| Year |
Citation |
Score |
| 2024 |
Bedada FB, Thompson BR, Mikkila JL, Chan SS, Choi SH, Toso EA, Kyba M, Metzger JM. Inducing positive inotropy in human iPSC-derived cardiac muscle by gene editing-based activation of the cardiac α-myosin heavy chain. Scientific Reports. 14: 3915. PMID 38365813 DOI: 10.1038/s41598-024-53395-4 |
0.371 |
|
| 2022 |
Martin AA, Thompson BR, Hahn D, Angulski ABB, Hosny N, Cohen H, Metzger JM. Cardiac Sarcomere Signaling in Health and Disease. International Journal of Molecular Sciences. 23. PMID 36555864 DOI: 10.3390/ijms232416223 |
0.317 |
|
| 2022 |
Metzger JM. The road to physiological maturation of stem cell-derived cardiac muscle runs through the sarcomere. Journal of Molecular and Cellular Cardiology. 170: 117-120. PMID 35752207 DOI: 10.1016/j.yjmcc.2022.06.005 |
0.338 |
|
| 2021 |
Law ML, Metzger JM. Cardiac myocyte intrinsic contractility and calcium handling deficits underlie heart organ dysfunction in murine cancer cachexia. Scientific Reports. 11: 23627. PMID 34880268 DOI: 10.1038/s41598-021-02688-z |
0.425 |
|
| 2020 |
Vetter A, Martin AA, Thompson BR, Thomas DD, Metzger JM. Sarcomere integrated biosensor detects myofilament-activating ligands in real time during twitch contractions in live cardiac muscle. Journal of Molecular and Cellular Cardiology. PMID 32791214 DOI: 10.1016/J.Yjmcc.2020.07.012 |
0.498 |
|
| 2020 |
Bez Batti Angulski A, Bauer J, Cohen H, Kobuke K, Campbell KP, Metzger JM. Investigations of an inducible intact dystrophin gene excision system in cardiac and skeletal muscle in vivo. Scientific Reports. 10: 10967. PMID 32620803 DOI: 10.1038/S41598-020-67372-0 |
0.386 |
|
| 2020 |
Wheelwright M, Mikkila J, Bedada FB, Mandegar MA, Thompson BR, Metzger JM. Advancing physiological maturation in human iPSC-derived cardiac muscle by gene editing an inducible adult troponin isoform switch. Stem Cells (Dayton, Ohio). PMID 32497296 DOI: 10.1002/Stem.3235 |
0.517 |
|
| 2020 |
Law ML, Cohen H, Martin AA, Angulski ABB, Metzger JM. Dysregulation of Calcium Handling in Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy: Mechanisms and Experimental Therapeutic Strategies. Journal of Clinical Medicine. 9. PMID 32075145 DOI: 10.3390/Jcm9020520 |
0.406 |
|
| 2020 |
Martin AA, Thompson BR, Metzger JM. Real-Time Investigation of Sarcomere Structure-Function in Live Skeletal Muscle through Fret Biophysical Journal. 118: 278a. DOI: 10.1016/J.Bpj.2019.11.1592 |
0.304 |
|
| 2019 |
Houang EM, Bartos J, Hackel BJ, Lodge TP, Yannopoulos D, Bates FS, Metzger JM. Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury. Jacc. Basic to Translational Science. 4: 275-287. PMID 31061929 DOI: 10.1016/J.Jacbts.2019.01.009 |
0.405 |
|
| 2019 |
Thompson BR, Soller KJ, Vetter A, Yang J, Veglia G, Bowser MT, Metzger JM. Cytoplasmic nucleic acid-based XNAs directly enhance live cardiac cell function by a Ca cycling-independent mechanism via the sarcomere. Journal of Molecular and Cellular Cardiology. PMID 30849419 DOI: 10.1016/J.Yjmcc.2019.02.016 |
0.39 |
|
| 2019 |
Thompson BR, Cohen H, Angulski ABB, Metzger JM. Gene Transfer of Calcium-Binding Proteins into Adult Cardiac Myocytes. Methods in Molecular Biology (Clifton, N.J.). 1929: 187-205. PMID 30710274 DOI: 10.1007/978-1-4939-9030-6_12 |
0.537 |
|
| 2018 |
Maack C, Eschenhagen T, Hamdani N, Heinzel FR, Lyon AR, Manstein DJ, Metzger J, Papp Z, Tocchetti CG, Birhan Yilmaz M, Anker SD, Balligand JL, Bauersachs J, Brutsaert D, Carrier L, et al. Treatments targeting inotropy. European Heart Journal. PMID 30295807 DOI: 10.1093/Eurheartj/Ehy600 |
0.362 |
|
| 2018 |
Law ML, Prins KW, Olander ME, Metzger JM. Exacerbation of dystrophic cardiomyopathy by phospholamban deficiency-mediated chronically increased cardiac Ca cycling in vivo. American Journal of Physiology. Heart and Circulatory Physiology. PMID 30118340 DOI: 10.1152/Ajpheart.00341.2018 |
0.474 |
|
| 2018 |
Vetter AD, Houang EM, Sell JJ, Thompson BR, Sham YY, Metzger JM. TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility. Biophysical Journal. 114: 1646-1656. PMID 29642034 DOI: 10.1016/J.Bpj.2018.02.015 |
0.499 |
|
| 2018 |
Wheelwright M, Win Z, Mikkila JL, Amen KY, Alford PW, Metzger JM. Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy. Plos One. 13: e0194909. PMID 29617427 DOI: 10.1371/Journal.Pone.0194909 |
0.347 |
|
| 2016 |
Bedada FB, Martindale JJ, Arden E, Metzger JM. Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signaling. Scientific Reports. 6: 36803. PMID 27833092 DOI: 10.1038/Srep36803 |
0.375 |
|
| 2016 |
Prins KW, Asp ML, Zhang H, Wang W, Metzger JM. Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice. Jacc. Basic to Translational Science. 1: 122-130. PMID 27482548 DOI: 10.1016/J.Jacbts.2016.02.002 |
0.427 |
|
| 2016 |
Thompson BR, Martindale J, Metzger JM. Sarcomere neutralization in inherited cardiomyopathy: Small molecule proof-of-concept to correct hyper-Ca2+ sensitive myofilaments. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00981.2015. PMID 27199134 DOI: 10.1152/Ajpheart.00981.2015 |
0.508 |
|
| 2016 |
Asp ML, Sjaastad FV, Siddiqui JK, Davis JP, Metzger JM. Effects of Modified Parvalbumin EF-Hand Motifs on Cardiac Myocyte Contractile Function. Biophysical Journal. 110: 2094-105. PMID 27166817 DOI: 10.1016/J.Bpj.2016.03.037 |
0.411 |
|
| 2016 |
