Dennis L. Wright - Publications

Affiliations: 
University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Organic Chemistry, Physical Chemistry

112 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Medved J, Wood WM, van Heyst MD, Sherafat A, Song JY, Sakya S, Wright DL, Nishiyama A. Novel guanidine compounds inhibit platelet-derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation. Glia. PMID 33098183 DOI: 10.1002/glia.23930  0.12
2020 Dvořák Z, Kopp F, Costello CM, Kemp JS, Li H, Vrzalová A, Štěpánková M, Bartoňková I, Jiskrová E, Poulíková K, Vyhlídalová B, Nordstroem LU, Karunaratne CV, Ranhotra HS, Mun KS, ... Wright D, et al. Targeting the pregnane X receptor using microbial metabolite mimicry. Embo Molecular Medicine. e11621. PMID 32153125 DOI: 10.15252/Emmm.201911621  0.01
2019 Krucinska J, Lombardo MN, Erlandsen H, Hazeen A, Duay SS, Pattis JG, Robinson VL, May ER, Wright DL. Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate. Scientific Reports. 9: 17106. PMID 31745118 DOI: 10.1038/S41598-019-53301-3  0.68
2019 Reeve SM, Si D, Krucinska J, Yan Y, Viswanathan K, Wang S, Holt GT, Frenkel MS, Ojewole A, Estrada A, Agabiti SS, Alverson JB, Gibson ND, Priestly ND, Wiemer AJ, ... ... Wright DL, et al. Toward Broad Spectrum DHFR inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus. Acs Infectious Diseases. PMID 31565920 DOI: 10.1021/Acsinfecdis.9B00222  0.68
2019 Lombardo MN, G-Dayanandan N, Keshipeddy S, Zhou W, Si D, Reeve SM, Alverson J, Barney P, Walker L, Hoody J, Priestley N, Obach RS, Wright DL. Structure guided in-vitro to in-vivo pharmacokinetic optimization of propargyl-linked antifolates. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31201212 DOI: 10.1124/Dmd.119.086504  0.68
2019 Hajian B, Scocchera E, Shoen C, Krucinska J, Viswanathan K, G-Dayanandan N, Erlandsen H, Estrada A, Mikušová K, Korduláková J, Cynamon M, Wright D. Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents. Cell Chemical Biology. PMID 30930162 DOI: 10.1016/J.Chembiol.2019.02.013  0.68
2019 Krucinska J, Falcone E, Erlandsen H, Hazeen A, Lombardo MN, Estrada A, Robinson VL, Anderson A, Wright DL. Structural and Functional Studies of Bacterial Enolase, a Potential Target Against Gram-Negative Pathogens. Biochemistry. PMID 30714720 DOI: 10.1021/Acs.Biochem.8B01298  0.68
2019 Cannone Z, Shaqra A, Lorenc C, Henowitz L, Keshipeddy S, Robinson VL, Zweifach A, Wright DL, Peczuh M. Post Glycosylation Diversification (PGD): An Approach for Assembling Collections of Glycosylated Small Molecules. Acs Combinatorial Science. PMID 30607941 DOI: 10.1021/Acscombsci.8B00139  0.68
2018 Haney SL, Varney ML, Safranek HR, Chhonker YS, G-Dayanandan N, Talmon G, Murry DJ, Wiemer AJ, Wright DL, Holstein SA. Tropolone-induced effects on the unfolded protein response pathway and apoptosis in multiple myeloma cells are dependent on iron. Leukemia Research. 77: 17-27. PMID 30612055 DOI: 10.1016/J.Leukres.2018.12.007  0.68
2018 Bond MJ, Bleiler M, Harrison LE, Scocchera EW, Nakanishi M, G-Dayanandan N, Keshipeddy S, Rosenberg DW, Wright DL, Giardina C. Spindle assembly disruption and cancer cell apoptosis with a CLTC-binding compound. Molecular Cancer Research : McR. PMID 29769406 DOI: 10.1158/1541-7786.Mcr-18-0178  0.68
2017 Cammarata M, Thyer R, Lombardo M, Anderson A, Wright D, Ellington A, Brodbelt JS. Characterization of trimethoprim resistant dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates. Chemical Science. 8: 4062-4072. PMID 29967675 DOI: 10.1039/C6Sc05235E  0.04
