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Year Citation  Score
2004 Kumar R, Garneau P, Nguyen N, Lown JW, Pelletier J. Methionine sustituted polyamides are RNAse mimics that inhibit translation Journal of Drug Targeting. 12: 125-134. PMID 15203891 DOI: 10.1080/1061186042000220728  0.304
2004 Iida H, Hayashi N, Lown JW, Matsumoto K. Design and synthesis of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates by the use of SNAr reaction of 2-nitro-5-fluorobenzoate precursor as key reaction Heterocycles. 62: 693-711. DOI: 10.3987/Com-03-S(P)69  0.382
2003 Kumar R, Lown JW. Design, synthesis and in vitro cytotoxicity studies of novel pyrrolo [2,1][1,4] benzodiazepine-glycosylated pyrrole and imidazole polyamide conjugates. Organic & Biomolecular Chemistry. 1: 3327-42. PMID 14584797 DOI: 10.1039/B306685A  0.305
2003 Kumar R, Lown JW. Synthesis and cytotoxicity evaluation of novel C7-C7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates Organic and Biomolecular Chemistry. 1: 2630-2647. PMID 12948187 DOI: 10.1039/B303650M  0.307
2002 Sharma SK, Billaud JN, Tandon M, Billet O, Choi S, Kopka ML, Phillips TR, Lown JW. Inhibition of feline immunodeficiency virus (FIV) replication by DNA binding polyamides Bioorganic and Medicinal Chemistry Letters. 12: 2007-2010. PMID 12113829 DOI: 10.1016/S0960-894X(02)00307-4  0.346
2002 Kumar R, Rai D, Ko SCC, Lown JW. Synthesis of novel thiazole-containing bis-1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI)-polyamide conjugates as anticancer agents Heterocyclic Communications. 8: 521-530. DOI: 10.1515/Hc.2002.8.6.521  0.32
2002 Kumar R, Lown JW. Design and synthesis of novel DNA interstrand cross-linking agents: C2-linked pyrrolo[2,1-c][1,4]benzodiazepine polyamide conjugates Heterocyclic Communications. 8: 115-122. DOI: 10.1515/Hc.2002.8.2.115  0.395
2002 Kumar R, Reddy BSN, Lown JW. Design and synthesis of novel pyrrolo[2,1-c][1,4]benzodiazepine - Imidazole containing polyamide conjugates Heterocyclic Communications. 8: 19-26. DOI: 10.1515/Hc.2002.8.1.19  0.321
2002 Sharma SK, Lown JW. Solid-phase synthesis of a folate conjugate of a DNA binding polyamide Tetrahedron Letters. 43: 6665-6667. DOI: 10.1016/S0040-4039(02)01448-X  0.391
2002 Sharma SK, Tandon M, Lown JW. Design and synthesis of new thiazolated cross-linked DNA binding polyamides for altered sequence recognition Tetrahedron. 58: 3417-3421. DOI: 10.1016/S0040-4020(02)00285-5  0.375
2001 Sapse AM, Rothchild R, Kumar R, Lown JW. Ab initio studies of the reaction of hydrogen transfer from DNA to the calicheamicinone diradical Molecular Medicine. 7: 797-802. PMID 11844867 DOI: 10.1007/Bf03401971  0.403
2001 Reddy BSP, Sharma SK, Lown JW. Recent developments in sequence selective minor groove DNA effectors Current Medicinal Chemistry. 8: 475-508. PMID 11281837  0.327
2001 Sharma SK, Morrissey AT, Miller GG, Gmeiner WH, Lown JW. Design, synthesis, and intracellular localization of a fluorescently labeled DNA binding polyamide related to the antibiotic distamycin Bioorganic and Medicinal Chemistry Letters. 11: 769-772. PMID 11277516 DOI: 10.1016/S0960-894X(01)00064-6  0.32
2001 Helm M, Kopka ML, Sharma SK, Lown JW, Giegé R. RNase activity of a DNA minor groove binder with a minimalist catalytic motif from RNase A. Biochemical and Biophysical Research Communications. 281: 1283-90. PMID 11243875 DOI: 10.1006/Bbrc.2001.4503  0.376
2000 Burckhardt G, Förtsch I, Simon H, Birch-Hirschfeld E, Kittler L, Schütz H, Sharma SK, Lown JW, Zimmer C. DNA Sequence Recognition of a Cross-Linked Polyamide: CD Studies, Footprinting and Effects on the Activity of DNA Gyrase. Journal of Biomolecular Structure & Dynamics. 17: 355-63. PMID 22607444 DOI: 10.1080/07391102.2000.10506641  0.361
2000 Gmeiner WH, Cui W, Sharma S, Soto AM, Marky LA, Lown JW. Shape-selective binding of geometrically-constrained bis-distamycins to a DNA duplex and a model Okazaki fragment of identical sequence Nucleosides, Nucleotides and Nucleic Acids. 19: 1365-1379. PMID 11097065 DOI: 10.1080/15257770008033058  0.357
2000 Jia G, Lown JW. Design, synthesis and cytotoxicity evaluation of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers Bioorganic and Medicinal Chemistry. 8: 1607-1617. PMID 10976508 DOI: 10.1016/S0968-0896(00)00088-2  0.309
2000 Sharma SK, Tandon M, Lown JW. Design and synthesis of novel thiazole-containing cross-linked polyamides related to the antiviral antibiotic distamycin Journal of Organic Chemistry. 65: 1102-1107. PMID 10814060 DOI: 10.1021/Jo991571G  0.432
2000 Matsumoto K, Iida H, Lown JW. Synthesis of polyaminoalkyl substituted conjugates of pyrrolo[2,1- c][1,4]benzodiazepine involving S(N)Ar reaction of 2-nitro-5-fluorobenzoate precursors Heterocycles. 52: 1015-1020. DOI: 10.3987/Com-99-S116  0.333
