Christopher M. Dobson - Publications

Affiliations: 
University of Cambridge, Cambridge, England, United Kingdom 
Area:
structures and properties of biological molecules
Website:
http://www.ch.cam.ac.uk/staff/cmd.html

358 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Meisl G, Michaels TCT, Arosio P, Vendruscolo M, Dobson CM, Knowles TPJ. Dynamics and Control of Peptide Self-Assembly and Aggregation. Advances in Experimental Medicine and Biology. 1174: 1-33. PMID 31713195 DOI: 10.1007/978-981-13-9791-2_1  0.96
2019 Delivoria DC, Chia S, Habchi J, Perni M, Matis I, Papaevgeniou N, Reczko M, Chondrogianni N, Dobson CM, Vendruscolo M, Skretas G. Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation. Science Advances. 5: eaax5108. PMID 31663025 DOI: 10.1126/sciadv.aax5108  0.96
2019 Wang X, Kirkpatrick JP, Launay HMM, de Simone A, Häussinger D, Dobson CM, Vendruscolo M, Cabrita LD, Waudby CA, Christodoulou J. Probing the dynamic stalk region of the ribosome using solution NMR. Scientific Reports. 9: 13528. PMID 31537834 DOI: 10.1038/s41598-019-49190-1  0.96
2019 Ng JSW, Hanspal MA, Matharu NS, Barros TP, Esbjörner EK, Wilson MR, Yerbury JJ, Dobson CM, Kumita JR. Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis. Biochemistry. PMID 31529970 DOI: 10.1021/acs.biochem.9b00592  0.36
2019 Lindstedt PR, Aprile FA, Matos MJ, Perni M, Bertoldo JB, Bernardim B, Peter Q, Jiménez-Osés G, Knowles TPJ, Dobson CM, Corzana F, Vendruscolo M, Bernardes GJL. Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification. Acs Central Science. 5: 1417-1424. PMID 31482124 DOI: 10.1021/acscentsci.9b00467  0.96
2019 Agerschou ED, Flagmeier P, Saridaki T, Galvagnion C, Komnig D, Heid L, Prasad V, Shaykhalishahi H, Willbold D, Dobson CM, Voigt A, Falkenbürger B, Hoyer W, Buell AK. An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils. Elife. 8. PMID 31389332 DOI: 10.7554/eLife.46112  0.52
2019 Mannini B, Vecchi G, Labrador-Garrido A, Fabre B, Fani G, Munoz Franco J, Lilley KS, Pozo D, Vendruscolo M, Chiti F, Dobson CM, Roodveldt C. Differential interactome and innate immune response activation of two structurally distinct misfolded protein oligomers. Acs Chemical Neuroscience. PMID 31313906 DOI: 10.1021/acschemneuro.9b00088  0.96
2019 Waudby CA, Dobson CM, Christodoulou J. Nature and Regulation of Protein Folding on the Ribosome. Trends in Biochemical Sciences. PMID 31301980 DOI: 10.1016/j.tibs.2019.06.008  0.92
2019 Laine RF, Sinnige T, Ma KY, Haack AJ, Poudel C, Gaida P, Curry N, Perni M, Nollen EAA, Dobson CM, Vendruscolo M, Kaminski Schierle GS, Kaminski CF. Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans. Acs Chemical Biology. PMID 31246415 DOI: 10.1021/acschembio.9b00354  0.96
2019 Sinnige T, Ciryam P, Casford S, Dobson CM, de Bono M, Vendruscolo M. Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response. Plos One. 14: e0217746. PMID 31150491 DOI: 10.1371/journal.pone.0217746  0.96
2019 Froula JM, Castellana-Cruz M, Anabtawi NM, Camino JD, Chen SW, Thrasher DR, Freire J, Yazdi AA, Fleming S, Dobson CM, Kumita JR, Cremades N, Volpicelli-Daley LA. Defining α-synuclein species responsible for Parkinson disease phenotypes in mice. The Journal of Biological Chemistry. PMID 31142553 DOI: 10.1074/jbc.RA119.007743  0.4
2019 Vivoli Vega M, Cascella R, Chen SW, Fusco G, De Simone A, Dobson CM, Cecchi C, Chiti F. The toxicity of misfolded protein oligomers is independent of their secondary structure. Acs Chemical Biology. PMID 31074957 DOI: 10.1021/acschembio.9b00324  0.52
2019 Cascella R, Perni M, Chen SW, Fusco G, Cecchi C, Vendruscolo M, Chiti F, Dobson CM, De Simone A. Probing the origin of the toxicity of oligomeric aggregates of α-synuclein with antibodies. Acs Chemical Biology. PMID 31050886 DOI: 10.1021/acschembio.9b00312  0.96
2019 Scheidt T, Łapińska U, Kumita JR, Whiten DR, Klenerman D, Wilson MR, Cohen SIA, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ, Arosio P. Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates. Science Advances. 5: eaau3112. PMID 31001578 DOI: 10.1126/sciadv.aau3112  0.96
2019 Ahmed N, Sormanni P, Ciryam P, Vendruscolo M, Dobson CM, O'Brien EP. Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming. Scientific Reports. 9: 6256. PMID 31000737 DOI: 10.1038/s41598-019-42348-x  0.96
2019 Yerbury JJ, Ooi L, Blair IP, Ciryam P, Dobson CM, Vendruscolo M. The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS. Neuroscience Letters. PMID 30953736 DOI: 10.1016/j.neulet.2019.04.001  0.96
2019 De S, Wirthensohn DC, Flagmeier P, Hughes C, Aprile FA, Ruggeri FS, Whiten DR, Emin D, Xia Z, Varela JA, Sormanni P, Kundel F, Knowles TPJ, Dobson CM, Bryant C, et al. Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms. Nature Communications. 10: 1541. PMID 30948723 DOI: 10.1038/s41467-019-09477-3  0.96
2019 Dobson CM, Knowles TPJ, Vendruscolo M. The Amyloid Phenomenon and Its Significance in Biology and Medicine. Cold Spring Harbor Perspectives in Biology. PMID 30936117 DOI: 10.1101/cshperspect.a033878  0.96
2019 Liu X, Toprakcioglu Z, Dear AJ, Levin A, Ruggeri FS, Taylor CG, Hu M, Kumita JR, Andreasen M, Dobson CM, Shimanovich U, Knowles TPJ. Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules. Macromolecular Rapid Communications. e1800898. PMID 30840348 DOI: 10.1002/marc.201800898  0.92
2019 Weiffert T, Meisl G, Flagmeier P, De S, Dunning CJR, Frohm B, Zetterberg H, Blennow K, Portelius E, Klenerman D, Dobson CM, Knowles TPJ, Linse S. Increased secondary nucleation underlies accelerated aggregation of the four-residue N-terminally truncated Aβ42 species Aβ5-42. Acs Chemical Neuroscience. PMID 30793584 DOI: 10.1021/acschemneuro.8b00676  0.92
2019 Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, ... ... Dobson CM, et al. Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes. Nature Communications. 10: 225. PMID 30644384 DOI: 10.1038/s41467-018-07699-5  0.96
2019 Ahn M, Lee BI, Chia S, Habchi J, Kumita JR, Vendruscolo M, Dobson CM, Park CB. Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation. Chemical Communications (Cambridge, England). PMID 30632567 DOI: 10.1039/c8cc09288e  0.96
2019 Andreasen M, Meisl G, Taylor JD, Michaels TCT, Levin A, Otzen DE, Chapman MR, Dobson CM, Matthews SJ, Knowles TPJ. Physical Determinants of Amyloid Assembly in Biofilm Formation. Mbio. 10. PMID 30622185 DOI: 10.1128/mBio.02279-18  0.92
2018 Perni M, Casford S, Aprile FA, Nollen EA, Knowles TPJ, Vendruscolo M, Dobson CM. Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform. Journal of Visualized Experiments : Jove. PMID 30582580 DOI: 10.3791/58643  0.96
2018 Lee JE, Sang JC, Rodrigues M, Carr AR, Horrocks MH, De S, Bongiovanni MN, Flagmeier P, Dobson CM, Wales DJ, Lee SF, Klenerman D. Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale. Nano Letters. PMID 30380895 DOI: 10.1021/acs.nanolett.8b02916  0.52
2018 Iljina M, Dear AJ, Garcia GA, De S, Tosatto L, Flagmeier P, Whiten DR, Michaels TCT, Frenkel D, Dobson CM, Knowles TPJ, Klenerman D. Quantifying Co-Oligomer Formation by α-Synuclein. Acs Nano. PMID 30371053 DOI: 10.1021/acsnano.8b03575  0.92
2018 Dear AJ, Šarić A, Michaels TCT, Dobson CM, Knowles TPJ. Statistical Mechanics of Globular Oligomer Formation by Protein Molecules. The Journal of Physical Chemistry. B. PMID 30336667 DOI: 10.1021/acs.jpcb.8b07805  0.92
2018 Chia S, Habchi J, Michaels TCT, Cohen SIA, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M. SAR by kinetics for drug discovery in protein misfolding diseases. Proceedings of the National Academy of Sciences of the United States of America. PMID 30257937 DOI: 10.1073/pnas.1807884115  0.96
2018 Ruggeri FS, Charmet J, Kartanas T, Peter Q, Chia S, Habchi J, Dobson CM, Vendruscolo M, Knowles TPJ. Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity. Nature Communications. 9: 3890. PMID 30250131 DOI: 10.1038/s41467-018-06345-4  0.96
2018 van der Wateren IM, Knowles TPJ, Buell AK, Dobson CM, Galvagnion C. C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH. Chemical Science. 9: 5506-5516. PMID 30061982 DOI: 10.1039/c8sc01109e  0.92
