cached image

Peter J. Sadler, Ph.D. - Publications

Affiliations: 
University of Warwick, Coventry, England, United Kingdom 
Website:
http://www2.warwick.ac.uk/fac/sci/chemistry/research/sadler/

284 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Farley SJ, Salassa L, Pizarro AM, Sadler PJ. Photoactive Platinum(II) Azopyridine Complexes. Photochemistry and Photobiology. PMID 33616206 DOI: 10.1111/php.13405  0.44
2020 Zhang WY, Banerjee S, Imberti C, Clarkson GJ, Wang Q, Zhong Q, Young LS, Romero-Canelón I, Zeng M, Habtemariam A, Sadler PJ. Strategies for conjugating iridium(III) anticancer complexes to targeting peptides via copper-free click chemistry. Inorganica Chimica Acta. 503: 119396. PMID 33776131 DOI: 10.1016/j.ica.2019.119396  0.4
2020 Donnelly JM, Lermyte F, Wolny JA, Walker M, Breeze BG, Needham RJ, Müller CS, O'Connor PB, Schünemann V, Collingwood JF, Sadler PJ. Cu(III)-bis-thiolato complex forms an unusual mono-thiolato Cu(III)-peroxido adduct. Chemical Communications (Cambridge, England). PMID 33337460 DOI: 10.1039/d0cc06921c  0.4
2020 Needham RJ, Bridgewater HE, Romero-Canelón I, Habtemariam A, Clarkson GJ, Sadler PJ. Structure-activity relationships for osmium(II) arene phenylazopyridine anticancer complexes functionalised with alkoxy and glycolic substituents. Journal of Inorganic Biochemistry. 210: 111154. PMID 32771772 DOI: 10.1016/j.jinorgbio.2020.111154  0.4
2020 Everett J, Brooks J, Lermyte F, O'Connor PB, Sadler PJ, Dobson J, Collingwood JF, Telling ND. Iron stored in ferritin is chemically reduced in the presence of aggregating Aβ(1-42). Scientific Reports. 10: 10332. PMID 32587293 DOI: 10.1038/s41598-020-67117-z  0.4
2020 Brooks J, Everett J, Lermyte F, Tjhin VT, Banerjee S, O'Connor PB, Morris CM, Sadler PJ, Telling ND, Collingwood JF. Label-free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy. Angewandte Chemie (International Ed. in English). PMID 32227670 DOI: 10.1002/anie.202000239  0.4
2020 Chiu C, Lam PYY, Wootton C, Barrow MP, Sadler PJ, O'Connor PB. Metallocomplex-Peptide Interactions Studied by Ultra-High Resolution Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 31967804 DOI: 10.1021/jasms.9b00054  0.4
2019 Lermyte F, Everett J, Lam YPY, Wootton CA, Brooks J, Barrow MP, Telling ND, Sadler PJ, O'Connor PB, Collingwood JF. Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry. Journal of the American Society For Mass Spectrometry. 30: 2123-2134. PMID 31951717 DOI: 10.1021/jasms.8b06229  0.4
2019 Shaili E, Salassa L, Woods JA, Clarkson G, Sadler PJ, Farrer NJ. Platinum(iv) dihydroxido diazido -(heterocyclic)imine complexes are potently photocytotoxic when irradiated with visible light. Chemical Science. 10: 8610-8617. PMID 31803436 DOI: 10.1039/c9sc02644d  0.44
2019 Zhang X, Ponte F, Borfecchia E, Martini A, Sanchez-Cano C, Sicilia E, Sadler PJ. Glutathione activation of an organometallic half-sandwich anticancer drug candidate by ligand attack. Chemical Communications (Cambridge, England). PMID 31742266 DOI: 10.1039/c9cc06725f  0.4
2019 Lermyte F, Everett J, Brooks J, Bellingeri F, Billimoria K, Sadler PJ, O'Connor PB, Telling ND, Collingwood JF. Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies. Cells. 8. PMID 31658742 DOI: 10.3390/cells8101231  0.4
2019 Huang H, Banerjee S, Qiu K, Zhang P, Blacque O, Malcomson T, Paterson MJ, Clarkson GJ, Staniforth M, Stavros VG, Gasser G, Chao H, Sadler PJ. Targeted photoredox catalysis in cancer cells. Nature Chemistry. PMID 31548671 DOI: 10.1038/s41557-019-0328-4  0.36
2019 Lermyte F, Everett J, Lam YPY, Wootton CA, Brooks J, Barrow MP, Telling ND, Sadler PJ, O'Connor PB, Collingwood JF. Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 31350722 DOI: 10.1007/s13361-019-02283-7  0.4
2019 Banerjee S, Omlor A, Wolny JA, Han Y, Lermyte F, Godfrey AE, O'Connor PB, Schünemann V, Danaie M, Sadler PJ. Generation of maghemite nanocrystals from iron-sulfur centres. Dalton Transactions (Cambridge, England : 2003). PMID 30951079 DOI: 10.1039/c9dt00514e  0.4
2019 Wootton CA, Millett AJ, Lopez-Clavijo AF, Chiu CKC, Barrow MP, Clarkson GJ, Sadler PJ, O'Connor PB. Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation. The Analyst. PMID 30663751 DOI: 10.1039/c8an02094a  0.4
2018 Shi H, Romero-Canelón I, Hreusova M, Novakova O, Venkatesh V, Habtemariam A, Clarkson GJ, Song JI, Brabec V, Sadler PJ. Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs. Inorganic Chemistry. PMID 30365308 DOI: 10.1021/acs.inorgchem.8b02599  0.4
2018 Coverdale JPC, Bridgewater HE, Song JI, Smith NA, Barry NPE, Bagley I, Sadler PJ, Romero Canelon I. In vivo selectivity and localization of reactive oxygen species (ROS) induction by osmium anticancer complexes that circumvent platinum-resistance. Journal of Medicinal Chemistry. PMID 30230827 DOI: 10.1021/acs.jmedchem.8b00958  0.48
2018 Chen F, Romero-Canelón I, Soldevila-Barreda JJ, Song JI, Coverdale JPC, Clarkson GJ, Kasparkova J, Habtemariam A, Wills M, Brabec V, Sadler PJ. Transfer Hydrogenation and Antiproliferative Activity of Tethered Half-Sandwich Organoruthenium Catalysts. Organometallics. 37: 1555-1566. PMID 29887657 DOI: 10.1021/acs.organomet.8b00132  0.4
2018 Martin EM, Kondrat FDL, Stewart AJ, Scrivens JH, Sadler PJ, Blindauer CA. Native electrospray mass spectrometry approaches to probe the interaction between zinc and an anti-angiogenic peptide from histidine-rich glycoprotein. Scientific Reports. 8: 8646. PMID 29872214 DOI: 10.1038/s41598-018-26924-1  0.4
2018 Banerjee S, Soldevila-Barreda JJ, Wolny JA, Wootton CA, Habtemariam A, Romero-Canelón I, Chen F, Clarkson GJ, Prokes I, Song L, O'Connor PB, Schünemann V, Sadler PJ. New activation mechanism for half-sandwich organometallic anticancer complexes. Chemical Science. 9: 3177-3185. PMID 29732100 DOI: 10.1039/c7sc05058e  0.4
2018 Wootton CA, Sanchez-Cano C, Lopez-Clavijo AF, Shaili E, Barrow MP, Sadler PJ, O'Connor PB. Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes. Chemical Science. 9: 2733-2739. PMID 29732057 DOI: 10.1039/c7sc05135b  0.4
2018 Sanchez-Cano C, Romero-Canelón I, Geraki K, Sadler PJ. Microfocus x-ray fluorescence mapping of tumour penetration by an organo‑osmium anticancer complex. Journal of Inorganic Biochemistry. 185: 26-29. PMID 29730234 DOI: 10.1016/j.jinorgbio.2018.04.014  0.36
2018 Gatti A, Habtemariam A, Romero-Canelón I, Song JI, Heer B, Clarkson GJ, Rogolino D, Sadler PJ, Carcelli M. Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative Activity. Organometallics. 37: 891-899. PMID 29681675 DOI: 10.1021/acs.organomet.7b00875  0.4
2018 Chen F, Soldevila-Barreda JJ, Romero-Canelón I, Coverdale JPC, Song JI, Clarkson GJ, Kasparkova J, Habtemariam A, Brabec V, Wolny JA, Schünemann V, Sadler PJ. Effect of sulfonamidoethylenediamine substituents in Ru arene anticancer catalysts on transfer hydrogenation of coenzyme NAD by formate. Dalton Transactions (Cambridge, England : 2003). PMID 29651471 DOI: 10.1039/c8dt00438b  0.4
2018 Coverdale JPC, Romero-Canelón I, Sanchez-Cano C, Clarkson GJ, Habtemariam A, Wills M, Sadler PJ. Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells. Nature Chemistry. 10: 347-354. PMID 29461524 DOI: 10.1038/nchem.2918  0.4
2017 Venkatesh V, Berrocal-Martin R, Wedge CJ, Romero-Canelón I, Sanchez-Cano C, Song JI, Coverdale JPC, Zhang P, Clarkson GJ, Habtemariam A, Magennis SW, Deeth RJ, Sadler PJ. Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes. Chemical Science. 8: 8271-8278. PMID 29568475 DOI: 10.1039/c7sc03216a  0.4
2017 Needham RJ, Habtemariam A, Barry NPE, Clarkson G, Sadler PJ. Halide Control of N,N-Coordination versus N,C-Cyclometalation and Stereospecific Phenyl Ring Deuteration of Osmium(II) p-Cymene Phenylazobenzothiazole Complexes. Organometallics. 36: 4367-4375. PMID 29249848 DOI: 10.1021/acs.organomet.7b00501  0.48
2017 Larnaudie SC, Brendel JC, Romero-Canelón I, Sanchez-Cano C, Catrouillet S, Sanchis J, Coverdale JPC, Song JI, Habtemariam A, Sadler PJ, Jolliffe KA, Perrier S. Cyclic peptide-polymer nanotubes as efficient and highly potent drug delivery systems for organometallic anticancer complexes. Biomacromolecules. PMID 29156128 DOI: 10.1021/acs.biomac.7b01491  0.4
2017 Hearn JM, Hughes GM, Romero-Canelón I, Munro AF, Rubio-Ruiz B, Liu Z, Carragher NO, Sadler PJ. Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action. Metallomics : Integrated Biometal Science. PMID 29131211 DOI: 10.1039/c7mt00242d  0.32
2017 Pitto-Barry A, Geraki K, Horbury MD, Stavros VG, Mosselmans JFW, Walton RI, Sadler PJ, Barry NPE. Controlled fabrication of osmium nanocrystals by electron, laser and microwave irradiation and characterisation by microfocus X-ray absorption spectroscopy. Chemical Communications (Cambridge, England). PMID 29057409 DOI: 10.1039/c7cc07133g  0.96
2017 Zhang P, Chiu CKC, Huang H, Lam YPY, Habtemariam A, Malcomson T, Paterson MJ, Clarkson GJ, O'Connor PB, Chao H, Sadler PJ. Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells. Angewandte Chemie (International Ed. in English). PMID 29047228 DOI: 10.1002/anie.201709082  0.4
2017 Wootton CA, Lam YPY, Willetts M, van Agthoven MA, Barrow MP, Sadler PJ, O Connor PB. Automatic assignment of metal-containing peptides in proteomic LC-MS and MS/MS data sets. The Analyst. PMID 28513638 DOI: 10.1039/c7an00075h  0.4
