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Year Citation  Score
2021 Huber T, Goldman O, Epstein AE, Stella G, Sakmar TP. Principles and Practice for SARS-CoV-2 Decontamination of N95 Masks with UV-C. Biophysical Journal. PMID 33675766 DOI: 10.1016/j.bpj.2021.02.039  0.6
2020 Ceraudo E, Horioka M, Mattheisen JM, Hitchman TD, Moore AR, Kazmi MA, Chi P, Chen Y, Sakmar TP, Huber T. Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling. The Journal of Biological Chemistry. PMID 33288675 DOI: 10.1074/jbc.RA120.015352  0.6
2020 Hitchman TD, Bayshtok G, Ceraudo E, Moore AR, Lee C, Jia R, Wang N, Pachai MR, Shoushtari AN, Francis JH, Guan Y, Chen J, Chang MT, Taylor BS, Sakmar TP, et al. Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33229459 DOI: 10.1158/1078-0432.CCR-20-2860  0.6
2020 Horioka M, Ceraudo E, Lorenzen E, Sakmar TP, Huber T. Purinergic Receptors Crosstalk with CCR5 to Amplify Ca Signaling. Cellular and Molecular Neurobiology. PMID 33216235 DOI: 10.1007/s10571-020-01002-1  0.6
2020 Horioka M, Huber T, Sakmar TP. Playing Tag with Your Favorite GPCR Using CRISPR. Cell Chemical Biology. 27: 642-644. PMID 32559501 DOI: 10.1016/J.Chembiol.2020.06.001  0.6
2019 van Husen LS, Schedin-Weiss S, Trung MN, Kazmi MA, Winblad B, Sakmar TP, Elsässer SJ, Tjernberg LO. Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products. Journal of Alzheimer's Disease : Jad. PMID 31609694 DOI: 10.3233/Jad-190898  0.48
2019 Lorenzen E, Dodig-Crnković T, Kotliar IB, Pin E, Ceraudo E, Vaughan RD, Uhlèn M, Huber T, Schwenk JM, Sakmar TP. Multiplexed analysis of the secretin-like GPCR-RAMP interactome. Science Advances. 5: eaaw2778. PMID 31555726 DOI: 10.1126/sciadv.aaw2778  0.6
2019 Gagnon L, Cao Y, Cho A, Sedki D, Huber T, Sakmar TP, Laporte SA. Genetic code expansion and photocross-linking identify different β-arrestin binding modes to the angiotensin II type 1 receptor. The Journal of Biological Chemistry. PMID 31530642 DOI: 10.1074/Jbc.Ra119.010324  0.6
2019 Rico CA, Berchiche YA, Horioka M, Peeler JC, Lorenzen E, Tian H, Kazmi MA, Fürstenberg A, Gaertner H, Hartley O, Sakmar TP, Huber T. High-Affinity Binding of Chemokine Analogs that Display Ligand Bias at the HIV-1 Coreceptor CCR5. Biophysical Journal. PMID 31421836 DOI: 10.1016/J.Bpj.2019.07.043  0.6
2019 Krause BS, Kaufmann JCD, Kuhne J, Vierock J, Huber T, Sakmar TP, Gerwert K, Bartl F, Hegemann P. Tracking pore hydration in channelrhodopsin by site-directed infrared-active azido probes. Biochemistry. PMID 30702875 DOI: 10.1021/Acs.Biochem.8B01211  0.6
2019 Huber T, Sakmar TP. Third-Party Capture of Elusive GPCR Dimers. Biophysical Journal. 116: 1-3. PMID 30558887 DOI: 10.1016/J.Bpj.2018.11.018  0.6
2018 Barbash S, Persson T, Lorenzen E, Kazmi MA, Huber T, Sakmar TP. Detection of Concordance between Transcriptional Levels of GPCRs and Receptor-Activity-Modifying Proteins. Iscience. 11: 366-374. PMID 30660104 DOI: 10.1016/J.Isci.2018.12.024  0.6
2018 Sakmar TP, Huber T. Ancient Family of Retinal Proteins Brought to Light "Sight-Unseen". Biochemistry. PMID 30499659 DOI: 10.1021/Acs.Biochem.8B01188  0.6
2018 Lorenzen E, Ceraudo E, Berchiche YA, Rico CA, Fürstenberg A, Sakmar TP, Huber T. G protein subtype-specific signaling bias in a series of CCR5 chemokine analogs. Science Signaling. 11. PMID 30327411 DOI: 10.1126/Scisignal.Aao6152  0.6
2018 Iric K, Subramanian M, Oertel J, Agarwal NP, Matthies M, Periole X, Sakmar TP, Huber T, Fahmy K, Schmidt TL. DNA-encircled lipid bilayers. Nanoscale. PMID 30272763 DOI: 10.1039/C8Nr06505E  0.6
2018 Huber T, Sakmar TP. Probing Antibody Binding Sites on G Protein-Coupled Receptors Using Genetically Encoded Photo-Activatable Cross-Linkers. Methods in Molecular Biology (Clifton, N.J.). 1785: 65-75. PMID 29714012 DOI: 10.1007/978-1-4939-7841-0_5  0.6
2017 Periole X, Huber T, Bonito-Oliva A, Aberg KC, van der Wel PCA, Sakmar TP, Marrink SJ. Energetics Underlying Twist Polymorphisms in Amyloid Fibrils. The Journal of Physical Chemistry. B. PMID 29254334 DOI: 10.1021/Acs.Jpcb.7B10233  0.6
2017 Peeler JC, Schedin-Weiss S, Soula M, Kazmi MA, Sakmar TP. Isopeptide and ester bond ubiquitination both regulate degradation of the human dopamine receptor 4. The Journal of Biological Chemistry. PMID 29101232 DOI: 10.1074/Jbc.M116.758961  0.48
2017 Barbash S, Lorenzen E, Persson T, Huber T, Sakmar TP. GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078385 DOI: 10.1073/Pnas.1713074114  0.6
2017 Tian H, Sakmar TP, Huber T. The Energetics of Chromophore Binding in the Visual Photoreceptor Rhodopsin. Biophysical Journal. 113: 60-72. PMID 28700926 DOI: 10.1016/J.Bpj.2017.05.036  0.6
2017 Tian H, Sakmar TP, Huber T. Measurement of Slow Spontaneous Release of 11-cis-Retinal from Rhodopsin. Biophysical Journal. 112: 153-161. PMID 28076806 DOI: 10.1016/J.Bpj.2016.12.005  0.6
2016 Sakmar TP, Huber T. Pharmacology: Inside-out receptor inhibition. Nature. PMID 27926728 DOI: 10.1038/Nature20486  0.6
2016 Berchiche YA, Sakmar TP. CXC Chemokine Receptor 3 Alternative Splice Variants Selectively Activate Different Signaling Pathways. Molecular Pharmacology. PMID 27512119 DOI: 10.1124/Mol.116.105502  0.92
2016 Rannversson H, Andersen J, Sørensen L, Bang-Andersen B, Park M, Huber T, Sakmar TP, Strømgaard K. Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter. Nature Communications. 7: 11261. PMID 27089947 DOI: 10.1038/Ncomms11261  0.6
2016 Moore AR, Ceraudo E, Sher JJ, Guan Y, Shoushtari AN, Chang MT, Zhang JQ, Walczak EG, Kazmi MA, Taylor BS, Huber T, Chi P, Sakmar TP, Chen Y. Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma. Nature Genetics. PMID 27089179 DOI: 10.1038/Ng.3549  0.92
