Karen S. Anderson - Publications

Affiliations: 
Pharmacology Yale University School of Medicine, New Haven, CT 

90 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ghahremanpour MM, Tirado-Rives J, Deshmukh M, Ippolito JA, Zhang CH, de Vaca IC, Liosi ME, Anderson KS, Jorgensen WL. Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 32869018 DOI: 10.1101/2020.08.28.271957  0.48
2020 Gannam ZTK, Min K, Shillingford SR, Zhang L, Herrington J, Abriola L, Gareiss PC, Pantouris G, Tzouvelekis A, Kaminski N, Zhang X, Yu J, Jamali H, Ellman JA, Lolis E, ... Anderson KS, et al. An allosteric site on MKP5 reveals a strategy for small-molecule inhibition. Science Signaling. 13. PMID 32843541 DOI: 10.1126/scisignal.aba3043  0.4
2020 Duong VN, Ippolito JA, Chan AH, Lee WG, Spasov KA, Jorgensen WL, Anderson KS. Structural Investigation of 2-Naphthyl Phenyl Ether Inhibitors Bound to WT and Y181C Reverse Transcriptase Highlights Key Features of the NNRTI Binding Site. Protein Science : a Publication of the Protein Society. PMID 32643196 DOI: 10.1002/pro.3910  0.48
2020 Ruiz VG, Czyzyk DJ, Kumar VP, Jorgensen WL, Anderson KS. Targeting the TS dimer interface in bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa: Virtual screening identifies novel TS allosteric inhibitors. Bioorganic & Medicinal Chemistry Letters. 30: 127292. PMID 32631514 DOI: 10.1016/j.bmcl.2020.127292  0.48
2020 Newton AS, Faver JC, Micevic G, Muthusamy V, Kudalkar SN, Bertoletti N, Anderson KS, Bosenberg MW, Jorgensen WL. Structure-Guided Identification of DNMT3B Inhibitors. Acs Medicinal Chemistry Letters. 11: 971-976. PMID 32435413 DOI: 10.1021/acsmedchemlett.0c00011  0.48
2019 Sasaki T, Gannam ZTK, Kudalkar SN, Frey KM, Lee WG, Spasov KA, Jorgensen WL, Anderson KS. Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. PMID 31281023 DOI: 10.1016/j.bmcl.2019.06.047  0.48
2019 Czyzyk DJ, Valhondo M, Jorgensen WL, Anderson KS. Understanding the Structural Basis of Species Selective, Stereospecific Inhibition for Cryptosporidium and Human Thymidylate Synthase. Febs Letters. PMID 31172516 DOI: 10.1002/1873-3468.13474  0.48
2019 Kudalkar SN, Ullah I, Bertoletti N, Mandl HK, Cisneros JA, Beloor J, Chan AH, Quijano E, Saltzman WM, Jorgensen WL, Kumar P, Anderson KS. Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV. Antiviral Research. PMID 31034849 DOI: 10.1016/j.antiviral.2019.04.010  0.48
2019 Ruiz V, Czyzyk DJ, Valhondo M, Jorgensen WL, Anderson KS. Novel allosteric covalent inhibitors of bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa identified by virtual screening. Bioorganic & Medicinal Chemistry Letters. PMID 30929953 DOI: 10.1016/j.bmcl.2019.03.022  0.48
2019 Cannataro VL, Gaffney SG, Sasaki T, Issaeva N, Grewal NKS, Grandis JR, Yarbrough WG, Burtness B, Anderson KS, Townsend JP. APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma. Oncogene. PMID 30647454 DOI: 10.1038/s41388-018-0657-6  0.4
2018 Sasaki T, Kudalkar SN, Bertoletti N, Anderson KS. DRONE: Direct Tracking of DNA Cytidine Deamination and Other DNA Modifying Activities. Analytical Chemistry. PMID 30256094 DOI: 10.1021/acs.analchem.8b01405  0.4
2018 Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS. Reply to Pandey et al.: Understanding the efficacy of a potential antiretroviral drug candidate in humanized mouse model of HIV infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 30097540 DOI: 10.1073/pnas.1810136115  0.48