Davis J, Davis LC, Correll RN, Makarewich CA, Schwanekamp JA, Moussavi-Harami F, Wang D, York AJ, Wu H, Houser SR, Seidman CE, Seidman JG, Regnier M, Metzger JM, Wu JC, et al. A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy. Cell. PMID 27114035 DOI: 10.1016/J.Cell.2016.04.002 |
0.464 |
|
| 2016 |
Duan D, Rafael-Fortney JA, Blain A, Kass DA, McNally EM, Metzger JM, Spurney CF, Kinnett K. Standard Operating Procedures (SOPs) for Evaluating the Heart in Preclinical Studies of Duchenne Muscular Dystrophy. Journal of Cardiovascular Translational Research. 9: 85-6. PMID 26718928 DOI: 10.1007/S12265-015-9669-6 |
0.406 |
|
| 2015 |
Houang EM, Haman KJ, Filareto A, Perlingeiro RC, Bates FS, Lowe DA, Metzger JM. Membrane-stabilizing copolymers confer marked protection to dystrophic skeletal muscle in vivo. Molecular Therapy. Methods & Clinical Development. 2: 15042. PMID 26623440 DOI: 10.1038/Mtm.2015.42 |
0.327 |
|
| 2015 |
Bedada FB, Wheelwright M, Metzger JM. Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes. Biochimica Et Biophysica Acta. PMID 26578113 DOI: 10.1016/J.Bbamcr.2015.11.005 |
0.47 |
|
| 2015 |
Cui W, Jang A, Zhang P, Thompson B, Townsend D, Metzger JM, Zhang J. Early Detection of Myocardial Bioenergetic Deficits: A 9.4 Tesla Complete Non Invasive 31P MR Spectroscopy Study in Mice with Muscular Dystrophy. Plos One. 10: e0135000. PMID 26262993 DOI: 10.1371/Journal.Pone.0135000 |
0.449 |
|
| 2015 |
Barnabei MS, Sjaastad FV, Townsend D, Bedada FB, Metzger JM. Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A-mediated C-terminal dystrophin cleavage fragment. Science Translational Medicine. 7: 294ra106. PMID 26136477 DOI: 10.1126/Scitranslmed.Aaa4804 |
0.373 |
|
| 2015 |
Heinis FI, Vermillion KL, Andrews MT, Metzger JM. Myocardial performance and adaptive energy pathways in a torpid mammalian hibernator. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 309: R368-77. PMID 26017496 DOI: 10.1152/Ajpregu.00365.2014 |
0.469 |
|
| 2015 |
McNally EM, Kaltman JR, Benson DW, Canter CE, Cripe LH, Duan D, Finder JD, Hoffman EP, Judge DP, Kertesz N, Kinnett K, Kirsch R, Metzger JM, Pearson GD, Rafael-Fortney JA, et al. Contemporary cardiac issues in Duchenne muscular dystrophy. Working Group of the National Heart, Lung, and Blood Institute in collaboration with Parent Project Muscular Dystrophy. Circulation. 131: 1590-8. PMID 25940966 DOI: 10.1161/Circulationaha.114.015151 |
0.438 |
|
| 2015 |
Bartos JA, Matsuura TR, Sarraf M, Youngquist ST, McKnite SH, Rees JN, Sloper DT, Bates FS, Segal N, Debaty G, Lurie KG, Neumar RW, Metzger JM, Riess ML, Yannopoulos D. Bundled postconditioning therapies improve hemodynamics and neurologic recovery after 17 min of untreated cardiac arrest. Resuscitation. 87: 7-13. PMID 25447036 DOI: 10.1016/J.Resuscitation.2014.10.019 |
0.433 |
|
| 2015 |
Wheelwright M, Win Z, Alford PW, Metzger JM. 188. Functional Analysis of Human Induced Pluripotent Stem Cell-Derived Cardiac Myocytes Molecular Therapy. 23: S75. DOI: 10.1016/S1525-0016(16)33793-5 |
0.331 |
|
| 2015 |
Vetter AD, Thompson BR, Houang EH, Sham Y, Metzger JM. Borrowing from the Platypus: Proline Substitution in Cardiac Troponin I Biophysical Journal. 108: 447a. DOI: 10.1016/J.Bpj.2014.11.2439 |
0.339 |
|
| 2015 |
Heinis FI, Metzger JM. Phospholamban-Independent Adrenergic Reserve in SERCA2 Ablated Hearts Biophysical Journal. 108: 362a. DOI: 10.1016/J.Bpj.2014.11.1986 |
0.531 |
|
| 2015 |
Vetter AD, Thompson BR, Metzger JM. Ca2+regulation of the cardiac thin filament Cardiac Cytoarchitecture: How to Maintain a Working Heart. 89-108. DOI: 10.1007/978-3-319-15263-9_5 |
0.364 |
|
| 2014 |
Bedada FB, Chan SS, Metzger SK, Zhang L, Zhang J, Garry DJ, Kamp TJ, Kyba M, Metzger JM. Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes. Stem Cell Reports. 3: 594-605. PMID 25358788 DOI: 10.1016/J.Stemcr.2014.07.012 |
0.439 |
|
| 2014 |
Thompson BR, Metzger JM. Cell biology of sarcomeric protein engineering: disease modeling and therapeutic potential. Anatomical Record (Hoboken, N.J. : 2007). 297: 1663-9. PMID 25125179 DOI: 10.1002/Ar.22966 |
0.469 |
|
| 2014 |
Thompson BR, Houang EM, Sham YY, Metzger JM. Molecular determinants of cardiac myocyte performance as conferred by isoform-specific TnI residues. Biophysical Journal. 106: 2105-14. PMID 24853739 DOI: 10.1016/J.Bpj.2014.04.017 |
0.492 |
|
| 2014 |
Wang W, Asp ML, Guerrero-Serna G, Metzger JM. Differential effects of S100 proteins A2 and A6 on cardiac Ca(2+) cycling and contractile performance. Journal of Molecular and Cellular Cardiology. 72: 117-25. PMID 24631772 DOI: 10.1016/J.Yjmcc.2014.03.003 |
0.527 |
|
| 2014 |
Martindale JJ, Metzger JM. Uncoupling of increased cellular oxidative stress and myocardial ischemia reperfusion injury by directed sarcolemma stabilization. Journal of Molecular and Cellular Cardiology. 67: 26-37. PMID 24362314 DOI: 10.1016/J.Yjmcc.2013.12.008 |
0.364 |
|
| 2014 |
Thompson BR, Martindale J, Metzger JM. Sarcomere Neutralization Therapy in HCM/RCM: Therapeutic Application of the Calcium Desensitizer W7 to Remediate Hyper-Calcium Sensitive Disease States Biophysical Journal. 106: 775a. DOI: 10.1016/J.Bpj.2013.11.4251 |
0.463 |
|
| 2014 |
Houang EM, Haman K, Bates F, Lowe DA, Metzger JM. Membrane-Sealant Copolymers Confer Protection to Dystrophic Skeletal Muscle in Vitro and in Vivo Biophysical Journal. 106: 765a-766a. DOI: 10.1016/J.Bpj.2013.11.4209 |