2016 Tian H, Sakmar TP, Huber T. A simple method for enhancing the bioorthogonality of cyclooctyne reagent. Chemical Communications (Cambridge, England). PMID 27009873 DOI: 10.1039/C6Cc01321J  0.92
2016 Seibert C, Sanfiz A, Sakmar TP, Veldkamp CT. Preparation and Analysis of N-Terminal Chemokine Receptor Sulfopeptides Using Tyrosylprotein Sulfotransferase Enzymes. Methods in Enzymology. 570: 357-88. PMID 26921955 DOI: 10.1016/Bs.Mie.2015.09.004  0.92
2015 Park M, Sivertsen BB, Els-Heindl S, Huber T, Holst B, Beck-Sickinger AG, Schwartz TW, Sakmar TP. Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics. Chemistry & Biology. PMID 26548612 DOI: 10.1016/J.Chembiol.2015.09.014  0.92
2015 Park M, Tian H, Naganathan S, Sakmar TP, Huber T. Quantitative Multi-color Detection Strategies for Bioorthogonally Labeled GPCRs. Methods in Molecular Biology (Clifton, N.J.). 1335: 67-93. PMID 26260595 DOI: 10.1007/978-1-4939-2914-6_6  0.92
2015 Tian H, Sakmar TP, Huber T. Micelle-Enhanced Bioorthogonal Labeling of Genetically Encoded Azido Groups on the Lipid-Embedded Surface of a GPCR. Chembiochem : a European Journal of Chemical Biology. 16: 1314-22. PMID 25962668 DOI: 10.1002/Cbic.201500030  0.6
2015 Naganathan S, Ray-Saha S, Park M, Tian H, Sakmar TP, Huber T. Multiplex detection of functional G protein-coupled receptors harboring site-specifically modified unnatural amino acids. Biochemistry. 54: 776-86. PMID 25524496 DOI: 10.1021/Bi501267X  0.92
2015 Staljanssens D, Rico CA, Park M, Van Camp J, Yu N, Huber T, Sakmar TP, Smagghe G. Development of a CCK1R-membrane nanoparticle as a fish-out tool for bioactive peptides. Peptides. 68: 219-27. PMID 25451329 DOI: 10.1016/J.Peptides.2014.10.015  0.6
2015 Staljanssens D, Rico CA, Park M, Van Camp J, Yu N, Huber T, Sakmar TP, Agghe G. Development of a CCK1R-membrane nanoparticle as a fish-out tool for bioactive peptides Peptides. 68: 219-227. DOI: 10.1016/j.peptides.2014.10.015  0.92
2015 Tian H, Sakmar TP, Huber T. Micelle-enhanced bioorthogonal labeling of genetically encoded azido groups on the lipid-embedded surface of a GPCR Chembiochem. 16: 1314-1322. DOI: 10.1002/cbic.201500030  0.92
2014 Huber T, Sakmar TP. Chemical biology methods for investigating G protein-coupled receptor signaling Chemistry and Biology. 21: 1224-1237. PMID 25237865 DOI: 10.1016/J.Chembiol.2014.08.009  0.92
2014 Tian H, Naganathan S, Kazmi MA, Schwartz TW, Sakmar TP, Huber T. Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors. Chembiochem : a European Journal of Chemical Biology. 15: 1820-9. PMID 25045132 DOI: 10.1002/Cbic.201402193  0.92
2014 Valentin-Hansen L, Park M, Huber T, Grunbeck A, Naganathan S, Schwartz TW, Sakmar TP. Mapping Substance P binding sites on the neurokinin-1 receptor using genetic incorporation of a photoreactive amino acid Journal of Biological Chemistry. 289: 18045-18054. PMID 24831006 DOI: 10.1074/Jbc.M113.527085  0.92
2014 Ray-Saha S, Huber T, Sakmar TP. Antibody epitopes on G protein-coupled receptors mapped with genetically encoded photoactivatable cross-linkers Biochemistry. 53: 1302-1310. PMID 24490954 DOI: 10.1021/Bi401289P  0.92
2013 Sekharan S, Mooney VL, Rivalta I, Kazmi MA, Neitz M, Neitz J, Sakmar TP, Yan EC, Batista VS. Spectral tuning of ultraviolet cone pigments: an interhelical lock mechanism. Journal of the American Chemical Society. 135: 19064-7. PMID 24295328 DOI: 10.1021/Ja409896Y  0.92
2013 Grunbeck A, Sakmar TP. Probing G protein-coupled receptor-ligand interactions with targeted photoactivatable cross-linkers. Biochemistry. 52: 8625-32. PMID 24199838 DOI: 10.1021/Bi401300Y  0.32
2013 Tian H, Sakmar TP, Huber T. Site-Specific Labeling of Genetically Encoded Azido Groups for Multicolor, Single-Molecule Fluorescence Imaging of GPCRs Methods in Cell Biology. 117: 267-303. PMID 24143983 DOI: 10.1016/B978-0-12-408143-7.00015-3  0.92
2013 Naganathan S, Grunbeck A, Tian H, Huber T, Sakmar TP. Genetically-encoded molecular probes to study G protein-coupled receptors. Journal of Visualized Experiments : Jove. PMID 24056801 DOI: 10.3791/50588  0.92
2013 Berro R, Yasmeen A, Abrol R, Trzaskowski B, Abi-Habib S, Grunbeck A, Lascano D, Goddard WA, Klasse PJ, Sakmar TP, Moore JP. Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants Journal of Virology. 87: 6569-6581. PMID 23468486 DOI: 10.1128/Jvi.00099-13  0.92
2013 Knepp AM, Sakmar TP, Huber T. Homogeneous time-resolved fluorescence assay to probe folded G protein-coupled receptors Methods in Enzymology. 522: 169-189. PMID 23374186 DOI: 10.1016/B978-0-12-407865-9.00010-8  0.92
2013 Grunbeck A, Huber T, Sakmar TP. Mapping a ligand binding site using genetically encoded photoactivatable crosslinkers Methods in Enzymology. 520: 307-322. PMID 23332706 DOI: 10.1016/B978-0-12-391861-1.00014-9  0.92
2013 Huber T, Naganathan S, Tian H, Ye S, Sakmar TP. Unnatural amino acid mutagenesis of GPCRs using amber codon suppression and bioorthogonal labeling Methods in Enzymology. 520: 281-305. PMID 23332705 DOI: 10.1016/B978-0-12-391861-1.00013-7  0.92
2013 Naganathan S, Ye S, Sakmar TP, Huber T. Site-specific epitope tagging of G protein-coupled receptors by bioorthogonal modification of a genetically encoded unnatural amino acid Biochemistry. 52: 1028-1036. PMID 23317030 DOI: 10.1021/Bi301292H  0.92
2013 Grunbeck A, Sakmar TP. Probing G protein-coupled receptor - Ligand interactions with targeted photoactivatable cross-linkers Biochemistry. 52: 8625-8632. DOI: 10.1021/bi401300y  0.92
2012 Sakmar TP. Redder than red Science. 338: 1299-1300. PMID 23224543 DOI: 10.1126/Science.1231589  0.92
2012 Periole X, Knepp AM, Sakmar TP, Marrink SJ, Huber T. Structural determinants of the supramolecular organization of G protein-coupled receptors in bilayers Journal of the American Chemical Society. 134: 10959-10965. PMID 22679925 DOI: 10.1021/Ja303286E  0.92
