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Alan P. Kozikowski - Publications

Affiliations: 
University of Illinois at Chicago, Chicago, IL, United States 
Area:
medicinal chemistry
Website:
http://foto.pharm.uic.edu/mcp/people/kozikowski_ap.html

119 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Huang J, Wang L, Dahiya S, Beier UH, Han R, Samanta A, Bergman J, Sotomayor EM, Seto E, Kozikowski AP, Hancock WW. Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Scientific Reports. 7: 8626. PMID 28819166 DOI: 10.1038/S41598-017-09211-3  0.317
2017 Ugolkov A, Qiang W, Bondarenko G, Procissi D, Gaisina I, James CD, Chandler J, Kozikowski A, Gunosewoyo H, O'Halloran T, Raizer J, Mazar AP. Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models. Translational Oncology. 10: 669-678. PMID 28672195 DOI: 10.1016/J.Tranon.2017.06.003  0.319
2017 Zhang G, Cheng J, McCorvy JD, Lorello PJ, Caldarone BJ, Roth BL, Kozikowski AP. Discovery of N-Substituted 2-Phenylcyclopropylmethylamines as Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists for Potential Use as Antipsychotic Medications. Journal of Medicinal Chemistry. PMID 28657744 DOI: 10.1021/Acs.Jmedchem.7B00584  0.347
2017 Pogorelov VM, Rodriguiz RM, Cheng J, Huang M, Schmerberg CM, Meltzer HY, Roth BL, Kozikowski AP, Wetsel WC. 5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28294132 DOI: 10.1038/Npp.2017.52  0.308
2017 Budke B, Lv W, Tueckmantel W, Kozikowski A, Connell P. Abstract PR02: Small molecules that specifically inhibit the D-loop activity of RAD51 Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-Pr02  0.364
2017 Kim J, Nair JR, Hadley MM, Kozikowski A, Miller R, Villagra A. Abstract LB-295: A novel regulatory role of HDAC6 in the functional inflammatory phenotype of glia cells Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-295  0.307
2017 Hadley M, Shen S, Banik D, Kim J, Nair J, Knox T, Gallub V, Kirkland S, Chiappinelli KB, Sotomayor E, Kozikowski A, Villagra A. Abstract LB-294:In vivoevaluation of Ames negative HDAC6 inhibitor in melanoma model Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-294  0.369
2016 Cheng J, McCorvy JD, Giguère PM, Zhu H, Kenakin T, Roth BL, Kozikowski AP. Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists. Journal of Medicinal Chemistry. PMID 27726356 DOI: 10.1021/Acs.Jmedchem.6B01194  0.319
2016 Zhang HK, Eaton JB, Fedolak A, Gunosewoyo H, Onajole OK, Brunner D, Lukas RJ, Yu LF, Kozikowski AP. Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists. European Journal of Medicinal Chemistry. 124: 689-697. PMID 27639361 DOI: 10.1016/J.Ejmech.2016.09.016  0.346
2016 Stec J, Onajole OK, Lun S, Guo H, Merenbloom B, Vistoli G, Bishai WR, Kozikowski AP. Indole-2-carboxamide-Based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection. Journal of Medicinal Chemistry. PMID 27275668 DOI: 10.1021/Acs.Jmedchem.6B00415  0.318
2016 Lv W, Budke B, Pawlowski M, Connell PP, Kozikowski AP. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. Journal of Medicinal Chemistry. PMID 27049177 DOI: 10.1016/J.Ijrobp.2016.06.053  0.324
2016 Onajole OK, Vallerini GP, Eaton JB, Lukas RJ, Brunner D, Caldarone BJ, Kozikowski AP. Synthesis and Behavioral Studies of Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile. Part III. Acs Chemical Neuroscience. PMID 27035276 DOI: 10.1021/Acschemneuro.6B00050  0.361
2016 Wang Z, Leng Y, Wang J, Liao HM, Bergman J, Leeds P, Kozikowski A, Chuang DM. Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation. Scientific Reports. 6: 19626. PMID 26790818 DOI: 10.1038/Srep19626  0.31
2016 Lienlaf M, Perez-Villarroel P, Knox T, Pabon M, Sahakian E, Powers J, Woan KV, Lee C, Cheng F, Deng S, Smalley KS, Montecino M, Kozikowski A, Pinilla-Ibarz J, Sarnaik A, et al. Essential role of HDAC6 in the regulation of PD-L1 in melanoma. Molecular Oncology. PMID 26775640 DOI: 10.1016/J.Molonc.2015.12.012  0.326
