George C. Prendergast - Publications

Lankenau Institute for Medical Research 
Cancer Research

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Metz R, Smith C, DuHadaway JB, Chandler P, Baban B, Merlo LMF, Pigott E, Keough MP, Rust S, Mellor AL, Mandik-Nayak L, Muller AJ, Prendergast GC. IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation. International Immunology. 31: 181-182. PMID 31222337 DOI: 10.1093/intimm/dxz003  0.52
2019 Thomas S, Hoxha K, Tran A, Prendergast GC. Bin1 antibody lowers the expression of phosphorylated Tau in Alzheimer's disease. Journal of Cellular Biochemistry. PMID 31211444 DOI: 10.1002/jcb.29142  0.96
2019 Manley K, Bravo-Nuevo A, Minton AR, Sedano S, Marcy A, Reichman M, Tobia A, Artlett CM, Gilmour SK, Laury-Kleintop LD, Prendergast GC. Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine. Journal of Cellular Biochemistry. PMID 30809852 DOI: 10.1002/jcb.28492  0.52
2018 Almonte-Baldonado R, Bravo-Nuevo A, Gerald D, Benjamin LE, Prendergast GC, Laury-Kleintop LD. RhoB antibody alters retinal vascularization in models of murine retinopathy. Journal of Cellular Biochemistry. PMID 30536763 DOI: 10.1002/jcb.28213  0.52
2018 Winters M, DuHadaway JB, Pham KN, Lewis-Ballester A, Badir S, Wai J, Sheikh E, Yeh SR, Prendergast GC, Muller AJ, Malachowski WP. Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase. European Journal of Medicinal Chemistry. 162: 455-464. PMID 30469041 DOI: 10.1016/j.ejmech.2018.11.010  0.52
2018 Thomas S, Hoxha K, Alexander W, Gilligan J, Dilbarova R, Whittaker K, Kossenkov A, Prendergast GC, Mullin JM. Intestinal barrier tightening by a cell-penetrating antibody to Bin1, a candidate target for immunotherapy of ulcerative colitis. Journal of Cellular Biochemistry. PMID 30269357 DOI: 10.1002/jcb.27716  0.96
2018 Nevler A, Muller AJ, Sutanto-Ward E, DuHadaway JB, Nagatomo K, Londin E, O'Hayer K, Cozzitorto JA, Lavu H, Yeo TP, Curtis MT, Villatoro T, Leiby BE, Mandik-Nayak L, Winter JM, ... ... Prendergast GC, et al. Host gene status influences tumor progression and radiotherapy response in -driven sporadic pancreatic cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30266763 DOI: 10.1158/1078-0432.CCR-18-0814  0.52
2018 Fox E, Oliver T, Rowe M, Thomas S, Zakharia Y, Gilman PB, Muller AJ, Prendergast GC. Indoximod: An Immunometabolic Adjuvant That Empowers T Cell Activity in Cancer. Frontiers in Oncology. 8: 370. PMID 30254983 DOI: 10.3389/fonc.2018.00370  0.96
2018 Muller AJ, Manfredi MG, Zakharia Y, Prendergast GC. Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond. Seminars in Immunopathology. PMID 30203227 DOI: 10.1007/s00281-018-0702-0  0.52
2018 Nevler A, Muller AJ, Cozzitorto JA, Goetz A, Winter JM, Yeo TP, Lavu H, Yeo CJ, Prendergast GC, Brody JR. A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss of Function Polymorphisms and Indoleamine-2,3-Dioxygenase-2. Journal of the American College of Surgeons. PMID 29426021 DOI: 10.1016/j.jamcollsurg.2017.12.052  0.52
2018 Prendergast GC, Malachowski WJ, Mondal A, Scherle P, Muller AJ. Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer. International Review of Cell and Molecular Biology. 336: 175-203. PMID 29413890 DOI: 10.1016/bs.ircmb.2017.07.004  0.52
2018 Prendergast GC, Mondal A, Dey S, Laury-Kleintop LD, Muller AJ. Inflammatory Reprogramming with IDO1 Inhibitors: Turning Immunologically Unresponsive 'Cold' Tumors 'Hot'. Trends in Cancer. 4: 38-58. PMID 29413421 DOI: 10.1016/j.trecan.2017.11.005  0.52
2018 Jiao X, Velasco-Velázquez MA, Wang M, Li Z, Rui H, Peck AR, Korkola JE, Chen X, Xu S, DuHadaway JB, Guerrero-Rodriguez S, Addya S, Sicoli D, Mu Z, Zhang G, ... ... Prendergast GC, et al. CCR5 governs DNA damage and breast cancer stem cell expansion. Cancer Research. PMID 29358169 DOI: 10.1158/0008-5472.CAN-17-0915  0.48
2017 Prendergast GC, Malachowski WP, DuHadaway JB, Muller AJ. Discovery of IDO1 Inhibitors: From Bench to Bedside. Cancer Research. 77: 6795-6811. PMID 29247038 DOI: 10.1158/0008-5472.CAN-17-2285  0.52
2017 Mandik-Nayak L, DuHadaway JB, Mulgrew J, Pigott E, Manley K, Sedano S, Prendergast GC, Laury-Kleintop LD. RhoB blockade selectively inhibits autoantibody production in autoimmune models of rheumatoid arthritis and lupus. Disease Models & Mechanisms. PMID 28882929 DOI: 10.1242/dmm.029835  0.48
