| Year |
Citation |
Score |
| 2024 |
Ducommun S, Jannig PR, Cervenka I, Murgia M, Mittenbühler MJ, Chernogubova E, Dias JM, Jude B, Correia JC, Van Vranken JG, Ocana-Santero G, Porsmyr-Palmertz M, McCann Haworth S, Martínez-Redondo V, Liu Z, ... ... Spiegelman BM, et al. Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition. Molecular Metabolism. 101912. PMID 38458566 DOI: 10.1016/j.molmet.2024.101912 |
0.736 |
|
| 2023 |
Dumesic PA, Wilensky SE, Bose S, Van Vranken JG, Gygi SP, Spiegelman BM. RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1α. Biorxiv : the Preprint Server For Biology. PMID 36712038 DOI: 10.1101/2023.01.06.522985 |
0.369 |
|
| 2023 |
Mittenbühler MJ, Jedrychowski MP, Van Vranken JG, Sprenger HG, Wilensky S, Dumesic PA, Sun Y, Tartaglia A, Bogoslavski D, A M, Xiao H, Blackmore KA, Reddy A, Gygi SP, Chouchani ET, ... Spiegelman BM, et al. Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues. Cell Metabolism. PMID 36681077 DOI: 10.1016/j.cmet.2022.12.014 |
0.671 |
|
| 2022 |
Xiao H, Bozi LHM, Sun Y, Riley CL, Philip VM, Chen M, Li J, Zhang T, Mills EL, Emont MP, Sun W, Reddy A, Garrity R, Long J, Becher T, ... ... Spiegelman BM, et al. Architecture of the outbred brown fat proteome defines regulators of metabolic physiology. Cell. PMID 36334589 DOI: 10.1016/j.cell.2022.10.003 |
0.796 |
|
| 2022 |
Jannig PR, Dumesic PA, Spiegelman BM, Ruas JL. SnapShot: Regulation and biology of PGC-1α. Cell. 185: 1444-1444.e1. PMID 35427500 DOI: 10.1016/j.cell.2022.03.027 |
0.753 |
|
| 2022 |
Rahbani JF, Chouchani ET, Spiegelman BM, Kazak L. Measurement of Futile Creatine Cycling Using Respirometry. Methods in Molecular Biology (Clifton, N.J.). 2448: 141-153. PMID 35167096 DOI: 10.1007/978-1-0716-2087-8_10 |
0.767 |
|
| 2021 |
Mills EL, Harmon C, Jedrychowski MP, Xiao H, Gruszczyk AV, Bradshaw GA, Tran N, Garrity R, Laznik-Bogoslavski D, Szpyt J, Prendeville H, Lynch L, Murphy MP, Gygi SP, Spiegelman BM, et al. Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation. Cell Metabolism. PMID 34861155 DOI: 10.1016/j.cmet.2021.11.003 |
0.662 |
|
| 2021 |
Jiang Z, Zhao M, Voilquin L, Jung Y, Aikio MA, Sahai T, Dou FY, Roche AM, Carcamo-Orive I, Knowles JW, Wabitsch M, Appel EA, Maikawa CL, Camporez JP, Shulman GI, ... ... Spiegelman BM, et al. Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis. Cell Metabolism. PMID 34348115 DOI: 10.1016/j.cmet.2021.07.010 |
0.769 |
|
| 2021 |
Sun Y, Rahbani JF, Jedrychowski MP, Riley CL, Vidoni S, Bogoslavski D, Hu B, Dumesic PA, Zeng X, Wang AB, Knudsen NH, Kim CR, Marasciullo A, Millán JL, Chouchani ET, ... ... Spiegelman BM, et al. Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine. Nature. PMID 33981039 DOI: 10.1038/s41586-021-03533-z |
0.82 |
|
| 2021 |
Rahbani JF, Roesler A, Hussain MF, Samborska B, Dykstra CB, Tsai L, Jedrychowski MP, Vergnes L, Reue K, Spiegelman BM, Kazak L. Creatine kinase B controls futile creatine cycling in thermogenic fat. Nature. 590: 480-485. PMID 33597756 DOI: 10.1038/s41586-021-03221-y |
0.691 |
|
| 2021 |
Connell NJ, Doligkeit D, Andriessen C, Kornips-Moonen E, Bruls YMH, Schrauwen-Hinderling VB, van de Weijer T, van Marken-Lichtenbelt WD, Havekes B, Kazak L, Spiegelman BM, Hoeks J, Schrauwen P. No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians. Nature Metabolism. 3: 107-117. PMID 33462512 DOI: 10.1038/s42255-020-00332-0 |
0.624 |
|
| 2020 |
Kazak L, Spiegelman BM. Mechanism of futile creatine cycling in thermogenesis. American Journal of Physiology. Endocrinology and Metabolism. PMID 32954828 DOI: 10.1152/Ajpendo.00444.2020 |
0.59 |
|
| 2020 |
Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, ... ... Spiegelman BM, et al. Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metabolism. PMID 32941798 DOI: 10.1016/J.Cmet.2020.08.016 |
0.783 |
|
| 2020 |
Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, ... ... Spiegelman BM, et al. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell. PMID 32615086 DOI: 10.1016/J.Cell.2020.06.021 |
0.583 |
|
| 2020 |
Kajimura S, Spiegelman BM. Confounding issues in the "humanized" BAT of mice. Nature Metabolism. 2: 303-304. PMID 32405619 DOI: 10.1038/s42255-020-0192-y |
0.517 |
|
| 2020 |
Kim JT, Jedrychowski MP, Wei W, Fernandez D, Fischer CR, Banik SM, Spiegelman BM, Long JZ. A Plasma Protein Network Regulates PM20D1 and N-Acyl Amino Acid Bioactivity. Cell Chemical Biology. PMID 32402239 DOI: 10.1016/J.Chembiol.2020.04.009 |
0.566 |
|
| 2020 |
Jedrychowski MP, Lu GZ, Szpyt J, Mariotti M, Garrity R, Paulo JA, Schweppe DK, Laznik-Bogoslavski D, Kazak L, Murphy MP, Gladyshev VN, Gygi SP, Chouchani ET, Spiegelman BM. Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity. Proceedings of the National Academy of Sciences of the United States of America. PMID 32358195 DOI: 10.1073/Pnas.2001387117 |
0.781 |
|
| 2020 |
Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace D, Spiegelman BM, Kirichok YV. Molecular Identity and Regulatory Mechanisms of the Mitochondrial Uncoupling Protein of Non-Adipose Tissues Biophysical Journal. 118: 185a. DOI: 10.1016/J.Bpj.2019.11.1127 |
0.801 |
|
| 2019 |
Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y. H transport is an integral function of the mitochondrial ADP/ATP carrier. Nature. 571: 515-520. PMID 31341297 DOI: 10.1038/S41586-019-1400-3 |
0.781 |
|
| 2019 |
Kazak L, Rahbani JF, Samborska B, Lu GZ, Jedrychowski MP, Lajoie M, Zhang S, Ramsay LC, Dou FY, Tenen D, Chouchani ET, Dzeja P, Watson IR, Tsai L, Rosen ED, ... Spiegelman BM, et al. Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity. Nature Metabolism. 1: 360-370. PMID 31161155 DOI: 10.1038/s42255-019-0035-x |
0.794 |
|
| 2019 |
Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, ... ... Spiegelman BM, et al. An Evolutionarily Conserved uORF Regulates PGC1α and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna. Cell Metabolism. PMID 31105043 DOI: 10.1016/J.Cmet.2019.04.013 |
0.757 |
|
| 2019 |
Hu B, Jin C, Zeng X, Jedrychowski M, Zhao C, Banks A, Gigi S, Mathis D, Spiegelman B. Abstract B062: Investigate the role of T lymphocytes in the regulation of energy expenditure and obesity Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B062 |
0.376 |
|
| 2018 |
Chouchani ET, Kazak L, Spiegelman BM. New Advances in Adaptive Thermogenesis: UCP1 and Beyond. Cell Metabolism. PMID 30503034 DOI: 10.1016/J.Cmet.2018.11.002 |
0.78 |
|