2018 Horrocks M, Whiten DR, Zuo Y, Calo L, Choi ML, De S, Flagmeier P, Wirthensohn DC, Kundel F, Lee SF, Dobson C, Gandhi S, Spillantini M, Klenerman D, Ranasinghe RT, et al. Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells. Chembiochem : a European Journal of Chemical Biology. PMID 30051958 DOI: 10.1002/cbic.201800209  0.52
2018 Månsson C, van Cruchten RTP, Weininger U, Yang X, Cukalevski R, Arosio P, Dobson CM, Knowles TPJ, Akke M, Linse S, Emanuelsson C. Conserved S/T-residues of the human chaperone DNAJB6 are required for effective inhibition of Aβ42 amyloid fibril formation. Biochemistry. PMID 30024736 DOI: 10.1021/acs.biochem.8b00353  0.92
2018 Capitini C, Patel JR, Natalello A, D'Andrea C, Relini A, Jarvis JA, Birolo L, Peduzzo A, Vendruscolo M, Matteini P, Dobson CM, De Simone A, Chiti F. Structural differences between toxic and nontoxic HypF-N oligomers. Chemical Communications (Cambridge, England). PMID 30020284 DOI: 10.1039/c8cc03446j  0.96
2018 Mannini B, Habchi J, Chia SKR, Ruggeri FS, Perni M, Knowles TPJ, Dobson CM, Vendruscolo M. Stabilization and characterization of cytotoxic Aβ40 oligomers isolated from an aggregation reaction in the presence of zinc ions. Acs Chemical Neuroscience. PMID 29986583 DOI: 10.1021/acschemneuro.8b00141  0.96
2018 Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, ... ... Dobson CM, et al. Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. Acs Chemical Biology. PMID 29953201 DOI: 10.1021/acschembio.8b00466  0.96
2018 Brown JWP, Meisl G, Knowles TPJ, Buell AK, Dobson CM, Galvagnion C. Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils. Chemical Communications (Cambridge, England). PMID 29951679 DOI: 10.1039/c8cc03002b  0.92
2018 Whiten DR, Cox D, Horrocks MH, Taylor CG, De S, Flagmeier P, Tosatto L, Kumita JR, Ecroyd H, Dobson CM, Klenerman D, Wilson MR. Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers. Cell Reports. 23: 3492-3500. PMID 29924993 DOI: 10.1016/j.celrep.2018.05.074  0.52
2018 Zhang Y, Yates EV, Hong L, Saar KL, Meisl G, Dobson CM, Knowles TPJ. On-chip measurements of protein unfolding from direct observations of micron-scale diffusion. Chemical Science. 9: 3503-3507. PMID 29780480 DOI: 10.1039/c7sc04331g  0.92
2018 Wright MA, Aprile FA, Bellaiche MM, Michaels TCT, Müller T, Arosio P, Vendruscolo M, Dobson CM, Knowles TPJ. Cooperative assembly of Hsp70 subdomain clusters. Biochemistry. PMID 29763298 DOI: 10.1021/acs.biochem.8b00151  0.96
2018 Habchi J, Chia S, Galvagnion C, Michaels TCT, Bellaiche MMJ, Ruggeri FS, Sanguanini M, Idini I, Kumita JR, Sparr E, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M. Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes. Nature Chemistry. PMID 29736006 DOI: 10.1038/s41557-018-0031-x  0.96
2018 El Turk F, De Genst E, Guilliams T, Fauvet B, Hejjaoui M, Di Trani J, Chiki A, Mittermaier A, Vendruscolo M, Lashuel HA, Dobson CM. Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding. Protein Science : a Publication of the Protein Society. PMID 29603451 DOI: 10.1002/pro.3412  0.96
2018 Fusco G, Sanz-Hernandez M, Ruggeri FS, Vendruscolo M, Dobson CM, De Simone A. Molecular determinants of the interaction of EGCG with ordered and disordered proteins. Biopolymers. e23117. PMID 29603125 DOI: 10.1002/bip.23117  0.96
2018 Cohen SIA, Cukalevski R, Michaels TCT, Šarić A, Törnquist M, Vendruscolo M, Dobson CM, Buell AK, Knowles TPJ, Linse S. Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide. Nature Chemistry. PMID 29581486 DOI: 10.1038/s41557-018-0023-x  0.96
2018 Herling TW, Levin A, Saar KL, Dobson CM, Knowles TPJ. Microfluidic approaches for probing amyloid assembly and behaviour. Lab On a Chip. PMID 29527600 DOI: 10.1039/c7lc01241a  0.92
2018 Michaels TCT, Šarić A, Habchi J, Chia S, Meisl G, Vendruscolo M, Dobson CM, Knowles TPJ. Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation. Annual Review of Physical Chemistry. PMID 29490200 DOI: 10.1146/annurev-physchem-050317-021322  0.96
2018 Perni M, Challa PK, Kirkegaard JB, Limbocker R, Koopman M, Hardenberg MC, Sormanni P, Müller T, Saar KL, Roode LWY, Habchi J, Vecchi G, Fernando NW, Casford S, Nollen EAA, ... ... Dobson CM, et al. Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery. Journal of Neuroscience Methods. PMID 29452179 DOI: 10.1016/j.jneumeth.2018.02.005  0.96
2018 Cox D, Whiten DR, Brown J, Horrocks MH, San Gil R, Dobson CM, Klenerman D, van Oijen AM, Ecroyd H. The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity. The Journal of Biological Chemistry. PMID 29382725 DOI: 10.1074/jbc.M117.813865  0.32
2018 Shimanovich U, Pinotsi D, Shimanovich K, Yu N, Bolisetty S, Adamcik J, Mezzenga R, Charmet J, Vollrath F, Gazit E, Dobson CM, Schierle GK, Holland C, Kaminski CF, Knowles TPJ. Biophotonics of Native Silk Fibrils. Macromolecular Bioscience. PMID 29377575 DOI: 10.1002/mabi.201700295  0.92
2018 Yang J, Dear AJ, Michaels TCT, Dobson CM, Knowles TPJ, Wu S, Perrett S. Direct observation of oligomerization by single molecule fluorescence reveals a multi-step aggregation mechanism for the yeast prion protein Ure2. Journal of the American Chemical Society. PMID 29357227 DOI: 10.1021/jacs.7b10439  0.92
2018 Varela JA, Rodrigues M, De S, Flagmeier P, Gandhi S, Dobson CM, Klenerman D, Lee S. Optical structural analysis of individual α-synuclein oligomers. Angewandte Chemie (International Ed. in English). PMID 29342318 DOI: 10.1002/anie.201710779  0.52
2018 Gang H, Galvagnion C, Meisl G, Müller T, Buell AK, Levin A, Dobson CM, Mu BZ, Knowles TPJ. A microfluidic diffusion platform for characterizing the size of lipid vesicles and the thermodynamics of protein-lipid interactions. Analytical Chemistry. PMID 29313342 DOI: 10.1021/acs.analchem.7b04820  0.92
2018 Kundel F, De S, Flagmeier P, Horrocks MH, Kjaergaard M, Shammas SL, Jackson SE, Dobson CM, Klenerman D. Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity. Acs Chemical Biology. PMID 29300447 DOI: 10.1021/acschembio.7b01039  0.52
2017 Fusco G, Chen SW, Williamson PTF, Cascella R, Perni M, Jarvis JA, Cecchi C, Vendruscolo M, Chiti F, Cremades N, Ying L, Dobson CM, De Simone A. Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers. Science (New York, N.Y.). 358: 1440-1443. PMID 29242346 DOI: 10.1126/science.aan6160  0.96
2017 Drews A, De S, Flagmeier P, Wirthensohn DC, Chen WH, Whiten DR, Rodrigues M, Vincke C, Muyldermans S, Paterson RW, Slattery CF, Fox NC, Schott JM, Zetterberg H, Dobson CM, et al. Inhibiting the Ca2+ Influx Induced by Human CSF. Cell Reports. 21: 3310-3316. PMID 29241555 DOI: 10.1016/j.celrep.2017.11.057  0.52
2017 Meisl G, Rajah L, Cohen SAI, Pfammatter M, Šarić A, Hellstrand E, Buell AK, Aguzzi A, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ. Scaling behaviour and rate-determining steps in filamentous self-assembly. Chemical Science. 8: 7087-7097. PMID 29147538 DOI: 10.1039/c7sc01965c  0.96
2017 Perni M, Aprile FA, Casford S, Mannini B, Sormanni P, Dobson CM, Vendruscolo M. Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles. Scientific Reports. 7: 15045. PMID 29118344 DOI: 10.1038/s41598-017-13755-9  0.96
2017 Gregory JM, Whiten DR, Brown RA, Barros TP, Kumita JR, Yerbury JJ, Satapathy S, McDade K, Smith C, Luheshi LM, Dobson CM, Wilson MR. Clusterin protects neurons against intracellular proteotoxicity. Acta Neuropathologica Communications. 5: 81. PMID 29115989 DOI: 10.1186/s40478-017-0481-1  0.4
2017 Ahn M, Waudby CA, Bernardo-Gancedo A, De Genst E, Dhulesia A, Salvatella X, Christodoulou J, Dobson CM, Kumita JR. Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation. Scientific Reports. 7: 15018. PMID 29101328 DOI: 10.1038/s41598-017-14739-5  0.92
2017 Villadiego J, Labrador-Garrido A, Franco JM, Leal-Lasarte M, De Genst EJ, Dobson CM, Pozo D, Toledo-Aral JJ, Roodveldt C. Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model. Glia. PMID 29024008 DOI: 10.1002/glia.23237  0.52
2017 Mason TO, Michaels TCT, Levin A, Dobson CM, Gazit E, Knowles TPJ, Buell AK. Thermodynamics of polypeptide supramolecular assembly in the short chain limit. Journal of the American Chemical Society. PMID 28994295 DOI: 10.1021/jacs.7b00229  0.92