2018 Ziegler SJ, Liu C, Landau M, Buzovetsky O, Desimmie BA, Zhao Q, Sasaki T, Burdick RC, Pathak VK, Anderson KS, Xiong Y. Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies. Plos One. 13: e0195048. PMID 29596531 DOI: 10.1371/journal.pone.0195048  0.4
2017 Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS. From in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 29279368 DOI: 10.1073/pnas.1717932115  0.48
2017 Chan AH, Lee WG, Spasov KA, Cisneros JA, Kudalkar SN, Petrova ZO, Buckingham AB, Anderson KS, Jorgensen WL. Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography. Proceedings of the National Academy of Sciences of the United States of America. PMID 28827354 DOI: 10.1073/pnas.1711463114  0.48
2017 Kudalkar SN, Beloor J, Chan AH, Lee WG, Jorgensen WL, Kumar P, Anderson KS. Structural and Preclinical Studies of Computationally-Designed Non-nucleoside Reverse Transcriptase Inhibitors for Treating HIV infection. Molecular Pharmacology. PMID 28167742 DOI: 10.1124/mol.116.107755  0.48
2016 Lee WG, Chan AH, Spasov KA, Anderson KS, Jorgensen WL. Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents. Acs Medicinal Chemistry Letters. 7: 1156-1160. PMID 27994756 DOI: 10.1021/acsmedchemlett.6b00390  0.48
2016 Li M, Mislak AC, Foli Y, Agbosu E, Bose V, Bhandari S, Szymanski MR, Shumate CK, Yin YW, Anderson KS, Paintsil E. DNA Polymerase-γ R953C Mutant is Associated with ART-Induced Mitochondrial Toxicity. Antimicrobial Agents and Chemotherapy. PMID 27381400 DOI: 10.1128/AAC.00976-16  0.6
2015 Mislak AC, Anderson KS. Insights into the Molecular Mechanism of Polymerization and NRTI Incorporation for Human PrimPol. Antimicrobial Agents and Chemotherapy. PMID 26552983 DOI: 10.1128/AAC.02270-15  0.6
2015 Gray WT, Frey KM, Laskey SB, Mislak AC, Spasov KA, Lee WG, Bollini M, Siliciano RF, Jorgensen WL, Anderson KS. Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance. Acs Medicinal Chemistry Letters. 6: 1075-9. PMID 26487915 DOI: 10.1021/acsmedchemlett.5b00254  0.6
2015 Lee WG, Frey KM, Gallardo-Macias R, Spasov KA, Chan AH, Anderson KS, Jorgensen WL. Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 25: 4824-7. PMID 26166629 DOI: 10.1016/j.bmcl.2015.06.074  0.48
2015 Sohl CD, Szymanski MR, Mislak AC, Shumate CK, Amiralaei S, Schinazi RF, Anderson KS, Yin YW. Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ. Proceedings of the National Academy of Sciences of the United States of America. 112: 8596-601. PMID 26124101 DOI: 10.1073/pnas.1421733112  0.6
2015 Mukerjee A, Iyidogan P, Castellanos-Gonzalez A, Cisneros JA, Czyzyk D, Ranjan AP, Jorgensen WL, White AC, Vishwanatha JK, Anderson KS. A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium. Bioorganic & Medicinal Chemistry Letters. 25: 2065-7. PMID 25900220 DOI: 10.1016/j.bmcl.2015.03.091  0.6
2015 Frey KM, Puleo DE, Spasov KA, Bollini M, Jorgensen WL, Anderson KS. Structure-based evaluation of non-nucleoside inhibitors with improved potency and solubility that target HIV reverse transcriptase variants. Journal of Medicinal Chemistry. 58: 2737-45. PMID 25700160 DOI: 10.1021/jm501908a  0.6
2015 Sohl CD, Ryan MR, Luo B, Frey KM, Anderson KS. Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy. Acs Chemical Biology. 10: 1319-29. PMID 25686244 DOI: 10.1021/acschembio.5b00014  0.48
2015 Kim Y, Apetri M, Luo B, Settleman JE, Anderson KS. Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors. Molecular Cancer Research : McR. 13: 765-74. PMID 25573954 DOI: 10.1158/1541-7786.MCR-14-0326  0.6
