| Year |
Citation |
Score |
| 2017 |
Huang J, Wang L, Dahiya S, Beier UH, Han R, Samanta A, Bergman J, Sotomayor EM, Seto E, Kozikowski AP, Hancock WW. Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Scientific Reports. 7: 8626. PMID 28819166 DOI: 10.1038/S41598-017-09211-3 |
0.309 |
|
| 2017 |
Ugolkov A, Qiang W, Bondarenko G, Procissi D, Gaisina I, James CD, Chandler J, Kozikowski A, Gunosewoyo H, O'Halloran T, Raizer J, Mazar AP. Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models. Translational Oncology. 10: 669-678. PMID 28672195 DOI: 10.1016/J.Tranon.2017.06.003 |
0.315 |
|
| 2017 |
Zhang G, Cheng J, McCorvy JD, Lorello PJ, Caldarone BJ, Roth BL, Kozikowski AP. Discovery of N-Substituted 2-Phenylcyclopropylmethylamines as Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists for Potential Use as Antipsychotic Medications. Journal of Medicinal Chemistry. PMID 28657744 DOI: 10.1021/Acs.Jmedchem.7B00584 |
0.354 |
|
| 2017 |
Lv W, Zhang G, Barinka C, Eubanks JH, Kozikowski AP. Design and Synthesis of Mercaptoacetamides as Potent, Selective, and Brain Permeable Histone Deacetylase 6 Inhibitors. Acs Medicinal Chemistry Letters. 8: 510-515. PMID 28523102 DOI: 10.1021/Acsmedchemlett.7B00012 |
0.375 |
|
| 2017 |
Pogorelov VM, Rodriguiz RM, Cheng J, Huang M, Schmerberg CM, Meltzer HY, Roth BL, Kozikowski AP, Wetsel WC. 5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28294132 DOI: 10.1038/Npp.2017.52 |
0.303 |
|
| 2017 |
Budke B, Lv W, Tueckmantel W, Kozikowski A, Connell P. Abstract PR02: Small molecules that specifically inhibit the D-loop activity of RAD51 Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-Pr02 |
0.367 |
|
| 2017 |
Kim J, Nair JR, Hadley MM, Kozikowski A, Miller R, Villagra A. Abstract LB-295: A novel regulatory role of HDAC6 in the functional inflammatory phenotype of glia cells Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-295 |
0.301 |
|
| 2017 |
Hadley M, Shen S, Banik D, Kim J, Nair J, Knox T, Gallub V, Kirkland S, Chiappinelli KB, Sotomayor E, Kozikowski A, Villagra A. Abstract LB-294:In vivoevaluation of Ames negative HDAC6 inhibitor in melanoma model Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-294 |
0.367 |
|
| 2017 |
Banik D, Hadley M, Kim J, Knox T, Nair J, Kozikowski A, Shen S, Vyas C, Donohue A, Sotomayor E, Villagra A. Abstract 4854: Evaluating HDAC6 as a causal factor in metastatic breast cancer to develop immunotherapy Cancer Research. 77: 4854-4854. DOI: 10.1158/1538-7445.Am2017-4854 |
0.318 |
|
| 2017 |
Damião MCFCB, Galaverna R, Kozikowski AP, Eubanks J, Pastre JC. Telescoped continuous flow generation of a library of highly substituted 3-thio-1,2,4-triazoles Reaction Chemistry and Engineering. 2: 896-907. DOI: 10.1039/C7Re00125H |
0.304 |
|
| 2016 |
Cheng J, McCorvy JD, Giguère PM, Zhu H, Kenakin T, Roth BL, Kozikowski AP. Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists. Journal of Medicinal Chemistry. PMID 27726356 DOI: 10.1021/Acs.Jmedchem.6B01194 |
0.325 |
|
| 2016 |
Zhang HK, Eaton JB, Fedolak A, Gunosewoyo H, Onajole OK, Brunner D, Lukas RJ, Yu LF, Kozikowski AP. Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists. European Journal of Medicinal Chemistry. 124: 689-697. PMID 27639361 DOI: 10.1016/J.Ejmech.2016.09.016 |
0.351 |
|
| 2016 |
Stec J, Onajole OK, Lun S, Guo H, Merenbloom B, Vistoli G, Bishai WR, Kozikowski AP. Indole-2-carboxamide-Based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection. Journal of Medicinal Chemistry. PMID 27275668 DOI: 10.1021/Acs.Jmedchem.6B00415 |
0.319 |
|
| 2016 |
Lv W, Budke B, Pawlowski M, Connell PP, Kozikowski AP. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. Journal of Medicinal Chemistry. PMID 27049177 DOI: 10.1016/J.Ijrobp.2016.06.053 |
0.324 |
|
| 2016 |
Onajole OK, Vallerini GP, Eaton JB, Lukas RJ, Brunner D, Caldarone BJ, Kozikowski AP. Synthesis and Behavioral Studies of Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile. Part III. Acs Chemical Neuroscience. PMID 27035276 DOI: 10.1021/Acschemneuro.6B00050 |
0.366 |
|
| 2016 |
Wang Z, Leng Y, Wang J, Liao HM, Bergman J, Leeds P, Kozikowski A, Chuang DM. Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation. Scientific Reports. 6: 19626. PMID 26790818 DOI: 10.1038/Srep19626 |
0.303 |
|
| 2016 |
Lienlaf M, Perez-Villarroel P, Knox T, Pabon M, Sahakian E, Powers J, Woan KV, Lee C, Cheng F, Deng S, Smalley KS, Montecino M, Kozikowski A, Pinilla-Ibarz J, Sarnaik A, et al. Essential role of HDAC6 in the regulation of PD-L1 in melanoma. Molecular Oncology. PMID 26775640 DOI: 10.1016/J.Molonc.2015.12.012 |
0.323 |
|
| 2015 |
Cheng J, Giguère PM, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Huang XP, Zhu H, McCorvy JD, Wetsel WC, Roth BL, Kozikowski AP. Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models. Journal of Medicinal Chemistry. PMID 26704965 DOI: 10.1021/Acs.Jmedchem.5B01153 |
0.334 |
|
| 2015 |
Lu S, Zhang Y, Kalin JH, Cai L, Kozikowski AP, Pike VW. Exploration of the labeling of [(11) C]tubastatin A at the hydroxamic acid site with [(11) C]carbon monoxide. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 26647018 DOI: 10.1002/Jlcr.3360 |
0.596 |
|
| 2015 |
Segretti MC, Vallerini GP, Brochier C, Langley B, Wang L, Hancock WW, Kozikowski AP. Thiol-Based Potent and Selective HDAC6 Inhibitors Promote Tubulin Acetylation and T-Regulatory Cell Suppressive Function. Acs Medicinal Chemistry Letters. 6: 1156-1161. PMID 26617971 DOI: 10.1021/Acsmedchemlett.5B00303 |
0.38 |
|
| 2015 |
Shen S, Kozikowski AP. Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors-What Some May Have Forgotten or Would Rather Forget? Chemmedchem. PMID 26603496 DOI: 10.1002/Cmdc.201500486 |
0.358 |
|
| 2015 |
Shen S, Benoy V, Bergman JA, Kalin JH, Frojuello M, Vistoli G, Haeck W, Van Den Bosch L, Kozikowski AP. Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease. Acs Chemical Neuroscience. PMID 26599234 DOI: 10.1021/Acschemneuro.5B00286 |
0.655 |
|
| 2015 |
Gaisina IN, Tueckmantel W, Ugolkov A, Shen S, Hoffen J, Dubrovskyi O, Mazar A, Schoon RA, Billadeau D, Kozikowski AP. Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity. Chemmedchem. PMID 26592932 DOI: 10.1002/Cmdc.201500456 |
0.379 |
|
| 2015 |
Cheng J, Kozikowski AP. We Need 2C but Not 2B: Developing Serotonin 2C (5-HT2C ) Receptor Agonists for the Treatment of CNS Disorders. Chemmedchem. PMID 26507582 DOI: 10.1002/Cmdc.201500437 |
0.3 |
|
| 2015 |
Cheng J, Giguere PM, Lv W, Roth BL, Kozikowski AP. Design and Synthesis of (2-(5-Chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a Selective Serotonin 2C Agonist. Tetrahedron Letters. 56: 3420-3422. PMID 26120215 DOI: 10.1016/J.Tetlet.2015.01.060 |
0.348 |
|
| 2015 |
Woan KV, Lienlaf M, Perez-Villaroel P, Lee C, Cheng F, Knox T, Woods DM, Barrios K, Powers J, Sahakian E, Wang HW, Canales J, Marante D, Smalley KS, Bergman J, ... ... Kozikowski A, et al. Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation. Molecular Oncology. PMID 25957812 DOI: 10.1016/J.Molonc.2015.04.002 |
0.333 |
|
| 2015 |
Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP. Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents. Journal of Medicinal Chemistry. 58: 1992-2002. PMID 25633969 DOI: 10.1021/Jm5019274 |
0.349 |
|
| 2015 |
Dubrovskyi O, Ugolkov A, Gaisina I, Bondarenko G, Strizzi L, Margaryan N, O'Halloran T, Kozikowski A, Hendrix M, Mazar A. Abstract 3287: Targeting GSK-3: a new approach for the treatment of neuroblastoma Cancer Research. 75: 3287-3287. DOI: 10.1158/1538-7445.Am2015-3287 |
0.35 |
|
| 2015 |
Ugolkov A, Dubrovskyi O, Gaisina I, Yemelyanov A, Bondarenko G, James C, Chandler J, O'Halloran T, Kozikowski A, Raizer J, Mazar A. Abstract 2699: Targeting GSK-3: a novel approach to enhance glioblastoma chemosensitivity Cancer Research. 75: 2699-2699. DOI: 10.1158/1538-7445.Am2015-2699 |
0.316 |
|
| 2015 |
Ugolkov A, Bondarenko G, Gaisina I, Dubrovskyi O, Yemelyanov A, James C, Chandler J, O'Halloran T, Kozikowski A, Raizer J, Mazar A. ATPS-91GSK-3 INHIBITOR 9-ING-41 ENHANCES GENOTOXIC THERAPY OF GBM LEADING TO CURE FROM INTRACRANIAL BRAIN TUMOR Neuro-Oncology. 17: v38.3-v38. DOI: 10.1093/Neuonc/Nov204.91 |
0.301 |
|
| 2014 |
Yu LF, Brek Eaton J, Zhang HK, Sabath E, Hanania T, Li GN, van Breemen RB, Whiteaker P, Liu Q, Wu J, Chang YC, Lukas RJ, Brunner D, Kozikowski AP. The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile. Pharmacology Research & Perspectives. 2: e00026. PMID 25505580 DOI: 10.1002/Prp2.26 |
0.301 |
|
| 2014 |
Onajole OK, Eaton JB, Lukas RJ, Brunner D, Thiede L, Caldarone BJ, Kozikowski AP. Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4β2-nAChR Ligands. Acs Medicinal Chemistry Letters. 5: 1196-201. PMID 25408831 DOI: 10.1021/Ml500129K |
0.319 |
|
| 2014 |
Stec J, Vilchèze C, Lun S, Perryman AL, Wang X, Freundlich JS, Bishai W, Jacobs WR, Kozikowski AP. Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis. Chemmedchem. 9: 2528-37. PMID 25165007 DOI: 10.1002/Cmdc.201402255 |
0.355 |
|
| 2014 |
Cheng F, Lienlaf M, Wang HW, Perez-Villarroel P, Lee C, Woan K, Rock-Klotz J, Sahakian E, Woods D, Pinilla-Ibarz J, Kalin J, Tao J, Hancock W, Kozikowski A, Seto E, et al. A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs. Journal of Immunology (Baltimore, Md. : 1950). 193: 2850-62. PMID 25108026 DOI: 10.4049/Jimmunol.1302778 |
0.619 |
|
| 2014 |
Mason JM, Logan HL, Budke B, Wu M, Pawlowski M, Weichselbaum RR, Kozikowski AP, Bishop DK, Connell PP. The rad51-stimulatory compound rs-1 can exploit the rad51 overexpression that exists in cancer cells and tumors Cancer Research. 74: 3546-3555. PMID 24753542 DOI: 10.1158/0008-5472.Can-13-3220 |
0.309 |
|
| 2014 |
Xu X, Kozikowski AP, Pozzo-Miller L. A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome. Frontiers in Cellular Neuroscience. 8: 68. PMID 24639629 DOI: 10.3389/Fncel.2014.00068 |
0.303 |
|
| 2014 |
Selenica ML, Benner L, Housley SB, Manchec B, Lee DC, Nash KR, Kalin J, Bergman JA, Kozikowski A, Gordon MN, Morgan D. Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition. Alzheimer's Research & Therapy. 6: 12. PMID 24576665 DOI: 10.1186/Alzrt241 |
0.624 |
|
| 2014 |
Pal K, Cao Y, Gaisina IN, Bhattacharya S, Dutta SK, Wang E, Gunosewoyo H, Kozikowski AP, Billadeau DD, Mukhopadhyay D. Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer. Molecular Cancer Therapeutics. 13: 285-96. PMID 24327518 DOI: 10.1158/1535-7163.Mct-13-0681 |
0.31 |
|
| 2014 |
Alvarez A, Ugolkov A, Gaisina I, Kozikowski AP, Joshi K, Kim S, Nakano I, Raizer JJ, Mazar AP, Hu B, Cheng S. Abstract 1941: GSK3 signaling is critical to glioma stem cell growth and survival Cancer Research. 74: 1941-1941. DOI: 10.1158/1538-7445.Am2014-1941 |
0.304 |
|
| 2013 |
Lun S, Guo H, Onajole OK, Pieroni M, Gunosewoyo H, Chen G, Tipparaju SK, Ammerman NC, Kozikowski AP, Bishai WR. Indoleamides are active against drug-resistant mycobacterium tuberculosis Nature Communications. 4. PMID 24352433 DOI: 10.1038/Ncomms3907 |
0.339 |
|
| 2013 |
Stec J, Fomovska A, Afanador GA, Muench SP, Zhou Y, Lai BS, El Bissati K, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Sommervile C, Woods S, Roberts CW, Rice D, ... ... Kozikowski AP, et al. Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii. Chemmedchem. 8: 1138-60. PMID 23776166 DOI: 10.1002/Cmdc.201300050 |
0.365 |
|
| 2013 |
Gunosewoyo H, Midzak A, Gaisina IN, Sabath EV, Fedolak A, Hanania T, Brunner D, Papadopoulos V, Kozikowski AP. Characterization of maleimide-based glycogen synthase kinase-3 (GSK-3) inhibitors as stimulators of steroidogenesis. Journal of Medicinal Chemistry. 56: 5115-29. PMID 23725591 DOI: 10.1021/Jm400511S |
0.341 |
|
| 2013 |
Gunosewoyo H, Tipparaju SK, Pieroni M, Wang Y, Doctor BP, Nambiar MP, Kozikowski AP. Structural analogs of huperzine A improve survival in guinea pigs exposed to soman. Bioorganic & Medicinal Chemistry Letters. 23: 1544-7. PMID 23395652 DOI: 10.1016/J.Bmcl.2012.11.083 |
0.307 |
|
| 2013 |
Budke B, Kalin JH, Pawlowski M, Zelivianskaia AS, Wu M, Kozikowski AP, Connell PP. An optimized RAD51 inhibitor that disrupts homologous recombination without requiring michael acceptor reactivity Journal of Medicinal Chemistry. 56: 254-263. PMID 23231413 DOI: 10.1021/Jm301565B |
0.619 |
|
| 2012 |
Gills JJ, Zhang C, Abu-Asab MS, Castillo SS, Marceau C, LoPiccolo J, Kozikowski AP, Tsokos M, Goldkorn T, Dennis PA. Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine Cell Death and Disease. 3. PMID 22764099 DOI: 10.1038/Cddis.2012.72 |
0.327 |
|
| 2012 |
Budke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL, Stark JM, Kozikowski AP, Bishop DK, Connell PP. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Research. 40: 7347-57. PMID 22573178 DOI: 10.1093/Nar/Gks353 |
0.611 |
|
| 2012 |
Fomovska A, Huang Q, El Bissati K, Mui EJ, Witola WH, Cheng G, Zhou Y, Sommerville C, Roberts CW, Bettis S, Prigge ST, Afanador GA, Hickman MR, Lee PJ, Leed SE, ... ... Kozikowski AP, et al. Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway. Antimicrobial Agents and Chemotherapy. 56: 2666-82. PMID 22354304 DOI: 10.1128/Aac.06450-11 |
0.331 |
|
| 2012 |
Stec J, Huang Q, Pieroni M, Kaiser M, Fomovska A, Mui E, Witola WH, Bettis S, McLeod R, Brun R, Kozikowski AP. Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania. Journal of Medicinal Chemistry. 55: 3088-100. PMID 22352841 DOI: 10.1021/Jm2015183 |
0.329 |
|
| 2012 |
Kalin JH, Zhang H, Gaudrel-Grosay S, Vistoli G, Kozikowski AP. Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress Chemmedchem. 7: 425-439. PMID 22234885 DOI: 10.1002/Cmdc.201100522 |
0.665 |
|
| 2012 |
Kalin JH, Butler KV, Akimova T, Hancock WW, Kozikowski AP. Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells Journal of Medicinal Chemistry. 55: 639-651. PMID 22165909 DOI: 10.1021/jm200773h |
0.633 |
|
| 2012 |
Cheng F, Wang Z, Wang H, Lienlaf M, Woan KV, Perez-Villarroel P, Rock-Klotz J, Sahakian E, Knox T, Woods DM, Powers J, Han R, Merino O, Deng S, Marante D, ... ... Kozikowski A, et al. Physical Interaction of Histone Deacetylase 6 (HDAC6) with STAT3 Regulates IL-10 Gene Expression and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs) Blood. 120: 829-829. DOI: 10.1182/Blood.V120.21.829.829 |
0.317 |
|
| 2012 |
Wang H, Cheng F, Wang Z, Lienlaf M, Perez-Villarroel P, Knox T, Sahakian E, Pinilla-Ibarz J, Horna P, Chen-Kiang S, Martin P, Bergman J, Kozikowski A, Villagra A, Tao J, et al. Inhibition of Histone Deacetylase 6 (HDAC6) Disrupts the Tolerogenic STAT3 Signaling Pathway and Augments Antitumor Immune Responses in Mantle Cell Lymphoma (MCL) Blood. 120: 3724-3724. DOI: 10.1182/Blood.V120.21.3724.3724 |
0.323 |
|
| 2012 |
Woan KV, Vazquez L, Rock-Klotz J, Wang Z, Cheng F, Wang H, Woods D, Sahakian E, Perez P, Lienlaf M, Achille A, Bergman J, Kalin J, Gill A, Powers J, ... ... Kozikowski AP, et al. Abstract 3555: Histone deacetylase 6 as a novel regulator of the immunogenicity and aggressiveness of melanoma Cancer Research. 72: 3555-3555. DOI: 10.1158/1538-7445.Am2012-3555 |