2017 Meisl G, Yang X, Dobson CM, Linse S, Knowles TPJ. Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants. Chemical Science. 8: 4352-4362. PMID 28979758 DOI: 10.1039/c7sc00215g  0.92
2017 Pfammatter M, Andreasen M, Meisl G, Taylor CG, Adamcik J, Bolisetty S, Sanchez-Ferrer A, Klenerman D, Dobson CM, Mezzenga R, Knowles TPJ, Aguzzi AA, Hornemann S. Absolute Quantification of Amyloid Propagons by Digital Microfluidics. Analytical Chemistry. PMID 28972786 DOI: 10.1021/acs.analchem.7b03279  0.92
2017 Łapińska U, Saar KL, Yates EV, Herling TW, Müller T, Challa PK, Dobson CM, Knowles TPJ. Gradient-free determination of isoelectric points of proteins on chip. Physical Chemistry Chemical Physics : Pccp. PMID 28817152 DOI: 10.1039/c7cp01503h  0.92
2017 Shimanovich U, Michaels TCT, de Genst EJ, Matak-Vinkovic D, Dobson CM, Knowles TPJ. Sequential release of proteins from structured multishell microcapsules. Biomacromolecules. PMID 28792742 DOI: 10.1021/acs.biomac.7b00351  0.92
2017 Shimanovich U, Ruggeri FS, De Genst E, Adamcik J, Barros TP, Porter D, Müller T, Mezzenga R, Dobson CM, Vollrath F, Holland C, Knowles TPJ. Silk micrococoons for protein stabilisation and molecular encapsulation. Nature Communications. 8: 15902. PMID 28722016 DOI: 10.1038/ncomms15902  0.92
2017 Hanspal MA, Dobson CM, Yerbury JJ, Kumita JR. The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis. Biochimica Et Biophysica Acta. PMID 28711596 DOI: 10.1016/j.bbadis.2017.07.007  0.36
2017 Cremades N, Dobson CM. The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases. Neurobiology of Disease. PMID 28709995 DOI: 10.1016/j.nbd.2017.07.009  0.32
2017 Chia S, Flagmeier P, Habchi J, Lattanzi V, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M. Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates. Proceedings of the National Academy of Sciences of the United States of America. PMID 28698377 DOI: 10.1073/pnas.1700239114  0.96
2017 Aprile FA, Sormanni P, Perni M, Arosio P, Linse S, Knowles TPJ, Dobson CM, Vendruscolo M. Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method. Science Advances. 3: e1700488. PMID 28691099 DOI: 10.1126/sciadv.1700488  0.96
2017 Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, ... Dobson CM, et al. Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species. Bmc Biology. 15: 57. PMID 28673288 DOI: 10.1186/s12915-017-0390-6  0.96
2017 Kundra R, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M. Protein homeostasis of a metastable subproteome associated with Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28652376 DOI: 10.1073/pnas.1618417114  0.96
2017 Munke A, Persson J, Weiffert T, De Genst E, Meisl G, Arosio P, Carnerup A, Dobson CM, Vendruscolo M, Knowles TPJ, Linse S. Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication. Proceedings of the National Academy of Sciences of the United States of America. PMID 28584111 DOI: 10.1073/pnas.1700407114  0.96
2017 Chiti F, Dobson CM. Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade. Annual Review of Biochemistry. PMID 28498720 DOI: 10.1146/annurev-biochem-061516-045115  0.44
2017 Stroobants K, Kumita JR, Harris N, Chirgadze D, Dobson CM, Booth PJ, Vendruscolo M. Amyloid-like fibrils from an α-helical transmembrane protein. Biochemistry. PMID 28493669 DOI: 10.1021/acs.biochem.7b00157  0.96
2017 Fusco G, Pape T, Stephens AD, Mahou P, Costa AR, Kaminski CF, Schierle GSK, Vendruscolo M, Veglia G, Dobson CM, De Simone A. Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein. Nature Communications. 8: 15667. PMID 28492274 DOI: 10.1038/ncomms15667  0.96
2017 Flagmeier P, De S, Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, Knowles TPJ, Gandhi S, Dobson CM, Klenerman D. Ultrasensitive Measurement of Ca(2+) Influx into Lipid Vesicles Induced by Protein Aggregates. Angewandte Chemie (International Ed. in English). PMID 28474754 DOI: 10.1002/anie.201700966  0.92
2017 Ciryam P, Lambert-Smith IA, Bean DM, Freer R, Cid F, Tartaglia GG, Saunders DN, Wilson MR, Oliver SG, Morimoto RI, Dobson CM, Vendruscolo M, Favrin G, Yerbury JJ. Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396410 DOI: 10.1073/pnas.1613854114  0.96
2017 Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU. Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell. 168: 944. PMID 28235202 DOI: 10.1016/j.cell.2016.12.041  0.96
2017 Aprile FA, Arosio P, Fusco G, Chen SW, Kumita JR, Dhulesia A, Tortora P, Knowles TP, Vendruscolo M, Dobson CM, Cremades N. Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species. Biochemistry. PMID 28230968 DOI: 10.1021/acs.biochem.6b01178  0.96
2017 Perni M, Galvagnion C, Maltsev A, Meisl G, Müller MB, Challa PK, Kirkegaard JB, Flagmeier P, Cohen SI, Cascella R, Chen SW, Limboker R, Sormanni P, Heller GT, Aprile FA, ... ... Dobson CM, et al. A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096355 DOI: 10.1073/pnas.1610586114  0.96
2016 Šarić A, Buell AK, Meisl G, Michaels TCT, Dobson CM, Linse S, Knowles TPJ, Frenkel D. Physical determinants of the self-replication of protein fibrils. Nature Physics. 12: 874-880. PMID 31031819 DOI: 10.1038/nphys3828  0.92
2016 Habchi J, Chia S, Limbocker R, Mannini B, Ahn M, Perni M, Hansson O, Arosio P, Kumita JR, Challa PK, Cohen SI, Linse S, Dobson CM, Knowles TP, Vendruscolo M. Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28011763 DOI: 10.1073/pnas.1615613114  0.96
2016 Bongiovanni MN, Godet J, Horrocks MH, Tosatto L, Carr AR, Wirthensohn DC, Ranasinghe RT, Lee JE, Ponjavic A, Fritz JV, Dobson CM, Klenerman D, Lee SF. Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping. Nature Communications. 7: 13544. PMID 27929085 DOI: 10.1038/ncomms13544  0.32
2016 Ahn M, Hagan CL, Bernardo-Gancedo A, De Genst E, Newby FN, Christodoulou J, Dhulesia A, Dumoulin M, Robinson CV, Dobson CM, Kumita JR. The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme. Biophysical Journal. 111: 2358-2367. PMID 27926837 DOI: 10.1016/j.bpj.2016.10.028  0.52
2016 Brown JW, Buell AK, Michaels TC, Meisl G, Carozza J, Flagmeier P, Vendruscolo M, Knowles TP, Dobson CM, Galvagnion C. β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces. Scientific Reports. 6: 36010. PMID 27808107 DOI: 10.1038/srep36010  0.96
2016 Fusco G, Pape T, Stephens AD, Mahou P, Costa AR, Kaminski CF, Kaminski Schierle GS, Vendruscolo M, Veglia G, Dobson CM, De Simone A. Structural basis of synaptic vesicle assembly promoted by α-synuclein. Nature Communications. 7: 12563. PMID 27640673 DOI: 10.1038/ncomms12563  0.96
2016 Evangelisti E, Cascella R, Becatti M, Marrazza G, Dobson CM, Chiti F, Stefani M, Cecchi C. Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases. Scientific Reports. 6: 32721. PMID 27619987 DOI: 10.1038/srep32721  0.44
2016 Flagmeier P, Meisl G, Vendruscolo M, Knowles TP, Dobson CM, Buell AK, Galvagnion C. Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27573854 DOI: 10.1073/pnas.1604645113  0.96
2016 Freer R, Sormanni P, Vecchi G, Ciryam P, Dobson CM, Vendruscolo M. A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease. Science Advances. 2: e1600947. PMID 27532054 DOI: 10.1126/sciadv.1600947  0.96
2016 Zhang Y, Buell AK, Müller T, De Genst E, Benesch J, Dobson CM, Knowles TP. Protein aggregate-ligand binding assays based on microfluidic diffusional separation. Chembiochem : a European Journal of Chemical Biology. PMID 27472818 DOI: 10.1002/cbic.201600384  0.52
2016 Camilloni C, Bonetti D, Morrone A, Giri R, Dobson CM, Brunori M, Gianni S, Vendruscolo M. Towards a structural biology of the hydrophobic effect in protein folding. Scientific Reports. 6: 28285. PMID 27461719 DOI: 10.1038/srep28285  0.96
2016 Cascella R, Capitini C, Fani G, Dobson CM, Cecchi C, Chiti F. Quantification of the relative contributions of loss-of-function and gain-of-function mechanisms in TDP-43 proteinopathies. The Journal of Biological Chemistry. PMID 27445339 DOI: 10.1074/jbc.M116.737726  0.44
2016 Mason TO, Michaels TC, Levin A, Gazit E, Dobson CM, Buell AK, Knowles TP. Synthesis of non-equilibrium supra-molecular peptide polymers on a microfluidic platform. Journal of the American Chemical Society. PMID 27387359 DOI: 10.1021/jacs.6b04136  0.96