2015 Cheng J, Giguère PM, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Huang XP, Zhu H, McCorvy JD, Wetsel WC, Roth BL, Kozikowski AP. Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models. Journal of Medicinal Chemistry. PMID 26704965 DOI: 10.1021/Acs.Jmedchem.5B01153  0.333
2015 Lu S, Zhang Y, Kalin JH, Cai L, Kozikowski AP, Pike VW. Exploration of the labeling of [(11) C]tubastatin A at the hydroxamic acid site with [(11) C]carbon monoxide. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 26647018 DOI: 10.1002/Jlcr.3360  0.598
2015 Segretti MC, Vallerini GP, Brochier C, Langley B, Wang L, Hancock WW, Kozikowski AP. Thiol-Based Potent and Selective HDAC6 Inhibitors Promote Tubulin Acetylation and T-Regulatory Cell Suppressive Function. Acs Medicinal Chemistry Letters. 6: 1156-1161. PMID 26617971 DOI: 10.1021/Acsmedchemlett.5B00303  0.382
2015 Shen S, Kozikowski AP. Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors-What Some May Have Forgotten or Would Rather Forget? Chemmedchem. PMID 26603496 DOI: 10.1002/Cmdc.201500486  0.365
2015 Shen S, Benoy V, Bergman JA, Kalin JH, Frojuello M, Vistoli G, Haeck W, Van Den Bosch L, Kozikowski AP. Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease. Acs Chemical Neuroscience. PMID 26599234 DOI: 10.1021/Acschemneuro.5B00286  0.661
2015 Gaisina IN, Tueckmantel W, Ugolkov A, Shen S, Hoffen J, Dubrovskyi O, Mazar A, Schoon RA, Billadeau D, Kozikowski AP. Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity. Chemmedchem. PMID 26592932 DOI: 10.1002/Cmdc.201500456  0.38
2015 Cheng J, Giguere PM, Lv W, Roth BL, Kozikowski AP. Design and Synthesis of (2-(5-Chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a Selective Serotonin 2C Agonist. Tetrahedron Letters. 56: 3420-3422. PMID 26120215 DOI: 10.1016/J.Tetlet.2015.01.060  0.334
2015 Woan KV, Lienlaf M, Perez-Villaroel P, Lee C, Cheng F, Knox T, Woods DM, Barrios K, Powers J, Sahakian E, Wang HW, Canales J, Marante D, Smalley KS, Bergman J, ... ... Kozikowski A, et al. Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation. Molecular Oncology. PMID 25957812 DOI: 10.1016/J.Molonc.2015.04.002  0.34
2015 Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP. Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents. Journal of Medicinal Chemistry. 58: 1992-2002. PMID 25633969 DOI: 10.1021/Jm5019274  0.343
2015 Dubrovskyi O, Ugolkov A, Gaisina I, Bondarenko G, Strizzi L, Margaryan N, O'Halloran T, Kozikowski A, Hendrix M, Mazar A. Abstract 3287: Targeting GSK-3: a new approach for the treatment of neuroblastoma Cancer Research. 75: 3287-3287. DOI: 10.1158/1538-7445.Am2015-3287  0.351
2015 Ugolkov A, Dubrovskyi O, Gaisina I, Yemelyanov A, Bondarenko G, James C, Chandler J, O'Halloran T, Kozikowski A, Raizer J, Mazar A. Abstract 2699: Targeting GSK-3: a novel approach to enhance glioblastoma chemosensitivity Cancer Research. 75: 2699-2699. DOI: 10.1158/1538-7445.Am2015-2699  0.318
2015 Ugolkov A, Bondarenko G, Gaisina I, Dubrovskyi O, Yemelyanov A, James C, Chandler J, O'Halloran T, Kozikowski A, Raizer J, Mazar A. ATPS-91GSK-3 INHIBITOR 9-ING-41 ENHANCES GENOTOXIC THERAPY OF GBM LEADING TO CURE FROM INTRACRANIAL BRAIN TUMOR Neuro-Oncology. 17: v38.3-v38. DOI: 10.1093/Neuonc/Nov204.91  0.306
2014 Yu LF, Brek Eaton J, Zhang HK, Sabath E, Hanania T, Li GN, van Breemen RB, Whiteaker P, Liu Q, Wu J, Chang YC, Lukas RJ, Brunner D, Kozikowski AP. The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile. Pharmacology Research & Perspectives. 2: e00026. PMID 25505580 DOI: 10.1002/Prp2.26  0.302
2014 Onajole OK, Eaton JB, Lukas RJ, Brunner D, Thiede L, Caldarone BJ, Kozikowski AP. Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4β2-nAChR Ligands. Acs Medicinal Chemistry Letters. 5: 1196-201. PMID 25408831 DOI: 10.1021/Ml500129K  0.313
2014 Stec J, Vilchèze C, Lun S, Perryman AL, Wang X, Freundlich JS, Bishai W, Jacobs WR, Kozikowski AP. Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis. Chemmedchem. 9: 2528-37. PMID 25165007 DOI: 10.1002/Cmdc.201402255  0.352