2017 Smith NA, Zhang P, Greenough SE, Horbury MD, Clarkson GJ, McFeely D, Habtemariam A, Salassa L, Stavros VG, Dowson CG, Sadler PJ. Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity. Chemical Science. 8: 395-404. PMID 28451184 DOI: 10.1039/c6sc03028a  0.44
2017 Venkatesh V, Mishra NK, Romero-Canelón I, Vernooij RR, Shi H, Coverdale JPC, Habtemariam A, Verma S, Sadler PJ. Supramolecular Photoactivatable Anticancer Hydrogels. Journal of the American Chemical Society. PMID 28414222 DOI: 10.1021/jacs.7b00186  0.4
2016 Needham RJ, Sanchez-Cano C, Zhang X, Romero-Canelón I, Habtemariam A, Cooper MS, Meszaros L, Clarkson GJ, Blower PJ, Sadler PJ. In-Cell Activation of Organo-Osmium(II) Anticancer Complexes. Angewandte Chemie (International Ed. in English). PMID 28000997 DOI: 10.1002/anie.201610290  0.4
2016 Liu HK, Kostrhunova H, Habtemariam A, Kong Y, Deeth RJ, Brabec V, Sadler PJ. "Head-to-head" double-hamburger-like structure of di-ruthenated d(GpG) adducts of mono-functional Ru-arene anticancer complexes. Dalton Transactions (Cambridge, England : 2003). PMID 27830851 DOI: 10.1039/c6dt03356c  0.4
2016 Fu Y, Romero MJ, Salassa L, Cheng X, Habtemariam A, Clarkson GJ, Prokes I, Rodger A, Costantini G, Sadler PJ. Os2 -Os4 Switch Controls DNA Knotting and Anticancer Activity. Angewandte Chemie (International Ed. in English). PMID 27240103 DOI: 10.1002/anie.201602995  0.44
2016 Venkatesh V, Wedge CJ, Romero-Canelón I, Habtemariam A, Sadler PJ. Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex. Dalton Transactions (Cambridge, England : 2003). PMID 27189101 DOI: 10.1039/c6dt01382a  0.4
2016 Fu Y, Sanchez-Cano C, Soni R, Romero-Canelon I, Hearn JM, Liu Z, Wills M, Sadler PJ. The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts. Dalton Transactions (Cambridge, England : 2003). PMID 27109147 DOI: 10.1039/c6dt01242f  0.32
2016 Carter R, Westhorpe A, Romero MJ, Habtemariam A, Gallevo CR, Bark Y, Menezes N, Sadler PJ, Sharma RA. Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes. Scientific Reports. 6: 20596. PMID 26867983 DOI: 10.1038/srep20596  1
2016 Štarha P, Habtemariam A, Romero-Canelón I, Clarkson GJ, Sadler PJ. Hydrosulfide Adducts of Organo-Iridium Anticancer Complexes. Inorganic Chemistry. PMID 26863200 DOI: 10.1021/acs.inorgchem.5b02697  0.4
2016 Hill HA, Sadler PJ. Bringing inorganic chemistry to life with inspiration from R. J. P. Williams. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 26841789 DOI: 10.1007/s00775-016-1333-3  1
2015 Brabec V, Pracharova J, Stepankova J, Sadler PJ, Kasparkova J. Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex. Journal of Inorganic Biochemistry. PMID 26778426 DOI: 10.1016/j.jinorgbio.2015.12.029  1
2015 Pitto-Barry A, Sadler PJ, Barry NP. Dynamics of formation of Ru, Os, Ir and Au metal nanocrystals on doped graphitic surfaces. Chemical Communications (Cambridge, England). PMID 26698913 DOI: 10.1039/c5cc09564f  0.96
2015 Shaili E, Fernández-Giménez M, Rodríguez-Astor S, Gandioso A, Sandín L, García-Vélez C, Massaguer A, Clarkson GJ, Woods JA, Sadler PJ, Marchán V. A Photoactivatable Platinum(IV) Anticancer Complex Conjugated to the RNA Ligand Guanidinoneomycin. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 18474-18486. PMID 26662220 DOI: 10.1002/chem.201502373  1
2015 Greenough SE, Horbury MD, Smith NA, Sadler PJ, Paterson MJ, Stavros V. Excited State Dynamics of a Two-Photon-Activatable Ruthenium Prodrug. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. PMID 26632426 DOI: 10.1002/cphc.201501075  1
2015 Soldevila-Barreda JJ, Habtemariam A, Romero-Canelón I, Sadler PJ. Half-sandwich rhodium(III) transfer hydrogenation catalysts: Reduction of NAD(+) and pyruvate, and antiproliferative activity. Journal of Inorganic Biochemistry. PMID 26601938 DOI: 10.1016/j.jinorgbio.2015.10.008  1
2015 Sriskandakumar T, Behyan S, Habtemariam A, Sadler PJ, Kennepohl P. Electrophilic Activation of Oxidized Sulfur Ligands and Implications for the Biological Activity of Ruthenium(II) Arene Anticancer Complexes. Inorganic Chemistry. PMID 26599813 DOI: 10.1021/acs.inorgchem.5b02493  1
2015 Wallace HM, Hergenrother PJ, Sadler PJ. Molecular medicine and cancer. Chemical Society Reviews. PMID 26595319 DOI: 10.1039/c5cs90123e  1
2015 Zou T, Sadler PJ. Speciation of precious metal anti-cancer complexes by NMR spectroscopy. Drug Discovery Today. Technologies. 16: 7-15. PMID 26547416 DOI: 10.1016/j.ddtec.2015.08.002  1
2015 Barry NP, Pitto-Barry A, Tran J, Spencer SE, Johansen AM, Sanchez AM, Dove AP, O'Reilly RK, Deeth RJ, Beanland R, Sadler PJ. Osmium Atoms and Os2 Molecules Move Faster on Selenium-Doped Compared to Sulfur-Doped Boronic Graphenic Surfaces. Chemistry of Materials : a Publication of the American Chemical Society. 27: 5100-5. PMID 26525180 DOI: 10.1021/acs.chemmater.5b01853  0.96
2015 Pitto-Barry A, Perdigao LM, Walker M, Lawrence J, Costantini G, Sadler PJ, Barry NP. Synthesis and controlled growth of osmium nanoparticles by electron irradiation. Dalton Transactions (Cambridge, England : 2003). PMID 26418726 DOI: 10.1039/c5dt03205a  1
2015 Romero-Canelón I, Mos M, Sadler PJ. Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation. Journal of Medicinal Chemistry. 58: 7874-80. PMID 26397305 DOI: 10.1021/acs.jmedchem.5b00655  1
2015 Hearn JM, Romero-Canelón I, Munro AF, Fu Y, Pizarro AM, Garnett MJ, McDermott U, Carragher NO, Sadler PJ. Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26162681 DOI: 10.1073/pnas.1500925112  1
2015 Millett AJ, Habtemariam A, Romero-Canelón I, Clarkson GJ, Sadler PJ. Contrasting Anticancer Activity of Half-Sandwich Iridium(III) Complexes Bearing Functionally Diverse 2-Phenylpyridine Ligands. Organometallics. 34: 2683-2694. PMID 26146437 DOI: 10.1021/acs.organomet.5b00097  0.4
2015 Gandioso A, Shaili E, Massaguer A, Artigas G, González-Cantó A, Woods JA, Sadler PJ, Marchán V. An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: synthesis and photoactivation studies. Chemical Communications (Cambridge, England). 51: 9169-72. PMID 25947177 DOI: 10.1039/c5cc03180j  1
2015 Wang M, Lai TP, Wang L, Zhang H, Yang N, Sadler PJ, Sun H. "Anion clamp" allows flexible protein to impose coordination geometry on metal ions. Chemical Communications (Cambridge, England). 51: 7867-70. PMID 25854324 DOI: 10.1039/c4cc09642h  1
2015 Coverdale JP, Sanchez-Cano C, Clarkson GJ, Soni R, Wills M, Sadler PJ. Easy To Synthesize, Robust Organo-osmium Asymmetric Transfer Hydrogenation Catalysts. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 8043-6. PMID 25853228 DOI: 10.1002/chem.201500534  1
2015 Romero-Canelón I, Sadler PJ. Systems approach to metal-based pharmacology. Proceedings of the National Academy of Sciences of the United States of America. 112: 4187-8. PMID 25825746 DOI: 10.1073/pnas.1503858112  1
2015 Soldevila-Barreda JJ, Romero-Canelón I, Habtemariam A, Sadler PJ. Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design. Nature Communications. 6: 6582. PMID 25791197 DOI: 10.1038/ncomms7582  1
2015 Soldevila-Barreda JJ, Sadler PJ. Approaches to the design of catalytic metallodrugs. Current Opinion in Chemical Biology. 25: 172-83. PMID 25765750 DOI: 10.1016/j.cbpa.2015.01.024  1
2015 Chellan P, Sadler PJ. The elements of life and medicines. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 373. PMID 25666066 DOI: 10.1098/rsta.2014.0182  1
2015 Wootton CA, Sanchez-Cano C, Liu HK, Barrow MP, Sadler PJ, O'Connor PB. Binding of an organo-osmium(II) anticancer complex to guanine and cytosine on DNA revealed by electron-based dissociations in high resolution Top-Down FT-ICR mass spectrometry. Dalton Transactions (Cambridge, England : 2003). 44: 3624-32. PMID 25650025 DOI: 10.1039/c4dt03819c  1
2015 Mukherjee A, Barnett MA, Venkatesh V, Verma S, Sadler PJ. Human serum transferrin fibrils: nanomineralisation in bacteria and destruction of red blood cells. Chembiochem : a European Journal of Chemical Biology. 16: 149-55. PMID 25476866 DOI: 10.1002/cbic.201402458  1
2015 Bessas D, Sergueev I, Merkel DG, Chumakov AI, Rüffer R, Jafari A, Kishimoto S, Wolny JA, Schünemann V, Needham RJ, Sadler PJ, Hermann RP. Nuclear resonant scattering of synchrotron radiation by Os 187 Physical Review B - Condensed Matter and Materials Physics. 91. DOI: 10.1103/PhysRevB.91.224102  1
2015 Millett AJ, Habtemariam A, Romero-Canelón I, Clarkson GJ, Sadler PJ. Contrasting Anticancer Activity of Half-Sandwich Iridium(III) Complexes Bearing Functionally Diverse 2-Phenylpyridine Ligands Organometallics. 34: 2683-2694. DOI: 10.1021/acs.organomet.5b00097  1
2015 Barry NPE, Pitto-Barry A, Tran J, Spencer SEF, Johansen AM, Sanchez AM, Dove AP, O'Reilly RK, Deeth RJ, Beanland R, Sadler PJ. Osmium Atoms and Os2 Molecules Move Faster on Selenium-Doped Compared to Sulfur-Doped Boronic Graphenic Surfaces Chemistry of Materials. 27: 5100-5105. DOI: 10.1021/acs.chemmater.5b01853  1
2015 Romero-Canelón I, Phoenix B, Pitto-Barry A, Tran J, Soldevila-Barreda JJ, Kirby N, Green S, Sadler PJ, Barry NPE. Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT) Journal of Organometallic Chemistry. DOI: 10.1016/j.jorganchem.2015.05.011  1
2015 Romero MJ, Sadler PJ. Chirality in Organometallic Anticancer Complexes Bioorganometallic Chemistry: Applications in Drug Discovery, Biocatalysis, and Imaging. 85-116. DOI: 10.1002/9783527673438.ch03  1
