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Alexander S.S. Dömling - Publications

Affiliations: 
University of Groningen, Groningen, Netherlands 
Area:
Drug Design
Website:
http://hoogleraren.ub.rug.nl/?page=showPerson&type=hoogleraar&hoogleraar_id=2262
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Year Citation  Score
2024 Li J, Zheng Q, Dömling A. Exploring Phthalimide as the Acid Component in the Passerini Reaction. Organic Letters. PMID 38227542 DOI: 10.1021/acs.orglett.3c03962  0.492
2023 Patil P, Zheng Q, Kurpiewsk K, Dömling A. The isocyanide S2 reaction. Nature Communications. 14: 5807. PMID 37726293 DOI: 10.1038/s41467-023-41253-2  0.446
2023 Li X, Romero MD, Tcaturian S, Kurpiewska K, Dömling A. -Edited Guanine Isosteres. The Journal of Organic Chemistry. PMID 37431831 DOI: 10.1021/acs.joc.3c00467  0.429
2023 Gao L, Shaabani S, Reyes Romero A, Xu R, Ahmadianmoghaddam M, Dömling A. 'Chemistry at the speed of sound': automated 1536-well nanoscale synthesis of 16 scaffolds in parallel. Green Chemistry : An International Journal and Green Chemistry Resource : Gc. 25: 1380-1394. PMID 36824604 DOI: 10.1039/d2gc04312b  0.388
2022 Li X, Wang Q, Zheng Q, Kurpiewska K, Kalinowska-Tluscik J, Dömling A. Access to Isoquinolin-2(1)-yl-acetamides and Isoindolin-2-yl-acetamides from a Common MCR Precursor. The Journal of Organic Chemistry. PMID 36282152 DOI: 10.1021/acs.joc.2c01905  0.447
2022 Xu R, Wang Z, Zheng Q, Patil P, Dömling A. . The Journal of Organic Chemistry. PMID 36095044 DOI: 10.1021/acs.joc.2c01561  0.456
2022 Iordanidou D, Kallitsakis MG, Tzani MA, Ioannou DI, Zarganes-Tzitzikas T, Neochoritis CG, Dömling A, Terzidis MA, Lykakis IN. Supported Gold Nanoparticle-Catalyzed Selective Reduction of Multifunctional, Aromatic Nitro Precursors into Amines and Synthesis of 3,4-Dihydroquinoxalin-2-Ones. Molecules (Basel, Switzerland). 27. PMID 35889270 DOI: 10.3390/molecules27144395  0.359
2022 Dömling A. Innovations and Inventions: Why Was the Ugi Reaction Discovered Only 37 Years after the Passerini Reaction? The Journal of Organic Chemistry. PMID 35881912 DOI: 10.1021/acs.joc.2c00792  0.376
2022 Zheng Q, Li X, Kurpiewska K, Dömling A. Synthesis of Tunable Fluorescent Imidazole-Fused Heterocycle Dimers. Organic Letters. PMID 35830622 DOI: 10.1021/acs.orglett.2c01642  0.309
2022 Zhang B, Kurpiewska K, Dömling A. Highly Stereoselective Ugi/Pictet-Spengler Sequence. The Journal of Organic Chemistry. 87: 7085-7096. PMID 35549475 DOI: 10.1021/acs.joc.2c00244  0.474
2021 Wang Q, Mgimpatsang KC, Li X, Dömling A. Isoquinolone-4-Carboxylic Acids by Ammonia-Ugi-4CR and Copper-Catalyzed Domino Reaction. The Journal of Organic Chemistry. PMID 34184894 DOI: 10.1021/acs.joc.1c01170  0.456
2021 Lei X, Lampiri P, Patil P, Angeli G, Neochoritis CG, Dömling A. A multicomponent tetrazolo indole synthesis. Chemical Communications (Cambridge, England). PMID 34128009 DOI: 10.1039/d1cc02384e  0.502
2021 Gao K, Shaabani S, Xu R, Zarganes-Tzitzikas T, Gao L, Ahmadianmoghaddam M, Groves MR, Dömling A. Nanoscale, automated, high throughput synthesis and screening for the accelerated discovery of protein modifiers. Rsc Medicinal Chemistry. 12: 809-818. PMID 34124680 DOI: 10.1039/d1md00087j  0.308
2021 Sutanto F, Shaabani S, Neochoritis CG, Zarganes-Tzitzikas T, Patil P, Ghonchepour E, Dömling A. Multicomponent reaction-derived covalent inhibitor space. Science Advances. 7. PMID 33536213 DOI: 10.1126/sciadv.abd9307  0.49
2020 Neochoritis CG, Zarganes-Tzitzikas T, Katsampoxaki-Hodgetts K, Dömling A. Multicomponent Reactions: "Kinderleicht". Journal of Chemical Education. 97: 3739-3745. PMID 33071311 DOI: 10.1021/acs.jchemed.0c00290  0.346
2020 Wang Q, Tuinhof J, Mgimpatsang KC, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Copper-Catalyzed Modular Assembly of Polyheterocycles. The Journal of Organic Chemistry. PMID 32615764 DOI: 10.1021/acs.joc.0c01238  0.319
2020 Vishwanatha TM, Giepmans B, Goda SK, Dömling A. Tubulysin Synthesis Featuring Stereoselective Catalysis and Highly Convergent Multicomponent Assembly. Organic Letters. 22: 5396-5400. PMID 32584589 DOI: 10.1021/acs.orglett.0c01718  0.407
2020 Li J, Di Lorenzo V, Patil P, Ruiz Moreno AJ, Kurpiewska K, Kalinowska-Tłuścik J, Velasco-Velázquez MA, Dömling A. Scaffolding-induced property modulation of chemical space. Acs Combinatorial Science. PMID 32441919 DOI: 10.1021/acscombsci.0c00072  0.411
2020 Konstantinidou M, Magari F, Sutanto F, Haupenthal J, Jumde VR, Ünver MY, Heine A, Camacho CJ, Hirsch AKH, Klebe G, Dömling A. Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach. Chemmedchem. PMID 32187447 DOI: 10.1002/Cmdc.202000024  0.301
2020 Abdelraheem EMM, Goodwin I, Shaabani S, de Haan MP, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. 'Atypical Ugi' tetrazoles. Chemical Communications (Cambridge, England). 56: 1799-1802. PMID 31950120 DOI: 10.1039/c9cc09194g  0.332
2019 Boltjes A, Dömling A. The Groebke-Blackburn-Bienaymé Reaction. European Journal of Chemistry (Print). 2019: 7007-7049. PMID 34012704 DOI: 10.1002/ejoc.201901124  0.403
2019 Neochoritis CG, Zarganes-Tzitzikas T, Novotná M, Mitríková T, Wang Z, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Isocyanide-Based Multicomponent Reactions of Free Phenylboronic Acids. European Journal of Chemistry (Print). 2019: 6132-6137. PMID 33981465 DOI: 10.1002/ejoc.201901187  0.399
2019 Rudick JG, Shaabani S, Dömling A. Editorial: Isocyanide-Based Multicomponent Reactions. Frontiers in Chemistry. 7: 918. PMID 32010668 DOI: 10.3389/Fchem.2019.00918  0.363
2019 Wang Q, Mgimpatsang KC, Konstantinidou M, Shishkina SV, Dömling A. 1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction. Organic Letters. PMID 31478379 DOI: 10.1021/acs.orglett.9b02614  0.371
2019 Kunig VBK, Ehrt C, Dömling A, Brunschweiger A. Isocyanide Multicomponent Reactions on Solid-Phase-Coupled DNA Oligonucleotides for Encoded Library Synthesis. Organic Letters. 21: 7238-7243. PMID 31464126 DOI: 10.1021/acs.orglett.9b02448  0.342
2019 Wang Q, Osipyan A, Konstantinidou M, Butera R, Mgimpatsang KC, Shishkina SV, Dömling A. Pd-catalyzed De Novo Assembly of Diversely Substituted Indole-Fused Polyheterocycles. The Journal of Organic Chemistry. PMID 31433186 DOI: 10.1021/acs.joc.9b01258  0.395
2019 Neochoritis CG, Shaabani S, Ahmadianmoghaddam M, Zarganes-Tzitzikas T, Gao L, Novotná M, Mitríková T, Romero AR, Irianti MI, Xu R, Olechno J, Ellson R, Helan V, Kossenjans M, Groves MR, et al. Rapid approach to complex boronic acids. Science Advances. 5: eaaw4607. PMID 31281893 DOI: 10.1126/sciadv.aaw4607  0.458
2019 Wang Y, Patil P, Kurpiewska K, Kalinowska-Tluscik J, Dömling A. Diverse Isoquinoline Scaffolds by Ugi/Pomeranz-Fritsch and Ugi/Schlittler-Müller Reactions. Organic Letters. PMID 31033297 DOI: 10.1021/acs.orglett.9b00778  0.488
2019 Wang Y, Shaabani S, Ahmadianmoghaddam M, Gao L, Xu R, Kurpiewska K, Kalinowska-Tluscik J, Olechno J, Ellson R, Kossenjans M, Helan V, Groves M, Dömling A. Acoustic Droplet Ejection Enabled Automated Reaction Scouting. Acs Central Science. 5: 451-457. PMID 30937372 DOI: 10.1021/acscentsci.8b00782  0.395