2017 Thomas S, Izard J, Walsh E, Batich K, Chongsathidkiet P, Clarke G, Sela DA, Muller AJ, Mullin JM, Albert K, Gilligan JP, DiGuilio K, Dilbarova R, Alexander W, Prendergast GC. The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists. Cancer Research. PMID 28292977 DOI: 10.1158/0008-5472.CAN-16-2929  0.96
2017 Merlo LM, Grabler S, DuHadaway JB, Pigott E, Manley K, Prendergast GC, Laury-Kleintop LD, Mandik-Nayak L. Therapeutic antibody targeting of indoleamine-2,3-dioxygenase (IDO2) inhibits autoimmune arthritis. Clinical Immunology (Orlando, Fla.). PMID 28223071 DOI: 10.1016/j.clim.2017.01.016  0.48
2016 Mondal A, Smith C, DuHadaway JB, Sutanto-Ward E, Prendergast GC, Bravo-Nuevo A, Muller AJ. IDO1 is an Integral Mediator of Inflammatory Neovascularization. Ebiomedicine. PMID 27889479 DOI: 10.1016/j.ebiom.2016.11.013  0.52
2016 Kutner T, Kunkel E, Wang Y, George K, Zeger EL, Ali ZA, Prendergast GC, Gilman PB, Wallon UM. Preliminary evaluation of a predictive blood assay to identify patients at high risk of chemotherapy-induced nausea. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer. PMID 27734152 DOI: 10.1007/s00520-016-3442-5  0.48
2016 Merlo LM, DuHadaway JB, Grabler S, Prendergast GC, Muller AJ, Mandik-Nayak L. IDO2 Modulates T Cell-Dependent Autoimmune Responses through a B Cell-Intrinsic Mechanism. Journal of Immunology (Baltimore, Md. : 1950). PMID 27183624 DOI: 10.4049/jimmunol.1600141  0.52
2016 Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Chang MY, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T. BIN1 regulates BACE1 intracellular trafficking and amyloid-β production. Human Molecular Genetics. PMID 27179792 DOI: 10.1093/hmg/ddw146  0.52
2016 Thomas S, Prendergast GC. Cancer Vaccines: A Brief Overview. Methods in Molecular Biology (Clifton, N.J.). 1403: 755-61. PMID 27076165 DOI: 10.1007/978-1-4939-3387-7_43  1
2016 DuHadaway J, Prendergast GC. Antimetabolite TTL-315 selectively kills glucose-deprived cancer cells and enhances responses to cytotoxic chemotherapy in preclinical models of cancer. Oncotarget. 7: 7372-80. PMID 26840263 DOI: 10.18632/oncotarget.7058  0.56
2015 Malachowski WP, Winters M, DuHadaway JB, Lewis-Ballester A, Badir S, Wai J, Rahman M, Sheikh E, LaLonde JM, Yeh SR, Prendergast GC, Muller AJ. O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. European Journal of Medicinal Chemistry. 108: 564-576. PMID 26717206 DOI: 10.1016/j.ejmech.2015.12.028  1
2015 Bravo-Nuevo A, Brandli AA, Gerhart J, Nichols J, Pitts M, Sutera CK, Assali S, Scheinfeld V, Prendergast GC, Stone J, George-Weinstein M. Neuroprotective Effect of Myo/Nog Cells in the Stressed Retina. Experimental Eye Research. PMID 26688580 DOI: 10.1016/j.exer.2015.11.023  0.52
2015 Thomas S, Mercado JM, DuHadaway J, DiGuilio K, Mullin JM, Prendergast GC. Novel Colitis Immunotherapy Targets Bin1 and Improves Colon Cell Barrier Function. Digestive Diseases and Sciences. PMID 26195312 DOI: 10.1007/s10620-015-3804-8  1
2015 Laury-Kleintop LD, Mulgrew JR, Heletz I, Nedelcoviciu RA, Chang MY, Harris DM, Koch WJ, Schneider MD, Muller AJ, Prendergast GC. Cardiac-Specific Disruption of Bin1 in Mice Enables a Model of Stress- and Age-Associated Dilated Cardiomyopathy. Journal of Cellular Biochemistry. PMID 25939245 DOI: 10.1002/jcb.25198  1
2014 Prendergast GC, Metz R, Muller AJ, Merlo LM, Mandik-Nayak L. IDO2 in Immunomodulation and Autoimmune Disease. Frontiers in Immunology. 5: 585. PMID 25477879 DOI: 10.3389/fimmu.2014.00585  1
2014 Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, ... ... Prendergast GC, et al. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature. 511: 184-90. PMID 24930766 DOI: 10.1038/nature13323  1
2014 Pigott E, DuHadaway JB, Muller AJ, Gilmour S, Prendergast GC, Mandik-Nayak L. 1-Methyl-tryptophan synergizes with methotrexate to alleviate arthritis in a mouse model of arthritis. Autoimmunity. 47: 409-18. PMID 24798341 DOI: 10.3109/08916934.2014.914507  0.52
2014 Prendergast GC, Smith C, Thomas S, Mandik-Nayak L, Laury-Kleintop L, Metz R, Muller AJ. Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer. Cancer Immunology, Immunotherapy : Cii. 63: 721-35. PMID 24711084 DOI: 10.1007/s00262-014-1549-4  0.96