2014 Liu Z, Romero-Canelón I, Habtemariam A, Clarkson GJ, Sadler PJ. Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C(∧)N-Chelated and Pyridine Ligands. Organometallics. 33: 5324-5333. PMID 25328266 DOI: 10.1021/om500644f  1
2014 Barry NP, Pitto-Barry A, Romero-Canelón I, Tran J, Soldevila-Barreda JJ, Hands-Portman I, Smith CJ, Kirby N, Dove AP, O'Reilly RK, Sadler PJ. Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity. Faraday Discussions. 175: 229-40. PMID 25270092 DOI: 10.1039/c4fd00098f  1
2014 Zhu Z, Wang X, Li T, Aime S, Sadler PJ, Guo Z. Platinum(II)-gadolinium(III) complexes as potential single-molecular theranostic agents for cancer treatment. Angewandte Chemie (International Ed. in English). 53: 13225-8. PMID 25255766 DOI: 10.1002/anie.201407406  1
2014 Sousa EH, de Mesquita Vieira FG, Butler JS, Basso LA, Santiago DS, Diógenes IC, Lopes LG, Sadler PJ. [Fe(CN)5(isoniazid)](3-): an iron isoniazid complex with redox behavior implicated in tuberculosis therapy. Journal of Inorganic Biochemistry. 140: 236-44. PMID 25189361 DOI: 10.1016/j.jinorgbio.2014.08.002  1
2014 Greenough SE, Roberts GM, Smith NA, Horbury MD, McKinlay RG, ?urek JM, Paterson MJ, Sadler PJ, Stavros VG. Ultrafast photo-induced ligand solvolysis of cis-[Ru(bipyridine)2(nicotinamide)2](2+): experimental and theoretical insight into its photoactivation mechanism. Physical Chemistry Chemical Physics : Pccp. 16: 19141-55. PMID 25060066 DOI: 10.1039/c4cp02359e  1
2014 Barry NP, Pitto-Barry A, Sanchez AM, Dove AP, Procter RJ, Soldevila-Barreda JJ, Kirby N, Hands-Portman I, Smith CJ, O'Reilly RK, Beanland R, Sadler PJ. Fabrication of crystals from single metal atoms. Nature Communications. 5: 3851. PMID 24861089 DOI: 10.1038/ncomms4851  1
2014 Li H, Snelling JR, Barrow MP, Scrivens JH, Sadler PJ, O'Connor PB. Mass spectrometric strategies to improve the identification of Pt(II)-modification sites on peptides and proteins Journal of the American Society For Mass Spectrometry. 25: 1217-1227. PMID 24845349 DOI: 10.1007/s13361-014-0877-0  1
2014 Pizarro AM, McQuitty RJ, Mackay FS, Zhao Y, Woods JA, Sadler PJ. Cellular accumulation, lipophilicity and photocytotoxicity of diazido platinum(IV) anticancer complexes. Chemmedchem. 9: 1169-75. PMID 24840112 DOI: 10.1002/cmdc.201402066  1
2014 Novohradsky V, Zerzankova L, Stepankova J, Kisova A, Kostrhunova H, Liu Z, Sadler PJ, Kasparkova J, Brabec V. A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex Metallomics. 6: 1491-1501. PMID 24828756 DOI: 10.1039/c4mt00112e  1
2014 Van Rijt SH, Romero-Canelón I, Fu Y, Shnyder SD, Sadler PJ. Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells Metallomics. 6: 1014-1022. PMID 24668459 DOI: 10.1039/c4mt00034j  1
2014 Liu Z, Romero-Canelón I, Qamar B, Hearn JM, Habtemariam A, Barry NP, Pizarro AM, Clarkson GJ, Sadler PJ. The potent oxidant anticancer activity of organoiridium catalysts. Angewandte Chemie (International Ed. in English). 53: 3941-6. PMID 24616129 DOI: 10.1002/anie.201311161  0.96
2014 Liu Z, Sadler PJ. Organoiridium complexes: Anticancer agents and catalysts Accounts of Chemical Research. 47: 1174-1185. PMID 24555658 DOI: 10.1021/ar400266c  1
2014 Barry NP, Kemp TF, Sadler PJ, Hanna JV. A multinuclear 1H, 13C and 11B solid-state MAS NMR study of 16- and 18-electron organometallic ruthenium and osmium carborane complexes. Dalton Transactions (Cambridge, England : 2003). 43: 4945-9. PMID 24554004 DOI: 10.1039/c3dt53589d  1
2014 Wills RH, Habtemariam A, Lopez-Clavijo AF, Barrow MP, Sadler PJ, O'Connor PB. Insights into the binding sites of organometallic ruthenium anticancer compounds on peptides using ultra-high resolution mass spectrometry Journal of the American Society For Mass Spectrometry. 25: 662-672. PMID 24488754 DOI: 10.1007/s13361-013-0819-2  1
2014 Novohradsky V, Liu Z, Vojtiskova M, Sadler PJ, Brabec V, Kasparkova J. Mechanism of cellular accumulation of an iridium(III) pentamethylcyclopentadienyl anticancer complex containing a C,N-chelating ligand Metallomics. 6: 682-690. PMID 24448555 DOI: 10.1039/c3mt00341h  1
2014 Barry NPE, Sadler PJ. 100 years of metal coordination chemistry: From Alfred Werner to anticancer metallodrugs Pure and Applied Chemistry. 86: 1897-1910. DOI: 10.1515/pac-2014-0504  1
2014 Liu Z, Sadler PJ. Formation of glutathione sulfenate and sulfinate complexes by an organoiridium(III) anticancer complex Inorganic Chemistry Frontiers. 1: 668-672. DOI: 10.1039/c4qi00098f  1
2014 Liu Z, Romero-Canelõn I, Qamar B, Hearn JM, Habtemariam A, Barry NPE, Pizarro AM, Clarkson GJ, Sadler PJ. The potent oxidant anticancer activity of organoiridium catalysts Angewandte Chemie - International Edition. 53: 3941-3946. DOI: 10.1002/anie.201311161  1
2013 Zhao Y, Farrer NJ, Li H, Butler JS, McQuitty RJ, Habtemariam A, Wang F, Sadler PJ. De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie (International Ed. in English). 52: 13633-7. PMID 24167018 DOI: 10.1002/anie.201307505  1
2013 Fu Y, Soni R, Romero MJ, Pizarro AM, Salassa L, Clarkson GJ, Hearn JM, Habtemariam A, Wills M, Sadler PJ. Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 15199-209. PMID 24114923 DOI: 10.1002/chem.201302183  1
2013 Wu K, Liu S, Luo Q, Hu W, Li X, Wang F, Zheng R, Cui J, Sadler PJ, Xiang J, Shi Q, Xiong S. Thymines in single-stranded oligonucleotides and G-quadruplex DNA are competitive with guanines for binding to an organoruthenium anticancer complex Inorganic Chemistry. 52: 11332-11342. PMID 24024654 DOI: 10.1021/ic401606v  1
2013 Lin Y, Huang Y, Zheng W, Wang F, Habtemariam A, Luo Q, Li X, Wu K, Sadler PJ, Xiong S. Organometallic ruthenium anticancer complexes inhibit human glutathione-S-transferase π Journal of Inorganic Biochemistry. 128: 77-84. PMID 23942162 DOI: 10.1016/j.jinorgbio.2013.07.029  1
2013 Qi Y, Liu Z, Li H, Sadler PJ, O'Connor PB. Mapping the protein-binding sites for novel iridium(III) anticancer complexes using electron capture dissociation. Rapid Communications in Mass Spectrometry : Rcm. 27: 2028-32. PMID 23939971 DOI: 10.1002/rcm.6643  0.4
2013 Romero-Canelón I, Sadler PJ. Next-generation metal anticancer complexes: Multitargeting via redox modulation Inorganic Chemistry. 52: 12276-12291. PMID 23879584 DOI: 10.1021/ic400835n  1
2013 Barry NPE, Sadler PJ. Challenges for metals in medicine: How nanotechnology may help to shape the future Acs Nano. 7: 5654-5659. PMID 23837396 DOI: 10.1021/nn403220e  1
2013 Sadler PJ. Preface. Photoactivatable metal complexes: from theory to applications in biotechnology and medicine. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 371: 20130125. PMID 23776305 DOI: 10.1098/rsta.2013.0125  1
2013 Smith NA, Sadler PJ. Photoactivatable metal complexes: from theory to applications in biotechnology and medicine. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 371: 20120519. PMID 23776303 DOI: 10.1098/rsta.2012.0519  1
2013 Cubillas AM, Unterkofler S, Euser TG, Etzold BJ, Jones AC, Sadler PJ, Wasserscheid P, Russell PS. Photonic crystal fibres for chemical sensing and photochemistry. Chemical Society Reviews. 42: 8629-48. PMID 23753016 DOI: 10.1039/c3cs60128e  1
2013 Zhao Y, Woods JA, Farrer NJ, Robinson KS, Pracharova J, Kasparkova J, Novakova O, Li H, Salassa L, Pizarro AM, Clarkson GJ, Song L, Brabec V, Sadler PJ. Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 9578-91. PMID 23733242 DOI: 10.1002/chem.201300374  1
2013 Barnett JP, Blindauer CA, Kassaar O, Khazaipoul S, Martin EM, Sadler PJ, Stewart AJ. Allosteric modulation of zinc speciation by fatty acids. Biochimica Et Biophysica Acta. 1830: 5456-64. PMID 23726993 DOI: 10.1016/j.bbagen.2013.05.028  1
2013 Barry NPE, Sadler PJ. Exploration of the medical periodic table: Towards new targets Chemical Communications. 49: 5106-5131. PMID 23636600 DOI: 10.1039/c3cc41143e  1
2013 Hearn JM, Romero-Canelón I, Qamar B, Liu Z, Hands-Portman I, Sadler PJ. Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis Acs Chemical Biology. 8: 1335-1343. PMID 23618382 DOI: 10.1021/cb400070a  1
2013 Barone CR, Coletti C, McQuitty RJ, Farrer NJ, Lorusso G, Maresca L, Marrone A, Natile G, Pacifico C, Parsons S, Re N, Sadler PJ, White FJ. Photo-isomerisation of alkenyl complexes of platinum(II): structural, spectroscopic, kinetic and computational investigations. Dalton Transactions (Cambridge, England : 2003). 42: 6840-51. PMID 23493918 DOI: 10.1039/c3dt32354d  1
2013 Borfecchia E, Garino C, Salassa L, Ruiu T, Gianolio D, Zhang X, Attenkofer K, Chen LX, Gobetto R, Sadler PJ, Lamberti C. X-ray transient absorption structural characterization of the 3MLCT triplet excited state of cis-[Ru(bpy)2(py)2]2+. Dalton Transactions (Cambridge, England : 2003). 42: 6564-71. PMID 23474490 DOI: 10.1039/c3dt32865a  0.44
2013 Liu Z, Deeth RJ, Butler JS, Habtemariam A, Newton ME, Sadler PJ. Reduction of quinones by NADH catalyzed by organoiridium complexes. Angewandte Chemie (International Ed. in English). 52: 4194-7. PMID 23471835 DOI: 10.1002/anie.201300747  1
2013 Wu K, Hu W, Luo Q, Li X, Xiong S, Sadler PJ, Wang F. Competitive binding sites of a ruthenium arene anticancer complex on oligonucleotides studied by mass spectrometry: Ladder-sequencing versus top-down Journal of the American Society For Mass Spectrometry. 24: 410-420. PMID 23404464 DOI: 10.1007/s13361-012-0539-z  1