| 2018 |
Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, Rosen ED. Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metabolism. PMID 30078553 DOI: 10.1016/J.Cmet.2018.07.004 |
0.762 |
|
| 2018 |
Long JZ, Roche AM, Berdan CA, Louie SM, Roberts AJ, Svensson KJ, Dou FY, Bateman LA, Mina AI, Deng Z, Jedrychowski MP, Lin H, Kamenecka TM, Asara JM, Griffin PR, ... ... Spiegelman BM, et al. Ablation of PM20D1 reveals -acyl amino acid control of metabolism and nociception. Proceedings of the National Academy of Sciences of the United States of America. PMID 29967167 DOI: 10.1073/Pnas.1803389115 |
0.782 |
|
| 2018 |
Lin H, Long JZ, Roche AM, Svensson KJ, Dou F, Chang MR, Strutzenberg T, Ruiz C, Cameron MD, Novick SJ, Berdan CM, Louie S, Nomura DK, Spiegelman BM, Griffin PR, et al. Discovery of Hydrolysis-resistant Isoindoline N-Acyl Amino Acid Analogs that Stimulate Mitochondrial Respiration. Journal of Medicinal Chemistry. PMID 29533650 DOI: 10.1021/Acs.Jmedchem.8B00029 |
0.755 |
|
| 2018 |
Khandekar MJ, Banks AS, Laznik-Bogoslavski D, White JP, Choi JH, Kazak L, Lo JC, Cohen P, Wong KK, Kamenecka TM, Griffin PR, Spiegelman BM. Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 29295932 DOI: 10.1073/Pnas.1717776115 |
0.685 |
|
| 2018 |
Bertholet AM, Fedorenko A, Chouchani ET, Kazak L, Angelin A, Vidoni S, Cho J, Terada N, Spiegelman BM, Wallace DC, Kirichok Y. Molecular Identity and Regulatory Mechanisms of the Mitochondrial Uncoupling Protein of Regular Somatic Tissues Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1859: e50. DOI: 10.1016/J.Bbabio.2018.09.150 |
0.762 |
|
| 2017 |
Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM. Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metabolism. 26: 693. PMID 28978428 DOI: 10.1016/J.Cmet.2017.09.007 |
0.804 |
|
| 2017 |
Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM. Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metabolism. PMID 28844881 DOI: 10.1016/J.Cmet.2017.08.009 |
0.818 |
|
| 2017 |
Chouchani ET, Kazak L, Spiegelman BM. Mitochondrial reactive oxygen species and adipose tissue thermogenesis: bridging physiology and mechanisms. The Journal of Biological Chemistry. PMID 28842500 DOI: 10.1074/Jbc.R117.789628 |
0.774 |
|
| 2017 |
Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szpyt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, Spiegelman BM. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. Proceedings of the National Academy of Sciences of the United States of America. PMID 28630339 DOI: 10.1073/Pnas.1705406114 |
0.801 |
|
| 2017 |
Vishvanath L, Long JZ, Spiegelman BM, Gupta RK. Do Adipocytes Emerge from Mural Progenitors? Cell Stem Cell. 20: 585-586. PMID 28475882 DOI: 10.1016/J.Stem.2017.03.013 |
0.714 |
|
| 2017 |
Bertholet AM, Kazak L, Chouchani ET, Bogaczyńska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metabolism. 25: 811-822.e4. PMID 28380374 DOI: 10.1016/J.Bbabio.2018.09.358 |
0.792 |
|
| 2016 |
Sylow L, Long J, Lokurkar IA, Zeng X, Richter EA, Spiegelman BM. The cancer drug Dasatinib increases PGC-1α in adipose tissue but has adverse effects on glucose tolerance in obese mice. Endocrinology. en20161398. PMID 27589085 DOI: 10.1210/en.2016-1398 |
0.661 |
|
| 2016 |
Zeng X, Jedrychowski MP, Chen Y, Serag S, Lavery GG, Gygi SP, Spiegelman BM. Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes & Development. PMID 27566776 DOI: 10.1101/Gad.285312.116 |
0.311 |
|
| 2016 |
Cohen P, Spiegelman BM. Cell biology of fat storage. Molecular Biology of the Cell. 27: 2523-7. PMID 27528697 DOI: 10.1091/Mbc.E15-10-0749 |
0.523 |
|
| 2016 |
Long JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MR, Jedrychowski MP, Paulo JA, Gygi SP, Griffin PR, Nomura DK, Spiegelman BM. The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria. Cell. PMID 27374330 DOI: 10.1016/J.Cell.2016.05.071 |
0.766 |
|
| 2016 |
Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM. Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. PMID 27281219 DOI: 10.1038/Nature18279 |
0.734 |
|
| 2016 |
Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM. Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. PMID 27027295 DOI: 10.1038/Nature17399 |
0.791 |
|
| 2016 |
Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM. A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metabolism. PMID 26876562 DOI: 10.1016/J.Cmet.2016.01.008 |
0.828 |
|
| 2015 |
Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, Spiegelman BM. A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat. Cell. 163: 643-55. PMID 26496606 DOI: 10.1016/J.Cell.2015.09.035 |
0.829 |
|
| 2015 |
Kajimura S, Spiegelman BM, Seale P. Brown and Beige Fat: Physiological Roles beyond Heat Generation. Cell Metabolism. 22: 546-59. PMID 26445512 DOI: 10.1016/J.Cmet.2015.09.007 |
0.744 |
|
| 2015 |
Cohen P, Spiegelman BM. Brown and Beige Fat: Molecular Parts of a Thermogenic Machine. Diabetes. 64: 2346-51. PMID 26050670 DOI: 10.2337/Db15-0318 |
0.525 |
|
| 2015 |
Cipolletta D, Cohen P, Spiegelman BM, Benoist C, Mathis D. Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: age, diet, and PPARγ effects. Proceedings of the National Academy of Sciences of the United States of America. 112: 482-7. PMID 25550516 DOI: 10.1073/Pnas.1423486112 |
0.528 |
|
| 2014 |
White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, MartÃnez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM. G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. 111: 15756-61. PMID 25336758 DOI: 10.1073/Pnas.1417898111 |
0.762 |
|
| 2014 |
Kir S, White JP, Kleiner S, Kazak L, Cohen P, Baracos VE, Spiegelman BM. Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature. 513: 100-4. PMID 25043053 DOI: 10.1038/Nature13528 |
0.719 |
|
| 2014 |
Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, et al. IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell. 158: 69-83. PMID 24995979 DOI: 10.1016/J.Cell.2014.04.049 |
0.819 |
|
| 2014 |
Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, ... ... Spiegelman BM, et al. Adipsin is an adipokine that improves β cell function in diabetes. Cell. 158: 41-53. PMID 24995977 DOI: 10.1016/J.Cell.2014.06.005 |
0.435 |
|
| 2014 |
Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi S, Seehra J, Hawley JA, ... Spiegelman BM, et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 157: 1279-91. PMID 24906147 DOI: 10.1016/J.Cell.2014.03.065 |
