Blond SY, Billadeau DD, Kozikowski AP. From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3βinhibitors that suppress proliferation and survival of pancreatic cancer cells Journal of Medicinal Chemistry. 52: 1853-1863. PMID 19338355 DOI: 10.1021/jm801317h  0.68
2009 Cho SJ, Jensen NH, Kurome T, Kadari S, Manzano ML, Malberg JE, Caldarone B, Roth BL, Kozikowski AP. Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action. Journal of Medicinal Chemistry. 52: 1885-902. PMID 19284718 DOI: 10.1021/jm801354e  0.68
2009 Lilienkampf A, Jialin M, Baojie W, Yuehong W, Franzblau SG, Kozikowski AP. Structure-Activity relationships for a series of quinoline-based compounds active against replicating and nonreplicating mycobacterium tuberculosis Journal of Medicinal Chemistry. 52: 2109-2118. PMID 19271749 DOI: 10.1021/jm900003c  0.68
2009 Tang H, Wang XS, Huang XP, Roth BL, Butler KV, Kozikowski AP, Jung M, Tropsha A. Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation. Journal of Chemical Information and Modeling. 49: 461-76. PMID 19182860 DOI: 10.1021/ci800366f  0.68
2009 Maresca KP, Hillier SM, Femia FJ, Keith D, Barone C, Joyal JL, Zimmerman CN, Kozikowski AP, Barrett JA, Eckelman WC, Babich JW. A series of halogenated heterodimeric inhibitors of prostate specific membrane antigen (PSMA) as radiolabeled probes for targeting prostate cancer. Journal of Medicinal Chemistry. 52: 347-57. PMID 19111054 DOI: 10.1021/jm800994j  0.68
2009 Chirapu SR, Pachaiyappan B, Nural HF, Cheng X, Yuan H, Lankin DC, Abdul-Hay SO, Thatcher GR, Shen Y, Kozikowski AP, Petukhov PA. Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 264-74. PMID 19013792 DOI: 10.1016/j.bmcl.2008.10.096  0.68
2009 LaPointe NE, Morfini G, Pigino G, Gaisina IN, Kozikowski AP, Binder LI, Brady ST. The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity. Journal of Neuroscience Research. 87: 440-51. PMID 18798283 DOI: 10.1002/jnr.21850  0.68
2009 Kozikowski AP. Use in the Synthesis of Non-heterocycles Comprehensive Heterocyclic Chemistry. 1: 413-491. DOI: 10.1016/B978-008096519-2.00016-3  0.68
2009 Kozikowski AP, Tückmantel W. Methods for Synthesizing the Cocoa-Derived Oligomeric Epi-Catechins - Observations on the Anticancer Activity of the Cocoa Polyphenols Recent Advances in Polyphenol Research. 1: 88-112. DOI: 10.1002/9781444302400.ch4  0.68
2008 Barinka C, Byun Y, Dusich CL, Banerjee SR, Chen Y, Castanares M, Kozikowski AP, Mease RC, Pomper MG, Lubkowski J. Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: Structural characterization Journal of Medicinal Chemistry. 51: 7737-7743. PMID 19053759 DOI: 10.1021/jm800765e  0.68
2008 Tipparaju SK, Joyasawal S, Pieroni M, Kaiser M, Brun R, Kozikowski AP. In pursuit of natural product leads: Synthesis and biological evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4- carboxylic acid (A-33853) and its analogues: Discovery of N-(2-benzoxazol-2- ylphenyl)benzamides as novel antileishmanial chemotypes Journal of Medicinal Chemistry. 51: 7344-7347. PMID 18989953 DOI: 10.1021/jm801241n  0.68
2008 Pibiri F, Kozikowski AP, Pinna G, Auta J, Kadriu B, Costa E, Guidotti A. The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 14169-74. PMID 18784370 DOI: 10.1073/pnas.0807172105  0.68
2008 Mao J, Eoh H, He R, Wang Y, Wan B, Franzblau SG, Crick DC, Kozikowski AP. Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorganic & Medicinal Chemistry Letters. 18: 5320-3. PMID 18783951 DOI: 10.1016/j.bmcl.2008.08.034  0.68
2008 Yuan H, He R, Wan B, Wang Y, Pauli GF, Franzblau SG, Kozikowski AP. Modification of the side chain of micromolide, an anti-tuberculosis natural product Bioorganic and Medicinal Chemistry Letters. 18: 5311-5315. PMID 18774716 DOI: 10.1016/j.bmcl.2008.08.027  0.68
2008 Tipparaju SK, Mulhearn DC, Klein GM, Chen Y, Tapadar S, Bishop MH, Yang S, Chen J, Ghassemi M, Santarsiero BD, Cook JL, Johlfs M, Mesecar AD, Johnson ME, Kozikowski AP. Design and synthesis of aryl ether inhibitors of the Bacillus anthracis enoyl-ACP reductase. Chemmedchem. 3: 1250-68. PMID 18663709 DOI: 10.1002/cmdc.200800047  0.68