2019 Zarganes-Tzitzikas T, Neochoritis CG, Dömling A. Atorvastatin (Lipitor) by MCR. Acs Medicinal Chemistry Letters. 10: 389-392. PMID 30891146 DOI: 10.1021/acsmedchemlett.8b00579  0.383
2019 Neochoritis CG, Kazemi Miraki M, Abdelraheem EMM, Surmiak E, Zarganes-Tzitzikas T, Łabuzek B, Holak TA, Dömling A. Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists. Beilstein Journal of Organic Chemistry. 15: 513-520. PMID 30873235 DOI: 10.3762/bjoc.15.45  0.338
2019 Neochoritis CG, Zhao T, Dömling A. Tetrazoles via Multicomponent Reactions. Chemical Reviews. 119: 1970-2042. PMID 30707567 DOI: 10.1021/acs.chemrev.8b00564  0.367
2019 Shaabani S, Xu R, Ahmadianmoghaddam M, Gao L, Stahorsky M, Olechno J, Ellson R, Kossenjans M, Helan V, Dömling A. Automated and Accelerated Synthesis of Indole Derivatives on a Nano-Scale. Green Chemistry : An International Journal and Green Chemistry Resource : Gc. 21: 225-232. PMID 30686932 DOI: 10.1039/C8GC03039A  0.483
2018 Madhavachary R, Naveen N, Wang Y, Wang Q, Konstantinidou M, Dömling A. β-Carbolinone Analogues from the Ugi Silver Mine. European Journal of Organic Chemistry. 2018: 3139-3143. PMID 31440115 DOI: 10.1002/ejoc.201800557  0.631
2018 Abdelraheem EMM, Khaksar S, Dömling A. Concise Synthesis of Macrocycles by Multicomponent Reactions. Synthesis. 50: 1027-1038. PMID 31439965 DOI: 10.1055/s-0036-1590946  0.481
2018 Iordanidou D, Zarganes-Tzitzikas T, Neochoritis CG, Dömling A, Lykakis IN. Application of Silver Nanoparticles in the Multicomponent Reaction Domain: A Combined Catalytic Reduction Methodology to Efficiently Access Potential Hypertension or Inflammation Inhibitors. Acs Omega. 3: 16005-16013. PMID 30533584 DOI: 10.1021/acsomega.8b02749  0.404
2018 Abdelraheem EMM, Shaabani S, Dömling A. Macrocycles: MCR synthesis and applications in drug discovery. Drug Discovery Today. Technologies. 29: 11-17. PMID 30471668 DOI: 10.1016/j.ddtec.2018.06.008  0.367
2018 Shaabani S, Dömling A. The Catalytic Enantioselective Ugi Four-Component Reactions. Angewandte Chemie (International Ed. in English). 57: 16266-16268. PMID 30431219 DOI: 10.1002/anie.201811129  0.408
2018 Kurhade S, Diekstra E, Sutanto F, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Multicomponent Reaction Based Synthesis of 1-Tetrazolylimidazo[1,5- a]pyridines. Organic Letters. 20: 3871-3874. PMID 29943994 DOI: 10.1021/acs.orglett.8b01452  0.52
2018 Madhavachary R, Zarganes-Tzitzikas T, Patil P, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Synthesis of highly substituted imidazole Uracil containing molecules via Ugi-4CR and Passerini-3CR. Acs Combinatorial Science. PMID 29457887 DOI: 10.1021/acscombsci.7b00145  0.688
2018 Abdelraheem EMM, Khaksar S, Kurpiewska K, Kalinowska-Tłuścik J, Shaabani S, Dömling A. Two-Step Macrocycle Synthesis by Classical Ugi Reaction. The Journal of Organic Chemistry. 83: 1441-1447. PMID 29327924 DOI: 10.1021/acs.joc.7b02984  0.501
2017 Chandgude AL, Dömling A. Direct Amination of α-Hydroxy Amides. Asian Journal of Organic Chemistry. 6: 981-983. PMID 32864291 DOI: 10.1002/ajoc.201700277  0.401
2017 Chandgude AL, Li J, Dömling A. 2-Nitrobenzyl Isocyanide as a Universal Convertible Isocyanide. Asian Journal of Organic Chemistry. 6: 798-801. PMID 31236321 DOI: 10.1002/ajoc.201700177  0.416
2017 Chandgude AL, Narducci D, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Diastereoselective One Pot Five-Component Reaction toward 4-(Tetrazole)-1,3-Oxazinanes. Rsc Advances. 7: 49995-49998. PMID 29430295 DOI: 10.1039/C7RA07392E  0.437
2017 Patil P, Mishra B, Sheombarsing G, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Library-to-library synthesis of highly substituted α-aminomethyl tetrazoles via Ugi reaction. Acs Combinatorial Science. PMID 29215263 DOI: 10.1021/acscombsci.7b00137  0.426
2017 Abdelraheem EMM, Madhavachary R, Rossetti A, Kurpiewska K, Kalinowska-Tłuścik J, Shaabani S, Dömling A. Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings. Organic Letters. 19: 6176-6179. PMID 29083197 DOI: 10.1021/acs.orglett.7b03094  0.671
2017 Abdelraheem EMM, de Haan MP, Patil P, Kurpiewska K, Kalinowska-Tłuścik J, Shaabani S, Dömling A. Concise Synthesis of Tetrazole Macrocycle. Organic Letters. 19: 5078-5081. PMID 28901777 DOI: 10.1021/acs.orglett.7b02319  0.442
2017 Vishwanatha TM, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Cysteine Isocyanide in Multicomponent Reaction: Synthesis of Peptido-Mimetic 1,3-Azoles. The Journal of Organic Chemistry. 82: 9585-9594. PMID 28817272 DOI: 10.1021/acs.joc.7b01615  0.499
2017 Madhavachary R, Wang Q, Dömling A. With unprotected amino acids to tetrazolo peptidomimetics. Chemical Communications (Cambridge, England). PMID 28707691 DOI: 10.1039/c7cc03370b  0.683
2017 Vishwanatha TM, Bergamaschi E, Dömling A. Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics. Organic Letters. 19: 3195-3198. PMID 28581763 DOI: 10.1021/acs.orglett.7b01324  0.438
2017 Patil P, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction. Acs Combinatorial Science. 19: 343-350. PMID 28240545 DOI: 10.1021/acscombsci.7b00033  0.471
2017 Chandgude AL, Dömling A. N-Hydroxyimide Ugi Reaction toward α-Hydrazino Amides. Organic Letters. 19: 1228-1231. PMID 28220702 DOI: 10.1021/acs.orglett.7b00205  0.382
2017 Wang Y, Patil P, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Two cycles with one catch: hydrazine in Ugi 4-CR and its post-cyclizations. Acs Combinatorial Science. PMID 28181791 DOI: 10.1021/acscombsci.7b00009  0.487
2017 Patil P, Madhavachary R, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. De Novo Assembly of Highly Substituted Morpholines and Piperazines. Organic Letters. 19: 642-645. PMID 28102692 DOI: 10.1021/acs.orglett.6b03807  0.675
2016 Chandgude AL, Dömling A. Unconventional Passerini Reaction toward α-Aminoxy-amides. Organic Letters. 18: 6396-6399. PMID 27978705 DOI: 10.1021/acs.orglett.6b03293  0.421
2016 Chandgude AL, Dömling A. An Efficient Passerini Tetrazole Reaction (PT-3CR). Green Chemistry : An International Journal and Green Chemistry Resource : Gc. 18: 3718-3721. PMID 27840590 DOI: 10.1039/C6GC00910G  0.362
2016 Kroon E, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Cleavable β-Cyanoethyl Isocyanide in the Ugi Tetrazole Reaction. Organic Letters. 18: 4762-4765. PMID 27610711 DOI: 10.1021/acs.orglett.6b01826  0.419
2016 Abdelraheem EM, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Artificial Macrocycles by Ugi Reaction and Passerini Ring Closure. The Journal of Organic Chemistry. 81: 8789-8795. PMID 27598302 DOI: 10.1021/acs.joc.6b01430  0.479
2016 Boltjes A, Shrinidhi A, van de Kolk K, Herdtweck E, Dömling A. Gd-TEMDO: Design, Synthesis, and MRI Application. Chemistry (Weinheim An Der Bergstrasse, Germany). 22: 7352-6. PMID 26991633 DOI: 10.1002/chem.201600720  0.347
2016 Patil P, de Haan M, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Versatile Protecting-Group Free Tetrazolomethane Amine Synthesis by Ugi Reaction. Acs Combinatorial Science. 18: 170-5. PMID 26848739 DOI: 10.1021/acscombsci.5b00189  0.444