2017 Haney SL, Allen C, Varney ML, Dykstra KM, Falcone ER, Colligan SH, Hu Q, Aldridge AM, Wright DL, Wiemer AJ, Holstein SA. Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells. Oncotarget. 8: 76085-76098. PMID 29100294 DOI: 10.18632/Oncotarget.18543  0.16
2017 Pozhidaeva A, Valles G, Wang F, Wu J, Sterner DE, Nguyen P, Weinstock J, Kumar KGS, Kanyo J, Wright D, Bezsonova I. USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms. Cell Chemical Biology. PMID 29056420 DOI: 10.1016/J.Chembiol.2017.09.004  0.01
2017 Grady LM, Szczepaniak R, Murelli RP, Masaoka T, Le Grice SFJ, Wright DL, Weller SK. The exonuclease activity of HSV-1 UL12 is required for the production of viral DNA that can be packaged to produce infectious virus. Journal of Virology. PMID 28956767 DOI: 10.1128/Jvi.01380-17  0.01
2017 Haney SL, Allen C, Varney ML, Dykstra KM, Falcone ER, Colligan SH, Hu Q, Aldridge AM, Wright DL, Wiemer AJ, Holstein SA. Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells. Oncotarget. PMID 28636534 DOI: 10.18632/oncotarget.18543  0.16
2017 Hoody J, Alverson JB, Keshipeddy S, Barney PA, Walker L, Anderson AC, Wright DL, Priestley ND. Pharmaceutical analysis of a novel propargyl-linked antifolate antibiotic in the mouse. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1051: 54-59. PMID 28314188 DOI: 10.1016/J.Jchromb.2017.02.026  0.8
2016 G-Dayanandan N, Scocchera EW, Keshipeddy S, Jones HF, Anderson AC, Wright DL. Direct Substitution of Arylalkynyl Carbinols Provides Access to Diverse Terminal Acetylene Building Blocks. Organic Letters. PMID 27959567 DOI: 10.1021/Acs.Orglett.6B03438  0.8
2016 Reeve SM, Scocchera EW, G-Dayanadan N, Keshipeddy S, Krucinska J, Hajian B, Ferreira J, Nailor M, Aeschlimann J, Wright DL, Anderson AC. MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chemical Biology. PMID 27939900 DOI: 10.1016/J.Chembiol.2016.11.007  0.8
2016 Li J, Falcone ER, Holstein SA, Anderson AC, Wright DL, Wiemer AJ. Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis. Pharmacological Research. PMID 27663262 DOI: 10.1016/J.Phrs.2016.09.020  0.8
2016 Lombardo MN, G-Dayanandan N, Wright DL, Anderson AC. Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates. Acs Infectious Diseases. 2: 149-56. PMID 27624966 DOI: 10.1021/Acsinfecdis.5B00129  0.8
2016 Hajian B, Scocchera E, Keshipeddy S, G-Dayanandan N, Shoen C, Krucinska J, Reeve S, Cynamon M, Anderson AC, Wright DL. Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis. Plos One. 11: e0161740. PMID 27580226 DOI: 10.1371/Journal.Pone.0161740  0.8
2016 Scocchera E, Reeve SM, Keshipeddy S, Lombardo MN, Hajian B, Sochia AE, Alverson JB, Priestley ND, Anderson AC, Wright DL. Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens. Acs Medicinal Chemistry Letters. 7: 692-6. PMID 27437079 DOI: 10.1021/Acsmedchemlett.6B00120  0.8
2016 Estrada A, Wright DL, Anderson AC. Antibacterial Antifolates: From Development through Resistance to the Next Generation. Cold Spring Harbor Perspectives in Medicine. PMID 27352799 DOI: 10.1101/Cshperspect.A028324  0.8
2016 Reeve SM, Scocchera E, Ferreira J, G-Dayanandan N, Keshipeddy S, Wright DL, Anderson AC. Charged propargyl-linked antifolates reveal mechanisms of antifolate resistance and inhibit trimethoprim-resistant MRSA strains possessing clinically relevant mutations. Journal of Medicinal Chemistry. PMID 27308944 DOI: 10.1021/Acs.Jmedchem.6B00688  0.8