2008 Dow GS, Chen Y, Andrews KT, Caridha D, Gerena L, Gettayacamin M, Johnson J, Li Q, Melendez V, Obaldia N, Tran TN, Kozikowski AP. Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors Antimicrobial Agents and Chemotherapy. 52: 3467-3477. PMID 18644969 DOI: 10.1128/AAC.00439-08  0.68
2008 Kozikowski AP, Tapadar S, Luchini DN, Ki HK, Billadeau DD. Use of the Nitrile Oxide Cycloaddition (NOC) reaction for molecular probe generation: A new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6 Journal of Medicinal Chemistry. 51: 4370-4373. PMID 18642892 DOI: 10.1021/jm8002894  0.68
2008 Banerjee SR, Foss CA, Castanares M, Mease RC, Byun Y, Fox JJ, Hilton J, Lupold SE, Kozikowski AP, Pomper MG. Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA) Journal of Medicinal Chemistry. 51: 4504-4517. PMID 18637669 DOI: 10.1021/jm800111u  0.68
2008 Zhang B, West EJ, Van KC, Gurkoff GG, Zhou J, Zhang XM, Kozikowski AP, Lyeth BG. HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats. Brain Research. 1226: 181-91. PMID 18582446 DOI: 10.1016/j.brainres.2008.05.085  0.68
2008 Sanchez-Pernaute R, Wang JQ, Kuruppu D, Cao L, Tueckmantel W, Kozikowski A, Isacson O, Brownell AL. Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates. Neuroimage. 42: 248-51. PMID 18501638 DOI: 10.1016/j.neuroimage.2008.04.170  0.68
2008 Tipparaju SK, Joyasawal S, Forrester S, Mulhearn DC, Pegan S, Johnson ME, Mesecar AD, Kozikowski AP. Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase. Bioorganic & Medicinal Chemistry Letters. 18: 3565-9. PMID 18499454 DOI: 10.1016/j.bmcl.2008.05.004  0.68
2008 Chen Y, Lopez-Sanchez M, Savoy DN, Billadeau DD, Dow GS, Kozikowski AP. A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum Journal of Medicinal Chemistry. 51: 3437-3448. PMID 18494463 DOI: 10.1021/jm701606b  0.68
2008 Mease RC, Dusich CL, Foss CA, Ravert HT, Dannals RF, Seidel J, Prideaux A, Fox JJ, Sgouros G, Kozikowski AP, Pomper MG. N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl-L- cysteine, [18F]DCFBC: A new Imaging probe for prostate cancer Clinical Cancer Research. 14: 3036-3043. PMID 18483369 DOI: 10.1158/1078-0432.CCR-07-1517  0.68
2008 Butler KV, Kozikowski AP. Chemical origins of isoform selectivity in histone deacetylase inhibitors Current Pharmaceutical Design. 14: 505-528. PMID 18336297 DOI: 10.2174/138161208783885353  0.68
2008 Kozikowski AP, Reitz AB. Filling the pipeline for neglected diseases: creation of a medicinal chemistry-centric international drug discovery institute [iDDi] Drug Discovery Today. 13: 97-98. PMID 18275906 DOI: 10.1016/j.drudis.2007.12.003  0.68
2008 Guilarte TR, Hammoud DA, McGlothan JL, Caffo BS, Foss CA, Kozikowski AP, Pomper MG. Dysregulation of glutamate carboxypeptidase II in psychiatric disease Schizophrenia Research. 99: 324-332. PMID 18191545 DOI: 10.1016/j.schres.2007.11.013  0.68
2008 Kozikowski AP, Chen Y, Gaysin AM, Savoy DN, Billadeau DD, Kim KH. Chemistry, biology, and QSAR studies of substituted biaryl hydroxamates and mercaptoacetamides as HDAC inhibitors - Nanomolar-potency inhibitors of pancreatic cancer cell growth Chemmedchem. 3: 487-501. PMID 18181121 DOI: 10.1002/cmdc.200700314  0.68
2008 Olszewski RT, Wegorzewska MM, Monteiro AC, Krolikowski KA, Zhou J, Kozikowski AP, Long K, Mastropaolo J, Deutsch SI, Neale JH. Phencyclidine and Dizocilpine Induced Behaviors Reduced by N-acetylaspartylglutamate Peptidase Inhibition via Metabotropic Glutamate Receptors Biological Psychiatry. 63: 86-91. PMID 17597589 DOI: 10.1016/j.biopsych.2007.04.016  0.68
2007 Niemitz M, Laatikainen R, Chen SN, Kieps R, Kozikowski AP, Pauli GF. Complete 1H NMR spectral fingerprint of huperzine A Magnetic Resonance in Chemistry. 45: 878-882. PMID 17729231 DOI: 10.1002/mrc.2061  0.68
2007 Mao J, Wang Y, Wan B, Kozikowski AP, Franzblau SG. Design, synthesis, and pharmacological evaluation of mefloquine-based ligands as novel antituberculosis agents Chemmedchem. 2: 1624-1630. PMID 17680579 DOI: 10.1002/cmdc.200700112  0.68