2014 Cheng F, Lienlaf M, Wang HW, Perez-Villarroel P, Lee C, Woan K, Rock-Klotz J, Sahakian E, Woods D, Pinilla-Ibarz J, Kalin J, Tao J, Hancock W, Kozikowski A, Seto E, et al. A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs. Journal of Immunology (Baltimore, Md. : 1950). 193: 2850-62. PMID 25108026 DOI: 10.4049/Jimmunol.1302778  0.627
2014 Mason JM, Logan HL, Budke B, Wu M, Pawlowski M, Weichselbaum RR, Kozikowski AP, Bishop DK, Connell PP. The rad51-stimulatory compound rs-1 can exploit the rad51 overexpression that exists in cancer cells and tumors Cancer Research. 74: 3546-3555. PMID 24753542 DOI: 10.1158/0008-5472.Can-13-3220  0.309
2014 Xu X, Kozikowski AP, Pozzo-Miller L. A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome. Frontiers in Cellular Neuroscience. 8: 68. PMID 24639629 DOI: 10.3389/Fncel.2014.00068  0.307
2014 Selenica ML, Benner L, Housley SB, Manchec B, Lee DC, Nash KR, Kalin J, Bergman JA, Kozikowski A, Gordon MN, Morgan D. Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition. Alzheimer's Research & Therapy. 6: 12. PMID 24576665 DOI: 10.1186/Alzrt241  0.631
2014 Pal K, Cao Y, Gaisina IN, Bhattacharya S, Dutta SK, Wang E, Gunosewoyo H, Kozikowski AP, Billadeau DD, Mukhopadhyay D. Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer. Molecular Cancer Therapeutics. 13: 285-96. PMID 24327518 DOI: 10.1158/1535-7163.Mct-13-0681  0.307
2014 Alvarez A, Ugolkov A, Gaisina I, Kozikowski AP, Joshi K, Kim S, Nakano I, Raizer JJ, Mazar AP, Hu B, Cheng S. Abstract 1941: GSK3 signaling is critical to glioma stem cell growth and survival Cancer Research. 74: 1941-1941. DOI: 10.1158/1538-7445.Am2014-1941  0.305
2013 Stec J, Fomovska A, Afanador GA, Muench SP, Zhou Y, Lai BS, El Bissati K, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Sommervile C, Woods S, Roberts CW, Rice D, ... ... Kozikowski AP, et al. Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii. Chemmedchem. 8: 1138-60. PMID 23776166 DOI: 10.1002/Cmdc.201300050  0.363
2013 Gunosewoyo H, Midzak A, Gaisina IN, Sabath EV, Fedolak A, Hanania T, Brunner D, Papadopoulos V, Kozikowski AP. Characterization of maleimide-based glycogen synthase kinase-3 (GSK-3) inhibitors as stimulators of steroidogenesis. Journal of Medicinal Chemistry. 56: 5115-29. PMID 23725591 DOI: 10.1021/Jm400511S  0.341
2013 Gunosewoyo H, Tipparaju SK, Pieroni M, Wang Y, Doctor BP, Nambiar MP, Kozikowski AP. Structural analogs of huperzine A improve survival in guinea pigs exposed to soman. Bioorganic & Medicinal Chemistry Letters. 23: 1544-7. PMID 23395652 DOI: 10.1016/J.Bmcl.2012.11.083  0.309
2013 Budke B, Kalin JH, Pawlowski M, Zelivianskaia AS, Wu M, Kozikowski AP, Connell PP. An optimized RAD51 inhibitor that disrupts homologous recombination without requiring michael acceptor reactivity Journal of Medicinal Chemistry. 56: 254-263. PMID 23231413 DOI: 10.1021/Jm301565B  0.62
2012 Gills JJ, Zhang C, Abu-Asab MS, Castillo SS, Marceau C, LoPiccolo J, Kozikowski AP, Tsokos M, Goldkorn T, Dennis PA. Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine Cell Death and Disease. 3. PMID 22764099 DOI: 10.1038/Cddis.2012.72  0.325
2012 Budke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL, Stark JM, Kozikowski AP, Bishop DK, Connell PP. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Research. 40: 7347-57. PMID 22573178 DOI: 10.1093/Nar/Gks353  0.616
2012 Fomovska A, Huang Q, El Bissati K, Mui EJ, Witola WH, Cheng G, Zhou Y, Sommerville C, Roberts CW, Bettis S, Prigge ST, Afanador GA, Hickman MR, Lee PJ, Leed SE, ... ... Kozikowski AP, et al. Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway. Antimicrobial Agents and Chemotherapy. 56: 2666-82. PMID 22354304 DOI: 10.1128/Aac.06450-11  0.33
2012 Stec J, Huang Q, Pieroni M, Kaiser M, Fomovska A, Mui E, Witola WH, Bettis S, McLeod R, Brun R, Kozikowski AP. Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania. Journal of Medicinal Chemistry. 55: 3088-100. PMID 22352841 DOI: 10.1021/Jm2015183  0.323
2012 Kalin JH, Zhang H, Gaudrel-Grosay S, Vistoli G, Kozikowski AP. Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress Chemmedchem. 7: 425-439. PMID 22234885 DOI: 10.1002/Cmdc.201100522  0.669