2016 Chopra A, Bond MJ, Bleiler M, Yeagley M, Wright D, Giardina C. Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301. Plos One. 11: e0153818. PMID 27097159 DOI: 10.1371/Journal.Pone.0153818  0.8
2016 Lombardo MN, G-Dayanandan N, Wright DL, Anderson AC. Crystal structures of the resistance-conferring dfrA1 reveal that propargyl-linked antifolates are potent inhibitors Acs Infectious Diseases. 149-156. DOI: 10.2210/Pdb5Ecx/Pdb  0.8
2016 Lombardo MN, G-Dayanandan N, Wright DL, Anderson AC. Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates Acs Infectious Diseases. 2: 149-156. DOI: 10.1021/acsinfecdis.5b00129  0.64
2015 Anderson AC, Wright DL. The challenge of resistance in antimicrobial drug development. Future Microbiology. 10: 1709-10. PMID 26597424 DOI: 10.2217/Fmb.15.75  0.8
2015 Keshipeddy S, Reeve SM, Anderson AC, Wright DL. Non-racemic Antifolates Stereo-selectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus. Journal of the American Chemical Society. PMID 26098608 DOI: 10.1021/Jacs.5B01442  0.8
2015 Heidari-Torkabadi H, Che T, Lombardo MN, Wright DL, Anderson AC, Carey PR. Measuring propargyl-linked drug populations inside bacterial cells, and their interaction with a dihydrofolate reductase target, by Raman microscopy. Biochemistry. 54: 2719-26. PMID 25871808 DOI: 10.1021/Acs.Biochem.5B00202  0.8
2015 Cao L, Kuratnik A, Xu W, Gibson JD, Kolling F, Falcone ER, Ammar M, Van Heyst MD, Wright DL, Nelson CE, Giardina C. Development of intestinal organoids as tissue surrogates: cell composition and the epigenetic control of differentiation. Molecular Carcinogenesis. 54: 189-202. PMID 24115167 DOI: 10.1002/Mc.22089  0.8
2015 VanHeyst MD, Wright DL. The frondosins: An unusual synthetic and stereochemical journey European Journal of Organic Chemistry. 2015: 1387-1401. DOI: 10.1002/Ejoc.201403116  0.8
2014 Lamb KM, Lombardo MN, Alverson J, Priestley ND, Wright DL, Anderson AC. Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity. Antimicrobial Agents and Chemotherapy. 58: 7484-91. PMID 25288083 DOI: 10.1128/Aac.03555-14  0.8
2014 Anderson AC, Wright DL. Antifolate agents: a patent review (2010 - 2013). Expert Opinion On Therapeutic Patents. 24: 687-97. PMID 24655343 DOI: 10.1517/13543776.2014.898062  0.8
2014 Ononye SN, Vanheyst MD, Giardina C, Wright DL, Anderson AC. Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells. Bioorganic & Medicinal Chemistry. 22: 2188-93. PMID 24613456 DOI: 10.1016/J.Bmc.2014.02.018  0.8
2014 Oblak EZ, VanHeyst MD, Li J, Wiemer AJ, Wright DL. Cyclopropene cycloadditions with annulated furans: total synthesis of (+)- and (-)-frondosin B and (+)-frondosin A. Journal of the American Chemical Society. 136: 4309-15. PMID 24575795 DOI: 10.1021/Ja413106T  0.8
2014 G-Dayanandan N, Paulsen JL, Viswanathan K, Keshipeddy S, Lombardo MN, Zhou W, Lamb KM, Sochia AE, Alverson JB, Priestley ND, Wright DL, Anderson AC. Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata. Journal of Medicinal Chemistry. 57: 2643-56. PMID 24568657 DOI: 10.1021/Jm401916J  0.8
2014 Carreira EM, Ebner C, Oblak EZ, VanHeyst MD, Li J, Wiemer AJ, Wright DL. Synthesis of (+)- and (–)-Frondosin B Synfacts. 10: 558-558. DOI: 10.1055/S-0033-1339074  0.48