2007 Gills JJ, Castillo SS, Zhang C, Petukhov PA, Memmott RM, Hollingshead M, Warfel N, Han J, Kozikowski AP, Dennis PA. Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38α, through MKK3/6-independent and -dependent mechanisms Journal of Biological Chemistry. 282: 27020-27029. PMID 17631503 DOI: 10.1074/jbc.M701108200  0.68
2007 Kozikowski AP, Gaisina IN, Yuan H, Petukhov PA, Blond SY, Fedolak A, Caldarone B, McGonigle P. Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders. Journal of the American Chemical Society. 129: 8328-32. PMID 17552518 DOI: 10.1021/ja068969w  0.68
2007 Kozikowski AP, Chen Y, Gaysin A, Chen B, D'Annibale MA, Suto CM, Langley BC. Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies. Journal of Medicinal Chemistry. 50: 3054-61. PMID 17539623 DOI: 10.1021/jm070178x  0.68
2007 Kozikowski AP, Chellappan SK, Xiao Y, Bajjuri KM, Yuan H, Kellar KJ, Petukhov PA. Chemical medicine: novel 10-substituted cytisine derivatives with increased selectivity for alpha4beta2 nicotinic acetylcholine receptors. Chemmedchem. 2: 1157-61. PMID 17530728 DOI: 10.1002/cmdc.200700073  0.68
2007 Mao J, Wan B, Wang Y, Franzblau SG, Kozikowski AP. HTS, chemical hybridization, and drug design identify a chemically unique antituberculosis agent-coupling serendipity and rational approaches to drug discovery. Chemmedchem. 2: 811-3. PMID 17455191 DOI: 10.1002/cmdc.200700048  0.68
2007 Tang L, Chen Y, Chen Z, Blumberg PM, Kozikowski AP, Wang ZJ. Antinociceptive pharmacology of N-(4-chlorobenzyl)-N'-(4-hydroxy-3-iodo-5-methoxybenzyl) thiourea, a high-affinity competitive antagonist of the transient receptor potential vanilloid 1 receptor. The Journal of Pharmacology and Experimental Therapeutics. 321: 791-8. PMID 17312187 DOI: 10.1124/jpet.106.117572  0.68
2007 Kozikowski AP, Chellappan SK, Henderson D, Fulton R, Giboureau N, Xiao Y, Wei ZL, Guilloteau D, Emond P, Dolle F, Kellar KJ, Kassiou M. Acetylenic pyridines for use in PET imaging of nicotinic receptors. Chemmedchem. 2: 54-7. PMID 17096450 DOI: 10.1002/cmdc.200600220  0.68
2006 Kozikowski AP, Roth B, Tropsha A. Why academic drug discovery makes sense. Science (New York, N.Y.). 313: 1235-6. PMID 16946051 DOI: 10.1126/science.313.5791.1235c  0.68
2006 Jayaprakash S, Iso Y, Wan B, Franzblau SG, Kozikowski AP. Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents Chemmedchem. 1: 593-597. PMID 16892398 DOI: 10.1002/cmdc.200600010  0.68
2006 Mach UR, Lewin NE, Blumberg PM, Kozikowski AP. Synthesis and pharmacological evaluation of 8- and 9-substituted benzolactam-V8 derivatives as potent ligands for protein kinase C, a therapeutic target for Alzheimer's disease Chemmedchem. 1: 307-314. PMID 16892365 DOI: 10.1002/cmdc.200500068  0.68
2006 Jayaprakash S, Wang X, Heston WD, Kozikowski AP. Design and synthesis of a PSMA inhibitor-doxorubicin conjugate for targeted prostate cancer therapy Chemmedchem. 1: 299-302. PMID 16892363 DOI: 10.1002/cmdc.200500044  0.68
2006 Kozikowski AP, Gaisina IN, Petukhov PA, Sridhar J, King LT, Blond SY, Duka T, Rusnak M, Sidhu A. Highly potent and specific GSK-3β inhibitors that block tau phosphorylation and decrease α-synuclein protein expression in a cellular model of Parkinson's disease Chemmedchem. 1: 256-266. PMID 16892358 DOI: 10.1002/cmdc.200500039  0.68
2006 Kozikowski AP, Zhao L, Zhang A, Wang CZ, Flippen-Anderson J, Johnson KM. Structural remodeling of cocaine: design and synthesis of trisubstituted cyclopropanes as selective serotonin reuptake inhibitors. Chemmedchem. 1: 58-65. PMID 16892336 DOI: 10.1002/cmdc.200500016  0.68
2006 Xiao Y, Fan H, Musachio JL, Wei ZL, Chellappan SK, Kozikowski AP, Kellar KJ. Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them. Molecular Pharmacology. 70: 1454-60. PMID 16857741 DOI: 10.1124/mol.106.027318  0.68
2006 Micale N, Kozikowski AP, Ettari R, Grasso S, Zappalà M, Jeong JJ, Kumar A, Hanspal M, Chishti AH. Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents Journal of Medicinal Chemistry. 49: 3064-3067. PMID 16722625 DOI: 10.1021/jm060405f  0.68