2012 Kalin JH, Butler KV, Akimova T, Hancock WW, Kozikowski AP. Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells Journal of Medicinal Chemistry. 55: 639-651. PMID 22165909 DOI: 10.1021/jm200773h  0.638
2012 Cheng F, Wang Z, Wang H, Lienlaf M, Woan KV, Perez-Villarroel P, Rock-Klotz J, Sahakian E, Knox T, Woods DM, Powers J, Han R, Merino O, Deng S, Marante D, ... ... Kozikowski A, et al. Physical Interaction of Histone Deacetylase 6 (HDAC6) with STAT3 Regulates IL-10 Gene Expression and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs) Blood. 120: 829-829. DOI: 10.1182/Blood.V120.21.829.829  0.324
2012 Wang H, Cheng F, Wang Z, Lienlaf M, Perez-Villarroel P, Knox T, Sahakian E, Pinilla-Ibarz J, Horna P, Chen-Kiang S, Martin P, Bergman J, Kozikowski A, Villagra A, Tao J, et al. Inhibition of Histone Deacetylase 6 (HDAC6) Disrupts the Tolerogenic STAT3 Signaling Pathway and Augments Antitumor Immune Responses in Mantle Cell Lymphoma (MCL) Blood. 120: 3724-3724. DOI: 10.1182/Blood.V120.21.3724.3724  0.329
2012 Woan KV, Vazquez L, Rock-Klotz J, Wang Z, Cheng F, Wang H, Woods D, Sahakian E, Perez P, Lienlaf M, Achille A, Bergman J, Kalin J, Gill A, Powers J, ... ... Kozikowski AP, et al. Abstract 3555: Histone deacetylase 6 as a novel regulator of the immunogenicity and aggressiveness of melanoma Cancer Research. 72: 3555-3555. DOI: 10.1158/1538-7445.Am2012-3555  0.648
2011 Chen W, Gaisina IN, Gunosewoyo H, Malekiani SA, Hanania T, Kozikowski AP. Structure-guided design of a highly selective glycogen synthase kinase-3β inhibitor: a superior neuroprotective pyrazolone showing antimania effects. Chemmedchem. 6: 1587-92. PMID 21751402 DOI: 10.1002/Cmdc.201100231  0.318
2011 Kozikowski AP, Gunosewoyo H, Guo S, Gaisina IN, Walter RL, Ketcherside A, McClung CA, Mesecar AD, Caldarone B. Identification of a glycogen synthase kinase-3β inhibitor that attenuates hyperactivity in CLOCK mutant mice. Chemmedchem. 6: 1593-602. PMID 21732538 DOI: 10.1002/Cmdc.201100188  0.359
2011 de Zoeten EF, Wang L, Butler K, Beier UH, Akimova T, Sai H, Bradner JE, Mazitschek R, Kozikowski AP, Matthias P, Hancock WW. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3+ T-regulatory cells Molecular and Cellular Biology. 31: 2066-2078. PMID 21444725 DOI: 10.1128/Mcb.05155-11  0.332
2011 Wang H, Wang Z, Cheng F, Woan KV, Rock-Klotz J, Sahakian E, Powers J, Javier P, Bergman J, Villagra A, Kozikowski A, Sotomayor EM. Tubastatin A, a Selective HDAC6 Inhibitor, Enhances Antigen-Presenting Cell (APC) Function and Restores the Responsiveness of Anergic CD4+ T Cells Blood. 118: 520-520. DOI: 10.1182/Blood.V118.21.520.520  0.328
2011 Gills JJ, Zhang C, Abu-Asab MS, Castillo SS, Marceau C, Kozikowski A, Tsokos M, Goldkorn T, Dennis PA. Abstract 960: Ceramide-dependent release of nanovesicles is a class effect oflipid-based Akt inhibitors Cancer Research. 71: 960-960. DOI: 10.1158/1538-7445.Am2011-960  0.337
2010 Caldarone BJ, Paterson NE, Zhou J, Brunner D, Kozikowski AP, Westphal KG, Korte-Bouws GA, Prins J, Korte SM, Olivier B, Ghavami A. The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. The Journal of Pharmacology and Experimental Therapeutics. 335: 762-70. PMID 20864506 DOI: 10.1124/Jpet.110.174011  0.483
2010 Tipparaju SK, Muench SP, Mui EJ, Ruzheinikov SN, Lu JZ, Hutson SL, Kirisits MJ, Prigge ST, Roberts CW, Henriquez FL, Kozikowski AP, Rice DW, McLeod RL. Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase. Journal of Medicinal Chemistry. 53: 6287-300. PMID 20698542 DOI: 10.1021/Jm9017724  0.353
2010 Butler KV, Kalin J, Brochier C, Vistoli G, Langley B, Kozikowski AP. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A Journal of the American Chemical Society. 132: 10842-10846. PMID 20614936 DOI: 10.1021/Ja102758V  0.658
2010 Smirnova NA, Rakhman I, Moroz N, Basso M, Payappilly J, Kazakov S, Hernandez-Guzman F, Gaisina IN, Kozikowski AP, Ratan RR, Gazaryan IG. Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. Chemistry & Biology. 17: 380-91. PMID 20416509 DOI: 10.1016/J.Chembiol.2010.03.008  0.302