0.367 |
|
| 2014 |
Heinis FI, Metzger JM. Sarcoplasmic Reticulum-Independent Contractile Function in Serca2 Ablated Hearts Biophysical Journal. 106: 567a. DOI: 10.1016/J.Bpj.2013.11.3145 |
0.509 |
|
| 2014 |
Asp ML, Metzger JM. Contractile Structure-Function of Parvalbumin's Ef-Hand Metal Ion Binding Loop in Isolated Adult Cardiac Myocytes Biophysical Journal. 106: 566a. DOI: 10.1016/J.Bpj.2013.11.3140 |
0.441 |
|
| 2014 |
Vetter AD, Thompson B, Muretta JM, Thomas DD, Metzger JM. Cardiac Troponin I A164H and pH-Dependent Inotropy Biophysical Journal. 106: 349a-350a. DOI: 10.1016/J.Bpj.2013.11.1989 |
0.359 |
|
| 2013 |
Heinis FI, Andersson KB, Christensen G, Metzger JM. Prominent heart organ-level performance deficits in a genetic model of targeted severe and progressive SERCA2 deficiency. Plos One. 8: e79609. PMID 24223976 DOI: 10.1371/Journal.Pone.0079609 |
0.484 |
|
| 2013 |
Asp ML, Martindale JJ, Metzger JM. Direct, differential effects of tamoxifen, 4-hydroxytamoxifen, and raloxifene on cardiac myocyte contractility and calcium handling. Plos One. 8: e78768. PMID 24205315 DOI: 10.1371/Journal.Pone.0078768 |
0.5 |
|
| 2013 |
Wang W, Barnabei MS, Asp ML, Heinis FI, Arden E, Davis J, Braunlin E, Li Q, Davis JP, Potter JD, Metzger JM. Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance. Nature Medicine. 19: 305-12. PMID 23396207 DOI: 10.1038/Nm.3079 |
0.415 |
|
| 2013 |
Asp ML, Martindale JJ, Heinis FI, Wang W, Metzger JM. Calcium mishandling in diastolic dysfunction: mechanisms and potential therapies. Biochimica Et Biophysica Acta. 1833: 895-900. PMID 23022395 DOI: 10.1016/J.Bbamcr.2012.09.007 |
0.468 |
|
| 2013 |
Vetter AD, Thompson BR, Muretta JM, Thomas DD, Metzger JM. Conformational Dynamics of a “Titratable” Cardiac Inotrope Biophysical Journal. 104: 154a. DOI: 10.1016/J.Bpj.2012.11.871 |
0.344 |
|
| 2013 |
Houang EM, Haman K, Bates FS, Metzger JM. Structure-Function of Synthetic Membrane-Sealant Copolymers for Dystrophic Muscle Biophysical Journal. 104: 485a. DOI: 10.1016/J.Bpj.2012.11.2674 |
0.317 |
|
| 2013 |
Asp ML, Martindale JJ, Metzger JM. Mechanism of Acute Tamoxifen and 4-Hydroxytamoxifen-Mediated Contractile Dysfunction in Isolated Adult Cardiac Myocytes Biophysical Journal. 104: 315a. DOI: 10.1016/J.Bpj.2012.11.1746 |
0.49 |
|
| 2013 |
Heinis FI, Andersson KB, Christensen G, Metzger JM. ß-Adrenergic-Mediated Inotropy and Lusitropy in Conditional Cardiac SERCA2 Ablated Mice Biophysical Journal. 104: 17a. DOI: 10.1016/J.Bpj.2012.11.126 |
0.497 |
|
| 2012 |
Davis J, Yasuda S, Palpant NJ, Martindale J, Stevenson T, Converso K, Metzger JM. Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy. Journal of Molecular and Cellular Cardiology. 53: 446-57. PMID 22683325 DOI: 10.1016/J.Yjmcc.2012.05.018 |
0.739 |
|
| 2012 |
Palpant NJ, Houang EM, Sham YY, Metzger JM. pH-responsive titratable inotropic performance of histidine-modified cardiac troponin I. Biophysical Journal. 102: 1570-9. PMID 22500757 DOI: 10.1016/J.Bpj.2012.01.024 |
0.698 |
|
| 2012 |
Barnabei MS, Metzger JM. Ex vivo stretch reveals altered mechanical properties of isolated dystrophin-deficient hearts. Plos One. 7: e32880. PMID 22427904 DOI: 10.1371/Journal.Pone.0032880 |
0.488 |
|
| 2012 |
Heinis FI, Andersson KB, Christensen G, Metzger JM. Conditional SERCA2 Ablation Impairs Systolic and Diastolic Performance of Isolated Perfused Hearts Biophysical Journal. 102: 139a. DOI: 10.1016/J.Bpj.2011.11.768 |
0.503 |
|
| 2012 |
Houang EM, Palpant NJ, Sham YY, Metzger JM. Computational Studies of a pH Responsive Histidine-Modified Cardiac Troponin I Biophysical Journal. 102: 736a. DOI: 10.1016/J.Bpj.2011.11.3993 |
0.699 |
|
| 2012 |
Thompson BR, Houang E, Sham Y, Metzger JM. Molecular Mechanisms of A164H cTnI Biophysical Journal. 102: 560a-561a. DOI: 10.1016/J.Bpj.2011.11.3052 |
0.46 |
|
| 2012 |
Bedada FB, Metzger JM. miR-208A Targeted Suppression of PDE4D Directly Enhances Myocyte Contractile Function via PKA-Mediated Phosphorylation of cTnI and PLN Biophysical Journal. 102: 557a. DOI: 10.1016/J.Bpj.2011.11.3034 |
0.303 |
|
| 2012 |
Asp ML, Martindale JJ, Metzger JM. Tamoxifen has Acute Inhibitory Effects on Contractility in Isolated Adult Rat Cardiac Myocytes Biophysical Journal. 102: 354a-355a. DOI: 10.1016/J.Bpj.2011.11.1939 |
0.468 |
|
| 2011 |
Barnabei MS, Martindale JM, Townsend D, Metzger JM. Exercise and muscular dystrophy: implications and analysis of effects on musculoskeletal and cardiovascular systems. Comprehensive Physiology. 1: 1353-63. PMID 23733645 DOI: 10.1002/Cphy.C100062 |
0.322 |
|
| 2011 |
Rasmussen TL, Kweon J, Diekmann MA, Belema-Bedada F, Song Q, Bowlin K, Shi X, Ferdous A, Li T, Kyba M, Metzger JM, Koyano-Nakagawa N, Garry DJ. ER71 directs mesodermal fate decisions during embryogenesis. Development (Cambridge, England). 138: 4801-12. PMID 21989919 DOI: 10.1242/Dev.070912 |
0.343 |
|
| 2011 |
Townsend D, Daly M, Chamberlain JS, Metzger JM. Age-dependent dystrophin loss and genetic reconstitution establish a molecular link between dystrophin and heart performance during aging. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1821-5. PMID 21730971 DOI: 10.1038/Mt.2011.120 |
0.409 |
|
| 2011 |
Townsend D, Yasuda S, McNally E, Metzger JM. Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3106-14. PMID 21665956 DOI: 10.1096/Fj.10-178913 |