2006 Chellappan SK, Xiao Y, Tueckmantel W, Kellar KJ, Kozikowski AP. Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. Journal of Medicinal Chemistry. 49: 2673-6. PMID 16640326 DOI: 10.1021/jm051196m  0.68
2006 Musachio JL, Hong J, Ichise M, Seneca N, Brown AK, Liow JS, Halldin C, Innis RB, Pike VW, He R, Zhou J, Kozikowski AP. Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 3101-4. PMID 16621532 DOI: 10.1016/j.bmcl.2006.03.066  0.68
2006 Zhong C, Zhao X, Van KC, Bzdega T, Smyth A, Zhou J, Kozikowski AP, Jiang J, O'Connor WT, Berman RF, Neale JH, Lyeth BG. NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat. Journal of Neurochemistry. 97: 1015-25. PMID 16606367 DOI: 10.1111/j.1471-4159.2006.03786.x  0.68
2006 Gills JJ, Holbeck S, Hollingshead M, Hewitt SM, Kozikowski AP, Dennis PA. Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt Molecular Cancer Therapeutics. 5: 713-722. PMID 16546986 DOI: 10.1158/1535-7163.MCT-05-0484  0.68
2006 Iso Y, Grajkowska E, Wroblewski JT, Davis J, Goeders NE, Johnson KM, Sanker S, Roth BL, Tueckmantel W, Kozikowski AP. Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications. Journal of Medicinal Chemistry. 49: 1080-100. PMID 16451073 DOI: 10.1021/jm050570f  0.68
2006 Makarewicz D, Gadamski R, Ziembowicz A, Kozikowski AP, Wroblewski JT, Lazarewicz JW. Neuroprotective effects of the agonist of metabotropic glutamate receptors ABHxD-I in two animal models of cerebral ischaemia. Resuscitation. 68: 119-26. PMID 16325990 DOI: 10.1016/j.resuscitation.2005.05.018  0.68
2006 Wee S, Wang Z, He R, Zhou J, Kozikowski AP, Woolverton WL. Role of the increased noradrenergic neurotransmission in drug self-administration. Drug and Alcohol Dependence. 82: 151-7. PMID 16213110 DOI: 10.1016/j.drugalcdep.2005.09.002  0.68
2006 Iso Y, Kozikowski AP. Synthesis of 4-arylethynyl-2-methyloxazole derivatives as mGluR5 antagonists for use in the treatment of drug abuse Synthesis. 243-246. DOI: 10.1055/s-2005-918503  0.68
2005 Zhou J, Neale JH, Pomper MG, Kozikowski AP. NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nature Reviews. Drug Discovery. 4: 1015-26. PMID 16341066 DOI: 10.1038/nrd1903  0.68
2005 He R, Kurome T, Giberson KM, Johnson KM, Kozikowski AP. Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors. Journal of Medicinal Chemistry. 48: 7970-9. PMID 16335921 DOI: 10.1021/jm050694s  0.68
2005 Yu M, Tueckmantel W, Wang X, Zhu A, Kozikowski AP, Brownell AL. Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: Synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors Nuclear Medicine and Biology. 32: 631-640. PMID 16026710 DOI: 10.1016/j.nucmedbio.2005.05.004  0.68
2005 Guilarte TR, McGlothan JL, Foss CA, Zhou J, Heston WD, Kozikowski AP, Pomper MG. Glutamate carboxypeptidase II levels in rodent brain using [125I]DCIT quantitative autoradiography. Neuroscience Letters. 387: 141-4. PMID 16006038 DOI: 10.1016/j.neulet.2005.06.015  0.68
2005 Foss CA, Mease RC, Fan H, Wang Y, Ravert HT, Dannals RF, Olszewski RT, Heston WD, Kozikowski AP, Pomper MG. Radiolabeled small-molecule ligands for prostate-specific membrane antigen: in vivo imaging in experimental models of prostate cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 4022-8. PMID 15930336 DOI: 10.1158/1078-0432.CCR-04-2690  0.68
2005 Ukairo OT, Bondi CD, Newman AH, Kulkarni SS, Kozikowski AP, Pan S, Surratt CK. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue Journal of Pharmacology and Experimental Therapeutics. 314: 575-583. PMID 15879005 DOI: 10.1124/jpet.105.085829  0.68
2005 Yin Y, Russell RG, Dettin LE, Bai R, Wei ZL, Kozikowski AP, Kopelovich L, Kopleovich L, Glazer RI. Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis. Cancer Research. 65: 3950-7. PMID 15867396 DOI: 10.1158/0008-5472.CAN-04-3990  0.68
2005 Zhou J, Kläss T, Johnson KM, Giberson KM, Kozikowski AP. Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants. Bioorganic & Medicinal Chemistry Letters. 15: 2461-5. PMID 15863297 DOI: 10.1016/j.bmcl.2005.03.083  0.68