2012 Gupta R, Kapoor N, Raleigh DP, Sakmar TP. Nucleobindin 1 caps human islet amyloid polypeptide protofibrils to prevent amyloid fibril formation Journal of Molecular Biology. 421: 378-389. PMID 22542527 DOI: 10.1016/J.Jmb.2012.04.017  0.92
2012 Grunbeck A, Huber T, Abrol R, Trzaskowski B, Goddard WA, Sakmar TP. Genetically encoded photo-cross-linkers map the binding site of an allosteric drug on a G protein-coupled receptor Acs Chemical Biology. 7: 967-972. PMID 22455376 DOI: 10.1021/Cb300059Z  0.92
2012 Knepp AM, Periole X, Marrink SJ, Sakmar TP, Huber T. Rhodopsin forms a dimer with cytoplasmic helix 8 contacts in native membranes Biochemistry. 51: 1819-1821. PMID 22352709 DOI: 10.1021/Bi3001598  0.92
2012 Sakmar TP. Har Gobind Khorana (1922-2011): chemical biology pioneer. Acs Chemical Biology. 7: 250-251. PMID 22339934 DOI: 10.1021/cb3000293  0.92
2012 Ernst OP, Sakmar TP. Structural biology: Ion channel in the spotlight Nature. 482: 318-319. PMID 22337049 DOI: 10.1038/482318a  0.92
2012 Sakmar TP. Har Gobind Khorana (1922-2011): Pioneering spirit Plos Biology. 10. DOI: 10.1371/journal.pbio.1001273  0.92
2012 Siderius M, Wal M, Scholten DJ, Smit MJ, Sakmar TP, Leurs R, De Graaf C. Unnatural amino acids for the study of chemokine receptor structure and dynamics Drug Discovery Today: Technologies. 9: e301-e313. DOI: 10.1016/J.Ddtec.2012.07.008  0.92
2012 Farrens DL, Sakmar TP. Contributions of H G Khorana to understanding transmembrane signal transduction Resonance. 17: 1165-1173. DOI: 10.1007/S12045-012-0133-5  0.92
2011 Schwartz TW, Sakmar TP. Structural biology: Snapshot of a signalling complex Nature. 477: 540-541. PMID 21956322 DOI: 10.1038/477540a  0.92
2011 Janz JM, Ren Y, Looby R, Kazmi MA, Sachdev P, Grunbeck A, Haggis L, Chinnapen D, Lin AY, Seibert C, McMurry T, Carlson KE, Muir TW, Hunt S, Sakmar TP. Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4. Journal of the American Chemical Society. 133: 15878-81. PMID 21905700 DOI: 10.1021/Ja206661W  0.92
2011 Sakmar TP. Receptors: Clicking class B GPCR ligands Nature Chemical Biology. 7: 500-501. PMID 21769095 DOI: 10.1038/nchembio.621  0.92
2011 Décaillot FM, Kazmi MA, Lin Y, Ray-Saha S, Sakmar TP, Sachdev P. CXCR7/CXCR4 heterodimer constitutively recruits β-arrestin to enhance cell migration Journal of Biological Chemistry. 286: 32188-32197. PMID 21730065 DOI: 10.1074/jbc.M111.277038  0.92
2011 Berro R, Klasse PJ, Lascano D, Flegler A, Nagashima KA, Sanders RW, Sakmar TP, Hope TJ, Moore JP. Multiple CCR5 conformations on the cell surface are used differentially by human immunodeficiency viruses resistant or sensitive to CCR5 inhibitors. Journal of Virology. 85: 8227-40. PMID 21680525 DOI: 10.1128/JVI.00767-11  0.92
2011 Dimond P, Carlson K, Bouvier M, Gerard C, Xu L, Covic L, Agarwal A, Ernst OP, Janz JM, Schwartz TW, Gardella TJ, Milligan G, Kuliopulos A, Sakmar TP, Hunt SW. G protein-coupled receptor modulation with pepducins: moving closer to the clinic. Annals of the New York Academy of Sciences. 1226: 34-49. PMID 21615752 DOI: 10.1111/J.1749-6632.2011.06039.X  0.92
2011 Daggett KA, Sakmar TP. Site-specific in vitro and in vivo incorporation of molecular probes to study G-protein-coupled receptors Current Opinion in Chemical Biology. 15: 392-398. PMID 21571577 DOI: 10.1016/j.cbpa.2011.03.010  0.92
2011 Huber T, Sakmar TP. Escaping the flatlands: New approaches for studying the dynamic assembly and activation of GPCR signaling complexes Trends in Pharmacological Sciences. 32: 410-419. PMID 21497404 DOI: 10.1016/j.tips.2011.03.004  0.92
2011 Grunbeck A, Huber T, Sachdev P, Sakmar TP. Mapping the ligand-binding site on a G protein-coupled receptor (GPCR) using genetically encoded photocrosslinkers Biochemistry. 50: 3411-3413. PMID 21417335 DOI: 10.1021/Bi200214R  0.92
2011 Menon I, Huber T, Sanyal S, Banerjee S, Barré P, Canis S, Warren JD, Hwa J, Sakmar TP, Menon AK. Opsin is a phospholipid flippase. Current Biology : Cb. 21: 149-53. PMID 21236677 DOI: 10.1016/j.cub.2010.12.031  0.92
2011 Knepp AM, Grunbeck A, Banerjee S, Sakmar TP, Huber T. Direct measurement of thermal stability of expressed CCR5 and stabilization by small molecule ligands Biochemistry. 50: 502-511. PMID 21155586 DOI: 10.1021/Bi101059W  0.92
2010 Hou HJM, Sakmar TP. Methodology of pulsed photoacoustics and its application to probe photosystems and receptors Sensors. 10: 5642-5667. PMID 22219680 DOI: 10.3390/S100605642  0.92
2010 Tchernychev B, Ren Y, Sachdev P, Janz JM, Haggis L, O'Shea A, McBride E, Looby R, Deng Q, McMurry T, Kazmi MA, Sakmar TP, Hunt S, Carlson KE. Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells Proceedings of the National Academy of Sciences of the United States of America. 107: 22255-22259. PMID 21139054 DOI: 10.1073/Pnas.1009633108  0.92
2010 Zaitseva E, Saavedra M, Banerjee S, Sakmar TP, Vogel R. SEIRA spectroscopy on a membrane receptor monolayer using lipoprotein particles as carriers Biophysical Journal. 99: 2327-2335. PMID 20923668 DOI: 10.1016/j.bpj.2010.06.054  0.92
2010 Kapoor N, Gupta R, Menon ST, Folta-Stogniew E, Raleigh DP, Sakmar TP. Nucleobindin 1 is a calcium-regulated guanine nucleotide dissociation inhibitor of G{alpha}i1. The Journal of Biological Chemistry. 285: 31647-60. PMID 20679342 DOI: 10.1074/Jbc.M110.148429  0.92
2010 Ye S, Zaitseva E, Caltabiano G, Schertler GFX, Sakmar TP, Deupi X, Vogel R. Tracking G-protein-coupled receptor activation using genetically encoded infrared probes Nature. 464: 1386-1389. PMID 20383122 DOI: 10.1038/Nature08948  0.92
2010 Sakmar T. Seeing the signal Biotechniques. 49: 779. DOI: 10.2144/000113534  0.92