0.642 |
|
| 2011 |
Chen G, Cho SJ, Huang XP, Jensen NH, Svennebring A, Sassano MF, Roth BL, Kozikowski AP. Rational Drug Design Leading to the Identification of a Potent 5-HT(2C) Agonist Lacking 5-HT(2B) Activity. Acs Medicinal Chemistry Letters. 2: 929-932. PMID 22778800 DOI: 10.1021/Ml200206Z |
0.347 |
|
| 2011 |
Chen W, Gaisina IN, Gunosewoyo H, Malekiani SA, Hanania T, Kozikowski AP. Structure-guided design of a highly selective glycogen synthase kinase-3β inhibitor: a superior neuroprotective pyrazolone showing antimania effects. Chemmedchem. 6: 1587-92. PMID 21751402 DOI: 10.1002/Cmdc.201100231 |
0.319 |
|
| 2011 |
Kozikowski AP, Gunosewoyo H, Guo S, Gaisina IN, Walter RL, Ketcherside A, McClung CA, Mesecar AD, Caldarone B. Identification of a glycogen synthase kinase-3β inhibitor that attenuates hyperactivity in CLOCK mutant mice. Chemmedchem. 6: 1593-602. PMID 21732538 DOI: 10.1002/Cmdc.201100188 |
0.361 |
|
| 2011 |
de Zoeten EF, Wang L, Butler K, Beier UH, Akimova T, Sai H, Bradner JE, Mazitschek R, Kozikowski AP, Matthias P, Hancock WW. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3+ T-regulatory cells Molecular and Cellular Biology. 31: 2066-2078. PMID 21444725 DOI: 10.1128/Mcb.05155-11 |
0.324 |
|
| 2011 |
Wang H, Wang Z, Cheng F, Woan KV, Rock-Klotz J, Sahakian E, Powers J, Javier P, Bergman J, Villagra A, Kozikowski A, Sotomayor EM. Tubastatin A, a Selective HDAC6 Inhibitor, Enhances Antigen-Presenting Cell (APC) Function and Restores the Responsiveness of Anergic CD4+ T Cells Blood. 118: 520-520. DOI: 10.1182/Blood.V118.21.520.520 |
0.319 |
|
| 2011 |
Gills JJ, Zhang C, Abu-Asab MS, Castillo SS, Marceau C, Kozikowski A, Tsokos M, Goldkorn T, Dennis PA. Abstract 960: Ceramide-dependent release of nanovesicles is a class effect oflipid-based Akt inhibitors Cancer Research. 71: 960-960. DOI: 10.1158/1538-7445.Am2011-960 |
0.339 |
|
| 2010 |
Caldarone BJ, Paterson NE, Zhou J, Brunner D, Kozikowski AP, Westphal KG, Korte-Bouws GA, Prins J, Korte SM, Olivier B, Ghavami A. The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. The Journal of Pharmacology and Experimental Therapeutics. 335: 762-70. PMID 20864506 DOI: 10.1124/Jpet.110.174011 |
0.465 |
|
| 2010 |
Tipparaju SK, Muench SP, Mui EJ, Ruzheinikov SN, Lu JZ, Hutson SL, Kirisits MJ, Prigge ST, Roberts CW, Henriquez FL, Kozikowski AP, Rice DW, McLeod RL. Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase. Journal of Medicinal Chemistry. 53: 6287-300. PMID 20698542 DOI: 10.1021/Jm9017724 |
0.353 |
|
| 2010 |
Butler KV, Kalin J, Brochier C, Vistoli G, Langley B, Kozikowski AP. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A Journal of the American Chemical Society. 132: 10842-10846. PMID 20614936 DOI: 10.1021/Ja102758V |
0.655 |
|
| 2010 |
Smirnova NA, Rakhman I, Moroz N, Basso M, Payappilly J, Kazakov S, Hernandez-Guzman F, Gaisina IN, Kozikowski AP, Ratan RR, Gazaryan IG. Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. Chemistry & Biology. 17: 380-91. PMID 20416509 DOI: 10.1016/J.Chembiol.2010.03.008 |
0.302 |
|
| 2010 |
He R, Chen Y, Ougolkov AV, Zhang JS, Savoy DN, Billadeau DD, Kozikowski AP. Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents Journal of Medicinal Chemistry. 53: 1347-1356. PMID 20055418 DOI: 10.1021/Jm901667K |
0.346 |
|
| 2010 |
Lilienkampf A, Pieroni M, Wan B, Wang Y, Franzblau SG, Kozikowski AP. Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. A potent and selective series for further drug development Journal of Medicinal Chemistry. 53: 678-688. PMID 20000577 DOI: 10.1021/Jm901273N |
0.339 |
|
| 2009 |
Rivieccio MA, Brochier C, Willis DE, Walker BA, D'Annibale MA, McLaughlin K, Siddiq A, Kozikowski AP, Jaffrey SR, Twiss JL, Ratan RR, Langley B. HDAC6 is a target for protection and regeneration following injury in the nervous system. Proceedings of the National Academy of Sciences of the United States of America. 106: 19599-604. PMID 19884510 DOI: 10.1073/Pnas.0907935106 |
0.318 |
|
| 2009 |
Guo S, Tipparaju SK, Pegan SD, Wan B, Mo S, Orjala J, Mesecar AD, Franzblau SG, Kozikowski AP. Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents. Bioorganic & Medicinal Chemistry. 17: 7126-30. PMID 19783449 DOI: 10.1016/J.Bmc.2009.08.061 |
0.359 |
|
| 2009 |
Butler KV, He R, McLaughlin K, Vistoli G, Langley B, Kozikowski AP. Stereoselective HDAC inhibition from cysteine-derived zinc-binding groups. Chemmedchem. 4: 1292-301. PMID 19551801 DOI: 10.1002/Cmdc.200900088 |
0.404 |
|
| 2009 |
Kalin JH, Butler KV, Kozikowski AP. Creating zinc monkey wrenches in the treatment of epigenetic disorders Current Opinion in Chemical Biology. 13: 263-271. PMID 19541531 DOI: 10.1016/J.Cbpa.2009.05.007 |
0.629 |
|
| 2009 |
Tapadar S, He R, Luchini DN, Billadeau DD, Kozikowski AP. Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity Bioorganic and Medicinal Chemistry Letters. 19: 3023-3026. PMID 19419863 DOI: 10.1016/J.Bmcl.2009.04.058 |
0.38 |
|
| 2009 |
Kozikowski AP, Chen Y, Subhasish T, Lewin NE, Blumberg PM, Zhong Z, D'Annibale MA, Wang WL, Shen Y, Langley B. Searching for disease modifiers - PKC activation and HDAC inhibition - A dual drug approach to Alzheimer's disease that decreases Aβ production while blocking oxidative stress Chemmedchem. 4: 1095-1105. PMID 19396896 DOI: 10.1002/Cmdc.200900045 |
0.36 |
|
| 2009 |
Sleiman SF, Basso M, Mahishi L, Kozikowski AP, Donohoe ME, Langley B, Ratan RR. Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions. Expert Opinion On Investigational Drugs. 18: 573-84. PMID 19388875 DOI: 10.1517/13543780902810345 |
0.34 |
|
| 2009 |
Chen Y, He R, D'Annibale MA, Langley B, Kozikowski AP. Studies of benzamide- and thiol-based histone deacetylase inhibitors in models of oxidative-stress-induced neuronal death: Identification of some HDAC3-selective inhibitors Chemmedchem. 4: 842-852. PMID 19350613 DOI: 10.1002/Cmdc.200800461 |
0.348 |
|
| 2009 |
Gaisina IN, Gallier F, Ougolkov AV, Kim KH, Kurome T, Guo S, Holzle D, Luchini DN, Blond SY, Billadeau DD, Kozikowski AP. From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3βinhibitors that suppress proliferation and survival of pancreatic cancer cells Journal of Medicinal Chemistry. 52: 1853-1863. PMID 19338355 DOI: 10.1021/Jm801317H |
0.327 |
|
| 2009 |
Chirapu SR, Pachaiyappan B, Nural HF, Cheng X, Yuan H, Lankin DC, Abdul-Hay SO, Thatcher GR, Shen Y, Kozikowski AP, Petukhov PA. Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 264-74. PMID 19013792 DOI: 10.1016/J.Bmcl.2008.10.096 |
0.357 |
|
| 2009 |
Cheng F, Wang H, Luetteke N, Pinilla J, Kozikowski A, Seto E, Villagra Av, Sotomayor E. A Novel Role for Histone Deacetylase 6 (HDAC6) in the Regulation of IL-10 and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs). Blood. 114: 1360-1360. DOI: 10.1182/Blood.V114.22.1360.1360 |
0.324 |
|
| 2008 |
Mao J, Eoh H, He R, Wang Y, Wan B, Franzblau SG, Crick DC, Kozikowski AP. Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorganic & Medicinal Chemistry Letters. 18: 5320-3. PMID 18783951 DOI: 10.1016/J.Bmcl.2008.08.034 |
0.335 |
|
| 2008 |
Yamamoto T, Kozikowski A, Zhou J, Neale JH. Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain. Molecular Pain. 4: 31. PMID 18673570 DOI: 10.1186/1744-8069-4-31 |
0.418 |
|
| 2008 |
Tipparaju SK, Mulhearn DC, Klein GM, Chen Y, Tapadar S, Bishop MH, Yang S, Chen J, Ghassemi M, Santarsiero BD, Cook JL, Johlfs M, Mesecar AD, Johnson ME, Kozikowski AP. Design and synthesis of aryl ether inhibitors of the Bacillus anthracis enoyl-ACP reductase. Chemmedchem. 3: 1250-68. PMID 18663709 DOI: 10.1002/Cmdc.200800047 |
0.334 |
|
| 2008 |
Dow GS, Chen Y, Andrews KT, Caridha D, Gerena L, Gettayacamin M, Johnson J, Li Q, Melendez V, Obaldia N, Tran TN, Kozikowski AP. Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors Antimicrobial Agents and Chemotherapy. 52: 3467-3477. PMID 18644969 DOI: 10.1128/Aac.00439-08 |
0.326 |
|
| 2008 |
Kozikowski AP, Tapadar S, Luchini DN, Ki HK, Billadeau DD. Use of the Nitrile Oxide Cycloaddition (NOC) reaction for molecular probe generation: A new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6 Journal of Medicinal Chemistry. 51: 4370-4373. PMID 18642892 DOI: 10.1021/Jm8002894 |
0.392 |
|
| 2008 |
Banerjee SR, Foss CA, Castanares M, Mease RC, Byun Y, Fox JJ, Hilton J, Lupold SE, Kozikowski AP, Pomper MG. Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA) Journal of Medicinal Chemistry. 51: 4504-4517. PMID 18637669 DOI: 10.1021/Jm800111U |
0.302 |
|
| 2008 |
Zhang B, West EJ, Van KC, Gurkoff GG, Zhou J, Zhang XM, Kozikowski AP, Lyeth BG. HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats. Brain Research. 1226: 181-91. PMID 18582446 DOI: 10.1016/J.Brainres.2008.05.085 |
0.425 |
|
| 2008 |
Tipparaju SK, Joyasawal S, Forrester S, Mulhearn DC, Pegan S, Johnson ME, Mesecar AD, Kozikowski AP. Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase. Bioorganic & Medicinal Chemistry Letters. 18: 3565-9. PMID 18499454 DOI: 10.1016/J.Bmcl.2008.05.004 |
0.348 |
|
| 2008 |
Chen Y, Lopez-Sanchez M, Savoy DN, Billadeau DD, Dow GS, Kozikowski AP. A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum Journal of Medicinal Chemistry. 51: 3437-3448. PMID 18494463 DOI: 10.1021/Jm701606B |
0.405 |
|
| 2008 |
Kozikowski AP, Chen Y, Gaysin AM, Savoy DN, Billadeau DD, Kim KH. Chemistry, biology, and QSAR studies of substituted biaryl hydroxamates and mercaptoacetamides as HDAC inhibitors - Nanomolar-potency inhibitors of pancreatic cancer cell growth Chemmedchem. 3: 487-501. PMID 18181121 DOI: 10.1002/Cmdc.200700314 |
0.388 |
|
| 2008 |
Olszewski RT, Wegorzewska MM, Monteiro AC, Krolikowski KA, Zhou J, Kozikowski AP, Long K, Mastropaolo J, Deutsch SI, Neale JH. Phencyclidine and Dizocilpine Induced Behaviors Reduced by N-acetylaspartylglutamate Peptidase Inhibition via Metabotropic Glutamate Receptors Biological Psychiatry. 63: 86-91. PMID 17597589 DOI: 10.1016/J.Biopsych.2007.04.016 |
0.435 |
|
| 2007 |
Kozikowski AP, Gaisina IN, Yuan H, Petukhov PA, Blond SY, Fedolak A, Caldarone B, McGonigle P. Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders. Journal of the American Chemical Society. 129: 8328-32. PMID 17552518 DOI: 10.1021/Ja068969W |
0.318 |
|
| 2007 |
Kozikowski AP, Chen Y, Gaysin A, Chen B, D'Annibale MA, Suto CM, Langley BC. Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies. Journal of Medicinal Chemistry. 50: 3054-61. PMID 17539623 DOI: 10.1021/Jm070178X |
0.345 |
|
| 2007 |
Yamamoto T, Saito O, Aoe T, Bartolozzi A, Sarva J, Zhou J, Kozikowski A, Wroblewska B, Bzdega T, Neale JH. Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. The European Journal of Neuroscience. 25: 147-58. PMID 17241276 DOI: 10.1111/J.1460-9568.2006.05272.X |
0.351 |
|
| 2006 |
Kozikowski AP, Gaisina IN, Petukhov PA, Sridhar J, King LT, Blond SY, Duka T, Rusnak M, Sidhu A. Highly potent and specific GSK-3β inhibitors that block tau phosphorylation and decrease α-synuclein protein expression in a cellular model of Parkinson's disease Chemmedchem. 1: 256-266. PMID 16892358 DOI: 10.1002/Cmdc.200500039 |
0.327 |
|
| 2006 |
Musachio JL, Hong J, Ichise M, Seneca N, Brown AK, Liow JS, Halldin C, Innis RB, Pike VW, He R, Zhou J, Kozikowski AP. Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 3101-4. PMID 16621532 DOI: 10.1016/J.Bmcl.2006.03.066 |
0.439 |
|
| 2006 |
Zhong C, Zhao X, Van KC, Bzdega T, Smyth A, Zhou J, Kozikowski AP, Jiang J, O'Connor WT, Berman RF, Neale JH, Lyeth BG. NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat. Journal of Neurochemistry. 97: 1015-25. PMID 16606367 DOI: 10.1111/J.1471-4159.2006.03786.X |
0.406 |
|
| 2006 |
Gills JJ, Holbeck S, Hollingshead M, Hewitt SM, Kozikowski AP, Dennis PA. Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt Molecular Cancer Therapeutics. 5: 713-722. PMID 16546986 DOI: 10.1158/1535-7163.Mct-05-0484 |
0.343 |
|
| 2006 |
Iso Y, Grajkowska E, Wroblewski JT, Davis J, Goeders NE, Johnson KM, Sanker S, Roth BL, Tueckmantel W, Kozikowski AP. Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications. Journal of Medicinal Chemistry. 49: 1080-100. PMID 16451073 DOI: 10.1021/Jm050570F |
0.35 |
|
| 2006 |
Wee S, Wang Z, He R, Zhou J, Kozikowski AP, Woolverton WL. Role of the increased noradrenergic neurotransmission in drug self-administration. Drug and Alcohol Dependence. 82: 151-7. PMID 16213110 DOI: 10.1016/J.Drugalcdep.2005.09.002 |
0.399 |
|
| 2005 |
Zhou J, Neale JH, Pomper MG, Kozikowski AP. NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nature Reviews. Drug Discovery. 4: 1015-26. PMID 16341066 DOI: 10.1038/Nrd1903 |
0.471 |
|
| 2005 |
He R, Kurome T, Giberson KM, Johnson KM, Kozikowski AP. Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors. Journal of Medicinal Chemistry. 48: 7970-9. PMID 16335921 DOI: 10.1021/Jm050694S |
0.331 |
|
| 2005 |
Guilarte TR, McGlothan JL, Foss CA, Zhou J, Heston WD, Kozikowski AP, Pomper MG. Glutamate carboxypeptidase II levels in rodent brain using [125I]DCIT quantitative autoradiography. Neuroscience Letters. 387: 141-4. PMID 16006038 DOI: 10.1016/J.Neulet.2005.06.015 |
0.418 |
|
| 2005 |
Zhou J, Kläss T, Johnson KM, Giberson KM, Kozikowski AP. Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants. Bioorganic & Medicinal Chemistry Letters. 15: 2461-5. PMID 15863297 DOI: 10.1016/J.Bmcl.2005.03.083 |
0.5 |
|
| 2005 |
Jung M, Velena A, Chen B, Petukhov PA, Kozikowski AP, Dritschilo A. Novel HDAC inhibitors with radiosensitizing properties Radiation Research. 163: 488-493. PMID 15850409 DOI: 10.1667/Rr3345 |
0.393 |
|
| 2005 |
Chen B, Petukhov PA, Jung M, Velena A, Eliseeva E, Dritschilo A, Kozikowski AP. Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors Bioorganic and Medicinal Chemistry Letters. 15: 1389-1392. PMID 15713393 DOI: 10.1016/J.Bmcl.2005.01.006 |
0.392 |
|
| 2004 |
Zhou J, He R, Johnson KM, Ye Y, Kozikowski AP. Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization. Journal of Medicinal Chemistry. 47: 5821-4. PMID 15537337 DOI: 10.1021/Jm040117O |
0.451 |
|
| 2004 |
Pearce LV, Petukhov PA, Szabo T, Kedei N, Bizik F, Kozikowski AP, Blumberg PM. Evodiamine functions as an agonist for the vanilloid receptor TRPV1 Organic and Biomolecular Chemistry. 2: 2281-2286. PMID 15305207 DOI: 10.1039/B404506H |
0.311 |
|
| 2004 |
Yamamoto T, Hirasawa S, Wroblewska B, Grajkowska E, Zhou J, Kozikowski A, Wroblewski J, Neale JH. Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model. The European Journal of Neuroscience. 20: 483-94. PMID 15233757 DOI: 10.1111/J.1460-9568.2004.03504.X |
0.422 |
|
| 2004 |
Petukhov PA, Zhang J, Wang CZ, Ye YP, Johnson KM, Kozikowski AP. Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring. Journal of Medicinal Chemistry. 47: 3009-18. PMID 15163183 DOI: 10.1021/Jm0303296 |
0.307 |
|
| 2004 |
Olszewski RT, Bukhari N, Zhou J, Kozikowski AP, Wroblewski JT, Shamimi-Noori S, Wroblewska B, Bzdega T, Vicini S, Barton FB, Neale JH. NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. Journal of Neurochemistry. 89: 876-85. PMID 15140187 DOI: 10.1111/J.1471-4159.2004.02358.X |
