Mortimer Poncz - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biochemistry, Molecular Biology

58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Gollomp K, Kim M, Johnston I, Hayes V, Welsh J, Arepally GM, Kahn M, Lambert MP, Cuker A, Cines DB, Rauova L, Kowalska MA, Poncz M. Neutrophil accumulation and NET release contribute to thrombosis in HIT. Jci Insight. 3. PMID 30232279 DOI: 10.1172/jci.insight.99445  0.32
2018 Revel-Vilk S, Shai E, Turro E, Jahshan N, Hi-Am E, Spectre G, Daum H, Kalish Y, Althaus K, Greinacher A, Kaplinsky C, Izraeli S, Mapeta R, Deevi SVV, Jarocha D, ... ... Poncz M, et al. GNE variants causing autosomal recessive macrothrombocytopenia without associated muscle wasting. Blood. PMID 30171045 DOI: 10.1182/blood-2018-04-845545  0.32
2018 Tkaczynski E, Arulselvan A, Tkaczynski J, Avery S, Xiao L, Torok-Storb B, Abrams K, Rao NV, Johnson G, Kennedy TP, Poncz M, Lambert MP. 2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia. Blood Advances. 2: 754-761. PMID 29599195 DOI: 10.1182/bloodadvances.2017013672  0.32
2017 Gollomp K, Lambert MP, Poncz M. Current status of blood 'pharming': megakaryoctye transfusions as a source of platelets. Current Opinion in Hematology. 24: 565-571. PMID 28985194 DOI: 10.1097/MOH.0000000000000378  0.32
2017 Hanby HA, Bao J, Noh JY, Jarocha D, Poncz M, Weiss MJ, Marks MS. Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formation. Blood Advances. 1: 1478-1490. PMID 28936487 DOI: 10.1182/bloodadvances.2017006726  0.56
2015 Fuentes RE, Zaitsev S, Ahn HS, Hayes V, Kowalska MA, Lambert MP, Wang Y, Siegel DL, Bougie DW, Aster RH, Myers DD, Stepanova V, Cines DB, Muzykantov VR, Poncz M. A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation. The Journal of Clinical Investigation. PMID 26690701 DOI: 10.1172/JCI81470  0.56
2015 Noh JY, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, ... Poncz M, et al. Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. The Journal of Clinical Investigation. 125: 2369-74. PMID 25961454 DOI: 10.1172/JCI77670  0.56
2015 Wang Y, Hayes V, Jarocha D, Sim X, Harper DC, Fuentes R, Sullivan SK, Gadue P, Chou ST, Torok-Storb BJ, Marks MS, French DL, Poncz M. Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale. Blood. 125: 3627-36. PMID 25852052 DOI: 10.1182/blood-2014-08-593053  0.56
2014 Bruns I, Lucas D, Pinho S, Ahmed J, Lambert MP, Kunisaki Y, Scheiermann C, Schiff L, Poncz M, Bergman A, Frenette PS. Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nature Medicine. 20: 1315-20. PMID 25326802 DOI: 10.1038/nm.3707  0.32
2014 Greene TK, Lyde RB, Bailey SC, Lambert MP, Zhai L, Sabatino DE, Camire RM, Arruda VR, Poncz M. Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet-based gene therapy. Journal of Thrombosis and Haemostasis : Jth. 12: 2102-12. PMID 25287191 DOI: 10.1111/jth.12749  0.56
2014 Skewis LR, Lebedeva T, Papkov V, Thayer EC, Massefski W, Cuker A, Nagaswami C, Litvinov RI, Kowalska MA, Rauova L, Poncz M, Weisel JW, Lowery TJ, Cines DB. T2 magnetic resonance: a diagnostic platform for studying integrated hemostasis in whole blood--proof of concept. Clinical Chemistry. 60: 1174-82. PMID 24958814 DOI: 10.1373/clinchem.2014.223735  0.56
2014 Noh JY, Weiss MJ, Poncz M. Personalized platelet transfusions: one step closer to the clinic. Cell Stem Cell. 14: 425-6. PMID 24702993 DOI: 10.1016/j.stem.2014.03.012  0.56
2014 Shi G, Field DJ, Ko KA, Ture S, Srivastava K, Levy S, Kowalska MA, Poncz M, Fowell DJ, Morrell CN. Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection. The Journal of Clinical Investigation. 124: 543-52. PMID 24463452 DOI: 10.1172/JCI71858  0.56