2014 Bravo-Nuevo A, Marcy A, Huang M, Kappler F, Mulgrew J, Laury-Kleintop L, Reichman M, Tobia A, Prendergast GC. Meglumine exerts protective effects against features of metabolic syndrome and type II diabetes. Plos One. 9: e90031. PMID 24587200 DOI: 10.1371/journal.pone.0090031  0.52
2014 Merlo LM, Pigott E, DuHadaway JB, Grabler S, Metz R, Prendergast GC, Mandik-Nayak L. IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis. Journal of Immunology (Baltimore, Md. : 1950). 192: 2082-90. PMID 24489090 DOI: 10.4049/jimmunol.1303012  1
2014 Metz R, Smith C, DuHadaway JB, Chandler P, Baban B, Merlo LM, Pigott E, Keough MP, Rust S, Mellor AL, Mandik-Nayak L, Muller AJ, Prendergast GC. IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation. International Immunology. 26: 357-67. PMID 24402311 DOI: 10.1093/intimm/dxt073  1
2014 Trabanelli S, Očadlíková D, Ciciarello M, Salvestrini V, Lecciso M, Jandus C, Metz R, Evangelisti C, Laury-Kleintop L, Romero P, Prendergast GC, Curti A, Lemoli RM. The SOCS3-independent expression of IDO2 supports the homeostatic generation of T regulatory cells by human dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 192: 1231-40. PMID 24391212 DOI: 10.4049/jimmunol.1300720  0.44
2014 Thomas S, DuHadaway J, Prendergast GC, Laury-Kleintop L. Specific in situ detection of murine indoleamine 2, 3-dioxygenase. Journal of Cellular Biochemistry. 115: 391-6. PMID 24123235 DOI: 10.1002/jcb.24674  0.96
2013 Gerald D, Adini I, Shechter S, Perruzzi C, Varnau J, Hopkins B, Kazerounian S, Kurschat P, Blachon S, Khedkar S, Bagchi M, Sherris D, Prendergast GC, Klagsbrun M, Stuhlmann H, et al. RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription. Nature Communications. 4: 2824. PMID 24280686 DOI: 10.1038/ncomms3824  1
2013 Eldredge HB, Denittis A, Duhadaway JB, Chernick M, Metz R, Prendergast GC. CONCURRENT WHOLE BRAIN RADIOTHERAPY AND SHORT-COURSE CHLOROQUINE IN PATIENTS WITH BRAIN METASTASES: A PILOT TRIAL. Journal of Radiation Oncology. 2. PMID 24187608 DOI: 10.1007/s13566-013-0111-x  0.48
2013 Sawyers CL, Abate-Shen C, Anderson KC, Barker A, Baselga J, Berger NA, Foti M, Jemal A, Lawrence TS, Li CI, Mardis ER, Neumann PJ, Pardoll DM, Prendergast GC, et al. AACR Cancer Progress Report 2013. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: S4-98. PMID 24045178 DOI: 10.1158/1078-0432.CCR-13-2107  1
2013 Simionescu-Bankston A, Leoni G, Wang Y, Pham PP, Ramalingam A, DuHadaway JB, Faundez V, Nusrat A, Prendergast GC, Pavlath GK. The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis. Developmental Biology. 382: 160-71. PMID 23872330 DOI: 10.1016/j.ydbio.2013.07.004  1
2013 Kazerounian S, Gerald D, Huang M, Chin YR, Udayakumar D, Zheng N, O'Donnell RK, Perruzzi C, Mangiante L, Pourat J, Phung TL, Bravo-Nuevo A, Shechter S, McNamara S, Duhadaway JB, ... ... Prendergast GC, et al. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Research. 73: 50-61. PMID 23135917 DOI: 10.1158/0008-5472.CAN-11-3055  1
2012 Metz R, Rust S, Duhadaway JB, Mautino MR, Munn DH, Vahanian NN, Link CJ, Prendergast GC. IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan. Oncoimmunology. 1: 1460-1468. PMID 23264892 DOI: 10.4161/onci.21716  1
2012 Janson C, Kasahara N, Prendergast GC, Colicelli J. RIN3 is a negative regulator of mast cell responses to SCF. Plos One. 7: e49615. PMID 23185384 DOI: 10.1371/journal.pone.0049615  1
2012 Smith C, Chang MY, Parker KH, Beury DW, DuHadaway JB, Flick HE, Boulden J, Sutanto-Ward E, Soler AP, Laury-Kleintop LD, Mandik-Nayak L, Metz R, Ostrand-Rosenberg S, Prendergast GC, Muller AJ. IDO is a nodal pathogenic driver of lung cancer and metastasis development. Cancer Discovery. 2: 722-35. PMID 22822050 DOI: 10.1158/2159-8290.CD-12-0014  1
2012 Wojciak-Stothard B, Zhao L, Oliver E, Dubois O, Wu Y, Kardassis D, Vasilaki E, Huang M, Mitchell JA, Harrington LS, Louise H, Prendergast GC, Wilkins MR. Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia. Circulation Research. 110: 1423-34. PMID 22539766 DOI: 10.1161/CIRCRESAHA.112.264473  1
2012 Chang MY, Boulden J, Valenzano MC, Soler AP, Muller AJ, Mullin JM, Prendergast GC. Bin1 attenuation suppresses experimental colitis by enforcing intestinal barrier function. Digestive Diseases and Sciences. 57: 1813-21. PMID 22526583 DOI: 10.1007/s10620-012-2147-y  1