0.364 |
|
| 2004 |
Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH. Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. Journal of Medicinal Chemistry. 47: 1729-38. PMID 15027864 DOI: 10.1021/Jm0306226 |
0.369 |
|
| 2003 |
Zhou J, Kläss T, Zhang A, Johnson KM, Wang CZ, Ye Y, Kozikowski AP. Synthesis and pharmacological evaluation of (Z)-9-(heteroarylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes: thiophene analogues as potent norepinephrine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 3565-9. PMID 14505672 DOI: 10.1016/S0960-894X(03)00786-8 |
0.416 |
|
| 2003 |
Quinlivan M, Mattner F, Papazian V, Zhou J, Katsifis A, Emond P, Chalon S, Kozikowski A, Guilloteau D, Kassiou M. Synthesis and evaluation of iodine-123 labelled tricyclic tropanes as radioligands for the serotonin transporter. Nuclear Medicine and Biology. 30: 741-6. PMID 14499332 DOI: 10.1016/S0969-8051(03)00076-3 |
0.364 |
|
| 2003 |
Zhou J, Zhang A, Kläss T, Johnson KM, Wang CZ, Ye YP, Kozikowski AP. Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites. Journal of Medicinal Chemistry. 46: 1997-2007. PMID 12723962 DOI: 10.1021/Jm020596W |
0.422 |
|
| 2003 |
Kozikowski AP, Sun H, Brognard J, Dennis PA. Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt Journal of the American Chemical Society. 125: 1144-1145. PMID 12553797 DOI: 10.1021/Ja0285159 |
0.515 |
|
| 2002 |
Ma D, Tang G, Kozikowski AP. Synthesis of 7-substituted benzolactam-V8s and their selectivity for protein kinase C isozymes Organic Letters. 4: 2377-2380. PMID 12098251 DOI: 10.1021/Ol026125L |
0.438 |
|
| 2002 |
Rong SB, Enyedy IJ, Qiao L, Zhao L, Ma D, Pearce LL, Lorenzo PS, Stone JC, Blumberg PM, Wang S, Kozikowski AP. Structural basis of RasGRP binding to high-affinity PKC ligands. Journal of Medicinal Chemistry. 45: 853-60. PMID 11831896 DOI: 10.1021/Jm010422Z |
0.411 |
|
| 2002 |
Sun H, Bapu Reddy G, George C, Meuillet EJ, Berggren M, Powis G, Kozikowski AP. Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues Tetrahedron Letters. 43: 2835-2838. DOI: 10.1016/S0040-4039(02)00354-4 |
0.506 |
|
| 1999 |
Kozikowski AP, Simoni D, Roberti M, Rondanin R, Wang S, Du P, Johnson KM. Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity. Bioorganic & Medicinal Chemistry Letters. 9: 1831-6. PMID 10406650 DOI: 10.1016/S0960-894X(99)00273-5 |
0.461 |
|
| 1999 |
Ibarreta D, Duchén M, Ma D, Qiao L, Kozikowski AP, Etcheberrigaray R. Benzolactam (BL) enhances sAPP secretion in fibroblasts and in PC12 cells. Neuroreport. 10: 1035-40. PMID 10321481 DOI: 10.1097/00001756-199904060-00026 |
0.405 |
|
| 1999 |
Simoni D, Roberti M, Rondanin R, Kozikowski AP. Enantioselective deprotonation of the 8-oxabicyclo[3.2.1]octan-3-one: Synthesis of 8-oxa-norcocaines and 8-oxa-pseudonorcocaines Tetrahedron Letters. 40: 4425-4428. DOI: 10.1016/S0040-4039(99)00763-7 |
0.473 |
|
| 1998 |
Ma D, Ma Z, Kozikowski AP, Pshenichkin S, Wroblewski JT. Synthesis and biological evaluation of two analogues of (S)-alpha-methyl-3-carboxyphenylalanine. Bioorganic & Medicinal Chemistry Letters. 8: 2447-50. PMID 9873559 DOI: 10.1016/S0960-894X(98)00409-0 |
0.439 |
|
| 1997 |
Kozikowski AP, Kotoula M, Ma D, Boujrad N, Tückmantel W, Papadopoulos V. Synthesis and biology of a 7-nitro-2,1,3-benzoxadiazol-4-yl derivative of 2-phenylindole-3-acetamide: a fluorescent probe for the peripheral-type benzodiazepine receptor. Journal of Medicinal Chemistry. 40: 2435-9. PMID 9258348 DOI: 10.1021/Jm970220W |
0.409 |
|
| 1997 |
Kozikowski AP, Wang S, Ma D, Yao J, Ahmad S, Glazer RI, Bogi K, Acs P, Modarres S, Lewin NE, Blumberg PM. Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity. Journal of Medicinal Chemistry. 40: 1316-26. PMID 9135029 DOI: 10.1021/Jm960875H |
0.49 |
|
| 1996 |
Kozikowski AP, Simoni D, Manfredini S, Roberti M, Stoelwinder J. Synthesis of the 6- and 7-hydroxylated cocaines and pseudococaines Tetrahedron Letters. 37: 5333-5336. DOI: 10.1016/0040-4039(96)01123-9 |
0.444 |
|
| 1994 |
Kozikowski AP, Ma D, Du L, Lewin NE, Blumberg PM. A palladium catalyzed route to a benzofuran analogue of idolactam V (ILV): Effects on PKC isotype selectivity Pure and Applied Chemistry. 66: 2087-2090. DOI: 10.1351/Pac199466102087 |
0.47 |
|
| 1994 |
Kozikowski AP, Ma D, Du L, Lewin NE, Blumberg PM. Synthesis of the benzofuran analogue of ILV, a new protein kinase C (PKC) activator Bioorganic & Medicinal Chemistry Letters. 4: 637-640. DOI: 10.1016/S0960-894X(01)80169-4 |
0.463 |
|
| 1993 |
Kozikowski AP, Ma D, Pang YP, Shum P, Likic V, Mishra PK, Macura S, Basu A, Lazo JS, Ball RG. Synthesis, molecular modeling, 2-D NMR, and biological evaluation of ILV mimics as potential modulators of protein kinase C Journal of the American Chemical Society. 115: 3957-3965. DOI: 10.1021/Ja00063A015 |
0.464 |
|
| 1993 |
Malaska MJ, Fauq AH, Kozikowski AP, Aagaard PJ, McKinney M. Simplified analogs of himbacine displaying potent binding affinity for muscarinic receptors Bioorganic & Medicinal Chemistry Letters. 3: 1247-1252. DOI: 10.1016/S0960-894X(00)80325-X |
0.579 |
|
| 1992 |
Kozikowski AP, Roberti M, Xiang L, Bergmann JS, Callahan PM, Cunningham KA, Johnson KM. Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue. Journal of Medicinal Chemistry. 35: 4764-6. PMID 1469704 DOI: 10.1021/Jm00103A015 |
0.447 |
|
| 1992 |
Kozikowski AP, Ma D, Romeo E, Auta J, Papadopoulos V, Puia G, Costa E, Guidotti A. Synthesis of (2-Arylindol-3-yl)acetamides as Probes of Mitochondrial Steroidogenesis?A New Mechanism for GABAA Receptor Modulation Angewandte Chemie International Edition in English. 31: 1060-1062. DOI: 10.1002/Anie.199210601 |
0.402 |
|
| 1992 |
Kozikowski AP, Ma D, Romeo E, Auta J, Papadopoulos V, Puia G, Costa E, Guidotti A. Synthese von (2-Arylindol-3-yl)acetamiden als Sonden zur Untersuchung der mitochondrialen Steroidbildung - ein neuer Mechanismus für die GABAA-Rezeptormodulation Angewandte Chemie. 104: 1092-1094. DOI: 10.1002/Ange.19921040837 |
0.365 |
|
| 1991 |
Kozikowski AP, Ma D. Palladium catalyzed synthesis of annelated indoles Tetrahedron Letters. 32: 3317-3320. DOI: 10.1016/S0040-4039(00)92695-9 |
0.424 |
|
| 1985 |
Kozikowski AP, Ghosh AK. Methods for Pyranoannulation: An Approach to a New Class of Polyethers. The Journal of Organic Chemistry. 50: 3017-3019. PMID 31285634 DOI: 10.1002/Chin.198552215 |
0.478 |
|
| 1984 |
Kozikowski AP, Ghosh AK. Diastereofacial Selection in Nitrile Oxide Cycloaddition Reactions. The Anti-Directing Effect of an Allylic Oxygen and Some New Results on the Ring Metalation of Isoxazolines. A Synthesis of (±)-Blastmycinone. The Journal of Organic Chemistry. 49: 2762-2772. PMID 31527928 DOI: 10.1002/Chin.198451113 |
0.49 |
|
| 1983 |
Kozikowski AP, Ghosh AK. The Isoxazoline Route to α-Methylene Lactones. Tetrahedron Letters. 24: 2623-2626. PMID 31595093 DOI: 10.1016/S0040-4039(00)87961-7 |
0.472 |
|
| 1982 |
Kozikowski AP, Ghosh AK. Diastereoselection in Intermolecular Nitrile Oxide Cycloaddition (NOC) Reactions: Confirmation of the "Anti-Periplanar Effect" through a Simple Synthesis of 2-Deoxy-d-ribose. Journal of the American Chemical Society. 104: 5788-5789. PMID 31156251 DOI: 10.1002/Chin.198304355 |
0.476 |
|
| 1978 |
Corey E, Bock MG, Kozikowski A, Rao A, Floyd D, Lipshutz B. A key intermediate for the synthesis of maytansine and related antitumor agents Tetrahedron Letters. 19: 1051-1054. DOI: 10.1016/S0040-4039(01)85449-6 |
0.445 |
|
| 1977 |
Corey E, Wetter HF, Kozikowski A, Rama Rao A. Preparation of a benzenoid intermediate For use in the synthesis of Maytansine Tetrahedron Letters. 18: 777-778. DOI: 10.1016/S0040-4039(01)92752-2 |
0.445 |
|
| 1975 |
Corey EJ, Kozikowski AP. Bis(dimethylaluminum) 1,3-propanedithiolate-a useful reagent in the conversion of esters to unsaturated aldehydes and ketones Tetrahedron Letters. 16: 925-928. DOI: 10.1016/S0040-4039(00)72021-1 |
0.442 |
|
| 1975 |
Corey EJ, Kozikowski AP. 3-hydroxy-2-pyrone as a vinylketene equivalent for the synthesis of dihydrophenols and cyclohexenones Tetrahedron Letters. 16: 2389-2392. DOI: 10.1016/0040-4039(75)80019-0 |
0.456 |
|
| 1973 |
Dauben WG, Hart DJ, Ipaktschi J, Kozikowski AP. A facile synthesis of substituted conjugated cyclohexadienes Tetrahedron Letters. 14: 4425-4428. DOI: 10.1016/S0040-4039(01)87239-7 |
0.567 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2005 |
Jung M, Kozikowski A, Dritschilo A. Rational design and development of radiation-sensitizing histone deacetylase inhibitors Chemistry and Biodiversity. 2: 1452-1461. PMID 17191946 DOI: 10.1002/Cbdv.200590118 |
0.297 |
|
| 2016 |
Knox T, Lienlaf M, Perez P, Pabon M, Lee C, Cheng F, Sahakian E, Powers J, Deng S, Keiran S, Kozikowski A, Pinilla J, Sarnaik A, Seto E, Weber J, et al. Abstract 2331: HDAC6, new role as master regulator of PD-L1 and immune-related pathways Cancer Research. 76: 2331-2331. DOI: 10.1158/1538-7445.Am2016-2331 |
0.295 |
|
| 2005 |
Yu M, Tueckmantel W, Wang X, Zhu A, Kozikowski AP, Brownell AL. Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: Synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors Nuclear Medicine and Biology. 32: 631-640. PMID 16026710 DOI: 10.1016/J.Nucmedbio.2005.05.004 |
0.294 |
|
| 2016 |
Ugolkov A, Gaisina I, Zhang JS, Billadeau DD, White K, Kozikowski A, Jain S, Cristofanilli M, Giles F, O'Halloran T, Cryns VL, Mazar AP. GSK-3 inhibition overcomes chemoresistance in human breast cancer. Cancer Letters. PMID 27424289 DOI: 10.1016/J.Canlet.2016.07.006 |
0.293 |
|
| 2017 |
Knox T, Sahakian E, Nair J, Kim J, Banik D, Hadley M, Powers J, Cheng F, Shen S, Pinilla J, Weber J, Kozikowski A, Sotomayor E, Villagra A. Abstract 4055: Enhancing anti-PD-1 immune blockade in melanoma through selective inhibition of histone deacetylase 6 Cancer Research. 77: 4055-4055. DOI: 10.1158/1538-7445.Am2017-4055 |
0.293 |
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| 2016 |
Ugolkov A, Gaisina I, White K, Kozikowski A, O’Halloran T, Mazar A. Abstract 3078: GSK-3 inhibitor 9ING41 potentiates the antitumor effects of CPT-11 in human breast cancer Cancer Research. 76: 3078-3078. DOI: 10.1158/1538-7445.Am2016-3078 |
0.292 |
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| 2010 |
Kozikowski AP, Cho SJ, Jensen NH, Allen JA, Svennebring AM, Roth BL. HTS and rational drug design to generate a class of 5-HT(2C)-selective ligands for possible use in schizophrenia. Chemmedchem. 5: 1221-5. PMID 20533502 DOI: 10.1002/Cmdc.201000186 |
0.29 |
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| 2019 |
Alhadidy MM, Soliman AS, Tetlow AM, Kara B, Kozikowski A, Gordon MN, Morgan D. P4-039: A Novel Histone Deacetylase 6 (Hdac6) Inhibitor To Mitigate Tau Pathology In Alzheimer'S Disease Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.3698 |
0.29 |
|
| 2009 |
Kim KH, Gaisina I, Gallier F, Holzle D, Blond SY, Mesecar A, Kozikowski AP. Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl) maleimides as GSK-3β inhibitors Journal of Molecular Modeling. 15: 1463-1479. PMID 19440740 DOI: 10.1007/S00894-009-0498-X |
0.289 |
|
| 2006 |
Jayaprakash S, Iso Y, Wan B, Franzblau S, Kozikowski A. Cover Picture: Design, Synthesis, and SAR Studies of Mefloquine-Based Ligands as Potential Antituberculosis Agents (ChemMedChem 6/2006) Chemmedchem. 1: 577-577. DOI: 10.1002/Cmdc.200690018 |
0.287 |
|
| 2009 |
Kozikowski AP, Eaton JB, Bajjuri KM, Chellappan SK, Chen Y, Karadi S, He R, Caldarone B, Manzano M, Yuen PW, Lukas RJ. Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depression. Chemmedchem. 4: 1279-91. PMID 19569163 DOI: 10.1002/Cmdc.200900079 |
0.287 |
|
| 2017 |
Kozikowski AP, Onajole OK, Stec J, Dupont C, Viljoen A, Richard M, Chaira T, Lun S, Bishai WR, Raj VS, Ordway D, Kremer L. Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections. Journal of Medicinal Chemistry. PMID 28574259 DOI: 10.1021/Acs.Jmedchem.7B00582 |
0.286 |
|
| 2003 |
Wei ZL, Xiao Y, George C, Kellar KJ, Kozikowski AP. Functionalization of the alicyclic skeleton of epibatidine: synthesis and nicotinic acetylcholine receptor binding affinities of epibatidine analogues. Organic & Biomolecular Chemistry. 1: 3878-81. PMID 14664377 DOI: 10.1039/B308906A |
0.286 |
|
| 2013 |
Ugolkov A, Gaisina I, Malin D, Kulesza P, Kozikowski A, Cryns V, Mazar A. Abstract B068: Inhibition of GSK-3: A novel therapeutic approach for breast cancer treatment Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-B068 |
0.286 |
|
| 2006 |
Jayaprakash S, Iso Y, Wan B, Franzblau SG, Kozikowski AP. Erratum: Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents (ChemMedChem (2006) 1 (593-597)) Chemmedchem. 1. DOI: 10.1002/Cmdc.200690024 |
0.286 |
|
| 2006 |
Jayaprakash S, Iso Y, Wan B, Franzblau SG, Kozikowski AP. Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents Chemmedchem. 1: 593-597. PMID 16892398 DOI: 10.1002/Cmdc.200600010 |
0.286 |
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| 2018 |
Benoy V, Van Helleputte L, Prior R, d'Ydewalle C, Haeck W, Geens N, Scheveneels W, Schevenels B, Cader MZ, Talbot K, Kozikowski AP, Vanden Berghe P, Van Damme P, Robberecht W, Van Den Bosch L. HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease. Brain : a Journal of Neurology. PMID 29415205 DOI: 10.1093/Brain/Awx375 |
0.284 |
|
| 2002 |
Woolverton WL, Ranaldi R, Wang Z, Ordway GA, Paul IA, Petukhov P, Kozikowski A. Reinforcing strength of a novel dopamine transporter ligand: pharmacodynamic and pharmacokinetic mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 303: 211-7. PMID 12235253 DOI: 10.1124/Jpet.102.037812 |
0.284 |
|
| 2007 |
Kozikowski AP, Chellappan SK, Xiao Y, Bajjuri KM, Yuan H, Kellar KJ, Petukhov PA. Chemical medicine: novel 10-substituted cytisine derivatives with increased selectivity for alpha4beta2 nicotinic acetylcholine receptors. Chemmedchem. 2: 1157-61. PMID 17530728 DOI: 10.1002/Cmdc.200700073 |
0.284 |
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| 2013 |
Lwin T, Zhao X, Cheng F, Zhang X, Huang A, Shah B, Zhang Y, Moscinski LC, Choi YS, Kozikowski AP, Bradner JE, Dalton WS, Sotomayor E, Tao J. A microenvironment-mediated c-Myc/miR-548m/HDAC6 amplification loop in non-Hodgkin B cell lymphomas. The Journal of Clinical Investigation. 123: 4612-26. PMID 24216476 DOI: 10.1172/Jci64210 |
0.284 |
|
| 2019 |
Zhang G, McCorvy JD, Shen S, Cheng J, Roth BL, Kozikowski AP. Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT) receptor agonist without 5-HT agonism. European Journal of Medicinal Chemistry. 182: 111626. PMID 31445232 DOI: 10.1016/J.Ejmech.2019.111626 |
0.284 |
|
| 2016 |
Baumgart S, Chen NM, Zhang JS, Billadeau DD, Gaisina I, Kozikowski AP, Singh S, Fink D, Strobel P, Klindt C, Zhang L, Bamlet WR, Koenig A, Hessmann E, Gress T, et al. GSK-3β governs inflammation-induced NFATc2 signaling hubs to promote pancreatic cancer progression. Molecular Cancer Therapeutics. PMID 26823495 DOI: 10.1158/1535-7163.Mct-15-0309 |
0.284 |
|
| 2023 |