2013 Butler JS, Sadler PJ. Targeted delivery of platinum-based anticancer complexes Current Opinion in Chemical Biology. 17: 175-188. PMID 23395452 DOI: 10.1016/j.cbpa.2013.01.004  1
2013 Romero-Canelón I, Salassa L, Sadler PJ. The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes: Control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway Journal of Medicinal Chemistry. 56: 1291-1300. PMID 23368735 DOI: 10.1021/jm3017442  1
2013 Barry NPE, Deeth RJ, Clarkson GJ, Prokes I, Sadler PJ. Thermochromic organometallic complexes: Experimental and theoretical studies of 16- to 18-electron interconversions of adducts of arene Ru(ii) carboranes with aromatic amine ligands Dalton Transactions. 42: 2580-2587. PMID 23223796 DOI: 10.1039/c2dt32650g  1
2013 Wang F, Xu J, Wu K, Weidt SK, MacKay CL, Langridge-Smith PRR, Sadler PJ. Competition between glutathione and DNA oligonucleotides for ruthenium(ii) arene anticancer complexes Dalton Transactions. 42: 3188-3195. PMID 23076358 DOI: 10.1039/c2dt32091f  1
2013 Borfecchia E, Garino C, Salassa L, Ruiu T, Gianolio D, Zhang X, Attenkofer K, Chen LX, Gobetto R, Sadler PJ, Lamberti C. X-ray transient absorption structural characterization of the 3MLCT triplet excited state of cis-[Ru(bpy)2(py) 2]2+ Dalton Transactions. 42: 6564-6571. DOI: 10.1039/c3dt32865a  1
2013 Scotcher J, Clarke DJ, MacKay CL, Hupp T, Sadler PJ, Langridge-Smith PRR. Redox regulation of tumour suppressor protein p53: Identification of the sites of hydrogen peroxide oxidation and glutathionylation Chemical Science. 4: 1257-1269. DOI: 10.1039/c2sc21702c  1
2013 Pizarro AM, Barry NPE, Sadler PJ. Metal-DNA Coordination Complexes Comprehensive Inorganic Chemistry Ii (Second Edition): From Elements to Applications. 3: 751-784. DOI: 10.1016/B978-0-08-097774-4.00330-2  1
2013 Qi Y, Liu Z, Li H, Sadler PJ, O'Connor PB. Mapping the protein-binding sites for novel iridium(III) anticancer complexes using electron capture dissociation Rapid Communications in Mass Spectrometry. 27: 2028-2032. DOI: 10.1002/rcm.6643  1
2013 Betanzos-Lara S, Habtemariam A, Sadler PJ. Transfer hydrogenation reactions of photoactivatable N,N'-chelated ruthenium(II) arene complexes Journal of the Mexican Chemical Society. 57: 160-168.  1
2012 Romero-Canelón I, Pizarro AM, Habtemariam A, Sadler PJ. Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes Metallomics. 4: 1271-1279. PMID 23138378 DOI: 10.1039/c2mt20189e  1
2012 Zhao Y, Roberts GM, Greenough SE, Farrer NJ, Paterson MJ, Powell WH, Stavros VG, Sadler PJ. Two-photon-activated ligand exchange in platinum(II) complexes. Angewandte Chemie (International Ed. in English). 51: 11263-6. PMID 23047178 DOI: 10.1002/anie.201206283  1
2012 Garino C, Gallo E, Smolentsev N, Glatzel P, Gobetto R, Lamberti C, Sadler PJ, Salassa L. Resonant X-ray emission spectroscopy reveals d-d ligand-field states involved in the self-assembly of a square-planar platinum complex Physical Chemistry Chemical Physics. 14: 15278-15281. PMID 23007111 DOI: 10.1039/c2cp42451g  1
2012 Butler JS, Woods JA, Farrer NJ, Newton ME, Sadler PJ. Tryptophan switch for a photoactivated platinum anticancer complex. Journal of the American Chemical Society. 134: 16508-11. PMID 22991971 DOI: 10.1021/ja3074159  1
2012 Barragán F, Carrion-Salip D, Gómez-Pinto I, González-Cantó A, Sadler PJ, De Llorens R, Moreno V, González C, Massaguer A, Marchán V. Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes Bioconjugate Chemistry. 23: 1838-1855. PMID 22871231 DOI: 10.1021/bc300173h  1
2012 Tai HC, Zhao Y, Farrer NJ, Anastasi AE, Clarkson G, Sadler PJ, Deeth RJ. A computational approach to tuning the photochemistry of platinum(IV) anticancer agents. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 10630-42. PMID 22807241 DOI: 10.1002/chem.201200782  1
2012 Betanzos-Lara S, Novakova O, Deeth RJ, Pizarro AM, Clarkson GJ, Liskova B, Brabec V, Sadler PJ, Habtemariam A. Bipyrimidine ruthenium(II) arene complexes: Structure, reactivity and cytotoxicity Journal of Biological Inorganic Chemistry. 17: 1033-1051. PMID 22791215 DOI: 10.1007/s00775-012-0917-9  1
2012 Li H, Wells SA, Jimenez-Roldan JE, Römer RA, Zhao Y, Sadler PJ, O'Connor PB. Protein flexibility is key to cisplatin crosslinking in calmodulin Protein Science. 21: 1269-1279. PMID 22733664 DOI: 10.1002/pro.2111  1
2012 Westendorf AF, Woods JA, Korpis K, Farrer NJ, Salassa L, Robinson K, Appleyard V, Murray K, Grünert R, Thompson AM, Sadler PJ, Bednarski PJ. Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)]: a light-activated antitumor platinum complex that kills human cancer cells by an apoptosis-independent mechanism. Molecular Cancer Therapeutics. 11: 1894-904. PMID 22710878 DOI: 10.1158/1535-7163.MCT-11-0959  1
2012 Tai HC, Brodbeck R, Kasparkova J, Farrer NJ, Brabec V, Sadler PJ, Deeth RJ. Combined theoretical and computational study of interstrand DNA guanine-guanine cross-linking by trans-[Pt(pyridine)2] derived from the photoactivated prodrug trans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]. Inorganic Chemistry. 51: 6830-41. PMID 22668523 DOI: 10.1021/ic3005745  1
2012 Lu J, Stewart AJ, Sadler PJ, Pinheiro TJ, Blindauer CA. Allosteric inhibition of cobalt binding to albumin by fatty acids: implications for the detection of myocardial ischemia. Journal of Medicinal Chemistry. 55: 4425-30. PMID 22519414 DOI: 10.1021/jm3003137  1
2012 Noffke AL, Habtemariam A, Pizarro AM, Sadler PJ. Designing organometallic compounds for catalysis and therapy Chemical Communications. 48: 5219-5246. PMID 22517189 DOI: 10.1039/c2cc30678f  1
2012 Ross A, Choi JH, Hunter TM, Pannecouque C, Moggach SA, Parsons S, De Clercq E, Sadler PJ. Zinc(II) complexes of constrained antiviral macrocycles. Dalton Transactions (Cambridge, England : 2003). 41: 6408-18. PMID 22466936 DOI: 10.1039/c2dt30140g  1
2012 Pracharova J, Zerzankova L, Stepankova J, Novakova O, Farrer NJ, Sadler PJ, Brabec V, Kasparkova J. Interactions of DNA with a new platinum(IV) azide dipyridine complex activated by UVA and visible light: Relationship to toxicity in tumor cells Chemical Research in Toxicology. 25: 1099-1111. PMID 22420335 DOI: 10.1021/tx300057y  1
2012 Betanzos-Lara S, Liu Z, Habtemariam A, Pizarro AM, Qamar B, Sadler PJ. Organometallic ruthenium and iridium transfer-hydrogenation catalysts using coenzyme NADH as a cofactor. Angewandte Chemie (International Ed. in English). 51: 3897-900. PMID 22415924 DOI: 10.1002/anie.201108175  1
2012 Mukherjee A, Bilton PR, Mackay L, Janoschka A, Zhu H, Rea D, Langridge-Smith PR, Campopiano DJ, Teschner T, Trautwein AX, Schünemann V, Sadler PJ. Ferric ion (hydr)oxo clusters in the "Venus flytrap" cleft of FbpA: Mössbauer, calorimetric and mass spectrometric studies. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 573-88. PMID 22349975 DOI: 10.1007/s00775-012-0878-z  1
2012 Barry NPE, Sadler PJ. Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium: Biological relevance and synthetic strategies Chemical Society Reviews. 41: 3264-3279. PMID 22307021 DOI: 10.1039/c2cs15300a  1
2012 Wu K, Luo Q, Hu W, Li X, Wang F, Xiong S, Sadler PJ. Mechanism of interstrand migration of organoruthenium anticancer complexes within a DNA duplex. Metallomics : Integrated Biometal Science. 4: 139-48. PMID 22262368 DOI: 10.1039/c2mt00162d  1
2012 Lu J, Stewart AJ, Sleep D, Sadler PJ, Pinheiro TJ, Blindauer CA. A molecular mechanism for modulating plasma Zn speciation by fatty acids. Journal of the American Chemical Society. 134: 1454-7. PMID 22239162 DOI: 10.1021/ja210496n  1
2012 Booyjzsen C, Scarff CA, Moreton B, Portman I, Scrivens JH, Costantini G, Sadler PJ. Fibrillation of transferrin. Biochimica Et Biophysica Acta. 1820: 427-36. PMID 22119572 DOI: 10.1016/j.bbagen.2011.11.004  1
2012 Unterkofler S, McQuitty RJ, Euser TG, Farrer NJ, Sadler PJ, Russell PSJ. Microfluidic integration of photonic crystal fibers for online photochemical reaction analysis Optics Letters. 37: 1952-1954. DOI: 10.1364/OL.37.001952  1
2012 Fu Y, Romero MJ, Habtemariam A, Snowden ME, Song L, Clarkson GJ, Qamar B, Pizarro AM, Unwin PR, Sadler PJ. The contrasting chemical reactivity of potent isoelectronic iminopyridine and azopyridine osmium(ii) arene anticancer complexes Chemical Science. 3: 2485-2494. DOI: 10.1039/c2sc20220d  1
2012 Soldevila-Barreda JJ, Bruijnincx PCA, Habtemariam A, Clarkson GJ, Deeth RJ, Sadler PJ. Improved catalytic activity of ruthenium-arene complexes in the reduction of NAD + Organometallics. 31: 5958-5967. DOI: 10.1021/om3006307  1
2012 Betanzos-Lara S, Salassa L, Habtemariam A, Novakova O, Pizarro AM, Clarkson GJ, Liskova B, Brabec V, Sadler PJ. Photoactivatable organometallic pyridyl ruthenium(II) arene complexes Organometallics. 31: 3466-3479. DOI: 10.1021/om201177y  1
2012 Ragazzon G, Bratsos I, Alessio E, Salassa L, Habtemariam A, McQuitty RJ, Clarkson GJ, Sadler PJ. Design of photoactivatable metallodrugs: Selective and rapid light-induced ligand dissociation from half-sandwich [Ru([9]aneS 3)(N-N′)(py)] 2+ complexes Inorganica Chimica Acta. 393: 230-238. DOI: 10.1016/j.ica.2012.06.031  1
2012 Liu HK, Sadler PJ. Interactions of Metallodrugs with DNA Nmr of Biomolecules: Towards Mechanistic Systems Biology. 282-296. DOI: 10.1002/9783527644506.ch16  1