2000 Sharma SK, Tandon M, Lown JW. Synthesis of geometrically constrained unsymmetrical bis(polyamides) related to the antiviral distamycin European Journal of Organic Chemistry. 2095-2103. DOI: 10.1002/1099-0690(200006)2000:11<2095::Aid-Ejoc2095>3.0.Co;2-J  0.303
1999 Damayanthi Y, Praveen Reddy BS, Lown JW. Design and Synthesis of Novel Pyrrolo[2,1-c][1,4]benzodiazepine-Lexitropsin Conjugates. The Journal of Organic Chemistry. 64: 290-292. PMID 11674116 DOI: 10.1021/Jo9812072  0.306
1999 Gmeiner WH, Cui W, Konerding DE, Keifer PA, Sharma SK, Soto AM, Marky LA, Lown JW. Shape-selective recognition of a model Okazaki fragment by geometrically-constrained bis-distamycins Journal of Biomolecular Structure and Dynamics. 17: 507-518. PMID 10636085 DOI: 10.1080/07391102.1999.10508381  0.373
1999 Reddy BSP, Sondhi SM, Lown JW. Synthetic DNA minor groove-binding drugs Pharmacology and Therapeutics. 84: 1-111. PMID 10580832 DOI: 10.1016/S0163-7258(99)00021-2  0.356
1999 Iida H, Misumi Y, Morishita T, Matsumoto K, Lown JW. SNAr REACTIONS OF METHYL AND ETHYL 2-NITRO-5-FLUOROBENZOATES IN THE SYNTHESIS OF PYRRO[2,1-c][1.4]BENZODIAZEPINE PRECURSORS Heterocyclic Communications. 5. DOI: 10.1515/Hc.1999.5.6.509  0.322
1999 Reddy BSP, Damayanthi Y, Lown JW. Design and efficient synthesis of novel DNA interstrand cross-linking agents: C2-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers Synlett. 1112-1114. DOI: 10.1055/S-1999-2769  0.394
1999 Jia G, Iida H, Lown JW. Synthesis of an unsymmetrical bis-lexitropsin-1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI) conjugate Chemical Communications. 119-120. DOI: 10.1039/A807884J  0.306
1999 Ding Q, Lown JW. Novel amination and 1,2-amino,hydro-elimination between 2,3- diketopyrido[4,3,2-de]quinolines and primary amino compounds Journal of Organic Chemistry. 64: 7965-7972. DOI: 10.1021/Jo9910132  0.328
1998 Neamati N, Mazumder A, Sunder S, Owen JM, Tandon M, Lown JW, Pommier Y. Highly potent synthetic polyamides, bisdistamycins, and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase Molecular Pharmacology. 54: 280-290. PMID 9687569 DOI: 10.1124/Mol.54.2.280  0.332
1998 Zhao R, Lown JW. Synthesis of bioreductively activated alkylating Hoechst 33258 analogues Heterocyclic Communications. 4: 11-19. DOI: 10.1515/Hc.1998.4.1.11  0.318
1998 Singh AK, Lown JW. Synthesis of substituted imidazo[4,5-b]pyridines as analogues of the DNA binding fluorochrome Hoechst 33258 Synthetic Communications. 28: 4059-4066.  0.305
1997 Wang Z, Zimmer C, Lown JW, Knippers R. Effects of bifunctional netropsin-related minor groove-binding ligands on mammalian type I DNA topoisomerase. Biochemical Pharmacology. 53: 309-16. PMID 9065734 DOI: 10.1016/S0006-2952(96)00690-9  0.44
1997 Zhao R, al-Said NH, Sternbach DL, Lown JW. Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro. Journal of Medicinal Chemistry. 40: 216-25. PMID 9003520 DOI: 10.1021/Jm9605804  0.306
1997 Zhao R, Lown JW. A concise synthesis of the pyrroloquinoline nucleus of the makaluvamine alkaloids Synthetic Communications. 27: 2103-2110. DOI: 10.1080/00397919708006817  0.302
1996 Gupta R, Liu J, Xie G, Lown JW. Novel DNA-directed alkylating agents consisting of naphthalimide, nitrogen mustard and lexitropsin moieties: synthesis, DNA sequence specificity and biological evaluation. Anti-Cancer Drug Design. 11: 581-96. PMID 9022747  0.321
1996 Diwu ZJ, Haugland RP, Liu J, Lown JW, Miller GG, Moore RB, Brown K, Tulip J, McPhee MS. Photosensitization by anticancer agents 21: new perylene- and aminonaphthoquinones. Free Radical Biology & Medicine. 20: 589-93. PMID 8904300 DOI: 10.1016/0891-5849(95)02061-6  0.304
1996 Yang Y, Chen YH, Pon RT, Lown JW. Studies on cooperative binding of an extended distamycin A analogue in the minor groove of DNA by NMR spectroscopy. Biochemical and Biophysical Research Communications. 222: 764-9. PMID 8651919 DOI: 10.1006/Bbrc.1996.0818  0.415
1996 Chen YH, Yang Y, Lown JW. Design of distamicin analogues to probe the physical origin of the antiparallel side by side oligopeptide binding motif in DNA minor groove recognition. Biochemical and Biophysical Research Communications. 220: 213-8. PMID 8602847 DOI: 10.1006/Bbrc.1996.0383  0.322
1996 Zhao R, Oreski B, Lown JW. Synthesis and biological evaluation of hybrid molecules containing the pyrroloquinoline nucleus and DNA-minor groove binders Bioorganic and Medicinal Chemistry Letters. 6: 2169-2172. DOI: 10.1016/0960-894X(96)00395-2  0.396
1996 Singh MP, Wylie WA, Lown JW. Structural characterization of side-by-side binding for a cross-linked lexitropsin dimer designed to target G · C base pairs in the DNA minor groove Magnetic Resonance in Chemistry. 34: S55-S66. DOI: 10.1002/(Sici)1097-458X(199612)34:133.0.Co;2-C  0.378