2010 Sakmar TP. Structure and function of g-protein-coupled receptors. lessons from recent crystal structures Handbook of Cell Signaling, 2/E. 1: 151-156. DOI: 10.1016/B978-0-12-374145-5.00023-1  0.92
2010 Sakmar TP. Examining receptor activation: New technologies reveal how G protein-coupled receptors recognise ligands and talk to intracellular partners European Pharmaceutical Review 0.92
2009 Ahuja S, Eilers M, Hirshfeld A, Yan ECY, Ziliox M, Sakmar TP, Sheves M, Smith SO. 6-s-cis conformation and polar binding pocket of the retinal chromophore in the photoactivated state of rhodopsin Journal of the American Chemical Society. 131: 15160-15169. PMID 19795853 DOI: 10.1021/Ja9034768  0.92
2009 Kapoor N, Menon ST, Chauhan R, Sachdev P, Sakmar TP. Structural Evidence for a Sequential Release Mechanism for Activation of Heterotrimeric G Proteins Journal of Molecular Biology. 393: 882-897. PMID 19703466 DOI: 10.1016/J.Jmb.2009.08.043  0.92
2009 Ye S, Huber T, Vogel R, Sakmar TP. FTIR analysis of GPCR activation using azido probes Nature Chemical Biology. 5: 397-399. PMID 19396177 DOI: 10.1038/Nchembio.167  0.92
2009 Ahuja S, Hornak V, Yan ECY, Syrett N, Goncalves JA, Hirshfeld A, Ziliox M, Sakmar TP, Sheves M, Reeves PJ, Smith SO, Eilers M. Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation Nature Structural and Molecular Biology. 16: 168-175. PMID 19182802 DOI: 10.1038/Nsmb.1549  0.92
2008 Seibert C, Veldkamp CT, Peterson FC, Chait BT, Volkman BF, Sakmar TP. Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases Biochemistry. 47: 11251-11262. PMID 18834145 DOI: 10.1021/bi800965m  0.92
2008 Huber T, Menon S, Sakmar TP. Structural basis for ligand binding and specificity in adrenergic receptors: Implications for GPCR-targeted drug discovery Biochemistry. 47: 11013-11023. PMID 18821775 DOI: 10.1021/Bi800891R  0.92
2008 Veldkamp CT, Seibert C, Peterson FC, De La Cruz NB, Haugner JC, Basnet H, Sakmar TP, Volkman BF. Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12 Science Signaling. 1. PMID 18799424 DOI: 10.1126/scisignal.1160755  0.92
2008 Vogel R, Mahalingam M, Lüdeke S, Huber T, Siebert F, Sakmar TP. Functional role of the "ionic lock"--an interhelical hydrogen-bond network in family A heptahelical receptors. Journal of Molecular Biology. 380: 648-55. PMID 18554610 DOI: 10.1016/j.jmb.2008.05.022  0.92
2008 Huber T, Sakmar TP. Rhodopsin's active state is frozen like a DEER in the headlights Proceedings of the National Academy of Sciences of the United States of America. 105: 7343-7344. PMID 18492801 DOI: 10.1073/pnas.0804122105  0.92
2008 Banerjee S, Huber T, Sakmar TP. Rapid Incorporation of Functional Rhodopsin into Nanoscale Apolipoprotein Bound Bilayer (NABB) Particles Journal of Molecular Biology. 377: 1067-1081. PMID 18313692 DOI: 10.1016/j.jmb.2008.01.066  0.92
2008 Louis M, Huber T, Benton R, Sakmar TP, Vosshall LB. Bilateral olfactory sensory input enhances chemotaxis behavior. Nature Neuroscience. 11: 187-99. PMID 18157126 DOI: 10.1038/nn2031  0.92
2008 Ye S, Köhrer C, Huber T, Kazmi M, Sachdev P, Yan EC, Bhagat A, RajBhandary UL, Sakmar TP. Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis. The Journal of Biological Chemistry. 283: 1525-33. PMID 17993461 DOI: 10.1074/Jbc.M707355200  0.92
2008 Seibert C, Sakmar TP. Toward a framework for sulfoproteomics: Synthesis and characterization of sulfotyrosine-containing peptides Biopolymers - Peptide Science Section. 90: 459-477. PMID 17680702 DOI: 10.1002/bip.20821  0.92
2007 Periole X, Huber T, Marrink SJ, Sakmar TP. G protein-coupled receptors self-assemble in dynamics simulations of model bilayers Journal of the American Chemical Society. 129: 10126-10132. PMID 17658882 DOI: 10.1021/ja0706246  0.92
2007 Janz JM, Sakmar TP, Min KC. A novel interaction between atrophin-interacting protein 4 and β-p21-activated kinase-interactive exchange factor is mediated by an SH3 domain Journal of Biological Chemistry. 282: 28893-28903. PMID 17652093 DOI: 10.1074/Jbc.M702678200  0.92
2007 Vogel R, Sakmar TP, Sheves M, Siebert F. Coupling of protonation switches during rhodopsin activation. Photochemistry and Photobiology. 83: 286-92. PMID 17576345 DOI: 10.1562/2006-06-19-IR-937  0.92
2007 Sachdev P, Menon S, Kastner DB, Chuang JZ, Yeh TY, Conde C, Caceres A, Sung CH, Sakmar TP. G protein beta gamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth. The Embo Journal. 26: 2621-32. PMID 17491591 DOI: 10.1038/Sj.Emboj.7601716  0.92
2007 Yan ECY, Epps J, Lewis JW, Szundi I, Bhagat A, Sakmar TP, Kliger DS. Photointermediates of the rhodopsin S186A mutant as a probe of the hydrogen-bond network in the chromophore pocket and the mechanism of counterion switch Journal of Physical Chemistry C. 111: 8843-8848. DOI: 10.1021/Jp067172O  0.92
2006 Botelho AV, Huber T, Sakmar TP, Brown MF. Curvature and Hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes Biophysical Journal. 91: 4464-4477. PMID 17012328 DOI: 10.1529/biophysj.106.082776  0.92
2006 Vogel R, Siebert F, Yan EC, Sakmar TP, Hirshfeld A, Sheves M. Modulating rhodopsin receptor activation by altering the pKa of the retinal Schiff base. Journal of the American Chemical Society. 128: 10503-12. PMID 16895417 DOI: 10.1021/Ja0627848  0.92
2006 Sakmar TP. Timing is everything: Direct measurement of retinol production in cones and rods Journal of General Physiology. 128: 147-148. PMID 16847095 DOI: 10.1085/jgp.200609609  0.92
2006 Veldkamp CT, Seibert C, Peterson FC, Sakmar TP, Volkman BF. Recognition of a CXCR4 Sulfotyrosine by the Chemokine Stromal Cell-derived Factor-1α (SDF-1α/CXCL12) Journal of Molecular Biology. 359: 1400-1409. PMID 16725153 DOI: 10.1016/j.jmb.2006.04.052  0.92
2006 Lewis JW, Szundi I, Kazmi MA, Sakmar TP, Kliger DS. Proton movement and photointermediate kinetics in rhodopsin mutants. Biochemistry. 45: 5430-9. PMID 16634624 DOI: 10.1021/Bi0525775  0.92