2014 Sullivan SK, Mills JA, Koukouritaki SB, Vo KK, Lyde RB, Paluru P, Zhao G, Zhai L, Sullivan LM, Wang Y, Kishore S, Gharaibeh EZ, Lambert MP, Wilcox DA, French DL, ... Poncz M, et al. High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. Blood. 123: 753-7. PMID 24335497 DOI: 10.1182/blood-2013-10-530725  0.56
2014 Lian L, Suzuki A, Hayes V, Saha S, Han X, Xu T, Yates JR, Poncz M, Kashina A, Abrams CS. Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation. Haematologica. 99: 554-60. PMID 24293517 DOI: 10.3324/haematol.2013.093047  0.56
2014 Kowalska MA, Zhao G, Zhai L, David G, Marcus S, Krishnaswamy S, Poncz M. Modulation of protein C activation by histones, platelet factor 4, and heparinoids: new insights into activated protein C formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 120-6. PMID 24177324 DOI: 10.1161/ATVBAHA.113.302236  0.56
2013 Lambert MP, Sullivan SK, Fuentes R, French DL, Poncz M. Challenges and promises for the development of donor-independent platelet transfusions. Blood. 121: 3319-24. PMID 23321255 DOI: 10.1182/blood-2012-09-455428  0.56
2013 Zhi H, Rauova L, Hayes V, Gao C, Boylan B, Newman DK, McKenzie SE, Cooley BC, Poncz M, Newman PJ. Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood. 121: 1858-67. PMID 23264598 DOI: 10.1182/blood-2012-07-443325  0.56
2012 Love MS, Millholland MG, Mishra S, Kulkarni S, Freeman KB, Pan W, Kavash RW, Costanzo MJ, Jo H, Daly TM, Williams DR, Kowalska MA, Bergman LW, Poncz M, DeGrado WF, et al. Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell Host & Microbe. 12: 815-23. PMID 23245326 DOI: 10.1016/j.chom.2012.10.017  0.56
2012 Meng R, Wang Y, Yao Y, Zhang Z, Harper DC, Heijnen HF, Sitaram A, Li W, Raposo G, Weiss MJ, Poncz M, Marks MS. SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. Blood. 120: 404-14. PMID 22611153 DOI: 10.1182/blood-2011-11-389551  0.56
2012 Sachais BS, Litvinov RI, Yarovoi SV, Rauova L, Hinds JL, Rux AH, Arepally GM, Poncz M, Cuker A, Weisel JW, Cines DB. Dynamic antibody-binding properties in the pathogenesis of HIT. Blood. 120: 1137-42. PMID 22577175 DOI: 10.1182/blood-2012-01-407262  0.56
2012 Zaitsev S, Kowalska MA, Neyman M, Carnemolla R, Tliba S, Ding BS, Stonestrom A, Spitzer D, Atkinson JP, Poncz M, Cines DB, Esmon CT, Muzykantov VR. Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. Blood. 119: 4779-85. PMID 22493296 DOI: 10.1182/blood-2011-12-398149  0.56
2011 Greene TK, Lambert MP, Poncz M. Ectopic platelet-delivered factor (F) VIII for the treatment of Hemophilia A: Plasma and platelet FVIII, is it all the same? Journal of Genetic Syndromes & Gene Therapy. PMID 24319630 DOI: 10.4172/2157-7412.S1-001  0.32
2011 Wang Y, Meng R, Hayes V, Fuentes R, Yu X, Abrams CS, Heijnen HF, Blobel GA, Marks MS, Poncz M. Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction. Blood. 118: 6183-91. PMID 21989988 DOI: 10.1182/blood-2011-06-363580  0.56
2011 Ahmad F, Boulaftali Y, Greene TK, Ouellette TD, Poncz M, Feske S, Bergmeier W. Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis. Journal of Thrombosis and Haemostasis : Jth. 9: 2077-86. PMID 21848641 DOI: 10.1111/j.1538-7836.2011.04474.x  0.32
2011 Kowalska MA, Krishnaswamy S, Rauova L, Zhai L, Hayes V, Amirikian K, Esko JD, Bougie DW, Aster RH, Cines DB, Poncz M. Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT. Blood. 118: 2882-8. PMID 21772054 DOI: 10.1182/blood-2011-02-335208  0.56
2011 Lambert MP, Xiao L, Nguyen Y, Kowalska MA, Poncz M. The role of platelet factor 4 in radiation-induced thrombocytopenia. International Journal of Radiation Oncology, Biology, Physics. 80: 1533-40. PMID 21740995 DOI: 10.1016/j.ijrobp.2011.03.039  0.56