2012 Unterkofler S, McQuitty RJ, Euser TG, Farrer NJ, Sadler PJ, Russell PSJ. Optofluidic hollow-core photonic crystal fiber coupled to mass spectrometry for rapid photochemical reaction analysis 2012 Conference On Lasers and Electro-Optics, Cleo 2012 1
2011 Betanzos-Lara S, Habtemariam A, Clarkson GJ, Sadler PJ. Organometallic cis-Dichlorido Ruthenium(II) Ammine Complexes. European Journal of Inorganic Chemistry. 2011: 3257-3264. PMID 23956682 DOI: 10.1002/ejic.201100250  1
2011 Li H, Lin TY, Van Orden SL, Zhao Y, Barrow MP, Pizarro AM, Qi Y, Sadler PJ, O'Connor PB. Use of top-down and bottom-up Fourier transform ion cyclotron resonance mass spectrometry for mapping calmodulin sites modified by platinum anticancer drugs. Analytical Chemistry. 83: 9507-15. PMID 22032417 DOI: 10.1021/ac202267g  1
2011 Han Y, Luo Q, Hao X, Li X, Wang F, Hu W, Wu K, Lü S, Sadler PJ. Reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide--a model for the active-site cysteine of protein tyrosine phosphatase 1B. Dalton Transactions (Cambridge, England : 2003). 40: 11519-29. PMID 21960108 DOI: 10.1039/c1dt11189b  1
2011 Farrer NJ, Gierth P, Sadler PJ. Probing platinum azido complexes by 14N and 15N NMR spectroscopy. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 12059-66. PMID 21922574 DOI: 10.1002/chem.201101409  1
2011 Ronconi L, Pizarro AM, McQuitty RJ, Sadler PJ. Insights into the acid-base properties of Pt(IV)-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 12051-8. PMID 21922567 DOI: 10.1002/chem.201002792  1
2011 Fu Y, Habtemariam A, Basri AM, Braddick D, Clarkson GJ, Sadler PJ. Structure-activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity. Dalton Transactions (Cambridge, England : 2003). 40: 10553-62. PMID 21860862 DOI: 10.1039/c1dt10937e  1
2011 Barragán F, López-Senín P, Salassa L, Betanzos-Lara S, Habtemariam A, Moreno V, Sadler PJ, Marchán V. Photocontrolled DNA binding of a receptor-targeted organometallic ruthenium(II) complex. Journal of the American Chemical Society. 133: 14098-108. PMID 21797210 DOI: 10.1021/ja205235m  1
2011 Liu Z, Salassa L, Habtemariam A, Pizarro AM, Clarkson GJ, Sadler PJ. Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorganic Chemistry. 50: 5777-83. PMID 21618978 DOI: 10.1021/ic200607j  1
2011 Li H, Zhao Y, Phillips HI, Qi Y, Lin TY, Sadler PJ, O'Connor PB. Mass spectrometry evidence for cisplatin as a protein cross-linking reagent. Analytical Chemistry. 83: 5369-76. PMID 21591778 DOI: 10.1021/ac200861k  1
2011 Hu W, Luo Q, Wu K, Li X, Wang F, Chen Y, Ma X, Wang J, Liu J, Xiong S, Sadler PJ. The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin. Chemical Communications (Cambridge, England). 47: 6006-8. PMID 21526258 DOI: 10.1039/c1cc11627d  1
2011 Kisova A, Zerzankova L, Habtemariam A, Sadler PJ, Brabec V, Kasparkova J. Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand. Molecular Pharmaceutics. 8: 949-57. PMID 21480648 DOI: 10.1021/mp200105d  1
2011 Scotcher J, Clarke DJ, Weidt SK, Mackay CL, Hupp TR, Sadler PJ, Langridge-Smith PR. Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry. Journal of the American Society For Mass Spectrometry. 22: 888-97. PMID 21472523 DOI: 10.1007/s13361-011-0088-x  1
2011 Westendorf AF, Zerzankova L, Salassa L, Sadler PJ, Brabec V, Bednarski PJ. Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)]. Journal of Inorganic Biochemistry. 105: 652-62. PMID 21450268 DOI: 10.1016/j.jinorgbio.2011.01.003  1
2011 Liu HK, Sadler PJ. Metal complexes as DNA intercalators. Accounts of Chemical Research. 44: 349-59. PMID 21446672 DOI: 10.1021/ar100140e  1
2011 Liu Z, Habtemariam A, Pizarro AM, Fletcher SA, Kisova A, Vrana O, Salassa L, Bruijnincx PC, Clarkson GJ, Brabec V, Sadler PJ. Organometallic half-sandwich iridium anticancer complexes. Journal of Medicinal Chemistry. 54: 3011-26. PMID 21443199 DOI: 10.1021/jm2000932  1
2011 Rijt SH, Kostrhunova H, Brabec V, Sadler PJ. Functionalization of osmium arene anticancer complexes with (poly)arginine: effect on cellular uptake, internalization, and cytotoxicity. Bioconjugate Chemistry. 22: 218-26. PMID 21271713 DOI: 10.1021/bc100369p  1
2011 Ronconi L, Sadler PJ. Photoreaction pathways for the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2]. Dalton Transactions (Cambridge, England : 2003). 40: 262-8. PMID 21076743 DOI: 10.1039/c0dt00546k  1
2011 Shnyder SD, Fu Y, Habtemariam A, Van Rijt SH, Cooper PA, Loadman PM, Sadler PJ. Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex Medchemcomm. 2: 666-668. DOI: 10.1039/c1md00075f  1
2011 Liu Z, Habtemariam A, Pizarro AM, Clarkson GJ, Sadler PJ. Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-Chelating ligands Organometallics. 30: 4702-4710. DOI: 10.1021/om2005468  1
2011 Farrer NJ, Sadler PJ. Medicinal Inorganic Chemistry: State of the Art, New Trends, and a Vision of the Future Bioinorganic Medicinal Chemistry. 1-47. DOI: 10.1002/9783527633104.ch1  1
2010 Salassa L, Borfecchia E, Ruiu T, Garino C, Gianolio D, Gobetto R, Sadler PJ, Cammarata M, Wulff M, Lamberti C. Photo-induced pyridine substitution in cis-[Ru(bpy)(2)(py)(2)]Cl(2): a snapshot by time-resolved X-ray solution scattering. Inorganic Chemistry. 49: 11240-8. PMID 21038911 DOI: 10.1021/ic102021k  1
2010 Fu Y, Habtemariam A, Pizarro AM, van Rijt SH, Healey DJ, Cooper PA, Shnyder SD, Clarkson GJ, Sadler PJ. Organometallic osmium arene complexes with potent cancer cell cytotoxicity. Journal of Medicinal Chemistry. 53: 8192-6. PMID 20977192 DOI: 10.1021/jm100560f  1
2010 Farrer NJ, Woods JA, Salassa L, Zhao Y, Robinson KS, Clarkson G, Mackay FS, Sadler PJ. A potent trans-diimine platinum anticancer complex photoactivated by visible light. Angewandte Chemie (International Ed. in English). 49: 8905-8. PMID 20677309 DOI: 10.1002/anie.201003399  1
2010 Cubo L, Pizarro AM, Quiroga AG, Salassa L, Navarro-Ranninger C, Sadler PJ. Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides. Journal of Inorganic Biochemistry. 104: 909-18. PMID 20546905 DOI: 10.1016/j.jinorgbio.2010.04.009  1
2010 Shi Y, Harvey I, Campopiano D, Sadler PJ. Niobium uptake and release by bacterial ferric ion binding protein. Bioinorganic Chemistry and Applications. 307578. PMID 20445753 DOI: 10.1155/2010/307578  1
2010 Chen JS, Euser TG, Farrer NJ, Sadler PJ, Scharrer M, Russell PS. Photochemistry in photonic crystal fiber nanoreactors. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 5607-12. PMID 20391563 DOI: 10.1002/chem.201000496  1
2010 Novakova O, Malina J, Suchankova T, Kasparkova J, Bugarcic T, Sadler PJ, Brabec V. Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru(II) complexes containing terphenyl arenes. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 5744-54. PMID 20376825 DOI: 10.1002/chem.200903078  1
2010 Pizarro AM, Melchart M, Habtemariam A, Salassa L, Fabbiani FP, Parsons S, Sadler PJ. Controlling the reactivity of ruthenium(II) arene complexes by tether ring-opening. Inorganic Chemistry. 49: 3310-9. PMID 20205442 DOI: 10.1021/ic902243q  1
2010 Ross A, Soares DC, Covelli D, Pannecouque C, Budd L, Collins A, Robertson N, Parsons S, De Clercq E, Kennepohl P, Sadler PJ. Oxovanadium(IV) cyclam and bicyclam complexes: potential CXCR4 receptor antagonists. Inorganic Chemistry. 49: 1122-32. PMID 20039648 DOI: 10.1021/ic9020614  1
2010 van Rijt SH, Mukherjee A, Pizarro AM, Sadler PJ. Cytotoxicity, hydrophobicity, uptake, and distribution of osmium(II) anticancer complexes in ovarian cancer cells. Journal of Medicinal Chemistry. 53: 840-9. PMID 20000847 DOI: 10.1021/jm901556u  1
2010 Farrer NJ, Woods JA, Munk VP, Mackay FS, Sadler PJ. Photocytotoxic trans-diam(m)ine platinum(IV) diazido complexes more potent than their cis isomers. Chemical Research in Toxicology. 23: 413-21. PMID 19994893 DOI: 10.1021/tx900372p  1
2010 Bergamo A, Masi A, Peacock AF, Habtemariam A, Sadler PJ, Sava G. In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model. Journal of Inorganic Biochemistry. 104: 79-86. PMID 19906432 DOI: 10.1016/j.jinorgbio.2009.10.005  1
2010 Euser TG, Garbos MK, Chen JSY, Farrer NJ, Scharrer M, Sadler PJ, Russell PSJ. Particle guidance and photochemistry in hollow-core photonic crystal fibre 2010 Photonics Global Conference, Pgc 2010. DOI: 10.1109/PGC.2010.5706080  1
2010 Liu HK, Parkinson JA, Bella J, Wang F, Sadler PJ. Penetrative DNA intercalation and G-base selectivity of an organometallic tetrahydroanthracene RuII anticancer complex Chemical Science. 1: 258-270. DOI: 10.1039/c0sc00175a  1
2010 Farrer NJ, Monk N, Heron J, Lough JA, Sadler PJ. (RSC)2: Chemistry, performance, and pedagogy - an interactive approach to periodic trends Chemistry Education Research and Practice. 11: 308-313. DOI: 10.1039/c0rp90011g  1
2010 Salassa L, Ruiu T, Garino C, Pizarro AM, Bardelli F, Gianolio D, Westendorf A, Bednarski PJ, Lamberti C, Gobetto R, Sadler PJ. EXAFS, DFT, light-induced nucleobase binding, and cytotoxicity of the photoactive complex cis-[Ru(bpy)2(CO)Cl]+ Organometallics. 29: 6703-6710. DOI: 10.1021/om100734y  1
2010 Pizarro AM, Habtemariam A, Sadler PJ. Activation mechanisms for organometallic anticancer complexes Topics in Organometallic Chemistry. 32: 21-56. DOI: 10.1007/978-3-642-13185-1_2  1
2010 Ruiu T, Garino C, Salassa L, Pizarro AM, Nervi C, Gobetto R, Sadler PJ. Spectroscopic and computational study of ligand photodissociation from [Ru(dipyrido[3,2-a2′:3′-c]phenazine)(4-aminopyridine) 4]2+ European Journal of Inorganic Chemistry. 1186-1195. DOI: 10.1002/ejic.200900990  1