2005 Jung M, Velena A, Chen B, Petukhov PA, Kozikowski AP, Dritschilo A. Novel HDAC inhibitors with radiosensitizing properties Radiation Research. 163: 488-493. PMID 15850409 DOI: 10.1667/RR3345  0.68
2005 Wei ZL, Xiao Y, Yuan H, Baydyuk M, Petukhov PA, Musachio JL, Kellar KJ, Kozikowski AP. Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. Journal of Medicinal Chemistry. 48: 1721-4. PMID 15771418 DOI: 10.1021/jm0492406  0.68
2005 Carón RW, Yacoub A, Li M, Zhu X, Mitchell C, Hong Y, Hawkins W, Sasazuki T, Shirasawa S, Kozikowski AP, Dennis PA, Hagan MP, Grant S, Dent P. Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. Molecular Cancer Therapeutics. 4: 257-70. PMID 15713897  0.68
2005 Chen B, Petukhov PA, Jung M, Velena A, Eliseeva E, Dritschilo A, Kozikowski AP. Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors Bioorganic and Medicinal Chemistry Letters. 15: 1389-1392. PMID 15713393 DOI: 10.1016/j.bmcl.2005.01.006  0.68
2004 Wei ZL, Petukhov PA, Bizik F, Teixeira JC, Mercola M, Volpe EA, Glazer RI, Willson TM, Kozikowski AP. Isoxazolyl-serine-based agonists of peroxisome proliferator-activated receptor: design, synthesis, and effects on cardiomyocyte differentiation. Journal of the American Chemical Society. 126: 16714-5. PMID 15612696 DOI: 10.1021/ja046386l  0.68
2004 Micale N, Vairagoundar R, Yakovlev AG, Kozikowski AP. Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3 Journal of Medicinal Chemistry. 47: 6455-6458. PMID 15588079 DOI: 10.1021/jm049248f  0.68
2004 Yuan H, Kozikowski AP, Petukhov PA. CoMFA study of piperidine analogues of cocaine at the dopamine transporter: Exploring the binding mode of the 3α-substituent of the piperidine ring using pharmacophore-based flexible alignment Journal of Medicinal Chemistry. 47: 6137-6143. PMID 15566285 DOI: 10.1021/jm049544s  0.68
2004 Zhou J, He R, Johnson KM, Ye Y, Kozikowski AP. Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization. Journal of Medicinal Chemistry. 47: 5821-4. PMID 15537337 DOI: 10.1021/jm040117o  0.68
2004 Pearce LV, Petukhov PA, Szabo T, Kedei N, Bizik F, Kozikowski AP, Blumberg PM. Evodiamine functions as an agonist for the vanilloid receptor TRPV1 Organic and Biomolecular Chemistry. 2: 2281-2286. PMID 15305207 DOI: 10.1039/b404506h  0.68
2004 Etcheberrigaray R, Tan M, Dewachter I, Kuipéri C, Van der Auwera I, Wera S, Qiao L, Bank B, Nelson TJ, Kozikowski AP, Van Leuven F, Alkon DL. Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 11141-6. PMID 15263077 DOI: 10.1073/pnas.0403921101  0.68
2004 Petukhov PA, Zhang J, Wang CZ, Ye YP, Johnson KM, Kozikowski AP. Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring. Journal of Medicinal Chemistry. 47: 3009-18. PMID 15163183 DOI: 10.1021/jm0303296  0.68
2004 Olszewski RT, Bukhari N, Zhou J, Kozikowski AP, Wroblewski JT, Shamimi-Noori S, Wroblewska B, Bzdega T, Vicini S, Barton FB, Neale JH. NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. Journal of Neurochemistry. 89: 876-85. PMID 15140187 DOI: 10.1111/j.1471-4159.2004.02358.x  0.68
2004 Castillo SS, Brognard J, Petukhov PA, Zhang C, Tsurutani J, Granville CA, Li M, Jung M, West KA, Gills JG, Kozikowski AP, Dennis PA. Preferential Inhibition of Akt and Killing of Akt-Dependent Cancer Cells by Rationally Designed Phosphatidylinositol Ether Lipid Analogues Cancer Research. 64: 2782-2792. PMID 15087394 DOI: 10.1158/0008-5472.CAN-03-1530  0.68
2004 Wei ZL, Xiao Y, Kellar KJ, Kozikowski AP. Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors. Bioorganic & Medicinal Chemistry Letters. 14: 1855-8. PMID 15050615 DOI: 10.1016/j.bmcl.2003.10.071  0.68
2004 Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH. Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. Journal of Medicinal Chemistry. 47: 1729-38. PMID 15027864 DOI: 10.1021/jm0306226  0.68