2006 Su CY, Luo DG, Terakita A, Shichida Y, Liao HW, Kazmi MA, Sakmar TP, Yau KW. Parietal-eye phototransduction components and their potential evolutionary implications. Science (New York, N.Y.). 311: 1617-21. PMID 16543463 DOI: 10.1126/science.1123802  0.92
2006 Hoelz A, Janz JM, Lawrie SD, Corwin B, Lee A, Sakmar TP. Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2. Journal of Molecular Biology. 358: 509-22. PMID 16527308 DOI: 10.1016/J.Jmb.2006.02.027  0.92
2006 Seibert C, Ying W, Gavrilov S, Tsamis F, Kuhmann SE, Palani A, Tagat JR, Clader JW, McCombie SW, Baroudy BM, Smith SO, Dragic T, Moore JP, Sakmar TP. Interaction of small molecule inhibitors of HIV-1 entry with CCR5 Virology. 349: 41-54. PMID 16494916 DOI: 10.1016/j.virol.2006.01.018  0.92
2006 Vogel R, Lüdeke S, Siebert F, Sakmar TP, Hirshfeld A, Sheves M. Agonists and partial agonists of rhodopsin: retinal polyene methylation affects receptor activation. Biochemistry. 45: 1640-52. PMID 16460011 DOI: 10.1021/Bi052196R  0.92
2005 Lüdeke S, Beck M, Yan EC, Sakmar TP, Siebert F, Vogel R. The role of Glu181 in the photoactivation of rhodopsin. Journal of Molecular Biology. 353: 345-56. PMID 16169009 DOI: 10.1016/J.Jmb.2005.08.039  0.92
2005 Huber T, Sakmar TP. The Photoreceptor Membrane as a Model System in the Study of Biological Signal Transduction Advances in Planar Lipid Bilayers and Liposomes. 1: 181-206. DOI: 10.1016/S1554-4516(05)01006-9  0.92
2005 Sakmar TP. Twenty years of the magnificent seven Scientist. 19: 22-23.  0.92
2004 Lewis JW, Szundi I, Kazmi MA, Sakmar TP, Kliger DS. Time-resolved photointermediate changes in rhodopsin glutamic acid 181 mutants. Biochemistry. 43: 12614-21. PMID 15449951 DOI: 10.1021/Bi049581L  0.92
2004 Yan ECY, Ganim Z, Kazmi MA, Chang BSW, Sakmar TP, Mathies RA. Resonance raman analysis of the mechanism of energy storage and chromophore distortion in the primary visual photoproduct Biochemistry. 43: 10867-10876. PMID 15323547 DOI: 10.1021/Bi0400148  0.92
2004 Seibert C, Sakmar TP. Small-molecule antagonists of CCR5 and CXCR4: A promising new class of anti-HIV-1 drugs Current Pharmaceutical Design. 10: 2041-2062. PMID 15279544 DOI: 10.2174/1381612043384312  0.92
2004 Billick E, Seibert C, Pugach P, Ketas T, Trkola A, Endres MJ, Murgolo NJ, Coates E, Reyes GR, Baroudy BM, Sakmar TP, Moore JP, Kuhmann SE. The Differential Sensitivity of Human and Rhesus Macaque CCR5 to Small-Molecule Inhibitors of Human Immunodeficiency Virus Type 1 Entry Is Explained by A Single Amino Acid Difference and Suggests A Mechanism of Action for These Inhibitors Journal of Virology. 78: 4134-4144. PMID 15047829 DOI: 10.1128/JVI.78.8.4134-4144.2004  0.92
2003 Yan ECY, Kazmi MA, Ganim Z, Hou JM, Pan D, Chang BSW, Sakmar TP, Mathies RA. Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin Proceedings of the National Academy of Sciences of the United States of America. 100: 9262-9267. PMID 12835420 DOI: 10.1073/Pnas.1531970100  0.92
2003 Tsamis F, Gavrilov S, Kajumo F, Seibert C, Kuhmann S, Ketas T, Trkola A, Palani A, Clader JW, Tagat JR, McCombie S, Baroudy B, Moore JP, Sakmar TP, Dragic T. Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry Journal of Virology. 77: 5201-5208. PMID 12692222 DOI: 10.1128/JVI.77.9.5201-5208.2003  0.92
2003 Sakmar TP. Structure and Function of G-Protein-Coupled Receptors: Lessons from the Crystal Structure of Rhodopsin Handbook of Cell Signaling. 1: 139-143. DOI: 10.1016/B978-012124546-7/50383-1  0.92
2002 Unson CG, Wu CR, Jiang Y, Yoo B, Cheung C, Sakmar TP, Merrifield RB. Roles of specific extracellular domains of the glucagon receptor in ligand binding and signaling. Biochemistry. 41: 11795-803. PMID 12269822 DOI: 10.1021/Bi025711J  0.92
2002 Chang BS, Jönsson K, Kazmi MA, Donoghue MJ, Sakmar TP. Recreating a functional ancestral archosaur visual pigment. Molecular Biology and Evolution. 19: 1483-9. PMID 12200476 DOI: 10.1093/Oxfordjournals.Molbev.A004211  0.92
2002 Seibert C, Cadene M, Sanfiz A, Chait BT, Sakmar TP. Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence Proceedings of the National Academy of Sciences of the United States of America. 99: 11031-11036. PMID 12169668 DOI: 10.1073/Pnas.172380899  0.92
2002 De Soma, Sakmar TP. Interaction of A2E with model membranes. Implications to the pathogenesis of age-related macular degeneration Journal of General Physiology. 120: 147-157. PMID 12149277 DOI: 10.1085/jgp.20028566  0.92
2002 Krishna AG, Menon ST, Terry TJ, Sakmar TP. Evidence that helix 8 of rhodopsin acts as a membrane-dependent conformational switch Biochemistry. 41: 8298-8309. PMID 12081478 DOI: 10.1021/Bi025534M  0.92
2002 Marin EP, Krishna AG, Sakmar TP. Disruption of the alpha5 helix of transducin impairs rhodopsin-catalyzed nucleotide exchange. Biochemistry. 41: 6988-94. PMID 12033931 DOI: 10.1021/Bi025514K  0.32
2002 Sakmar TP, Menon ST, Marin EP, Awad ES. Rhodopsin: Insights from recent structural studies Annual Review of Biophysics and Biomolecular Structure. 31: 443-484. PMID 11988478 DOI: 10.1146/annurev.biophys.31.082901.134348  0.92
2002 Sakmar TP. Structure of rhodopsin and the superfamily of seven-helical receptors: The same and not the same Current Opinion in Cell Biology. 14: 189-195. PMID 11891118 DOI: 10.1016/S0955-0674(02)00306-X  0.92
2002 Yan ECY, Kazmi MA, De S, Chang BSW, Seibert C, Marin EP, Mathies RA, Sakmar TP. Function of extracellular loop 2 in rhodopsin: Glutamic acid 181 modulates stability and absorption wavelength of metarhodopsin II Biochemistry. 41: 3620-3627. PMID 11888278 DOI: 10.1021/Bi0160011  0.92