2010 He R, Chen Y, Ougolkov AV, Zhang JS, Savoy DN, Billadeau DD, Kozikowski AP. Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents Journal of Medicinal Chemistry. 53: 1347-1356. PMID 20055418 DOI: 10.1021/Jm901667K  0.343
2010 Lilienkampf A, Pieroni M, Wan B, Wang Y, Franzblau SG, Kozikowski AP. Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. A potent and selective series for further drug development Journal of Medicinal Chemistry. 53: 678-688. PMID 20000577 DOI: 10.1021/Jm901273N  0.337
2009 Rivieccio MA, Brochier C, Willis DE, Walker BA, D'Annibale MA, McLaughlin K, Siddiq A, Kozikowski AP, Jaffrey SR, Twiss JL, Ratan RR, Langley B. HDAC6 is a target for protection and regeneration following injury in the nervous system. Proceedings of the National Academy of Sciences of the United States of America. 106: 19599-604. PMID 19884510 DOI: 10.1073/Pnas.0907935106  0.326
2009 Guo S, Tipparaju SK, Pegan SD, Wan B, Mo S, Orjala J, Mesecar AD, Franzblau SG, Kozikowski AP. Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents. Bioorganic & Medicinal Chemistry. 17: 7126-30. PMID 19783449 DOI: 10.1016/J.Bmc.2009.08.061  0.353
2009 Butler KV, He R, McLaughlin K, Vistoli G, Langley B, Kozikowski AP. Stereoselective HDAC inhibition from cysteine-derived zinc-binding groups. Chemmedchem. 4: 1292-301. PMID 19551801 DOI: 10.1002/Cmdc.200900088  0.404
2009 Kalin JH, Butler KV, Kozikowski AP. Creating zinc monkey wrenches in the treatment of epigenetic disorders Current Opinion in Chemical Biology. 13: 263-271. PMID 19541531 DOI: 10.1016/J.Cbpa.2009.05.007  0.637
2009 Tapadar S, He R, Luchini DN, Billadeau DD, Kozikowski AP. Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity Bioorganic and Medicinal Chemistry Letters. 19: 3023-3026. PMID 19419863 DOI: 10.1016/J.Bmcl.2009.04.058  0.379
2009 Kozikowski AP, Chen Y, Subhasish T, Lewin NE, Blumberg PM, Zhong Z, D'Annibale MA, Wang WL, Shen Y, Langley B. Searching for disease modifiers - PKC activation and HDAC inhibition - A dual drug approach to Alzheimer's disease that decreases Aβ production while blocking oxidative stress Chemmedchem. 4: 1095-1105. PMID 19396896 DOI: 10.1002/Cmdc.200900045  0.357
2009 Sleiman SF, Basso M, Mahishi L, Kozikowski AP, Donohoe ME, Langley B, Ratan RR. Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions. Expert Opinion On Investigational Drugs. 18: 573-84. PMID 19388875 DOI: 10.1517/13543780902810345  0.349
2009 Gaisina IN, Gallier F, Ougolkov AV, Kim KH, Kurome T, Guo S, Holzle D, Luchini DN, Blond SY, Billadeau DD, Kozikowski AP. From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3βinhibitors that suppress proliferation and survival of pancreatic cancer cells Journal of Medicinal Chemistry. 52: 1853-1863. PMID 19338355 DOI: 10.1021/Jm801317H  0.321
2009 Chirapu SR, Pachaiyappan B, Nural HF, Cheng X, Yuan H, Lankin DC, Abdul-Hay SO, Thatcher GR, Shen Y, Kozikowski AP, Petukhov PA. Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 264-74. PMID 19013792 DOI: 10.1016/J.Bmcl.2008.10.096  0.346
2009 Cheng F, Wang H, Luetteke N, Pinilla J, Kozikowski A, Seto E, Villagra Av, Sotomayor E. A Novel Role for Histone Deacetylase 6 (HDAC6) in the Regulation of IL-10 and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs). Blood. 114: 1360-1360. DOI: 10.1182/Blood.V114.22.1360.1360  0.332
2008 Mao J, Eoh H, He R, Wang Y, Wan B, Franzblau SG, Crick DC, Kozikowski AP. Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorganic & Medicinal Chemistry Letters. 18: 5320-3. PMID 18783951 DOI: 10.1016/J.Bmcl.2008.08.034  0.331
2008 Yamamoto T, Kozikowski A, Zhou J, Neale JH. Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain. Molecular Pain. 4: 31. PMID 18673570 DOI: 10.1186/1744-8069-4-31  0.433