2015 Zarganes-Tzitzikas T, Chandgude AL, Dömling A. Multicomponent Reactions, Union of MCRs and Beyond. Chemical Record (New York, N.Y.). 15: 981-96. PMID 26455350 DOI: 10.1002/tcr.201500201  0.318
2015 Liao GP, Abdelraheem EM, Neochoritis CG, Kurpiewska K, Kalinowska-Tłuścik J, McGowan DC, Dömling A. Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids. Organic Letters. 17: 4980-3. PMID 26439710 DOI: 10.1021/acs.orglett.5b02419  0.41
2015 Neochoritis CG, Zarganes-Tzitzikas T, Stotani S, Dömling A, Herdtweck E, Khoury K, Dömling A. Leuckart-Wallach Route Toward Isocyanides and Some Applications. Acs Combinatorial Science. 17: 493-9. PMID 26226194 DOI: 10.1021/acscombsci.5b00066  0.422
2015 Neochoritis CG, Stotani S, Mishra B, Dömling A. Efficient isocyanide-less isocyanide-based multicomponent reactions. Organic Letters. 17: 2002-5. PMID 25824100 DOI: 10.1021/acs.orglett.5b00759  0.32
2014 Zarganes-Tzitzikas T, Patil P, Khoury K, Herdtweck E, Dömling A. Concise Synthesis of Tetrazole-keto-piperazines by Two Consecutive Ugi Reactions. European Journal of Organic Chemistry. 2015: 51-55. PMID 26949370 DOI: 10.1002/ejoc.201403401  0.47
2014 Patil P, Khoury K, Herdtweck E, Dömling A. MCR synthesis of a tetracyclic tetrazole scaffold. Bioorganic & Medicinal Chemistry. 23: 2699-715. PMID 25630499 DOI: 10.1016/j.bmc.2014.12.021  0.398
2014 Patil P, Khoury K, Herdtweck E, Dömling A. A universal isocyanide for diverse heterocycle syntheses. Organic Letters. 16: 5736-9. PMID 25351886 DOI: 10.1021/ol5024882  0.474
2014 Boltjes A, Liao GP, Zhao T, Herdtweck E, Dömling A. Ugi 4-CR Synthesis of γ- and δ-Lactams providing new access to diverse enzyme interactions, a PDB analysis. Medchemcomm. 5: 949-952. PMID 25013719 DOI: 10.1039/C4Md00162A  0.302
2014 Boltjes A, Huang Y, van de Velde R, Rijkee L, Wolf S, Gaugler J, Lesniak K, Guzik K, Holak TA, Dömling A. Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor. Acs Combinatorial Science. 16: 393-6. PMID 24983416 DOI: 10.1021/Co500026B  0.341
2014 Neochoritis CG, Dömling A. Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions. Organic & Biomolecular Chemistry. 12: 1649-51. PMID 24477767 DOI: 10.1039/c4ob00166d  0.451
2013 Sinha MK, Khoury K, Herdtweck E, Dömling A. Various cyclization scaffolds by a truly Ugi 4-CR. Organic & Biomolecular Chemistry. 11: 4792-6. PMID 23760036 DOI: 10.1039/c3ob40523k  0.422
2013 Sinha MK, Khoury K, Herdtweck E, Dömling A. Tricycles by a new Ugi variation and Pictet-Spengler reaction in one pot. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 8048-52. PMID 23649922 DOI: 10.1002/chem.201300962  0.373
2013 Zhao T, Boltjes A, Herdtweck E, Dömling A. Tritylamine as an ammonia surrogate in the Ugi tetrazole synthesis. Organic Letters. 15: 639-41. PMID 23331054 DOI: 10.1021/ol303348m  0.413
2012 Huang Y, Khoury K, Chanas T, Dömling A. Multicomponent synthesis of diverse 1,4-benzodiazepine scaffolds. Organic Letters. 14: 5916-9. PMID 23157402 DOI: 10.1021/Ol302837H  0.314
2012 Khoury K, Sinha MK, Nagashima T, Herdtweck E, Dömling A. Efficient assembly of iminodicarboxamides by a "truly" four-component reaction. Angewandte Chemie (International Ed. in English). 51: 10280-3. PMID 22968839 DOI: 10.1002/anie.201205366  0.333
2012 Wang W, Cao H, Wolf S, Camacho-Horvitz MS, Holak TA, Dömling A. Benzimidazole-2-one: a novel anchoring principle for antagonizing p53-Mdm2. Bioorganic & Medicinal Chemistry. 21: 3982-95. PMID 22789708 DOI: 10.1016/j.bmc.2012.06.020  0.302
2012 Wang K, Herdtweck E, Dömling A. Cyanoacetamides (IV): versatile one-pot route to 2-quinoline-3-carboxamides. Acs Combinatorial Science. 14: 316-22. PMID 22486416 DOI: 10.1021/co3000133  0.481
2012 Dömling A, Wang W, Wang K. Chemistry and biology of multicomponent reactions. Chemical Reviews. 112: 3083-135. PMID 22435608 DOI: 10.1021/cr100233r  0.373
2012 Liu H, William S, Herdtweck E, Botros S, Dömling A. MCR synthesis of praziquantel derivatives. Chemical Biology & Drug Design. 79: 470-7. PMID 22151001 DOI: 10.1111/j.1747-0285.2011.01288.x  0.402
2011 Huang Y, Dömling A. The Gewald multicomponent reaction. Molecular Diversity. 15: 3-33. PMID 20191319 DOI: 10.1007/S11030-010-9229-6  0.418
2010 Wang K, Herdtweck E, Dömling A. One-pot synthesis of 2-amino-indole-3-carboxamide and analogous. Acs Combinatorial Science. 13: 140-6. PMID 21395342 DOI: 10.1021/co100040z  0.395
2010 Wang W, Ollio S, Herdtweck E, Dömling A. Polycyclic compounds by Ugi-Pictet-Spengler sequence. The Journal of Organic Chemistry. 76: 637-44. PMID 21190371 DOI: 10.1021/jo102058s  0.458
2010 Cao H, Liu H, Dömling A. Efficient multicomponent reaction synthesis of the schistosomiasis drug praziquantel. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 12296-8. PMID 20845417 DOI: 10.1002/chem.201002046  0.368
2010 Wang K, Dömling A. Design of a versatile multicomponent reaction leading to 2-amino-5-ketoaryl pyrroles. Chemical Biology & Drug Design. 75: 277-83. PMID 20659110 DOI: 10.1111/j.1747-0285.2009.00942.x  0.497
2010 Huang Y, Dömling A. 1,4-Thienodiazepine-2,5-diones via MCR (II): scaffold hopping by Gewald and Ugi-deprotection-cyclization strategy. Chemical Biology & Drug Design. 76: 130-41. PMID 20545946 DOI: 10.1111/J.1747-0285.2010.00990.X  0.344
2010 Beck B, Srivastava S, Khoury K, Herdtweck E, Dömling A. One-pot multicomponent synthesis of two novel thiolactone scaffolds. Molecular Diversity. 14: 479-91. PMID 20407923 DOI: 10.1007/s11030-010-9249-2  0.446
2010 Wang K, Kim D, Dömling A. Cyanoacetamide MCR (III): three-component Gewald reactions revisited. Journal of Combinatorial Chemistry. 12: 111-8. PMID 19958011 DOI: 10.1021/cc9001586  0.48
2009 Wang W, Herdtweck E, Dömling A. Polycyclic indole alkaloid-type compounds by MCR. Chemical Communications (Cambridge, England). 46: 770-2. PMID 20087515 DOI: 10.1039/b917660h  0.368
2009 Liu H, Dömling A. One-pot synthesis of highly functionalized seleno amino acid derivatives. Chemical Biology & Drug Design. 74: 302-8. PMID 19703033 DOI: 10.1111/j.1747-0285.2009.00854.x  0.438
2009 Wang K, Nguyen K, Huang Y, Dömling A. Cyanoacetamide multicomponent reaction (I): Parallel synthesis of cyanoacetamides. Journal of Combinatorial Chemistry. 11: 920-7. PMID 19694451 DOI: 10.1021/Cc9000778  0.458
2009 Liu H, Dömling A. Efficient and diverse synthesis of indole derivatives. The Journal of Organic Chemistry. 74: 6895-8. PMID 19663394 DOI: 10.1021/jo900986z  0.447
2009 Wang W, Dömling A. Efficient synthesis of arrays of amino acid derived Ugi products with subsequent amidation. Journal of Combinatorial Chemistry. 11: 403-9. PMID 19425617 DOI: 10.1021/cc9000136  0.423
2008 Dömling A, Antuch W, Beck B, Schauer-Vukasinović V. Isosteric exchange of the acylsulfonamide moiety in Abbott's Bcl-XL protein interaction antagonist. Bioorganic & Medicinal Chemistry Letters. 18: 4115-7. PMID 18583128 DOI: 10.1016/j.bmcl.2008.05.096  0.389
2007 Dömling A, Achatz S, Beck B. Novel anti-tuberculosis agents from MCR libraries. Bioorganic & Medicinal Chemistry Letters. 17: 5483-6. PMID 17720495 DOI: 10.1016/j.bmcl.2007.04.066  0.349