0.82 |
|
| 2014 |
Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot JJ, Rosen ED, Spiegelman BM. A smooth muscle-like origin for beige adipocytes. Cell Metabolism. 19: 810-20. PMID 24709624 DOI: 10.1016/J.Cmet.2014.03.025 |
0.802 |
|
| 2014 |
Wu J, Spiegelman BM. Irisin ERKs the fat. Diabetes. 63: 381-3. PMID 24464712 DOI: 10.2337/Db13-1586 |
0.421 |
|
| 2014 |
Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, ... ... Spiegelman BM, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 156: 304-16. PMID 24439384 DOI: 10.1016/J.Cell.2013.12.021 |
0.819 |
|
| 2014 |
Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell. 156: 20-44. PMID 24439368 DOI: 10.1016/J.Cell.2013.12.012 |
0.638 |
|
| 2014 |
Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, ... ... Spiegelman BM, et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metabolism. 19: 96-108. PMID 24411942 DOI: 10.1016/J.Cmet.2013.12.003 |
0.703 |
|
| 2014 |
Lo JC, Ljubicic S, Leibiger B, Chatterjee-Bhowmick D, Kelly ME, Cohen P, Leibiger I, Banks A, Flier J, Bluher M, Danial N, Berggren P, Spiegelman BM. ADIPSIN IS AN ADIPOCYTOKINE DYSREGULATED IN OBESITY/METABOLIC SYNDROME THAT SUSTAINS CARDIOVASCULAR HEALTH Journal of the American College of Cardiology. 63: A2144. DOI: 10.1016/S0735-1097(14)62147-1 |
0.481 |
|
| 2013 |
Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM. Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metabolism. 18: 649-59. PMID 24120943 DOI: 10.1016/J.Cmet.2013.09.008 |
0.607 |
|
| 2013 |
Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP, Spiegelman BM. Fat cells directly sense temperature to activate thermogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 12480-5. PMID 23818608 DOI: 10.1073/Pnas.1310261110 |
0.791 |
|
| 2013 |
Adamovich Y, Shlomai A, Tsvetkov P, Umansky KB, Reuven N, Estall JL, Spiegelman BM, Shaul Y. The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1. Molecular and Cellular Biology. 33: 2603-13. PMID 23648480 DOI: 10.1128/Mcb.01672-12 |
0.69 |
|
| 2013 |
Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM, Puigserver P. PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell. 23: 287-301. PMID 23416000 DOI: 10.1016/J.Ccr.2012.11.020 |
0.59 |
|
| 2013 |
Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes & Development. 27: 234-50. PMID 23388824 DOI: 10.1101/Gad.211649.112 |
0.568 |
|
| 2012 |
Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, ... ... Spiegelman BM, et al. A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell. 151: 1319-31. PMID 23217713 DOI: 10.1016/J.Cell.2012.10.050 |
0.802 |
|
| 2012 |
Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, ... ... Spiegelman BM, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 151: 96-110. PMID 23021218 DOI: 10.1016/J.Cell.2012.08.034 |
0.831 |
|
| 2012 |
Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, ... ... Spiegelman BM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 150: 366-76. PMID 22796012 DOI: 10.1016/J.Cell.2012.05.016 |
0.551 |
|
| 2012 |
Kleiner S, Mepani RJ, Laznik D, Ye L, Jurczak MJ, Jornayvaz FR, Estall JL, Chatterjee Bhowmick D, Shulman GI, Spiegelman BM. Development of insulin resistance in mice lacking PGC-1α in adipose tissues. Proceedings of the National Academy of Sciences of the United States of America. 109: 9635-40. PMID 22645355 DOI: 10.1073/Pnas.1207287109 |
0.745 |
|
| 2012 |
Da Cruz S, Parone PA, Lopes VS, Lillo C, McAlonis-Downes M, Lee SK, Vetto AP, Petrosyan S, Marsala M, Murphy AN, Williams DS, Spiegelman BM, Cleveland DW. Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metabolism. 15: 778-86. PMID 22560226 DOI: 10.1016/J.Cmet.2012.03.019 |
0.455 |
|
| 2012 |
Koncarevic A, Kajimura S, Cornwall-Brady M, Andreucci A, Pullen A, Sako D, Kumar R, Grinberg AV, Liharska K, Ucran JA, Howard E, Spiegelman BM, Seehra J, Lachey J. A novel therapeutic approach to treating obesity through modulation of TGFβ signaling. Endocrinology. 153: 3133-46. PMID 22549226 DOI: 10.1210/En.2012-1016 |
0.656 |
|
| 2012 |
Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metabolism. 15: 395-404. PMID 22405074 DOI: 10.1016/J.Cmet.2012.01.019 |
0.634 |
|
| 2012 |
Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ, Cohen P, Frontini A, Bhowmick DC, Ye L, Cinti S, Spiegelman BM. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metabolism. 15: 230-9. PMID 22326224 DOI: 10.1016/J.Cmet.2012.01.010 |
0.748 |
|
| 2012 |
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes & Development. 26: 271-81. PMID 22302939 DOI: 10.1101/Gad.177857.111 |
0.396 |
|
| 2012 |
Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, ... ... Spiegelman BM, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 481: 463-8. PMID 22237023 DOI: 10.1038/Nature10777 |
0.798 |
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| 2012 |
Spiegelman BM, Korsmeyer SJ. Irisin and the therapeutic benefits of exercise Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-O23 |
0.322 |
|
| 2012 |
Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, ... ... Spiegelman BM, et al. Boström et al. reply Nature. 488: E10-E11. DOI: 10.1038/Nature11365 |
0.708 |
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| 2011 |
Gupta RK, Rosen ED, Spiegelman BM. Identifying novel transcriptional components controlling energy metabolism. Cell Metabolism. 14: 739-45. PMID 22152302 DOI: 10.1016/J.Cmet.2011.11.007 |
0.75 |
|
| 2011 |
Khandekar MJ, Cohen P, Spiegelman BM. Molecular mechanisms of cancer development in obesity. Nature Reviews. Cancer. 11: 886-95. PMID 22113164 DOI: 10.1038/Nrc3174 |
0.456 |
|
| 2011 |
Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, Kharitonenkov A, Spiegelman BM, Maratos-Flier E. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology. 152: 2996-3004. PMID 21712364 DOI: 10.1210/En.2011-0281 |
0.68 |
|
| 2011 |
Lustig Y, Ruas JL, Estall JL, Lo JC, Devarakonda S, Laznik D, Choi JH, Ono H, Olsen JV, Spiegelman BM. Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. Genes & Development. 25: 1232-44. PMID 21646374 DOI: 10.1101/Gad.2054711 |
0.816 |
|
| 2011 |
Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metabolism. 13: 160-9. PMID 21284983 DOI: 10.1016/J.Cmet.2011.01.003 |
0.793 |
|
| 2011 |
Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. The Journal of Clinical Investigation. 121: 96-105. PMID 21123942 DOI: 10.1172/Jci44271 |
0.827 |