1995 Huang L, Quada JC, Lown JW. Design, synthesis and sequence selective DNA cleavage of functional models of bleomycin--II. 1,2-trans-disubstituted cyclopropane units as novel linkers. Bioorganic & Medicinal Chemistry. 3: 647-57. PMID 7582943 DOI: 10.1016/0968-0896(95)00058-O  0.43
1995 Chen YH, Lown JW. Design and synthesis of sequence-specific DNA minor groove recognizing ligands of the cross-linked lexitropsin class Heterocycles. 41: 1691-1707. DOI: 10.3987/Com-95-7079  0.379
1995 Huang L, Quada JC, Lown JW. Synthesis of designed bleomycin models with different dna recognition sites Heterocyclic Communications. 1: 335-340. DOI: 10.1515/Hc.1995.1.5-6.335  0.369
1995 Al-Said NH, Lown JW. A convenient synthesis of cross-linked homodimeric bis-lexitropsins Synthetic Communications. 25: 1059-1070. DOI: 10.1080/00397919508012668  0.36
1995 Liu J, Diwu Z, Lown JW. Efficient synthesis of a novel perylenequinone and its dimethyl ether derivatives Synthesis. 914-916. DOI: 10.1055/S-1995-4047  0.304
1995 Zhao R, Oreski B, Lown JW. Synthesis and antitumor activity of camptothecin derivatives bearing five-membered heterocycle containing 10-substituents Bioorganic and Medicinal Chemistry Letters. 5: 3063-3066. DOI: 10.1016/0960-894X(95)00538-5  0.329
1995 Matsumoto K, Ikemi Y, Kakehi A, Shigihara A, Lown JW. Reaction of 3-aroylaziridines with diphenylcyclopropenone and subsequent stereospecific 1,3-dipolar cycloaddition of the adducts with dimethyl 1-cyclobutene 1,2-dicarboxylate Tetrahedron Letters. 36: 5295-5298. DOI: 10.1016/0040-4039(95)01018-D  0.318
1995 Plouvier B, Singh MP, Lown JW. Synthesis and NMR characterization of selectively 15N-labelled trans- and cis-butenediamido-linked bis-netropsins Journal of Labelled Compounds and Radiopharmaceuticals. 36: 345-359. DOI: 10.1002/Jlcr.2580360407  0.329
1995 Lown JW. Design and development of sequence selective lexitropsin DNA minor groove binders Drug Development Research. 34: 145-183. DOI: 10.1002/Ddr.430340207  0.37
1995 Zhao R, Lown JW. Synthesis of a novel N-methoxymethylpyrrole-containing DNA minor groove binding oligopeptide related to distamycin Heterocycles. 41: 337-344.  0.301
1994 Diwu Z, Lown JW. Phototherapeutic potential of alternative photosensitizers to porphyrins. Pharmacology & Therapeutics. 63: 1-35. PMID 7972342 DOI: 10.1016/0163-7258(94)90054-X  0.311
1994 Gupta R, Xie G, Lown JW. Hybrid molecules containing propargylic sulfones and DNA minor groove-binding lexitropsins: synthesis, sequence specificity of reaction with DNA and biological evaluation. Gene. 149: 81-90. PMID 7958991 DOI: 10.1016/0378-1119(94)90415-4  0.313
1994 Bailly C, Colson P, Houssier C, Wang H, Bathini Y, Lown JW. Mode of DNA binding of bis-benzimidazoles and related structures studied by electric linear dichroism. Journal of Biomolecular Structure & Dynamics. 12: 173-81. PMID 7848566 DOI: 10.1080/07391102.1994.10508095  0.396
1994 Lown JW. DNA recognition by lexitropsins, minor groove binding agents. Journal of Molecular Recognition : Jmr. 7: 79-88. PMID 7826677 DOI: 10.1002/Jmr.300070205  0.375
1994 Singh MP, Plouvier B, Hill GC, Gueck J, Pon RT, Lown JW. Isohelicity and strand selectivity in the minor groove binding of chiral (1R,2R)- and (1S,2S)-bis(netropsin)-1,2-cyclopropanedicarboxamide ligands to duplex DNA Journal of the American Chemical Society. 116: 7006-7020. DOI: 10.1021/Ja00095A002  0.32
1994 Chen YH, Lown JW. A new DNA minor groove binding motif: Cross-linked lexitropsins Journal of the American Chemical Society. 116: X-7003. DOI: 10.1021/Ja00095A001  0.382
1994 Al-Said NH, Lown JW. Synthesis of novel cross-linked bis-lexitropsins Tetrahedron Letters. 35: 7577-7580. DOI: 10.1016/S0040-4039(00)78347-X  0.41
1994 Huang L, Quada JC, Lown JW. Design and synthesis of DNA cleaving bleomycin models: 1,2-trans-disubstituted cyclopropane units as novel linkers Tetrahedron Letters. 35: 5323-5326. DOI: 10.1016/S0040-4039(00)73490-3  0.404
1994 Wang H, Al-Said NH, Lown JW. Convenient syntheses of pyrroloiminoquinone and its lexitropsin-linked derivative Tetrahedron Letters. 35: 4085-4086. DOI: 10.1016/S0040-4039(00)73118-2  0.312
1993 Huang L, Morgan A, Lown J. Design of DNA-cleaving molecules which incorporate a simplified metal-complexing moiety of bleomycin and lexitropsin carriers Bioorganic & Medicinal Chemistry Letters. 3: 1751-1756. DOI: 10.1016/S0960-894X(00)80056-6  0.566
1993 Xie G, Morgan A, Lown J. Synthesis and DNA cleaving properties of hybrid molecules containing propargylic sulfones and minor groove binding lexitropsins Bioorganic & Medicinal Chemistry Letters. 3: 1565-1570. DOI: 10.1016/S0960-894X(00)80019-0  0.6
1993 Liu J, Diwu Z, Lown J. Synthetic studies in novel hypocrellin B derivatives Tetrahedron. 49: 10785-10792. DOI: 10.1016/S0040-4020(01)80233-7  0.303