2006 Dömling A, Beck B, Fuchs T, Yazbak A. Parallel synthesis of arrays of amino-acid-derived isocyanoamides useful as starting materials in IMCR. Journal of Combinatorial Chemistry. 8: 872-80. PMID 17096576 DOI: 10.1021/cc060068w  0.401
2006 Achatz S, Dömling A. Desosamine in multicomponent reactions. Bioorganic & Medicinal Chemistry Letters. 16: 6360-2. PMID 17070045 DOI: 10.1016/j.bmcl.2006.07.017  0.401
2006 Dömling A. Recent developments in isocyanide based multicomponent reactions in applied chemistry. Chemical Reviews. 106: 17-89. PMID 16402771 DOI: 10.1021/cr0505728  0.35
2004 Kolb J, Beck B, Almstetter M, Heck S, Herdtweck E, Dömling A. New MCRs: the first 4-component reaction leading to 2,4-disubstituted thiazoles. Molecular Diversity. 6: 297-313. PMID 15068094 DOI: 10.1023/b:modi.0000006827.35029.e4  0.409
2004 Beck B, Picard A, Herdtweck E, Dömling A. Highly substituted pyrrolidinones and pyridones by 4-CR/2-CR sequence. Organic Letters. 6: 39-42. PMID 14703345 DOI: 10.1021/ol035787n  0.458
2004 Kusebauch U, Beck B, Messer K, Herdtweck E, Dömling A. Massive parallel catalyst screening: toward asymmetric MCRs. Organic Letters. 5: 4021-4. PMID 14572239 DOI: 10.1021/ol035010u  0.374
2003 Beck B, Larbig G, Mejat B, Magnin-Lachaux M, Picard A, Herdtweck E, Dömling A. Short and diverse route toward complex natural product-like macrocycles. Organic Letters. 5: 1047-50. PMID 12659570 DOI: 10.1021/ol034077e  0.482
2002 Dömling A. Recent advances in isocyanide-based multicomponent chemistry. Current Opinion in Chemical Biology. 6: 306-13. PMID 12023110 DOI: 10.1016/s1367-5931(02)00328-9  0.426
Low-probability matches (unlikely to be authored by this person)
2016 Zhao T, Kurpiewska K, Kalinowska-Tłuścik J, Herdtweck E, Dömling A. α-Amino Acid-Isosteric α-Amino Tetrazoles. Chemistry (Weinheim An Der Bergstrasse, Germany). 22: 3009-18. PMID 26817531 DOI: 10.1002/chem.201504520  0.3
2019 Zarganes-Tzitzikas T, Clemente GS, Elsinga PH, Dömling A. MCR Scaffolds Get Hotter with F-Labeling. Molecules (Basel, Switzerland). 24. PMID 30987302 DOI: 10.3390/molecules24071327  0.294
2021 Zarganes-Tzitzikas T, Dömling A. Modern Multicomponent Reactions for better Drug Syntheses** Organic Chemistry Frontiers : An International Journal of Organic Chemistry. 1: 834-837. PMID 25147729 DOI: 10.1039/C4QO00088A  0.292
2019 Gonchepour E, Neochoritis CG, Kurpiewska K, Kalinowska-Tłuścik J, Islami MR, Dömling A. Glycoconjugates via phosphorus ylides. European Journal of Organic Chemistry. 2019: 3632-3635. PMID 32863756 DOI: 10.1002/ejoc.201900434  0.291
2012 Koes D, Khoury K, Huang Y, Wang W, Bista M, Popowicz GM, Wolf S, Holak TA, Dömling A, Camacho CJ. Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists. Plos One. 7: e32839. PMID 22427896 DOI: 10.1371/Journal.Pone.0032839  0.29
2006 Dömling A, Beck B, Baumbach W, Larbig G. Towards erythropoietin mimicking small molecules. Bioorganic & Medicinal Chemistry Letters. 17: 379-84. PMID 17084083 DOI: 10.1016/j.bmcl.2006.10.040  0.29
2010 Huang Y, Wolf S, Bista M, Meireles L, Camacho C, Holak TA, Dömling A. 1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity. Chemical Biology & Drug Design. 76: 116-29. PMID 20492448 DOI: 10.1111/J.1747-0285.2010.00989.X  0.289
2018 Abdelraheem EMM, Shaabani S, Dömling A. Artificial Macrocycles. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 29: 1136-1151. PMID 31354188 DOI: 10.1055/s-0036-1591975  0.289
2020 Butera R, Shrinidhi A, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Fourfold symmetric MCR's via the tetraisocyanide 1,3-diisocyano-2,2-bis(isocyanomethyl)propane. Chemical Communications (Cambridge, England). PMID 32785316 DOI: 10.1039/d0cc04522e  0.288
2019 van der Vlag R, Yagiz Unver M, Felicetti T, Twarda-Clapa A, Kassim F, Ermis C, Neochoritis CG, Musielak B, Labuzek B, Dömling A, Holak TA, Hirsch AKH. Optimized Inhibitors of MDM2 via an Attempted Protein-Templated Reductive Amination. Chemmedchem. PMID 31774938 DOI: 10.1002/Cmdc.201900574  0.283
2015 Abdelraheem EM, Camacho CJ, Dömling A. Focusing on shared subpockets - new developments in fragment-based drug discovery. Expert Opinion On Drug Discovery. 1-9. PMID 26296101 DOI: 10.1517/17460441.2015.1080684  0.257
2023 Patil P, Zheng Q, Kurpiewska K, Dömling A. Author Correction: The isocyanide S2 reaction. Nature Communications. 14: 6239. PMID 37803066 DOI: 10.1038/s41467-023-42066-z  0.256
2017 Estrada-Ortiz N, Neochoritis CG, Twarda-Clapa A, Musielak B, Holak TA, Dömling A. Artificial Macrocycles as Potent p53-MDM2 Inhibitors. Acs Medicinal Chemistry Letters. 8: 1025-1030. PMID 29057045 DOI: 10.1021/acsmedchemlett.7b00219  0.256
2012 Huang Y, Wolf S, Koes D, Popowicz GM, Camacho CJ, Holak TA, Dömling A. Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists. Chemmedchem. 7: 49-52. PMID 21954050 DOI: 10.1002/Cmdc.201100428  0.255
2008 Bon RS, Sprenkels NE, Koningstein MM, Schmitz RF, de Kanter FJ, Dömling A, Groen MB, Orru RV. Efficient C2 functionalisation of 2H-2-imidazolines. Organic & Biomolecular Chemistry. 6: 130-7. PMID 18075657 DOI: 10.1039/B713065A  0.255
2017 Koes DR, Dömling A, Camacho CJ. AnchorQuery: Rapid online virtual screening for small-molecule protein-protein interaction inhibitors. Protein Science : a Publication of the Protein Society. PMID 28921842 DOI: 10.1002/Pro.3303  0.248
2015 Kroon E, Schulze JO, Süß E, Camacho CJ, Biondi RM, Dömling A. Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods. Angewandte Chemie (International Ed. in English). PMID 26385475 DOI: 10.1002/Anie.201506310  0.245
2010 Czarna A, Beck B, Srivastava S, Popowicz GM, Wolf S, Huang Y, Bista M, Holak TA, Dömling A. Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists. Angewandte Chemie (International Ed. in English). 49: 5352-6. PMID 20575124 DOI: 10.1002/Anie.201001343  0.245
2011 Monfardini I, Huang JW, Beck B, Cellitti JF, Pellecchia M, Dömling A. Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder. Journal of Medicinal Chemistry. 54: 890-900. PMID 21241056 DOI: 10.1021/jm101341m  0.24
2010 Srivastava S, Beck B, Wang W, Czarna A, Holak TA, Dömling A. Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists. Journal of Combinatorial Chemistry. 11: 631-9. PMID 19548636 DOI: 10.1021/cc9000218  0.239
2023 Lotfy G, Abdel Aziz YM, Said MM, El Ashry ESH, El Tamany ESH, Abu-Serie MM, Teleb M, Dömling A, Barakat A. Corrigendum to "Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators" [Bioorg. Chem. 117 (2021) 105427]. Bioorganic Chemistry. 107013. PMID 38087753 DOI: 10.1016/j.bioorg.2023.107013  0.232
2021 Ulgheri F, Spanu P, Deligia F, Loriga G, Fuggetta MP, de Haan I, Chandgudge A, Groves M, Domling A. Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders. European Journal of Medicinal Chemistry. 229: 114002. PMID 34823899 DOI: 10.1016/j.ejmech.2021.114002  0.213
2009 Haney CM, Schneider C, Beck B, Brodsky JL, Dömling A. Identification of Hsp70 modulators through modeling of the substrate binding domain. Bioorganic & Medicinal Chemistry Letters. 19: 3828-31. PMID 19435667 DOI: 10.1016/J.Bmcl.2009.04.062  0.21