2016 Iljina M, Garcia GA, Dear AJ, Flint J, Narayan P, Michaels TC, Dobson CM, Frenkel D, Knowles TP, Klenerman D. Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms. Scientific Reports. 6: 28658. PMID 27346247 DOI: 10.1038/srep28658  0.52
2016 Galvagnion C, Brown JW, Ouberai MM, Flagmeier P, Vendruscolo M, Buell AK, Sparr E, Dobson CM. Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein. Proceedings of the National Academy of Sciences of the United States of America. PMID 27298346 DOI: 10.1073/pnas.1601899113  0.96
2016 Fusco G, De Simone A, Arosio P, Vendruscolo M, Veglia G, Dobson CM. Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity. Scientific Reports. 6: 27125. PMID 27273030 DOI: 10.1038/srep27125  0.96
2016 Angelova PR, Ludtmann MH, Horrocks MH, Negoda A, Cremades N, Klenerman D, Dobson CM, Wood NW, Pavlov EV, Gandhi S, Abramov AY. Ca2+ is a key factor in α-synuclein-induced neurotoxicity. Development (Cambridge, England). 143: e1.1. PMID 27190039 DOI: 10.1242/dev.139345  0.32
2016 Kakkar V, Månsson C, de Mattos EP, Bergink S, van der Zwaag M, van Waarde MA, Kloosterhuis NJ, Melki R, van Cruchten RT, Al-Karadaghi S, Arosio P, Dobson CM, Knowles TP, Bates GP, van Deursen JM, et al. The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model. Molecular Cell. PMID 27151442 DOI: 10.1016/j.molcel.2016.03.017  0.96
2016 El-Turk F, Newby F, de Genst EJ, Guilliams T, Sprules T, Mittermaier AK, Dobson CM, Vendruscolo M. Structural effects of two camelid nanobodies directed to distinct C-terminal epitopes on α-synuclein. Biochemistry. PMID 27096466 DOI: 10.1021/acs.biochem.6b00149  0.96
2016 Deckert A, Waudby CA, Wlodarski T, Wentink AS, Wang X, Kirkpatrick JP, Paton JF, Camilloni C, Kukic P, Dobson CM, Vendruscolo M, Cabrita LD, Christodoulou J. Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor. Proceedings of the National Academy of Sciences of the United States of America. PMID 27092002 DOI: 10.1073/pnas.1519124113  0.96
2016 Ciryam P, Kundra R, Freer R, Morimoto RI, Dobson CM, Vendruscolo M. A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27071083 DOI: 10.1073/pnas.1516604113  0.96
2016 Arosio P, Michaels TC, Linse S, Månsson C, Emanuelsson C, Presto J, Johansson J, Vendruscolo M, Dobson CM, Knowles TP. Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation. Nature Communications. 7: 10948. PMID 27009901 DOI: 10.1038/ncomms10948  0.96
2016 Pinotsi D, Michel CH, Buell AK, Laine RF, Mahou P, Dobson CM, Kaminski CF, Kaminski Schierle GS. Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons. Proceedings of the National Academy of Sciences of the United States of America. PMID 26993805 DOI: 10.1073/pnas.1516546113  0.52
2016 Angelova PR, Ludtmann MH, Horrocks MH, Negoda A, Cremades N, Klenerman D, Dobson CM, Wood NW, Pavlov EV, Gandhi S, Abramov AY. Calcium is a key factor in α-synuclein induced neurotoxicity. Journal of Cell Science. PMID 26989132 DOI: 10.1242/jcs.180737  0.32
2016 Wolff M, Mittag JJ, Herling TW, Genst ED, Dobson CM, Knowles TP, Braun D, Buell AK. Quantitative thermophoretic study of disease-related protein aggregates. Scientific Reports. 6: 22829. PMID 26984748 DOI: 10.1038/srep22829  0.52
2016 Pedersen JT, Chen SW, Borg CB, Ness S, Bahl JM, Heegard NH, Dobson CM, Hemmingsen L, Cremades N, Teilum K. Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing. Journal of the American Chemical Society. PMID 26967463 DOI: 10.1021/jacs.5b13577  0.4
2016 Habchi J, Arosio P, Perni M, Costa AR, Yagi-Utsumi M, Joshi P, Chia S, Cohen SI, Müller MB, Linse S, Nollen EA, Dobson CM, Knowles TP, Vendruscolo M. An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease. Science Advances. 2: e1501244. PMID 26933687 DOI: 10.1126/sciadv.1501244  0.96
2016 Cabrita LD, Cassaignau AM, Launay HM, Waudby CA, Wlodarski T, Camilloni C, Karyadi ME, Robertson AL, Wang X, Wentink AS, Goodsell LS, Woolhead CA, Vendruscolo M, Dobson CM, Christodoulou J. A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding. Nature Structural & Molecular Biology. PMID 26926436 DOI: 10.1038/nsmb.3182  0.96
2016 Joshi P, Chia S, Habchi J, Knowles TP, Dobson CM, Vendruscolo M. A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins. Acs Combinatorial Science. PMID 26923286 DOI: 10.1021/acscombsci.5b00129  0.96
2016 Iljina M, Garcia GA, Horrocks MH, Tosatto L, Choi ML, Ganzinger KA, Abramov AY, Gandhi S, Wood NW, Cremades N, Dobson CM, Knowles TP, Klenerman D. Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading. Proceedings of the National Academy of Sciences of the United States of America. PMID 26884195 DOI: 10.1073/pnas.1524128113  0.96
2016 Yates EV, Meisl G, Knowles TP, Dobson CM. An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation. The Journal of Physical Chemistry. B. PMID 26865546 DOI: 10.1021/acs.jpcb.5b09663  0.52
2016 Michaels TC, Cohen SI, Vendruscolo M, Dobson CM, Knowles TP. Hamiltonian Dynamics of Protein Filament Formation. Physical Review Letters. 116: 038101. PMID 26849615 DOI: 10.1103/PhysRevLett.116.038101  0.72
2016 Saar KL, Yates EV, Müller T, Saunier S, Dobson CM, Knowles TP. Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform. Biophysical Journal. 110: 555-560. PMID 26840721 DOI: 10.1016/j.bpj.2015.11.3523  0.6
2016 Cappelli S, Penco A, Mannini B, Cascella R, Wilson M, Ecroyd H, Li X, Buxbaum J, Dobson CM, Cecchi C, Relini A, Chiti F. Effect of molecular chaperones on aberrant protein oligomers in vitro: super- versus sub-stoichiometric chaperone concentrations. Biological Chemistry. PMID 26812789 DOI: 10.1515/hsz-2015-0250  0.68
2016 Horrocks MH, Lee SF, Gandhi S, Magdalinou NK, Chen SW, Devine MJ, Tosatto L, Kjaergaard M, Beckwith JS, Zetterberg H, Iljina M, Cremades N, Dobson CM, Wood NW, Klenerman D. Single-molecule imaging of individual amyloid protein aggregates in human biofluids. Acs Chemical Neuroscience. PMID 26800462 DOI: 10.1021/acschemneuro.5b00324  0.96
2016 Meisl G, Kirkegaard JB, Arosio P, Michaels TC, Vendruscolo M, Dobson CM, Linse S, Knowles TP. Molecular mechanisms of protein aggregation from global fitting of kinetic models. Nature Protocols. 11: 252-72. PMID 26741409 DOI: 10.1038/nprot.2016.010  0.96
2015 Arosio P, Müller T, Rajah L, Yates EV, Aprile FA, Zhang Y, Cohen SI, White DA, Herling TW, de Genst EJ, Linse S, Vendruscolo M, Dobson CM, Knowles TP. Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins Under Native Solution Conditions. Acs Nano. PMID 26678709 DOI: 10.1021/acsnano.5b04713  0.96
2015 Tosatto L, Horrocks MH, Dear AJ, Knowles TP, Dalla Serra M, Cremades N, Dobson CM, Klenerman D. Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants. Scientific Reports. 5: 16696. PMID 26582456 DOI: 10.1038/srep16696  0.96
2015 Deas E, Cremades N, Angelova PR, Ludtmann M, Yao Z, Chen S, Horrocks M, Banushi B, Little D, Devine M, Gissen P, Klenerman D, Dobson C, Wood N, Gandhi S, et al. Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson's disease. Antioxidants & Redox Signaling. PMID 26564470 DOI: 10.1089/ars.2015.6343  0.72
2015 Terol PA, Kumita JR, Hook SC, Dobson CM, Esbjörner EK. Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide. Biochemical and Biophysical Research Communications. PMID 26551456 DOI: 10.1016/j.bbrc.2015.11.018  0.96
2015 Michaels TC, Yde P, Willis JC, Jensen MH, Otzen D, Dobson CM, Buell AK, Knowles TP. The length distribution of frangible biofilaments. The Journal of Chemical Physics. 143: 164901. PMID 26520548 DOI: 10.1063/1.4933230  0.96
2015 Zeineddine R, Pundavela JF, Corcoran L, Stewart EM, Do-Ha D, Bax M, Guillemin G, Vine KL, Hatters DM, Ecroyd H, Dobson CM, Turner BJ, Ooi L, Wilson MR, Cashman NR, et al. SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation. Molecular Neurodegeneration. 10: 57. PMID 26520394 DOI: 10.1186/s13024-015-0053-4  0.96
2015 Pickhardt M, Neumann T, Schwizer D, Callaway K, Vendruscolo M, Schenk D, George-Hyslop PS, Mandelkow EM, Dobson CM, McConlogue L, Mandelkow E, Toth G. Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies. Current Alzheimer Research. 12: 814-28. PMID 26510979  0.96