1993 Matsumoto K, Uchida T, Toda M, Aoyama K, Kakehi A, Shigihara A, Lown JW. Reaction of dicyanomethylides with 3-(3′,3′-dimethyltriazene-1-yl)- pyridine-4-carboxylic acid. Unexpected preferential formation of pyrido[4,3-a]indolizines Tetrahedron Letters. 33: 7643-7646. DOI: 10.1016/0040-4039(93)88005-4  0.331
1992 Rao KE, Lown JW. Molecular recognition between ligands and nucleic acids: DNA binding characteristics of analogues of Hoechst 33258 designed to exhibit altered base and sequence recognition. Chemical Research in Toxicology. 4: 661-9. PMID 1725495 DOI: 10.1021/tx00024a011  0.321
1992 Rao KE, Krowicki K, Burckhardt G, Zimmer C, Lown JW. Molecular recognition between oligopeptides and nucleic acids: DNA binding selectivity of a series of 1,2,4-triazole-containing lexitropsins. Chemical Research in Toxicology. 4: 241-52. PMID 1664260 DOI: 10.1021/Tx00020A019  0.422
1992 Kumar S, Bathini Y, Joseph T, Pon RT, Lown JW. Structural and dynamic aspects of non-intercalative (1:1) binding of a thiazole-lexitropsin to the decadeoxyribonucleotide d-[CGCAATTGCG]2: An 1H-NMR and molecular modeling study. Journal of Biomolecular Structure & Dynamics. 9: 1-21. PMID 1664210 DOI: 10.1080/07391102.1991.10507890  0.382
1992 Rao KE, Lown JW. DNA sequence selectivities in the covalent bonding of antibiotic saframycins Mx1, Mx3, A, and S deduced from MPE.Fe(II) footprinting and exonuclease III stop assays. Biochemistry. 31: 12076-82. PMID 1457404 DOI: 10.1021/Bi00163A016  0.352
1992 Bailly C, Colson P, Houssier C, Houssin R, Mrani D, Gosselin G, Imbach JL, Waring MJ, Lown JW, Hénichart JP. Binding properties and DNA sequence-specific recognition of two bithiazole-linked netropsin hybrid molecules. Biochemistry. 31: 8349-62. PMID 1381962  0.318
1992 Beerman TA, McHugh MM, Sigmund R, Lown JW, Rao KE, Bathini Y. Effects of analogs of the DNA minor groove binder Hoechst 33258 on topoisomerase II and I mediated activities. Biochimica Et Biophysica Acta. 1131: 53-61. PMID 1374646 DOI: 10.1016/0167-4781(92)90098-K  0.316
1992 Reszka KJ, Bilski P, Chignell CF, Hartley JA, Khan N, Souhami RL, Mendonca AJ, Lown JW. Photosensitization by anticancer agents. 11. Mechanisms of photosensitization of human leukemic cells by diaminoanthraquinones: singlet oxygen and radical reactions. Journal of Photochemistry and Photobiology. B, Biology. 15: 317-35. PMID 1331388 DOI: 10.1016/1011-1344(92)85138-K  0.348
1992 Singh MP, Kumar S, Joseph T, Pon RT, Lown JW. A 1H-NMR study of the DNA binding characteristics of thioformyldistamycin, an amide isosteric lexitropsin. Biochemistry. 31: 6453-61. PMID 1321661 DOI: 10.1021/Bi00143A014  0.399
1992 Adnet F, Liquier J, Taillandier E, Singh MP, Rao KE, Lown JW. FTIR study of specific binding interactions between DNA minor groove binding ligands and polynucleotides. Journal of Biomolecular Structure & Dynamics. 10: 565-75. PMID 1283517 DOI: 10.1080/07391102.1992.10508668  0.356
1992 Sondhi SM, Magan A, Lown JW. Synthesis of a Series of Acodazole and Naphthothiophene-Deuterioporphyrins and Metalloporphyrins Bulletin of the Chemical Society of Japan. 65: 579-585. DOI: 10.1246/Bcsj.65.579  0.387
1992 Dwyer TJ, Geierstanger BH, Bathini Y, Lown JW, Wemmer DE. Design and binding of a distamycin A analog to d(CGCAAGTTGGC)·d)GCCAACTTGCG): Synthesis, NMR studies, and implications for the design of sequence-specific minor groove binding oligopeptides Journal of the American Chemical Society. 114: 5911-5919. DOI: 10.1021/Ja00041A001  0.369
1991 Bathini Y, Rao KE, Shea RG, Lown JW. Molecular recognition between ligands and nucleic acids: novel pyridine- and benzoxazole-containing agents related to Hoechst 33258 that exhibit altered DNA sequence specificity deduced from footprinting analysis and spectroscopic studies. Chemical Research in Toxicology. 3: 268-80. PMID 1720029 DOI: 10.1021/tx00015a013  0.319
1991 Kumar S, Yadagiri B, Zimmermann J, Pon RT, Lown JW. Sequence specific molecular recognition and binding by a GC recognizing Hoechst 33258 analogue to the decadeoxyribonucleotide d-[CATGGCCATG]2: structural and dynamic aspects deduced from high field 1H-NMR studies. Journal of Biomolecular Structure & Dynamics. 8: 331-57. PMID 1702637 DOI: 10.1080/07391102.1990.10507809  0.366
1991 Bathini Y, Lown JW. A Convenient Synthesis of Substituted Oxazolo-[5,4-b]Pyridines Using Lead Tetraacetate as Oxidative Cyclizing Agent Synthetic Communications. 21: 215-222. DOI: 10.1080/00397919108020814  0.386
1991 Rao KE, Zimmermann J, Lown JW. Sequence-selective DNA binding by linked bis-N-methylpyrrole dipeptides: an analysis by methidium propyl-EDTA (MPE) footprinting and force-field calculations The Journal of Organic Chemistry. 56: 786-797. DOI: 10.1021/Jo00002A053  0.34