2023 Gao L, Shaabani S, Reyes Romero A, Xu R, Ahmadianmoghaddam M, Dömling A. Correction: 'Chemistry at the speed of sound': automated 1536-well nanoscale synthesis of 16 scaffolds in parallel. Green Chemistry : An International Journal and Green Chemistry Resource : Gc. 25: 4138. PMID 37223212 DOI: 10.1039/d3gc90037a  0.209
2021 Aziz YMA, Lotfy G, Said MM, El Ashry ESH, El Tamany ESH, Soliman SM, Abu-Serie MM, Teleb M, Yousuf S, Dömling A, Domingo LR, Barakat A. Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation. Frontiers in Chemistry. 9: 735236. PMID 34970530 DOI: 10.3389/fchem.2021.735236  0.208
2022 Alipour Najmi A, Jafariyeh-Yazdi E, Hadian M, Hermans J, Bischoff R, Yue J, Dömling A, Wittstock A, Permentier HP. Nanoporous Gold Catalyst for the Oxidative N-Dealkylation of Drug Molecules: A Method for Synthesis of N-Dealkylated Metabolites. Chemmedchem. e202200040. PMID 35303400 DOI: 10.1002/cmdc.202200040  0.205
2016 Surmiak E, Neochoritis CG, Musielak B, Twarda-Clapa A, Kurpiewska K, Dubin G, Camacho C, Holak TA, Dömling A. Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction. European Journal of Medicinal Chemistry. 126: 384-407. PMID 27907876 DOI: 10.1016/J.Ejmech.2016.11.029  0.204
2015 Neochoritis CG, Wang K, Estrada-Ortiz N, Herdtweck E, Kubica K, Twarda A, Zak KM, Holak TA, Dömling A. 2,3'-Bis(1'H-indole) heterocycles: New p53/MDM2/MDMX antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 26584879 DOI: 10.1016/j.bmcl.2015.11.019  0.201
2015 Eleftheriadis N, Neochoritis CG, Leus NG, van der Wouden PE, Dömling A, Dekker FJ. Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties. Journal of Medicinal Chemistry. 58: 7850-62. PMID 26331552 DOI: 10.1021/acs.jmedchem.5b01121  0.2
2018 Neochoritis CG, Ghonchepour E, Miraki MK, Zarganes-Tzitzikas T, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A. Structure and Reactivity of Glycosyl Isocyanides. European Journal of Organic Chemistry. 2019: 50-55. PMID 33981183 DOI: 10.1002/ejoc.201801588  0.195
2019 S Clemente G, Zarganes-Tzitzikas T, Dömling A, H Elsinga P. Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin. Molecules (Basel, Switzerland). 24. PMID 31756986 DOI: 10.3390/molecules24234210  0.193
2021 Ruiz-Moreno AJ, Dömling A, Velasco-Velázquez MA. Reverse Docking for the Identification of Molecular Targets of Anticancer Compounds. Methods in Molecular Biology (Clifton, N.J.). 2174: 31-43. PMID 32813243 DOI: 10.1007/978-1-0716-0759-6_4  0.191
2023 Wang Z, Shaabani S, Gao X, Ng YLD, Sapozhnikova V, Mertins P, Krönke J, Dömling A. Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery. Nature Communications. 14: 8437. PMID 38114468 DOI: 10.1038/s41467-023-43614-3  0.182
2006 Antuch W, Menon S, Chen QZ, Lu Y, Sakamuri S, Beck B, Schauer-Vukasinović V, Agarwal S, Hess S, Dömling A. Design and modular parallel synthesis of a MCR derived alpha-helix mimetic protein-protein interaction inhibitor scaffold. Bioorganic & Medicinal Chemistry Letters. 16: 1740-3. PMID 16427279 DOI: 10.1016/j.bmcl.2005.11.102  0.182
2014 Huang Y, Wolf S, Beck B, Köhler LM, Khoury K, Popowicz GM, Goda SK, Subklewe M, Twarda A, Holak TA, Dömling A. Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. Acs Chemical Biology. 9: 802-11. PMID 24405416 DOI: 10.1021/Cb400728E  0.181
2016 Fuggetta MP, De Mico A, Cottarelli A, Morelli F, Zonfrillo M, Ulgheri F, Peluso P, Mannu A, Deligia F, Marchetti M, Roviello GN, Reyes Romero A, Dömling A, Spanu P. Synthesis and Enantiomeric Separation of a Novel Spiroketal derivative: A Potent Human Telomerase Inhibitor with High In Vitro Anticancer Activity. Journal of Medicinal Chemistry. PMID 27592503 DOI: 10.1021/acs.jmedchem.6b01046  0.175
2019 Della Volpe S, Nasti R, Queirolo M, Unver MY, Jumde VK, Dömling A, Vasile F, Potenza D, Ambrosio FA, Costa G, Alcaro S, Zucal C, Provenzani A, Di Giacomo M, Rossi D, et al. Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies. Acs Medicinal Chemistry Letters. 10: 615-620. PMID 30996806 DOI: 10.1021/Acsmedchemlett.8B00600  0.173
2017 Guo H, Eleftheriadis N, Rohr-Udilova N, Dömling A, Dekker FJ. Photoactivation provides a mechanistic explanation for pan-assay interference behaviour of 2-aminopyrroles in lipoxygenase inhibition. European Journal of Medicinal Chemistry. 139: 633-643. PMID 28843180 DOI: 10.1016/j.ejmech.2017.07.047  0.173
2021 Lotfy G, Abdel Aziz YM, Said MM, El Ashry ESH, El Tamany ESH, Abu-Serie MM, Teleb M, Dömling A, Barakat A. Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators. Bioorganic Chemistry. 117: 105427. PMID 34794098 DOI: 10.1016/j.bioorg.2021.105427  0.173
2020 Bosch S, Lunev S, Batista FA, Linzke M, Kronenberger T, Dömling A, Groves MR, Wrenger C. Molecular target validation of Aspartate Transcarbamoylase from Plasmodium falciparum by Torin 2. Acs Infectious Diseases. PMID 32129597 DOI: 10.1021/acsinfecdis.9b00411  0.172
2015 Estrada-Ortiz N, Neochoritis CG, Dömling A. How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures. Chemmedchem. 11: 757-72. PMID 26676832 DOI: 10.1002/cmdc.201500487  0.171
2021 Dömling A, Li X. TNF-α: the shape of small molecules to come? Drug Discovery Today. PMID 34229081 DOI: 10.1016/j.drudis.2021.06.018  0.17
2017 Kok T, Wapenaar H, Wang K, Neochoritis CG, Zarganes-Tzitzikas T, Proietti G, Eleftheriadis N, Kurpiewska K, Kalinowska-Tłuścik J, Cool RH, Poelarends GJ, Dömling A, Dekker FJ. Discovery of chromenes as inhibitors of macrophage migration inhibitory factor. Bioorganic & Medicinal Chemistry. PMID 29428527 DOI: 10.1016/j.bmc.2017.12.032  0.17
2020 Wang Q, Osipyan A, Konstantinidou M, Butera R, Mgimpatsang KC, Shishkina SV, Dömling A. Correction to Pd-Catalyzed de Novo Assembly of Diversely Substituted Indole-Fused Polyheterocycles. The Journal of Organic Chemistry. PMID 32519856 DOI: 10.1021/acs.joc.0c01202  0.169
2013 Bista M, Wolf S, Khoury K, Kowalska K, Huang Y, Wrona E, Arciniega M, Popowicz GM, Holak TA, Dömling A. Transient protein states in designing inhibitors of the MDM2-p53 interaction. Structure (London, England : 1993). 21: 2143-51. PMID 24207125 DOI: 10.1016/J.Str.2013.09.006  0.166
2021 Ruiz-Moreno AJ, Reyes-Romero A, Dömling A, Velasco-Velázquez MA. In Silico Design and Selection of New Tetrahydroisoquinoline-Based CD44 Antagonist Candidates. Molecules (Basel, Switzerland). 26. PMID 33810348 DOI: 10.3390/molecules26071877  0.166
2016 Eleftheriadis N, Poelman H, Leus NG, Honrath B, Neochoritis CG, Dolga A, Dömling A, Dekker FJ. Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties. European Journal of Medicinal Chemistry. PMID 27477687 DOI: 10.1016/j.ejmech.2016.07.010  0.166
2020 Reyes Romero A, Ruiz-Moreno AJ, Groves MR, Velasco-Velázquez M, Dömling A. Benchmark of Generic Shapes for Macrocycles. Journal of Chemical Information and Modeling. 60: 6298-6313. PMID 33270455 DOI: 10.1021/acs.jcim.0c01038  0.165
2010 Popowicz GM, Czarna A, Wolf S, Wang K, Wang W, Dömling A, Holak TA. Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell Cycle (Georgetown, Tex.). 9: 1104-11. PMID 20237429 DOI: 10.4161/cc.9.6.10956  0.164
2019 Skalniak L, Twarda-Clapa A, Neochoritis CG, Surmiak E, Machula M, Wisniewska A, Labuzek B, Ali AM, Krzanik S, Dubin G, Groves M, Dömling A, Holak TA. A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53 osteosarcoma cells. The Febs Journal. PMID 30715803 DOI: 10.1111/febs.14774  0.157