2010 Habtemariam A, Betanzos-Lara S, Sadler PJ, Trufan E, Adams RD. Ruthenium Complexes: DI-μ-Chloro(Ethylbenzoate)Diruthenium(II), [(η6-etb)RuCl2]2 Inorganic Syntheses. 35: 160-163. DOI: 10.1002/9780470651568.ch8  1
2009 Farrer NJ, Salassa L, Sadler PJ. Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine. Dalton Transactions (Cambridge, England : 2003). 10690-701. PMID 20023896 DOI: 10.1039/b917753a  1
2009 Sadler PJ. Dalton Transactions themed issue on metal anticancer compounds. Dalton Transactions (Cambridge, England : 2003). 10647. PMID 20023890 DOI: 10.1039/b923498p  1
2009 Salassa L, Phillips HI, Sadler PJ. Decomposition pathways for the photoactivated anticancer complex cis,trans,cis-[Pt(N3)2(OH)2(NH3)2]: insights from DFT calculations. Physical Chemistry Chemical Physics : Pccp. 11: 10311-6. PMID 19890514 DOI: 10.1039/b912496a  1
2009 Betanzos-Lara S, Salassa L, Habtemariam A, Sadler PJ. Photocontrolled nucleobase binding to an organometallic Ru(II) arene complex. Chemical Communications (Cambridge, England). 6622-4. PMID 19865670 DOI: 10.1039/b914153g  1
2009 Van Rijt SH, Hebden AJ, Amaresekera T, Deeth RJ, Clarkson GJ, Parsons S, McGowan PC, Sadler PJ. Amide linkage isomerism as an activity switch for organometallic osmium and ruthenium anticancer complexes Journal of Medicinal Chemistry. 52: 7753-7764. PMID 19791745 DOI: 10.1021/jm900731j  1
2009 van Rijt SH, Sadler PJ. Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discovery Today. 14: 1089-97. PMID 19782150 DOI: 10.1016/j.drudis.2009.09.003  1
2009 Bugarcic T, Habtemariam A, Deeth RJ, Fabbiani FPA, Parsons S, Sadler PJ. Ruthenium(ll) arene anticancer complexes with redox-active diamine ligands Inorganic Chemistry. 48: 9444-9453. PMID 19780621 DOI: 10.1021/ic9013366  1
2009 Newstead S, Fowler PW, Bilton P, Carpenter EP, Sadler PJ, Campopiano DJ, Sansom MS, Iwata S. Insights into how nucleotide-binding domains power ABC transport. Structure (London, England : 1993). 17: 1213-22. PMID 19748342 DOI: 10.1016/j.str.2009.07.009  1
2009 Sriskandakumar T, Petzold H, Bruijnincx PC, Habtemariam A, Sadler PJ, Kennepohl P. Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT. Journal of the American Chemical Society. 131: 13355-61. PMID 19719101 DOI: 10.1021/ja903405z  1
2009 Stewart AJ, Blindauer CA, Sadler PJ. Plasma fatty acid levels may regulate the Zn(2+)-dependent activities of histidine-rich glycoprotein. Biochimie. 91: 1518-22. PMID 19679159 DOI: 10.1016/j.biochi.2009.08.002  1
2009 Hu W, Luo Q, Ma X, Wu K, Liu J, Chen Y, Xiong S, Wang J, Sadler PJ, Wang F. Arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 6586-94. PMID 19533706 DOI: 10.1002/chem.200900699  1
2009 Blindauer CA, Harvey I, Bunyan KE, Stewart AJ, Sleep D, Harrison DJ, Berezenko S, Sadler PJ. Structure, properties, and engineering of the major zinc binding site on human albumin. The Journal of Biological Chemistry. 284: 23116-24. PMID 19520864 DOI: 10.1074/jbc.M109.003459  1
2009 Wang F, Habtemariam A, van der Geer EP, Deeth RJ, Gould R, Parsons S, Sadler PJ. Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 14: 1065-76. PMID 19499253 DOI: 10.1007/s00775-009-0549-x  1
2009 Pizarro AM, Sadler PJ. Unusual DNA binding modes for metal anticancer complexes Biochimie. 91: 1198-1211. PMID 19344743 DOI: 10.1016/j.biochi.2009.03.017  1
2009 Williams JP, Bugarcic T, Habtemariam A, Giles K, Campuzano I, Rodger PM, Sadler PJ. Isomer separation and gas-phase configurations of organoruthenium anticancer complexes: ion mobility mass spectrometry and modeling. Journal of the American Society For Mass Spectrometry. 20: 1119-22. PMID 19297193 DOI: 10.1016/j.jasms.2009.02.016  0.4
2009 Mackay FS, Farrer NJ, Salassa L, Tai HC, Deeth RJ, Moggach SA, Wood PA, Parsons S, Sadler PJ. Synthesis, characterisation and photochemistry of Pt(IV) pyridyl azido acetato complexes. Dalton Transactions (Cambridge, England : 2003). 2315-25. PMID 19290364 DOI: 10.1039/b820550g  1
2009 Diakos CI, Messerle BA, Murdoch Pdel S, Parkinson JA, Sadler PJ, Fenton RR, Hambley TW. Identification by NMR spectroscopy of the two stereoisomers of the platinum complex [PtCl2(S-ahaz)] (S-ahaz = 3(S)-aminohexahydroazepine) bound to a DNA 14-mer oligonucleotide. NMR evidence of structural alteration of a platinated A x T-rich 14-mer DNA duplex. Inorganic Chemistry. 48: 3047-56. PMID 19265406 DOI: 10.1021/ic802207m  1
2009 van Rijt SH, Peacock AF, Johnstone RD, Parsons S, Sadler PJ. Organometallic osmium(II) arene anticancer complexes containing picolinate derivatives. Inorganic Chemistry. 48: 1753-62. PMID 19146436 DOI: 10.1021/ic8020222  0.36
2009 Chen JSY, Euser TG, Fairer NJ, Sadler PJ, Russell PSJ. Photochemistry in photonic crystal fibers Cleo/Europe - Eqec 2009 - European Conference On Lasers and Electro-Optics and the European Quantum Electronics Conference. DOI: 10.1109/CLEOE-EQEC.2009.5196326  1
2009 Salassa L, Gianolio D, Garino C, Salassa G, Borfecchia E, Ruiu T, Nervi C, Gobetto R, Bizzarri R, Sadler PJ, Lamberti C. Structure of [Ru(bpy)n(AP)(6-2n)]2+ homogeneous complexes: DFT calculation vs. EXAFS Journal of Physics: Conference Series. 190. DOI: 10.1088/1742-6596/190/1/012141  1
2009 Bruijnincx PCA, Sadler PJ. Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design Advances in Inorganic Chemistry. 61: 1-62. DOI: 10.1016/S0898-8838(09)00201-3  1
2009 Gray JC, Pagelot A, Collins A, Fabbiani FPA, Parsons S, Sadler PJ. Organometallic osmium(II) and ruthenium(II) biphenyl sandwich complexes: X-ray crystal structures and 187Os NMR spectroscopic studies in solution European Journal of Inorganic Chemistry. 2009: 2673-2677. DOI: 10.1002/ejic.200900244  1
2009 Sadler PJ. Precious anticancer drugs Chemistry and Industry (London). 18-20.  1
2008 Bugarcic T, Habtemariam A, Stepankova J, Heringova P, Kasparkova J, Deeth RJ, Johnstone RDL, Prescimone A, Parkin A, Parsons S, Brabec V, Sadler PJ. The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes Inorganic Chemistry. 47: 11470-11486. PMID 19007206 DOI: 10.1021/ic801361m  1
2008 Bugarcic T, Nováková O, Halámiková A, Zerzánková L, Vrána O, Kaspárková J, Habtemariam A, Parsons S, Sadler PJ, Brabec V. Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes. Journal of Medicinal Chemistry. 51: 5310-9. PMID 18702458 DOI: 10.1021/jm8003043  0.4
2008 Gray JC, Habtemariam A, Winnig M, Meyerhof W, Sadler PJ. Sweetening ruthenium and osmium: organometallic arene complexes containing aspartame. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 13: 1111-20. PMID 18553111 DOI: 10.1007/s00775-008-0396-1  1
2008 Euser TG, Chen JSY, Farrer NJ, Scharrer M, Sadler PJ, Russell PSJ. Quantitative broadband chemical sensing in air-suspended solid-core fibers 2008 Conference On Quantum Electronics and Laser Science Conference On Lasers and Electro-Optics, Cleo/Qels. DOI: 10.1109/CLEO.2008.4551326  1
2007 Mackay FS, Woods JA, Heringová P, Kaspárková J, Pizarro AM, Moggach SA, Parsons S, Brabec V, Sadler PJ. A potent cytotoxic photoactivated platinum complex. Proceedings of the National Academy of Sciences of the United States of America. 104: 20743-8. PMID 18093923 DOI: 10.1073/pnas.0707742105  0.36
2007 Hoeschele JD, Habtemariam A, Muir J, Sadler PJ. 106Ru radiolabelling of the antitumour complex [(eta6-fluorene)Ru(en)Cl]PF6. Dalton Transactions (Cambridge, England : 2003). 4974-9. PMID 17992282 DOI: 10.1039/b706246j  1
2007 Melchart M, Habtemariam A, Parsons S, Sadler PJ. Chlorido-, aqua-, 9-ethylguanine- and 9-ethyladenine-adducts of cytotoxic ruthenium arene complexes containing O,O-chelating ligands. Journal of Inorganic Biochemistry. 101: 1903-12. PMID 17582501 DOI: 10.1016/j.jinorgbio.2007.04.018  0.4
2007 Magennis SW, Habtemariam A, Novakova O, Henry JB, Meier S, Parsons S, Oswald IDH, Brabec V, Sadler PJ. Dual triggering of DNA binding and fluorescence via photoactivation of a dinuclear ruthenium(II) arene complex Inorganic Chemistry. 46: 5059-5068. PMID 17497848 DOI: 10.1021/ic062111q  1
2007 Morgan HP, Estibeiro P, Wear MA, Max KE, Heinemann U, Cubeddu L, Gallagher MP, Sadler PJ, Walkinshaw MD. Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach. Nucleic Acids Research. 35: e75. PMID 17488853 DOI: 10.1093/nar/gkm040  1
2007 Peacock AF, Habtemariam A, Moggach SA, Prescimone A, Parsons S, Sadler PJ. Chloro half-sandwich osmium(II) complexes: influence of chelated N,N-ligands on hydrolysis, guanine binding, and cytotoxicity. Inorganic Chemistry. 46: 4049-59. PMID 17441712 DOI: 10.1021/ic062350d  1
2007 Peacock AF, Parsons S, Sadler PJ. Tuning the hydrolytic aqueous chemistry of osmium arene complexes with N,O-chelating ligands to achieve cancer cell cytotoxicity. Journal of the American Chemical Society. 129: 3348-57. PMID 17319668 DOI: 10.1021/ja068335p  0.36
2007 Hunter TM, McNae IW, Simpson DP, Smith AM, Moggach S, White F, Walkinshaw MD, Parsons S, Sadler PJ. Configurations of nickel-cyclam antiviral complexes and protein recognition Chemistry - a European Journal. 13: 40-50. PMID 17120266 DOI: 10.1002/chem.200601334  1
2007 Zobi F, Mood BB, Wood PA, Fabbiani FPA, Parsons S, Sadler PJ. Tagging (arene)ruthenium(II) anticancer complexes with fluorescent labels European Journal of Inorganic Chemistry. 2783-2796. DOI: 10.1002/ejic.200700144  1