2008 Tipparaju SK, Mulhearn DC, Klein GM, Chen Y, Tapadar S, Bishop MH, Yang S, Chen J, Ghassemi M, Santarsiero BD, Cook JL, Johlfs M, Mesecar AD, Johnson ME, Kozikowski AP. Design and synthesis of aryl ether inhibitors of the Bacillus anthracis enoyl-ACP reductase. Chemmedchem. 3: 1250-68. PMID 18663709 DOI: 10.1002/Cmdc.200800047  0.331
2008 Dow GS, Chen Y, Andrews KT, Caridha D, Gerena L, Gettayacamin M, Johnson J, Li Q, Melendez V, Obaldia N, Tran TN, Kozikowski AP. Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors Antimicrobial Agents and Chemotherapy. 52: 3467-3477. PMID 18644969 DOI: 10.1128/Aac.00439-08  0.331
2008 Kozikowski AP, Tapadar S, Luchini DN, Ki HK, Billadeau DD. Use of the Nitrile Oxide Cycloaddition (NOC) reaction for molecular probe generation: A new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6 Journal of Medicinal Chemistry. 51: 4370-4373. PMID 18642892 DOI: 10.1021/Jm8002894  0.391
2008 Banerjee SR, Foss CA, Castanares M, Mease RC, Byun Y, Fox JJ, Hilton J, Lupold SE, Kozikowski AP, Pomper MG. Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA) Journal of Medicinal Chemistry. 51: 4504-4517. PMID 18637669 DOI: 10.1021/Jm800111U  0.302
2008 Zhang B, West EJ, Van KC, Gurkoff GG, Zhou J, Zhang XM, Kozikowski AP, Lyeth BG. HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats. Brain Research. 1226: 181-91. PMID 18582446 DOI: 10.1016/J.Brainres.2008.05.085  0.446
2008 Tipparaju SK, Joyasawal S, Forrester S, Mulhearn DC, Pegan S, Johnson ME, Mesecar AD, Kozikowski AP. Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase. Bioorganic & Medicinal Chemistry Letters. 18: 3565-9. PMID 18499454 DOI: 10.1016/J.Bmcl.2008.05.004  0.342
2008 Chen Y, Lopez-Sanchez M, Savoy DN, Billadeau DD, Dow GS, Kozikowski AP. A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum Journal of Medicinal Chemistry. 51: 3437-3448. PMID 18494463 DOI: 10.1021/Jm701606B  0.403
2008 Kozikowski AP, Chen Y, Gaysin AM, Savoy DN, Billadeau DD, Kim KH. Chemistry, biology, and QSAR studies of substituted biaryl hydroxamates and mercaptoacetamides as HDAC inhibitors - Nanomolar-potency inhibitors of pancreatic cancer cell growth Chemmedchem. 3: 487-501. PMID 18181121 DOI: 10.1002/Cmdc.200700314  0.389
2008 Olszewski RT, Wegorzewska MM, Monteiro AC, Krolikowski KA, Zhou J, Kozikowski AP, Long K, Mastropaolo J, Deutsch SI, Neale JH. Phencyclidine and Dizocilpine Induced Behaviors Reduced by N-acetylaspartylglutamate Peptidase Inhibition via Metabotropic Glutamate Receptors Biological Psychiatry. 63: 86-91. PMID 17597589 DOI: 10.1016/J.Biopsych.2007.04.016  0.45
2007 Kozikowski AP, Gaisina IN, Yuan H, Petukhov PA, Blond SY, Fedolak A, Caldarone B, McGonigle P. Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders. Journal of the American Chemical Society. 129: 8328-32. PMID 17552518 DOI: 10.1021/Ja068969W  0.318
2007 Kozikowski AP, Chen Y, Gaysin A, Chen B, D'Annibale MA, Suto CM, Langley BC. Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies. Journal of Medicinal Chemistry. 50: 3054-61. PMID 17539623 DOI: 10.1021/Jm070178X  0.352
2007 Yamamoto T, Saito O, Aoe T, Bartolozzi A, Sarva J, Zhou J, Kozikowski A, Wroblewska B, Bzdega T, Neale JH. Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. The European Journal of Neuroscience. 25: 147-58. PMID 17241276 DOI: 10.1111/J.1460-9568.2006.05272.X  0.373
2006 Kozikowski AP, Gaisina IN, Petukhov PA, Sridhar J, King LT, Blond SY, Duka T, Rusnak M, Sidhu A. Highly potent and specific GSK-3β inhibitors that block tau phosphorylation and decrease α-synuclein protein expression in a cellular model of Parkinson's disease Chemmedchem. 1: 256-266. PMID 16892358 DOI: 10.1002/Cmdc.200500039  0.324
2006 Musachio JL, Hong J, Ichise M, Seneca N, Brown AK, Liow JS, Halldin C, Innis RB, Pike VW, He R, Zhou J, Kozikowski AP. Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 3101-4. PMID 16621532 DOI: 10.1016/J.Bmcl.2006.03.066  0.452
2006 Zhong C, Zhao X, Van KC, Bzdega T, Smyth A, Zhou J, Kozikowski AP, Jiang J, O'Connor WT, Berman RF, Neale JH, Lyeth BG. NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat. Journal of Neurochemistry. 97: 1015-25. PMID 16606367 DOI: 10.1111/J.1471-4159.2006.03786.X  0.423