2014 Lee WG, Frey KM, Gallardo-Macias R, Spasov KA, Bollini M, Anderson KS, Jorgensen WL. Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers. Acs Medicinal Chemistry Letters. 5: 1259-62. PMID 25408842 DOI: 10.1021/ml5003713  0.6
2014 Parker CG, Dahlgren MK, Tao RN, Li DT, Douglass EF, Shoda T, Jawanda N, Spasov KA, Lee S, Zhou N, Domaoal RA, Sutton RE, Anderson KS, Jorgensen WL, Krystal M, et al. Illuminating HIV gp120-Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules. Chemical Science (Royal Society of Chemistry : 2010). 5: 2311-2317. PMID 25379167 DOI: 10.1039/C4SC00484A  0.6
2014 Iyidogan P, Anderson KS. Current perspectives on HIV-1 antiretroviral drug resistance. Viruses. 6: 4095-139. PMID 25341668 DOI: 10.3390/v6104095  0.6
2014 Kumar VP, Cisneros JA, Frey KM, Castellanos-Gonzalez A, Wang Y, Gangjee A, White AC, Jorgensen WL, Anderson KS. Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase. Bioorganic & Medicinal Chemistry Letters. 24: 4158-61. PMID 25127103 DOI: 10.1016/j.bmcl.2014.07.049  0.6
2014 Towle-Weicksel JB, Dalal S, Sohl CD, Doublie S, Anderson KS, Sweasy JB. Fluorescence resonance energy transfer studies of DNA polymerase β the critical role of fingers domain movements and a novel non-covalent step During nucleotide selection Journal of Biological Chemistry. 289: 16541-16550. PMID 24764311 DOI: 10.1074/jbc.M114.561878  0.6
2014 Mislak AC, Frey KM, Bollini M, Jorgensen WL, Anderson KS. A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase. Biochimica Et Biophysica Acta. 1840: 2203-11. PMID 24726448 DOI: 10.1016/j.bbagen.2014.04.001  0.6
2014 Muftuoglu Y, Sohl CD, Mislak AC, Mitsuya H, Sarafianos SG, Anderson KS. Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kinetics. Antiviral Research. 106: 1-4. PMID 24632447 DOI: 10.1016/j.antiviral.2014.03.001  0.6
2014 Sharma H, Landau MJ, Sullivan TJ, Kumar VP, Dahlgren MK, Jorgensen WL, Anderson KS. Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductase. Bioorganic & Medicinal Chemistry Letters. 24: 1232-5. PMID 24440298 DOI: 10.1016/j.bmcl.2013.12.039  0.6
2014 Frey KM, Gray WT, Spasov KA, Bollini M, Gallardo-Macias R, Jorgensen WL, Anderson KS. Structure-based evaluation of C5 derivatives in the catechol diether series targeting HIV-1 reverse transcriptase. Chemical Biology & Drug Design. 83: 541-9. PMID 24289305 DOI: 10.1111/cbdd.12266  0.6
2014 Iyidogan P, Anderson KS. Recent findings on the mechanisms involved in tenofovir resistance. Antiviral Chemistry & Chemotherapy. 23: 217-22. PMID 23744599 DOI: 10.3851/IMP2628  0.4
2013 Iyidogan P, Sullivan TJ, Chordia MD, Frey KM, Anderson KS. Design, Synthesis, and Antiviral Evaluation of Chimeric Inhibitors of HIV Reverse Transcriptase. Acs Medicinal Chemistry Letters. 4: 1183-8. PMID 24900627 DOI: 10.1021/ml4002979  0.6
2013 Zaware N, Sharma H, Yang J, Devambatla RK, Queener SF, Anderson KS, Gangjee A. Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections. Acs Medicinal Chemistry Letters. 4: 1148-1151. PMID 24470841 DOI: 10.1021/ml400208v  0.6
2013 Martucci WE, Rodriguez JM, Vargo MA, Marr M, Hamilton AD, Anderson KS. Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein-protein interaction in C. hominis TS-DHFR. Medchemcomm. 4. PMID 24324854 DOI: 10.1039/C3MD00141E  0.6