2004 Quirante J, Vila X, Bonjoch J, Kozikowski AP, Johnson KM. 2,3-disubstituted 6-azabicyclo[3.2.1]octanes as novel dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry. 12: 1383-91. PMID 15018911 DOI: 10.1016/j.bmc.2004.01.019  0.68
2004 Komander D, Kular GS, Schüttelkopf AW, Deak M, Prakash KRC, Bain J, Elliott M, Garrido-Franco M, Kozikowski AP, Alessi DR, Van Aalten DMF. Interactions of LY333531 and Other Bisindolyl Maleimide Inhibitors with PDK1 Structure. 12: 215-226. PMID 14962382 DOI: 10.1016/S0969-2126(04)00007-3  0.68
2004 Tóth A, Blumberg PM, Chen Z, Kozikowski AP. Design of a High-Affinity Competitive Antagonist of the Vanilloid Receptor Selective for the Calcium Entry-Linked Receptor Population Molecular Pharmacology. 65: 282-291. PMID 14742669 DOI: 10.1124/mol.65.2.282  0.68
2004 Pellecchia M, Kozikowski AP. Preface Current Pharmaceutical Design. 10: xxx.  0.68
2003 Wei ZL, Xiao Y, George C, Kellar KJ, Kozikowski AP. Functionalization of the alicyclic skeleton of epibatidine: synthesis and nicotinic acetylcholine receptor binding affinities of epibatidine analogues. Organic & Biomolecular Chemistry. 1: 3878-81. PMID 14664377 DOI: 10.1039/b308906a  0.68
2003 Wei ZL, Kozikowski AP. A Short and Efficient Synthesis of the Pharmacological Research Tool GW501516 for the Peroxisome Proliferator-Activated Receptor δ Journal of Organic Chemistry. 68: 9116-9118. PMID 14604391 DOI: 10.1021/jo035140g  0.68
2003 Zhou J, Kläss T, Zhang A, Johnson KM, Wang CZ, Ye Y, Kozikowski AP. Synthesis and pharmacological evaluation of (Z)-9-(heteroarylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes: thiophene analogues as potent norepinephrine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 3565-9. PMID 14505672 DOI: 10.1016/S0960-894X(03)00786-8  0.68
2003 Sridhar J, Wei ZL, Nowak I, Lewin NE, Ayres JA, Pearce LV, Blumberg PM, Kozikowski AP. New bivalent PKC ligands linked by a carbon spacer: Enhancement in binding affinity Journal of Medicinal Chemistry. 46: 4196-4204. PMID 12954072 DOI: 10.1021/jm0302041  0.68
2003 Zhou J, Zhang A, Kläss T, Johnson KM, Wang CZ, Ye YP, Kozikowski AP. Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites. Journal of Medicinal Chemistry. 46: 1997-2007. PMID 12723962 DOI: 10.1021/jm020596w  0.68
2003 Meuillet EJ, Mahadevan D, Vankayalapati H, Berggren M, Williams R, Coon A, Kozikowski AP, Powis G. Specific inhibition of the Akt1 pleckstrin homology domain by D-3-deoxy-phosphatidyl-myo-inositol analogues. Molecular Cancer Therapeutics. 2: 389-99. PMID 12700283  0.68
2003 Kozikowski AP, Johnson KM, Deschaux O, Bandyopadhyay BC, Araldi GL, Carmona G, Munzar P, Smith MP, Balster RL, Beardsley PM, Tella SR. Mixed cocaine agonist/antagonist properties of (+)-methyl 4beta-(4-chlorophenyl)-1-methylpiperidine-3alpha-carboxylate, a piperidine-based analog of cocaine. The Journal of Pharmacology and Experimental Therapeutics. 305: 143-50. PMID 12649362 DOI: 10.1124/jpet.102.046318  0.68
2003 Faden AI, Fox GB, Di X, Knoblach SM, Cernak I, Mullins P, Nikolaeva M, Kozikowski AP. Neuroprotective and nootropic actions of a novel cyclized dipeptide after controlled cortical impact injury in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 23: 355-63. PMID 12621310  0.68
2003 Faden AI, Knoblach SM, Cernak I, Fan L, Vink R, Araldi GL, Fricke ST, Roth BL, Kozikowski AP. Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 23: 342-54. PMID 12621309  0.68
2003 Wei ZL, Petukhov PA, Xiao Y, Tückmantel W, George C, Kellar KJ, Kozikowski AP. Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues. Journal of Medicinal Chemistry. 46: 921-4. PMID 12620069 DOI: 10.1021/jm025613w  0.68
2003 Sakamuri S, Enyedy IJ, Zaman WA, Tella SR, Kozikowski AP, Flippen-Anderson JL, Farkas T, Johnson KM, Wang S. 2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry. 11: 1123-36. PMID 12614900 DOI: 10.1016/S0968-0896(02)00450-9  0.68
2003 Kozikowski AP, Tückmantel W, Böttcher G, Romanczyk LJ. Studies in polyphenol chemistry and bioactivity. 4. Synthesis of trimeric, tetrameric, pentameric, and higher oligomeric epicatechin-derived procyanidins having all-4β,8-interflavan connectivity and their inhibition of cancer cell growth through cell cycle arrest Journal of Organic Chemistry. 68: 1641-1658. PMID 12608775 DOI: 10.1021/jo020393f  0.68