2014 Wright DL, Van Heyst MD, Oblak EZ. Oxabicyclic building blocks as key intermediates in the synthesis of the natural products (-)-platensimycin and (+)-frondosin A Strategies and Tactics in Organic Synthesis. 10: 155-181. DOI: 10.1016/B978-0-12-417185-5.00007-7  0.8
2013 Ononye SN, VanHeyst MD, Oblak EZ, Zhou W, Ammar M, Anderson AC, Wright DL. Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors. Acs Medicinal Chemistry Letters. 4: 757-61. PMID 24900743 DOI: 10.1021/Ml400158K  0.8
2013 Lamb KM, G-Dayanandan N, Wright DL, Anderson AC. Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase. Biochemistry. 52: 7318-26. PMID 24053334 DOI: 10.1021/Bi400852H  0.8
2013 VanHeyst MD, Oblak EZ, Wright DL. Stereodivergent resolution of oxabicyclic ketones: preparation of key intermediates for platensimycin and other natural products. The Journal of Organic Chemistry. 78: 10555-9. PMID 24047457 DOI: 10.1021/Jo4017502  0.8
2013 Cooper HD, Wright DL. The tandem ring opening/ring closing metathesis route to oxaspirocycles: an approach to phelligridin G. Molecules (Basel, Switzerland). 18: 2438-48. PMID 23429417 DOI: 10.3390/Molecules18022438  0.8
2013 Chopra AS, Kuratnik A, Scocchera EW, Wright DL, Giardina C. Identification of novel compounds that enhance colon cancer cell sensitivity to inflammatory apoptotic ligands. Cancer Biology & Therapy. 14: 436-49. PMID 23377828 DOI: 10.4161/Cbt.23787  0.8
2013 Paulsen JL, Viswanathan K, Wright DL, Anderson AC. Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species. Bioorganic & Medicinal Chemistry Letters. 23: 1279-84. PMID 23375226 DOI: 10.1016/J.Bmcl.2013.01.008  0.8
2013 Zhou W, Scocchera EW, Wright DL, Anderson AC. Antifolates as effective antimicrobial agents: New generations of trimethoprim analogs Medchemcomm. 4: 908-915. DOI: 10.1039/C3Md00104K  0.8
2012 Viswanathan K, Hoover DJ, Hwang J, Wisniewski ML, Ikonne US, Bahr BA, Wright DL. Nonpeptidic lysosomal modulators derived from z-phe-ala-diazomethylketone for treating protein accumulation diseases. Acs Medicinal Chemistry Letters. 3: 920-4. PMID 24900408 DOI: 10.1021/Ml300197H  0.8
2012 Ononye SN, van Heyst M, Falcone EM, Anderson AC, Wright DL. Toward isozyme-selective inhibitors of histone deacetylase as therapeutic agents for the treatment of cancer. Pharmaceutical Patent Analyst. 1: 207-21. PMID 24163736 DOI: 10.4155/Ppa.12.21  0.8
2012 Viswanathan K, Ononye SN, Cooper HD, Kyle Hadden M, Anderson AC, Wright DL. Viridin analogs derived from steroidal building blocks. Bioorganic & Medicinal Chemistry Letters. 22: 6919-22. PMID 23040731 DOI: 10.1016/J.Bmcl.2012.09.015  0.8
2012 Oblak EZ, Bolstad ES, Ononye SN, Priestley ND, Hadden MK, Wright DL. The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs. Organic & Biomolecular Chemistry. 10: 8597-604. PMID 23032214 DOI: 10.1039/C2Ob26553B  0.8
2012 Zhou W, Viswanathan K, Hill D, Anderson AC, Wright DL. Acetylenic linkers in lead compounds: a study of the stability of the propargyl-linked antifolates. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 2002-8. PMID 22815313 DOI: 10.1124/Dmd.112.046870  0.8
2012 Frey KM, Viswanathan K, Wright DL, Anderson AC. Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance. Antimicrobial Agents and Chemotherapy. 56: 3556-62. PMID 22491688 DOI: 10.1128/Aac.06263-11  0.8
