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25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Gierse RM, Redeem E, Diamanti E, Wrenger C, Groves MR, Hirsch AK. DXS as a target for structure-based drug design. Future Medicinal Chemistry. 9: 1277-1294. PMID 28636418 DOI: 10.4155/Fmc-2016-0239  0.395
2017 Scheepstra M, Andrei SA, Unver MY, Hirsch AK, Leysen S, Ottmann C, Brunsveld L, Milroy LG. Designed Spiroketal Protein Modulation. Angewandte Chemie (International Ed. in English). PMID 28407400 DOI: 10.1002/Anie.201612504  0.371
2017 Liu Y, Lehn JM, Hirsch AK. Molecular Biodynamers: Dynamic Covalent Analogues of Biopolymers. Accounts of Chemical Research. PMID 28169527 DOI: 10.1021/Acs.Accounts.6B00594  0.468
2017 Dockerty P, Edens JG, Tol MB, Morales Angeles D, Domenech A, Liu Y, Hirsch AK, Veening JW, Scheffers DJ, Witte MD. Bicyclic enol cyclocarbamates inhibit penicillin-binding proteins. Organic & Biomolecular Chemistry. PMID 28045164 DOI: 10.1039/C6Ob01664B  0.392
2016 Wieczorek S, Remmler D, Masini T, Kochovski Z, Hirsch AK, Boerner HG. Equipping nanocarriers specifically toward cargo: A competitive study on solubilizing related photosensitizers for photodynamic therapy. Bioconjugate Chemistry. PMID 28002941 DOI: 10.1021/Acs.Bioconjchem.6B00549  0.334
2016 Mondal M, Unver MY, Pal A, Bakker M, Berrier SP, Hirsch AK. Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and -Optimization of Inhibitors of the Aspartic Protease Endothiapepsin. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27604032 DOI: 10.1002/Chem.201603001  0.371
2016 Masini T, Birkaya B, van Dijk S, Mondal M, Hekelaar J, Jäger M, Terwisscha van Scheltinga AC, Patel MS, Hirsch AK, Moman E. Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site. Journal of Enzyme Inhibition and Medicinal Chemistry. 1-6. PMID 27435185 DOI: 10.1080/14756366.2016.1201812  0.354
2016 Mondal M, Radeva N, Fanlo-Virgós H, Otto S, Klebe G, Hirsch AK. Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry. Angewandte Chemie (International Ed. in English). PMID 27400756 DOI: 10.1002/Anie.201603074  0.381
2015 Monjas L, Hirsch AK. Harnessing dynamic combinatorial chemistry in the search for new ligands for protein targets. Future Medicinal Chemistry. PMID 26510895 DOI: 10.4155/Fmc.15.146  0.319
2015 Masini T, Lacy B, Monjas L, Hawksley D, de Voogd AR, Illarionov B, Iqbal A, Leeper FJ, Fischer M, Kontoyianni M, Hirsch AK. Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS. Organic & Biomolecular Chemistry. PMID 26411373 DOI: 10.1039/C5Ob01666E  0.335
2015 Hartman AM, Mondal M, Radeva N, Klebe G, Hirsch AK. Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin. International Journal of Molecular Sciences. 16: 19184-94. PMID 26287174 DOI: 10.3390/Ijms160819184  0.372
2015 Huizing AP, Mondal M, Hirsch AK. Fighting Malaria: Structure-Guided Discovery of Nonpeptidomimetic Plasmepsin Inhibitors. Journal of Medicinal Chemistry. 58: 5151-63. PMID 25719272 DOI: 10.1021/Jm5014133  0.391
2015 Mondal M, Hirsch AK. Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets. Chemical Society Reviews. 44: 2455-88. PMID 25706945 DOI: 10.1039/C4Cs00493K  0.348
2015 Swier LJ, Monjas L, Guskov A, de Voogd AR, Erkens GB, Slotboom DJ, Hirsch AK. Structure-based design of potent small-molecule binders to the S-component of the ECF transporter for thiamine. Chembiochem : a European Journal of Chemical Biology. 16: 819-26. PMID 25676607 DOI: 10.1002/Cbic.201402673  0.325
2015 Wieczorek S, Vigne S, Masini T, Ponader D, Hartmann L, Hirsch AK, Börner HG. Combinatorial screening for specific drug solubilizers with switchable release profiles. Macromolecular Bioscience. 15: 82-9. PMID 25557786 DOI: 10.1002/Mabi.201400443  0.32
2014 Masini T, Hirsch AK. Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents. Journal of Medicinal Chemistry. 57: 9740-63. PMID 25210872 DOI: 10.1021/Jm5010978  0.345
2014 Scheepstra M, Nieto L, Hirsch AK, Fuchs S, Leysen S, Lam CV, in het Panhuis L, van Boeckel CA, Wienk H, Boelens R, Ottmann C, Milroy LG, Brunsveld L. A natural-product switch for a dynamic protein interface. Angewandte Chemie (International Ed. in English). 53: 6443-8. PMID 24821627 DOI: 10.1002/Anie.201403773  0.348
2014 Mondal M, Radeva N, Köster H, Park A, Potamitis C, Zervou M, Klebe G, Hirsch AK. Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry. Angewandte Chemie (International Ed. in English). 53: 3259-63. PMID 24532096 DOI: 10.1002/Anie.201309682  0.393
2014 Hirsch AK, Reutenauer P, Le Moignan M, Ulrich S, Boul PJ, Harrowfield JM, Jarowski PD, Lehn JM. Theoretical and structural analysis of long C-C bonds in the adducts of polycyanoethylene and anthracene derivatives and their connection to the reversibility of Diels-Alder reactions. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 1073-80. PMID 24339005 DOI: 10.1002/Chem.201303276  0.395
2013 Wieczorek S, Krause E, Hackbarth S, Röder B, Hirsch AK, Börner HG. Exploiting specific interactions toward next-generation polymeric drug transporters. Journal of the American Chemical Society. 135: 1711-4. PMID 23305453 DOI: 10.1021/Ja311895Z  0.308
2012 van der Meer JY, Hirsch AK. The isoprenoid-precursor dependence of Plasmodium spp. Natural Product Reports. 29: 721-8. PMID 22555616 DOI: 10.1039/C2Np20013A  0.359
2012 Hirsch AK, Buhler E, Lehn JM. Biodynamers: self-organization-driven formation of doubly dynamic proteoids. Journal of the American Chemical Society. 134: 4177-83. PMID 22300496 DOI: 10.1021/Ja2099134  0.427
2008 Crane CM, Hirsch AK, Alphey MS, Sgraja T, Lauw S, Illarionova V, Rohdich F, Eisenreich W, Hunter WN, Bacher A, Diederich F. Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis. Chemmedchem. 3: 91-101. PMID 18033714 DOI: 10.1002/Cmdc.200700208  0.496
2007 Hirsch A, Fischer F, Diederich F. Molekulare Erkennung von Phosphaten in der Strukturbiologie Angewandte Chemie. 119: 342-357. DOI: 10.1002/Ange.200603420  0.521
2006 Sneddon HF, van den Heuvel A, Hirsch AK, Booth RA, Shaw DM, Gaunt MJ, Ley SV. Double conjugate addition of dithiols to propargylic carbonyl systems to generate protected 1,3-dicarbonyl compounds. The Journal of Organic Chemistry. 71: 2715-25. PMID 16555825 DOI: 10.1021/Jo052514S  0.385
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