2015 Newby FN, De Simone A, Yagi-Utsumi M, Salvatella X, Dobson CM, Vendruscolo M. Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins. Biochemistry. PMID 26479087 DOI: 10.1021/acs.biochem.5b00670  0.96
2015 Labrador-Garrido A, Cejudo-Guillén M, Daturpalli S, Leal MM, Klippstein R, De Genst EJ, Villadiego J, Toledo-Aral JJ, Dobson CM, Jackson SE, Pozo D, Roodveldt C. Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the α-synuclein-elicited immune response. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26443817 DOI: 10.1096/fj.15-275131  0.72
2015 Yagi-Utsumi M, Dobson CM. Conformational Effects of the A21G Flemish Mutation on the Aggregation of Amyloid β Peptide. Biological & Pharmaceutical Bulletin. 38: 1668-72. PMID 26424029 DOI: 10.1248/bpb.b15-00466  0.96
2015 Yates EV, Müller T, Rajah L, De Genst EJ, Arosio P, Linse S, Vendruscolo M, Dobson CM, Knowles TP. Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity. Nature Chemistry. 7: 802-9. PMID 26391079 DOI: 10.1038/nchem.2344  0.96
2015 Wright MA, Aprile FA, Arosio P, Vendruscolo M, Dobson CM, Knowles TP. Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates. Chemical Communications (Cambridge, England). 51: 14425-34. PMID 26328629 DOI: 10.1039/c5cc03689e  0.96
2015 Horrocks MH, Tosatto L, Dear AJ, Garcia GA, Iljina M, Cremades N, Dalla Serra M, Knowles TP, Dobson CM, Klenerman D. Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α-Synuclein Oligomers. Analytical Chemistry. 87: 8818-26. PMID 26258431 DOI: 10.1021/acs.analchem.5b01811  0.96
2015 Herling TW, Garcia GA, Michaels TC, Grentz W, Dean J, Shimanovich U, Gang H, Müller T, Kav B, Terentjev EM, Dobson CM, Knowles TP. Force generation by the growth of amyloid aggregates. Proceedings of the National Academy of Sciences of the United States of America. 112: 9524-9. PMID 26195762 DOI: 10.1073/pnas.1417326112  0.52
2015 Wyatt AR, Kumita JR, Farrawell NE, Dobson CM, Wilson MR. Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies. Plos One. 10: e0130036. PMID 26103636 DOI: 10.1371/journal.pone.0130036  0.96
2015 Dworzak J, Renvoisé B, Habchi J, Yates EV, Combadière C, Knowles TP, Dobson CM, Blackstone C, Paulsen O, Murphy PM. Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity. Plos One. 10: e0127730. PMID 26038823 DOI: 10.1371/journal.pone.0127730  0.52
2015 Zhou XM, Shimanovich U, Herling TW, Wu S, Dobson CM, Knowles TP, Perrett S. Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry. Acs Nano. 9: 5772-81. PMID 26030507 DOI: 10.1021/acsnano.5b00061  0.52
2015 Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU. Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell. 161: 919-32. PMID 25957690 DOI: 10.1016/j.cell.2015.03.032  0.96
2015 Chen SW, Drakulic S, Deas E, Ouberai M, Aprile FA, Arranz R, Ness S, Roodveldt C, Guilliams T, De-Genst EJ, Klenerman D, Wood NW, Knowles TP, Alfonso C, Rivas G, ... ... Dobson CM, et al. Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation. Proceedings of the National Academy of Sciences of the United States of America. 112: E1994-2003. PMID 25855634 DOI: 10.1073/pnas.1421204112  0.96
2015 Baldwin AJ, Egan DL, Warren FJ, Barker PD, Dobson CM, Butterworth PJ, Ellis PR. Investigating the mechanisms of amylolysis of starch granules by solution-state NMR. Biomacromolecules. 16: 1614-21. PMID 25815624 DOI: 10.1021/acs.biomac.5b00190  0.96
2015 Cohen SI, Arosio P, Presto J, Kurudenkandy FR, Biverstål H, Dolfe L, Dunning C, Yang X, Frohm B, Vendruscolo M, Johansson J, Dobson CM, Fisahn A, Knowles TP, Linse S. A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Nature Structural & Molecular Biology. 22: 207-13. PMID 25686087 DOI: 10.1038/nsmb.2971  0.96
2015 Galvagnion C, Buell AK, Meisl G, Michaels TC, Vendruscolo M, Knowles TP, Dobson CM. Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation. Nature Chemical Biology. 11: 229-34. PMID 25643172 DOI: 10.1038/nchembio.1750  0.96
2015 Ciryam P, Kundra R, Morimoto RI, Dobson CM, Vendruscolo M. Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases. Trends in Pharmacological Sciences. 36: 72-7. PMID 25636813 DOI: 10.1016/j.tips.2014.12.004  0.96
2015 De Simone A, Aprile FA, Dhulesia A, Dobson CM, Vendruscolo M. Structure of a low-population intermediate state in the release of an enzyme product. Elife. 4. PMID 25575179 DOI: 10.7554/eLife.02777  0.96
2015 Shimanovich U, Efimov I, Mason TO, Flagmeier P, Buell AK, Gedanken A, Linse S, Åkerfeldt KS, Dobson CM, Weitz DA, Knowles TP. Protein microgels from amyloid fibril networks. Acs Nano. 9: 43-51. PMID 25469621 DOI: 10.1021/nn504869d  0.96
2015 Dworzak J, Renvoisé B, Habchi J, Yates EV, Combadière C, Knowles TP, Dobson CM, Blackstone C, Paulsen O, Murphy PM. Neuronal Cx3cr1 deficiency protects against amyloid β-induced neurotoxicity Plos One. 10. DOI: 10.1371/journal.pone.0127730  0.96
2015 Herling TW, Garcia GA, Michaels TCT, Grentz W, Dean J, Shimanovich U, Gang H, Müller T, Kav B, Terentjev EM, Dobson CM, Knowles TPJ. Force generation by the growth of amyloid aggregates Proceedings of the National Academy of Sciences of the United States of America. 112: 9524-9529. DOI: 10.1073/pnas.1417326112  0.96
2015 Knowles TPJ, Vendruscolo M, Dobson CM. The physical basis of protein misfolding disorders Physics Today. 68: 36-41. DOI: 10.1063/PT.3.2719  0.96
2015 Zhou XM, Shimanovich U, Herling TW, Wu S, Dobson CM, Knowles TPJ, Perrett S. Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry Acs Nano. 9: 5772-5781. DOI: 10.1021/acsnano.5b00061  0.96
2015 Pietralik Z, Kumita JR, Dobson CM, Kozak M. The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution Colloids and Surfaces B: Biointerfaces. 131: 83-92. DOI: 10.1016/j.colsurfb.2015.04.042  0.96
2015 Dobson CM. Alzheimer’s disease: addressing a twenty-first century plague Rendiconti Lincei. 26: 251-262. DOI: 10.1007/s12210-015-0453-y  0.96
2014 Labrador-Garrido A, Cejudo-Guillén M, Klippstein R, De Genst EJ, Tomas-Gallardo L, Leal MM, Villadiego J, Toledo-Aral JJ, Dobson CM, Pozo D, Roodveldt C. Chaperoned amyloid proteins for immune manipulation: α-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype. Immunity, Inflammation and Disease. 2: 226-38. PMID 25866630 DOI: 10.1002/iid3.39  0.52
2014 Levin A, Mason TO, Adler-Abramovich L, Buell AK, Meisl G, Galvagnion C, Bram Y, Stratford SA, Dobson CM, Knowles TP, Gazit E. Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers. Nature Communications. 5: 5219. PMID 25391268 DOI: 10.1038/ncomms6219  0.96
2014 Allison JR, Rivers RC, Christodoulou JC, Vendruscolo M, Dobson CM. A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein. Biochemistry. 53: 7170-83. PMID 25389903 DOI: 10.1021/bi5009326  0.96
2014 Ganzinger KA, Narayan P, Qamar SS, Weimann L, Ranasinghe RT, Aguzzi A, Dobson CM, McColl J, St George-Hyslop P, Klenerman D. Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)). Chembiochem : a European Journal of Chemical Biology. 15: 2515-21. PMID 25294384 DOI: 10.1002/cbic.201402377  0.72
2014 Ma?nsson C, Arosio P, Hussein R, Kampinga HH, Hashem RM, Boelens WC, Dobson CM, Knowles TPJ, Linse S, Emanuelsson C. Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation Journal of Biological Chemistry. 289: 31066-31076. PMID 25217638 DOI: 10.1074/jbc.M114.595124  0.72
2014 Buell AK, Dobson CM, Knowles TPJ. The physical chemistry of the amyloid phenomenon: Thermodynamics and kinetics of fi lamentous protein aggregation Essays in Biochemistry. 56: 11-39. PMID 25131584 DOI: 10.1042/BSE0560011  0.96
2014 Mannini B, Mulvihill E, Sgromo C, Cascella R, Khodarahmi R, Ramazzotti M, Dobson CM, Cecchi C, Chiti F. Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity. Acs Chemical Biology. 9: 2309-17. PMID 25079908 DOI: 10.1021/cb500505m  0.68
2014 Meisl G, Yang X, Hellstrand E, Frohm B, Kirkegaard JB, Cohen SIA, Dobson CM, Linse S, Knowles TPJ. Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides Proceedings of the National Academy of Sciences of the United States of America. 111: 9384-9389. PMID 24938782 DOI: 10.1073/pnas.1401564111  0.96
2014 Fusco G, De Simone A, Gopinath T, Vostrikov V, Vendruscolo M, Dobson CM, Veglia G. Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour. Nature Communications. 5: 3827. PMID 24871041 DOI: 10.1038/ncomms4827  0.96