1990 Kotovych G, Lown JW, Tong JP. High-field 1H and 31P NMR studies on the binding of the anticancer agent mitoxantrone to d[CpGpApTpCpG]2. Journal of Biomolecular Structure & Dynamics. 4: 111-25. PMID 3271431 DOI: 10.1080/07391102.1986.10507649  0.314
1990 Lee M, Huss S, Gosselin G, Imbach JL, Hartley JA, Lown JW. Structure and conformation of the branch core triribonucleotide containing 2'-5' and 3'-5' phosphodiester linkages (A 2'p5'G 3'p5'C) i solution, essential for yeast mRNA splicing, deduced from 1H-NMR. Journal of Biomolecular Structure & Dynamics. 5: 651-68. PMID 3078236 DOI: 10.1080/07391102.1987.10506418  0.315
1990 Lee M, Pon RT, Krowicki K, Lown JW. Structural and dynamic aspects of the sequence specific binding of netropsin and its bis-imidazole analogue on the decadeoxyribonucleotide d-[CGCAATTGCG]2. Journal of Biomolecular Structure & Dynamics. 5: 939-49. PMID 2856031 DOI: 10.1080/07391102.1988.10506436  0.406
1990 Lee M, Krowicki K, Shea RG, Lown JW, Pon RT. Molecular recognition between oligopeptides and nucleic acids. Specificity of binding of a monocationic bis-furan lexitropsin to DNA deduced from footprinting and 1H NMR studies. Journal of Molecular Recognition : Jmr. 2: 84-93. PMID 2561528 DOI: 10.1002/Jmr.300020206  0.388
1990 Bailly C, Helbecque N, Hénichart JP, Colson P, Houssier C, Rao KE, Shea RG, Lown JW. Molecular recognition between oligopeptides and nucleic acids. DNA sequence specificity and binding properties of an acridine-linked netropsin hybrid ligand. Journal of Molecular Recognition : Jmr. 3: 26-35. PMID 2354061 DOI: 10.1002/Jmr.300030103  0.345
1990 Kissinger KL, Dabrowiak JC, Lown JW. Molecular recognition between oligopeptides and nucleic acids: DNA binding specificity of a series of bis netropsin analogues deduced from footprinting analysis Chemical Research in Toxicology. 3: 162-168. PMID 1966670 DOI: 10.1021/Tx00014A013  0.301
1990 Yadagiri B, Lown JW. Convenient Routes to Substituted Benzimidazoles and Imidazolo[4,5-b]pyridines Using Nitrobenzene as Oxidant Synthetic Communications. 20: 955-963. DOI: 10.1080/00397919008052798  0.386
1990 Yadagiri B, Lown JW. Selective Cleavage of Benzoxazoles to o-Hydroxy-N-Substituted Anilines with Sodium Borohydride-Acetic Acid Synthetic Communications. 20: 175-181. DOI: 10.1080/00397919008052281  0.312
1990 Rao KE, Bathini Y, Lown JW. Synthesis of novel thiazole-containing DNA minor groove binding oligopeptides related to the antibiotic distamycin The Journal of Organic Chemistry. 55: 728-737. DOI: 10.1021/Jo00289A057  0.444
1990 Naghipur A, Ikonomou MG, Kebarle P, Lown JW. Mechanism of action of (2-haloethyl)nitrosoureas on DNA: discrimination between alternative pathways of DNA base modification by 1,3-bis(2-fluoroethyl)-1-nitrosourea by using specific deuterium labeling and identification of reaction products by HPLC/tandem mass spectrometry Journal of the American Chemical Society. 112: 3178-3187. DOI: 10.1021/Ja00164A046  0.386
1989 Lown JW, Hanstock CC. High field 1H-NMR analysis of the 1:1 intercalation complex of the antitumor agent mitoxantrone and the DNA duplex [d(CpGpCpG)]. Journal of Biomolecular Structure & Dynamics. 2: 1097-106. PMID 3916943 DOI: 10.1080/07391102.1985.10507626  0.35
1989 Hartley JA, Lown JW, Mattes WB, Kohn KW. DNA sequence specificity of antitumor agents. Oncogenes as possible targets for cancer therapy. Acta Oncologica (Stockholm, Sweden). 27: 503-10. PMID 2849464 DOI: 10.3109/02841868809093578  0.319
1989 Carminati A, Barascut J, Naghipur A, Lown JW, Imbach J. Pathways and kinetics of aqueous decomposition and carbamoylating activity of new anticancer nitroimidazole-linked 2-chloroethylnitrosoureas. Biochemical Pharmacology. 38: 2253-2258. PMID 2751691 DOI: 10.1016/0006-2952(89)90462-0  0.329
1989 Bailly C, Catteau JP, Hénichart JP, Reszka K, Shea RG, Krowicki K, Lown JW. Subcellular distribution of a nitroxide spin-labeled netropsin in living KB cells. Electron paramagnetic resonance and sequence specificity studies. Biochemical Pharmacology. 38: 1625-30. PMID 2543417 DOI: 10.1016/0006-2952(89)90310-9  0.356
1988 Lee M, Coulter DM, Pon RT, Krowicki K, Lown JW. Sequence specific molecular recognition and binding of a monocationic bis-imidazolelexitropsin to the decadeoxyribonucleotide d- [(Gatccgtatg) (catacggatc)]:Structural and dynamic aspects of intermolecular exchange studied by ^-nmr Journal of Biomolecular Structure and Dynamics. 5: 1059-1088. PMID 2856032 DOI: 10.1080/07391102.1988.10506449  0.407
1988 Krowicki K, Balzarini J, De Clercq E, Newman RA, Lown JW. Novel DNA groove binding alkylators: design, synthesis, and biological evaluation. Journal of Medicinal Chemistry. 31: 341-5. PMID 2828620 DOI: 10.1021/Jm00397A012  0.395