2012 Divanovic S, Sawtell NM, Trompette A, Warning JI, Dias A, Cooper AM, Yap GS, Arditi M, Shimada K, Duhadaway JB, Prendergast GC, Basaraba RJ, Mellor AL, Munn DH, Aliberti J, et al. Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. The Journal of Infectious Diseases. 205: 152-61. PMID 21990421 DOI: 10.1093/infdis/jir621  1
2011 Chang MY, Smith C, DuHadaway JB, Pyle JR, Boulden J, Soler AP, Muller AJ, Laury-Kleintop LD, Prendergast GC. Cardiac and gastrointestinal liabilities caused by deficiency in the immune modulatory enzyme indoleamine 2,3-dioxygenase. Cancer Biology & Therapy. 12: 1050-8. PMID 22157149 DOI: 10.4161/cbt.12.12.18142  0.52
2011 Barberan S, McNair K, Iqbal K, Smith NC, Prendergast GC, Stone TW, Cobb SR, Morris BJ. Altered apoptotic responses in neurons lacking RhoB GTPase. The European Journal of Neuroscience. 34: 1737-46. PMID 22098422 DOI: 10.1111/j.1460-9568.2011.07891.x  1
2011 Ha NH, Nair VS, Reddy DN, Mudvari P, Ohshiro K, Ghanta KS, Pakala SB, Li DQ, Costa L, Lipton A, Badwe RA, Fuqua S, Wallon M, Prendergast GC, Kumar R. Lactoferrin-endothelin-1 axis contributes to the development and invasiveness of triple-negative breast cancer phenotypes. Cancer Research. 71: 7259-69. PMID 22006997 DOI: 10.1158/0008-5472.CAN-11-1143  1
2011 Zhang C, Elkahloun AG, Liao H, Delaney S, Saber B, Morrow B, Prendergast GC, Hollander MC, Gills JJ, Dennis PA. Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells. Molecular Cancer Therapeutics. 10: 1137-48. PMID 21551261 DOI: 10.1158/1535-7163.MCT-10-1028  1
2011 Huang M, Satchell L, Duhadaway JB, Prendergast GC, Laury-Kleintop LD. RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac. Journal of Cellular Biochemistry. 112: 1572-84. PMID 21344485 DOI: 10.1002/jcb.23069  0.48
2011 Bravo-Nuevo A, Sugimoto H, Iyer S, Fallon Z, Lucas JM, Kazerounian S, Prendergast GC, Kalluri R, Shapiro NI, Benjamin LE. RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice. The American Journal of Pathology. 178: 245-52. PMID 21224061 DOI: 10.1016/j.ajpath.2010.11.040  1
2010 Tian L, Huang K, DuHadaway JB, Prendergast GC, Stambolian D. Genomic profiling of miRNAs in two human lens cell lines. Current Eye Research. 35: 812-8. PMID 20795863 DOI: 10.3109/02713683.2010.489182  0.48
2010 Muller AJ, DuHadaway JB, Chang MY, Ramalingam A, Sutanto-Ward E, Boulden J, Soler AP, Mandik-Nayak L, Gilmour SK, Prendergast GC. Non-hematopoietic expression of IDO is integrally required for inflammatory tumor promotion. Cancer Immunology, Immunotherapy : Cii. 59: 1655-63. PMID 20640572 DOI: 10.1007/s00262-010-0891-4  1
2010 Muller AJ, Mandik-Nayak L, Prendergast GC. Beyond immunosuppression: reconsidering indoleamine 2,3-dioxygenase as a pathogenic element of chronic inflammation. Immunotherapy. 2: 293-7. PMID 20635895 DOI: 10.2217/imt.10.22  1
2010 Donover PS, Wojciechowski BS, Thirumaran R, Zemba-Palko V, Prendergast GC, Wallon UM. Development of a monoclonal antibody that specifically detects tissue inhibitor of metalloproteinase-4 (TIMP-4) in formalin-fixed, paraffin-embedded human tissues. Journal of Cellular Biochemistry. 110: 1255-61. PMID 20564221 DOI: 10.1002/jcb.22641  0.36
2010 Metz R, Duhadaway JB, Rust S, Munn DH, Muller AJ, Mautino M, Prendergast GC. Zinc protoporphyrin IX stimulates tumor immunity by disrupting the immunosuppressive enzyme indoleamine 2,3-dioxygenase. Molecular Cancer Therapeutics. 9: 1864-71. PMID 20530717 DOI: 10.1158/1535-7163.MCT-10-0185  0.52
2010 Prendergast GC, Metz R, Muller AJ. Towards a genetic definition of cancer-associated inflammation: role of the IDO pathway. The American Journal of Pathology. 176: 2082-7. PMID 20228228 DOI: 10.2353/ajpath.2010.091173  1
2010 McNair K, Spike R, Guilding C, Prendergast GC, Stone TW, Cobb SR, Morris BJ. A role for RhoB in synaptic plasticity and the regulation of neuronal morphology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3508-17. PMID 20203211 DOI: 10.1523/JNEUROSCI.5386-09.2010  1
2010 Muller AJ, DuHadaway JB, Jaller D, Curtis P, Metz R, Prendergast GC. Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate. Cancer Research. 70: 1845-53. PMID 20160032 DOI: 10.1158/0008-5472.CAN-09-3613  0.52
2009 DeWard AD, Leali K, West RA, Prendergast GC, Alberts AS. Loss of RhoB expression enhances the myelodysplastic phenotype of mammalian diaphanous-related Formin mDia1 knockout mice. Plos One. 4: e7102. PMID 19768111 DOI: 10.1371/journal.pone.0007102  1