2006 Dömling A, Beck B, Eichelberger U, Sakamuri S, Menon S, Chen QZ, Lu Y, Wessjohann LA. Total synthesis of tubulysin U and V. Angewandte Chemie (International Ed. in English). 45: 7235-9. PMID 17013971 DOI: 10.1002/Anie.200601259  0.154
2024 Chatziorfanou E, Romero AR, Chouchane L, Dömling A. Crystal Clear: Decoding Isocyanide Intermolecular Interactions through Crystallography. The Journal of Organic Chemistry. 89: 957-974. PMID 38175810 DOI: 10.1021/acs.joc.3c02038  0.153
2005 Yehia NA, Antuch W, Beck B, Hess S, Schauer-Vukasinović V, Almstetter M, Furer P, Herdtweck E, Dömling A. Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy. Bioorganic & Medicinal Chemistry Letters. 14: 3121-5. PMID 15149657 DOI: 10.1016/j.bmcl.2004.04.026  0.146
2017 Twarda-Clapa A, Krzanik S, Kubica K, Guzik K, Labuzek B, Neochoritis CG, Khoury K, Kowalska K, Czub M, Dubin G, Dömling A, Skalniak L, Holak TA. 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. Journal of Medicinal Chemistry. PMID 28482147 DOI: 10.1021/acs.jmedchem.7b00104  0.145
2010 Meireles LM, Dömling AS, Camacho CJ. ANCHOR: a web server and database for analysis of protein-protein interaction binding pockets for drug discovery. Nucleic Acids Research. 38: W407-11. PMID 20525787 DOI: 10.1093/Nar/Gkq502  0.143
2024 Zhang Y, Shaabani S, Vowinkel K, Trombetta-Lima M, Sabogal-Guáqueta AM, Chen T, Hoekstra J, Lembeck J, Schmidt M, Decher N, Dömling A, Dolga AM. Novel SK channel positive modulators prevent ferroptosis and excitotoxicity in neuronal cells. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 171: 116163. PMID 38242037 DOI: 10.1016/j.biopha.2024.116163  0.139
2022 Vogel JGT, Wibowo JP, Fan H, Setroikromo R, Wang K, Dömling A, Dekker FJ, Quax WJ. Discovery of chromene compounds as inhibitors of PvdQ acylase of Pseudomonas aeruginosa. Microbes and Infection. 105017. PMID 35709935 DOI: 10.1016/j.micinf.2022.105017  0.137
2013 Zych C, Domling A, Ayyavoo V. Development of a robust cell-based high-throughput screening assay to identify targets of HIV-1 viral protein R dimerization. Drug Design, Development and Therapy. 7: 403-12. PMID 23737660 DOI: 10.2147/Dddt.S44139  0.135
2016 Surmiak E, Twarda-Clapa A, Zak KM, Musielak B, Tomala MD, Kubica K, Grudnik P, Madej M, Jablonski M, Potempa J, Kalinowska-Tluscik J, Dömling A, Dubin G, Holak TA. A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction. Acs Chemical Biology. 11: 3310-3318. PMID 27709883 DOI: 10.1021/acschembio.6b00596  0.133
2021 Clemente GS, Antunes IF, Kurhade S, van den Berg MPM, Sijbesma JWA, van Waarde A, Buijsman RC, Willemsen-Seegers N, Gosens R, Meurs H, Dömling A, Elsinga PH. Mapping Arginase Expression with F-Fluorinated Late-Generation Arginase Inhibitors Derived from Quaternary α-Amino Acids. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 62: 1163-1170. PMID 33712529 DOI: 10.2967/jnumed.120.255968  0.132
2023 Ważyńska MA, Butera R, Requesens M, Plat A, Zarganes-Tzitzikas T, Neochoritis CG, Plewka J, Skalniak L, Kocik-Krol J, Musielak B, Magiera-Mularz K, Rodriguez I, Blok SN, de Bruyn M, Nijman HW, et al. Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors. Journal of Medicinal Chemistry. PMID 37450644 DOI: 10.1021/acs.jmedchem.3c00254  0.132
2019 Konstantinidou M, Li J, Zhang B, Wang Z, Shaabani S, Ter Brake F, Essa K, Dömling A. PROTACs- a game-changing technology. Expert Opinion On Drug Discovery. 1-14. PMID 31538491 DOI: 10.1080/17460441.2019.1659242  0.13
2019 Al-Qahtani AD, Bashraheel SS, Rashidi FB, O'Connor CD, Romero AR, Domling A, Goda SK. Production of "biobetter" variants of glucarpidase with enhanced enzyme activity. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 112: 108725. PMID 30970523 DOI: 10.1016/j.biopha.2019.108725  0.127
2021 Sadremomtaz A, Al-Dahmani ZM, Ruiz-Moreno AJ, Monti A, Wang C, Azad T, Bell JC, Doti N, Velasco-Velázquez MA, de Jong D, de Jonge J, Smit J, Dömling A, van Goor H, Groves MR. Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein. Journal of Medicinal Chemistry. PMID 34328726 DOI: 10.1021/acs.jmedchem.1c00477  0.124
2019 Neochoritis CG, Atmaj J, Twarda-Clapa A, Surmiak E, Skalniak L, Köhler LM, Muszak D, Kurpiewska K, Kalinowska-Tłuścik J, Beck B, Holak TA, Dömling A. Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction. European Journal of Medicinal Chemistry. 182: 111588. PMID 31421630 DOI: 10.1016/j.ejmech.2019.111588  0.122
2011 Popowicz GM, Dömling A, Holak TA. The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious. Angewandte Chemie (International Ed. in English). 50: 2680-8. PMID 21341346 DOI: 10.1002/anie.201003863  0.121
2020 Sutanto F, Konstantinidou M, Dömling A. Covalent inhibitors: a rational approach to drug discovery. Rsc Medicinal Chemistry. 11: 876-884. PMID 33479682 DOI: 10.1039/d0md00154f  0.119
2021 Jones PS, Boucharens S, McElroy SP, Morrison A, Honarnejad S, van Boeckel S, van den Hurk H, Basting D, Hüser J, Jaroch S, Ottow E, Benningshof J, Folmer RHA, Leemhuis F, Kramer-Verhulst PM, et al. IMI European Lead Factory - democratizing access to high-throughput screening. Nature Reviews. Drug Discovery. PMID 34907316 DOI: 10.1038/d41573-021-00196-3  0.117
2023 Barakat A, Alshahrani S, Al-Majid AM, Alamary AS, Haukka M, Abu-Serie MM, Dömling A, Mazyed EA, Badria FA, El-Senduny FF. Corrigendum to "Novel spirooxindole based benzimidazole scaffold: In vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinofvma" [Bioorg. Chem. 129 (2022) 106124]. Bioorganic Chemistry. 107012. PMID 38071087 DOI: 10.1016/j.bioorg.2023.107012  0.117
2008 Dömling A. Small molecular weight protein-protein interaction antagonists: an insurmountable challenge? Current Opinion in Chemical Biology. 12: 281-91. PMID 18501203 DOI: 10.1016/j.cbpa.2008.04.603  0.116
2009 Bista M, Kowalska K, Janczyk W, Dömling A, Holak TA. Robust NMR screening for lead compounds using tryptophan-containing proteins. Journal of the American Chemical Society. 131: 7500-1. PMID 19422216 DOI: 10.1021/ja901863h  0.115
2020 Dömling A, Gao L. Chemistry and Biology of SARS-CoV-2. Chem. 6: 1283-1295. PMID 32529116 DOI: 10.1016/j.chempr.2020.04.023  0.113
2015 Christner SM, Clausen DM, Beumer JH, Parise RA, Guo J, Huang Y, Dömling AS, Eiseman JL. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of pyrazole-based small molecule inhibitors of Mdm2/4-p53 interaction. Cancer Chemotherapy and Pharmacology. PMID 26050209 DOI: 10.1007/S00280-015-2791-Y  0.112
2021 Khoury K, Popowicz GM, Holak TA, Dömling A. The p53-MDM2/MDMX axis - A chemotype perspective. Medchemcomm. 2: 246-260. PMID 24466404 DOI: 10.1039/C0MD00248H  0.111
2006 Kaur G, Hollingshead M, Holbeck S, Schauer-Vukasinović V, Camalier RF, Dömling A, Agarwal S. Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product. The Biochemical Journal. 396: 235-42. PMID 16489930 DOI: 10.1042/BJ20051735  0.109