1988 Sondhi SM, Kolodziejczyk P, Ball RG, Lown JW. Naphtho[2,1-b]thiophene-linked 1,2-dithia-5,8-diazacyclodecanes and imidazolidino[1,2-d]dithiazepines: synthesis, structure proof by x-ray diffraction analysis, and DNA binding properties The Journal of Organic Chemistry. 53: 4310-4314. DOI: 10.1021/Jo00253A023  0.348
1988 Lee M, Krowicki K, Hartley JA, Pon RT, Lown JW. Molecular recognition between oligopeptides and nucleic acids: influence of van der Waals contacts in determining the 3'-terminus of DNA sequences read by monocationic lexitropsins Journal of the American Chemical Society. 110: 3641-3649. DOI: 10.1021/Ja00219A045  0.336
1987 Kissinger K, Krowicki K, Dabrowiak JC, Lown JW. Molecular recognition between oligopeptides and nucleic acids. Monocationic imidazole lexitropsins that display enhanced GC sequence dependent DNA binding Biochemistry. 26: 5590-5595. PMID 2823885 DOI: 10.1021/Bi00392A002  0.396
1987 Krowicki K, Lown JW. Synthesis of novel imidazole-containing DNA minor groove binding oligopeptides related to the antiviral antibiotic netropsin Journal of Organic Chemistry. 52: 3493-3501. DOI: 10.1021/Jo00392A001  0.418
1986 Krishnamoorthy CR, Yen SF, Smith JC, Lown JW, Wilson WD. Stopped-flow kinetic analysis of the interaction of anthraquinone anticancer drugs with calf thymus DNA, poly[d(G-C)].cntdot.poly[d(G-C)], and poly[d(A-T)].cntdot.poly[d(A-T)] Biochemistry. 25: 5933-5940. PMID 3790495 DOI: 10.1021/Bi00368A015  0.338
1986 Parker S, Kirk MC, Ludlum DB, Koganty RR, Lown JW. Reaction of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) with guanosine: evidence for a new mechanism of DNA modification. Biochemical and Biophysical Research Communications. 139: 31-6. PMID 3767959 DOI: 10.1016/S0006-291X(86)80075-4  0.39
1986 Otter A, Hanstock CC, Kotovych G, Rayner B, Vasseur JJ, Imbach JL, Lown JW. Molecular recognition of DNA binding agents: high-field 1H and 31P one- and two-dimensional NMR studies on the 1:1 intercalation complexes of mitoxantrone with selected oligodeoxyribonucleotides. Basic Life Sciences. 38: 211-8. PMID 3741333 DOI: 10.1007/978-1-4615-9462-8_22  0.386
1986 Morvan F, Rayner B, Imbach JL, Chang DK, Lown JW. alpha-DNA. I. Synthesis, characterization by high field 1H-NMR, and base-pairing properties of the unnatural hexadeoxyribonucleotide alpha-[d(CpCpTpTpCpC)] with its complement beta-[d(GpGpApApGpG)]. Nucleic Acids Research. 14: 5019-35. PMID 3725590 DOI: 10.1093/Nar/14.12.5019  0.302
1986 Lown JW, Krowicki K, Bhat UG, Skorobogaty A, Ward B, Dabrowiak JC. Molecular recognition between oligopeptides and nucleic acids: Novel imidazole-containing oligopeptides related to netropsin that exhibit altered DNA sequence specificity Biochemistry. 25: 7408-7416. PMID 3026455 DOI: 10.1021/Bi00371A024  0.439
1986 Peters JH, Gordon GR, Kashiwase D, Lown JW, Yen SF, Plambeck JA. Redox activities of antitumor anthracyclines determined by microsomal oxygen consumption and assays for superoxide anion and hydroxyl radical generation. Biochemical Pharmacology. 35: 1309-23. PMID 3008758 DOI: 10.1016/0006-2952(86)90276-5  0.344
1985 Lown JW, Morgan AR, Yen SF, Wang YH, Wilson WD. Characteristics of the binding of the anticancer agents mitoxantrone and ametantrone and related structures to deoxyribonucleic acids. Biochemistry. 24: 4028-35. PMID 4052381 DOI: 10.1021/bi00336a034  0.566
1984 Lown JW, Chauhan SMS, Koganty RR, Sapse AM. Alkyldinitrogen species implicated in the carcinogenic, mutagenic, and anticancer activities of N-nitroso compounds: characterization by nitrogen-15 NMR of nitrogen-15-enriched compounds and analysis of DNA base situselectivity by ab initio calculations Journal of the American Chemical Society. 106: 6401-6408. DOI: 10.1021/Ja00333A051  0.356
1983 Lown JW, Hanstock CC, Joshua AV, Arai T, Takahashi K. Structure and conformation of saframycin R determined by high field 1H and 13C NMR and its interactions with DNA in solution. The Journal of Antibiotics. 36: 1184-94. PMID 6630077 DOI: 10.7164/Antibiotics.36.1184  0.398
1983 Lown JW. The mechanism of action of quinone antibiotics. Molecular and Cellular Biochemistry. 55: 17-40. PMID 6353197 DOI: 10.1007/Bf00229240  0.405
1982 Lown JW, Joshua AV, Lee JS. Molecular mechanisms of binding and single-strand scission of DNA by the antitumor antibiotics saframycins A and C Biochemistry. 21: 419-428. PMID 7066293 DOI: 10.1021/Bi00532A001  0.44
1982 Lown JW, Chen HH, Plambeck JA, Acton EM. Further studies on the generation of reactive oxygen species from activated anthracyclines and the relationship to cytotoxic action and cardiotoxic effects. Biochemical Pharmacology. 31: 575-81. PMID 6279110 DOI: 10.1016/0006-2952(82)90162-9  0.32