2006 Gills JJ, Holbeck S, Hollingshead M, Hewitt SM, Kozikowski AP, Dennis PA. Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt Molecular Cancer Therapeutics. 5: 713-722. PMID 16546986 DOI: 10.1158/1535-7163.Mct-05-0484  0.335
2006 Iso Y, Grajkowska E, Wroblewski JT, Davis J, Goeders NE, Johnson KM, Sanker S, Roth BL, Tueckmantel W, Kozikowski AP. Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications. Journal of Medicinal Chemistry. 49: 1080-100. PMID 16451073 DOI: 10.1021/Jm050570F  0.349
2006 Wee S, Wang Z, He R, Zhou J, Kozikowski AP, Woolverton WL. Role of the increased noradrenergic neurotransmission in drug self-administration. Drug and Alcohol Dependence. 82: 151-7. PMID 16213110 DOI: 10.1016/J.Drugalcdep.2005.09.002  0.42
2005 Jung M, Kozikowski A, Dritschilo A. Rational design and development of radiation-sensitizing histone deacetylase inhibitors Chemistry and Biodiversity. 2: 1452-1461. PMID 17191946 DOI: 10.1002/Cbdv.200590118  0.302
2005 Zhou J, Neale JH, Pomper MG, Kozikowski AP. NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nature Reviews. Drug Discovery. 4: 1015-26. PMID 16341066 DOI: 10.1038/Nrd1903  0.484
2005 He R, Kurome T, Giberson KM, Johnson KM, Kozikowski AP. Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors. Journal of Medicinal Chemistry. 48: 7970-9. PMID 16335921 DOI: 10.1021/Jm050694S  0.331
2005 Guilarte TR, McGlothan JL, Foss CA, Zhou J, Heston WD, Kozikowski AP, Pomper MG. Glutamate carboxypeptidase II levels in rodent brain using [125I]DCIT quantitative autoradiography. Neuroscience Letters. 387: 141-4. PMID 16006038 DOI: 10.1016/J.Neulet.2005.06.015  0.434
2005 Zhou J, Kläss T, Johnson KM, Giberson KM, Kozikowski AP. Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants. Bioorganic & Medicinal Chemistry Letters. 15: 2461-5. PMID 15863297 DOI: 10.1016/J.Bmcl.2005.03.083  0.508
2005 Jung M, Velena A, Chen B, Petukhov PA, Kozikowski AP, Dritschilo A. Novel HDAC inhibitors with radiosensitizing properties Radiation Research. 163: 488-493. PMID 15850409 DOI: 10.1667/Rr3345  0.396
2005 Chen B, Petukhov PA, Jung M, Velena A, Eliseeva E, Dritschilo A, Kozikowski AP. Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors Bioorganic and Medicinal Chemistry Letters. 15: 1389-1392. PMID 15713393 DOI: 10.1016/J.Bmcl.2005.01.006  0.393
2004 Zhou J, He R, Johnson KM, Ye Y, Kozikowski AP. Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization. Journal of Medicinal Chemistry. 47: 5821-4. PMID 15537337 DOI: 10.1021/Jm040117O  0.464
2004 Pearce LV, Petukhov PA, Szabo T, Kedei N, Bizik F, Kozikowski AP, Blumberg PM. Evodiamine functions as an agonist for the vanilloid receptor TRPV1 Organic and Biomolecular Chemistry. 2: 2281-2286. PMID 15305207 DOI: 10.1039/B404506H  0.312
2004 Yamamoto T, Hirasawa S, Wroblewska B, Grajkowska E, Zhou J, Kozikowski A, Wroblewski J, Neale JH. Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model. The European Journal of Neuroscience. 20: 483-94. PMID 15233757 DOI: 10.1111/J.1460-9568.2004.03504.X  0.439
2004 Petukhov PA, Zhang J, Wang CZ, Ye YP, Johnson KM, Kozikowski AP. Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring. Journal of Medicinal Chemistry. 47: 3009-18. PMID 15163183 DOI: 10.1021/Jm0303296  0.305
2004 Olszewski RT, Bukhari N, Zhou J, Kozikowski AP, Wroblewski JT, Shamimi-Noori S, Wroblewska B, Bzdega T, Vicini S, Barton FB, Neale JH. NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. Journal of Neurochemistry. 89: 876-85. PMID 15140187 DOI: 10.1111/J.1471-4159.2004.02358.X  0.383
2004 Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH. Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. Journal of Medicinal Chemistry. 47: 1729-38. PMID 15027864 DOI: 10.1021/Jm0306226  0.367
2003 Zhou J, Kläss T, Zhang A, Johnson KM, Wang CZ, Ye Y, Kozikowski AP. Synthesis and pharmacological evaluation of (Z)-9-(heteroarylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes: thiophene analogues as potent norepinephrine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 3565-9. PMID 14505672 DOI: 10.1016/S0960-894X(03)00786-8  0.427