Ptacek J, Snajdr I, Schimer J, Kutil Z, Mikesova J, Baranova P, Havlinova B, Tueckmantel W, Majer P, Kozikowski A, Barinka C. Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells. International Journal of Molecular Sciences. 24. PMID 36902164 DOI: 10.3390/ijms24054720 |
0.282 |
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| 2017 |
Walz A, Ugolkov A, Chandra S, Kozikowski A, Carneiro BA, O'Halloran TV, Giles FJ, Billadeau DD, Mazar AP. Molecular Pathways: Revisiting Glycogen Synthase Kinase-3β as a target for the treatment of cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28053024 DOI: 10.1158/1078-0432.Ccr-15-2240 |
0.282 |
|
| 2005 |
Zhong C, Zhao X, Sarva J, Kozikowski A, Neale JH, Lyeth BG. NAAG peptidase inhibitor reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion TBI in rats. Journal of Neurotrauma. 22: 266-76. PMID 15716632 DOI: 10.1089/Neu.2005.22.266 |
0.282 |
|
| 2008 |
Yuan H, He R, Wan B, Wang Y, Pauli GF, Franzblau SG, Kozikowski AP. Modification of the side chain of micromolide, an anti-tuberculosis natural product Bioorganic and Medicinal Chemistry Letters. 18: 5311-5315. PMID 18774716 DOI: 10.1016/J.Bmcl.2008.08.027 |
0.28 |
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| 2020 |
Picci C, Wong VSC, Costa CJ, McKinnon MC, Goldberg DC, Swift M, Alam NM, Prusky GT, Shen S, Kozikowski AP, Willis DE, Langley B. HDAC6 inhibition promotes α-tubulin acetylation and ameliorates CMT2A peripheral neuropathy in mice. Experimental Neurology. 113281. PMID 32147437 DOI: 10.1016/J.Expneurol.2020.113281 |
0.278 |
|
| 2012 |
Bergman JA, Woan K, Perez-Villarroel P, Villagra A, Sotomayor EM, Kozikowski AP. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. Journal of Medicinal Chemistry. 55: 9891-9. PMID 23009203 DOI: 10.1021/Jm301098E |
0.278 |
|
| 2010 |
Hilliard T, Muehlbauer A, Gaisina I, Gaisin A, Gallier F, Kozikowski A, Burdette J. Novel Glycogen Synthase Kinase 3beta Inhibitors Induce Apoptosis in Ovarian Cancer. Biology of Reproduction. 83: 691-691. DOI: 10.1093/Biolreprod/83.S1.691 |
0.278 |
|
| 2009 |
Lilienkampf A, Jialin M, Baojie W, Yuehong W, Franzblau SG, Kozikowski AP. Structure-Activity relationships for a series of quinoline-based compounds active against replicating and nonreplicating mycobacterium tuberculosis Journal of Medicinal Chemistry. 52: 2109-2118. PMID 19271749 DOI: 10.1021/Jm900003C |
0.277 |
|
| 2014 |
Cheng F, Lienlaf M, Perez-Villarroel P, Wang HW, Lee C, Woan K, Woods D, Knox T, Bergman J, Pinilla-Ibarz J, Kozikowski A, Seto E, Sotomayor EM, Villagra A. Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells. Molecular Immunology. 60: 44-53. PMID 24747960 DOI: 10.1016/J.Molimm.2014.02.019 |
0.276 |
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| 2018 |
Nakajima R, Nováková Z, Tueckmantel W, Motlová L, Bařinka C, Kozikowski AP. 2-Aminoadipic Acid-C(O)-Glutamate Based Prostate-Specific Membrane Antigen Ligands for Potential Use as Theranostics. Acs Medicinal Chemistry Letters. 9: 1099-1104. PMID 30429952 DOI: 10.1021/Acsmedchemlett.8B00318 |
0.275 |
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| 2013 |
De Narvajas AAM, Gomez TS, Zhang JS, Mann AO, Taoda Y, Gorman JA, Herreros-Villanueva M, Gress TM, Ellenrieder V, Bujand L, Kim DH, Kozikowski AP, Koenig A, Billadeau DD. Epigenetic regulation of autophagy by the methyltransferase G9a Molecular and Cellular Biology. 33: 3983-3993. PMID 23918802 DOI: 10.1128/Mcb.00813-13 |
0.275 |
|
| 2007 |
Mao J, Wang Y, Wan B, Kozikowski AP, Franzblau SG. Design, synthesis, and pharmacological evaluation of mefloquine-based ligands as novel antituberculosis agents Chemmedchem. 2: 1624-1630. PMID 17680579 DOI: 10.1002/Cmdc.200700112 |
0.274 |
|
| 2010 |
Pieroni M, Lilienkampf A, Wang Y, Wan B, Cho S, Franzblau SG, Kozikowski AP. NOC chemistry for tuberculosis - Further investigations on the structure-activity relationships of antitubercular isoxazole-3-carboxylic acid ester derivatives Chemmedchem. 5: 1667-1672. PMID 20718072 DOI: 10.1002/Cmdc.201000169 |
0.273 |
|
| 2016 |
Budke B, Lv W, Kozikowski AP, Connell PP. Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy? Chemmedchem. PMID 27781374 DOI: 10.1002/Cmdc.201600426 |
0.272 |
|
| 2011 |
D'Ydewalle C, Krishnan J, Chiheb DM, Van Damme P, Irobi J, Kozikowski AP, Berghe PV, Timmerman V, Robberecht W, Van Den Bosch L. HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease Nature Medicine. 17: 968-974. PMID 21785432 DOI: 10.1038/Nm.2396 |
0.272 |
|
| 2011 |
Caldarone BJ, Wang D, Paterson NE, Manzano M, Fedolak A, Cavino K, Kwan M, Hanania T, Chellappan SK, Kozikowski AP, Olivier B, Picciotto MR, Ghavami A. Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380. Psychopharmacology. 217: 199-210. PMID 21487659 DOI: 10.1007/S00213-011-2271-Y |
0.272 |
|
| 2015 |
Winglee K, Lun S, Pieroni M, Kozikowski A, Bishai W. Mutation of Rv2887, a marR-Like gene, confers mycobacterium tuberculosis resistance to an imidazopyridine-based agent Antimicrobial Agents and Chemotherapy. 59: 6873-6881. DOI: 10.1128/Aac.01341-15 |
0.271 |
|
| 2020 |
Tavares MT, Kozikowski AP, Shen S. Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors. European Journal of Medicinal Chemistry. 209: 112887. PMID 33035922 DOI: 10.1016/j.ejmech.2020.112887 |
0.271 |
|
| 2005 |
Foss CA, Mease RC, Fan H, Wang Y, Ravert HT, Dannals RF, Olszewski RT, Heston WD, Kozikowski AP, Pomper MG. Radiolabeled small-molecule ligands for prostate-specific membrane antigen: in vivo imaging in experimental models of prostate cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 4022-8. PMID 15930336 DOI: 10.1158/1078-0432.Ccr-04-2690 |
0.269 |
|
| 2001 |
Wang S, Sakamuri S, Enyedy IJ, Kozikowski AP, Zaman WA, Johnson KM. Molecular modeling, structure--activity relationships and functional antagonism studies of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketones as a novel class of dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry. 9: 1753-64. PMID 11425577 DOI: 10.1016/S0968-0896(01)00090-6 |
0.267 |
|
| 2013 |
Onajole OK, Pieroni M, Tipparaju SK, Lun S, Stec J, Chen G, Gunosewoyo H, Guo H, Ammerman NC, Bishai WR, Kozikowski AP. Preliminary structure - Activity relationships and biological evaluation of novel antitubercular indolecarboxamide derivatives against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains Journal of Medicinal Chemistry. 56: 4093-4103. PMID 23611124 DOI: 10.1021/Jm4003878 |
0.266 |
|
| 2005 |
Wei J, Wu C, Lankin D, Gulrati A, Valyi-Nagy T, Cochran E, Pike VW, Kozikowski A, Wang Y. Development of novel amyloid imaging agents based upon thioflavin S. Current Alzheimer Research. 2: 109-14. PMID 15974905 DOI: 10.2174/1567205053585864 |
0.262 |
|
| 2017 |
Tavares MT, Shen S, Knox T, Hadley M, Kutil Z, Bařinka C, Villagra A, Kozikowski AP. Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models. Acs Medicinal Chemistry Letters. 8: 1031-1036. PMID 29057046 DOI: 10.1021/acsmedchemlett.7b00223 |
0.259 |
|
| 2009 |
Tang H, Wang XS, Huang XP, Roth BL, Butler KV, Kozikowski AP, Jung M, Tropsha A. Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation. Journal of Chemical Information and Modeling. 49: 461-76. PMID 19182860 DOI: 10.1021/Ci800366F |
0.258 |
|
| 2006 |
Saito O, Aoe T, Kozikowski A, Sarva J, Neale JH, Yamamoto T. Ketamine and N-acetylaspartylglutamate peptidase inhibitor exert analgesia in bone cancer pain. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 53: 891-8. PMID 16960267 DOI: 10.1007/Bf03022832 |
0.253 |
|
| 2002 |
Zhang A, Zhou G, Rong SB, Johnson KM, Zhang M, Kozikowski AP. Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors. Bioorganic & Medicinal Chemistry Letters. 12: 993-5. PMID 11909701 DOI: 10.1016/S0960-894X(02)00103-8 |
0.252 |
|
| 2008 |
Sanchez-Pernaute R, Wang JQ, Kuruppu D, Cao L, Tueckmantel W, Kozikowski A, Isacson O, Brownell AL. Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates. Neuroimage. 42: 248-51. PMID 18501638 DOI: 10.1016/J.Neuroimage.2008.04.170 |
0.251 |
|
| 2013 |
Yuan Y, Yu LF, Qiu X, Kozikowski AP, Van Breemen RB. Pharmacokinetics and brain penetration of LF-3-88, (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol), a selective α4β2-nAChR partial agonist and promising antidepressant Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 912: 38-42. PMID 23246847 DOI: 10.1016/J.Jchromb.2012.11.011 |
0.251 |
|
| 2006 |
Makarewicz D, Gadamski R, Ziembowicz A, Kozikowski AP, Wroblewski JT, Lazarewicz JW. Neuroprotective effects of the agonist of metabotropic glutamate receptors ABHxD-I in two animal models of cerebral ischaemia. Resuscitation. 68: 119-26. PMID 16325990 DOI: 10.1016/J.Resuscitation.2005.05.018 |
0.249 |
|
| 2007 |
Mao J, Wan B, Wang Y, Franzblau SG, Kozikowski AP. HTS, chemical hybridization, and drug design identify a chemically unique antituberculosis agent-coupling serendipity and rational approaches to drug discovery. Chemmedchem. 2: 811-3. PMID 17455191 DOI: 10.1002/Cmdc.200700048 |
0.249 |
|
| 2002 |
Zhang A, Zhou G, Hoepping A, Mukhopadhyaya J, Johnson KM, Zhang M, Kozikowski AP. Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors. Journal of Medicinal Chemistry. 45: 1930-41. PMID 11960503 DOI: 10.1021/jm0105373 |
0.249 |
|
| 2008 |
Butler KV, Kozikowski AP. Chemical origins of isoform selectivity in histone deacetylase inhibitors Current Pharmaceutical Design. 14: 505-528. PMID 18336297 DOI: 10.2174/138161208783885353 |
0.249 |
|
| 2013 |
Afanador GA, Muench SP, McPhillie M, Fomovska A, Schön A, Zhou Y, Cheng G, Stec J, Freundlich JS, Shieh HM, Anderson JW, Jacobus DP, Fidock DA, Kozikowski AP, Fishwick CW, et al. Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay. Biochemistry. 52: 9155-66. PMID 24295325 DOI: 10.1021/Bi400945Y |
0.248 |
|
| 2011 |
Kozikowski AP. On the path from chemistry to neuroscience: Early explorations in chemical medicine under the mentorship of Dr. Erminio Costa, a neuroscientist with a big brain and a bigger heart Pharmacological Research. 64: 327-329. PMID 21708253 DOI: 10.1016/J.Phrs.2011.05.025 |
0.246 |
|
| 2009 |
LaPointe NE, Morfini G, Pigino G, Gaisina IN, Kozikowski AP, Binder LI, Brady ST. The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity. Journal of Neuroscience Research. 87: 440-51. PMID 18798283 DOI: 10.1002/Jnr.21850 |
0.244 |
|
| 2018 |
Porter NJ, Shen S, Barinka C, Kozikowski AP, Christianson DW. Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor. Acs Medicinal Chemistry Letters. 9: 1301-1305. PMID 30613344 DOI: 10.2210/Pdb6Mr5/Pdb |
0.244 |
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| 2023 |
Motlová L, Šnajdr I, Kutil Z, Andris E, Ptáček J, Novotná A, Nováková Z, Havlínová B, Tueckmantel W, Dráberová H, Majer P, Schutkowski M, Kozikowski A, Rulíšek L, Bařinka C. Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6). Acs Chemical Biology. PMID 37392419 DOI: 10.1021/acschembio.3c00212 |
0.241 |
|
| 2011 |
Pieroni M, Tipparaju SK, Lun S, Song Y, Sturm AW, Bishai WR, Kozikowski AP. Pyrido[1,2-a]benzimidazole-Based Agents Active Against Tuberculosis (TB), Multidrug-Resistant (MDR) TB and Extensively Drug-Resistant (XDR) TB Chemmedchem. 6: 334-342. PMID 21259445 DOI: 10.1002/Cmdc.201000490 |
0.241 |
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| 2019 |
Shen S, Hadley M, Ustinova K, Pavlíček J, Knox T, Noonepalle S, Tavares MT, Zimprich CA, Zhang G, Robers MB, Barinka C, Kozikowski A, Villagra A. Discovery of a New Isoxazole-3-hydroxamate Based Histone Deacetylase 6 Inhibitor SS-208 with Anti-tumor Activity in Syngeneic Melanoma Mouse Models. Journal of Medicinal Chemistry. PMID 31414801 DOI: 10.1021/acs.jmedchem.9b00946 |
0.241 |
|
| 2010 |
Liu J, Eaton JB, Caldarone B, Lukas RJ, Kozikowski AP. Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as α4β2-nicotinic acetylcholine receptor-selective partial agonists. Journal of Medicinal Chemistry. 53: 6973-85. PMID 20822184 DOI: 10.1021/jm100765u |
0.237 |
|
| 2012 |
Yu LF, Eaton JB, Fedolak A, Zhang HK, Hanania T, Brunner D, Lukas RJ, Kozikowski AP. Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II. Journal of Medicinal Chemistry. 55: 9998-10009. PMID 23092294 DOI: 10.1021/Jm301177J |
0.237 |
|
| 2007 |
Niemitz M, Laatikainen R, Chen SN, Kieps R, Kozikowski AP, Pauli GF. Complete 1H NMR spectral fingerprint of huperzine A Magnetic Resonance in Chemistry. 45: 878-882. PMID 17729231 DOI: 10.1002/Mrc.2061 |
0.237 |
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| 2019 |
Shen S, Kozikowski AP. A patent review of histone deacetylase 6 inhibitors in neurodegenerative diseases (2014-2019). Expert Opinion On Therapeutic Patents. PMID 31865813 DOI: 10.1080/13543776.2019.1708901 |
0.236 |
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| 2019 |
Budke B, Tueckmantel W, Miles K, Kozikowski AP, Connell PP. Optimization of Drug Candidates that Inhibit the D-loop Activity of RAD51. Chemmedchem. PMID 30957434 DOI: 10.1002/Cmdc.201900075 |
0.232 |
|
| 2012 |
Cho SY, Gage KL, Mease RC, Senthamizhchelvan S, Holt DP, Jeffrey-Kwanisai A, Endres CJ, Dannals RF, Sgouros G, Lodge M, Eisenberger MA, Rodriguez R, Carducci MA, Rojas C, Slusher BS, ... Kozikowski AP, et al. Biodistribution, tumor detection, and radiation dosimetry of 18F-DCFBC, a low-molecular-weight inhibitor of prostate-specific membrane antigen, in patients with metastatic prostate cancer. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 53: 1883-91. PMID 23203246 DOI: 10.2967/Jnumed.112.104661 |
0.23 |
|
| 2003 |
Kozikowski AP, Nowak I, Petukhov PA, Etcheberrigaray R, Mohamed A, Tan M, Lewin N, Hennings H, Pearce LL, Blumberg PM. New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα Journal of Medicinal Chemistry. 46: 364-373. PMID 12540236 DOI: 10.1021/Jm020350R |
0.229 |
|
| 1998 |
Kozikowski AP, Araldi GL, Prakash KRC, Zhang M, Johnson KM. Synthesis and biological properties of new 2β-alkyl- and 2β-aryl-3- (substituted phenyl)tropane derivatives: Stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters Journal of Medicinal Chemistry. 41: 4973-4982. PMID 9836615 DOI: 10.1021/jm9802564 |
0.228 |
|
| 1998 |
Kozikowski AP, Araldi GL, Boja J, Meil WM, Johnson KM, Flippen-Anderson JL, George C, Saiah E. Chemistry and pharmacology of the piperidine-based analogues of cocaine. Identification of potent DAT inhibitors lacking the tropane skeleton. Journal of Medicinal Chemistry. 41: 1962-9. PMID 9599245 DOI: 10.1021/Jm980028+ |
0.228 |
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| 2020 |
Noonepalle S, Shen S, Ptacek J, Tavares MT, Zhang G, Stransky J, Pavlicek J, Ferreira GM, Hadley M, Pelaez G, Bařinka C, Kozikowski AP, Villagra A. Rational Design of Suprastat, a Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models. Journal of Medicinal Chemistry. PMID 32815366 DOI: 10.1021/acs.jmedchem.0c00567 |
0.225 |
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| 2013 |
Zhang HK, Yu LF, Eaton JB, Whiteaker P, Onajole OK, Hanania T, Brunner D, Lukas RJ, Kozikowski AP. Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II. Journal of Medicinal Chemistry. 56: 5495-504. PMID 23734673 DOI: 10.1021/Jm400510U |