2009 Liss M, Sreedhar N, Keshgegian A, Sauter G, Chernick MR, Prendergast GC, Wallon UM. Tissue inhibitor of metalloproteinase-4 is elevated in early-stage breast cancers with accelerated progression and poor clinical course. The American Journal of Pathology. 175: 940-6. PMID 19700750 DOI: 10.2353/ajpath.2009.081094  0.36
2009 Scott GN, DuHadaway J, Pigott E, Ridge N, Prendergast GC, Muller AJ, Mandik-Nayak L. The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 182: 7509-17. PMID 19494274 DOI: 10.4049/jimmunol.0804328  0.56
2009 Witkiewicz AK, Costantino CL, Metz R, Muller AJ, Prendergast GC, Yeo CJ, Brody JR. Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. Journal of the American College of Surgeons. 208: 781-7; discussion 78. PMID 19476837 DOI: 10.1016/j.jamcollsurg.2008.12.018  1
2009 Prendergast GC, Metz R, Muller AJ. IDO recruits Tregs in melanoma. Cell Cycle (Georgetown, Tex.). 8: 1818-9. PMID 19471123  1
2009 Prendergast GC, Muller AJ, Ramalingam A, Chang MY. BAR the door: cancer suppression by amphiphysin-like genes. Biochimica Et Biophysica Acta. 1795: 25-36. PMID 18930786 DOI: 10.1016/j.bbcan.2008.09.001  1
2008 Muller AJ, Sharma MD, Chandler PR, Duhadaway JB, Everhart ME, Johnson BA, Kahler DJ, Pihkala J, Soler AP, Munn DH, Prendergast GC, Mellor AL. Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase. Proceedings of the National Academy of Sciences of the United States of America. 105: 17073-8. PMID 18952840 DOI: 10.1073/pnas.0806173105  0.52
2008 Kumar S, Jaller D, Patel B, LaLonde JM, DuHadaway JB, Malachowski WP, Prendergast GC, Muller AJ. Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase Journal of Medicinal Chemistry. 51: 4968-4977. PMID 18665584 DOI: 10.1021/jm800512z  1
2008 Katz JB, Muller AJ, Prendergast GC. Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunological Reviews. 222: 206-21. PMID 18364004 DOI: 10.1111/j.1600-065X.2008.00610.x  1
2008 Ramalingam A, Duhadaway JB, Sutanto-Ward E, Wang Y, Dinchuk J, Huang M, Donover PS, Boulden J, McNally LM, Soler AP, Muller AJ, Duncan MK, Prendergast GC. Bin3 deletion causes cataracts and increased susceptibility to lymphoma during aging. Cancer Research. 68: 1683-90. PMID 18339847 DOI: 10.1158/0008-5472.CAN-07-6072  1
2008 Kumar S, Malachowski WP, DuHadaway JB, LaLonde JM, Carroll PJ, Jaller D, Metz R, Prendergast GC, Muller AJ. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. Journal of Medicinal Chemistry. 51: 1706-18. PMID 18318466 DOI: 10.1021/jm7014155  1
2008 Li Z, Wang C, Jiao X, Katiyar S, Casimiro MC, Prendergast GC, Powell MJ, Pestell RG. Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration. The Journal of Biological Chemistry. 283: 7007-15. PMID 18180298 DOI: 10.1074/jbc.M706992200  1
2007 Huang M, Duhadaway JB, Prendergast GC, Laury-Kleintop LD. RhoB regulates PDGFR-beta trafficking and signaling in vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 2597-605. PMID 17951322 DOI: 10.1161/ATVBAHA.107.154211  0.48
2007 Kamasani U, Duhadaway JB, Alberts AS, Prendergast GC. mDia function is critical for the cell suicide program triggered by farnesyl transferase inhibition. Cancer Biology & Therapy. 6: 1422-7. PMID 17786040  1
2007 Chang MY, Boulden J, Katz JB, Wang L, Meyer TJ, Soler AP, Muller AJ, Prendergast GC. Bin1 ablation increases susceptibility to cancer during aging, particularly lung cancer. Cancer Research. 67: 7605-12. PMID 17699764 DOI: 10.1158/0008-5472.CAN-07-1100  1
2007 Ramalingam A, Farmer GE, Stamato TD, Prendergast GC. Bin1 interacts with and restrains the DNA end-binding protein complex Ku. Cell Cycle (Georgetown, Tex.). 6: 1914-8. PMID 17671430  1
2007 Metz R, Duhadaway JB, Kamasani U, Laury-Kleintop L, Muller AJ, Prendergast GC. Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Cancer Research. 67: 7082-7. PMID 17671174 DOI: 10.1158/0008-5472.CAN-07-1872  0.52
2007 Ramalingam A, Prendergast GC. Bin1 homolog hob1 supports a Rad6-Set1 pathway of transcriptional repression in fission yeast. Cell Cycle (Georgetown, Tex.). 6: 1655-62. PMID 17611416 DOI: 10.4161/cc.6.13.4413  1