1982 Lown JW, Singh R. Mechanism of action of antitumor 3-(2-haloethyl) aryltriazenes on deoxyribonucleic acid. Biochemical Pharmacology. 31: 1257-66. PMID 6178413 DOI: 10.1016/0006-2952(82)90013-2  0.424
1982 Lown JW, Joshua AV. Bleomycin models. Haemin–acridines which bind to DNA and cause oxygen-dependent scission Journal of the Chemical Society, Chemical Communications. 1298-1300. DOI: 10.1039/C39820001298  0.392
1981 Lown JW, Chauhan SMS. Mechanism of action of (2-haloethyl)nitrosoureas on DNA. Isolation and reactions of postulated 2-(alkylimino)-3-nitrosooxazolidine intermediates in the decomposition of 1,3-bis(2-chloroethyl)-, 1-(2-chloroethyl)-3-cyclohexyl-, and 1-(2-chloroethyl)-3-(4'-trans-methylcyclohexyl)-1-nitrosourea. Journal of Medicinal Chemistry. 24: 270-279. PMID 7265113 DOI: 10.1021/Jm00135A007  0.378
1981 Lown JW, Joshua AV, Chen H. Studies related to antitumor antibiotics. Part XXIV. High field 1H nmr analysis and conformations of saframycins A and C Canadian Journal of Chemistry. 59: 2945-2952. DOI: 10.1139/V81-427  0.361
1981 Lown JW, Singh R. Synthesis of 3(2-haloethyl)aryltriazenes and study of their reactions in aqueous solution Canadian Journal of Chemistry. 59: 1347-1356. DOI: 10.1139/V81-198  0.318
1981 Lown JW, Chen H. Evidence for the generation of free hydroxyl radicals from certain quinone antitumor antibiotics upon reductive activation in solution Canadian Journal of Chemistry. 59: 390-395. DOI: 10.1139/V81-060  0.302
1981 Lown JW, Chauhan SMS. Synthesis and reactions of deuterated 2-(alkylimino)-3-nitrosooxazolidines, 3-alkyl-1-(2-hydroxyethyl)-1-nitrosoureas, and related compounds as possible intermediates in the aqueous decomposition of 3-alkyl-1-(2-chloroethyl)-1-nitrosoureas The Journal of Organic Chemistry. 46: 2479-2489. DOI: 10.1021/Jo00325A011  0.345
1980 Lown JW, Joshua AV, McLaughlin LW. Noval antitumor nitrosoureas and related compounds and their reactions with DNA. Journal of Medicinal Chemistry. 23: 798-805. PMID 7401107  0.571
1980 Lown JW, Chen HH. Studies on the effects of the antitumor agent camptothecin and derivatives on deoxyribonucleic acid. Mechanism of the scission of deoxyribonucleic acid by photoactivated camptothecin. Biochemical Pharmacology. 29: 905-15. PMID 7387708 DOI: 10.1016/0006-2952(80)90221-X  0.464
1980 Lown JW, Joshua AV. Interactions of the glycopeptide antitumor antibiotics bleomycin and tallysomycin with deoxyribonucleic acid in vitro. Biochemical Pharmacology. 29: 521-32. PMID 6154464 DOI: 10.1016/0006-2952(80)90372-X  0.427
1980 Lown JW, Chen HH, Plambeck JA, Acton EM. Diminished superoxide anion generation by reduced 5-iminodaunorubicin relative to daunorubicin and the relationship to cardiotoxicity of the anthracycline antitumor agents. Biochemical Pharmacology. 28: 2563-8. PMID 229856 DOI: 10.1016/0006-2952(79)90027-3  0.366
1980 LOWN JW, GUNN BC, MAJUMDAR KC, MCGORAN E. ChemInform Abstract: SYNTHESIS OF POTENTIAL DNA BISINTERCALATIVE AGENTS OF THE PHENANTHRIDINIUM CLASS Chemischer Informationsdienst. 11. DOI: 10.1002/chin.198003283  0.564
1979 Lown JW, McLaughlin LW. Mechanism of action of 2-haloethylnitrosoureas on deoxyribonucleic acid. Nature of the chemical reactions with deoxyribonucleic acid. Biochemical Pharmacology. 28: 2123-8. PMID 496996 DOI: 10.1016/0006-2952(79)90193-X  0.646
1979 Lown JW, McLaughlin LW. Nitrosourea-induced DNA single-strand breaks. Biochemical Pharmacology. 28: 1631-8. PMID 383080 DOI: 10.1016/0006-2952(79)90176-X  0.608
1979 Lown JW, Joshua AV. Molecular mechanism of binding of pyrrolo(1,4)benzodiazepine antitumour agents to deoxyribonucleic acid--anthramycin and tomaymycin. Biochemical Pharmacology. 28: 2017-26. PMID 224883 DOI: 10.1016/0006-2952(79)90218-1  0.455
1979 Lown JW, Sim SK, Chen HH. Hydroxyl radical production by free and DNA-bound aminoquinone antibiotics and its role in DNA degradation. Electron spin resonance detection of hydroxyl radicals by spin trapping. Canadian Journal of Biochemistry. 56: 1042-7. PMID 216472 DOI: 10.1139/O78-164  0.35
1979 Lown JW, McLaughlin LW, Plambeck JA. Mechanism of action of 2-haloethylnitrosoureas on deoxyribonucleic acid. Nature of the intermediates from nitrosourea decomposition. Biochemical Pharmacology. 28: 2115-21. PMID 40555 DOI: 10.1016/0006-2952(79)90192-8  0.54
1979 Lown JW, Gunn BC, Majumdar KC, McGoran E. Synthesis of potential DNA bisintercalative agents of the phenanthridinium class Canadian Journal of Chemistry. 57: 2305-2313. DOI: 10.1139/V79-369  0.406
1979 Lown J, Chen H, Sim S, Plambeck JA. Reactions of the antitumor agent carminic acid and derivatives with DNA Bioorganic Chemistry. 8: 17-24. DOI: 10.1016/0045-2068(79)90032-4  0.426
1978 Sim SK, Lown JW. The mechanism of the neocarzinostatin-induced cleavage of DNA. Biochemical and Biophysical Research Communications. 81: 99-105. PMID 148890 DOI: 10.1016/0006-291X(78)91635-2  0.414