2003 Kozikowski AP, Sun H, Brognard J, Dennis PA. Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt Journal of the American Chemical Society. 125: 1144-1145. PMID 12553797 DOI: 10.1021/ja0285159  0.68
2003 Kozikowski AP, Nowak I, Petukhov PA, Etcheberrigaray R, Mohamed A, Tan M, Lewin N, Hennings H, Pearce LL, Blumberg PM. New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα Journal of Medicinal Chemistry. 46: 364-373. PMID 12540236 DOI: 10.1021/jm020350r  0.68
2003 Wei ZL, George C, Kozikowski AP. Synthesis of 5-endo-, 5-exo-, 6-endo- and 6-exo-hydroxylated analogues of epibatidine Tetrahedron Letters. 44: 3847-3850. DOI: 10.1016/S0040-4039(03)00737-8  0.68
2002 Pomper MG, Musachio JL, Zhang J, Scheffel U, Zhou Y, Hilton J, Maini A, Dannals RF, Wong DF, Kozikowski AP. 11C-MCG: Synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase) Molecular Imaging. 1: 96-101. PMID 12920850 DOI: 10.1162/153535002320162750  0.68
2002 Riedel G, Harrington NR, Kozikowski AP, Sandager-Nielsen K, Macphail EM. Variation of CS salience reveals group II mGluR-dependent and -independent forms of conditioning in the rat. Neuropharmacology. 43: 205-14. PMID 12213274 DOI: 10.1016/S0028-3908(02)00096-5  0.68
2002 Rong SB, Zhang J, Neale JH, Wroblewski JT, Wang S, Kozikowski AP. Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors. Journal of Medicinal Chemistry. 45: 4140-52. PMID 12213057 DOI: 10.1021/jm010561g  0.68
2002 Prakash KR, Tang Y, Kozikowski AP, Flippen-Anderson JL, Knoblach SM, Faden AI. Synthesis and biological activity of novel neuroprotective diketopiperazines. Bioorganic & Medicinal Chemistry. 10: 3043-8. PMID 12110327 DOI: 10.1016/S0968-0896(02)00132-3  0.68
2002 Petukhov PA, Zhang J, Kozikowski AP, Wang CZ, Ye YP, Johnson KM, Tella SR. SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement. Journal of Medicinal Chemistry. 45: 3161-70. PMID 12109901 DOI: 10.1021/jm0200153  0.68
2002 Ma D, Tang G, Kozikowski AP. Synthesis of 7-substituted benzolactam-V8s and their selectivity for protein kinase C isozymes Organic Letters. 4: 2377-2380. PMID 12098251 DOI: 10.1021/ol026125l  0.68
2002 Wei ZL, Sakamuri S, Petukhov PA, George C, Lewin NE, Blumberg PM, Kozikowski AP. Synthesis and modeling study of (2S,5R,6R)- and (2S,5R,6S)-6-Hydroxy-8-(1-decynyl)-benzolactam-V8 as protein kinase C modulators Organic Letters. 4: 2169-2172. PMID 12074659 DOI: 10.1021/ol026013u  0.68
2002 Rajendran V, Saxena A, Doctor BP, Kozikowski AP. Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B Bioorganic and Medicinal Chemistry Letters. 12: 1521-1523. PMID 12031333 DOI: 10.1016/S0960-894X(02)00204-4  0.68
2002 Zhang A, Zhou G, Hoepping A, Mukhopadhyaya J, Johnson KM, Zhang M, Kozikowski AP. Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors. Journal of Medicinal Chemistry. 45: 1930-41. PMID 11960503 DOI: 10.1021/jm0105373  0.68
2002 Zhang A, Zhou G, Rong SB, Johnson KM, Zhang M, Kozikowski AP. Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors. Bioorganic & Medicinal Chemistry Letters. 12: 993-5. PMID 11909701 DOI: 10.1016/S0960-894X(02)00103-8  0.68
2002 Rong SB, Enyedy IJ, Qiao L, Zhao L, Ma D, Pearce LL, Lorenzo PS, Stone JC, Blumberg PM, Wang S, Kozikowski AP. Structural basis of RasGRP binding to high-affinity PKC ligands. Journal of Medicinal Chemistry. 45: 853-60. PMID 11831896 DOI: 10.1021/jm010422z  0.68
2002 Sun H, Bapu Reddy G, George C, Meuillet EJ, Berggren M, Powis G, Kozikowski AP. Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues Tetrahedron Letters. 43: 2835-2838. DOI: 10.1016/S0040-4039(02)00354-4  0.68
2001 Maaser K, Höpfner M, Jansen A, Weisinger G, Gavish M, Kozikowski AP, Weizman A, Carayon P, Riecken EO, Zeitz M, Scherübl H. Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. British Journal of Cancer. 85: 1771-80. PMID 11742501 DOI: 10.1054/bjoc.2001.2181  0.68