2012 Viswanathan K, Frey KM, Scocchera EW, Martin BD, Swain Iii PW, Alverson JB, Priestley ND, Anderson AC, Wright DL. Toward new therapeutics for skin and soft tissue infections: propargyl-linked antifolates are potent inhibitors of MRSA and Streptococcus pyogenes. Plos One. 7: e29434. PMID 22347365 DOI: 10.1371/Journal.Pone.0029434  0.8
2012 Zheng X, Gessel MM, Wisniewski ML, Viswanathan K, Wright DL, Bahr BA, Bowers MT. Z-Phe-Ala-diazomethylketone (PADK) disrupts and remodels early oligomer states of the Alzheimer disease Aβ42 protein. The Journal of Biological Chemistry. 287: 6084-8. PMID 22253440 DOI: 10.1074/Jbc.C111.328575  0.8
2012 Luesse SB, Wells G, Miller J, Bolstad E, Bergmeier SC, McMills MC, Priestley ND, Wright DL. Synthesis of a functionalized oxabicyclo[2.2.1]-heptene-based chemical library. Combinatorial Chemistry & High Throughput Screening. 15: 81-9. PMID 21774767 DOI: 10.2174/138620712798280835  0.8
2011 Wright DL, Anderson AC. Antifolate agents: a patent review (2006 - 2010). Expert Opinion On Therapeutic Patents. 21: 1293-308. PMID 21619471 DOI: 10.1517/13543776.2011.587804  0.8
2011 Oblak EZ, G-Dayanandan N, Wright DL. Tandem metathesis reactions of oxabicyclo[2.2.1]heptenes: studies on the spirocyclic core of cyclopamine. Organic Letters. 13: 2433-5. PMID 21456515 DOI: 10.1021/Ol200706F  0.8
2011 Oblak EZ, Wright DL. Highly substituted oxabicyclic derivatives from furan: synthesis of (±)-platensimycin. Organic Letters. 13: 2263-5. PMID 21452821 DOI: 10.1021/Ol2005775  0.8
2010 Phillips JB, Smith AE, Kusche BR, Bessette BA, Swain PW, Bergmeier SC, McMills MC, Wright DL, Priestley ND. Natural product derivatives with bactericidal activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. Bioorganic & Medicinal Chemistry Letters. 20: 5936-8. PMID 20801034 DOI: 10.1016/J.Bmcl.2010.06.146  0.8
2010 Frey KM, Lombardo MN, Wright DL, Anderson AC. Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase. Journal of Structural Biology. 170: 93-7. PMID 20026215 DOI: 10.1016/J.Jsb.2009.12.011  0.8
2010 Sundstrom TJ, Wright DL. Azaviridins as new scaffolds for the development of PI-3K inhibitors Synlett. 2875-2878. DOI: 10.1055/S-0030-1259026  0.8
2010 Zhang Y, Oblak EZ, Bolstad ESD, Anderson AC, Jasinski JP, Butcher RJ, Wright DL. Synthetic and computational studies on liphagal: A natural product inhibitor of PI-3K Tetrahedron Letters. 51: 6120-6122. DOI: 10.1016/J.Tetlet.2010.09.058  0.8
2010 Orugunty RS, Wright DL, Battiste MA, Abboud KA. ChemInform Abstract: Silver-Promoted Reactions of Bicyclo[3.2.1]octadiene Derivatives. Cheminform. 33: no-no. DOI: 10.1002/chin.200243065  0.52
2009 Britton M, Lucas MM, Downey SL, Screen M, Pletnev AA, Verdoes M, Tokhunts RA, Amir O, Goddard AL, Pelphrey PM, Wright DL, Overkleeft HS, Kisselev AF. Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites. Chemistry & Biology. 16: 1278-89. PMID 20064438 DOI: 10.1016/J.Chembiol.2009.11.015  0.8
2009 Paulsen JL, Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans. Bioorganic & Medicinal Chemistry. 17: 4866-72. PMID 19560363 DOI: 10.1016/J.Bmc.2009.06.021  0.8
2009 Frey KM, Liu J, Lombardo MN, Bolstad DB, Wright DL, Anderson AC. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. Journal of Molecular Biology. 387: 1298-308. PMID 19249312 DOI: 10.1016/J.Jmb.2009.02.045  0.8
2009 Sundstrom TJ, Anderson AC, Wright DL. Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity. Organic & Biomolecular Chemistry. 7: 840-50. PMID 19225663 DOI: 10.1039/B819067B  0.8