2007 Peacock AFA, Melchart M, Deeth RJ, Habtemariam A, Parsons S, Sadler PJ. Osmium(II) and ruthenium(II) arene maltolato complexes: Rapid hydrolysis and nucleobase binding Chemistry - a European Journal. 13: 2601-2613. DOI: 10.1002/chem.200601152  1
2006 Habtemariam A, Melchart M, Fernandez R, Parsons S, Oswald ID, Parkin A, Fabbiani FP, Davidson JE, Dawson A, Aird RE, Jodrell DI, Sadler PJ. Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands. Journal of Medicinal Chemistry. 49: 6858-68. PMID 17154516 DOI: 10.1021/jm060596m  0.4
2006 Liu HK, Berners-Price SJ, Wang F, Parkinson JA, Xu J, Bella J, Sadler PJ. Diversity in guanine-selective DNA binding modes for an organometallic ruthenium arene complex. Angewandte Chemie (International Ed. in English). 45: 8153-6. PMID 17120267 DOI: 10.1002/anie.200602873  1
2006 Valks GC, McRobbie G, Lewis EA, Hubin TJ, Hunter TM, Sadler PJ, Pannecouque C, De Clercq E, Archibald SJ. Configurationally restricted bismacrocyclic CXCR4 receptor antagonists. Journal of Medicinal Chemistry. 49: 6162-5. PMID 17034122 DOI: 10.1021/jm0607810  1
2006 Liu HK, Wang F, Parkinson JA, Bella J, Sadler PJ. Ruthenation of duplex and single-stranded d(CGGCCG) by organometallic anticancer complexes. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 6151-65. PMID 16807967 DOI: 10.1002/chem.200600110  1
2006 Yan YK, Melchart M, Habtemariam A, Peacock AF, Sadler PJ. Catalysis of regioselective reduction of NAD+ by ruthenium(II) arene complexes under biologically relevant conditions. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 11: 483-8. PMID 16604356 DOI: 10.1007/s00775-006-0098-5  0.4
2006 Paradies J, Crudass J, Mackay F, Yellowlees LJ, Montgomery J, Parsons S, Oswald I, Robertson N, Sadler PJ. Photogeneration of titanium(III) from titanium(IV) citrate in aqueous solution. Journal of Inorganic Biochemistry. 100: 1260-4. PMID 16603248 DOI: 10.1016/j.jinorgbio.2006.02.011  0.36
2006 Mackay FS, Woods JA, Moseley H, Ferguson J, Dawson A, Parsons S, Sadler PJ. A photoactivated trans-diammine platinum complex as cytotoxic as cisplatin. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 3155-61. PMID 16470886 DOI: 10.1002/chem.200501601  0.36
2006 Peacock AF, Habtemariam A, Fernández R, Walland V, Fabbiani FP, Parsons S, Aird RE, Jodrell DI, Sadler PJ. Tuning the reactivity of osmium(II) and ruthenium(II) arene complexes under physiological conditions. Journal of the American Chemical Society. 128: 1739-48. PMID 16448150 DOI: 10.1021/ja055886r  0.4
2005 Wang F, Habtemariam A, Van Der Geer EPL, Fernández R, Melchart M, Deeth RJ, Aird R, Guichard S, Fabbiani FPA, Lozano-Casal P, Oswald IDH, Jodrell DI, Parsons S, Sadler PJ. Controlling ligand substitution reactions of organometallic complexes: Tuning cancer cell cytotoxicity Proceedings of the National Academy of Sciences of the United States of America. 102: 18269-18274. PMID 16352726 DOI: 10.1073/pnas.0505798102  1
2005 Wang F, Xu J, Habtemariam A, Bella J, Sadler PJ. Competition between glutathione and guanine for a ruthenium(II) arene anticancer complex: detection of a sulfenato intermediate. Journal of the American Chemical Society. 127: 17734-43. PMID 16351102 DOI: 10.1021/ja053387k  0.4
2005 Wang F, Bella J, Parkinson JA, Sadler PJ. Competitive reactions of a ruthenium arene anticancer complex with histidine, cytochrome c and an oligonucleotide. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 10: 147-55. PMID 15735959 DOI: 10.1007/s00775-004-0621-5  1
2005 Magennis SW, Mackay FS, Jones AC, Tait KM, Sadler PJ. Two-photon-induced photoisomerization of an azo dye Chemistry of Materials. 17: 2059-2062. DOI: 10.1021/cm048020d  1
2004 Zhong W, Parkinson JA, Parsons S, Oswald ID, Coxall RA, Sadler PJ. Structure and dynamics of dinuclear zirconium(IV) complexes. Inorganic Chemistry. 43: 3561-72. PMID 15180408 DOI: 10.1021/ic049932k  1
2004 Hunter TM, Paisey SJ, Park HS, Cleghorn L, Parkin A, Parsons S, Sadler PJ. Configurations of metallocyclams and relevance to anti-HIV activity. Journal of Inorganic Biochemistry. 98: 713-9. PMID 15134916 DOI: 10.1016/j.jinorgbio.2003.10.018  0.36
2004 Borrelly GP, Blindauer CA, Schmid R, Butler CS, Cooper CE, Harvey I, Sadler PJ, Robinson NJ. A novel copper site in a cyanobacterial metallochaperone. The Biochemical Journal. 378: 293-7. PMID 14711369 DOI: 10.1042/BJ20031669  1
2003 Wang F, Chen H, Parsons S, Oswald ID, Davidson JE, Sadler PJ. Kinetics of aquation and anation of ruthenium(II) arene anticancer complexes, acidity and X-ray structures of aqua adducts. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 5810-20. PMID 14673852 DOI: 10.1002/chem.200304724  0.36
2003 Chen H, Parkinson JA, Nováková O, Bella J, Wang F, Dawson A, Gould R, Parsons S, Brabec V, Sadler PJ. Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers. Proceedings of the National Academy of Sciences of the United States of America. 100: 14623-8. PMID 14657383 DOI: 10.1073/pnas.2434016100  1
2003 Liang X, Weishäupl M, Parkinson JA, Parsons S, McGregor PA, Sadler PJ. Selective recognition of configurational substates of zinc cyclam by carboxylates: implications for the design and mechanism of action of anti-HIV agents. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 4709-17. PMID 14566877 DOI: 10.1002/chem.200304808  1
2003 Vinje J, Parkinson JA, Sadler PJ, Brown T, Sletten E. Sequence-selective metalation of double-helical oligodeoxyribonucleotides with PtII, MnII, and ZnII ions. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 1620-30. PMID 12658661 DOI: 10.1002/chem.200390186  1
2003 Blindauer CA, Polfer NC, Keiper SE, Harrison MD, Robinson NJ, Langridge-Smith PR, Sadler PJ. Inert site in a protein zinc cluster: isotope exchange by high resolution mass spectrometry. Journal of the American Chemical Society. 125: 3226-7. PMID 12630873 DOI: 10.1021/ja0284409  1
2003 Müller P, Schröder B, Parkinson JA, Kratochwil NA, Coxall RA, Parkin A, Parsons S, Sadler PJ. Nucleotide cross-linking induced by photoreactions of platinum(IV)-azide complexes. Angewandte Chemie (International Ed. in English). 42: 335-9. PMID 12548693 DOI: 10.1002/anie.200390110  1
2003 Chen H, Parkinson JA, Morris RE, Sadler PJ. Highly selective binding of organometallic ruthenium ethylenediamine complexes to nucleic acids: novel recognition mechanisms. Journal of the American Chemical Society. 125: 173-86. PMID 12515520 DOI: 10.1021/ja027719m  1
2003 Guo M, Harvey I, Yang W, Coghill L, Campopiano DJ, Parkinson JA, MacGillivray RT, Harris WR, Sadler PJ. Synergistic anion and metal binding to the ferric ion-binding protein from Neisseria gonorrhoeae. The Journal of Biological Chemistry. 278: 2490-502. PMID 12372824 DOI: 10.1074/jbc.M208776200  1
2002 Blindauer CA, Harrison MD, Robinson AK, Parkinson JA, Bowness PW, Sadler PJ, Robinson NJ. Multiple bacteria encode metallothioneins and SmtA-like zinc fingers. Molecular Microbiology. 45: 1421-32. PMID 12207707 DOI: 10.1046/j.1365-2958.2002.03109.x  1
2002 Liang X, Parkinson JA, Parsons S, Weishäupl M, Sadler PJ. Cadmium cyclam complexes: interconversion of cis and trans configurations and fixation of CO(2). Inorganic Chemistry. 41: 4539-47. PMID 12184772 DOI: 10.1021/ic0255050  1
2002 Wang F, Chen H, Parkinson JA, Murdoch Pdel S, Sadler PJ. Reactions of a ruthenium(II) arene antitumor complex with cysteine and methionine. Inorganic Chemistry. 41: 4509-23. PMID 12184769 DOI: 10.1021/ic025538f  1
2002 Liang X, Parkinson JA, Weishäupl M, Gould RO, Paisey SJ, Park HS, Hunter TM, Blindauer CA, Parsons S, Sadler PJ. Structure and dynamics of metallomacrocycles: recognition of zinc xylyl-bicyclam by an HIV coreceptor. Journal of the American Chemical Society. 124: 9105-12. PMID 12149014 DOI: 10.1021/ja0260723  1
2002 Zhong W, Parkinson JA, Guo M, Sadler PJ. Unusual features for zirconium(IV) binding to human serum transferrin. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 7: 589-99. PMID 12072964 DOI: 10.1007/s00775-001-0337-8  1
2002 Chen H, Parkinson JA, Parsons S, Coxall RA, Gould RO, Sadler PJ. Organometallic ruthenium(II) diamine anticancer complexes: arene-nucleobase stacking and stereospecific hydrogen-bonding in guanine adducts. Journal of the American Chemical Society. 124: 3064-82. PMID 11902898 DOI: 10.1021/ja017482e  1
2002 Djuran MI, Milinkovic SU, Habtemariam A, Parsons S, Sadler PJ. Crystal packing and hydrogen bonding in platinum(II) nucleotide complexes: X-ray crystal structure of [Pt(MeSCH(2)CH(2)SMe)(5'-GMP-N7)(2)].6H(2)O. Journal of Inorganic Biochemistry. 88: 268-73. PMID 11897340 DOI: 10.1016/S0162-0134(01)00351-8  0.4
2002 Bihari S, Smith PA, Parsons S, Sadler PJ. Stereoisomers of Mn(III) complexes of ethylenebis[(o-hydroxyphenyl)glycine] Inorganica Chimica Acta. 331: 310-317. DOI: 10.1016/S0020-1693(02)00690-4  1
2001 Blindauer CA, Harrison MD, Parkinson JA, Robinson AK, Cavet JS, Robinson NJ, Sadler PJ. A metallothionein containing a zinc finger within a four-metal cluster protects a bacterium from zinc toxicity. Proceedings of the National Academy of Sciences of the United States of America. 98: 9593-8. PMID 11493688 DOI: 10.1073/pnas.171120098  1