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| 2010 |
Boström P, Mann N, Wu J, Quintero PA, Plovie ER, Panáková D, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM. C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell. 143: 1072-83. PMID 21183071 DOI: 10.1016/J.Cell.2010.11.036 |
0.62 |
|
| 2010 |
Rasbach KA, Gupta RK, Ruas JL, Wu J, Naseri E, Estall JL, Spiegelman BM. PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proceedings of the National Academy of Sciences of the United States of America. 107: 21866-71. PMID 21106753 DOI: 10.1073/Pnas.1016089107 |
0.805 |
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| 2010 |
Chakkalakal JV, Nishimune H, Ruas JL, Spiegelman BM, Sanes JR. Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons. Development (Cambridge, England). 137: 3489-99. PMID 20843861 DOI: 10.1242/dev.053348 |
0.719 |
|
| 2010 |
Choi JH, Banks AS, Estall JL, Kajimura S, Boström P, Laznik D, Ruas JL, Chalmers MJ, Kamenecka TM, Blüher M, Griffin PR, Spiegelman BM. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature. 466: 451-6. PMID 20651683 DOI: 10.1038/Nature09291 |
0.808 |
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| 2010 |
Kajimura S, Seale P, Spiegelman BM. Transcriptional control of brown fat development. Cell Metabolism. 11: 257-62. PMID 20374957 DOI: 10.1016/J.Cmet.2010.03.005 |
0.708 |
|
| 2010 |
Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM. Transcriptional control of preadipocyte determination by Zfp423. Nature. 464: 619-23. PMID 20200519 DOI: 10.1038/Nature08816 |
0.785 |
|
| 2010 |
Handschin C, Summermatter S, LeBrasseur NK, Lin J, Spiegelman BM. For a pragmatic approach to exercise studies. Journal of Applied Physiology (Bethesda, Md. : 1985). 108: 223-3; author reply . PMID 20066760 DOI: 10.1152/Japplphysiol.01233.2009 |
0.493 |
|
| 2009 |
Estall JL, Ruas JL, Choi CS, Laznik D, Badman M, Maratos-Flier E, Shulman GI, Spiegelman BM. PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proceedings of the National Academy of Sciences of the United States of America. 106: 22510-5. PMID 20018698 DOI: 10.1073/Pnas.0912533106 |
0.809 |
|
| 2009 |
Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 460: 1154-8. PMID 19641492 DOI: 10.1038/Nature08262 |
0.745 |
|
| 2009 |
Kleiner S, Nguyen-Tran V, Baré O, Huang X, Spiegelman B, Wu Z. PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function. The Journal of Biological Chemistry. 284: 18624-33. PMID 19435887 DOI: 10.1074/jbc.M109.008797 |
0.329 |
|
| 2009 |
Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM. Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. Diabetes. 58: 1499-508. PMID 19366863 DOI: 10.2337/Db08-1571 |
0.706 |
|
| 2009 |
Seale P, Kajimura S, Spiegelman BM. Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes & Development. 23: 788-97. PMID 19339685 DOI: 10.1101/Gad.1779209 |
0.74 |
|
| 2009 |
Peraldi P, Hotamisligil GS, Buurman WA, White M, Spiegelman BM. O-47: Mechanisms of TNF-α induced insulin resistance Experimental and Clinical Endocrinology & Diabetes. 104: 59-59. DOI: 10.1055/s-0029-1211538 |
0.471 |
|
| 2008 |
Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, ... Spiegelman BM, et al. Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America. 105: 19926-31. PMID 19066218 DOI: 10.1073/Pnas.0810339105 |
0.636 |
|
| 2008 |
Cooper MP, Uldry M, Kajimura S, Arany Z, Spiegelman BM. Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. The Journal of Biological Chemistry. 283: 31960-7. PMID 18728005 DOI: 10.1074/Jbc.M805431200 |
0.665 |
|
| 2008 |
Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 454: 961-7. PMID 18719582 DOI: 10.1038/Nature07182 |
0.762 |
|
| 2008 |
Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PPARgamma. Annual Review of Biochemistry. 77: 289-312. PMID 18518822 DOI: 10.1146/Annurev.Biochem.77.061307.091829 |
0.557 |
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| 2008 |
Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes & Development. 22: 1397-409. PMID 18483224 DOI: 10.1101/Gad.1666108 |
0.819 |
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| 2008 |
Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature. 451: 1008-12. PMID 18288196 DOI: 10.1038/nature06613 |
0.754 |
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| 2008 |
Calvo JA, Daniels TG, Wang X, Paul A, Lin J, Spiegelman BM, Stevenson SC, Rangwala SM. Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. Journal of Applied Physiology (Bethesda, Md. : 1985). 104: 1304-12. PMID 18239076 DOI: 10.1152/Japplphysiol.01231.2007 |
0.593 |
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| 2007 |
Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. The Journal of Clinical Investigation. 117: 3463-74. PMID 17932564 DOI: 10.1172/Jci31785 |
0.315 |
|
| 2007 |
Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. Transcriptional control of brown fat determination by PRDM16. Cell Metabolism. 6: 38-54. PMID 17618855 DOI: 10.1016/J.Cmet.2007.06.001 |
0.754 |
|
| 2007 |
Rohas LM, St-Pierre J, Uldry M, Jäger S, Handschin C, Spiegelman BM. A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proceedings of the National Academy of Sciences of the United States of America. 104: 7933-8. PMID 17470778 DOI: 10.1073/pnas.0702683104 |
0.308 |
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| 2007 |
Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP, Spiegelman BM. PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes & Development. 21: 770-83. PMID 17403779 DOI: 10.1101/Gad.1525107 |
0.598 |
|
| 2007 |
Li P, Carling D, Hotamisligil GS, Bernlohr DA, Attie AD, Kim JB, Spiegelman BM. Discussion Novartis Foundation Symposium. 286: 81-85. |
0.403 |
|
| 2006 |
Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 444: 847-53. PMID 17167472 DOI: 10.1038/Nature05483 |
0.646 |
|
| 2006 |
Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB. Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metabolism. 4: 453-64. PMID 17141629 DOI: 10.1016/J.Cmet.2006.11.003 |
0.619 |
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| 2006 |
St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 127: 397-408. PMID 17055439 DOI: 10.1016/J.Cell.2006.09.024 |
0.59 |
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| 2006 |