0.462 |
|
| 2011 |
Vandenboom R, Herron T, Favre E, Albayya FP, Metzger JM. Gene transfer, expression, and sarcomeric incorporation of a headless myosin molecule in cardiac myocytes: evidence for a reserve in myofilament motor function. American Journal of Physiology. Heart and Circulatory Physiology. 300: H574-82. PMID 21112946 DOI: 10.1152/Ajpheart.00786.2009 |
0.354 |
|
| 2011 |
Palpant NJ, Bedada FB, Peacock B, Blazar BR, Metzger JM, Tolar J. Cardiac disease in mucopolysaccharidosis type I attributed to catecholaminergic and hemodynamic deficiencies American Journal of Physiology - Heart and Circulatory Physiology. 300: H356-H365. PMID 21076027 DOI: 10.1152/Ajpheart.00774.2010 |
0.737 |
|
| 2010 |
Barnabei MS, Palpant NJ, Metzger JM. Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains. Physiological Genomics. 42: 103-13. PMID 20627938 DOI: 10.1152/Physiolgenomics.00071.2010 |
0.69 |
|
| 2010 |
Palpant NJ, Houang EM, Delport W, Hastings KE, Onufriev AV, Sham YY, Metzger JM. Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations. Physiological Genomics. 42: 287-99. PMID 20423961 DOI: 10.1152/Physiolgenomics.00033.2010 |
0.726 |
|
| 2010 |
Townsend D, Turner I, Yasuda S, Martindale J, Davis J, Shillingford M, Kornegay JN, Metzger JM. Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs. The Journal of Clinical Investigation. 120: 1140-50. PMID 20234088 DOI: 10.1172/Jci41329 |
0.456 |
|
| 2010 |
Davis J, Metzger JM. Combinatorial effects of double cardiomyopathy mutant alleles in rodent myocytes: a predictive cellular model of myofilament dysregulation in disease. Plos One. 5: e9140. PMID 20161772 DOI: 10.1371/Journal.Pone.0009140 |
0.4 |
|
| 2010 |
Palpant NJ, Metzger JM. Aesthetic cardiology: adipose-derived stem cells for myocardial repair. Current Stem Cell Research & Therapy. 5: 145-52. PMID 19941452 DOI: 10.2174/157488810791268654 |
0.677 |
|
| 2010 |
Herron TJ, Devaney E, Mundada L, Arden E, Day S, Guerrero-Serna G, Turner I, Westfall M, Metzger JM. Ca2+-independent positive molecular inotropy for failing rabbit and human cardiac muscle by alpha-myosin motor gene transfer. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 415-24. PMID 19801488 DOI: 10.1096/Fj.09-140566 |
0.475 |
|
| 2009 |
Wang W, Martindale J, Metzger JM. Parvalbumin: Targeting calcium handling in cardiac diastolic dysfunction. General Physiology and Biophysics. 28: F3-6. PMID 20093724 |
0.415 |
|
| 2009 |
Townsend D, Yasuda S, Chamberlain J, Metzger JM. Cardiac consequences to skeletal muscle-centric therapeutics for Duchenne muscular dystrophy. Trends in Cardiovascular Medicine. 19: 50-55. PMID 19577712 DOI: 10.1016/J.Tcm.2009.04.006 |
0.424 |
|
| 2009 |
Palpant NJ, Szatkowski ML, Wang W, Townsend D, Bedada FB, Koch LG, Britton SL, Metzger JM. Artificial selection for whole animal low intrinsic aerobic capacity co-segregates with hypoxia-induced cardiac pump failure. Plos One. 4: e6117. PMID 19568432 DOI: 10.1371/Journal.Pone.0006117 |
0.734 |
|
| 2009 |
Palpant NJ, D'Alecy LG, Metzger JM. Single histidine button in cardiac troponin I sustains heart performance in response to severe hypercapnic respiratory acidosis in vivo. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 1529-40. PMID 19141534 DOI: 10.1096/Fj.08-121996 |
0.717 |
|
| 2009 |
Herron TJ, Devaney EJ, Mundada L, Day S, Guerrero-Serna G, Turner I, Arden E, Westfall M, Metzger J. Calcium Independent Positive Inotropy By Fast Cardiac Myosin Motor Gene Transfer In Slow Myosin Dominant Ventricular Myocytes Biophysical Journal. 96: 223a. DOI: 10.1016/J.Bpj.2008.12.1935 |
0.435 |
|
| 2008 |
Russell MW, Townsend D, Metzger JM. Cardiac involvement in the dystrophinopathies. Journal of Pediatric Rehabilitation Medicine. 1: 211-23. PMID 21791770 |
0.356 |
|
| 2008 |
Turner I, Belema-Bedada F, Martindale J, Townsend D, Wang W, Palpant N, Yasuda SC, Barnabei M, Fomicheva E, Metzger JM. Molecular cardiology in translation: gene, cell and chemical-based experimental therapeutics for the failing heart. Journal of Cardiovascular Translational Research. 1: 317-27. PMID 19956787 DOI: 10.1007/S12265-008-9065-6 |
0.7 |
|
| 2008 |
Davis J, Westfall MV, Townsend D, Blankinship M, Herron TJ, Guerrero-Serna G, Wang W, Devaney E, Metzger JM. Designing heart performance by gene transfer. Physiological Reviews. 88: 1567-651. PMID 18923190 DOI: 10.1152/Physrev.00039.2007 |
0.473 |
|
| 2008 |
Palpant NJ, Day SM, Herron TJ, Converso KL, Metzger JM. Single histidine-substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction. Cardiovascular Research. 80: 209-18. PMID 18635554 DOI: 10.1093/Cvr/Cvn198 |
0.714 |
|
| 2008 |
Fomicheva EV, Turner II, Edwards TG, Hoff J, Arden E, D'Alecy LG, Metzger JM. Double oxygen-sensing vector system for robust hypoxia/ischemia-regulated gene induction in cardiac muscle in vitro and in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1594-601. PMID 18578010 DOI: 10.1038/Mt.2008.136 |
0.405 |
|
| 2008 |
Ng R, Metzger JM, Claflin DR, Faulkner JA. Poloxamer 188 reduces the contraction-induced force decline in lumbrical muscles from mdx mice. American Journal of Physiology. Cell Physiology. 295: C146-50. PMID 18495816 DOI: 10.1152/Ajpcell.00017.2008 |
0.367 |
|
| 2008 |
Wang W, Metzger JM. Parvalbumin isoforms for enhancing cardiac diastolic function. Cell Biochemistry and Biophysics. 51: 1-8. PMID 18458829 DOI: 10.1007/S12013-008-9011-X |