2001 Habtemariam A, Parkinson JA, Margiotta N, Hambley TW, Parsons S, Sadler PJ. Structure and dynamics of a platinum(II) aminophosphine complex and its nucleobase adducts Journal of the Chemical Society, Dalton Transactions. 362-372. DOI: 10.1039/b007670h  1
2000 Guo M, Sun H, Bihari S, Parkinson JA, Gould RO, Parsons S, Sadler PJ. Stereoselective formation of seven-coordinate titanium(IV) monomer and dimer complexes of ethylenebis(o-hydroxyphenyl)glycine. Inorganic Chemistry. 39: 206-15. PMID 11272527 DOI: 10.1021/ic990669a  1
2000 Parkinson JA, Chen Y, del Socorro Murdoch P, Guo Z, Berners-Price SJ, Brown T, Sadler PJ. Sequence-dependent bending of DNA induced by cisplatin: NMR structures of an A.T-rich 14-mer duplex. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 3636-44. PMID 11072829 DOI: 10.1002/1521-3765(20001002)6:19<3636::AID-CHEM3636>3.0.CO;2-W  1
2000 Ivanov AI, Parkinson JA, Cossins E, Woodrow J, Sadler PJ. Bathocuproine-assisted reduction of copper(II) by human albumin. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 5: 102-9. PMID 10766442 DOI: 10.1007/s007750050013  1
1999 Guo Z, Sadler PJ. Metals in Medicine. Angewandte Chemie (International Ed. in English). 38: 1512-1531. PMID 29711002 DOI: 10.1002/(SICI)1521-3773(19990601)38:11<1512::AID-ANIE1512>3.0.CO;2-Y  0.4
1999 Cox MC, Barnham KJ, Frenkiel TA, Hoeschele JD, Mason AB, He QY, Woodworth RC, Sadler PJ. Identification of platination sites on human serum transferrin using (13)C and (15)N NMR spectroscopy. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 4: 621-31. PMID 10550692 DOI: 10.1007/s007750050386  1
1999 Sun H, Li H, Harvey I, Sadler PJ. Interactions of bismuth complexes with metallothionein(II). The Journal of Biological Chemistry. 274: 29094-101. PMID 10506163 DOI: 10.1074/jbc.274.41.29094  0.4
1999 Murdoch Pdel S, Guo Z, Parkinson JA, Sadler PJ. Kinetics of formation and stability of [Pt(dien)]2+ complexes with octamer and 14-mer DNA oligonucleotides containing a GG sequence. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 4: 32-8. PMID 10499100 DOI: 10.1007/s007750050286  0.4
1998 Sun H, Li H, Weir RA, Sadler PJ. The First Specific Ti -Protein Complex: Potential Relevance to Anticancer Activity of Titanocenes. Angewandte Chemie (International Ed. in English). 37: 1577-1579. PMID 29710917 DOI: 10.1002/(SICI)1521-3773(19980619)37:11<1577::AID-ANIE1577>3.0.CO;2-M  0.4
1998 Bloch C, Patel SU, Baud F, Zvelebil MJ, Carr MD, Sadler PJ, Thornton JM. 1H NMR structure of an antifungal gamma-thionin protein SIalpha1: similarity to scorpion toxins. Proteins. 32: 334-49. PMID 9715910 DOI: 10.1002/(SICI)1097-0134(19980815)32:3<334::AID-PROT9>3.0.CO;2-H  1
1998 Viles JH, Patel SU, Mitchell JB, Moody CM, Justice DE, Uppenbrink J, Doyle PM, Harris CJ, Sadler PJ, Thornton JM. Design, synthesis and structure of a zinc finger with an artificial beta-turn. Journal of Molecular Biology. 279: 973-86. PMID 9642075 DOI: 10.1006/jmbi.1998.1764  1
1998 Guo Z, Habtemariam A, Sadler PJ, James BR. Chelate ring-opening ruthenium complexes: X-ray crystal structure and solution studies of cis, trans-bis(2-dimethyl-aminoethyl)-diphenyl-phosphino(dichloro)ruthenium(II) Inorganica Chimica Acta. 273: 1-7. DOI: 10.1016/S0020-1693(97)05911-2  0.4
1997 Reeder F, Guo Z, Murdoch PDS, Corazza A, Hambley TW, Berners-Price SJ, Chottard JC, Sadler PJ. Platination of a GG site on single-stranded and double-stranded forms of a 14-base oligonucleotide with diaqua cisplatin followed by NMR and HPLC. Influence of the platinum ligands and base sequence on 5'-G versus 3'-G platination selectivity European Journal of Biochemistry. 249: 370-382. PMID 9370343 DOI: 10.1111/j.1432-1033.1997.00370.x  1
1996 Jones DT, Moody CM, Uppenbrink J, Viles JH, Doyle PM, Harris CJ, Pearl LH, Sadler PJ, Thornton JM. Towards meeting the Paracelsus Challenge: The design, synthesis, and characterization of paracelsin-43, an alpha-helical protein with over 50% sequence identity to an all-beta protein. Proteins. 24: 502-13. PMID 8859998 DOI: 10.1002/(SICI)1097-0134(199604)24:4<502::AID-PROT9>3.0.CO;2-F  1
1996 Doyle PM, Harris JC, Moody CM, Sadler PJ, Sims M, Thornton JM, Uppenbrink J, Viles JH. Solution structure of a biologically active cyclic LDV peptide analogue containing a type II' beta-turn mimetic. International Journal of Peptide and Protein Research. 47: 427-36. PMID 8836770 DOI: 10.1111/j.1399-3011.1996.tb01093.x  1
1996 Harris R, Patel SU, Sadler PJ, Viles JH. Observation of albumin resonances in proton nuclear magnetic resonance spectra of human blood plasma: N-terminal assignments aided by use of modified recombinant albumin. The Analyst. 121: 913-22. PMID 8757924 DOI: 10.1039/an9962100913  1
1995 Kubal G, Meyer DJ, Norman RE, Sadler PJ. Investigations of glutathione conjugation in vitro by 1H NMR spectroscopy. Uncatalyzed and glutathione transferase-catalyzed reactions Chemical Research in Toxicology. 8: 780-791. PMID 7548762 DOI: 10.1021/tx00047a019  1
1994 Bal W, Djuran MI, Margerum DW, Gray ET, Mazid MA, Tom RT, Nieboer E, Sadler PJ. Dioxygen-induced decarboxylation and hydroxylation of [Ni II(glycyl-glycyl-L-histidine)] occurs via NiIII: X-ray crystal structure of [NiII(glycyl-glycyl-α-hydroxy-D,L- histamine)]·3H2O Journal of the Chemical Society, Chemical Communications. 1889-1890. DOI: 10.1039/C39940001889  1
1993 Lodge JK, Patel SU, Sadler PJ. Aldehydes from metal ion- and lipoxygenase-induced lipid peroxidation: detection by 1H-n.m.r. spectroscopy. The Biochemical Journal. 289: 149-53. PMID 8380981 DOI: 10.1042/bj2890149  1
1993 Ranford JD, Sadler PJ, Tocher DA. Cytotoxicity and antiviral activity of transition-metal salicylato complexes and crystal structure of Bis(diisopropylsalicylato)(1,10-phenanthroline)copper(II) Journal of the Chemical Society, Dalton Transactions. 3393-3399. DOI: 10.1039/DT9930003393  1
1992 Rhodes MD, Sadler PJ, Scawen MD, Silver S. Effects of gold(I) antiarthritic drugs and related compounds on Pseudomonas putida. Journal of Inorganic Biochemistry. 46: 129-42. PMID 1355789 DOI: 10.1016/0162-0134(92)80016-O  1
1991 Bell JD, Sadler PJ, Morris VC, Levander OA. Effect of aging and diet on proton NMR spectra of rat urine. Magnetic Resonance in Medicine. 17: 414-22. PMID 1829498 DOI: 10.1002/mrm.1910170213  1
1989 Bell JD, Brown JC, Sadler PJ. NMR studies of body fluids Nmr in Biomedicine. 2: 246-256. PMID 2701808 DOI: 10.1002/nbm.1940020513  1
1988 Bell JD, Brown JCC, Kubal G, Sadler PJ. NMR-invisible lactate in blood plasma Febs Letters. 235: 81-86. PMID 3402603 DOI: 10.1016/0014-5793(88)81238-9  1
1988 Bales JR, Bell JD, Nicholson JK, Sadler PJ, Timbrell JA, Hughes RD, Bennett PN, Williams R. Metabolic profiling of body fluids by proton NMR: Self-poisoning episodes with paracetamol (acetaminophen) Magnetic Resonance in Medicine. 6: 300-306. PMID 3362065 DOI: 10.1002/mrm.1910060308  1
1987 Bell JD, Norman RE, Sadler PJ. Coordination chemistry in biological media: reactions of antitumor Pt(II) and Au(III) complexes with cell culture media Journal of Inorganic Biochemistry. 31: 241-246. PMID 3437278 DOI: 10.1016/0162-0134(87)80078-8  1
1987 Nicholson JK, Sadler PJ, Vasák M. Probing the reactivity of the zinc and cadmium ions bound to rabbit liver metallothioneins with EDTA Experientia. Supplementum. 52: 191-201. PMID 2959505 DOI: 10.1007/978-3-0348-6784-9_12  1
1987 Bell JD, Brown JCC, Nicholson JK, Sadler PJ. Assignment of resonances for 'acute-phase' glycoproteins in high resolution proton NMR spectra of human blood plasma Febs Letters. 215: 311-315. PMID 2438159 DOI: 10.1016/0014-5793(87)80168-0  1
1986 Bales JR, Bell JD, Nicholson JK, Sadler PJ. 1H NMR studies of urine during fasting: Excretion of ketone bodies and acetylcarnitine Magnetic Resonance in Medicine. 3: 849-856. PMID 2434822 DOI: 10.1002/mrm.1910030605  1
1985 Vašák M, Hawkes GE, Nicholson JK, Sadler PJ. 113Cd NMR studies of reconstituted seven-cadmium metallothionein: Evidence for structural flexibility Biochemistry. 24: 740-747. PMID 3994982 DOI: 10.1021/bi00324a031  1
1983 Nicholson JK, Buckingham MJ, Sadler PJ. High resolution 1H n.m.r. studies of vertebrate blood and plasma Biochemical Journal. 211: 605-615. PMID 6411064 DOI: 10.1042/bj2110605  1
1982 Buckingham MJ, Hawkes GE, Ismail IM, Sadler PJ. The resolution of chlorine and bromine isotope shifts in the <sup>31</sup>P nuclear magnetic resonance spectra of PCl<inf>3</inf> and PBr<inf>3</inf> Journal of the Chemical Society, Dalton Transactions. 1167-1168. DOI: 10.1039/DT9820001167  1
1978 Malik NA, Sadler PJ, Neidle S, Taylor GL. X-Ray crystal structure of sodium bis(N-methylhydantoinato)gold(I) tetrahydrate; a linear, planar complex of pharmacological interest stabilised by two nitrogen ligands Journal of the Chemical Society, Chemical Communications. 711-712. DOI: 10.1039/C39780000711  1
1976 Ford L, Hill HA, Mann BE, Sadler PJ, Williams RJ. Nuclear magnetic resonance spectroscopy of cobalt(II) porphyrin-quinone complexes. Biochimica Et Biophysica Acta. 430: 413-8. PMID 938641  0.52
1973 Barry CD, Hill HA, Mann BE, Sadler PJ, Williams RJ. Molecular structures of porphyrin complexes in solution. An 1H nuclear magnetic resonance spectroscopic investigation of the interaction between 2,4,7-trinitrofluorenone and nickel(II) and cobalt(II) mesoporphyrin IX dimethyl esters. Journal of the American Chemical Society. 95: 4545-51. PMID 4730662  0.52
Show low-probability matches.