Sandri M, Lin J, Handschin C, Yang W, Arany ZP, Lecker SH, Goldberg AL, Spiegelman BM. PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proceedings of the National Academy of Sciences of the United States of America. 103: 16260-5. PMID 17053067 DOI: 10.1073/Pnas.0607795103 |
0.611 |
|
| 2006 |
Cooper MP, Qu L, Rohas LM, Lin J, Yang W, Erdjument-Bromage H, Tempst P, Spiegelman BM. Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes & Development. 20: 2996-3009. PMID 17050673 DOI: 10.1101/Gad.1483906 |
0.619 |
|
| 2006 |
Handschin C, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocrine Reviews. 27: 728-35. PMID 17018837 DOI: 10.1210/er.2006-0037 |
0.344 |
|
| 2006 |
Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC. Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 14379-84. PMID 16980408 DOI: 10.1073/Pnas.0606714103 |
0.433 |
|
| 2006 |
Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metabolism. 3: 333-41. PMID 16679291 DOI: 10.1016/J.Cmet.2006.04.002 |
0.754 |
|
| 2006 |
Rhee J, Ge H, Yang W, Fan M, Handschin C, Cooper M, Lin J, Li C, Spiegelman BM. Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. The Journal of Biological Chemistry. 281: 14683-90. PMID 16574644 DOI: 10.1074/Jbc.M512636200 |
0.608 |
|
| 2006 |
Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation (DOI:10.1016/j.cmet.2006.04.002) Cell Metabolism. 4: 97. DOI: 10.1016/J.Cmet.2006.06.005 |
0.726 |
|
| 2005 |
Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, Moore DD. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metabolism. 2: 227-38. PMID 16213225 DOI: 10.1016/J.Cmet.2005.08.010 |
0.324 |
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| 2005 |
Handschin C, Lin J, Rhee J, Peyer AK, Chin S, Wu PH, Meyer UA, Spiegelman BM. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell. 122: 505-15. PMID 16122419 DOI: 10.1016/J.Cell.2005.06.040 |
0.576 |
|
| 2005 |
Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (New York, N.Y.). 309: 1074-8. PMID 16099986 DOI: 10.1126/Science.1110955 |
0.454 |
|
| 2005 |
Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators Cell Metabolism. 1: 361-370. PMID 16054085 DOI: 10.1016/J.Cmet.2005.05.004 |
0.634 |
|
| 2005 |
Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, ... ... Spiegelman BM, et al. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metabolism. 1: 259-71. PMID 16054070 DOI: 10.1016/J.Cmet.2005.03.002 |
0.613 |
|
| 2005 |
Chen Z, Torrens JI, Anand A, Spiegelman BM, Friedman JM. Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metabolism. 1: 93-106. PMID 16054051 DOI: 10.1016/J.Cmet.2004.12.009 |
0.445 |
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| 2005 |
Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 434: 113-8. PMID 15744310 DOI: 10.1038/Nature03354 |
0.794 |
|
| 2005 |
Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell. 120: 261-73. PMID 15680331 DOI: 10.1016/J.Cell.2004.11.043 |
0.691 |
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| 2005 |
Brown M, Flier J, Friedman J, Goldstein J, Kahn CR, Lifton R, O'Rahilly S, Spiegelman B. Cell Metabolism: Why, and why now? Cell Metabolism. 1: 3. DOI: 10.1016/J.Cmet.2004.12.007 |
0.529 |
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| 2004 |
Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, ... ... Spiegelman BM, et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 119: 121-35. PMID 15454086 DOI: 10.1016/J.Cell.2004.09.013 |
0.648 |
|
| 2004 |
Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences of the United States of America. 101: 6570-5. PMID 15100410 DOI: 10.1073/Pnas.0401401101 |
0.612 |
|
| 2004 |
Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Molecular and Cellular Biology. 24: 3057-67. PMID 15024092 DOI: 10.1128/Mcb.24.7.3057-3067.2004 |
0.62 |
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| 2004 |
Fan M, Rhee J, St-Pierre J, Handschin C, Puigserver P, Lin J, Jäeger S, Erdjument-Bromage H, Tempst P, Spiegelman BM. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes & Development. 18: 278-89. PMID 14744933 DOI: 10.1101/Gad.1152204 |
0.722 |
|
| 2003 |
Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Molecular and Cellular Biology. 23: 7222-9. PMID 14517292 DOI: 10.1128/Mcb.23.20.7222-7229.2003 |
0.603 |
|
| 2003 |
Norris AW, Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC, Hirshman MF, Rosen ED, Goodyear LJ, Gonzalez FJ, Spiegelman BM, Kahn CR. Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. The Journal of Clinical Investigation. 112: 608-18. PMID 12925701 DOI: 10.1172/Jci17305 |
0.637 |
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| 2003 |
Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Developmental Cell. 5: 73-83. PMID 12852853 DOI: 10.1016/S1534-5807(03)00170-9 |
0.602 |
|
| 2003 |
Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, ... ... Spiegelman B, et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genetics. 34: 267-73. PMID 12808457 DOI: 10.1038/Ng1180 |
0.628 |
|
| 2003 |
Lin J, Tarr PT, Yang R, Rhee J, Puigserver P, Newgard CB, Spiegelman BM. PGC-1beta in the regulation of hepatic glucose and energy metabolism. The Journal of Biological Chemistry. 278: 30843-8. PMID 12807885 DOI: 10.1074/Jbc.M303643200 |
0.731 |
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| 2003 |
Handschin C, Rhee J, Lin J, Tarr PT, Spiegelman BM. An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle Proceedings of the National Academy of Sciences of the United States of America. 100: 7111-7116. PMID 12764228 DOI: 10.1073/Pnas.1232352100 |
0.603 |
|
| 2003 |
Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 423: 550-5. PMID 12754525 DOI: 10.1038/Nature01667 |
0.606 |
|
| 2003 |
St-Pierre J, Lin J, Krauss S, Tarr PT, Yang R, Newgard CB, Spiegelman BM. Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. The Journal of Biological Chemistry. 278: 26597-603. PMID 12734177 DOI: 10.1074/Jbc.M301850200 |
0.628 |
|
| 2003 |
Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, Spiegelman BM. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 4012-7. PMID 12651943 DOI: 10.1073/Pnas.0730870100 |
0.589 |
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| 2003 |
Puigserver P, Spiegelman BM. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocrine Reviews. 24: 78-90. PMID 12588810 DOI: 10.1210/Er.2002-0012 |
0.635 |
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| 2003 |