0.526 |
|
| 2008 |
Davis J, Wen H, Edwards T, Metzger JM. Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants. Journal of Molecular and Cellular Cardiology. 44: 891-904. PMID 18423659 DOI: 10.1016/J.Yjmcc.2008.02.274 |
0.485 |
|
| 2008 |
Townsend D, Yasuda S, Li S, Chamberlain JS, Metzger JM. Emergent dilated cardiomyopathy caused by targeted repair of dystrophic skeletal muscle. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 832-5. PMID 18414480 DOI: 10.1038/Mt.2008.52 |
0.445 |
|
| 2008 |
Herron TJ, Devaney EJ, Metzger JM. Modulation of cardiac performance by motor protein gene transfer. Annals of the New York Academy of Sciences. 1123: 96-104. PMID 18375581 DOI: 10.1196/Annals.1420.011 |
0.488 |
|
| 2008 |
Day SM, Coutu P, Wang W, Herron T, Turner I, Shillingford M, Lacross NC, Converso KL, Piao L, Li J, Lopatin AN, Metzger JM. Cardiac-directed parvalbumin transgene expression in mice shows marked heart rate dependence of delayed Ca2+ buffering action. Physiological Genomics. 33: 312-22. PMID 18334547 DOI: 10.1152/Physiolgenomics.00302.2007 |
0.801 |
|
| 2007 |
Palpant NJ, Yasuda S, MacDougald O, Metzger JM. Non-canonical Wnt signaling enhances differentiation of Sca1+/c-kit+ adipose-derived murine stromal vascular cells into spontaneously beating cardiac myocytes. Journal of Molecular and Cellular Cardiology. 43: 362-70. PMID 17706246 DOI: 10.1016/J.Yjmcc.2007.06.012 |
0.706 |
|
| 2007 |
Yasuda S, Coutu P, Sadayappan S, Robbins J, Metzger JM. Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes. Circulation Research. 101: 377-86. PMID 17615373 DOI: 10.1161/Circresaha.106.145557 |
0.798 |
|
| 2007 |
Westfall MV, Metzger JM. Single amino acid substitutions define isoform-specific effects of troponin I on myofilament Ca2+ and pH sensitivity. Journal of Molecular and Cellular Cardiology. 43: 107-18. PMID 17602701 DOI: 10.1016/J.Yjmcc.2007.05.017 |
0.444 |
|
| 2007 |
Rodenbaugh DW, Wang W, Davis J, Edwards T, Potter JD, Metzger JM. Parvalbumin isoforms differentially accelerate cardiac myocyte relaxation kinetics in an animal model of diastolic dysfunction. American Journal of Physiology. Heart and Circulatory Physiology. 293: H1705-13. PMID 17545482 DOI: 10.1152/Ajpheart.00232.2007 |
0.39 |
|
| 2007 |
Davis J, Wen H, Edwards T, Metzger JM. Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling. Circulation Research. 100: 1494-502. PMID 17463320 DOI: 10.1161/01.Res.0000268412.34364.50 |
0.462 |
|
| 2007 |
Townsend D, Blankinship MJ, Allen JM, Gregorevic P, Chamberlain JS, Metzger JM. Systemic administration of micro-dystrophin restores cardiac geometry and prevents dobutamine-induced cardiac pump failure. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1086-92. PMID 17440445 DOI: 10.1038/Sj.Mt.6300144 |
0.505 |
|
| 2007 |
Day SM, Westfall MV, Metzger JM. Tuning cardiac performance in ischemic heart disease and failure by modulating myofilament function. Journal of Molecular Medicine (Berlin, Germany). 85: 911-21. PMID 17396243 DOI: 10.1007/S00109-007-0181-6 |
0.515 |
|
| 2007 |
Herron TJ, Vandenboom R, Fomicheva E, Mundada L, Edwards T, Metzger JM. Calcium-independent negative inotropy by beta-myosin heavy chain gene transfer in cardiac myocytes. Circulation Research. 100: 1182-90. PMID 17363698 DOI: 10.1161/01.Res.0000264102.00706.4E |
0.426 |
|
| 2007 |
Chamberlain JS, Metzger J, Reyes M, Townsend D, Faulkner JA. Dystrophin-deficient mdx mice display a reduced life span and are susceptible to spontaneous rhabdomyosarcoma. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2195-204. PMID 17360850 DOI: 10.1096/Fj.06-7353Com |
0.307 |
|
| 2007 |
Ocorr K, Reeves NL, Wessells RJ, Fink M, Chen HS, Akasaka T, Yasuda S, Metzger JM, Giles W, Posakony JW, Bodmer R. KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. Proceedings of the National Academy of Sciences of the United States of America. 104: 3943-8. PMID 17360457 DOI: 10.1073/Pnas.0609278104 |
0.429 |
|
| 2007 |
Townsend D, Yasuda S, Metzger J. Cardiomyopathy of Duchenne muscular dystrophy: pathogenesis and prospect of membrane sealants as a new therapeutic approach. Expert Review of Cardiovascular Therapy. 5: 99-109. PMID 17187461 DOI: 10.1586/14779072.5.1.99 |
0.413 |
|
| 2006 |
Day S, Davis J, Westfall M, Metzger J. Genetic engineering and therapy for inherited and acquired cardiomyopathies. Annals of the New York Academy of Sciences. 1080: 437-50. PMID 17132800 DOI: 10.1196/Annals.1380.033 |
0.495 |
|
| 2006 |
Day SM, Westfall MV, Fomicheva EV, Hoyer K, Yasuda S, La Cross NC, D'Alecy LG, Ingwall JS, Metzger JM. Histidine button engineered into cardiac troponin I protects the ischemic and failing heart. Nature Medicine. 12: 181-9. PMID 16429145 DOI: 10.1038/Nm1346 |
0.5 |
|
| 2005 |
Yasuda S, Townsend D, Michele DE, Favre EG, Day SM, Metzger JM. Dystrophic heart failure blocked by membrane sealant poloxamer. Nature. 436: 1025-9. PMID 16025101 DOI: 10.1038/Nature03844 |
0.504 |
|
| 2005 |
Coutu P, Metzger JM. Genetic manipulation of calcium-handling proteins in cardiac myocytes. I. Experimental studies. American Journal of Physiology. Heart and Circulatory Physiology. 288: H601-12. PMID 15331372 DOI: 10.1152/Ajpheart.00424.2004 |
0.811 |
|
| 2005 |