2009 Liu J, Bolstad DB, Bolstad ES, Wright DL, Anderson AC. Towards new antifolates targeting eukaryotic opportunistic infections. Eukaryotic Cell. 8: 483-6. PMID 19168759 DOI: 10.1128/Ec.00298-08  0.8
2009 Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors. Chemical Biology & Drug Design. 73: 62-74. PMID 19152636 DOI: 10.1111/J.1747-0285.2008.00745.X  0.8
2008 Bolstad DB, Bolstad ES, Wright DL, Anderson AC. Dihydrofolate reductase inhibitors: developments in antiparasitic chemotherapy. Expert Opinion On Therapeutic Patents. 18: 143-57. PMID 20553119 DOI: 10.1517/13543776.18.2.143  0.8
2008 Beierlein JM, Frey KM, Bolstad DB, Pelphrey PM, Joska TM, Smith AE, Priestley ND, Wright DL, Anderson AC. Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase. Journal of Medicinal Chemistry. 51: 7532-40. PMID 19007108 DOI: 10.1021/Jm800776A  0.8
2008 Bolstad DB, Bolstad ES, Frey KM, Wright DL, Anderson AC. Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium. Journal of Medicinal Chemistry. 51: 6839-52. PMID 18834108 DOI: 10.1021/Jm8009124  0.8
2008 Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase. Chemistry & Biology. 15: 990-6. PMID 18804036 DOI: 10.1016/J.Chembiol.2008.07.013  0.8
2008 Luesse SB, Wells G, Nayek A, Smith AE, Kusche BR, Bergmeier SC, McMills MC, Priestley ND, Wright DL. Natural products in parallel synthesis: triazole libraries of nonactic acid. Bioorganic & Medicinal Chemistry Letters. 18: 3946-9. PMID 18585037 DOI: 10.1016/J.Bmcl.2008.06.020  0.8
2008 Schormann N, Senkovich O, Walker K, Wright DL, Anderson AC, Rosowsky A, Ananthan S, Shinkre B, Velu S, Chattopadhyay D. Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function. Proteins. 73: 889-901. PMID 18536013 DOI: 10.1002/Prot.22115  0.8
2007 Pelphrey PM, Popov VM, Joska TM, Beierlein JM, Bolstad ES, Fillingham YA, Wright DL, Anderson AC. Highly efficient ligands for dihydrofolate reductase from Cryptosporidium hominis and Toxoplasma gondii inspired by structural analysis. Journal of Medicinal Chemistry. 50: 940-50. PMID 17269758 DOI: 10.1021/Jm061027H  0.8
2007 Pelphrey PM, Bolstad DB, Wright DL. Versatile oxabicyclic synthons: Studies on C8-oxygenated eunicellin diterpenes Synlett. 2647-2650. DOI: 10.1055/S-2007-986667  0.8
2006 Sperry JB, Wright DL. The application of cathodic reductions and anodic oxidations in the synthesis of complex molecules. Chemical Society Reviews. 35: 605-21. PMID 16791332 DOI: 10.1039/B512308A  0.8
2006 Popov VM, Chan DC, Fillingham YA, Atom Yee W, Wright DL, Anderson AC. Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative. Bioorganic & Medicinal Chemistry Letters. 16: 4366-70. PMID 16750361 DOI: 10.1016/J.Bmcl.2006.05.047  0.8
2006 Nikodinovic J, Dinges JM, Bergmeier SC, McMills MC, Wright DL, Priestley ND. Resolution of methyl nonactate by Rhodococcus erythropolis under aerobic and anaerobic conditions. Organic Letters. 8: 443-5. PMID 16435855 DOI: 10.1021/Ol052739P  0.8
2006 Battiste MA, Pelphrey PM, Wright DL. The cycloaddition strategy for the synthesis of natural products containing carbocyclic seven-membered rings. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 3438-47. PMID 16402402 DOI: 10.1002/Chem.200501083  0.8
2006 Sperry JB, Ghiviriga I, Wright DL. Electrochemical annulation of five-membered rings through dearomatization of furans and thiophenes. Chemical Communications (Cambridge, England). 194-6. PMID 16372103 DOI: 10.1039/B513532J  0.8