2014 Esbjörner EK, Chan F, Rees E, Erdelyi M, Luheshi LM, Bertoncini CW, Kaminski CF, Dobson CM, Kaminski Schierle GS. Direct observations of amyloid β self-assembly in live cells provide insights into differences in the kinetics of Aβ(1-40) and Aβ(1-42) aggregation. Chemistry & Biology. 21: 732-42. PMID 24856820 DOI: 10.1016/j.chembiol.2014.03.014  0.4
2014 Knowles TP, Vendruscolo M, Dobson CM. The amyloid state and its association with protein misfolding diseases. Nature Reviews. Molecular Cell Biology. 15: 384-96. PMID 24854788 DOI: 10.1038/nrm3810  0.96
2014 Buell AK, Galvagnion C, Gaspar R, Sparr E, Vendruscolo M, Knowles TP, Linse S, Dobson CM. Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America. 111: 7671-6. PMID 24817693 DOI: 10.1073/pnas.1315346111  0.96
2014 Wyatt AR, Kumita JR, Mifsud RW, Gooden CA, Wilson MR, Dobson CM. Hypochlorite-induced structural modifications enhance the chaperone activity of human ?2-macroglobulin Proceedings of the National Academy of Sciences of the United States of America. 111: E2081-E2090. PMID 24799681 DOI: 10.1073/pnas.1403379111  0.96
2014 O'Brien EP, Ciryam P, Vendruscolo M, Dobson CM. Understanding the influence of codon translation rates on cotranslational protein folding. Accounts of Chemical Research. 47: 1536-44. PMID 24784899 DOI: 10.1021/ar5000117  0.96
2014 Garcia GA, Cohen SIA, Dobson CM, Knowles TPJ. Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 89. PMID 24730879 DOI: 10.1103/PhysRevE.89.032712  0.72
2014 Wacker J, Rönicke R, Westermann M, Wulff M, Reymann KG, Dobson CM, Horn U, Crowther DC, Luheshi LM, Fändrich M. Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies. Acta Neuropathologica Communications. 2: 43. PMID 24725347 DOI: 10.1186/2051-5960-2-43  0.72
2014 Narayan P, Holmström KM, Kim DH, Whitcomb DJ, Wilson MR, St George-Hyslop P, Wood NW, Dobson CM, Cho K, Abramov AY, Klenerman D. Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage. Biochemistry. 53: 2442-53. PMID 24717093 DOI: 10.1021/bi401606f  0.96
2014 Cohen SI, Rajah L, Yoon CH, Buell AK, White DA, Sperling RA, Vendruscolo M, Terentjev EM, Dobson CM, Weitz DA, Knowles TP. Spatial propagation of protein polymerization. Physical Review Letters. 112: 098101. PMID 24655282 DOI: 10.1103/PhysRevLett.112.098101  0.96
2014 Dobson CM. Dynamics and timekeeping in biological systems Annual Review of Biochemistry. 83: 159-164. PMID 24606145 DOI: 10.1146/annurev-biochem-013014-102724  0.96
2014 Arosio P, Vendruscolo M, Dobson CM, Knowles TP. Chemical kinetics for drug discovery to combat protein aggregation diseases. Trends in Pharmacological Sciences. 35: 127-35. PMID 24560688 DOI: 10.1016/j.tips.2013.12.005  0.96
2014 Tóth G, Gardai SJ, Zago W, Bertoncini CW, Cremades N, Roy SL, Tambe MA, Rochet JC, Galvagnion C, Skibinski G, Finkbeiner S, Bova M, Regnstrom K, Chiou SS, Johnston J, ... ... Dobson CM, et al. Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. Plos One. 9: e87133. PMID 24551051 DOI: 10.1371/journal.pone.0087133  0.96
2014 Lorenzen N, Nielsen SB, Buell AK, Kaspersen JD, Arosio P, Vad BS, Paslawski W, Christiansen G, Valnickova-Hansen Z, Andreasen M, Enghild JJ, Pedersen JS, Dobson CM, Knowles TPJ, Otzen DE. The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation Journal of the American Chemical Society. 136: 3859-3868. PMID 24527756 DOI: 10.1021/ja411577t  0.72
2014 Abeln S, Vendruscolo M, Dobson CM, Frenkel D. A simple lattice model that captures protein folding, aggregation and amyloid formation. Plos One. 9: e85185. PMID 24454816 DOI: 10.1371/journal.pone.0085185  0.96
2014 O'Brien EP, Vendruscolo M, Dobson CM. Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates. Nature Communications. 5: 2988. PMID 24394622 DOI: 10.1038/ncomms3988  0.72
2014 Pinotsi D, Buell AK, Galvagnion C, Dobson CM, Kaminski Schierle GS, Kaminski CF. Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy Nano Letters. 14: 339-345. PMID 24303845 DOI: 10.1021/nl4041093  0.72
2014 Bolognesi B, Cohen SIA, Aran Terol P, Esbjörner EK, Giorgetti S, Mossuto MF, Natalello A, Brorsson AC, Knowles TPJ, Dobson CM, Luheshi LM. Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ42 peptide Acs Chemical Biology. 9: 378-382. PMID 24199868 DOI: 10.1021/cb400616y  0.96
2014 Mannini B, Mulvihill E, Sgromo C, Cascella R, Khodarahmi R, Ramazzotti M, Dobson CM, Cecchi C, Chiti F. Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity Acs Chemical Biology. 9: 2309-2317. DOI: 10.1021/cb500505m  0.96
2014 De Genst E, Chirgadze DY, Klein FAC, Butler DC, Matak-Vinkovi? D, Trottier Y, Huston JS, Messer A, Dobson CM. Structure of a Single-Chain Fv Bound to the 17 N-Terminal Residues of Huntingtin Provides Insights into Pathogenic Amyloid Formation and Suppression Journal of Molecular Biology. DOI: 10.1016/j.jmb.2015.03.021  0.96
2014 Esbjörner EK, Chan F, Rees E, Erdelyi M, Luheshi LM, Bertoncini CW, Kaminski CF, Dobson CM, Kaminski Schierle GS. Direct observations of amyloid β Self-assembly in live cells provide insights into differences in the kinetics of Aβ(1-40) and Aβ(1-42) aggregation Chemistry and Biology. 21: 732-742. DOI: 10.1016/j.chembiol.2014.03.014  0.72
2014 De Genst E, Messer A, Dobson CM. Antibodies and protein misfolding: From structural research tools to therapeutic strategies Biochimica Et Biophysica Acta - Proteins and Proteomics. 1844: 1907-1919. DOI: 10.1016/j.bbapap.2014.08.016  0.72
2013 Volpatti LR, Vendruscolo M, Dobson CM, Knowles TP. A clear view of polymorphism, twist, and chirality in amyloid fibril formation. Acs Nano. 7: 10443-8. PMID 24359171 DOI: 10.1021/nn406121w  0.96
2013 Debelouchina GT, Bayro MJ, Fitzpatrick AW, Ladizhansky V, Colvin MT, Caporini MA, Jaroniec CP, Bajaj VS, Rosay M, Macphee CE, Vendruscolo M, Maas WE, Dobson CM, Griffin RG. Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy. Journal of the American Chemical Society. 135: 19237-47. PMID 24304221 DOI: 10.1021/ja409050a  0.72
2013 Roodveldt C, Labrador-Garrido A, Gonzalez-Rey E, Lachaud CC, Guilliams T, Fernandez-Montesinos R, Benitez-Rondan A, Robledo G, Hmadcha A, Delgado M, Dobson CM, Pozo D. Preconditioning of microglia by α-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation. Plos One. 8: e79160. PMID 24236103 DOI: 10.1371/journal.pone.0079160  0.72
2013 Ciryam P, Tartaglia GG, Morimoto RI, Dobson CM, Vendruscolo M. Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins. Cell Reports. 5: 781-90. PMID 24183671 DOI: 10.1016/j.celrep.2013.09.043  0.96
2013 Waudby CA, Camilloni C, Fitzpatrick AW, Cabrita LD, Dobson CM, Vendruscolo M, Christodoulou J. In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells. Plos One. 8: e72286. PMID 23991082 DOI: 10.1371/journal.pone.0072286  0.72
2013 De Simone A, Montalvao RW, Dobson CM, Vendruscolo M. Characterization of the interdomain motions in hen lysozyme using residual dipolar couplings as replica-averaged structural restraints in molecular dynamics simulations. Biochemistry. 52: 6480-6. PMID 23941501 DOI: 10.1021/bi4007513  0.72
2013 De Genst E, Chan PH, Pardon E, Hsu ST, Kumita JR, Christodoulou J, Menzer L, Chirgadze DY, Robinson CV, Muyldermans S, Matagne A, Wyns L, Dobson CM, Dumoulin M. A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation. The Journal of Physical Chemistry. B. 117: 13245-58. PMID 23919586 DOI: 10.1021/jp403425z  0.96
2013 Zhu M, De Simone A, Schenk D, Toth G, Dobson CM, Vendruscolo M. Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide. The Journal of Chemical Physics. 139: 035101. PMID 23883055 DOI: 10.1063/1.4811831  0.96
2013 Aprile FA, Dhulesia A, Stengel F, Roodveldt C, Benesch JL, Tortora P, Robinson CV, Salvatella X, Dobson CM, Cremades N. Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain. Plos One. 8: e67961. PMID 23840795 DOI: 10.1371/journal.pone.0067961  0.96
2013 Ouberai MM, Wang J, Swann MJ, Galvagnion C, Guilliams T, Dobson CM, Welland ME. α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling Journal of Biological Chemistry. 288: 20883-20895. PMID 23740253 DOI: 10.1074/jbc.M113.478297  0.72