2007 Muller AJ, Prendergast GC. Indoleamine 2,3-dioxygenase in immune suppression and cancer. Current Cancer Drug Targets. 7: 31-40. PMID 17305476 DOI: 10.2174/156800907780006896  1
2007 Hou DY, Muller AJ, Sharma MD, DuHadaway J, Banerjee T, Johnson M, Mellor AL, Prendergast GC, Munn DH. Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. Cancer Research. 67: 792-801. PMID 17234791 DOI: 10.1158/0008-5472.CAN-06-2925  0.56
2007 Ghaneie A, Zemba-Palko V, Itoh H, Itoh K, Sakamuro D, Nakamura S, Soler AP, Prendergast GC. Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival. Cancer Biology & Therapy. 6: 192-4. PMID 17218774  1
2007 Chang MY, Boulden J, Sutanto-Ward E, Duhadaway JB, Soler AP, Muller AJ, Prendergast GC. Bin1 ablation in mammary gland delays tissue remodeling and drives cancer progression. Cancer Research. 67: 100-7. PMID 17210688 DOI: 10.1158/0008-5472.CAN-06-2742  0.52
2006 Li Z, Wang C, Prendergast GC, Pestell RG. Cyclin D1 functions in cell migration. Cell Cycle (Georgetown, Tex.). 5: 2440-2. PMID 17106256 DOI: 10.4161/cc.5.21.3428  1
2006 Casal E, Federici L, Zhang W, Fernandez-Recio J, Priego EM, Miguel RN, DuHadaway JB, Prendergast GC, Luisi BF, Laue ED. The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition. Biochemistry. 45: 12917-28. PMID 17059209 DOI: 10.1021/bi060717k  0.48
2006 Gaspari P, Banerjee T, Malachowski WP, Muller AJ, Prendergast GC, DuHadaway J, Bennett S, Donovan AM. Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. Journal of Medicinal Chemistry. 49: 684-92. PMID 16420054 DOI: 10.1021/jm0508888  1
2005 Muller AJ, Prendergast GC. Marrying immunotherapy with chemotherapy: why say IDO? Cancer Research. 65: 8065-8. PMID 16166276 DOI: 10.1158/0008-5472.CAN-05-2213  1
2005 Masumi A, Aizaki H, Suzuki T, DuHadaway JB, Prendergast GC, Komuro K, Fukazawa H. Reduction of hepatitis C virus NS5A phosphorylation through its interaction with amphiphysin II. Biochemical and Biophysical Research Communications. 336: 572-8. PMID 16139795 DOI: 10.1016/j.bbrc.2005.08.142  0.48
2005 Muller AJ, Malachowski WP, Prendergast GC. Indoleamine 2,3-dioxygenase in cancer: targeting pathological immune tolerance with small-molecule inhibitors. Expert Opinion On Therapeutic Targets. 9: 831-49. PMID 16083346 DOI: 10.1517/14728222.9.4.831  1
2005 Kamasani U, Prendergast GC. Genetic response to DNA damage: proapoptotic targets of RhoB include modules for p53 response and susceptibility to Alzheimer's disease. Cancer Biology & Therapy. 4: 282-8. PMID 15876868  0.44
2005 Muller AJ, DuHadaway JB, Donover PS, Sutanto-Ward E, Prendergast GC. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nature Medicine. 11: 312-9. PMID 15711557 DOI: 10.1038/nm1196  0.52
2004 Muller AJ, DuHadaway JB, Donover PS, Sutanto-Ward E, Prendergast GC. Targeted deletion of the suppressor gene bin1/amphiphysin2 accentuates the neoplastic character of transformed mouse fibroblasts. Cancer Biology & Therapy. 3: 1236-42. PMID 15611650  0.52
2004 Sandilands E, Cans C, Fincham VJ, Brunton VG, Mellor H, Prendergast GC, Norman JC, Superti-Furga G, Frame MC. RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Developmental Cell. 7: 855-69. PMID 15572128 DOI: 10.1016/j.devcel.2004.09.019  1
2004 Kamasani U, Huang M, Duhadaway JB, Prochownik EV, Donover PS, Prendergast GC. Cyclin B1 is a critical target of RhoB in the cell suicide program triggered by farnesyl transferase inhibition. Cancer Research. 64: 8389-96. PMID 15548709 DOI: 10.1158/0008-5472.CAN-04-2437  0.48
2003 Adini I, Rabinovitz I, Sun JF, Prendergast GC, Benjamin LE. RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. Genes & Development. 17: 2721-32. PMID 14597666 DOI: 10.1101/gad.1134603  0.52
2003 Kamasani U, Liu AX, Prendergast GC. Genetic response to farnesyltransferase inhibitors: proapoptotic targets of RhoB. Cancer Biology & Therapy. 2: 273-80. PMID 12878865  0.44
2003 DuHadaway JB, Du W, Donover S, Baker J, Liu AX, Sharp DM, Muller AJ, Prendergast GC. Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1. Oncogene. 22: 3578-88. PMID 12789266 DOI: 10.1038/sj.onc.1206481  1
2003 Muller AJ, Baker JF, DuHadaway JB, Ge K, Farmer G, Donover PS, Meade R, Reid C, Grzanna R, Roach AH, Shah N, Soler AP, Prendergast GC. Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation. Molecular and Cellular Biology. 23: 4295-306. PMID 12773571 DOI: 10.1128/MCB.23.12.4295-4306.2003  1