2001 Zhang J, Flippen-Anderson JL, Kozikowski AP. A tandem Michael addition ring-closure route to the metabotropic receptor ligand α-(hydroxymethyl)glutamic acid and its γ-alkylated derivatives Journal of Organic Chemistry. 66: 7555-7559. PMID 11681981 DOI: 10.1021/jo010626n  0.68
2001 Petukhov PA, Zhang M, Johnson KJ, Tella SR, Kozikowski AP. SAR studies of piperidine-based analogues of cocaine. Part 3: Oxadiazoles Bioorganic and Medicinal Chemistry Letters. 11: 2079-2083. PMID 11514143 DOI: 10.1016/S0960-894X(01)00379-1  0.68
2001 Mukhopadhyaya JK, Kozikowski AP, Grajkowska E, Pshenichkin S, Wroblewski JT. Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors. Bioorganic & Medicinal Chemistry Letters. 11: 1919-24. PMID 11459661 DOI: 10.1016/S0960-894X(01)00329-8  0.68
2001 Wang S, Sakamuri S, Enyedy IJ, Kozikowski AP, Zaman WA, Johnson KM. Molecular modeling, structure--activity relationships and functional antagonism studies of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketones as a novel class of dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry. 9: 1753-64. PMID 11425577 DOI: 10.1016/S0968-0896(01)00090-6  0.68
2001 Enyedy IJ, Zaman WA, Sakamuri S, Kozikowski AP, Johnson KM, Wang S. Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. 11: 1113-8. PMID 11354356 DOI: 10.1016/S0960-894X(01)00132-9  0.68
2001 Tamiz AP, Bandyopadhyay BC, Zhang J, Flippen-Anderson JL, Zhang M, Wang CZ, Johnson KM, Tella S, Kozikowski AP. Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors. Journal of Medicinal Chemistry. 44: 1615-22. PMID 11334571 DOI: 10.1021/jm000552s  0.68
2001 Qiao L, Zhao LY, Rong SB, Wu XW, Wang S, Fujii T, Kazanietz MG, Rauser L, Savage J, Roth BL, Flippen-Anderson J, Kozikowski AP. Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth. Bioorganic & Medicinal Chemistry Letters. 11: 955-9. PMID 11327599 DOI: 10.1016/S0960-894X(01)00097-X  0.68
2001 Kozikowski AP, Tückmantel W, Hu Y. Studies in polyphenol chemistry and bioactivity. 3. Stereocontrolled synthesis of epicatechin-4α,8-epicatechin, an unnatural isomer of the B-type procyanidins Journal of Organic Chemistry. 66: 1287-1296. PMID 11312959 DOI: 10.1021/jo001462y  0.68
2001 Rong SB, Hu Y, Enyedy I, Powis G, Meuillet EJ, Wu X, Wang R, Wang S, Kozikowski AP. Molecular modeling studies of the Akt PH domain and its interaction with phosphoinositides. Journal of Medicinal Chemistry. 44: 898-908. PMID 11300871 DOI: 10.1021/jm000493i  0.68
2001 TrzciÅ„ska M, Pimentel P, Stellar JR, Hanson RN, Choi SW, Elmaleh DR, Zhang J, Prakash KR, Tamiz AP, Kozikowski AP, Johnson KM, Smith MP, Babich JW. Novel monoamine transporter ligands reduce cocaine-induced enhancement of brain stimulation reward. Pharmacology, Biochemistry, and Behavior. 68: 171-80. PMID 11274722 DOI: 10.1016/S0091-3057(00)00454-8  0.68
2001 Sakamuri S, Enyedy IJ, Kozikowski AP, Zaman WA, Johnson KM, Wang S. Pharmacophore-based discovery, synthesis, and biological evaluation of 4-phenyl-1-arylalkyl piperidines as dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. 11: 495-500. PMID 11229756 DOI: 10.1016/S0960-894X(00)00703-4  0.68
2001 Rajendran V, Rong SB, Saxena A, Doctor BP, Kozikowski AP. Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B Tetrahedron Letters. 42: 5359-5361. DOI: 10.1016/S0040-4039(01)01008-5  0.68
2001 Sakamuri S, Kozikowski AP. Synthesis of 7-methoxybenzolactam-V8 using a diastereoselective Strecker synthesis Chemical Communications. 475-476.  0.68
1999 Kozikowski AP, Simoni D, Roberti M, Rondanin R, Wang S, Du P, Johnson KM. Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity. Bioorganic & Medicinal Chemistry Letters. 9: 1831-6. PMID 10406650 DOI: 10.1016/S0960-894X(99)00273-5  0.68
1992 Kozikowski AP, Roberti M, Xiang L, Bergmann JS, Callahan PM, Cunningham KA, Johnson KM. Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue. Journal of Medicinal Chemistry. 35: 4764-6. PMID 1469704  0.68
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