2006 Sperry JB, Wright DL. Annulated heterocycles through a radical-cation cyclization: synthetic and mechanistic studies Tetrahedron. 62: 6551-6557. DOI: 10.1016/J.Tet.2006.03.058  0.8
2005 Sperry JB, Wright DL. Furans, thiophenes and related heterocycles in drug discovery. Current Opinion in Drug Discovery & Development. 8: 723-40. PMID 16312148  0.8
2005 Enholm E, Joshi A, Wright DL. Photocurable hard and porous biomaterials from ROMP precursors cross-linked with diyl radicals. Bioorganic & Medicinal Chemistry Letters. 15: 5262-5. PMID 16203146 DOI: 10.1016/J.Bmcl.2005.08.060  0.8
2005 Sperry JB, Wright DL. The gem-dialkyl effect in electron transfer reactions: rapid synthesis of seven-membered rings through an electrochemical annulation. Journal of the American Chemical Society. 127: 8034-5. PMID 15926826 DOI: 10.1021/Ja051826+  0.8
2005 Couch RD, Browning RG, Honda T, Gribble GW, Wright DL, Sporn MB, Anderson AC. Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action. Bioorganic & Medicinal Chemistry Letters. 15: 2215-9. PMID 15837296 DOI: 10.1016/J.Bmcl.2005.03.031  0.8
2005 Pelphrey P, Jasinski J, Butcher RJ, Wright DL. Oxabicyclo[3.2.1]octane derivatives as highly reactive dienophiles: synthesis of bicyclo[5.n.0] systems. Organic Letters. 7: 423-5. PMID 15673255 DOI: 10.1021/Ol047725I  0.8
2005 Wright DL. Chapter 1 Furans as versatile synthons for target-oriented and diversity-oriented synthesis Progress in Heterocyclic Chemistry. 17: 1-32. DOI: 10.1016/S0959-6380(05)80323-X  0.8
2005 Sperry JB, Constanzo JR, Jasinski J, Butcher RJ, Wright DL. Studies on the Diels-Alder reaction of annulated furans: Application to the synthesis of substituted phenanthrenes Tetrahedron Letters. 46: 2789-2793. DOI: 10.1016/J.Tetlet.2005.02.148  0.8
2005 Sperry JB, Wright DL. Synthesis of the hamigeran skeleton through an electro-oxidative coupling reaction Tetrahedron Letters. 46: 411-414. DOI: 10.1016/J.Tetlet.2004.11.108  0.8
2005 Pelphrey PM, Orugunty RS, Helmich RJ, Battiste MA, Wright DL. Halogenated oxabicyclo[3.2.1]octadiene building blocks: Elaboration of the dibromoenone European Journal of Organic Chemistry. 4296-4303. DOI: 10.1002/Ejoc.200500529  0.8
2004 Parks KP, Seidle H, Wright N, Sperry JB, Bieganowski P, Howitz K, Wright DL, Brenner C. Altered specificity of Hint-W123Q supports a role for Hint inhibition by ASW in avian sex determination. Physiological Genomics. 20: 12-4. PMID 15507519 DOI: 10.1152/Physiolgenomics.00204.2004  0.8
2004 Pelphrey PM, Abboud KA, Wright DL. New chiral building blocks from tetrabromocyclopropene and furan. The Journal of Organic Chemistry. 69: 6931-3. PMID 15387629 DOI: 10.1021/Jo048991C  0.8
2004 Sperry JB, Whitehead CR, Ghiviriga I, Walczak RM, Wright DL. Electrooxidative coupling of furans and silyl enol ethers: application to the synthesis of annulated furans. The Journal of Organic Chemistry. 69: 3726-34. PMID 15153002 DOI: 10.1021/Jo049889I  0.8
2004 Orugunty RS, Ghiviriga I, Abboud KA, Battiste MA, Wright DL. Bridged synthons from tetrabromocyclopropene: studies on the rearrangement of the primary Diels-Alder adduct with 2,5-dimethylfuran. The Journal of Organic Chemistry. 69: 570-2. PMID 14725477 DOI: 10.1021/Jo0352631  0.8
2004 Orugunty RS, Wright DL, Battiste MA, Helmich RJ, Abboud K. Bicyclo[3.2.1]octane synthons from cyclopropenes: functionalization of cycloadducts by nucleophilic additions. The Journal of Organic Chemistry. 69: 406-16. PMID 14725454 DOI: 10.1021/Jo035240M  0.8