2002 Marin EP, Krishna AG, Sakmar TP. Disruption of the α5 helix of transducin impairs rhodopsin-catalyzed nucleotide exchange Biochemistry. 41: 6988-6994. DOI: 10.1021/bi025514k  0.92
2002 Cadene M, Seibert C, Sakmar TP, Chait BT. Pattern and temporal sequence of tyrosine sulfation of HIV1 entry coreceptor CCR5 Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 301-302.  0.92
2001 Chang BSW, Kazmi MA, Sakmar TP. Synthetic gene technology: Applications to ancestral gene reconstruction and structure-function studies of receptors Methods in Enzymology. 343: 274-294. PMID 11665573 DOI: 10.1016/S0076-6879(02)43142-4  0.92
2001 Menon ST, Han M, Sakmar TP. Rhodopsin: Structural basis of molecular physiology Physiological Reviews. 81: 1659-1688. PMID 11581499  0.92
2001 Jiang Y, Cypess AM, Muse ED, Wu CR, Unson CG, Merrifield RB, Sakmar TP. Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 98: 10102-7. PMID 11517300 DOI: 10.1073/Pnas.131200398  0.92
2001 Marin EP, Krishna AG, Sakmar TP. Rapid activation of transducin by mutations distant from the nucleotide-binding site: Evidence for a mechanistic model of receptor-catalyzed nucleotide exchange by G proteins Journal of Biological Chemistry. 276: 27400-27405. PMID 11356823 DOI: 10.1074/jbc.C100198200  0.92
2001 Marin EP, Krishna AG, Archambault V, Simuni E, Fu WY, Sakmar TP. The function of interdomain interactions in controlling nucleotide exchange rates in transducin. The Journal of Biological Chemistry. 276: 23873-80. PMID 11290746 DOI: 10.1074/jbc.M101197200  0.92
2000 Isele J, Sakmar TP, Siebert F. Rhodopsin activation affects the environment of specific neighboring phospholipids: an FTIR spectroscopic study. Biophysical Journal. 79: 3063-71. PMID 11106612 DOI: 10.1016/S0006-3495(00)76541-6  0.92
2000 Min KC, Gravina SA, Sakmar TP. Reconstitution of the vertebrate visual cascade using recombinant heterotrimeric transducin purified from Sf9 cells. Protein Expression and Purification. 20: 514-26. PMID 11087692 DOI: 10.1006/prep.2000.1326  0.92
2000 Fahmy K, Sakmar TP, Siebert F. Transducin-dependent protonation of glutamic acid 134 in rhodopsin. Biochemistry. 39: 10607-12. PMID 10956053 DOI: 10.1021/Bi000912D  0.92
2000 Sakmar TP. Restoration of compact discs. Nature Genetics. 25: 245-6. PMID 10888860 DOI: 10.1038/76976  0.92
2000 Cormier EG, Persuh M, Thompson DA, Lin SW, Sakmar TP, Olson WC, Dragic T. Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120. Proceedings of the National Academy of Sciences of the United States of America. 97: 5762-7. PMID 10823934 DOI: 10.1073/Pnas.97.11.5762  0.92
2000 Unson CG, Wu CR, Sakmar TP, Merrifield RB. Selective stabilization of the high affinity binding conformation of glucagon receptor by the long splice variant of Galpha(s). The Journal of Biological Chemistry. 275: 21631-8. PMID 10791965 DOI: 10.1074/jbc.M002093200  0.92
2000 Dragic T, Trkola A, Thompson DA, Cormier EG, Kajumo FA, Maxwell E, Lin SW, Ying W, Smith SO, Sakmar TP, Moore JP. A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5. Proceedings of the National Academy of Sciences of the United States of America. 97: 5639-44. PMID 10779565 DOI: 10.1073/pnas.090576697  0.92
2000 Han M, Sakmar TP. Assays for activation of recombinant expressed opsins by all-trans-retinals. Methods in Enzymology. 315: 251-67. PMID 10736707 DOI: 10.1016/S0076-6879(00)15848-3  0.92
2000 Fahmy K, Sakmar TP, Siebert F. Structural determinants of active state conformation of rhodopsin: molecular biophysics approaches. Methods in Enzymology. 315: 178-96. PMID 10736702 DOI: 10.1016/S0076-6879(00)15843-4  0.92
2000 Lin SW, Han M, Sakmar TP. Analysis of functional microdomains of rhodopsin. Methods in Enzymology. 315: 116-30. PMID 10736698 DOI: 10.1016/S0076-6879(00)15839-2  0.92
2000 Kazmi MA, Snyder LA, Cypess AM, Graber SG, Sakmar TP. Selective reconstitution of human D4 dopamine receptor variants with Gi alpha subtypes. Biochemistry. 39: 3734-44. PMID 10736173 DOI: 10.1021/Bi992354C  0.92
2000 Lewis JW, Szundi I, Fu WY, Sakmar TP, Kliger DS. pH dependence of photolysis intermediates in the photoactivation of rhodopsin mutant E113Q. Biochemistry. 39: 599-606. PMID 10642185 DOI: 10.1021/Bi991860Z  0.92
2000 Ernst OP, Meyer CK, Marin EP, Henklein P, Fu WY, Sakmar TP, Hofmann KP. Mutation of the fourth cytoplasmic loop of rhodopsin affects binding of transducin and peptides derived from the carboxyl-terminal sequences of transducin alpha and gamma subunits. The Journal of Biological Chemistry. 275: 1937-43. PMID 10636895 DOI: 10.1074/jbc.275.3.1937  0.92
2000 Marin EP, Krishna AG, Zvyaga TA, Isele J, Siebert F, Sakmar TP. The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction. The Journal of Biological Chemistry. 275: 1930-6. PMID 10636894 DOI: 10.1074/jbc.275.3.1930  0.92
1999 Lin SW, Sakmar TP. Colour tuning mechanisms of visual pigments. Novartis Foundation Symposium. 224: 124-35; discussion 1. PMID 10614049  0.92
1999 Simpson MM, Ballesteros JA, Chiappa V, Chen J, Suehiro M, Hartman DS, Godel T, Snyder LA, Sakmar TP, Javitch JA. Dopamine D4/D2 receptor selectivity is determined by A divergent aromatic microdomain contained within the second, third, and seventh membrane-spanning segments. Molecular Pharmacology. 56: 1116-26. PMID 10570038 DOI: 10.1124/Mol.56.6.1116  0.92
1999 Sakmar TP. Rhodopsin early receptor potential revisited. Biophysical Journal. 77: 1189-91. PMID 10465733 DOI: 10.1016/S0006-3495(99)76970-5  0.92
1999 Kochendoerfer GG, Lin SW, Sakmar TP, Mathies RA. How color visual pigments are tuned. Trends in Biochemical Sciences. 24: 300-5. PMID 10431173 DOI: 10.1016/S0968-0004(99)01432-2  0.92
1999 Cypess AM, Unson CG, Wu CR, Sakmar TP. Two cytoplasmic loops of the glucagon receptor are required to elevate cAMP or intracellular calcium Journal of Biological Chemistry. 274: 19455-19464. PMID 10383462 DOI: 10.1074/jbc.274.27.19455  0.92