2013 Cohen SI, Linse S, Luheshi LM, Hellstrand E, White DA, Rajah L, Otzen DE, Vendruscolo M, Dobson CM, Knowles TP. Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism. Proceedings of the National Academy of Sciences of the United States of America. 110: 9758-63. PMID 23703910 DOI: 10.1073/pnas.1218402110  0.96
2013 Pinotsi D, Buell AK, Dobson CM, Kaminski Schierle GS, Kaminski CF. A Label-Free, Quantitative Assay of Amyloid Fibril Growth Based on Intrinsic Fluorescence Chembiochem. 14: 846-850. PMID 23592254 DOI: 10.1002/cbic.201300103  0.72
2013 Guilliams T, El-Turk F, Buell AK, O'Day EM, Aprile FA, Esbjörner EK, Vendruscolo M, Cremades N, Pardon E, Wyns L, Welland ME, Steyaert J, Christodoulou J, Dobson CM, De Genst E. Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages. Journal of Molecular Biology. 425: 2397-411. PMID 23557833 DOI: 10.1016/j.jmb.2013.01.040  0.96
2013 Xu LQ, Wu S, Buell AK, Cohen SI, Chen LJ, Hu WH, Cusack SA, Itzhaki LS, Zhang H, Knowles TP, Dobson CM, Welland ME, Jones GW, Perrett S. Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20110410. PMID 23530260 DOI: 10.1098/rstb.2011.0410  0.96
2013 Fitzpatrick AW, Debelouchina GT, Bayro MJ, Clare DK, Caporini MA, Bajaj VS, Jaroniec CP, Wang L, Ladizhansky V, Müller SA, MacPhee CE, Waudby CA, Mott HR, De Simone A, Knowles TP, ... ... Dobson CM, et al. Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proceedings of the National Academy of Sciences of the United States of America. 110: 5468-73. PMID 23513222 DOI: 10.1073/pnas.1219476110  0.96
2013 Vendruscolo M, Dobson CM. Structural biology: Protein self-assembly intermediates. Nature Chemical Biology. 9: 216-7. PMID 23508184 DOI: 10.1038/nchembio.1210  0.96
2013 Buell AK, Hung P, Salvatella X, Welland ME, Dobson CM, Knowles TPJ. Electrostatic effects in filamentous protein aggregation Biophysical Journal. 104: 1116-1126. PMID 23473495 DOI: 10.1016/j.bpj.2013.01.031  0.96
2013 Chan FTS, Kaminski Schierle GS, Kumita JR, Bertoncini CW, Dobson CM, Kaminski CF. Protein amyloids develop an intrinsic fluorescence signature during aggregation Analyst. 138: 2156-2162. PMID 23420088 DOI: 10.1039/c3an36798c  0.56
2013 Wyatt AR, Const P, Ecroyd H, Dobson CM, Wilson MR, Kumita JR, Yerbury JJ. Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms Febs Letters. 587: 398-403. PMID 23353684 DOI: 10.1016/j.febslet.2013.01.020  0.96
2013 Narayan P, Ganzinger KA, McColl J, Weimann L, Meehan S, Qamar S, Carver JA, Wilson MR, St George-Hyslop P, Dobson CM, Klenerman D. Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells. Journal of the American Chemical Society. 135: 1491-8. PMID 23339742 DOI: 10.1021/ja3103567  0.96
2013 Ciryam P, Morimoto RI, Vendruscolo M, Dobson CM, O'Brien EP. In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome. Proceedings of the National Academy of Sciences of the United States of America. 110: E132-40. PMID 23256155 DOI: 10.1073/pnas.1213624110  0.72
2013 Lancaster DL, Dobson CM, Rachubinski RA. Chaperone proteins select and maintain [PIN+] prion conformations in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 288: 1266-76. PMID 23148221 DOI: 10.1074/jbc.M112.377564  0.44
2013 Cohen SIA, Vendruscolo M, Dobson CM, Knowles TPJ. The Kinetics and Mechanisms of Amyloid Formation Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties. 183-209. DOI: 10.1002/9783527654185.ch10  0.72
2013 Dobson CM. The Amyloid Phenomenon and Its Significance Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties. 1-19. DOI: 10.1002/9783527654185.ch1  0.96
2012 Ahn M, de Genst E, Kaminski Schierle GS, Erdelyi M, Kaminski CF, Dobson CM, Kumita JR. Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme Plos One. 7. PMID 23166837 DOI: 10.1371/journal.pone.0050192  0.56
2012 Narayan P, Meehan S, Carver JA, Wilson MR, Dobson CM, Klenerman D. Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones Biochemistry. 51: 9270-9276. PMID 23106396 DOI: 10.1021/bi301277k  0.96
2012 Knowles TP, De Simone A, Fitzpatrick AW, Baldwin A, Meehan S, Rajah L, Vendruscolo M, Welland ME, Dobson CM, Terentjev EM. Twisting transition between crystalline and fibrillar phases of aggregated peptides. Physical Review Letters. 109: 158101. PMID 23102370  0.96
2012 Roodveldt C, Andersson A, De Genst EJ, Labrador-Garrido A, Buell AK, Dobson CM, Tartaglia GG, Vendruscolo M. A rationally designed six-residue swap generates comparability in the aggregation behavior of α-synuclein and β-synuclein. Biochemistry. 51: 8771-8. PMID 23003198 DOI: 10.1021/bi300558q  0.96
2012 De Genst E, Dobson CM. Nanobodies as structural probes of protein misfolding and fibril formation. Methods in Molecular Biology (Clifton, N.J.). 911: 533-558. PMID 22886275 DOI: 10.1007/978-1-61779-968-6_34  0.96
2012 Lorenzen N, Cohen SIA, Nielsen SB, Herling TW, Christiansen G, Dobson CM, Knowles TPJ, Otzen D. Role of elongation and secondary pathways in S6 amyloid fibril growth Biophysical Journal. 102: 2167-2175. PMID 22824281 DOI: 10.1016/j.bpj.2012.03.047  0.72
2012 Mannini B, Cascella R, Zampagni M, Van Waarde-Verhagen M, Meehan S, Roodveldt C, Campioni S, Boninsegna M, Penco A, Relini A, Kampinga HH, Dobson CM, Wilson MR, Cecchi C, Chiti F. Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers Proceedings of the National Academy of Sciences of the United States of America. 109: 12479-12484. PMID 22802614 DOI: 10.1073/pnas.1117799109  0.72
2012 Bemporad F, De Simone A, Chiti F, Dobson CM. Characterizing intermolecular interactions that initiate native-like protein aggregation. Biophysical Journal. 102: 2595-604. PMID 22713575 DOI: 10.1016/j.bpj.2012.03.057  0.96
2012 Waudby CA, Mantle MD, Cabrita LD, Gladden LF, Dobson CM, Christodoulou J. Rapid distinction of intracellular and extracellular proteins using NMR diffusion measurements Journal of the American Chemical Society. 134: 11312-11315. PMID 22694283 DOI: 10.1021/ja304912c  0.72
2012 O'Brien EP, Christodoulou J, Vendruscolo M, Dobson CM. Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions. Journal of the American Chemical Society. 134: 10920-32. PMID 22680285 DOI: 10.1021/ja302305u  0.96
2012 O'Brien EP, Vendruscolo M, Dobson CM. Prediction of variable translation rate effects on cotranslational protein folding. Nature Communications. 3: 868. PMID 22643895 DOI: 10.1038/ncomms1850  0.96
2012 Cremades N, Cohen SI, Deas E, Abramov AY, Chen AY, Orte A, Sandal M, Clarke RW, Dunne P, Aprile FA, Bertoncini CW, Wood NW, Knowles TP, Dobson CM, Klenerman D. Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell. 149: 1048-59. PMID 22632969 DOI: 10.1016/j.cell.2012.03.037  0.96
2012 McGuire EK, Motskin M, Bolognesi B, Bergin SD, Knowles TPJ, Skepper J, Luheshi LM, McComb DW, Dobson CM, Porter AE. Selenium-enhanced electron microscopic imaging of different aggregate forms of a segment of the amyloid β peptide in cells Acs Nano. 6: 4740-4747. PMID 22631869 DOI: 10.1021/nn204859e  0.96
2012 Buell AK, Dobson CM, Welland ME. Measuring the kinetics of amyloid fibril elongation using quartz crystal microbalances Methods in Molecular Biology. 849: 101-119. PMID 22528086 DOI: 10.1007/978-1-61779-551-0_8  0.96
2012 De Simone A, Kitchen C, Kwan AH, Sunde M, Dobson CM, Frenkel D. Intrinsic disorder modulates protein self-assembly and aggregation. Proceedings of the National Academy of Sciences of the United States of America. 109: 6951-6. PMID 22509003 DOI: 10.1073/pnas.1118048109  0.72
2012 Buell AK, Dhulesia A, White DA, Knowles TP, Dobson CM, Welland ME. Detailed analysis of the energy barriers for amyloid fibril growth. Angewandte Chemie (International Ed. in English). 51: 5247-51. PMID 22489083 DOI: 10.1002/anie.201108040  0.96
2012 Speretta E, Jahn TR, Tartaglia GG, Favrin G, Barros TP, Imarisio S, Lomas DA, Luheshi LM, Crowther DC, Dobson CM. Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity. The Journal of Biological Chemistry. 287: 20748-54. PMID 22461632 DOI: 10.1074/jbc.M112.350124  0.96
2012 Cohen SI, Vendruscolo M, Dobson CM, Knowles TP. From macroscopic measurements to microscopic mechanisms of protein aggregation. Journal of Molecular Biology. 421: 160-71. PMID 22406275 DOI: 10.1016/j.jmb.2012.02.031  0.72