Coutu P, Metzger JM. Genetic manipulation of calcium-handling proteins in cardiac myocytes. II. Mathematical modeling studies. American Journal of Physiology. Heart and Circulatory Physiology. 288: H613-31. PMID 15331371 DOI: 10.1152/Ajpheart.00425.2004 |
0.803 |
|
| 2004 |
Michele DE, Szatkowski ML, Albayya FP, Metzger JM. Parvalbumin gene delivery improves diastolic function in the aged myocardium in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 399-403. PMID 15294186 DOI: 10.1016/J.Ymthe.2004.05.011 |
0.425 |
|
| 2004 |
Hirsch JC, Borton AR, Albayya FP, Russell MW, Ohye RG, Metzger JM. Comparative analysis of parvalbumin and SERCA2a cardiac myocyte gene transfer in a large animal model of diastolic dysfunction. American Journal of Physiology. Heart and Circulatory Physiology. 286: H2314-21. PMID 15148059 DOI: 10.1152/Ajpheart.01137.2003 |
0.538 |
|
| 2004 |
Coutu P, Bennett CN, Favre EG, Day SM, Metzger JM. Parvalbumin corrects slowed relaxation in adult cardiac myocytes expressing hypertrophic cardiomyopathy-linked alpha-tropomyosin mutations. Circulation Research. 94: 1235-41. PMID 15059934 DOI: 10.1161/01.Res.0000126923.46786.Fd |
0.774 |
|
| 2004 |
Metzger JM, Westfall MV. Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation. Circulation Research. 94: 146-58. PMID 14764650 DOI: 10.1161/01.Res.0000110083.17024.60 |
0.463 |
|
| 2003 |
Westfall MV, Metzger JM. Gene transfer of troponin I isoforms, mutants, and chimeras. Advances in Experimental Medicine and Biology. 538: 169-74; discussion 1. PMID 15098664 DOI: 10.1007/978-1-4419-9029-7_15 |
0.502 |
|
| 2003 |
Hirsch JC, Borton AR, Metzger JM. Isolation, culture, and gene transfer of adult canine cardiac myocytes. Methods in Molecular Biology (Clifton, N.J.). 219: 145-57. PMID 12597005 DOI: 10.1385/1-59259-350-X:145 |
0.391 |
|
| 2003 |
Coutu P, Hirsch JC, Szatkowski ML, Metzger JM. Targeting diastolic dysfunction by genetic engineering of calcium handling proteins. Trends in Cardiovascular Medicine. 13: 63-7. PMID 12586441 DOI: 10.1016/S1050-1738(02)00213-X |
0.789 |
|
| 2003 |
Metzger JM, Michele DE, Rust EM, Borton AR, Westfall MV. Sarcomere thin filament regulatory isoforms. Evidence of a dominant effect of slow skeletal troponin I on cardiac contraction. The Journal of Biological Chemistry. 278: 13118-23. PMID 12551900 DOI: 10.1074/Jbc.M212601200 |
0.507 |
|
| 2002 |
Vandenboom R, Metzger JM. A "wringing" endorsement for myosin phosphorylation in the heart. Molecular Interventions. 2: 422-4. PMID 14993403 DOI: 10.1124/Mi.2.7.422 |
0.409 |
|
| 2002 |
Metzger JM. HDAC lightens a heavy heart. Nature Medicine. 8: 1078-9. PMID 12357239 DOI: 10.1038/Nm1002-1078 |
0.407 |
|
| 2002 |
Westfall MV, Borton AR, Albayya FP, Metzger JM. Myofilament calcium sensitivity and cardiac disease: insights from troponin I isoforms and mutants. Circulation Research. 91: 525-31. PMID 12242271 DOI: 10.1161/01.Res.0000034710.46739.C0 |
0.501 |
|
| 2002 |
Michele DE, Gomez CA, Hong KE, Westfall MV, Metzger JM. Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade. Circulation Research. 91: 255-62. PMID 12169652 DOI: 10.1161/01.Res.0000027530.58419.82 |
0.514 |
|
| 2002 |
Michele DE, Coutu P, Metzger JM. Divergent abnormal muscle relaxation by hypertrophic cardiomyopathy and nemaline myopathy mutant tropomyosins. Physiological Genomics. 9: 103-11. PMID 12006676 DOI: 10.1152/Physiolgenomics.00099.2001 |
0.78 |
|
| 2002 |
Coutu P, Metzger JM. Optimal range for parvalbumin as relaxing agent in adult cardiac myocytes: gene transfer and mathematical modeling. Biophysical Journal. 82: 2565-79. PMID 11964244 DOI: 10.1016/S0006-3495(02)75599-9 |
0.781 |
|
| 2001 |
Westfall MV, Metzger JM. Troponin I isoforms and chimeras: tuning the molecular switch of cardiac contraction. News in Physiological Sciences : An International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. 16: 278-81. PMID 11719605 DOI: 10.1152/Physiologyonline.2001.16.6.278 |
0.508 |
|
| 2001 |
Lu Z, Swartz DR, Metzger JM, Moss RL, Walker JW. Regulation of force development studied by photolysis of caged ADP in rabbit skinned psoas fibers Biophysical Journal. 81: 334-344. PMID 11423418 DOI: 10.1016/S0006-3495(01)75703-7 |
0.363 |
|
| 2001 |
Westfall MV, Turner I, Albayya FP, Metzger JM. Troponin I chimera analysis of the cardiac myofilament tension response to protein kinase A. American Journal of Physiology. Cell Physiology. 280: C324-32. PMID 11208528 DOI: 10.1152/Ajpcell.2001.280.2.C324 |
0.416 |
|
| 2001 |
Szatkowski ML, Westfall MV, Gomez CA, Wahr PA, Michele DE, DelloRusso C, Turner II, Hong KE, Albayya FP, Metzger JM. In vivo acceleration of heart relaxation performance by parvalbumin gene delivery. The Journal of Clinical Investigation. 107: 191-8. PMID 11160135 DOI: 10.1172/Jci9862 |
0.502 |
|
| 2000 |
Michele DE, Metzger JM. Contractile dysfunction in hypertrophic cardiomyopathy: elucidating primary defects of mutant contractile proteins by gene transfer. Trends in Cardiovascular Medicine. 10: 177-82. PMID 11239799 DOI: 10.1016/S1050-1738(00)00067-0 |
0.492 |
|
| 2000 |
Michele DE, Metzger JM. Physiological consequences of tropomyosin mutations associated with cardiac and skeletal myopathies. Journal of Molecular Medicine (Berlin, Germany). 78: 543-53. PMID 11199327 DOI: 10.1007/S001090000161 |
0.432 |
|
| 2000 |