2004 Batson WA, Abboud KA, Battiste MA, Wright DL. Synthesis of versatile bicyclo[5.4.0]undecane systems from tetrachlorocyclopropene Tetrahedron Letters. 45: 2093-2096. DOI: 10.1016/J.Tetlet.2004.01.055  0.8
2003 Robotham CV, Baker C, Cuevas B, Abboud K, Wright DL. A multi-component reaction (MCR) approach to the synthesis of highly diverse polymers with polypeptide-like features. Molecular Diversity. 6: 237-44. PMID 15068087 DOI: 10.1023/B:Modi.0000006777.63423.40  0.52
2002 Usher LC, Estrella-Jimenez M, Ghiviriga I, Wright DL. Synthesis of functionalized pyrans by domino metathesis reaction of oxabicyclo derivatives: dramatic effect of remote substituents on reactivity and selectivity. Angewandte Chemie (International Ed. in English). 41: 4560-2. PMID 12458538 DOI: 10.1002/1521-3773(20021202)41:23<4560::Aid-Anie4560>3.0.Co;2-B  0.36
2002 Whitehead CR, Sessions EH, Ghiviriga I, Wright DL. Two-step electrochemical annulation for the assembly of polycyclic systems. Organic Letters. 4: 3763-5. PMID 12375938 DOI: 10.1021/Ol026771K  0.8
2002 Orugunty RS, Wright DL, Battiste MA, Abboud KA. Silver-promoted reactions of bicyclo[3.2.1]octadiene derivatives. Organic Letters. 4: 1997-2000. PMID 12049501 DOI: 10.1021/Ol0258740  0.8
2002 McMills MC, Wright DL, Weekly RM. Synthesis of highly functionalized arene systems. Novel selectivities of intra- and intermolecular Friedel-Crafts reactions Synthetic Communications. 32: 2417-2425. DOI: 10.1081/Scc-120006014  0.8
2002 Wright DL, Robotham CV, Aboud K. Studies on the sequential multi-component coupling/Diels-Alder cycloaddition reaction Tetrahedron Letters. 43: 943-946. DOI: 10.1016/S0040-4039(01)02299-7  0.8
2001 Wright DL, Usher LC, Estrella-Jimenez M. Unusual influence of substituents on ring-opening metathesis reactions. Organic Letters. 3: 4275-7. PMID 11784196 DOI: 10.1021/Ol016936+  0.8
1999 Wright DL, Whitehead CR, Sessions EH, Ghiviriga I, Frey DA. Studies on inducers of nerve growth factor: Synthesis of the cyathin core Organic Letters. 1: 1535-1538. PMID 10836021 DOI: 10.1021/Ol991032Y  0.8
1999 Wender PA, Koehler MFT, Wright DL, Irie K. Mapping phorbol ester binding domains of protein kinase C (PKC): The design, synthesis and biological activity of novel phorbol ester dimers Synthesis. 1401-1406. DOI: 10.1055/S-1999-3656  0.8
1999 Wright DL, McMills MC. Intramolecular aziridination: Decomposition of diazoamides with tethered imino bonds Organic Letters. 1: 667-670. DOI: 10.1021/Ol990750H  0.8
1997 Wender PA, Handy ST, Wright DL. Towards the ideal synthesis Chemistry and Industry (London). X-XI.  0.8
1996 McMills MC, Wright DL, Zubkowski JD, Valente EJ. Facile generation of aziridines from the reaction of α-diazoamides with tethered oximino-ethers Tetrahedron Letters. 37: 7205-7208. DOI: 10.1016/0040-4039(96)01567-5  0.8
1996 Wright DL, Weekly RM, Groff R, McMills MC. A metallocarbenoid approach to the formation of spirocyclic ammonium ylides leading to the preparation of medium-sized azacane rings Tetrahedron Letters. 37: 2165-2168. DOI: 10.1016/0040-4039(96)00221-3  0.8
1994 McMills MC, Zhuang L, Wright DL, Watt W. A carbonyl-ylide approach to the tigliane diterpenes Tetrahedron Letters. 35: 8311-8314. DOI: 10.1016/S0040-4039(00)74394-2  0.8
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