1978 Lown JW, Weir GL. Studies related to antitumor antibiotics. Part XIII. Reactivity of 2- and 3-indolylcarbinyl compounds as models for mitosane action Canadian Journal of Chemistry. 56: 249-257. DOI: 10.1139/V78-040  0.41
1978 Lown JW, Weir G. Studies related to antitumor antibiotics. Part XIV. Reactions of mitomycin B with DNA Canadian Journal of Biochemistry. 56: 296-304. DOI: 10.1139/O78-046  0.424
1978 Lown J, McLaughlin LW, Chang Y. Mechanism of action of 2-haloethylnitrosoureas on DNA and its relation to their antileukemic properties Bioorganic Chemistry. 7: 97-110. DOI: 10.1016/0045-2068(78)90021-4  0.627
1978 Lown JW, Sim SK. Photoreaction of psoralen and other furocoumarins with nucleic acids Bioorganic Chemistry. 7: 85-95. DOI: 10.1016/0045-2068(78)90020-2  0.432
1977 Lown JW, Sim SK, Majumdar KC, Chang RY. Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents. Biochemical and Biophysical Research Communications. 76: 705-10. PMID 197922 DOI: 10.1016/0006-291X(77)91557-1  0.442
1977 Lown JW, Sim SK. The mechanism of the bleomycin-induced cleavage of DNA. Biochemical and Biophysical Research Communications. 77: 1150-7. PMID 71149 DOI: 10.1016/S0006-291X(77)80099-5  0.392
1977 Lown JW, Majumdar KC. Studies related to antitumor antibiotics. Part IX. Reactions of carzinophillin with DNA assayed by ethidium fluorescence. Canadian Journal of Biochemistry. 55: 630-5. PMID 18267 DOI: 10.1139/O77-091  0.42
1977 Lown JW, Joshua AV. Electrophilic additions of iodonium nitrate to unsaturated substrates Canadian Journal of Chemistry. 55: 122-130. DOI: 10.1139/V77-022  0.308
1977 Lown J, Majumdar KC, Meyers AI, Hecht A. Studies related to antitumor antibiotics Bioorganic Chemistry. 6: 453-463. DOI: 10.1016/0045-2068(77)90044-X  0.645
1976 Lown JW, Sim SK. Studies related to antitumor antibiotics. Part VIII. Cleavage of DNA by streptonigrin analogues and the relationship to antineoplastic activity. Canadian Journal of Biochemistry. 54: 446-52. PMID 1276971 DOI: 10.1139/O76-064  0.416
1976 Cone R, Hasan SK, Lown JW, Morgan AR. The mechanism of the degradation of DNA by streptonigrin. Canadian Journal of Biochemistry. 54: 219-23. PMID 1260505 DOI: 10.1139/o76-034  0.545
1976 Lown JW, Begleiter A, Johnson D, Morgan AR. Studies related to antitumor antibiotics. Part V. Reactions of mitomycin C with DNA examined by ethidium fluorescence assay. Canadian Journal of Biochemistry. 54: 110-9. PMID 4201 DOI: 10.1139/O76-018  0.555
1976 Lown JW, Sim S. Studies related to antitumor antibiotics. Part VII. Synthesis of streptonigrin analogues and their single strand scission of DNA Canadian Journal of Chemistry. 54: 2563-2572. DOI: 10.1139/V76-363  0.401
1976 AKHTAR MH, BEGLEITER A, JOHNSON D, LOWN JW, MCLAUGHLIN L, SIM S. ChemInform Abstract: ANTITUMOR ANTIBIOTICS. VI. CORRELATION OF COVALENT CROSS-LINKING OF DNA BY BIFUNCTIONAL AZIRIDINOQUINONES WITH THEIR ANTINEOPLASTIC ACTIVITY Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/Chin.197612204  0.605
1975 Akhtar MH, Begleiter A, Johnson D, Lown JW, McLaughlin L, Sim S. Studies Related to Antitumor Antibiotics. Part VI. Correlation of Covalent Cross-linking of DNA by Bifunctional Aziridinoquinones with their Antineoplastic Activity Canadian Journal of Chemistry. 53: 2891-2905. DOI: 10.1139/V75-409  0.635
1975 Landberg BE, Lown JW. Application of functionalised 1,3-dipoles to the synthesis of fused heterocycles Journal of the Chemical Society-Perkin Transactions 1. 6: 1326-1333. DOI: 10.1039/P19750001326  0.316
1975 Lown JW, Landberg BE. Further Synthetic Applications of Functionalized 1,3-Dipoles Canadian Journal of Chemistry. 53: 3782-3790. DOI: 10.1002/Chin.197620236  0.311
1975 Lown JW, Itoh T. Studies Related to Antitumor Antibiotics. Part III. Syntheses of 1,2,3,4,5,6-Hexahydro-2,3-benzazocin-5-ones as Possible Intermediates in the Biosynthesis of Mitomycins Canadian Journal of Chemistry. 53: 960-969. DOI: 10.1002/Chin.197526301  0.334
1974 Lown JW, Begleiter A. Studies Relating to Aziridine Antitumor Antibiotics. Part II. 13C and 1H Nuclear Magnetic Resonance Spectra of Mitomycin C and Structurally Related Streptonigrin Canadian Journal of Chemistry. 52: 2331-2336. DOI: 10.1139/V74-336  0.313
1973 Lown JW, Joshua AV. Stereochemistry and regiochemistry of the addition of lodonium nitrate to alkenes Journal of the Chemical Society-Perkin Transactions 1. 5: 2680-2687. DOI: 10.1039/P19730002680  0.335
1963 Lemieux RU, Lown JW. THE β-D -CONFIGURATION OF THE RIBOSYL NICOTINAMIDE PORTION OF DIPHOSPHOPYRIDINE NUCLEOTIDE Canadian Journal of Chemistry. 41: 889-897. DOI: 10.1139/v63-127  0.457
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