Wahr PA, Michele DE, Metzger JM. Effects of aging on single cardiac myocyte function in Fischer 344 x Brown Norway rats. American Journal of Physiology. Heart and Circulatory Physiology. 279: H559-65. PMID 10924054 DOI: 10.1152/Ajpheart.2000.279.2.H559 |
0.366 |
|
| 2000 |
Westfall MV, Albayya FP, Turner II, Metzger JM. Chimera analysis of troponin I domains that influence Ca(2+)-activated myofilament tension in adult cardiac myocytes. Circulation Research. 86: 470-7. PMID 10700453 DOI: 10.1161/01.Res.86.4.470 |
0.463 |
|
| 1999 |
Michele DE, Albayya FP, Metzger JM. A nemaline myopathy mutation in alpha-tropomyosin causes defective regulation of striated muscle force production. The Journal of Clinical Investigation. 104: 1575-81. PMID 10587521 DOI: 10.1172/Jci7842 |
0.384 |
|
| 1999 |
Michele DE, Albayya FP, Metzger JM. Direct, convergent hypersensitivity of calcium-activated force generation produced by hypertrophic cardiomyopathy mutant alpha-tropomyosins in adult cardiac myocytes. Nature Medicine. 5: 1413-7. PMID 10581085 DOI: 10.1038/70990 |
0.451 |
|
| 1999 |
Wahr PA, Michele DE, Metzger JM. Parvalbumin gene transfer corrects diastolic dysfunction in diseased cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 96: 11982-5. PMID 10518562 DOI: 10.1073/Pnas.96.21.11982 |
0.532 |
|
| 1999 |
Westfall MV, Albayya FP, Metzger JM. Functional analysis of troponin I regulatory domains in the intact myofilament of adult single cardiac myocytes. The Journal of Biological Chemistry. 274: 22508-16. PMID 10428827 DOI: 10.1074/Jbc.274.32.22508 |
0.504 |
|
| 1999 |
Michele DE, Albayya FP, Metzger JM. Thin filament protein dynamics in fully differentiated adult cardiac myocytes: toward a model of sarcomere maintenance. The Journal of Cell Biology. 145: 1483-95. PMID 10385527 DOI: 10.1083/Jcb.145.7.1483 |
0.41 |
|
| 1999 |
Metzger JM, Wahr PA, Michele DE, Albayya F, Westfall MV. Effects of myosin heavy chain isoform switching on Ca2+-activated tension development in single adult cardiac myocytes. Circulation Research. 84: 1310-7. PMID 10364569 DOI: 10.1161/01.Res.84.11.1310 |
0.51 |
|
| 1999 |
Rust EM, Albayya FP, Metzger JM. Identification of a contractile deficit in adult cardiac myocytes expressing hypertrophic cardiomyopathy-associated mutant troponin T proteins. The Journal of Clinical Investigation. 103: 1459-67. PMID 10330428 DOI: 10.1172/Jci6377 |
0.482 |
|
| 1999 |
Wahr PA, Metzger JM. Role of Ca2+ and cross-bridges in skeletal muscle thin filament activation probed with Ca2+ sensitizers. Biophysical Journal. 76: 2166-76. PMID 10096910 DOI: 10.1016/S0006-3495(99)77371-6 |
0.349 |
|
| 1998 |
Wahr PA, Metzger JM. Peak power output is maintained in rabbit psoas and rat soleus single muscle fibers when CTP replaces ATP. Journal of Applied Physiology (Bethesda, Md. : 1985). 85: 76-83. PMID 9655758 DOI: 10.1152/Jappl.1998.85.1.76 |
0.326 |
|
| 1998 |
Rust EM, Westfall MV, Metzger JM. Stability of the contractile assembly and Ca2+-activated tension in adenovirus infected adult cardiac myocytes. Molecular and Cellular Biochemistry. 181: 143-55. PMID 9562251 DOI: 10.1023/A:1006802719136 |
0.402 |
|
| 1997 |
Metzger JM, Samuelson LC, Rust EM, Westfall MV. Embryonic stem cell cardiogenesis applications for cardiovascular research. Trends in Cardiovascular Medicine. 7: 63-8. PMID 21235866 DOI: 10.1016/S1050-1738(96)00138-7 |
0.424 |
|
| 1997 |
Acakpo-Satchivi LJ, Edelmann W, Sartorius C, Lu BD, Wahr PA, Watkins SC, Metzger JM, Leinwand L, Kucherlapati R. Growth and muscle defects in mice lacking adult myosin heavy chain genes. The Journal of Cell Biology. 139: 1219-29. PMID 9382868 DOI: 10.1083/Jcb.139.5.1219 |
0.354 |
|
| 1997 |
Rust EM, Westfall MV, Samuelson LC, Metzger JM. Gene transfer into mouse embryonic stem cell-derived cardiac myocytes mediated by recombinant adenovirus. In Vitro Cellular & Developmental Biology. Animal. 33: 270-6. PMID 9156342 DOI: 10.1007/S11626-997-0046-X |
0.42 |
|
| 1997 |
Westfall MV, Rust EM, Metzger JM. Slow skeletal troponin I gene transfer, expression, and myofilament incorporation enhances adult cardiac myocyte contractile function. Proceedings of the National Academy of Sciences of the United States of America. 94: 5444-9. PMID 9144257 DOI: 10.1073/Pnas.94.10.5444 |
0.535 |
|
| 1997 |
Westfall MV, Pasyk KA, Yule DI, Samuelson LC, Metzger JM. Ultrastructure and cell-cell coupling of cardiac myocytes differentiating in embryonic stem cell cultures. Cell Motility and the Cytoskeleton. 36: 43-54. PMID 8986376 DOI: 10.1002/(Sici)1097-0169(1997)36:1<43::Aid-Cm4>3.0.Co;2-I |
0.435 |
|
| 1997 |
Metzger JM. Effects of troponin C isoforms on pH sensitivity of contraction in mammalian fast and slow skeletal muscle fibres. The Journal of Physiology. 163-72. PMID 8730592 DOI: 10.1113/Jphysiol.1996.Sp021298 |
0.325 |
|
| 1997 |
Westfall MV, Rust EM, Albayya F, Metzger JM. Adenovirus-mediated myofilament gene transfer into adult cardiac myocytes. Methods in Cell Biology. 52: 307-322. DOI: 10.1016/S0091-679X(08)60385-4 |
0.432 |
|
| 1996 |
Westfall MV, Samuelson LC, Metzger JM. Troponin I isoform expression is developmentally regulated in differentiating embryonic stem cell-derived cardiac myocytes. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 206: 24-38. PMID 9019244 DOI: 10.1002/(Sici)1097-0177(199605)206:1<24::Aid-Aja3>3.0.Co;2-2 |
0.469 |
|
| 1996 |