0.223 |
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| 2004 |
Komander D, Kular GS, Schüttelkopf AW, Deak M, Prakash KRC, Bain J, Elliott M, Garrido-Franco M, Kozikowski AP, Alessi DR, Van Aalten DMF. Interactions of LY333531 and Other Bisindolyl Maleimide Inhibitors with PDK1 Structure. 12: 215-226. PMID 14962382 DOI: 10.1016/J.Str.2004.01.005 |
0.223 |
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| 2001 |
Sakamuri S, Enyedy IJ, Kozikowski AP, Zaman WA, Johnson KM, Wang S. Pharmacophore-based discovery, synthesis, and biological evaluation of 4-phenyl-1-arylalkyl piperidines as dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. 11: 495-500. PMID 11229756 DOI: 10.1016/S0960-894X(00)00703-4 |
0.222 |
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| 2021 |
Shen S, Picci C, Ustinova K, Benoy V, Kutil Z, Zhang G, Tavares MT, Pavlíček J, Zimprich CA, Robers MB, Van Den Bosch L, Bařinka C, Langley B, Kozikowski AP. Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model. Journal of Medicinal Chemistry. PMID 33830764 DOI: 10.1021/acs.jmedchem.0c02210 |
0.221 |
|
| 2008 |
Guilarte TR, Hammoud DA, McGlothan JL, Caffo BS, Foss CA, Kozikowski AP, Pomper MG. Dysregulation of glutamate carboxypeptidase II in psychiatric disease Schizophrenia Research. 99: 324-332. PMID 18191545 DOI: 10.1016/J.Schres.2007.11.013 |
0.22 |
|
| 2004 |
Wei ZL, Petukhov PA, Bizik F, Teixeira JC, Mercola M, Volpe EA, Glazer RI, Willson TM, Kozikowski AP. Isoxazolyl-serine-based agonists of peroxisome proliferator-activated receptor: design, synthesis, and effects on cardiomyocyte differentiation. Journal of the American Chemical Society. 126: 16714-5. PMID 15612696 DOI: 10.1021/Ja046386L |
0.22 |
|
| 2001 |
Tamiz AP, Bandyopadhyay BC, Zhang J, Flippen-Anderson JL, Zhang M, Wang CZ, Johnson KM, Tella S, Kozikowski AP. Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors. Journal of Medicinal Chemistry. 44: 1615-22. PMID 11334571 DOI: 10.1021/jm000552s |
0.22 |
|
| 2004 |
Micale N, Vairagoundar R, Yakovlev AG, Kozikowski AP. Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3 Journal of Medicinal Chemistry. 47: 6455-6458. PMID 15588079 DOI: 10.1021/jm049248f |
0.22 |
|
| 2006 |
Chellappan SK, Xiao Y, Tueckmantel W, Kellar KJ, Kozikowski AP. Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. Journal of Medicinal Chemistry. 49: 2673-6. PMID 16640326 DOI: 10.1021/Jm051196M |
0.219 |
|
| 2020 |
Shen S, Svoboda M, Zhang G, Cavasin MA, Motlova L, McKinsey TA, Eubanks JH, Bařinka C, Kozikowski AP. Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor. Acs Medicinal Chemistry Letters. 11: 706-712. PMID 32435374 DOI: 10.1021/acsmedchemlett.9b00560 |
0.218 |
|
| 2007 |
Kozikowski AP, Chellappan SK, Henderson D, Fulton R, Giboureau N, Xiao Y, Wei ZL, Guilloteau D, Emond P, Dolle F, Kellar KJ, Kassiou M. Acetylenic pyridines for use in PET imaging of nicotinic receptors. Chemmedchem. 2: 54-7. PMID 17096450 DOI: 10.1002/Cmdc.200600220 |
0.217 |
|
| 2009 |
Huang Q, Mao J, Wan B, Wang Y, Brun R, Franzblau SG, Kozikowski AP. Searching for new cures for tuberculosis: Design, synthesis, and biological evaluation of 2-methylbenzothiazoles Journal of Medicinal Chemistry. 52: 6757-6767. PMID 19817445 DOI: 10.1021/Jm901112F |
0.217 |
|
| 2006 |
Kozikowski AP, Roth B, Tropsha A. Why academic drug discovery makes sense. Science (New York, N.Y.). 313: 1235-6. PMID 16946051 DOI: 10.1126/Science.313.5791.1235C |
0.214 |
|
| 2012 |
Chen PC, Gaisina IN, El-Khodor BF, Ramboz S, Makhortova NR, Rubin LL, Kozikowski AP. Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of Δ7 SMA KO Mouse Model of Spinal Muscular Atrophy. Acs Chemical Neuroscience. 3: 5-11. PMID 22348181 DOI: 10.1021/Cn200085Z |
0.214 |
|
| 2001 |
Enyedy IJ, Zaman WA, Sakamuri S, Kozikowski AP, Johnson KM, Wang S. Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. 11: 1113-8. PMID 11354356 DOI: 10.1016/S0960-894X(01)00132-9 |
0.214 |
|
| 1997 |
Tückmantel W, Kozikowski AP, Wang S, Pshenichkin S, Wroblewski JT. Synthesis, molecular modeling, and biology of the 1-benzyl derivative of APDC - an apparent mGluR6 selective ligand Bioorganic and Medicinal Chemistry Letters. 7: 601-606. DOI: 10.1016/S0960-894X(97)00068-1 |
0.21 |
|
| 2019 |
Lun S, Tasneen R, Chaira T, Stec J, Onajole OK, Yang TJ, Cooper CB, Mdluli K, Converse PJ, Nuermberger EL, Raj VS, Kozikowski A, Bishai WR. Advancing the therapeutic potential of indoleamides for tuberculosis. Antimicrobial Agents and Chemotherapy. PMID 31010860 DOI: 10.1128/Aac.00343-19 |
0.206 |
|
| 2001 |
Petukhov PA, Zhang M, Johnson KJ, Tella SR, Kozikowski AP. SAR studies of piperidine-based analogues of cocaine. Part 3: Oxadiazoles Bioorganic and Medicinal Chemistry Letters. 11: 2079-2083. PMID 11514143 DOI: 10.1016/S0960-894X(01)00379-1 |
0.204 |
|
| 1997 |
Kozikowski AP, Qiao L, Tückmantel W, Powis G. Synthesis of 1D-3-deoxy- and -2,3-dideoxyphosphatidylinositol Tetrahedron. 53: 14903-14914. DOI: 10.1016/S0040-4020(97)10003-5 |
0.204 |
|
| 2009 |
Mao J, Yuan H, Wang Y, Wan B, Pieroni M, Huang Q, Van Breemen RB, Kozikowski AP, Franzblau SG. From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters Journal of Medicinal Chemistry. 52: 6966-6978. PMID 19863050 DOI: 10.1021/Jm900340A |
0.203 |
|
| 1998 |
Kozikowski AP, Steensma D, Araldi GL, Tückmantel W, Wang S, Pshenichkin S, Surina E, Wroblewski JT. Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist. Journal of Medicinal Chemistry. 41: 1641-50. PMID 9572889 DOI: 10.1021/Jm970719Q |
0.203 |
|
| 2001 |
Qiao L, Zhao LY, Rong SB, Wu XW, Wang S, Fujii T, Kazanietz MG, Rauser L, Savage J, Roth BL, Flippen-Anderson J, Kozikowski AP. Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth. Bioorganic & Medicinal Chemistry Letters. 11: 955-9. PMID 11327599 DOI: 10.1016/S0960-894X(01)00097-X |
0.203 |
|
| 2008 |
Tipparaju SK, Joyasawal S, Pieroni M, Kaiser M, Brun R, Kozikowski AP. In pursuit of natural product leads: Synthesis and biological evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4- carboxylic acid (A-33853) and its analogues: Discovery of N-(2-benzoxazol-2- ylphenyl)benzamides as novel antileishmanial chemotypes Journal of Medicinal Chemistry. 51: 7344-7347. PMID 18989953 DOI: 10.1021/jm801241n |
0.202 |
|
| 2012 |
Yu LF, Tückmantel W, Eaton JB, Caldarone B, Fedolak A, Hanania T, Brunner D, Lukas RJ, Kozikowski AP. Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity. Journal of Medicinal Chemistry. 55: 812-23. PMID 22148173 DOI: 10.1021/Jm201301H |
0.201 |
|
| 2020 |
Tan L, Zhou Q, Yan W, Sun J, Kozikowski AP, Zhao S, Huang XP, Cheng J. Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands. Journal of Medicinal Chemistry. PMID 32282200 DOI: 10.1021/Acs.Jmedchem.9B01835 |
0.201 |
|
| 2012 |
Zhang H, Tückmantel W, Eaton JB, Yuen PW, Yu LF, Bajjuri KM, Fedolak A, Wang D, Ghavami A, Caldarone B, Paterson NE, Lowe DA, Brunner D, Lukas RJ, Kozikowski AP. Chemistry and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Journal of Medicinal Chemistry. 55: 717-24. PMID 22171543 DOI: 10.1021/Jm201157C |
0.2 |
|
| 2019 |
Suri A, Bailey AW, Tavares MT, Gunosewoyo H, Dyer CP, Grupenmacher AT, Piper DR, Horton RA, Tomita T, Kozikowski AP, Roy SM, Sredni ST. Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer. International Journal of Molecular Sciences. 20. PMID 31035676 DOI: 10.3390/ijms20092112 |
0.199 |
|
| 2006 |
Mach UR, Lewin NE, Blumberg PM, Kozikowski AP. Synthesis and pharmacological evaluation of 8- and 9-substituted benzolactam-V8 derivatives as potent ligands for protein kinase C, a therapeutic target for Alzheimer's disease Chemmedchem. 1: 307-314. PMID 16892365 DOI: 10.1002/Cmdc.200500068 |
0.199 |
|
| 2008 |
Barinka C, Byun Y, Dusich CL, Banerjee SR, Chen Y, Castanares M, Kozikowski AP, Mease RC, Pomper MG, Lubkowski J. Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: Structural characterization Journal of Medicinal Chemistry. 51: 7737-7743. PMID 19053759 DOI: 10.1021/Jm800765E |
0.196 |
|
| 2019 |
Kutil Z, Mikešová J, Zessin M, Meleshin M, Nováková Z, Alquicer G, Kozikowski A, Sippl W, Bařinka C, Schutkowski M. Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors. Acs Omega. 4: 19895-19904. PMID 31788622 DOI: 10.1021/acsomega.9b02808 |
0.195 |
|
| 2002 |
Prakash KR, Tang Y, Kozikowski AP, Flippen-Anderson JL, Knoblach SM, Faden AI. Synthesis and biological activity of novel neuroprotective diketopiperazines. Bioorganic & Medicinal Chemistry. 10: 3043-8. PMID 12110327 DOI: 10.1016/S0968-0896(02)00132-3 |
0.195 |
|
| 2011 |
Kozikowski AP, Neale JH. Effective Collaborations: How to Protect Yourself, Your Collaborators, and Your Data Chemmedchem. 6: 411-414. PMID 21360815 DOI: 10.1002/Cmdc.201000529 |
0.195 |
|
| 2002 |
Rajendran V, Saxena A, Doctor BP, Kozikowski AP. Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B Bioorganic and Medicinal Chemistry Letters. 12: 1521-1523. PMID 12031333 DOI: 10.1016/S0960-894X(02)00204-4 |
0.194 |
|
| 2004 |
Castillo SS, Brognard J, Petukhov PA, Zhang C, Tsurutani J, Granville CA, Li M, Jung M, West KA, Gills JG, Kozikowski AP, Dennis PA. Preferential Inhibition of Akt and Killing of Akt-Dependent Cancer Cells by Rationally Designed Phosphatidylinositol Ether Lipid Analogues Cancer Research. 64: 2782-2792. PMID 15087394 DOI: 10.1158/0008-5472.Can-03-1530 |
0.194 |
|
| 1992 |
Kozikowski AP, Fauq AH, Miller JH, McKinney M. Alzheimer's therapy: an approach to novel muscarinic ligands based upon the naturally occurring alkaloid himbacine Bioorganic and Medicinal Chemistry Letters. 2: 797-802. DOI: 10.1016/S0960-894X(00)80534-X |
0.193 |
|
| 1979 |
Kozikowski AP, Schmiesing R. Synthesis of the 'supposed' cannivonine: A constituent of new brunswick cranberry leaves Journal of the Chemical Society, Chemical Communications. 106-108. DOI: 10.1039/C39790000106 |
0.192 |
|
| 2012 |
Lilienkampf A, Pieroni M, Franzblau SG, Bishai WR, Kozikowski AP. Derivatives of 3-isoxazolecarboxylic acid esters - a potent and selective compound class against replicating and nonreplicating Mycobacterium tuberculosis Current Topics in Medicinal Chemistry. 12: 729-734. PMID 22283815 DOI: 10.2174/156802612799984544 |
0.191 |
|
| 1993 |
Kozikowski AP, Powis G, Gallegos A, Tückmantel W. Synthesis of D-3-deoxy-3-phosphonomethyl-myo-inositol and its dimethyl ester - compounds of use in studying the ptdins-3′-kinase signalling pathway Bioorganic and Medicinal Chemistry Letters. 3: 1323-1326. DOI: 10.1016/S0960-894X(00)80340-6 |
0.19 |
|
| 2003 |
Sridhar J, Wei ZL, Nowak I, Lewin NE, Ayres JA, Pearce LV, Blumberg PM, Kozikowski AP. New bivalent PKC ligands linked by a carbon spacer: Enhancement in binding affinity Journal of Medicinal Chemistry. 46: 4196-4204. PMID 12954072 DOI: 10.1021/Jm0302041 |
0.188 |
|
| 2009 |
Cho SJ, Jensen NH, Kurome T, Kadari S, Manzano ML, Malberg JE, Caldarone B, Roth BL, Kozikowski AP. Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action. Journal of Medicinal Chemistry. 52: 1885-902. PMID 19284718 DOI: 10.1021/jm801354e |
0.187 |
|
| 1998 |
Qiao L, Wang S, George C, Lewin NE, Blumberg PM, Kozikowski AP. Structure-Based Design of a New Class of Protein Kinase C Modulators Journal of the American Chemical Society. 120: 6629-6630. DOI: 10.1021/Ja980513U |
0.186 |
|
| 2003 |
Wei ZL, Kozikowski AP. A Short and Efficient Synthesis of the Pharmacological Research Tool GW501516 for the Peroxisome Proliferator-Activated Receptor δ Journal of Organic Chemistry. 68: 9116-9118. PMID 14604391 DOI: 10.1021/jo035140g |
0.186 |
|
| 2004 |
Quirante J, Vila X, Bonjoch J, Kozikowski AP, Johnson KM. 2,3-disubstituted 6-azabicyclo[3.2.1]octanes as novel dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry. 12: 1383-91. PMID 15018911 DOI: 10.1016/j.bmc.2004.01.019 |
0.186 |
|
| 2008 |
Wroblewska B, Ramadan E, Bacich DJ, O'Keefe DS, Heston WDW, Bukhari N, Wegorzewska I, Bzdega T, Wroblewski JT, Kozikowski A, Yamamoto T, Neale JH. Probing the functions of NAAG via NAAG peptidases and MGLUR3 Journal of Neurochemistry. 81: 69-70. DOI: 10.1046/J.1471-4159.2002.00052.X |
0.186 |
|
| 2018 |
Kozikowski A, Shen S, Pardo M, Tavares MT, Szarics D, Benoy V, Zimprich CA, Kutil Z, Zhang G, Barinka C, Robers MB, Van Den Bosch L, Eubanks JH, Jope RS. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome. Acs Chemical Neuroscience. PMID 30511829 DOI: 10.1021/Acschemneuro.8B00600 |
0.186 |
|
| 2011 |
Liu J, Yu LF, Eaton JB, Caldarone B, Cavino K, Ruiz C, Terry M, Fedolak A, Wang D, Ghavami A, Lowe DA, Brunner D, Lukas RJ, Kozikowski AP. Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depression. Journal of Medicinal Chemistry. 54: 7280-8. PMID 21905669 DOI: 10.1021/Jm200855B |
0.184 |
|
| 2012 |
Zhang HK, Eaton JB, Yu LF, Nys M, Mazzolari A, van Elk R, Smit AB, Alexandrov V, Hanania T, Sabath E, Fedolak A, Brunner D, Lukas RJ, Vistoli G, Ulens C, ... Kozikowski AP, et al. Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands. Journal of Medicinal Chemistry. 55: 8028-37. PMID 22928944 DOI: 10.1021/Jm3008739 |
0.183 |
|
| 1996 |
Kozikowski AP, Liao Y, Tückmantel W, Wang S, Pshenichkin S, Surin A, Thomsen C, Wroblewski JT. Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA) Bioorganic and Medicinal Chemistry Letters. 6: 2559-2564. DOI: 10.1016/0960-894X(96)00464-7 |
0.182 |
|
| 2007 |
Gills JJ, Castillo SS, Zhang C, Petukhov PA, Memmott RM, Hollingshead M, Warfel N, Han J, Kozikowski AP, Dennis PA. Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38α, through MKK3/6-independent and -dependent mechanisms Journal of Biological Chemistry. 282: 27020-27029. PMID 17631503 DOI: 10.1074/Jbc.M701108200 |
0.181 |
|
| 2003 |
Sakamuri S, Enyedy IJ, Zaman WA, Tella SR, Kozikowski AP, Flippen-Anderson JL, Farkas T, Johnson KM, Wang S. 2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry. 11: 1123-36. PMID 12614900 DOI: 10.1016/S0968-0896(02)00450-9 |
0.179 |
|
| 2020 |
Raynaud C, Daher W, Roquet-Banères F, Johansen MD, Stec J, Onajole OK, Ordway D, Kozikowski AP, Kremer L. Synergistic interactions of indole-2-carboxamides and β-lactam antibiotics against . Antimicrobial Agents and Chemotherapy. PMID 32041716 DOI: 10.1128/AAC.02548-19 |
0.179 |
|
| 2006 |
Kozikowski AP, Zhao L, Zhang A, Wang CZ, Flippen-Anderson J, Johnson KM. Structural remodeling of cocaine: design and synthesis of trisubstituted cyclopropanes as selective serotonin reuptake inhibitors. Chemmedchem. 1: 58-65. PMID 16892336 DOI: 10.1002/cmdc.200500016 |
0.179 |
|
| 1977 |
Kozikowski AP, Hasan NM. Oxazoles in organic chemistry. Synthesis of the antitumor agent ellipticine Journal of Organic Chemistry. 42: 2039-2040. PMID 864547 DOI: 10.1021/JO00431A059 |
0.174 |
|
| 1981 |
Kozikowski AP, Sugiyama K, Springer JP. Studies directed toward the total synthesis of the rubradirin antibiotics. 2. Synthesis of the unique morpholinonaphthoquinone chromophore: a lesson in Diels-Alder regiocontrol by diene substituent selection The Journal of Organic Chemistry. 46: 2426-2428. DOI: 10.1021/JO00324A054 |