Tritos NA, Mastaitis JW, Kokkotou EG, Puigserver P, Spiegelman BM, Maratos-Flier E. Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain. Brain Research. 961: 255-60. PMID 12531492 DOI: 10.1016/S0006-8993(02)03961-6 |
0.592 |
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| 2002 |
Mueller E, Drori S, Aiyer A, Yie J, Sarraf P, Chen H, Hauser S, Rosen ED, Ge K, Roeder RG, Spiegelman BM. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. The Journal of Biological Chemistry. 277: 41925-30. PMID 12200443 DOI: 10.1074/Jbc.M206950200 |
0.631 |
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| 2002 |
Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature. 418: 797-801. PMID 12181572 DOI: 10.1038/Nature00904 |
0.741 |
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| 2002 |
Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes & Development. 16: 22-6. PMID 11782441 DOI: 10.1101/Gad.948702 |
0.594 |
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| 2002 |
Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. The Journal of Biological Chemistry. 277: 1645-8. PMID 11733490 DOI: 10.1074/Jbc.C100631200 |
0.731 |
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| 2001 |
Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Molecular Cell. 8: 971-82. PMID 11741533 DOI: 10.1016/S1097-2765(01)00390-2 |
0.716 |
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| 2001 |
Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria CT, Cheng A, Wu Z, Gingras AC, Katsume A, Elchebly M, Spiegelman BM, Harper ME, Tremblay ML, Sonenberg N. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nature Medicine. 7: 1128-32. PMID 11590436 DOI: 10.1038/Nm1001-1128 |
0.339 |
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| 2001 |
Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 413: 179-83. PMID 11557984 DOI: 10.1038/35093131 |
0.654 |
|
| 2001 |
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 413: 131-8. PMID 11557972 DOI: 10.1038/35093050 |
0.591 |
|
| 2001 |
Rosen ED, Spiegelman BM. PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth. The Journal of Biological Chemistry. 276: 37731-4. PMID 11459852 DOI: 10.1074/Jbc.R100034200 |
0.606 |
|
| 2001 |
Michael LF, Wu Z, Cheatham RB, Puigserver P, Adelmant G, Lehman JJ, Kelly DP, Spiegelman BM. Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proceedings of the National Academy of Sciences of the United States of America. 98: 3820-5. PMID 11274399 DOI: 10.1073/Pnas.061035098 |
0.596 |
|
| 2001 |
Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW. The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. Nature Medicine. 7: 41-7. PMID 11135614 DOI: 10.1038/83328 |
0.583 |
|
| 2001 |
Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis. Annual Review of Cell and Developmental Biology. 16: 145-71. PMID 11031233 DOI: 10.1146/Annurev.Cellbio.16.1.145 |
0.618 |
|
| 2001 |
Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. Erratum: correction: CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 Nature. 413: 652-652. DOI: 10.1038/35098123 |
0.614 |
|
| 2000 |
Spiegelman BM, Puigserver P, Wu Z. Regulation of adipogenesis and energy balance by PPARgamma and PGC-1. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association For the Study of Obesity. 24: S8-10. PMID 11126248 DOI: 10.1038/Sj.Ijo.0801492 |
0.687 |
|
| 2000 |
Rosen ED, Spiegelman BM. Peroxisome proliferator-activated receptor gamma ligands and atherosclerosis: ending the heartache. The Journal of Clinical Investigation. 106: 629-31. PMID 10974014 DOI: 10.1172/Jci10909 |
0.644 |
|
| 2000 |
Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, Friedman JM, Holmes WE, Spiegelman BM. Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Molecular and Cellular Biology. 20: 5343-9. PMID 10866690 DOI: 10.1128/Mcb.20.14.5343-5349.2000 |
0.718 |
|
| 2000 |
Tcherepanova I, Puigserver P, Norris JD, Spiegelman BM, McDonnell DP. Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. The Journal of Biological Chemistry. 275: 16302-8. PMID 10748020 DOI: 10.1074/Jbc.M001364200 |
0.573 |
|
| 2000 |
Xu Y, Ma M, Ippolito GC, Johnson RS, Szalai AJ, Spiegelman BM, Schroeder HW, Carroll MC, Volanakis JE. Activation of the alternative complement pathway in factor D-deficient mice Immunopharmacology. 49: 80. DOI: 10.1016/S0162-3109(00)80232-5 |
0.453 |
|
| 1999 |
Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM. Activation of PPARgamma coactivator-1 through transcription factor docking. Science (New York, N.Y.). 286: 1368-71. PMID 10558993 DOI: 10.1126/Science.286.5443.1368 |
0.568 |
|
| 1999 |
Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Molecular Cell. 4: 611-7. PMID 10549292 DOI: 10.1016/S1097-2765(00)80211-7 |
0.636 |
|
| 1999 |
Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 98: 115-24. PMID 10412986 DOI: 10.1016/S0092-8674(00)80611-X |
0.606 |
|
| 1999 |
Fajas L, Schoonjans K, Gelman L, Kim JB, Najib J, Martin G, Fruchart JC, Briggs M, Spiegelman BM, Auwerx J. Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Molecular and Cellular Biology. 19: 5495-503. PMID 10409739 DOI: 10.1128/Mcb.19.8.5495 |
0.509 |
|
| 1999 |
Devine JH, Eubank DW, Clouthier DE, Tontonoz P, Spiegelman BM, Hammer RE, Beale EG. Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo. The Journal of Biological Chemistry. 274: 13604-12. PMID 10224131 DOI: 10.1074/Jbc.274.19.13604 |
0.52 |
|
| 1999 |
Foretz M, Pacot C, Dugail I, Lemarchand P, Guichard C, Le Lièpvre X, Berthelier-Lubrano C, Spiegelman B, Kim JB, Ferré P, Foufelle F. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Molecular and Cellular Biology. 19: 3760-8. PMID 10207099 DOI: 10.1128/Mcb.19.5.3760 |
0.539 |
|
| 1999 |
Wu Z, Rosen ED, Brun R, Hauser S, Adelmant G, Troy AE, McKeon C, Darlington GJ, Spiegelman BM. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Molecular Cell. 3: 151-8. PMID 10078198 DOI: 10.1016/S1097-2765(00)80306-8 |
0.626 |
|
| 1999 |
King FJ, Hu E, Harris DF, Sarraf P, Spiegelman BM, Roberts TM. DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines. Molecular and Cellular Biology. 19: 2330-7. PMID 10022919 DOI: 10.1128/Mcb.19.3.2330 |
0.303 |
|
| 1999 |
Rosen ED, Spiegelman BM. Tumor necrosis factor-α as a mediator of the insulin resistance of obesity Current Opinion in Endocrinology & Diabetes. 6: 170-176. DOI: 10.1097/00060793-199904000-00014 |
0.585 |
|
| 1998 |