Metzger JM. pH dependence of myosin binding-induced activation of the thin filament in cardiac myocytes and skeletal fibers. The American Journal of Physiology. 270: H1008-14. PMID 8780197 DOI: 10.1152/Ajpheart.1996.270.3.H1008 |
0.438 |
|
| 1996 |
Metzger JM. Effects of phosphate and ADP on shortening velocity during maximal and submaximal calcium activation of the thin filament in skeletal muscle fibers. Biophysical Journal. 70: 409-17. PMID 8770217 DOI: 10.1016/S0006-3495(96)79584-X |
0.322 |
|
| 1996 |
Metzger JM, Lin WI, Samuelson LC. Vital staining of cardiac myocytes during embryonic stem cell cardiogenesis in vitro. Circulation Research. 78: 547-52. PMID 8635211 DOI: 10.1161/01.Res.78.4.547 |
0.454 |
|
| 1996 |
Metzger JM. Effects on Ca(2+)-activated tension due to a synthetic NH2-terminal actin peptide in single skeletal muscle fibers. The American Journal of Physiology. 269: C1193-9. PMID 7491909 DOI: 10.1152/Ajpcell.1995.269.5.C1193 |
0.323 |
|
| 1995 |
Metzger JM. Myosin binding-induced cooperative activation of the thin filament in cardiac myocytes and skeletal muscle fibers. Biophysical Journal. 68: 1430-42. PMID 7787029 DOI: 10.1016/S0006-3495(95)80316-4 |
0.453 |
|
| 1995 |
Metzger JM, Lin WI, Johnston RA, Westfall MV, Samuelson LC. Myosin heavy chain expression in contracting myocytes isolated during embryonic stem cell cardiogenesis. Circulation Research. 76: 710-9. PMID 7728987 DOI: 10.1161/01.Res.76.5.710 |
0.431 |
|
| 1995 |
Metzger JM, Rudnicki MA, Westfall MV. Altered Ca2+ sensitivity of tension in single skeletal muscle fibres from MyoD gene-inactivated mice. The Journal of Physiology. 485: 447-53. PMID 7666367 DOI: 10.1113/Jphysiol.1995.Sp020741 |
0.406 |
|
| 1994 |
Metzger JM, Lin WI, Samuelson LC. Transition in cardiac contractile sensitivity to calcium during the in vitro differentiation of mouse embryonic stem cells. The Journal of Cell Biology. 126: 701-11. PMID 8045934 DOI: 10.1083/Jcb.126.3.701 |
0.512 |
|
| 1993 |
Metzger JM, Parmacek MS, Barr E, Pasyk K, Lin WI, Cochrane KL, Field LJ, Leiden JM. Skeletal troponin C reduces contractile sensitivity to acidosis in cardiac myocytes from transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 90: 9036-40. PMID 8415650 DOI: 10.1073/Pnas.90.19.9036 |
0.521 |
|
| 1992 |
Metzger JM, Moss RL. Myosin light chain 2 modulates calcium-sensitive cross-bridge transitions in vertebrate skeletal muscle. Biophysical Journal. 63: 460-8. PMID 1420891 DOI: 10.1016/S0006-3495(92)81614-4 |
0.371 |
|
| 1991 |
Metzger JM, Moss RL. Kinetics of a Ca(2+)-sensitive cross-bridge state transition in skeletal muscle fibers. Effects due to variations in thin filament activation by extraction of troponin C. The Journal of General Physiology. 98: 233-48. PMID 1940850 DOI: 10.1085/Jgp.98.2.233 |
0.359 |
|
| 1990 |
Hofmann PA, Metzger JM, Greaser ML, Moss RL. Effects of partial extraction of light chain 2 on the Ca2+ sensitivities of isometric tension, stiffness, and velocity of shortening in skinned skeletal muscle fibers. The Journal of General Physiology. 95: 477-98. PMID 2324702 DOI: 10.1085/Jgp.95.3.477 |
0.325 |
|
| 1990 |
Metzger JM, Moss RL. Calcium-sensitive cross-bridge transitions in mammalian fast and slow skeletal muscle fibers. Science (New York, N.Y.). 247: 1088-90. PMID 2309121 DOI: 10.1126/Science.2309121 |
0.327 |
|
| 1990 |
Metzger JM, Moss RL. pH modulation of the kinetics of a Ca2(+)-sensitive cross-bridge state transition in mammalian single skeletal muscle fibres. The Journal of Physiology. 428: 751-64. PMID 2231432 DOI: 10.1113/Jphysiol.1990.Sp018239 |
0.331 |
|
| 1990 |
Metzger JM, Moss RL. Effects of tension and stiffness due to reduced pH in mammalian fast- and slow-twitch skinned skeletal muscle fibres. The Journal of Physiology. 428: 737-50. PMID 2231431 DOI: 10.1113/Jphysiol.1990.Sp018238 |
0.321 |
|
| 1989 |
Metzger JM, Moss RL. Depression of Ca2+ insensitive tension due to reduced pH in partially troponin-extracted skinned skeletal muscle fibers. Biophysical Journal. 54: 1169-73. PMID 3233271 DOI: 10.1016/S0006-3495(88)83052-2 |
0.317 |
|
| 1989 |
Metzger JM, Greaser ML, Moss RL. Variations in cross-bridge attachment rate and tension with phosphorylation of myosin in mammalian skinned skeletal muscle fibers. Implications for twitch potentiation in intact muscle. The Journal of General Physiology. 93: 855-83. PMID 2661721 DOI: 10.1085/Jgp.93.5.855 |
0.342 |
|
| 1988 |
Metzger JM, Moss RL. Greater hydrogen ion-induced depression of tension and velocity in skinned single fibres of rat fast than slow muscles. The Journal of Physiology. 393: 727-42. PMID 3446809 DOI: 10.1113/Jphysiol.1987.Sp016850 |
0.301 |
|
| 1988 |
Metzger JM, Moss RL. Thin filament regulation of shortening velocity in rat skinned skeletal muscle: effects of osmotic compression. The Journal of Physiology. 398: 165-75. PMID 2455798 DOI: 10.1113/Jphysiol.1988.Sp017036 |
0.321 |
|
| 1986 |
Fitts RH, Metzger JM, Riley DA, Unsworth BR. Models of disuse: a comparison of hindlimb suspension and immobilization. Journal of Applied Physiology (Bethesda, Md. : 1985). 60: 1946-53. PMID 3722061 DOI: 10.1152/Jappl.1986.60.6.1946 |
0.356 |
|
| 1985 |
Metzger JM, Scheidt KB, Fitts RH. Histochemical and physiological characteristics of the rat diaphragm. Journal of Applied Physiology (Bethesda, Md. : 1985). 58: 1085-91. PMID 3988665 DOI: 10.1152/Jappl.1985.58.4.1085 |
0.303 |
|
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