2003 Zeng PY, Rane N, Du W, Chintapalli J, Prendergast GC. Role for RhoB and PRK in the suppression of epithelial cell transformation by farnesyltransferase inhibitors. Oncogene. 22: 1124-34. PMID 12606940 DOI: 10.1038/sj.onc.1206181  0.48
2003 Routhier EL, Donover PS, Prendergast GC. hob1+, the fission yeast homolog of Bin1, is dispensable for endocytosis or actin organization, but required for the response to starvation or genotoxic stress. Oncogene. 22: 637-48. PMID 12569356 DOI: 10.1038/sj.onc.1206162  0.36
2003 DuHadaway JB, Lynch FJ, Brisbay S, Bueso-Ramos C, Troncoso P, McDonnell T, Prendergast GC. Immunohistochemical analysis of Bin1/Amphiphysin II in human tissues: diverse sites of nuclear expression and losses in prostate cancer. Journal of Cellular Biochemistry. 88: 635-42. PMID 12532338 DOI: 10.1002/jcb.10380  0.48
2002 van Golen KL, Bao L, DiVito MM, Wu Z, Prendergast GC, Merajver SD. Reversion of RhoC GTPase-induced inflammatory breast cancer phenotype by treatment with a farnesyl transferase inhibitor. Molecular Cancer Therapeutics. 1: 575-83. PMID 12479217  1
2001 Liu AX, Rane N, Liu JP, Prendergast GC. RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells. Molecular and Cellular Biology. 21: 6906-12. PMID 11564874 DOI: 10.1128/MCB.21.20.6906-6912.2001  0.44
2001 DuHadaway JB, Sakamuro D, Ewert DL, Prendergast GC. Bin1 mediates apoptosis by c-Myc in transformed primary cells. Cancer Research. 61: 3151-6. PMID 11306501  1
2001 Routhier EL, Burn TC, Abbaszade I, Summers M, Albright CF, Prendergast GC. Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p. The Journal of Biological Chemistry. 276: 21670-7. PMID 11274158 DOI: 10.1074/jbc.M101096200  1
2000 Elliott K, Ge K, Du W, Prendergast GC. The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program. Oncogene. 19: 4669-84. PMID 11032017 DOI: 10.1038/sj.onc.1203681  0.96
2000 Liu Ax, Du W, Liu JP, Jessell TM, Prendergast GC. RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors. Molecular and Cellular Biology. 20: 6105-13. PMID 10913192 DOI: 10.1128/MCB.20.16.6105-6113.2000  1
2000 Ge K, Prendergast GC. Bin2, a functionally nonredundant member of the BAR adaptor gene family. Genomics. 67: 210-20. PMID 10903846 DOI: 10.1006/geno.2000.6216  0.96
2000 Ge K, Minhas F, Duhadaway J, Mao NC, Wilson D, Buccafusca R, Sakamuro D, Nelson P, Malkowicz SB, Tomaszewski J, Prendergast GC. Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma. International Journal of Cancer. 86: 155-61. PMID 10738240 DOI: 10.1002/(SICI)1097-0215(20000415)86:2<155::AID-IJC2>3.0.CO;2-M  1
2000 Ge K, Duhadaway J, Sakamuro D, Wechsler-Reya R, Reynolds C, Prendergast GC. Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity International Journal of Cancer. 85: 376-383. PMID 10652430 DOI: 10.1002/(SICI)1097-0215(20000201)85:3<376::AID-IJC14>3.0.CO;2-1  1
1999 Prendergast GC, Du W. Targeting farnesyltransferase: is Ras relevant? Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 2: 81-84. PMID 11504474 DOI: 10.1054/drup.1999.0070  1
1999 Ge K, DuHadaway J, Du W, Herlyn M, Rodeck U, Prendergast GC. Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma. Proceedings of the National Academy of Sciences of the United States of America. 96: 9689-94. PMID 10449755  0.96
1999 Elliott K, Sakamuro D, Basu A, Du W, Wunner W, Staller P, Gaubatz S, Zhang H, Prochownik E, Eilers M, Prendergast GC. Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms. Oncogene. 18: 3564-73. PMID 10380878 DOI: 10.1038/sj.onc.1202670  1
1999 Sakamuro D, Prendergast GC. New Myc-interacting proteins: a second Myc network emerges. Oncogene. 18: 2942-54. PMID 10378691 DOI: 10.1038/sj.onc.1202725  1
1999 Du W, Lebowitz PF, Prendergast GC. Elevation of alpha2(I) collagen, a suppressor of Ras transformation, is required for stable phenotypic reversion by farnesyltransferase inhibitors. Cancer Research. 59: 2059-63. PMID 10232587  0.84
1999 Du W, Lebowitz PF, Prendergast GC. Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Molecular and Cellular Biology. 19: 1831-40. PMID 10022870  0.84
1998 Lebowitz PF, Prendergast GC. Functional interaction between RhoB and the transcription factor DB1. Cell Adhesion and Communication. 6: 277-87. PMID 9865462  0.84