2011 DiCarlo AL, Poncz M, Cassatt DR, Shah JR, Czarniecki CW, Maidment BW. Medical countermeasures for platelet regeneration after radiation exposure. Report of a workshop and guided discussion sponsored by the National Institute of Allergy and Infectious Diseases, Bethesda, MD, March 22–23, 2010. Radiation Research. 176: e0001-15. PMID 21545291 DOI: 10.1667/RROL01.1  0.56
2011 DiCarlo AL, Poncz M, Cassatt DR, Shah JR, Czarniecki CW, Maidment BW. Development and licensure of medical countermeasures for platelet regeneration after radiation exposure. Radiation Research. 176: 134-7. PMID 21545289 DOI: 10.1667/RR2610.1  0.56
2011 Stolla M, Stefanini L, Roden RC, Chavez M, Hirsch J, Greene T, Ouellette TD, Maloney SF, Diamond SL, Poncz M, Woulfe DS, Bergmeier W. The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy. Blood. 117: 1005-13. PMID 20971951 DOI: 10.1182/blood-2010-07-297713  0.56
2010 Greene TK, Schiviz A, Hoellriegl W, Poncz M, Muchitsch EM. Towards a standardization of the murine tail bleeding model. Journal of Thrombosis and Haemostasis : Jth. 8: 2820-2. PMID 21138523 DOI: 10.1111/j.1538-7836.2010.04084.x  0.32
2010 Greene TK, Wang C, Hirsch JD, Zhai L, Gewirtz J, Thornton MA, Miao HZ, Pipe SW, Kaufman RJ, Camire RM, Arruda VR, Kowalska MA, Poncz M. In vivo efficacy of platelet-delivered, high specific activity factor VIII variants. Blood. 116: 6114-22. PMID 20852129 DOI: 10.1182/blood-2010-06-293308  0.56
2010 Rauova L, Hirsch JD, Greene TK, Zhai L, Hayes VM, Kowalska MA, Cines DB, Poncz M. Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia. Blood. 116: 5021-31. PMID 20724543 DOI: 10.1182/blood-2010-03-276964  0.32
2010 Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S, Poncz M, Lee JS, Worthen GS. CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity. 33: 106-17. PMID 20643340 DOI: 10.1016/j.immuni.2010.07.009  0.56
2010 Zaitsev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Marcos-Contreras OA, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR. Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood. 115: 5241-8. PMID 20410503 DOI: 10.1182/blood-2010-01-261610  0.56
2010 Gregory GD, Miccio A, Bersenev A, Wang Y, Hong W, Zhang Z, Poncz M, Tong W, Blobel GA. FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. Blood. 115: 2156-66. PMID 20065294 DOI: 10.1182/blood-2009-10-251280  0.56
2010 Zaitsev S, Zaitzev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Bdeir K, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR. Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. The Journal of Pharmacology and Experimental Therapeutics. 332: 1022-31. PMID 19952305 DOI: 10.1124/jpet.109.159194  0.56
2010 Miccio A, Wang Y, Hong W, Gregory GD, Wang H, Yu X, Choi JK, Shelat S, Tong W, Poncz M, Blobel GA. NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. The Embo Journal. 29: 442-56. PMID 19927129 DOI: 10.1038/emboj.2009.336  0.56
2009 Lambert MP, Wang Y, Bdeir KH, Nguyen Y, Kowalska MA, Poncz M. Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. Blood. 114: 2290-8. PMID 19605848 DOI: 10.1182/blood-2009-04-216473  0.56
2009 Blue R, Kowalska MA, Hirsch J, Murcia M, Janczak CA, Harrington A, Jirouskova M, Li J, Fuentes R, Thornton MA, Filizola M, Poncz M, Coller BS. Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. Blood. 114: 195-201. PMID 19414864 DOI: 10.1182/blood-2008-08-169243  0.56
2009 Basani RB, Zhu H, Thornton MA, Soto CS, Degrado WF, Kowalska MA, Bennett JS, Poncz M. Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence differences in 2 loops of the alpha IIb beta propeller. Blood. 113: 902-10. PMID 18987357 DOI: 10.1182/blood-2008-09-177337  0.56
2007 Suvarna S, Espinasse B, Qi R, Lubica R, Poncz M, Cines DB, Wiesner MR, Arepally GM. Determinants of PF4/heparin immunogenicity. Blood. 110: 4253-60. PMID 17848616 DOI: 10.1182/blood-2007-08-105098  0.56