1998 Beck M, Siebert F, Sakmar TP. Evidence for the specific interaction of a lipid molecule with rhodopsin which is altered in the transition to the active state metarhodopsin II. Febs Letters. 436: 304-8. PMID 9801137 DOI: 10.1016/S0014-5793(98)01156-9  0.92
1998 Lin SW, Kochendoerfer GG, Carroll KS, Wang D, Mathies RA, Sakmar TP. Mechanisms of spectral tuning in blue cone visual pigments. Visible and raman spectroscopy of blue-shifted rhodopsin mutants. The Journal of Biological Chemistry. 273: 24583-91. PMID 9733753 DOI: 10.1074/Jbc.273.38.24583  0.92
1998 Han M, Smith SO, Sakmar TP. Constitutive activation of opsin by mutation of methionine 257 on transmembrane helix 6 Biochemistry. 37: 8253-8261. PMID 9609722 DOI: 10.1021/Bi980147R  0.92
1998 Beck M, Sakmar TP, Siebert F. Spectroscopic evidence for interaction between transmembrane helices 3 and 5 in rhodopsin. Biochemistry. 37: 7630-9. PMID 9585578 DOI: 10.1021/Bi9801560  0.92
1998 Sakmar TP. Rhodopsin: a prototypical G protein-coupled receptor Progress in Nucleic Acid Research and Molecular Biology. 59: 1-34. PMID 9427838  0.92
1998 Donzella GA, Schols D, Lin SW, Esté JA, Nagashima KA, Maddon PJ, Allaway GP, Sakmar TP, Henson G, De Clercq E, Moore JP. AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co- receptor Nature Medicine. 4: 72-77. PMID 9427609 DOI: 10.1038/nm0198-072  0.92
1998 Han M, Groesbeek M, Smith SO, Sakmar TP. Role of the C9 methyl group in rhodopsin activation: Characterization of mutant opsins with the artificial chromophore 11-cis-9-demethylretinal Biochemistry. 37: 538-545. PMID 9425074 DOI: 10.1021/Bi972060W  0.92
1998 Dragic T, Trkola A, Lin SW, Nagashima KA, Kajumo F, Zhao L, Olson WC, Wu L, Mackay CR, Allaway GP, Sakmar TP, Moore JP, Maddon PJ. Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry Journal of Virology. 72: 279-285. PMID 9420225  0.92
1997 Han M, Groesbeek M, Sakmar TP, Smith SO. The C9 methyl group of retinal interacts with glycine-121 in rhodopsin Proceedings of the National Academy of Sciences of the United States of America. 94: 13442-13447. PMID 9391044 DOI: 10.1073/Pnas.94.25.13442  0.92
1997 Jäger S, Han M, Lewis JW, Szundi I, Sakmar TP, Kliger DS. Properties of early photolysis intermediates of rhodopsin are affected by glycine 121 and phenylalanine 261. Biochemistry. 36: 11804-10. PMID 9305971 DOI: 10.1021/Bi971122F  0.92
1997 Han M, Lou J, Nakanishi K, Sakmar TP, Smith SO. Partial agonist activity of 11-cis-retinal in rhodopsin mutants Journal of Biological Chemistry. 272: 23081-23085. PMID 9287308 DOI: 10.1074/Jbc.272.37.23081  0.92
1997 Jäger S, Lewis JW, Zvyaga TA, Szundi I, Sakmar TP, Kliger DS. Chromophore structural changes in rhodopsin from nanoseconds to microseconds following pigment photolysis. Proceedings of the National Academy of Sciences of the United States of America. 94: 8557-62. PMID 9238015 DOI: 10.1073/Pnas.94.16.8557  0.92
1997 Shieh T, Han M, Sakmar TP, Smith SO. The steric trigger in rhodopsin activation Journal of Molecular Biology. 269: 373-384. PMID 9199406 DOI: 10.1006/jmbi.1997.1035  0.92
1997 Kazmi MA, Sakmar TP, Ostrer H. Mutation of a conserved cysteine in the X-linked cone opsins causes color vision deficiencies by disrupting protein folding and stability Investigative Ophthalmology and Visual Science. 38: 1074-1081. PMID 9152227  0.92
1997 Jäger S, Lewis JW, Zvyaga TA, Szundi I, Sakmar TP, Kliger DS. Time-resolved spectroscopy of the early photolysis intermediates of rhodopsin Schiff base counterion mutants. Biochemistry. 36: 1999-2009. PMID 9047297 DOI: 10.1021/Bi962320U  0.92
1996 Han M, Lin SW, Minkova M, Smith SO, Sakmar TP. Functional interaction of transmembrane helices 3 and 6 in rhodopsin. Replacement of phenylalanine 261 by alanine causes reversion of phenotype of a glycine 121 replacement mutant Journal of Biological Chemistry. 271: 32337-32342. PMID 8943296 DOI: 10.1074/jbc.271.50.32337  0.92
1996 Han M, Lin SW, Smith SO, Sakmar TP. The effects of amino acid replacements of glycine 121 on transmembrane helix 3 of rhodopsin Journal of Biological Chemistry. 271: 32330-32336. PMID 8943295 DOI: 10.1074/jbc.271.50.32330  0.92
1996 Fahmy K, Zvyaga TA, Sakmar TP, Siebert F. Spectroscopic evidence for altered chromophore--protein interactions in low-temperature photoproducts of the visual pigment responsible for congenital night blindness. Biochemistry. 35: 15065-73. PMID 8942673 DOI: 10.1021/Bi961486S  0.92
1996 Sheikh SP, Zvyaga TA, Lichtarge O, Sakmar TP, Bourne HR. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature. 383: 347-50. PMID 8848049 DOI: 10.1038/383347A0  0.92
1996 Lin SW, Sakmar TP. Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state Biochemistry. 35: 11149-11159. PMID 8780519 DOI: 10.1021/bi960858u  0.92
1996 Zvyaga TA, Fahmy K, Siebert F, Sakmar TP. Characterization of the mutant visual pigment responsible for congenital night blindness: a biochemical and Fourier-transform infrared spectroscopy study. Biochemistry. 35: 7536-45. PMID 8652533 DOI: 10.1021/Bi960391N  0.92
1996 Unson CG, Cypess AM, Wu CR, Goldsmith PK, Merrifield RB, Sakmar TP. Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding. Proceedings of the National Academy of Sciences of the United States of America. 93: 310-5. PMID 8552628 DOI: 10.1073/Pnas.93.1.310  0.92
1995 Ernst OP, Hofmann KP, Sakmar TP. Characterization of rhodopsin mutants that bind transducin but fail to induce GTP nucleotide uptake: Classification of mutant pigments by fluorescence, nucleotide release, and flash-induced light-scattering assays Journal of Biological Chemistry. 270: 10580-10586. PMID 7737995  0.92