Mueller E, Sarraf P, Tontonoz P, Evans RM, Martin KJ, Zhang M, Fletcher C, Singer S, Spiegelman BM. Terminal differentiation of human breast cancer through PPAR gamma. Molecular Cell. 1: 465-70. PMID 9660931 DOI: 10.1016/S1097-2765(00)80047-7 |
0.467 |
|
| 1998 |
Serova LI, Saez E, Spiegelman BM, Sabban EL. c-Fos deficiency inhibits induction of mRNA for some, but not all, neurotransmitter biosynthetic enzymes by immobilization stress Journal of Neurochemistry. 70: 1935-1940. PMID 9572277 DOI: 10.1046/J.1471-4159.1998.70051935.X |
0.606 |
|
| 1998 |
Kim JB, Wright HM, Wright M, Spiegelman BM. ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. Proceedings of the National Academy of Sciences of the United States of America. 95: 4333-7. PMID 9539737 DOI: 10.1073/Pnas.95.8.4333 |
0.447 |
|
| 1998 |
Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 92: 829-39. PMID 9529258 DOI: 10.1016/S0092-8674(00)81410-5 |
0.659 |
|
| 1998 |
Kim JB, Sarraf P, Wright M, Yao KM, Mueller E, Solanes G, Lowell BB, Spiegelman BM. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1 Journal of Clinical Investigation. 101: 1-9. PMID 9421459 DOI: 10.1172/Jci1411 |
0.523 |
|
| 1998 |
Peraldi P, Spiegelman BM. Studies of the mechanism of inhibition of insulin signaling by tumor necrosis factor-alpha. The Journal of Endocrinology. 155: 219-20. PMID 9415053 DOI: 10.1677/Joe.0.1550219 |
0.306 |
|
| 1998 |
Sabban EL, Nankova BB, Serova LI, Hiremagalur B, Rusnak M, Saez E, Spiegelman B, Kvetnanský R. Regulation of gene expression of catecholamine biosynthetic enzymes by stress. Advances in Pharmacology (San Diego, Calif.). 42: 564-7. PMID 9327964 DOI: 10.1016/S1054-3589(08)60813-3 |
0.648 |
|
| 1998 |
Peraldi P, Spiegelman B. Molecular and Cellular Biochemistry. 182: 169-175. DOI: 10.1023/A:1006865715292 |
0.342 |
|
| 1997 |
Brun RP, Kim JB, Hu E, Spiegelman BM. Peroxisome proliferator-activated receptor gamma and the control of adipogenesis. Current Opinion in Lipidology. 8: 212-8. PMID 9253537 DOI: 10.1097/00041433-199708000-00004 |
0.48 |
|
| 1997 |
Spiegelman BM, Hu E, Kim JB, Brun R. PPAR gamma and the control of adipogenesis. Biochimie. 79: 111-2. PMID 9209705 DOI: 10.1016/S0300-9084(97)81500-3 |
0.448 |
|
| 1997 |
Ericsson J, Jackson SM, Kim JB, Spiegelman BM, Edwards PA. Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene. The Journal of Biological Chemistry. 272: 7298-305. PMID 9054427 DOI: 10.1074/Jbc.272.11.7298 |
0.483 |
|
| 1997 |
Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM. Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes. 46: 451-5. PMID 9032102 DOI: 10.2337/Diab.46.3.451 |
0.575 |
|
| 1997 |
Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM, Lowell BB. Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter Journal of Biological Chemistry. 272: 5283-5290. PMID 9030601 DOI: 10.1074/Jbc.272.8.5283 |
0.539 |
|
| 1997 |
Tontonoz P, Singer S, Forman BM, Sarraf P, Fletcher JA, Fletcher CD, Brun RP, Mueller E, Altiok S, Oppenheim H, Evans RM, Spiegelman BM. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. Proceedings of the National Academy of Sciences of the United States of America. 94: 237-41. PMID 8990192 DOI: 10.1073/Pnas.94.1.237 |
0.514 |
|
| 1997 |
Hu E, Kim JB, Sarraf P, Spiegelman BM. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma. Science (New York, N.Y.). 274: 2100-3. PMID 8953045 DOI: 10.1126/Science.274.5295.2100 |
0.489 |
|
| 1997 |
Brun RP, Kim JB, Hu E, Altiok S, Spiegelman BM. Adipocyte differentiation: a transcriptional regulatory cascade. Current Opinion in Cell Biology. 8: 826-32. PMID 8939673 DOI: 10.1016/S0955-0674(96)80084-6 |
0.5 |
|
| 1996 |
Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science (New York, N.Y.). 274: 1377-9. PMID 8910278 DOI: 10.1126/Science.274.5291.1377 |
0.693 |
|
| 1996 |
Honrado GI, Johnson RS, Golombek DA, Spiegelman BM, Papaioannou VE, Ralph MR. The circadian system of c-fos deficient mice. Journal of Comparative Physiology. a, Sensory, Neural, and Behavioral Physiology. 178: 563-70. PMID 8847666 DOI: 10.1007/Bf00190186 |
0.446 |
|
| 1996 |
Johnson R, Spiegelman B, Hanahan D, Wisdom R. Cellular transformation and malignancy induced by ras require c-jun Molecular and Cellular Biology. 16: 4504-4511. PMID 8754851 DOI: 10.1128/Mcb.16.8.4504 |
0.635 |
|
| 1996 |
Tontonoz P, Hu E, Spiegelman BM. Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma. Current Opinion in Genetics & Development. 5: 571-6. PMID 8664544 DOI: 10.1016/0959-437X(95)80025-5 |
0.573 |
|
| 1996 |
Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. The Journal of Biological Chemistry. 271: 13018-22. PMID 8662983 DOI: 10.1074/Jbc.271.22.13018 |
0.522 |
|
| 1996 |
Vidal-Puig A, Jimenez-Liñan M, Lowell BB, Hamann A, Hu E, Spiegelman B, Flier JS, Moller DE. Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. The Journal of Clinical Investigation. 97: 2553-61. PMID 8647948 DOI: 10.1172/Jci118703 |
0.435 |
|
| 1996 |
Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. The Journal of Biological Chemistry. 271: 10697-703. PMID 8631877 DOI: 10.1074/Jbc.271.18.10697 |
0.322 |
|
| 1996 |
Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM, Spiegelman BM. Differential activation of adipogenesis by multiple PPAR isoforms. Genes & Development. 10: 974-84. PMID 8608944 DOI: 10.1101/Gad.10.8.974 |
0.554 |
|
| 1996 |
Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science (New York, N.Y.). 271: 665-8. PMID 8571133 DOI: 10.1126/Science.271.5249.665 |
0.547 |
|
| 1996 |
Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell. 83: 803-12. PMID 8521497 DOI: 10.1016/0092-8674(95)90193-0 |
0.542 |
|
| 1995 |
Kopecky J, Clarke G, Enerbäck S, Spiegelman B, Kozak LP. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. The Journal of Clinical Investigation. 96: 2914-23. PMID 8675663 DOI: 10.1172/Jci118363 |
0.443 |
|
| 1995 |
Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 79: 1147-56. PMID 8001151 DOI: 10.1016/0092-8674(94)90006-X |
0.562 |
|
| 1995 |
Tontonoz P, Graves RA, Budavari AI, Erdjument-Bromage H, Lui M, Hu E, Tempst P, Spiegelman BM. Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. Nucleic Acids Research. 22: 5628-34. PMID 7838715 DOI: 10.1093/Nar/22.25.5628 |
0.552 |
|
| 1995 |
Tontonoz P, Hu E, Devine J, Beale EG, Spiegelman BM. PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Molecular and Cellular Biology. 15: 351-7. PMID 7799943 DOI: 10.1128/Mcb.15.1.351 |
0.586 |
|
| 1995 |