2013 Lee WG, Gallardo-Macias R, Frey KM, Spasov KA, Bollini M, Anderson KS, Jorgensen WL. Picomolar inhibitors of HIV reverse transcriptase featuring bicyclic replacement of a cyanovinylphenyl group. Journal of the American Chemical Society. 135: 16705-13. PMID 24151856 DOI: 10.1021/ja408917n  0.6
2013 Sharma H, Landau MJ, Vargo MA, Spasov KA, Anderson KS. First three-dimensional structure of Toxoplasma gondii thymidylate synthase-dihydrofolate reductase: insights for catalysis, interdomain interactions, and substrate channeling. Biochemistry. 52: 7305-17. PMID 24053355 DOI: 10.1021/bi400576t  0.6
2013 Bollini M, Cisneros JA, Spasov KA, Anderson KS, Jorgensen WL. Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility. Bioorganic & Medicinal Chemistry Letters. 23: 5213-6. PMID 23937980 DOI: 10.1016/j.bmcl.2013.06.091  0.6
2013 Kumar VP, Frey KM, Wang Y, Jain HK, Gangjee A, Anderson KS. Substituted pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 5426-8. PMID 23927969 DOI: 10.1016/j.bmcl.2013.07.037  0.6
2013 Bollini M, Frey KM, Cisneros JA, Spasov KA, Das K, Bauman JD, Arnold E, Anderson KS, Jorgensen WL. Extension into the entrance channel of HIV-1 reverse transcriptase--crystallography and enhanced solubility. Bioorganic & Medicinal Chemistry Letters. 23: 5209-12. PMID 23899617 DOI: 10.1016/j.bmcl.2013.06.093  0.6
2013 Landau MJ, Sharma H, Anderson KS. Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation. Protein Science : a Publication of the Protein Society. 22: 1161-73. PMID 23813474 DOI: 10.1002/pro.2300  0.6
2013 Bailey CM, Sullivan TJ, Iyidogan P, Tirado-Rives J, Chung R, Ruiz-Caro J, Mohamed E, Jorgensen WL, Jorgensen W, Hunter R, Anderson KS. Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy. Journal of Medicinal Chemistry. 56: 3959-68. PMID 23659183 DOI: 10.1021/jm400160s  0.6
2013 Piao D, Basavapathruni A, Iyidogan P, Dai G, Hinz W, Ray AS, Murakami E, Feng JY, You F, Dutschman GE, Austin DJ, Parker KA, Anderson KS. Bifunctional inhibition of HIV-1 reverse transcriptase: a first step in designing a bifunctional triphosphate. Bioorganic & Medicinal Chemistry Letters. 23: 1511-8. PMID 23380374 DOI: 10.1016/j.bmcl.2012.12.015  0.6
2013 Bollini M, Gallardo-Macias R, Spasov KA, Tirado-Rives J, Anderson KS, Jorgensen WL. Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency. Bioorganic & Medicinal Chemistry Letters. 23: 1110-3. PMID 23298809 DOI: 10.1016/j.bmcl.2012.11.115  0.6
2013 Sohl CD, Kasiviswanathan R, Copeland WC, Anderson KS. Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients. Human Molecular Genetics. 22: 1074-85. PMID 23208208 DOI: 10.1093/hmg/dds509  0.6
2012 Frey KM, Bollini M, Mislak AC, Cisneros JA, Gallardo-Macias R, Jorgensen WL, Anderson KS. Crystal structures of HIV-1 reverse transcriptase with picomolar inhibitors reveal key interactions for drug design. Journal of the American Chemical Society. 134: 19501-3. PMID 23163887 DOI: 10.1021/ja3092642  0.6
2012 Iyidogan P, Anderson KS. Understanding the molecular mechanism of sequence dependent tenofovir removal by HIV-1 reverse transcriptase: differences in primer binding site versus polypurine tract. Antiviral Research. 95: 93-103. PMID 22664235 DOI: 10.1016/j.antiviral.2012.05.012  0.6
2012 Kim Y, Li Z, Apetri M, Luo B, Settleman JE, Anderson KS. Temporal resolution of autophosphorylation for normal and oncogenic forms of EGFR and differential effects of gefitinib. Biochemistry. 51: 5212-22. PMID 22657099 DOI: 10.1021/bi300476v  0.6