2019 Bashraheel SS, AlQahtani AD, Rashidi FB, Al-Sulaiti H, Domling A, Orie NN, Goda SK. Studies on vascular response to full superantigens and superantigen derived peptides: Possible production of novel superantigen variants with less vasodilation effect for tolerable cancer immunotherapy. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 115: 108905. PMID 31060004 DOI: 10.1016/j.biopha.2019.108905  0.103
2021 Butera R, Ważyńska M, Magiera-Mularz K, Plewka J, Musielak B, Surmiak E, Sala D, Kitel R, de Bruyn M, Nijman HW, Elsinga PH, Holak TA, Dömling A. Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists. Acs Medicinal Chemistry Letters. 12: 768-773. PMID 34055224 DOI: 10.1021/acsmedchemlett.1c00033  0.102
2021 Muszak D, Surmiak E, Plewka J, Magiera-Mularz K, Kocik-Krol J, Musielak B, Sala D, Kitel R, Stec M, Weglarczyk K, Siedlar M, Dömling A, Skalniak L, Holak TA. Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction. Journal of Medicinal Chemistry. 64: 11614-11636. PMID 34313116 DOI: 10.1021/acs.jmedchem.1c00957  0.102
2023 Almuraikhy S, Anwardeen N, Doudin A, Sellami M, Domling A, Agouni A, Althani AA, Elrayess MA. Antioxidative Stress Metabolic Pathways in Moderately Active Individuals. Metabolites. 13. PMID 37755253 DOI: 10.3390/metabo13090973  0.101
2022 Reyes Romero A, Kubica K, Kitel R, Rodríguez I, Magiera-Mularz K, Dömling A, Holak TA, Surmiak E. Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein. Molecules (Basel, Switzerland). 27. PMID 36500376 DOI: 10.3390/molecules27238282  0.098
2021 Al-Muraikhy S, Sellami M, Domling AS, Rizwana N, Agouni A, Al-Khelaifi F, Donati F, Botre F, Diboun I, Elrayess MA. Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players. Frontiers in Molecular Biosciences. 8: 727144. PMID 34977149 DOI: 10.3389/fmolb.2021.727144  0.098
2018 AlQahtani AD, Al-Mansoori L, Bashraheel SS, Rashidi FB, Al-Yafei A, Elsinga P, Domling A, Goda SK. Production of "biobetter" glucarpidase variants to improve drug detoxification and antibody directed enzyme prodrug therapy for cancer treatment. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 127: 79-91. PMID 30343151 DOI: 10.1016/j.ejps.2018.10.014  0.097
2022 Barakat A, Alshahrani S, Mohammed Al-Majid A, Saleh Alamary A, Haukka M, Abu-Serie MM, Dömling A, Mazyed EA, Badria FA, El-Senduny FF. Novel spirooxindole based benzimidazole scaffold: In vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinoma. Bioorganic Chemistry. 129: 106124. PMID 36174446 DOI: 10.1016/j.bioorg.2022.106124  0.097
2020 Clemente GS, Rickmeier J, Antunes IF, Zarganes-Tzitzikas T, Dömling A, Ritter T, Elsinga PH. [F]Atorvastatin: synthesis of a potential molecular imaging tool for the assessment of statin-related mechanisms of action. Ejnmmi Research. 10: 34. PMID 32296962 DOI: 10.1186/S13550-020-00622-4  0.096
2019 Ali AM, Atmaj J, Van Oosterwijk N, Groves MR, Dömling A. Stapled Peptides Inhibitors: A New Window for Target Drug Discovery. Computational and Structural Biotechnology Journal. 17: 263-281. PMID 30867891 DOI: 10.1016/j.csbj.2019.01.012  0.093
2019 AlQahtani AD, O'Connor D, Domling A, Goda SK. Strategies for the production of long-acting therapeutics and efficient drug delivery for cancer treatment. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 113: 108750. PMID 30849643 DOI: 10.1016/j.biopha.2019.108750  0.091
2020 S Clemente G, van Waarde A, F Antunes I, Dömling A, H Elsinga P. Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective. International Journal of Molecular Sciences. 21. PMID 32722521 DOI: 10.3390/ijms21155291  0.085
2018 Rashidi FB, AlQhatani AD, Bashraheel SS, Shaabani S, Groves MR, Dömling A, Goda SK. Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment. Plos One. 13: e0196254. PMID 29698433 DOI: 10.1371/journal.pone.0196254  0.084
2021 Reyes Romero A, Ruiz-Moreno AJ, Groves MR, Velasco-Velázquez M, Dömling A. Correction to "Benchmark of Generic Shapes for Macrocycles". Journal of Chemical Information and Modeling. 61: 3158. PMID 34032444 DOI: 10.1021/acs.jcim.1c00522  0.083
2017 Lunev S, Semmelink MF, Xian JL, Ma KY, Leenders AJ, Dömling AS, Shtutman M, Groves MR. Crystal structure of truncated human coatomer protein complex subunit ζ1 (Copζ1). Acta Crystallographica. Section F, Structural Biology Communications. 73: 1-8. PMID 28045387 DOI: 10.1107/S2053230X16018896  0.083
2015 Wu S, Huang J, Gazzarrini S, He S, Chen L, Li J, Xing L, Li C, Chen L, Neochoritis CG, Liao GP, Zhou H, Dömling A, Moroni A, Wang W. Isocyanides as Influenza A Virus Subtype H5N1 Wild-Type M2 Channel Inhibitors. Chemmedchem. 10: 1837-45. PMID 26506405 DOI: 10.1002/cmdc.201500318  0.083
2021 Gouridis G, Muthahari YA, de Boer M, Griffith DA, Tsirigotaki A, Tassis K, Zijlstra N, Xu R, Eleftheriadis N, Sugijo Y, Zacharias M, Dömling A, Karamanou S, Pozidis C, Economou A, et al. Structural dynamics in the evolution of a bilobed protein scaffold. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34845009 DOI: 10.1073/pnas.2026165118  0.082
2022 Abdelraheem E, Lubberink M, Wang W, Li J, Reyes Romero A, van der Straat R, Du X, Groves M, Dömling A. Multicomponent Macrocyclic IL-17a Modifier. Acs Medicinal Chemistry Letters. 13: 1468-1471. PMID 36105327 DOI: 10.1021/acsmedchemlett.2c00257  0.079
2020 Kunig VBK, Potowski M, Akbarzadeh M, Klika Škopić M, Dos Santos Smith D, Arendt L, Dormuth I, Adihou H, Andlovic B, Karatas H, Shaabani S, Zarganes-Tzitzikas T, Neochoritis CG, Zhang R, Groves M, et al. TEAD-YAP interaction inhibitors and MDM2 binders from DNA-encoded indole-focused Ugi-peptidomimetics. Angewandte Chemie (International Ed. in English). PMID 32537835 DOI: 10.1002/anie.202006280  0.075
2005 Dömling A, Richter W. Myxobacterial epothilones and tubulysins as promising anticancer agents. Molecular Diversity. 9: 141-7. PMID 15789561  0.075
2011 Dömling A, Hulme C. Special issue on Mini-MCR issue and SCS-09--Second International Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials. Editorial. Molecular Diversity. 15: 1-2. PMID 21373985 DOI: 10.1007/S11030-011-9308-3  0.074
2017 Wapenaar H, van den Bosch T, Leus NGJ, van der Wouden PE, Eleftheriadis N, Hermans J, Hailu GS, Rotili D, Mai A, Dömling A, Bischoff R, Haisma HJ, Dekker FJ. The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. European Journal of Medicinal Chemistry. 136: 480-486. PMID 28527406 DOI: 10.1016/J.Ejmech.2017.05.015  0.072
2016 Zak KM, Grudnik P, Guzik K, Zieba BJ, Musielak B, Dömling A, Dubin G, Holak TA. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1). Oncotarget. 7: 30323-35. PMID 27083005 DOI: 10.18632/oncotarget.8730  0.069
2020 Oerlemans R, Ruiz-Moreno AJ, Cong Y, Dinesh Kumar N, Velasco-Velazquez MA, Neochoritis CG, Smith J, Reggiori F, Groves MR, Dömling A. Repurposing the HCV NS3-4A protease drug boceprevir as COVID-19 therapeutics. Rsc Medicinal Chemistry. 12: 370-379. PMID 34041486 DOI: 10.1039/d0md00367k  0.069
2019 Guzik K, Tomala M, Muszak D, Konieczny M, Hec A, Błaszkiewicz U, Pustuła M, Butera R, Dömling A, Holak TA. Development of the Inhibitors that Target the PD-1/PD-L1 Interaction-A Brief Look at Progress on Small Molecules, Peptides and Macrocycles. Molecules (Basel, Switzerland). 24. PMID 31151293 DOI: 10.3390/molecules24112071  0.069