Kim JB, Spotts GD, Halvorsen YD, Shih HM, Ellenberger T, Towle HC, Spiegelman BM. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain Molecular and Cellular Biology. 15: 2582-2588. PMID 7739539 DOI: 10.1128/Mcb.15.5.2582 |
0.448 |
|
| 1995 |
Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. The Journal of Clinical Investigation. 95: 2409-15. PMID 7738205 DOI: 10.1172/Jci117936 |
0.581 |
|
| 1995 |
Hu E, Tontonoz P, Spiegelman BM. Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha. Proceedings of the National Academy of Sciences of the United States of America. 92: 9856-60. PMID 7568232 DOI: 10.1073/Pnas.92.21.9856 |
0.567 |
|
| 1995 |
Saez E, Rutberg SE, Mueller E, Oppenheim H, Smoluk J, Yuspa SH, Spiegelman BM. c-fos is required for malignant progression of skin tumors. Cell. 82: 721-32. PMID 7545543 DOI: 10.1016/0092-8674(95)90469-7 |
0.595 |
|
| 1994 |
Hofmann C, Lorenz K, Braithwaite SS, Colca JR, Palazuk BJ, Hotamisligil GS, Spiegelman BM. Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. Endocrinology. 134: 264-70. PMID 8275942 DOI: 10.1210/endo.134.1.8275942 |
0.579 |
|
| 1994 |
Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 91: 4854-8. PMID 8197147 DOI: 10.1073/Pnas.91.11.4854 |
0.515 |
|
| 1994 |
Jain J, Nalefski EA, McCaffrey PG, Johnson RS, Spiegelman BM, Papaioannou V, Rao A. Normal peripheral T-cell function in c-Fos-deficient mice. Molecular and Cellular Biology. 14: 1566-74. PMID 8114694 DOI: 10.1128/Mcb.14.3.1566 |
0.47 |
|
| 1994 |
Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes & Development. 8: 1224-34. PMID 7926726 DOI: 10.1101/Gad.8.10.1224 |
0.571 |
|
| 1994 |
Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes. 43: 1271-8. PMID 7926300 DOI: 10.2337/Diab.43.11.1271 |
0.552 |
|
| 1994 |
Paylor R, Johnson RS, Papaioannou V, Spiegelman BM, Wehner JM. Behavioral assessment of c-fos mutant mice Brain Research. 651: 275-282. PMID 7922576 DOI: 10.1016/0006-8993(94)90707-2 |
0.407 |
|
| 1994 |
Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. The Journal of Clinical Investigation. 94: 1543-9. PMID 7523453 DOI: 10.1172/JCI117495 |
0.56 |
|
| 1994 |
Hu E, Mueller E, Oliviero S, Papaioannou V, Johnson R, Spiegelman B. Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes. The Embo Journal. 13: 3094-3103. DOI: 10.1002/J.1460-2075.1994.Tb06608.X |
0.482 |
|
| 1993 |
Spiegelman BM, Hotamisligil GS. Through thick and thin: wasting, obesity, and TNF alpha. Cell. 73: 625-7. PMID 8500160 DOI: 10.1016/0092-8674(93)90243-J |
0.514 |
|
| 1993 |
Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. The Journal of Biological Chemistry. 268: 6823-6. PMID 8463205 |
0.545 |
|
| 1993 |
Tontonoz P, Kim JB, Graves RA, Spiegelman BM. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Molecular and Cellular Biology. 13: 4753-9. PMID 8336713 DOI: 10.1128/Mcb.13.8.4753 |
0.643 |
|
| 1993 |
Ross SR, Graves RA, Spiegelman BM. Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity. Genes & Development. 7: 1318-24. PMID 8330737 DOI: 10.1101/Gad.7.7B.1318 |
0.305 |
|
| 1993 |
Johnson RS, van Lingen B, Papaioannou VE, Spiegelman BM. A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes & Development. 7: 1309-17. PMID 8330736 DOI: 10.1101/Gad.7.7B.1309 |
0.463 |
|
| 1993 |
Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (New York, N.Y.). 259: 87-91. PMID 7678183 DOI: 10.1126/Science.7678183 |
0.56 |
|
| 1992 |
Graves RA, Tontonoz P, Platt KA, Ross SR, Spiegelman BM. Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression. Journal of Cellular Biochemistry. 49: 219-24. PMID 1644859 DOI: 10.1002/Jcb.240490303 |
0.552 |
|
| 1992 |
Graves RA, Tontonoz P, Spiegelman BM. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Molecular and Cellular Biology. 12: 1202-8. PMID 1545801 DOI: 10.1128/Mcb.12.3.1202 |
0.54 |
|
| 1992 |
Johnson RS, Spiegelman BM, Papaioannou V. Pleiotropic effects of a null mutation in the c-fos proto-oncogene Cell. 71: 577-586. PMID 1423615 DOI: 10.1016/0092-8674(92)90592-Z |
0.454 |
|
| 1992 |
Field SJ, Johnson RS, Mortensen RM, Papaioannou VE, Spiegelman BM, Greenberg ME. Growth and differentiation of embryonic stem cells that lack an intact c-fos gene. Proceedings of the National Academy of Sciences of the United States of America. 89: 9306-10. PMID 1329091 DOI: 10.1073/Pnas.89.19.9306 |
0.469 |
|
| 1991 |
Graves RA, Tontonoz P, Ross SR, Spiegelman BM. Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor. Genes & Development. 5: 428-37. PMID 2001842 DOI: 10.1101/Gad.5.3.428 |
0.54 |
|
| 1990 |
Johnson PR, Spiegelman B, Rosen B, Turkenkopf I, Ree H, Greenwood MR. Reduced adipsin mRNA and circulating adipsin protein are modulated by adrenal steroids in obese Zucker rats. The American Journal of Physiology. 259: R184-8. PMID 2197880 DOI: 10.1152/Ajpregu.1990.259.1.R184 |
0.354 |
|
| 1989 |
Platt KA, Min HY, Ross SR, Spiegelman BM. Obesity-linked regulation of the adipsin gene promoter in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 86: 7490-4. PMID 2798420 DOI: 10.1073/pnas.86.19.7490 |
0.308 |
|
| 1989 |
Flier JS, Lowell B, Napolitano A, Usher P, Rosen B, Cook KS, Spiegelman B. Adipsin: regulation and dysregulation in obesity and other metabolic states. Recent Progress in Hormone Research. 45: 567-80; discussion 5. PMID 2682848 DOI: 10.1016/B978-0-12-571145-6.50017-0 |
0.41 |
|
| 1989 |
Johnson RS, Sheng M, Greenberg ME, Kolodner RD, Papaioannou VE, Spiegelman BM. Targeting of nonexpressed genes in embryonic stem cells via homologous recombination. Science (New York, N.Y.). 245: 1234-6. PMID 2506639 DOI: 10.1126/Science.2506639 |
0.549 |
|
| 1979 |
Spiegelman BM, Lopata MA, Kirschner MW. Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells. Cell. 16: 253-63. PMID 455435 DOI: 10.1016/0092-8674(79)90003-5 |
0.402 |
|
| 1979 |
Spiegelman BM, Lopata MA, Kirschner MW. Multiple sites for the initiation of microtubule assembly in mammalian cells. Cell. 16: 239-52. PMID 455434 DOI: 10.1016/0092-8674(79)90002-3 |
0.375 |
|
| 1979 |
Cleveland DW, Spiegelman BM, Kirschner MW. Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. The Journal of Biological Chemistry. 254: 12670-8. PMID 227904 |
0.528 |
|
| 1977 |
Spiegelman BM, Penningroth SM, Kirschner MW. Turnover of tubulin and the N site GTP in Chinese hamster ovary cells. Cell. 12: 587-600. PMID 562716 DOI: 10.1016/0092-8674(77)90259-8 |
0.39 |
|
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