2012 Kim J, Wang L, Li Y, Becnel KD, Frey KM, Garforth SJ, Prasad VR, Schinazi RF, Liotta DC, Anderson KS. Pre-steady state kinetic analysis of cyclobutyl derivatives of 2′-deoxyadenosine 5′-triphosphate as inhibitors of HIV-1 reverse transcriptase Bioorganic and Medicinal Chemistry Letters. 22: 4064-4067. PMID 22595174 DOI: 10.1016/j.bmcl.2012.04.078  0.6
2012 Yu TY, Mok KC, Kennedy KJ, Valton J, Anderson KS, Walker GC, Taga ME. Active site residues critical for flavin binding and 5,6-dimethylbenzimidazole biosynthesis in the flavin destructase enzyme BluB. Protein Science : a Publication of the Protein Society. 21: 839-49. PMID 22528544 DOI: 10.1002/pro.2068  0.6
2012 Sohl CD, Kasiviswanathan R, Kim J, Pradere U, Schinazi RF, Copeland WC, Mitsuya H, Baba M, Anderson KS. Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase. Molecular Pharmacology. 82: 125-33. PMID 22513406 DOI: 10.1124/mol.112.078758  0.6
2012 Ekkati AR, Bollini M, Domaoal RA, Spasov KA, Anderson KS, Jorgensen WL. Discovery of dimeric inhibitors by extension into the entrance channel of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 22: 1565-8. PMID 22269110 DOI: 10.1016/j.bmcl.2011.12.132  0.6
2012 Kim J, Roberts A, Yuan H, Xiong Y, Anderson KS. Nucleocapsid protein annealing of a primer-template enhances (+)-strand DNA synthesis and fidelity by HIV-1 reverse transcriptase. Journal of Molecular Biology. 415: 866-80. PMID 22210155 DOI: 10.1016/j.jmb.2011.12.034  0.6
2012 Sohl CD, Singh K, Kasiviswanathan R, Copeland WC, Mitsuya H, Sarafianos SG, Anderson KS. Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity. Antimicrobial Agents and Chemotherapy. 56: 1630-4. PMID 22155823 DOI: 10.1128/AAC.05729-11  0.6
2011 Dermenci A, Selig PS, Domaoal RA, Spasov KA, Anderson KS, Miller SJ. Quasi-Biomimetic Ring Contraction Catalyzed by a Cysteine-Based Nucleophile: Total Synthesis of Sch-642305, Some Analogs and their Putative anti-HIV Activities. Chemical Science (Royal Society of Chemistry : 2010). 2. PMID 24179673 DOI: 10.1039/C1SC00221J  0.6
2011 Bollini M, Domaoal RA, Thakur VV, Gallardo-Macias R, Spasov KA, Anderson KS, Jorgensen WL. Computationally-guided optimization of a docking hit to yield catechol diethers as potent anti-HIV agents. Journal of Medicinal Chemistry. 54: 8582-91. PMID 22081993 DOI: 10.1021/jm201134m  0.6
2011 Jorgensen WL, Bollini M, Thakur VV, Domaoal RA, Spasov KA, Anderson KS. Efficient discovery of potent anti-HIV agents targeting the Tyr181Cys variant of HIV reverse transcriptase. Journal of the American Chemical Society. 133: 15686-96. PMID 21853995 DOI: 10.1021/ja2058583  0.6
2010 Younis Y, Hunter R, Muhanji CI, Hale I, Singh R, Bailey CM, Sullivan TJ, Anderson KS. [d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase. Bioorganic & Medicinal Chemistry. 18: 4661-73. PMID 20605472 DOI: 10.1016/j.bmc.2010.05.025  0.6
2010 Garforth SJ, Domaoal RA, Lwatula C, Landau MJ, Meyer AJ, Anderson KS, Prasad VR. K65R and K65A substitutions in HIV-1 reverse transcriptase enhance polymerase fidelity by decreasing both dNTP misinsertion and mispaired primer extension efficiencies. Journal of Molecular Biology. 401: 33-44. PMID 20538005 DOI: 10.1016/j.jmb.2010.06.001  0.6
2010 Leung CS, Zeevaart JG, Domaoal RA, Bollini M, Thakur VV, Spasov KA, Anderson KS, Jorgensen WL. Eastern extension of azoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase; cyano group alternatives. Bioorganic & Medicinal Chemistry Letters. 20: 2485-8. PMID 20304641 DOI: 10.1016/j.bmcl.2010.03.006  0.6