2007 Kowalska MA, Mahmud SA, Lambert MP, Poncz M, Slungaard A. Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge. Blood. 110: 1903-5. PMID 17540840 DOI: 10.1182/blood-2007-03-081901  0.56
2007 Lambert MP, Rauova L, Bailey M, Sola-Visner MC, Kowalska MA, Poncz M. Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. Blood. 110: 1153-60. PMID 17495129 DOI: 10.1182/blood-2007-01-067116  0.56
2007 Muntean AG, Pang L, Poncz M, Dowdy SF, Blobel GA, Crispino JD. Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization. Blood. 109: 5199-207. PMID 17317855 DOI: 10.1182/blood-2006-11-059378  0.56
2007 Cines DB, Rauova L, Arepally G, Reilly MP, McKenzie SE, Sachais BS, Poncz M. Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly. Journal of Clinical Apheresis. 22: 31-6. PMID 17285619 DOI: 10.1002/jca.20109  0.56
2006 Pang L, Xue HH, Szalai G, Wang X, Wang Y, Watson DK, Leonard WJ, Blobel GA, Poncz M. Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood. 108: 2198-206. PMID 16757682 DOI: 10.1182/blood-2006-04-019760  0.56
2005 Pang L, Weiss MJ, Poncz M. Megakaryocyte biology and related disorders. The Journal of Clinical Investigation. 115: 3332-8. PMID 16322777 DOI: 10.1172/JCI26720  0.56
2005 Suvarna S, Rauova L, McCracken EK, Goss CM, Sachais BS, McKenzie SE, Reilly MP, Gunn MD, Cines DB, Poncz M, Arepally G. PF4/heparin complexes are T cell-dependent antigens. Blood. 106: 929-31. PMID 15845897 DOI: 10.1182/blood-2004-12-4955  0.56
2005 Rauova L, Poncz M, McKenzie SE, Reilly MP, Arepally G, Weisel JW, Nagaswami C, Cines DB, Sachais BS. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood. 105: 131-8. PMID 15304392 DOI: 10.1182/blood-2004-04-1544  0.56
2003 Pitsilos S, Hunt J, Mohler ER, Prabhakar AM, Poncz M, Dawicki J, Khalapyan TZ, Wolfe ML, Fairman R, Mitchell M, Carpenter J, Golden MA, Cines DB, Sachais BS. Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters. Thrombosis and Haemostasis. 90: 1112-20. PMID 14652645 DOI: 10.1160/TH03-02-0069  0.56
2003 Poncz M, Iannone R, Werner EM. Hematology grants workshop. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 590-6. PMID 14633801  0.56
2003 Yarovoi HV, Kufrin D, Eslin DE, Thornton MA, Haberichter SL, Shi Q, Zhu H, Camire R, Fakharzadeh SS, Kowalska MA, Wilcox DA, Sachais BS, Montgomery RR, Poncz M. Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. Blood. 102: 4006-13. PMID 12881300 DOI: 10.1182/blood-2003-05-1519  0.56
2003 Kufrin D, Eslin DE, Bdeir K, Murciano JC, Kuo A, Kowalska MA, Degen JL, Sachais BS, Cines DB, Poncz M. Antithrombotic thrombocytes: Ectopic expression of urokinase-type plasminogen activator in platelets Blood. 102: 926-933. PMID 12689937 DOI: 10.1182/blood-2003-01-0054  0.56
2003 Rozmyslowicz T, Majka M, Kijowski J, Murphy SL, Conover DO, Poncz M, Ratajczak J, Gaulton GN, Ratajczak MZ. Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. Aids (London, England). 17: 33-42. PMID 12478067 DOI: 10.1097/01.aids.0000042948.95433.3d  0.56
2002 Thornton MA, Zhang C, Kowalska MA, Poncz M. Identification of distal regulatory regions in the human alpha IIb gene locus necessary for consistent, high-level megakaryocyte expression. Blood. 100: 3588-96. PMID 12393463 DOI: 10.1182/blood-2002-05-1307  0.56
2002 Wang X, Crispino JD, Letting DL, Nakazawa M, Poncz M, Blobel GA. Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors. The Embo Journal. 21: 5225-34. PMID 12356738 DOI: 10.1093/emboj/cdf527  0.56
2002 Fang J, Hsu BY, MacMullen CM, Poncz M, Smith TJ, Stanley CA. Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations. The Biochemical Journal. 363: 81-7. PMID 11903050 DOI: 10.1042/0264-6021:3630081  0.56
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