1995 Fahmy K, Siebert F, Sakmar TP. Photoactivated state of rhodopsin and how it can form. Biophysical Chemistry. 56: 171-81. PMID 7662864 DOI: 10.1016/0301-4622(95)00030-2  0.92
1995 Garcia PD, Onrust R, Bell SM, Sakmar TP, Bourne HR. Transducin-alpha C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells. The Embo Journal. 14: 4460-9. PMID 7556089 DOI: 10.1002/J.1460-2075.1995.Tb00125.X  0.92
1995 Unson CG, Cypess AM, Kim HN, Goldsmith PK, Carruthers CJ, Merrifield RB, Sakmar TP. Characterization of deletion and truncation mutants of the rat glucagon receptor. Seven transmembrane segments are necessary for receptor transport to the plasma membrane and glucagon binding. The Journal of Biological Chemistry. 270: 27720-7. PMID 7499239 DOI: 10.1074/jbc.270.46.27720  0.92
1995 Carruthers CJL, Sakmar TP. [17] Synthesis and expression of synthetic genes: Applications to structure-function studies of receptors Methods in Neurosciences. 25: 322-344. DOI: 10.1016/S1043-9471(05)80047-3  0.92
1994 Zvyaga TA, Fahmy K, Sakmar TP. Characterization of rhodopsin-transducin interaction: a mutant rhodopsin photoproduct with a protonated Schiff base activates transducin. Biochemistry. 33: 9753-61. PMID 8068654 DOI: 10.1021/Bi00198A046  0.92
1994 Carruthers CJL, Unson CG, Hyang Nina Kim, Sakmar TP. Synthesis and expression of a gene for the rat glucagon receptor. Replacement of an aspartic acid in the extracellular domain prevents glucagon binding Journal of Biological Chemistry. 269: 29321-29328. PMID 7961903  0.92
1994 Fahmy K, Siebert F, Sakmar TP. A mutant rhodopsin photoproduct with a protonated Schiff base displays an active-state conformation: a Fourier-transform infrared spectroscopy study. Biochemistry. 33: 13700-5. PMID 7947779 DOI: 10.1021/Bi00250A021  0.92
1994 Arnis S, Fahmy K, Hofmann KP, Sakmar TP. A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin. The Journal of Biological Chemistry. 269: 23879-81. PMID 7929034  0.92
1994 Jäger F, Fahmy K, Sakmar TP, Siebert F. Identification of glutamic acid 113 as the Schiff base proton acceptor in the metarhodopsin II photointermediate of rhodopsin. Biochemistry. 33: 10878-82. PMID 7916209  0.92
1993 Min KC, Zvyaga TA, Cypess AM, Sakmar TP. Characterization of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Mutations on the cytoplasmic surface affect transducin activation Journal of Biological Chemistry. 268: 9400-9404. PMID 8486634  0.92
1993 Zvyaga TA, Min KC, Beck M, Sakmar TP. Movement of the retinylidene Schiff base counterion in rhodopsin by one helix turn reverses the pH dependence of the metarhodopsin I to metarhodopsin II transition Journal of Biological Chemistry. 268: 4661-4667. PMID 8444840  0.92
1993 Fahmy K, Sakmar TP. Light-dependent transducin activation by an ultraviolet-absorbing rhodopsin mutant. Biochemistry. 32: 9165-71. PMID 8396426 DOI: 10.1021/Bi00086A023  0.92
1993 Fahmy K, Sakmar TP. Regulation of the rhodopsin-transducin interaction by a highly conserved carboxylic acid group. Biochemistry. 32: 7229-36. PMID 8343512 DOI: 10.1021/Bi00079A020  0.92
1993 Fahmy K, Jäger F, Beck M, Zvyaga TA, Sakmar TP, Siebert F. Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants. Proceedings of the National Academy of Sciences of the United States of America. 90: 10206-10. PMID 7901852 DOI: 10.1073/pnas.90.21.10206  0.92
1992 Franke RR, Sakmar TP, Graham RM, Khorana HG. Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin. The Journal of Biological Chemistry. 267: 14767-74. PMID 1634520  0.92
1992 Chan T, Lee M, Sakmar TP. Introduction of hydroxyl-bearing amino acids causes bathochromic spectral shifts in rhodopsin: Amino acid substitutions responsible for red-green color pigment spectral tuning Journal of Biological Chemistry. 267: 9478-9480. PMID 1577792  0.92
1992 Lin SW, Sakmar TP, Franke RR, Khorana HG, Mathies RA. Resonance Raman microprobe spectroscopy of rhodopsin mutants: effect of substitutions in the third transmembrane helix. Biochemistry. 31: 5105-11. PMID 1351402 DOI: 10.1021/Bi00137A003  0.92
1991 Sakmar TP, Franke RR, Khorana HG. The role of the retinylidene Schiff base counterion in rhodopsin in determining wavelength absorbance and Schiff base pKa. Proceedings of the National Academy of Sciences of the United States of America. 88: 3079-83. PMID 2014228  0.92
1990 Franke RR, König B, Sakmar TP, Khorana HG, Hofmann KP. Rhodopsin mutants that bind but fail to activate transducin. Science (New York, N.Y.). 250: 123-5. PMID 2218504  0.92
1989 Sakmar TP, Franke RR, Khorana HG. Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin. Proceedings of the National Academy of Sciences of the United States of America. 86: 8309-13. PMID 2573063  0.92
1988 Karnik SS, Sakmar TP, Chen HB, Khorana HG. Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin. Proceedings of the National Academy of Sciences of the United States of America. 85: 8459-63. PMID 3186735  0.92
1988 Sakmar TP, Khorana HG. Total synthesis and expression of a gene for the alpha-subunit of bovine rod outer segment guanine nucleotide-binding protein (transducin). Nucleic Acids Research. 16: 6361-72. PMID 3165194 DOI: 10.1093/Nar/16.14.6361  0.92
1988 Franke RR, Sakmar TP, Oprian DD, Khorana HG. A single amino acid substitution in rhodopsin (lysine 248----leucine) prevents activation of transducin. The Journal of Biological Chemistry. 263: 2119-22. PMID 3123487  0.92
1988 Braiman M, Bubis J, Doi T, Chen HB, Flitsch SL, Franke RR, Gilles-Gonzalez MA, Graham RM, Karnik SS, Khorana HG. Studies on light transduction by bacteriorhodopsin and rhodopsin. Cold Spring Harbor Symposia On Quantitative Biology. 53: 355-64. PMID 3076084 DOI: 10.1101/Sqb.1988.053.01.043  0.92
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