2017 Skalniak L, Zak KM, Guzik K, Magiera K, Musielak B, Pachota M, Szelazek B, Kocik J, Grudnik P, Tomala M, Krzanik S, Pyrc K, Dömling A, Dubin G, Holak TA. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells Oncotarget. 8: 72167-72181. PMID 29069777 DOI: 10.18632/Oncotarget.20050  0.068
2018 Shaabani S, Huizinga HPS, Butera R, Kouchi A, Guzik K, Magiera-Mularz K, Holak TA, Dömling A. A patent review on PD-1/PD-L1 antagonists: small molecules, peptides and macrocycles (2015-2018). Expert Opinion On Therapeutic Patents. PMID 30107136 DOI: 10.1080/13543776.2018.1512706  0.066
2022 Deng ZF, Bakunina I, Yu H, Han J, Dömling A, Ferreira MU, Zhang JY. Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance. Frontiers in Pharmacology. 13: 815603. PMID 35418870 DOI: 10.3389/fphar.2022.815603  0.066
2015 Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, Dömling A, Dubin G, Holak TA. Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1. Structure (London, England : 1993). 23: 2341-2348. PMID 26602187 DOI: 10.1016/j.str.2015.09.010  0.066
2022 Zhang B, Dömling A. Small molecule modulators of IL-17A/IL-17RA: a patent review (2013-2021). Expert Opinion On Therapeutic Patents. 1-13. PMID 36350977 DOI: 10.1080/13543776.2022.2143264  0.063
2017 Magiera-Mularz K, Skalniak L, Zak KM, Musielak B, Rudzinska-Szostak E, Berlicki Ł, Kocik J, Grudnik P, Sala D, Zarganes-Tzitzikas T, Shaabani S, Dömling A, Dubin G, Holak TA. Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint. Angewandte Chemie (International Ed. in English). 56: 13732-13735. PMID 28881104 DOI: 10.1002/anie.201707707  0.063
2022 Shaabani S, Gadina L, Surmiak E, Wang Z, Zhang B, Butera R, Zarganes-Tzitzikas T, Rodriguez I, Kocik-Krol J, Magiera-Mularz K, Skalniak L, Dömling A, Holak TA. Biphenyl Ether Analogs Containing Pomalidomide as Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. Molecules (Basel, Switzerland). 27. PMID 35684392 DOI: 10.3390/molecules27113454  0.061
2010 Wang W, Joyner S, Khoury KA, Dömling A. (-)-Bacillamide C: the convergent approach. Organic & Biomolecular Chemistry. 8: 529-32. PMID 20090966 DOI: 10.1039/b918214d  0.059
2019 Ruiz-Moreno AJ, Torres-Barrera P, Velázquez-Paniagua M, Dömling A, Velasco-Velázquez MA. Guide for Selection of Relevant Cell Lines During the Evaluation of new Anti-Cancer Compounds. Anti-Cancer Agents in Medicinal Chemistry. 18: 1072-1081. PMID 29697026 DOI: 10.2174/1871520618666180220120544  0.058
2017 Zak KM, Grudnik P, Magiera K, Dömling A, Dubin G, Holak TA. Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2. Structure (London, England : 1993). 25: 1163-1174. PMID 28768162 DOI: 10.1016/j.str.2017.06.011  0.056
2021 Clemente GS, Antunes IF, Sijbesma JWA, van Waarde A, Lammertsma AA, Dömling A, Elsinga PH. [F]Atorvastatin Pharmacokinetics and Biodistribution in Healthy Female and Male Rats. Molecular Pharmaceutics. PMID 34351158 DOI: 10.1021/acs.molpharmaceut.1c00305  0.055
2018 Wang W, Groves MR, Dömling A. Artificial Macrocycles as IL-17A/IL-17RA Antagonists. Medchemcomm. 9: 22-26. PMID 29750108 DOI: 10.1039/C7MD00464H  0.054
2022 Deng J, Cheng Z, Long J, Dömling A, Tortorella M, Wang Y. Small Molecule Inhibitors of Programmed Cell Death Ligand 1 (PD-L1): A Patent Review (2019-2021). Expert Opinion On Therapeutic Patents. 1-15. PMID 35272536 DOI: 10.1080/13543776.2022.2045276  0.052
2022 Shan J, Megarbane A, Chouchane A, Karthik D, Temanni R, Reyes Romero A, Hua H, Pan C, Chen X, Subramanian M, Saad C, Mbarek H, Mehawej C, Chouery E, Abuaqel SW, et al. Genetic predisposition to porto-sinusoidal vascular disorder: a functional genomic-based, multi-generational family study. Hepatology (Baltimore, Md.). PMID 35989577 DOI: 10.1002/hep.32735  0.052
2023 Almuraikhy S, Anwardeen N, Doudin A, Sellami M, Domling A, Agouni A, Al Thani AA, Elrayess MA. The Metabolic Switch of Physical Activity in Non-Obese Insulin Resistant Individuals. International Journal of Molecular Sciences. 24. PMID 37175541 DOI: 10.3390/ijms24097816  0.049
2021 Al-Muraikhy S, Ramanjaneya M, Dömling AS, Bettahi I, Donati F, Botre F, Abou-Samra AB, Sellami M, Elrayess MA. High Endurance Elite Athletes Show Age-dependent Lower Levels of Circulating Complements Compared to Low/Moderate Endurance Elite Athletes. Frontiers in Molecular Biosciences. 8: 715035. PMID 34631796 DOI: 10.3389/fmolb.2021.715035  0.048
2020 Bashraheel SS, Domling A, Goda SK. Update on targeted cancer therapies, single or in combination, and their fine tuning for precision medicine. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 125: 110009. PMID 32106381 DOI: 10.1016/j.biopha.2020.110009  0.042
2023 Almuraikhy S, Doudin A, Domling A, Althani AAJF, Elrayess MA. Molecular regulators of exercise-mediated insulin sensitivity in non-obese individuals. Journal of Cellular and Molecular Medicine. 28: e18015. PMID 37938877 DOI: 10.1111/jcmm.18015  0.041
2023 Rashidi FB, Al-Qahtani AD, Bashraheel SS, Shaabani S, Groves MR, Dömling A, Goda SK. Correction: Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment. Plos One. 18: e0294885. PMID 37988359 DOI: 10.1371/journal.pone.0294885  0.04
2014 Dömling A, Holak TA. Programmed death-1: therapeutic success after more than 100 years of cancer immunotherapy. Angewandte Chemie (International Ed. in English). 53: 2286-8. PMID 24474145 DOI: 10.1002/anie.201307906  0.034
2013 Zak K, Pecak A, Rys B, Wladyka B, Dömling A, Weber L, Holak TA, Dubin G. Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011-present). Expert Opinion On Therapeutic Patents. 23: 425-48. PMID 23374098 DOI: 10.1517/13543776.2013.765405  0.034
2017 Guzik K, Zak KM, Grudnik P, Magiera K, Musielak B, Törner R, Skalniak L, Dömling A, Dubin G, Holak TA. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. Journal of Medicinal Chemistry. 60: 5857-5867. PMID 28613862 DOI: 10.1021/acs.jmedchem.7b00293  0.033
2011 Dömling A, Khoury K. Praziquantel and schistosomiasis. Chemmedchem. 5: 1420-34. PMID 20677314 DOI: 10.1002/cmdc.201000202  0.029
2023 Almuraikhy S, Sellami M, Al-Amri HS, Domling A, Althani AA, Elrayess MA. Impact of Moderate Physical Activity on Inflammatory Markers and Telomere Length in Sedentary and Moderately Active Individuals with Varied Insulin Sensitivity. Journal of Inflammation Research. 16: 5427-5438. PMID 38026244 DOI: 10.2147/JIR.S429899  0.025
2022 AlMuraikhy S, Anwardeen N, Naeem A, Sellami M, Domling A, Agouni A, Elrayess MA. Comparing the Metabolic Profiles Associated with Fitness Status between Insulin-Sensitive and Insulin-Resistant Non-Obese Individuals. International Journal of Environmental Research and Public Health. 19. PMID 36231474 DOI: 10.3390/ijerph191912169  0.02
2016 Zarganes-Tzitzikas T, Konstantinidou M, Gao Y, Krzemien D, Zak K, Dubin G, Holak TA, Dömling A. Inhibitors of programmed cell death 1 (PD-1): a patent review (2010-2015). Expert Opinion On Therapeutic Patents. PMID 27367741 DOI: 10.1080/13543776.2016.1206527  0.014
2009 Dömling A. Hot, hotter, hottest. Cell Cycle (Georgetown, Tex.). 8: 1112. PMID 19342883 DOI: 10.4161/cc.8.8.8475  0.01
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