2003 Quinlivan M, Mattner F, Papazian V, Zhou J, Katsifis A, Emond P, Chalon S, Kozikowski A, Guilloteau D, Kassiou M. Synthesis and evaluation of iodine-123 labelled tricyclic tropanes as radioligands for the serotonin transporter. Nuclear Medicine and Biology. 30: 741-6. PMID 14499332 DOI: 10.1016/S0969-8051(03)00076-3  0.383
2003 Zhou J, Zhang A, Kläss T, Johnson KM, Wang CZ, Ye YP, Kozikowski AP. Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites. Journal of Medicinal Chemistry. 46: 1997-2007. PMID 12723962 DOI: 10.1021/Jm020596W  0.432
1999 Kozikowski AP, Simoni D, Roberti M, Rondanin R, Wang S, Du P, Johnson KM. Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity. Bioorganic & Medicinal Chemistry Letters. 9: 1831-6. PMID 10406650 DOI: 10.1016/S0960-894X(99)00273-5  0.468
1999 Simoni D, Roberti M, Rondanin R, Kozikowski AP. Enantioselective deprotonation of the 8-oxabicyclo[3.2.1]octan-3-one: Synthesis of 8-oxa-norcocaines and 8-oxa-pseudonorcocaines Tetrahedron Letters. 40: 4425-4428. DOI: 10.1016/S0040-4039(99)00763-7  0.47
1996 Kozikowski AP, Simoni D, Manfredini S, Roberti M, Stoelwinder J. Synthesis of the 6- and 7-hydroxylated cocaines and pseudococaines Tetrahedron Letters. 37: 5333-5336. DOI: 10.1016/0040-4039(96)01123-9  0.449
1993 Malaska MJ, Fauq AH, Kozikowski AP, Aagaard PJ, McKinney M. Simplified analogs of himbacine displaying potent binding affinity for muscarinic receptors Bioorganic & Medicinal Chemistry Letters. 3: 1247-1252. DOI: 10.1016/S0960-894X(00)80325-X  0.584
1992 Kozikowski AP, Roberti M, Xiang L, Bergmann JS, Callahan PM, Cunningham KA, Johnson KM. Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue. Journal of Medicinal Chemistry. 35: 4764-6. PMID 1469704 DOI: 10.1021/Jm00103A015  0.452
1985 Kozikowski AP, Ghosh AK. Methods for Pyranoannulation: An Approach to a New Class of Polyethers. The Journal of Organic Chemistry. 50: 3017-3019. PMID 31285634 DOI: 10.1002/Chin.198552215  0.477
1984 Kozikowski AP, Ghosh AK. Diastereofacial Selection in Nitrile Oxide Cycloaddition Reactions. The Anti-Directing Effect of an Allylic Oxygen and Some New Results on the Ring Metalation of Isoxazolines. A Synthesis of (±)-Blastmycinone. The Journal of Organic Chemistry. 49: 2762-2772. PMID 31527928 DOI: 10.1002/Chin.198451113  0.484
1983 Kozikowski AP, Ghosh AK. The Isoxazoline Route to α-Methylene Lactones. Tetrahedron Letters. 24: 2623-2626. PMID 31595093 DOI: 10.1016/S0040-4039(00)87961-7  0.472
1982 Kozikowski AP, Ghosh AK. Diastereoselection in Intermolecular Nitrile Oxide Cycloaddition (NOC) Reactions: Confirmation of the "Anti-Periplanar Effect" through a Simple Synthesis of 2-Deoxy-d-ribose. Journal of the American Chemical Society. 104: 5788-5789. PMID 31156251 DOI: 10.1002/Chin.198304355  0.474
1978 Corey E, Bock MG, Kozikowski A, Rao A, Floyd D, Lipshutz B. A key intermediate for the synthesis of maytansine and related antitumor agents Tetrahedron Letters. 19: 1051-1054. DOI: 10.1016/S0040-4039(01)85449-6  0.439
1977 Corey E, Wetter HF, Kozikowski A, Rama Rao A. Preparation of a benzenoid intermediate For use in the synthesis of Maytansine Tetrahedron Letters. 18: 777-778. DOI: 10.1016/S0040-4039(01)92752-2  0.437
1975 Corey EJ, Kozikowski AP. Bis(dimethylaluminum) 1,3-propanedithiolate-a useful reagent in the conversion of esters to unsaturated aldehydes and ketones Tetrahedron Letters. 16: 925-928. DOI: 10.1016/S0040-4039(00)72021-1  0.435
1975 Corey EJ, Kozikowski AP. 3-hydroxy-2-pyrone as a vinylketene equivalent for the synthesis of dihydrophenols and cyclohexenones Tetrahedron Letters. 16: 2389-2392. DOI: 10.1016/0040-4039(75)80019-0  0.444
1973 Dauben WG, Hart DJ, Ipaktschi J, Kozikowski AP. A facile synthesis of substituted conjugated cyclohexadienes Tetrahedron Letters. 14: 4425-4428. DOI: 10.1016/S0040-4039(01)87239-7  0.557
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