2010 Stumpf JD, Bailey CM, Spell D, Stillwagon M, Anderson KS, Copeland WC. mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae. Human Molecular Genetics. 19: 2123-33. PMID 20185557 DOI: 10.1093/hmg/ddq089  0.6
2010 Bailey CM, Anderson KS. A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial disease. Biochimica Et Biophysica Acta. 1804: 1213-22. PMID 20083238 DOI: 10.1016/j.bbapap.2010.01.007  0.6
2009 Parker CG, Domaoal RA, Anderson KS, Spiegel DA. An antibody-recruiting small molecule that targets HIV gp120. Journal of the American Chemical Society. 131: 16392-4. PMID 19839582 DOI: 10.1021/ja9057647  0.6
2009 Li Z, Song F, Zhuang Z, Dunaway-Mariano D, Anderson KS. Monitoring enzyme catalysis in the multimeric state: direct observation of Arthrobacter 4-hydroxybenzoyl-coenzyme A thioesterase catalytic complexes using time-resolved electrospray ionization mass spectrometry. Analytical Biochemistry. 394: 209-16. PMID 19635449 DOI: 10.1016/j.ab.2009.07.030  0.6
2009 Bautista AD, Stephens OM, Wang L, Domaoal RA, Anderson KS, Schepartz A. Identification of a beta3-peptide HIV fusion inhibitor with improved potency in live cells. Bioorganic & Medicinal Chemistry Letters. 19: 3736-8. PMID 19497744 DOI: 10.1016/j.bmcl.2009.05.032  0.6
2009 Nichols SE, Domaoal RA, Thakur VV, Tirado-Rives J, Anderson KS, Jorgensen WL. Discovery of wild-type and Y181C mutant non-nucleoside HIV-1 reverse transcriptase inhibitors using virtual screening with multiple protein structures. Journal of Chemical Information and Modeling. 49: 1272-9. PMID 19374380 DOI: 10.1021/ci900068k  0.6
2009 Bailey CM, Kasiviswanathan R, Copeland WC, Anderson KS. R964C mutation of DNA polymerase gamma imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activity. Antimicrobial Agents and Chemotherapy. 53: 2610-2. PMID 19364868 DOI: 10.1128/AAC.01659-08  0.6
2009 Lew ED, Furdui CM, Anderson KS, Schlessinger J. The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations. Science Signaling. 2: ra6. PMID 19224897 DOI: 10.1126/scisignal.2000021  0.6
2009 Dasgupta T, Chitnumsub P, Kamchonwongpaisan S, Maneeruttanarungroj C, Nichols SE, Lyons TM, Tirado-Rives J, Jorgensen WL, Yuthavong Y, Anderson KS. Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria. Acs Chemical Biology. 4: 29-40. PMID 19146480 DOI: 10.1021/cb8002804  0.6
2009 Martucci WE, Udier-Blagovic M, Atreya C, Babatunde O, Vargo MA, Jorgensen WL, Anderson KS. Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen. Bioorganic & Medicinal Chemistry Letters. 19: 418-23. PMID 19059777 DOI: 10.1016/j.bmcl.2008.11.054  0.6
2009 Vargo MA, Martucci WE, Anderson KS. Disruption of the crossover helix impairs dihydrofolate reductase activity in the bifunctional enzyme TS-DHFR from Cryptosporidium hominis. The Biochemical Journal. 417: 757-64. PMID 18851711 DOI: 10.1042/BJ20081247  0.6
2008 Hunter R, Younis Y, Muhanji CI, Curtin TL, Naidoo KJ, Petersen M, Bailey CM, Basavapathruni A, Anderson KS. C-2-aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors. Bioorganic & Medicinal Chemistry. 16: 10270-80. PMID 18996020 DOI: 10.1016/j.bmc.2008.10.048  0.6
2008 Martucci WE, Vargo MA, Anderson KS. Explaining an unusually fast parasitic enzyme: folate tail-binding residues dictate substrate positioning and catalysis in Cryptosporidium hominis thymidylate synthase. Biochemistry. 47: 8902-11. PMID 18672899 DOI: 10.1021/bi800466z  0.6