0.173 |
|
| 2002 |
Rong SB, Zhang J, Neale JH, Wroblewski JT, Wang S, Kozikowski AP. Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors. Journal of Medicinal Chemistry. 45: 4140-52. PMID 12213057 DOI: 10.1021/Jm010561G |
0.173 |
|
| 1990 |
Kozikowski AP, Wu JP. Synthesis of fluorine-containing isosteres of sphingosine as inactivators of protein kinase C Tetrahedron Letters. 31: 4309-4312. DOI: 10.1016/S0040-4039(00)97608-1 |
0.173 |
|
| 2001 |
Kozikowski AP, Tückmantel W, Hu Y. Studies in polyphenol chemistry and bioactivity. 3. Stereocontrolled synthesis of epicatechin-4α,8-epicatechin, an unnatural isomer of the B-type procyanidins Journal of Organic Chemistry. 66: 1287-1296. PMID 11312959 DOI: 10.1021/jo001462y |
0.172 |
|
| 2008 |
Pibiri F, Kozikowski AP, Pinna G, Auta J, Kadriu B, Costa E, Guidotti A. The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 14169-74. PMID 18784370 DOI: 10.1073/pnas.0807172105 |
0.172 |
|
| 2004 |
Yuan H, Kozikowski AP, Petukhov PA. CoMFA study of piperidine analogues of cocaine at the dopamine transporter: Exploring the binding mode of the 3α-substituent of the piperidine ring using pharmacophore-based flexible alignment Journal of Medicinal Chemistry. 47: 6137-6143. PMID 15566285 DOI: 10.1021/Jm049544S |
0.172 |
|
| 2008 |
Memmott RM, Gills JJ, Hollingshead M, Powers MC, Chen Z, Kemp B, Kozikowski A, Dennis PA. Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells. Cancer Research. 68: 580-8. PMID 18199555 DOI: 10.1158/0008-5472.CAN-07-3091 |
0.171 |
|
| 2007 |
Tang L, Chen Y, Chen Z, Blumberg PM, Kozikowski AP, Wang ZJ. Antinociceptive pharmacology of N-(4-chlorobenzyl)-N'-(4-hydroxy-3-iodo-5-methoxybenzyl) thiourea, a high-affinity competitive antagonist of the transient receptor potential vanilloid 1 receptor. The Journal of Pharmacology and Experimental Therapeutics. 321: 791-8. PMID 17312187 DOI: 10.1124/Jpet.106.117572 |
0.171 |
|
| 2001 |
Rajendran V, Rong SB, Saxena A, Doctor BP, Kozikowski AP. Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B Tetrahedron Letters. 42: 5359-5361. DOI: 10.1016/S0040-4039(01)01008-5 |
0.17 |
|
| 1998 |
Kozikowski AP, Steensma D, Varasi M, Pshenichkin S, Surina E, Wroblewski JT. alpha-substituted quisqualic acid analogs: new metabotropic glutamate receptor group II selective antagonists. Bioorganic & Medicinal Chemistry Letters. 8: 447-52. PMID 9871596 DOI: 10.1016/S0960-894X(98)00052-3 |
0.169 |
|
| 2000 |
Tamiz AP, Zhang J, Zhang M, Wang CZ, Johnson KM, Kozikowski AP. Application of the bivalent ligand approach to the design of novel dimeric serotonin reuptake inhibitors [4] Journal of the American Chemical Society. 122: 5393-5394. DOI: 10.1021/ja000199f |
0.169 |
|
| 1992 |
Kozikowski AP, Yamada F, Pang YP. Synthesis and 2D NMR analysis of a cyclopropane containing analogue of huperzine A Tetrahedron Letters. 33: 2653-2656. DOI: 10.1016/S0040-4039(00)79049-6 |
0.168 |
|
| 2003 |
Kozikowski AP, Tückmantel W, Böttcher G, Romanczyk LJ. Studies in polyphenol chemistry and bioactivity. 4. Synthesis of trimeric, tetrameric, pentameric, and higher oligomeric epicatechin-derived procyanidins having all-4β,8-interflavan connectivity and their inhibition of cancer cell growth through cell cycle arrest Journal of Organic Chemistry. 68: 1641-1658. PMID 12608775 DOI: 10.1021/jo020393f |
0.168 |
|
| 2010 |
KOZIKOWSKI AP, XIA Y, REDDY ER, TUECKMANTEL W, HANIN I, TANG XC. ChemInform Abstract: Synthesis of Huperzine A (I) and Its Analogues and Their Anticholinesterase Activity. Cheminform. 22: no-no. DOI: 10.1002/CHIN.199152303 |
0.167 |
|
| 2019 |
Ding L, Madamsetty VS, Kiers S, Alekhina O, Ugolkov A, Dube J, Zhang Y, Zhang JS, Wang E, Dutta SK, Schmitt DM, Giles FJ, Kozikowski AP, Mazar AP, Mukhopadhyay D, et al. Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31533931 DOI: 10.1158/1078-0432.Ccr-19-0799 |
0.166 |
|
| 2003 |
Meuillet EJ, Mahadevan D, Vankayalapati H, Berggren M, Williams R, Coon A, Kozikowski AP, Powis G. Specific inhibition of the Akt1 pleckstrin homology domain by D-3-deoxy-phosphatidyl-myo-inositol analogues. Molecular Cancer Therapeutics. 2: 389-99. PMID 12700283 |
0.164 |
|
| 2000 |
Conti P, Kozikowski AP. New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist Tetrahedron Letters. 41: 4053-4056. DOI: 10.1016/S0040-4039(00)00588-8 |
0.163 |
|
| 2010 |
Guo S, Song Y, Huang Q, Yuan H, Wan B, Wang Y, He R, Beconi MG, Franzblau SG, Kozikowski AP. Identification, synthesis, and pharmacological evaluation of tetrahydroindazole based ligands as novel antituberculosis agents Journal of Medicinal Chemistry. 53: 649-659. PMID 20000470 DOI: 10.1021/Jm901235P |
0.163 |
|
| 2005 |
Ukairo OT, Bondi CD, Newman AH, Kulkarni SS, Kozikowski AP, Pan S, Surratt CK. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue Journal of Pharmacology and Experimental Therapeutics. 314: 575-583. PMID 15879005 DOI: 10.1124/Jpet.105.085829 |
0.162 |
|
| 1990 |
Kozikowski AP, Pang Y. Synthesis and Chemical Resolution of a Novel Class of Rigid 1-(1-Phenylcyclohexyl)-iperidine(PCP) Analogues Synlett. 1990: 58-63. DOI: 10.1055/S-1990-20989 |
0.16 |
|
| 2000 |
Zhao L, Qiao L, Rong S, Kozikowski AP. The synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones as novel protein kinase C modulators Tetrahedron Letters. 41: 8711-8715. DOI: 10.1016/S0040-4039(00)01561-6 |
0.16 |
|
| 2019 |
Raynaud C, Daher W, Johansen M, Roquet-Baneres F, Blaise M, Onajole OK, Kozikowski A, Herrmann JL, Dziadek J, Gobis K, Kremer L. Active benzimidazole derivatives targeting the MmpL3 transporter in . Acs Infectious Diseases. PMID 31860799 DOI: 10.1021/acsinfecdis.9b00389 |
0.158 |
|
| 2001 |
Trzcińska M, Pimentel P, Stellar JR, Hanson RN, Choi SW, Elmaleh DR, Zhang J, Prakash KR, Tamiz AP, Kozikowski AP, Johnson KM, Smith MP, Babich JW. Novel monoamine transporter ligands reduce cocaine-induced enhancement of brain stimulation reward. Pharmacology, Biochemistry, and Behavior. 68: 171-80. PMID 11274722 DOI: 10.1016/S0091-3057(00)00454-8 |
0.158 |
|
| 2002 |
Petukhov PA, Zhang J, Kozikowski AP, Wang CZ, Ye YP, Johnson KM, Tella SR. SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement. Journal of Medicinal Chemistry. 45: 3161-70. PMID 12109901 DOI: 10.1021/Jm0200153 |
0.155 |
|
| 2005 |
Yin Y, Russell RG, Dettin LE, Bai R, Wei ZL, Kozikowski AP, Kopelovich L, Kopleovich L, Glazer RI. Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis. Cancer Research. 65: 3950-7. PMID 15867396 DOI: 10.1158/0008-5472.Can-04-3990 |
0.153 |
|
| 1999 |
Kozikowski AP, Araldi GL, Tückmantel W, Pshenichkin S, Surina E, Wroblewski JT. 1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties. Bioorganic & Medicinal Chemistry Letters. 9: 1721-6. PMID 10397508 DOI: 10.1016/S0960-894X(99)00266-8 |
0.153 |
|
| 1984 |
Kozikowski AP, Park PU. Synthesis of 2-substituted .DELTA.3-piperidines: the nitrogen analog of the Ferrier rearrangement. An approach to streptazolin The Journal of Organic Chemistry. 49: 1674-1676. DOI: 10.1021/JO00183A044 |
0.153 |
|
| 1989 |
Xia Y, Reddy ER, Kozikowski AP. Synthesis of the benzenoid analogue of the chinese nootropic agent huperzine a Tetrahedron Letters. 30: 3291-3294. DOI: 10.1016/S0040-4039(00)99224-4 |
0.152 |
|
| 1992 |
Kozikowski AP, Tückmantel W, Powis G. Synthesis and Biological Activity ofD-3-Deoxy-3-Fluorophosphatidylinositol—A New Direction in the Design of non-DNA Targeted Anticancer Agents Angewandte Chemie International Edition in English. 31: 1379-1381. DOI: 10.1002/ANIE.199213791 |
0.152 |
|
| 2002 |
Pomper MG, Musachio JL, Zhang J, Scheffel U, Zhou Y, Hilton J, Maini A, Dannals RF, Wong DF, Kozikowski AP. 11C-MCG: Synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase) Molecular Imaging. 1: 96-101. PMID 12920850 DOI: 10.1162/153535002320162750 |
0.151 |
|
| 2019 |
Knox T, Sahakian E, Banik D, Hadley M, Palmer E, Noonepalle S, Kim J, Powers J, Gracia-Hernandez M, Oliveira V, Cheng F, Chen J, Barinka C, Pinilla-Ibarz J, Lee NH, ... Kozikowski A, et al. Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells. Scientific Reports. 9: 6136. PMID 30992475 DOI: 10.1038/s41598-019-42237-3 |
0.151 |
|
| 1998 |
Kozikowski AP, Araldi GL, Flippen-Anderson J, George C, Pshenichkin S, Surina E, Wroblewski J. Synthesis and metabotropic glutamate receptor activity of a 2- aminobicyclo[3.2.0]Heptane-2,5-dicarboxylic acid, a molecule possessing an extended glutamate conformation Bioorganic and Medicinal Chemistry Letters. 8: 925-930. PMID 9871513 DOI: 10.1016/S0960-894X(98)00146-2 |
0.15 |
|
| 2006 |
Micale N, Kozikowski AP, Ettari R, Grasso S, Zappalà M, Jeong JJ, Kumar A, Hanspal M, Chishti AH. Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents Journal of Medicinal Chemistry. 49: 3064-3067. PMID 16722625 DOI: 10.1021/jm060405f |
0.15 |
|
| 1999 |
Faden AI, Fox GB, Fan L, Araldi GL, Qiao L, Wang S, Kozikowski AP. Novel TRH analog improves motor and cognitive recovery after traumatic brain injury in rodents American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 277: R1196-R1204. PMID 10516262 DOI: 10.1152/Ajpregu.1999.277.4.R1196 |
0.149 |
|
| 2006 |
Iso Y, Kozikowski AP. Synthesis of 4-arylethynyl-2-methyloxazole derivatives as mGluR5 antagonists for use in the treatment of drug abuse Synthesis. 243-246. DOI: 10.1055/s-2005-918503 |
0.149 |
|
| 2010 |
KOZIKOWSKI AP, TUECKMANTEL W, POWIS G. ChemInform Abstract: Synthesis and Biological Activity of D-3-Deoxy-3- fluorophosphatidylinositol - A New Direction in the Design of Non-DNA Targeted Anticancer Agents. Cheminform. 24: no-no. DOI: 10.1002/CHIN.199305286 |
0.148 |
|
| 1985 |
Kozikowski AP, MaloneyHuss KE. A model study for the synthesis of the hexahydrobenzofuran fragment of the milbemycins and avermectins Tetrahedron Letters. 26: 5759-5762. DOI: 10.1016/S0040-4039(00)98918-4 |
0.147 |
|
| 2009 |
Kozikowski AP, Tückmantel W. Methods for Synthesizing the Cocoa-Derived Oligomeric Epi-Catechins - Observations on the Anticancer Activity of the Cocoa Polyphenols Recent Advances in Polyphenol Research. 1: 88-112. DOI: 10.1002/9781444302400.ch4 |
0.147 |
|
| 2005 |
Wei ZL, Xiao Y, Yuan H, Baydyuk M, Petukhov PA, Musachio JL, Kellar KJ, Kozikowski AP. Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. Journal of Medicinal Chemistry. 48: 1721-4. PMID 15771418 DOI: 10.1021/Jm0492406 |
0.144 |
|
| 1986 |
KOZIKOWSKI AP, JUNG SH. ChemInform Abstract: A Useful Approach to Tricyclic Compounds and Medium Ring Diketones through the Phosphoniosilylation Reaction. Chemischer Informationsdienst. 17. DOI: 10.1002/chin.198649094 |
0.144 |
|
| 1996 |
Kozikowski AP, Ding Q, Spiegel S. Synthesis of erythro-ω-aminosphingosine and preparation of an affinity column for sphingosine kinase purification Tetrahedron Letters. 37: 3279-3282. DOI: 10.1016/0040-4039(96)00575-8 |
0.144 |
|
| 2015 |
Cheng J, Giguere PM, Lv W, Roth BL, Kozikowski AP. Design and synthesis of (2-(5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a selective serotonin 2C agonist This Letter is dedicated to the lasting memory of Harry H. Wasserman, a connoisseur of heterocycles Tetrahedron Letters. 56: 3420-3422. DOI: 10.1016/j.tetlet.2015.01.060 |
0.143 |
|
| 2012 |
Yu LF, Zhang HK, Gunosewoyo H, Kozikowski AP. From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design. Acs Medicinal Chemistry Letters. 3: 1054-1058. PMID 23641311 DOI: 10.1021/ml3002715 |
0.143 |
|
| 1990 |
Kozikowski AP, Yamada F, Tang XC, Hanin I. Synthesis and biological evaluation of (±)-Z-huperzine A Tetrahedron Letters. 31: 6159-6162. DOI: 10.1016/S0040-4039(00)97013-8 |
0.142 |
|
| 1995 |
Pang YP, Zaidi J, Kozikowski AP, Cusack B, Richelson E. Rational design of novel neurotensin mimetics: discovery of a pharmacologically unprecedented agent exhibiting concentration-dependent dual effects as antagonist and full agonist. Journal of Computer-Aided Molecular Design. 8: 433-40. PMID 7815094 DOI: 10.1007/BF00125377 |
0.142 |
|
| 1986 |
Kozikowski AP, Jung SH. A useful approach to tricyclic compounds and medium ring diketones through the phosphoniosilylation reaction Tetrahedron Letters. 27: 3227-3230. DOI: 10.1016/S0040-4039(00)84760-7 |
0.141 |
|
| 2003 |
Faden AI, Knoblach SM, Cernak I, Fan L, Vink R, Araldi GL, Fricke ST, Roth BL, Kozikowski AP. Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 23: 342-54. PMID 12621309 DOI: 10.1097/01.Wcb.0000046143.31247.Fd |
0.14 |
|
| 1980 |
Kozikowski AP, Chen Y. Ketene thioacetal route to .gamma.-lactones. Effect of carbonyl hardness on reaction-site selectivity and a unique preparation of 3-methyl-5-phenyl-2(5H)-furanone The Journal of Organic Chemistry. 45: 2236-2239. DOI: 10.1021/JO01299A039 |
0.139 |
|
| 2019 |
Cao R, Islamoglu H, Teskey G, Gyurjian K, Abrahem R, Onajole OK, Lun S, Bishai W, Kozikowski AP, Fraix MP, Sathananthan A, Zhong L, Stec J, Venketaraman V. The preclinical candidate indole-2-carboxamide improves immune responses to Mycobacterium tuberculosis infection in healthy subjects and individuals with type 2 diabetes. International Microbiology : the Official Journal of the Spanish Society For Microbiology. PMID 31218537 DOI: 10.1007/S10123-019-00086-0 |
0.139 |
|
| 1985 |
Kozikowski AP, Uk Park P. Total synthesis of streptazolin - an application of the aza-analogue of the ferrier rearrangement Journal of the American Chemical Society. 107: 1763-1765. DOI: 10.1021/JA00292A054 |
0.138 |
|
| 2010 |
KOZIKOWSKI AP, MA D. ChemInform Abstract: Palladium-Catalyzed Synthesis of Anellated Indoles. Cheminform. 23: no-no. DOI: 10.1002/CHIN.199215167 |
0.138 |
|
| 1988 |
Kozikowski AP, Jung SH, Springer JP. A [(4 + 2) + (3 + 2)] approach to a forskolin intermediate; a further understanding of π-facial selection in Diels-Alder reactions Journal of the Chemical Society, Chemical Communications. 167-169. DOI: 10.1039/C39880000167 |
0.137 |
|
| 2006 |
Jayaprakash S, Wang X, Heston WD, Kozikowski AP. Design and synthesis of a PSMA inhibitor-doxorubicin conjugate for targeted prostate cancer therapy Chemmedchem. 1: 299-302. PMID 16892363 DOI: 10.1002/cmdc.200500044 |
0.137 |
|
| 2001 |
Zhang J, Flippen-Anderson JL, Kozikowski AP. A tandem Michael addition ring-closure route to the metabotropic receptor ligand α-(hydroxymethyl)glutamic acid and its γ-alkylated derivatives Journal of Organic Chemistry. 66: 7555-7559. PMID 11681981 DOI: 10.1021/jo010626n |
0.137 |
|
| 2003 |
Wei ZL, George C, Kozikowski AP. Synthesis of 5-endo-, 5-exo-, 6-endo- and 6-exo-hydroxylated analogues of epibatidine Tetrahedron Letters. 44: 3847-3850. DOI: 10.1016/S0040-4039(03)00737-8 |
0.136 |
|
| 2000 |
Hu Y, Meuillet EJ, Qiao L, Berggren MM, Powis G, Kozikowski AP. Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid Tetrahedron Letters. 41: 7415-7418. DOI: 10.1016/S0040-4039(00)01186-2 |
0.135 |
|
| 2000 |