1998 Lebowitz PF, Prendergast GC. Non-Ras targets of farnesyltransferase inhibitors: focus on Rho. Oncogene. 17: 1439-45. PMID 9779989 DOI: 10.1038/sj.onc.1202175  0.84
1998 Wechsler-Reya RJ, Elliott KJ, Prendergast GC. A role for the putative tumor suppressor Bin1 in muscle cell differentiation. Molecular and Cellular Biology. 18: 566-75. PMID 9418903  1
1997 Wechsler-Reya R, Sakamuro D, Zhang J, Duhadaway J, Prendergast GC. Structural analysis of the human BIN1 gene: Evidence for tissue-specific transcriptional regulation and alternate RNA splicing Journal of Biological Chemistry. 272: 31453-31458. PMID 9395479 DOI: 10.1074/jbc.272.50.31453  1
1997 Sakamuro D, Sabbatini P, White E, Prendergast GC. The polyproline region of p53 is required to activate apoptosis but not growth arrest. Oncogene. 15: 887-98. PMID 9285684 DOI: 10.1038/sj.onc.1201263  1
1997 Lebowitz PF, Du W, Prendergast GC. Prenylation of RhoB is required for its cell transforming function but not its ability to activate serum response element-dependent transcription. The Journal of Biological Chemistry. 272: 16093-5. PMID 9195903  0.84
1997 Lebowitz PF, Casey PJ, Prendergast GC, Thissen JA. Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB. The Journal of Biological Chemistry. 272: 15591-4. PMID 9188444 DOI: 10.1074/jbc.272.25.15591  1
1997 Lebowitz PF, Sakamuro D, Prendergast GC. Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment. Cancer Research. 57: 708-13. PMID 9044849  1
1996 Sakamuro D, Elliott KJ, Wechsler-Reya R, Prendergast GC. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor Nature Genetics. 14: 69-77. PMID 8782822 DOI: 10.1038/ng0996-69  1
1996 Negorev D, Riethman H, Wechsler-Reya R, Sakamuro D, Prendergast GC, Simon D. The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization Genomics. 33: 329-331. PMID 8725406 DOI: 10.1006/geno.1996.0205  1
1996 Negorev D, Riethman H, Wechsler-Reya R, Sakamuro D, Prendergast GC, Simon D. The Bin1 Gene Localizes to Human Chromosome 2q14 by PCR Analysis of Somatic Cell Hybrids and Fluorescence in Situ Hybridization Genomics. 33: 329-31. PMID 8660989  1
1996 Prendergast GC, Davide JP, Lebowitz PF, Wechsler-Reya R, Kohl NE. Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors Cancer Research. 56: 2626-2632. PMID 8653708  1
1995 Sakamuro D, Eviner V, Elliott KJ, Showe L, White E, Prendergast GC. c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms Oncogene. 11: 2410-2418. PMID 8570193  1
1995 Lebowitz PF, Davide JP, Prendergast GC. Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity. Molecular and Cellular Biology. 15: 6613-22. PMID 8524226  0.84
1995 Prendergast GC, Khosravi-Far R, Solski PA, Kurzawa H, Lebowitz PF, Der CJ. Critical role of Rho in cell transformation by oncogenic Ras. Oncogene. 10: 2289-96. PMID 7784077  1
1993 Ferré-D'Amaré AR, Prendergast GC, Ziff EB, Burley SK. Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain. Nature. 363: 38-45. PMID 8479534 DOI: 10.1038/363038a0  1
1992 Prendergast GC, Ziff EB. A new bind for Myc. Trends in Genetics : Tig. 8: 91-6. PMID 1579994 DOI: 10.1016/0168-9525(92)90196-B  1
1992 Prendergast GC, Hopewell R, Gorham BJ, Ziff EB. Biphasic effect of Max on Myc cotransformation activity and dependence on amino- and carboxy-terminal Max functions. Genes & Development. 6: 2429-39. PMID 1459463  1
1991 Prendergast GC, Ziff EB. Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region. Science (New York, N.Y.). 251: 186-9. PMID 1987636  1
1991 Prendergast GC, Ziff EB. Mbh 1: a novel gelsolin/severin-related protein which binds actin in vitro and exhibits nuclear localization in vivo. The Embo Journal. 10: 757-66. PMID 1849072  1
1991 Prendergast GC, Lawe D, Ziff EB. Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation. Cell. 65: 395-407. PMID 1840505 DOI: 10.1016/0092-8674(91)90457-A  1
1990 Prendergast GC, Diamond LE, Dahl D, Cole MD. The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1. Molecular and Cellular Biology. 10: 1265-9. PMID 2406566  1
1989 Prendergast GC, Ziff EB. DNA-binding motif. Nature. 341: 392. PMID 2507924 DOI: 10.1038/341392a0  1
1989 Prendergast GC, Cole MD. Posttranscriptional regulation of cellular gene expression by the c-myc oncogene. Molecular and Cellular Biology. 9: 124-34. PMID 2467185  1
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