2008 Zeevaart JG, Wang L, Thakur VV, Leung CS, Tirado-Rives J, Bailey CM, Domaoal RA, Anderson KS, Jorgensen WL. Optimization of azoles as anti-human immunodeficiency virus agents guided by free-energy calculations. Journal of the American Chemical Society. 130: 9492-9. PMID 18588301 DOI: 10.1021/ja8019214  0.6
2008 Shen L, Peterson S, Sedaghat AR, McMahon MA, Callender M, Zhang H, Zhou Y, Pitt E, Anderson KS, Acosta EP, Siliciano RF. Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs. Nature Medicine. 14: 762-6. PMID 18552857 DOI: 10.1038/nm1777  0.6
2008 Domaoal RA, McMahon M, Thio CL, Bailey CM, Tirado-Rives J, Obikhod A, Detorio M, Rapp KL, Siliciano RF, Schinazi RF, Anderson KS. Pre-steady-state kinetic studies establish entecavir 5'-triphosphate as a substrate for HIV-1 reverse transcriptase. The Journal of Biological Chemistry. 283: 5452-9. PMID 17962184 DOI: 10.1074/jbc.M707834200  0.6
2007 Barreiro G, Kim JT, Guimarães CR, Bailey CM, Domaoal RA, Wang L, Anderson KS, Jorgensen WL. From docking false-positive to active anti-HIV agent. Journal of Medicinal Chemistry. 50: 5324-9. PMID 17918923 DOI: 10.1021/jm070683u  0.6
2007 Xia Q, Radzio J, Anderson KS, Sluis-Cremer N. Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses. Protein Science : a Publication of the Protein Society. 16: 1728-37. PMID 17656585 DOI: 10.1110/ps.072829007  0.6
2007 Doan LT, Martucci WE, Vargo MA, Atreya CE, Anderson KS. Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis. Biochemistry. 46: 8379-91. PMID 17580969 DOI: 10.1021/bi700531r  0.6
2007 Nakata H, Amano M, Koh Y, Kodama E, Yang G, Bailey CM, Kohgo S, Hayakawa H, Matsuoka M, Anderson KS, Cheng YC, Mitsuya H. Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine. Antimicrobial Agents and Chemotherapy. 51: 2701-8. PMID 17548498 DOI: 10.1128/AAC.00277-07  0.6
2007 Murakami E, Bao H, Basavapathruni A, Bailey CM, Du J, Steuer HM, Niu C, Whitaker T, Anderson KS, Otto MJ, Furman PA. Mechanism of action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl) thymine as an anti-HIV agent. Antiviral Chemistry & Chemotherapy. 18: 83-92. PMID 17542153  0.6
2007 Mulloy R, Ferrand A, Kim Y, Sordella R, Bell DW, Haber DA, Anderson KS, Settleman J. Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib Cancer Research. 67: 2325-2330. PMID 17332364 DOI: 10.1158/0008-5472.CAN-06-4293  0.6
2007 Hunter R, Muhanji CI, Hale I, Bailey CM, Basavapathruni A, Anderson KS. [d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor. Bioorganic & Medicinal Chemistry Letters. 17: 2614-7. PMID 17317163 DOI: 10.1016/j.bmcl.2007.01.107  0.6
2006 Kim JT, Hamilton AD, Bailey CM, Domaoal RA, Domoal RA, Wang L, Anderson KS, Jorgensen WL. FEP-guided selection of bicyclic heterocycles in lead optimization for non-nucleoside inhibitors of HIV-1 reverse transcriptase. Journal of the American Chemical Society. 128: 15372-3. PMID 17131993 DOI: 10.1021/ja066472g  0.6
2006 Massimine KM, McIntosh MT, Doan LT, Atreya CE, Gromer S, Sirawaraporn W, Elliott DA, Joiner KA, Schirmer RH, Anderson KS. Eosin B as a novel antimalarial agent for drug-resistant Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 50: 3132-41. PMID 16940112 DOI: 10.1128/AAC.00621-06  0.6
2006 Thakur VV, Kim JT, Hamilton AD, Bailey CM, Domaoal RA, Wang L, Anderson KS, Jorgensen WL. Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 16: 5664-7. PMID 16931015 DOI: 10.1016/j.bmcl.2006.08.037  0.6
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