Kozikowski AP, Tückmantel W, George C. Studies in polyphenol chemistry and bioactivity. 2. Establishment of interflavan linkage regio- and stereochemistry by oxidative degradation of an O-alkylated derivative of procyanidin B2 to (R)-(-)-2,4-diphenylbutyric acid Journal of Organic Chemistry. 65: 5371-5381. PMID 10993368 DOI: 10.1021/Jo000485+ |
0.134 |
|
| 1993 |
Favaron M, Manev RM, Candeo P, Arban R, Gabellini N, Kozikowski AP, Manev H. Trans-azetidine-2,4-dicarboxylic acid activates neuronal metabotropic receptors. Neuroreport. 4: 967-70. PMID 8369491 DOI: 10.1097/00001756-199307000-00033 |
0.134 |
|
| 1977 |
Kozikowski AP, Floyd WC, Kuniak MP. 1,3-Diethoxycarbonylallene: An active dienophile and ethoxycarbonylketen equivalent in the synthesis of antibiotic C-nucleosides Journal of the Chemical Society, Chemical Communications. 582-583. DOI: 10.1039/C39770000582 |
0.134 |
|
| 1997 |
Kozikowski AP, Araldi GL, Ball RG. Dipolar Cycloaddition Route to Diverse Analogues of Cocaine: The 6- and 7-Substituted 3-Phenyltropanes. The Journal of Organic Chemistry. 62: 503-509. PMID 11671441 DOI: 10.1021/jo961957g |
0.134 |
|
| 1983 |
Kozikowski AP, Schmiesing RJ. Synthesis of an alleged constituent of New Brunswick cranberry leaves: the so-called cannivonine The Journal of Organic Chemistry. 48: 1000-1007. DOI: 10.1021/JO00155A014 |
0.133 |
|
| 1980 |
Kozikowski AP, Sugiyama K, Springer JP. An approach to the construction of the aromatic portions of naphthomycin and the rubradirins - nucleophilic additions to unsymmetrically substituted naphthoquinones Tetrahedron Letters. 21: 3257-3260. DOI: 10.1016/S0040-4039(00)78661-8 |
0.133 |
|
| 1981 |
Kozikowski AP, Sugiyama K, Huie E. Studies directed toward the total synthesis of the rubradirin antibiotics. 4. A new Diels-Alder-Claisen effective diene Tetrahedron Letters. 22: 3381-3384. DOI: 10.1016/S0040-4039(01)81911-0 |
0.133 |
|
| 2001 |
Maaser K, Höpfner M, Jansen A, Weisinger G, Gavish M, Kozikowski AP, Weizman A, Carayon P, Riecken EO, Zeitz M, Scherübl H. Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. British Journal of Cancer. 85: 1771-80. PMID 11742501 DOI: 10.1054/bjoc.2001.2181 |
0.132 |
|
| 1978 |
Kozikowski AP, Floyd WC. Borohydride induced cleavage of azo derivatives of β-ketoesters. A useful variant of the Japp-Klingemann reaction for C-nucleoside synthesis. Tetrahedron Letters. 19: 19-22. DOI: 10.1016/S0040-4039(01)88971-1 |
0.132 |
|
| 1998 |
Qiao L, Nan F, Kunkel M, Gallegos A, Powis G, Kozikowski AP. 3-Deoxyl-D-myo-inositol 1-phosphate, 1-phosphate, and ether lipid analogues as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth Journal of Medicinal Chemistry. 41: 3303-3306. PMID 9719581 DOI: 10.1021/jm980254j |
0.132 |
|
| 2019 |
Knox T, Sahakian E, Banik D, Hadley M, Palmer E, Noonepalle S, Kim J, Powers J, Gracia-Hernandez M, Oliveira V, Cheng F, Chen J, Barinka C, Pinilla-Ibarz J, Lee NH, ... Kozikowski A, et al. Author Correction: Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells. Scientific Reports. 9: 14824. PMID 31597938 DOI: 10.1038/S41598-019-51403-6 |
0.131 |
|
| 2004 |
Etcheberrigaray R, Tan M, Dewachter I, Kuipéri C, Van der Auwera I, Wera S, Qiao L, Bank B, Nelson TJ, Kozikowski AP, Van Leuven F, Alkon DL. Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 11141-6. PMID 15263077 DOI: 10.1073/pnas.0403921101 |
0.13 |
|
| 1990 |
Xiang L, Kozikowski AP. Synthetic Studies on the Stemona Alkaloids; Stereochemical Course of PhSe+-Induced Seven-Membered Ring Formation Synlett. 1990: 279-281. DOI: 10.1055/S-1990-21065 |
0.13 |
|
| 2021 |
Ding L, Madamsetty VS, Kiers S, Alekhina O, Ugolkov A, Dube J, Zhang Y, Zhang JS, Wang E, Dutta SK, Schmitt DM, Giles FJ, Kozikowski AP, Mazar AP, Mukhopadhyay D, et al. Correction: Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-mediated DNA Damage Response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 27: 4128. PMID 34261773 DOI: 10.1158/1078-0432.CCR-21-2114 |
0.129 |
|
| 2005 |
Carón RW, Yacoub A, Li M, Zhu X, Mitchell C, Hong Y, Hawkins W, Sasazuki T, Shirasawa S, Kozikowski AP, Dennis PA, Hagan MP, Grant S, Dent P. Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. Molecular Cancer Therapeutics. 4: 257-70. PMID 15713897 |
0.129 |
|
| 2016 |
Lv W, Budke B, Kozikowski AP, Connell PP. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. International Journal of Radiation Oncology, Biology, Physics. 96: S16-S17. PMID 27675672 DOI: 10.1016/j.ijrobp.2016.06.053 |
0.129 |
|
| 2015 |
Winglee K, Lun S, Pieroni M, Kozikowski A, Bishai W. Mutation of Rv2887, a marR-like gene, confers Mycobacterium tuberculosis resistance to an imidazopyridine-based agent. Antimicrobial Agents and Chemotherapy. 59: 6873-81. PMID 26303802 DOI: 10.1128/AAC.01341-15 |
0.129 |
|
| 1985 |
Kozikowski AP, Ames A. Dimethylaluminum methaneselenolate-a useful reagent for the preparation of selenoesters. A new friedel-crafts acylation procedure promoted by Cu(I) Tetrahedron. 41: 4821-4834. DOI: 10.1016/S0040-4020(01)96721-3 |
0.127 |
|
| 2003 |
Yu M, Någren K, Chen YI, Livni E, Elmaleh D, Kozikowski A, Wang X, Jokivarsi K, Brownell AL. Radiolabeling and biodistribution of methyl 2-(methoxycarbonyl)-2-(methylamino) bicyclo [2.1.1] - hexane -5-carboxylate, a potential neuroprotective drug Life Sciences. 73: 1577-1585. PMID 12865097 DOI: 10.1016/S0024-3205(03)00482-X |
0.127 |
|
| 1984 |
Kozikowski AP, Greco MN. Total synthesis of the clavicipitic acids by an intramolecular azide cycloaddition strategy The Journal of Organic Chemistry. 49: 2310-2314. DOI: 10.1021/JO00187A002 |
0.126 |
|
| 2004 |
Tóth A, Blumberg PM, Chen Z, Kozikowski AP. Design of a High-Affinity Competitive Antagonist of the Vanilloid Receptor Selective for the Calcium Entry-Linked Receptor Population Molecular Pharmacology. 65: 282-291. PMID 14742669 DOI: 10.1124/Mol.65.2.282 |
0.126 |
|
| 2004 |
Wei ZL, Xiao Y, Kellar KJ, Kozikowski AP. Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors. Bioorganic & Medicinal Chemistry Letters. 14: 1855-8. PMID 15050615 DOI: 10.1016/J.Bmcl.2003.10.071 |
0.125 |
|
| 2001 |
Mukhopadhyaya JK, Kozikowski AP, Grajkowska E, Pshenichkin S, Wroblewski JT. Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors. Bioorganic & Medicinal Chemistry Letters. 11: 1919-24. PMID 11459661 DOI: 10.1016/S0960-894X(01)00329-8 |
0.123 |
|
| 1980 |
Kozikowski AP, Sugiyama K. Studies directed toward the total synthesis of the rubradirin antibiotics. 3. Diels-alder reactions of unsymmetrically substituted quinones-a confirmation of structure Tetrahedron Letters. 21: 4597-4600. DOI: 10.1016/0040-4039(80)80083-9 |
0.123 |
|
| 1984 |
Kozikowski AP, Sorgi KL. Use of the anomeric allylation reaction in natural products synthesis - a stereocontrolled synthesis of methyl deoxypseudomonate B Tetrahedron Letters. 25: 2085-2088. DOI: 10.1016/S0040-4039(01)81167-9 |
0.123 |
|
| 2009 |
Kozikowski AP. Use in the Synthesis of Non-heterocycles Comprehensive Heterocyclic Chemistry. 1: 413-491. DOI: 10.1016/B978-008096519-2.00016-3 |
0.123 |
|
| 2003 |
Wei ZL, Petukhov PA, Xiao Y, Tückmantel W, George C, Kellar KJ, Kozikowski AP. Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues. Journal of Medicinal Chemistry. 46: 921-4. PMID 12620069 DOI: 10.1021/Jm025613W |
0.122 |
|
| 1981 |
Kozikowski AP, Ames A. Total synthesis of the C-nucleoside dl-showdomycin by a Diels-Alder, retrograde Dieckmann strategy Journal of the American Chemical Society. 103: 3923-3924. DOI: 10.1021/JA00403A052 |
0.122 |
|
| 2001 |
Sakamuri S, Kozikowski AP. Synthesis of 7-methoxybenzolactam-V8 using a diastereoselective Strecker synthesis Chemical Communications. 475-476. |
0.122 |
|
| 2011 |
Huang Q, He R, Kozikowski AP. Stereochemistry at the forefront in the design and discovery of novel anti-tuberculosis agents Current Topics in Medicinal Chemistry. 11: 810-818. PMID 21291395 DOI: 10.2174/156802611795165205 |
0.121 |
|
| 2009 |
Maresca KP, Hillier SM, Femia FJ, Keith D, Barone C, Joyal JL, Zimmerman CN, Kozikowski AP, Barrett JA, Eckelman WC, Babich JW. A series of halogenated heterodimeric inhibitors of prostate specific membrane antigen (PSMA) as radiolabeled probes for targeting prostate cancer. Journal of Medicinal Chemistry. 52: 347-57. PMID 19111054 DOI: 10.1021/Jm800994J |
0.121 |
|
| 1988 |
Kozikowski AP, Okita M, Kobayashi M, Floss HG. Probing ergot alkaloid biosynthesis: synthesis and feeding of a proposed intermediate along the biosynthetic pathway. A new amidomalonate for tryptophan elaboration The Journal of Organic Chemistry. 53: 863-869. DOI: 10.1021/JO00239A034 |
0.12 |
|
| 1989 |
Kozikowski AP, Tückmantel W, Krueger K. Synthesis of a biotin conjugate of the PCP analogue "metaphit" for potential use in NMDA/PCP receptor isolation Tetrahedron Letters. 30: 4613-4616. DOI: 10.1016/S0040-4039(01)80756-5 |
0.119 |
|
| 1980 |
Kozikowski AP, Greco MN. Total synthesis of the unique indole alkaloid chuangxinmycin. Application of nitro group displacement reactions in organic synthesis Journal of the American Chemical Society. 102: 1165-1166. DOI: 10.1021/JA00523A044 |
0.118 |
|
| 1981 |
Kozikowski AP, Chen YY. Intramolecular nitrile oxide cycloaddition (INOC) reactions in the indole series. 2. Total synthesis of racemic and optically active paliclavine and 5-epi-paliclavine The Journal of Organic Chemistry. 46: 5248-5250. DOI: 10.1021/JO00338A049 |
0.118 |
|
| 2006 |
Xiao Y, Fan H, Musachio JL, Wei ZL, Chellappan SK, Kozikowski AP, Kellar KJ. Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them. Molecular Pharmacology. 70: 1454-60. PMID 16857741 DOI: 10.1124/Mol.106.027318 |
0.117 |
|
| 1982 |
Kozikowski AP, Greco MN. Intramolecular azide cycloaddition (IAC) reactions in the indole series - an approach to clavicipitic acid Tetrahedron Letters. 23: 2005-2008. DOI: 10.1016/S0040-4039(00)87245-7 |
0.117 |
|
| 2002 |
Pomper MG, Musachio JL, Zhang J, Scheffel U, Zhou Y, Hilton J, Maini A, Dannals RF, Wong DF, Kozikowski AP. 11
C-MCG: Synthesis, Uptake Selectivity, and Primate PET of a Probe for Glutamate Carboxypeptidase II (NAALADase) Molecular Imaging. 1: 153535002002021. DOI: 10.1162/15353500200202109 |
0.117 |
|
| 2001 |
Rong SB, Hu Y, Enyedy I, Powis G, Meuillet EJ, Wu X, Wang R, Wang S, Kozikowski AP. Molecular modeling studies of the Akt PH domain and its interaction with phosphoinositides. Journal of Medicinal Chemistry. 44: 898-908. PMID 11300871 DOI: 10.1021/Jm000493I |
0.115 |
|
| 1990 |
W. Shum P, Kozikowski AP. A convenient method for the synthesis of unsymmetrical 3,4-disubstituted pyrroles Tetrahedron Letters. 31: 6785-6788. DOI: 10.1016/S0040-4039(00)97171-5 |
0.115 |
|
| 1982 |
Kozikowski AP, Stein PD. The INOC route to carbocyclics: a formal total synthesis of (.+-.)-sarkomycin Journal of the American Chemical Society. 104: 4023-4024. DOI: 10.1021/JA00378A049 |
0.115 |
|
| 1982 |
KOZIKOWSKI AP, STEIN PD. ChemInform Abstract: THE INOC ROUTE TO CARBOCYCLICS: A FORMAL TOTAL SYNTHESIS OF (.+-.)-SARKOMYCIN Chemischer Informationsdienst. 13. DOI: 10.1002/chin.198243177 |
0.113 |
|
| 1980 |
Kozikowski AP, Schmiesing RJ, Sorgi KL. Total synthesis of pseudomonic acid C: application of the alkoxyselenation reaction in organic synthesis Journal of the American Chemical Society. 102: 6577-6580. DOI: 10.1021/JA00541A044 |
0.111 |
|
| 1985 |
Kozikowski AP, Li CS. A nitrile oxide based entry to 2,3-dihydropyran-4-ones. Synthesis of a protected version "compactin lactone" in racemic and optically active forms The Journal of Organic Chemistry. 50: 778-785. DOI: 10.1021/JO00206A010 |
0.11 |
|
| 1981 |
Kozikowski AP, Schmiesing RJ, Sorgi KL. The conversion of methyl pseudomonate C to pseudomonic acid A Tetrahedron Letters. 22: 2059-2062. DOI: 10.1016/S0040-4039(01)93276-9 |
0.109 |
|
| 2000 |
Belmant C, Espinosa E, Halary F, Tang Y, Peyrat MA, Sicard H, Kozikowski A, Buelow R, Poupot R, Bonneville M, Fournié JJ. A chemical basis for selective recognition of nonpeptide antigens by human delta T cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 1669-70. PMID 10973912 DOI: 10.1096/fj.99-0909fje |
0.109 |
|
| 1985 |
KOZIKOWSKI AP, LI C. ChemInform Abstract: A NITRILE OXIDE BASED ENTRY TO 2,3-DIHYDROPYRAN-4-ONES. SYNTHESIS OF A PROTECTED VERSION “COMPACTIN LACTONE” IN RACEMIC AND OPTICALLY ACTIVE FORMS Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198532183 |
0.109 |
|
| 2009 |
Pieroni M, Lilienkampf A, Baojie W, Yuehong W, Franzblau SG, Kozikowski AP. Synthesis, biological evaluation, and structure-activity relationships for 5-[(E)-2-arylethenyl]-3-isoxazolecarboxylic acid alkyl ester derivatives as valuable antitubercular chemotypes Journal of Medicinal Chemistry. 52: 6287-6296. PMID 19757815 DOI: 10.1021/Jm900513A |
0.108 |
|
| 1996 |
Fauq AH, Zaidi JH, Wilcox RA, Varvel G, Nahorski SR, Kozikowski AP, Erneux C. Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate Tetrahedron Letters. 37: 1917-1920. DOI: 10.1016/0040-4039(96)00169-4 |
0.107 |
|
| 1994 |
Pang YP, Kozikowski AP. Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies Journal of Computer-Aided Molecular Design. 8: 669-681. PMID 7738603 DOI: 10.1007/BF00124014 |
0.104 |
|
| 2003 |
Kozikowski AP, Johnson KM, Deschaux O, Bandyopadhyay BC, Araldi GL, Carmona G, Munzar P, Smith MP, Balster RL, Beardsley PM, Tella SR. Mixed cocaine agonist/antagonist properties of (+)-methyl 4beta-(4-chlorophenyl)-1-methylpiperidine-3alpha-carboxylate, a piperidine-based analog of cocaine. The Journal of Pharmacology and Experimental Therapeutics. 305: 143-50. PMID 12649362 DOI: 10.1124/Jpet.102.046318 |
0.104 |
|
| 1983 |
Kozikowski AP, Mugrage BB, Wang BC, Xu Zb. The INOC approach to the hydroazulenone ring system - a potential entry tot he guaianolides and pseudoguaianolides Tetrahedron Letters. 24: 3705-3708. DOI: 10.1016/S0040-4039(00)94514-3 |
0.104 |
|
| 1989 |
Sato K, Kozikowski AP. Construction of optically pure tryptophans from serine derived aziridine-2-carboxylates Tetrahedron Letters. 30: 4073-4076. DOI: 10.1016/S0040-4039(00)99325-0 |
0.104 |
|
| 1994 |
Siliprandi R, Lipartiti M, Fadda E, Arban R, Kozikowski AP, Manev H. A derivative of a rigid glutamate analog protects the retina from excitotoxicity. Neuroreport. 5: 1227-9. PMID 7919170 DOI: 10.1097/00001756-199406020-00017 |
0.103 |
|
| 1990 |
Kozikowski AP, Park PU. Synthesis of streptazolin: use of the aza-Ferrier reaction in conjunction with the INOC process to deliver a unique but sensitive natural product The Journal of Organic Chemistry. 55: 4668-4682. DOI: 10.1021/JO00302A036 |
0.103 |
|
| 2017 |
Viljoen A, Herrmann JL, Onajole OK, Stec J, Kozikowski AP, Kremer L. Controlling Extra- and Intramacrophagic Mycobacterium abscessus by Targeting Mycolic Acid Transport. Frontiers in Cellular and Infection Microbiology. 7: 388. PMID 28920054 DOI: 10.3389/fcimb.2017.00388 |
0.102 |
|
| 1994 |
Kozikowski AP, Powis G, Fauq AH, Tuckmantel W, Gallegos A. Synthesis and Biological Activity of the D-3-Deoxy-3-fluoro and D-3-Chloro-3-deoxy Analogs of Phosphatidylinositol The Journal of Organic Chemistry. 59: 963-971. DOI: 10.1021/JO00084A010 |
0.102 |
|
| 2014 |
Yu LF, Zhang HK, Caldarone BJ, Eaton JB, Lukas RJ, Kozikowski AP. Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. Journal of Medicinal Chemistry. 57: 8204-23. PMID 24901260 DOI: 10.1021/Jm401937A |
0.102 |
|
| 2008 |
Mease RC, Dusich CL, Foss CA, Ravert HT, Dannals RF, Seidel J, Prideaux A, Fox JJ, Sgouros G, Kozikowski AP, Pomper MG. N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl-L- cysteine, [18F]DCFBC: A new Imaging probe for prostate cancer Clinical Cancer Research. 14: 3036-3043. PMID 18483369 DOI: 10.1158/1078-0432.Ccr-07-1517 |
0.102 |
|
| 2009 |
Valette H, Xiao Y, Peyronneau MA, Damont A, Kozikowski AP, Wei ZL, Kassiou M, Kellar KJ, Dollé F, Bottlaender M. 18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors--in vitro binding properties and PET studies in baboons. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 50: 1349-55. PMID 19652217 DOI: 10.2967/jnumed.108.061374 |
0.101 |
|
| 1988 |
Park Pu, Kozikowski AP. Oxidation of isoxazolines by peracids - a useful route to β-hydroxy ketones and acylated diols Tetrahedron Letters. 29: 6703-6706. DOI: 10.1016/S0040-4039(00)82433-8 |
0.101 |
|
| 1978 |
Kozikowski AP, Ames A. Dimethylaluminum methylselenolate: a remarkable reagent for the preparation of active acyl-transfer agents The Journal of Organic Chemistry. 43: 2735-2737. DOI: 10.1021/JO00407A053 |
0.101 |
|
| 1989 |
Kozikowski AP, Mugrage BB. Synthesis of optically active thiadecalins and thiahydrindans by a proline-catalyzed intramolecular Michael reaction The Journal of Organic Chemistry. 54: 2274-2275. DOI: 10.1021/JO00271A007 |
0.1 |
|
| 2002 |
Riedel G, Harrington NR, Kozikowski AP, Sandager-Nielsen K, Macphail EM. Variation of CS salience reveals group II mGluR-dependent and -independent forms of conditioning in the rat. Neuropharmacology. 43: 205-14. PMID 12213274 DOI: 10.1016/S0028-3908(02)00096-5 |
0.1 |
|
| 1982 |
Kozikowski AP, Nieduzak TR, Scripko J. Hydroxymercuration-reductive coupling route to .delta.-lactones. Synthesis of malyngolide, an antibiotic from a marine blue-green alga Organometallics. 1: 675-676. DOI: 10.1021/OM00064A018 |
0.099 |
|
| 1979 |
Kozikowski AP, Ames A, Wetter H. Chemistry of the main group metals: A stereoselective synthesis of allyl vinyl thioethers for the thio-claisen reaction Journal of Organometallic Chemistry. 164. DOI: 10.1016/S0022-328X(00)81705-2 |
0.099 |
|
| 1983 |
Kozikowski AP, Sorgi KL, Wang BC, Xu Zb. An improved method for the synthesis of anomerically allylated C-glycopyranosides and C-glycofuranosides Tetrahedron Letters. 24: 1563-1566. DOI: 10.1016/S0040-4039(00)81710-4 |
0.098 |
|
| 1986 |
Kozikowski AP, Cheng X, Li C, Scripko JG. A New Indole Synthesis Promoted by Metal Triflates Israel Journal of Chemistry. 27: 61-65. DOI: 10.1002/IJCH.198600011 |
0.097 |
|
| 1978 |
Kozikowski AP, Schmiesing R. A General Route to Homophthalic Acid Derivatives - Valuable Precursors to Isoquinolinones, Dihydronaphthols and Isocoumarins Synthetic Communications. 8: 363-369. DOI: 10.1080/00397917808063559 |
0.097 |
|
| 1985 |
Kozikowski AP, Okita M. A biomimetic route to the ergot derailment products, the clavicipitic acids - detection of a reactive intermediate by 31p nmr - some chemical underpinnings for a proposed intermediate in ergot alkaloid biosynthesis Tetrahedron Letters. 26: 4043-4046. DOI: 10.1016/S0040-4039(00)89288-6 |
0.095 |
|
| 1998 |
Qiao L, Kozikowski AP. Synthesis of cyclic sphingosine 1,3-phosphate (cSPP) through a photolytic reaction Tetrahedron Letters. 39: 8959-8962. DOI: 10.1016/S0040-4039(98)02071-1 |
0.095 |
|
| 1984 |
Kozikowski AP, Yon-Yih C, B.C W, Xu Z. The intramolecular nitrile oxide cycloaddition (INOC) route to the ergot alkaloids: Use of the isoxazoline to γ-amino alcohol conversion in the total synthesis of (+)-paliclavine Tetrahedron. 40: 2345-2358. DOI: 10.1016/0040-4020(84)80018-6 |
0.095 |
|
| 1983 |
KOZIKOWSKI AP, SCRIPKO J. ChemInform Abstract: EFFICIENT COUPLING REACTIONS OF β-AMINO AND β-ACETAMIDO RADICALS WITH ELECTRON DEFICIENT ALKENES. AZA-CARBOFUNCTIONALIZATION OF OLEFINS. A PROMISING NEW TOOL FOR ALKALOID SYNTHESIS Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198339217 |
0.095 |
|
| 2010 |
KOZIKOWSKI AP, TUECKMANTEL W. ChemInform Abstract: The Synthesis of 2,3,3a,4,5,7a-Hexahydro-1H-inden-1-ols by Intramolecular Diels-Alder Reactions of 1,3,8-Nonatrien-5-ols. Dependence of Product Stereochemistry on the Substitution Pattern. Cheminform. 22: no-no. DOI: 10.1002/CHIN.199140061 |
0.094 |
|
| 1988 |
KOZIKOWSKI AP, LI C. ChemInform Abstract: The Isoxazoline Route to the Hypocholesterolemic Agent Compactin (I): Use of the Isoxazoline as a 1,3-Diene Equivalent. Cheminform. 19. DOI: 10.1002/CHIN.198802355 |
0.091 |
|
| 1984 |
KOZIKOWSKI AP, SCRIPKO JG. ChemInform Abstract: NOC APPROACH TO SPIROKETALS. A TOTAL SYNTHESIS OF (.+-.)-TALAROMYCIN B Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198417372 |
0.09 |
|
| 1984 |
Kozikowski AP, Stein PD. Intramolecular nitrile oxide cycloaddition route to carbocyclics: a formal total synthesis of PGF2.alpha. The Journal of Organic Chemistry. 49: 2301-2309. DOI: 10.1021/JO00187A001 |
0.09 |
|
| 2003 |
Faden AI, Fox GB, Di X, Knoblach SM, Cernak I, Mullins P, Nikolaeva M, Kozikowski AP. Neuroprotective and nootropic actions of a novel cyclized dipeptide after controlled cortical impact injury in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 23: 355-63. PMID 12621310 DOI: 10.1097/01.Wcb.0000046144.31247.33 |
0.089 |
|
| 1980 |
Kozikowski AP, Ames A. Oxazoles in organic chemistry. 2. Application to the synthesis of benzylisoquinoline alkaloids The Journal of Organic Chemistry. 45: 2548-2550. DOI: 10.1021/JO01300A070 |
0.089 |
|
| 1982 |
KOZIKOWSKI AP, CHEN YY. ChemInform Abstract: DIASTEREOFACE SELECTION IN THE INOC REACTION Chemischer Informationsdienst. 13. DOI: 10.1002/chin.198243232 |
0.088 |
|
| 1987 |
Kozikowski AP, Li CS. The isoxazoline route to the hypocholesterolemic agent compactin: use of the isoxazoline as a 1,3-diene equivalent The Journal of Organic Chemistry. 52: 3541-3552. DOI: 10.1021/JO00392A009 |
0.086 |
|
| 1984 |
Kozikowski AP, Scripko JG. NOC approach to spiroketals. A total synthesis of (.+-.)-talaromycin B Journal of the American Chemical Society. 106: 353-355. DOI: 10.1021/JA00314A018 |
0.086 |
|
| 1982 |
Kozikowski AP, Huie EM. Preparation and reactions of 1-(phenylthio)-2-(trimethylsilyloxy)-1,3-butadienes. A one-pot synthesis of sulfur-substituted 7-hydroxybicyclo[2.2.1]heptanones - coupling of the Diels-Alder reaction with the aldol process Journal of the American Chemical Society. 104: 2923-2925. DOI: 10.1021/JA00374A038 |
0.086 |
|
| 1983 |
Kozikowski AP, Scripko J. Efficient Coupling reactions of β-Amino and β-Acetamido Radicals with Electron Deficient Alkenes - Aza-Carbofunctionalization of Olefins - A Promising New Tool for Alkaloid Synthesis Tetrahedron Letters. 24: 2051-2054. DOI: 10.1016/S0040-4039(00)81841-9 |
0.086 |
|
| 2012 |
Yu LF, Zhang HK, Gunosewoyo H, Kozikowski AP. From α4β2 nicotinic ligands to the discovery of σ1 receptor ligands: Pharmacophore analysis and rational design Acs Medicinal Chemistry Letters. 3: 1054-1058. DOI: 10.1021/ml3002715 |
0.085 |
|
| 1985 |
Kozikowski AP, Stein PD. Lewis acid assisted condensations between a 5-methoxyisoxazolidine and silicon-based nucleophiles: .gamma.-amino alcohol building block in the synthesis of agroclavine I Journal of the American Chemical Society. 107: 2569-2571. DOI: 10.1021/JA00294A072 |
0.084 |
|
| 2010 |
Tueckmantel W, Kozikowski AP, Romanczyk Jr. LJ. ChemInform Abstract: Studies in Polyphenol Chemistry and Bioactivity. Part 1. Preparation of Building Blocks from (+)-Catechin. Procyanidin Formation. Synthesis of the Cancer Cell Growth Inhibitor, 3-O-Galloyl-(2R,3R)-epicatechin-4β,8- [3-O-galloyl-(2R,3R Cheminform. 31: no-no. DOI: 10.1002/CHIN.200013216 |
0.083 |
|
| 1982 |
Kozikowski AP, Chen YY. Diastereoface selection in the inoc reaction Tetrahedron Letters. 23: 2081-2084. DOI: 10.1016/S0040-4039(00)87266-4 |
0.082 |
|
| 2011 |
Malkova L, Kozikowski AP, Gale K. The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. Neuropharmacology. 60: 1262-8. PMID 21185313 DOI: 10.1016/j.neuropharm.2010.12.018 |
0.081 |
|
| 2002 |
Wei ZL, Sakamuri S, Petukhov PA, George C, Lewin NE, Blumberg PM, Kozikowski AP. Synthesis and modeling study of (2S,5R,6R)- and (2S,5R,6S)-6-Hydroxy-8-(1-decynyl)-benzolactam-V8 as protein kinase C modulators Organic Letters. 4: 2169-2172. PMID 12074659 DOI: 10.1021/Ol026013U |
0.08 |
|
| 1986 |
KOZIKOWSKI AP, AMES A. ChemInform Abstract: Dimethylaluminum Methaneselenolate: A Useful Reagent for the Preparation of Selenoesters. Chemischer Informationsdienst. 17. DOI: 10.1002/CHIN.198610310 |
0.08 |
|
| 1988 |
Kozikowski AP, Wu JP, Shibuya M, Floss HG. Probing ergot alkaloid biosynthesis: identification of advanced intermediates along the biosynthetic pathway Journal of the American Chemical Society. 110: 1970-1971. DOI: 10.1021/JA00214A054 |
0.079 |
|
| 1995 |
Kozikowski AP, Fauq AH, Wilcox RA, Nahorski SR. Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP4 and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP4 - potent 1d-1,4,5-InsP3-like calcium mobilizing analogues Bioorganic and Medicinal Chemistry Letters. 5: 1295-1300. DOI: 10.1016/0960-894X(95)00210-K |
0.078 |
|
| 2008 |
Kozikowski AP, Reitz AB. Filling the pipeline for neglected diseases: creation of a medicinal chemistry-centric international drug discovery institute [iDDi] Drug Discovery Today. 13: 97-98. PMID 18275906 DOI: 10.1016/j.drudis.2007.12.003 |
0.076 |
|
| 1999 |
Zhao L, Kozikowski AP. Synthesis of the 2β,3β-, 2α,3β-, 2β,3α- and 2α,3α-isomers of 6β-hydroxy-3-(p-tolyl)tropane-2-carboxylic acid methyl ester Tetrahedron Letters. 40: 4961-4964. DOI: 10.1016/S0040-4039(99)00869-2 |
0.076 |
|
| 1991 |
Pang YP, Kozikowski AP. Synthesis of methoxy and hydroxy analogs of 1,2,3,4,4a,9a-hexahydro-4a-fluorenamine: rigid phencyclidine analogs as probes of phencyclidine binding site topography The Journal of Organic Chemistry. 56: 4499-4508. DOI: 10.1021/JO00014A033 |
0.071 |
|
| 1984 |
Kozikowski AP, Hiraga K, Springer JP, Wang BC, Xu ZB. The [(4 + 2) + (3 + 2)] route to multiply fused ring systems: a new notion in polycycle construction Journal of the American Chemical Society. 106: 1845-1847. DOI: 10.1021/JA00318A054 |
0.07 |
|
| 1994 |
Dood DS, Kozikowski AP, Cusack B, Richelson E. Synthesis of partially non-peptidic neurotensin mimetics Bioorganic and Medicinal Chemistry Letters. 4: 1241-1246. DOI: 10.1016/S0960-894X(01)80338-3 |
0.068 |
|
| 1991 |
Yamada F, Kozikowski AP, Reddy ER, Pang YP, Miller JH, McKinney M. A route to optically pure (-)-huperzine A; molecular modeling and in vitro pharmacology Journal of the American Chemical Society. 113: 4695-4696. DOI: 10.1021/JA00012A056 |
0.066 |
|
| 1992 |
Kozikowski AP, Tückmantel W, Powis G. Synthese und biologische Aktivität vonD-3-Desoxy-3-fluorphosphatidylinosit, ein neuer Weg zu nicht auf DNA zielenden Cytostatica Angewandte Chemie. 104: 1408-1410. DOI: 10.1002/ANGE.19921041032 |
0.065 |
|
| 1982 |
Kozikowski AP, Adamczyk M. Methods for the conversion of isoxazolines to β-hydroxy ketones Tetrahedron Letters. 23: 3123-3126. DOI: 10.1016/S0040-4039(00)88575-5 |
0.064 |
|
| 1987 |
Kozikowski AP, Wu JP. Protection of alcohols as their (p-methoxybenzyloxy)methyl ethers Tetrahedron Letters. 28: 5125-5128. DOI: 10.1016/S0040-4039(00)95608-9 |
0.063 |
|
| 1988 |
Kozikowski AP, Mugrage BB. The intramolecular nitrile oxide cycloaddition approach to the mitomycins Journal of the Chemical Society, Chemical Communications. 198-200. DOI: 10.1039/C39880000198 |
0.062 |
|
| 1984 |
Kozikowski AP. The isoxazoline route to the molecules of nature Accounts of Chemical Research. 17: 410-416. DOI: 10.1021/AR00108A001 |
0.061 |
|
| 1988 |
KOZIKOWSKI AP, WU J. ChemInform Abstract: Protection of Alcohols as Their (p-Methoxybenzyloxy)methyl Ethers. Cheminform. 19. DOI: 10.1002/CHIN.198813155 |
0.057 |
|
| 2000 |
Chiang TR, Fanget L, Gregory R, Tang Y, Ardiet DL, Gao L, Meschter C, Kozikowski AP, Buelow R, Vuist WM. Anti-Gal antibodies in humans and 1, 3alpha-galactosyltransferase knock-out mice. Transplantation. 69: 2593-600. PMID 10910282 DOI: 10.1097/00007890-200006270-00020 |
0.054 |
|
| 2013 |
König A, Taoda Y, Kim J, Zhang J, Ellenrieder V, Kozikowski A, Billadeau D. Inhibition von G9a als epigenetische Wachstumskontrolle im Pankreaskarzinom Zeitschrift FüR Gastroenterologie. 51. DOI: 10.1055/S-0033-1352854 |
0.052 |
|
| 1988 |
Kozikowski AP, Lee J. A useful method for converting 2° alcohols to their chlorides with retention of configuration Tetrahedron Letters. 29: 3053-3056. DOI: 10.1016/0040-4039(88)85083-4 |
0.051 |
|
| 1980 |
Kozikowski AP, Ames A. Copper(I) promoted acylation reactions. A transition metal mediated version of the Friedel-Crafts reaction Journal of the American Chemical Society. 102: 860-862. DOI: 10.1021/JA00522A079 |
0.047 |
|
| 1987 |
KOZIKOWSKI AP, JUNG SH. ChemInform Abstract: Phosphoniosilylation: An Efficient and Practical Method for the β-Functionalization of Enones. Cheminform. 18. DOI: 10.1002/CHIN.198708161 |
0.046 |
|
| 2000 |
Qiao L, Hu Y, Nan F, Powis G, Kozikowski AP. A versatile approach to PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 from L-(-)-Quebrachitol Organic Letters. 2: 115-117. PMID 10814260 DOI: 10.1021/OL991188Y |
0.046 |
|
| 1990 |
Kozikowski AP, Lee J. A synthetic approach to the cis-fused marine pyranopyrans, (3E)- and (3Z)-dactomelyne. X-ray structure of a rare organomercurial The Journal of Organic Chemistry. 55: 863-870. DOI: 10.1021/JO00290A014 |
0.046 |
|
| 1986 |
Kozikowski AP, Jung SH. Phosphoniosilylation. An efficient and practical method for the .beta.-functionalization of enones The Journal of Organic Chemistry. 51: 3400-3402. DOI: 10.1021/JO00367A040 |
0.038 |
|
| 1978 |
Kozikowski AP, Schmiesing R. Reactivity of 4,6-dioxy-2-pyrones in the Diels-Alder process Tetrahedron Letters. 19: 4241-4244. DOI: 10.1016/S0040-4039(01)95191-3 |
0.036 |
|
| 1994 |
Dodd DS, Kozikowski AP. Conversion of Alcohols to Protected Guanidines Using the Mitsunobu Protocol Tetrahedron Letters. 35: 977-980. DOI: 10.1016/S0040-4039(00)79943-6 |
0.031 |
|
| 2010 |
Qiao L, Hu Y, Nan F, Powis G, Kozikowski AP. ChemInform Abstract: A Versatile Approach to Pl(3,4)P2, Pl(4,5)P2, and Pl(3,4,5)P3 from L-(-)-Quebrachitol. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200015184 |
0.028 |
|
| 1983 |
Kozikowski AP, Adamcz M. Methods for the stereoselective cis-cyanohydroxylation and -carboxyhydroxylation of olefins The Journal of Organic Chemistry. 48: 366-372. DOI: 10.1021/JO00151A017 |
0.024 |
|
| 2011 |
Kozikowski A, Botta M. Location, Location, Location Chemmedchem. 6: 211-213. PMID 21275042 DOI: 10.1002/cmdc.200000528 |
0.01 |
|
| 2004 |
Pellecchia M, Kozikowski AP. Preface Current Pharmaceutical Design. 10: xxx. |
0.01 |
|
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