2012 Gregory JM, Barros TP, Meehan S, Dobson CM, Luheshi LM. The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila. Plos One. 7: e31899. PMID 22384095 DOI: 10.1371/journal.pone.0031899  0.44
2012 Evangelisti E, Cecchi C, Cascella R, Sgromo C, Becatti M, Dobson CM, Chiti F, Stefani M. Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers Journal of Cell Science. 125: 2416-2427. PMID 22344258 DOI: 10.1242/jcs.098434  0.72
2012 Narayan P, Orte A, Clarke RW, Bolognesi B, Hook S, Ganzinger KA, Meehan S, Wilson MR, Dobson CM, Klenerman D. The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β 1-40 peptide Nature Structural and Molecular Biology. 19: 79-84. PMID 22179788 DOI: 10.1038/nsmb.2191  0.96
2012 Abelein A, Bolognesi B, Dobson CM, Gräslund A, Lendel C. Hydrophobicity and conformational change as mechanistic determinants for nonspecific modulators of amyloid β self-assembly Biochemistry. 51: 126-137. PMID 22133042 DOI: 10.1021/bi201745g  0.72
2012 Kumita JR, Helmfors L, Williams J, Luheshi LM, Menzer L, Dumoulin M, Lomas DA, Crowther DC, Dobson CM, Brorsson AC. Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 192-202. PMID 21965601 DOI: 10.1096/fj.11-185983  0.56
2012 Fusco G, De Simone A, Hsu ST, Bemporad F, Vendruscolo M, Chiti F, Dobson CM. ¹H, ¹³C and ¹⁵N resonance assignments of human muscle acylphosphatase. Biomolecular Nmr Assignments. 6: 27-9. PMID 21643968 DOI: 10.1007/s12104-011-9318-1  0.96
2012 Gregory JM, Barros TP, Meehan S, Dobson CM, Luheshi LM. The aggregation and neurotoxicity of TDP-43 and its als-associated 25 kDa fragment are differentially affected by molecular chaperones in drosophila Plos One. 7. DOI: 10.1371/journal.pone.0031899  0.72
2012 Knowles TPJ, De Simone A, Fitzpatrick AW, Baldwin A, Meehan S, Rajah L, Vendruscolo M, Welland ME, Dobson CM, Terentjev EM. Twisting transition between crystalline and fibrillar phases of aggregated peptides Physical Review Letters. 109. DOI: 10.1103/PhysRevLett.109.158101  0.72
2011 De Simone A, Dhulesia A, Soldi G, Vendruscolo M, Hsu ST, Chiti F, Dobson CM. Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility. Proceedings of the National Academy of Sciences of the United States of America. 108: 21057-62. PMID 22160682 DOI: 10.1073/pnas.1112197108  0.96
2011 Fitzpatrick AW, Knowles TP, Waudby CA, Vendruscolo M, Dobson CM. Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation. Plos Computational Biology. 7: e1002169. PMID 22022239 DOI: 10.1371/journal.pcbi.1002169  0.96
2011 Cohen SI, Vendruscolo M, Dobson CM, Knowles TP. Nucleated polymerisation in the presence of pre-formed seed filaments. International Journal of Molecular Sciences. 12: 5844-52. PMID 22016630 DOI: 10.3390/ijms12095844  0.96
2011 Buell AK, Esbjörner EK, Riss PJ, White DA, Aigbirhio FI, Toth G, Welland ME, Dobson CM, Knowles TP. Probing small molecule binding to amyloid fibrils. Physical Chemistry Chemical Physics : Pccp. 13: 20044-52. PMID 22006124 DOI: 10.1039/c1cp22283j  0.72
2011 Shammas SL, Waudby CA, Wang S, Buell AK, Knowles TP, Ecroyd H, Welland ME, Carver JA, Dobson CM, Meehan S. Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation. Biophysical Journal. 101: 1681-9. PMID 21961594 DOI: 10.1016/j.bpj.2011.07.056  0.72
2011 Knowles TP, White DA, Abate AR, Agresti JJ, Cohen SI, Sperling RA, De Genst EJ, Dobson CM, Weitz DA. Observation of spatial propagation of amyloid assembly from single nuclei. Proceedings of the National Academy of Sciences of the United States of America. 108: 14746-51. PMID 21876182 DOI: 10.1073/pnas.1105555108  0.96
2011 Cohen SI, Vendruscolo M, Dobson CM, Knowles TP. Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations. The Journal of Chemical Physics. 135: 065107. PMID 21842956 DOI: 10.1063/1.3608918  0.72
2011 Cohen SI, Vendruscolo M, Dobson CM, Knowles TP. Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations. The Journal of Chemical Physics. 135: 065106. PMID 21842955 DOI: 10.1063/1.3608917  0.96
2011 Cohen SI, Vendruscolo M, Welland ME, Dobson CM, Terentjev EM, Knowles TP. Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments. The Journal of Chemical Physics. 135: 065105. PMID 21842954 DOI: 10.1063/1.3608916  0.96
2011 Vendruscolo M, Knowles TP, Dobson CM. Protein solubility and protein homeostasis: a generic view of protein misfolding disorders. Cold Spring Harbor Perspectives in Biology. 3. PMID 21825020 DOI: 10.1101/cshperspect.a010454  0.96
2011 Whyteside G, Alcocer MJ, Kumita JR, Dobson CM, Lazarou M, Pleass RJ, Archer DB. Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris. Plos One. 6: e22692. PMID 21818368 DOI: 10.1371/journal.pone.0022692  0.96
2011 Kaminski Schierle GS, Van De Linde S, Erdelyi M, Esbjörner EK, Klein T, Rees E, Bertoncini CW, Dobson CM, Sauer M, Kaminski CF. In situ measurements of the formation and morphology of intracellular β-amyloid fibrils by super-resolution fluorescence imaging Journal of the American Chemical Society. 133: 12902-12905. PMID 21793568 DOI: 10.1021/ja201651w  0.72
2011 Bayro MJ, Debelouchina GT, Eddy MT, Birkett NR, MacPhee CE, Rosay M, Maas WE, Dobson CM, Griffin RG. Intermolecular structure determination of amyloid fibrils with magic-angle spinning and dynamic nuclear polarization NMR. Journal of the American Chemical Society. 133: 13967-74. PMID 21774549 DOI: 10.1021/ja203756x  0.56
2011 Knowles TPJ, Devlin GL, Dobson CM, Welland ME. Probing protein aggregation with quartz crystal microbalances Methods in Molecular Biology. 752: 137-145. PMID 21713635 DOI: 10.1007/978-1-60327-223-0_9  0.56
2011 Cabrita LD, Waudby CA, Dobson CM, Christodoulou J. Solution-state nuclear magnetic resonance spectroscopy and protein folding Methods in Molecular Biology. 752: 97-120. PMID 21713633 DOI: 10.1007/978-1-60327-223-0_7  0.96
2011 Kohlhoff KJ, Jahn TR, Lomas DA, Dobson CM, Crowther DC, Vendruscolo M. The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 755-60. PMID 21698336 DOI: 10.1039/c0ib00149j  0.72
2011 Levitan K, Chereau D, Cohen SIA, Knowles TPJ, Dobson CM, Fink AL, Anderson JP, Goldstein JM, Millhauser GL. Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein Journal of Molecular Biology. 411: 329-333. PMID 21689664 DOI: 10.1016/j.jmb.2011.05.046  0.72
2011 Mossuto MF, Bolognesi B, Guixer B, Dhulesia A, Agostini F, Kumita JR, Tartaglia GG, Dumoulin M, Dobson CM, Salvatella X. Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein. Angewandte Chemie (International Ed. in English). 50: 7048-51. PMID 21671315 DOI: 10.1002/anie.201100986  0.72
2011 Baldwin AJ, Knowles TP, Tartaglia GG, Fitzpatrick AW, Devlin GL, Shammas SL, Waudby CA, Mossuto MF, Meehan S, Gras SL, Christodoulou J, Anthony-Cahill SJ, Barker PD, Vendruscolo M, Dobson CM. Metastability of native proteins and the phenomenon of amyloid formation. Journal of the American Chemical Society. 133: 14160-3. PMID 21650202 DOI: 10.1021/ja2017703  0.96
2011 Shammas SL, Knowles TPJ, Baldwin AJ, MacPhee CE, Welland ME, Dobson CM, Devlin GL. Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions Biophysical Journal. 100: 2783-2791. PMID 21641324 DOI: 10.1016/j.bpj.2011.04.039  0.96
2011 Buell AK, Dhulesia A, Mossuto MF, Cremades N, Kumita JR, Dumoulin M, Welland ME, Knowles TP, Salvatella X, Dobson CM. Population of nonnative states of lysozyme variants drives amyloid fibril formation. Journal of the American Chemical Society. 133: 7737-43. PMID 21528861 DOI: 10.1021/ja109620d  0.96
2011 Wyatt AR, Yerbury JJ, Berghofer P, Greguric I, Katsifis A, Dobson CM, Wilson MR. Clusterin facilitates in vivo clearance of extracellular misfolded proteins Cellular and Molecular Life Sciences. 68: 3919-3931. PMID 21505792 DOI: 10.1007/s00018-011-0684-8  0.72
2011 Kamatari YO, Smith LJ, Dobson CM, Akasaka K. Cavity hydration as a gateway to unfolding: An NMR study of hen lysozyme at high pressure and low temperature Biophysical Chemistry. 156: 24-30. PMID 21367514 DOI: 10.1016/j.bpc.2011.01.009  0.76
2011 Jahn TR, Kohlhoff KJ, Scott M, Tartaglia GG, Lomas DA, Dobson CM, Vendruscolo M, Crowther DC. Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease. Journal of Neuroscience Methods. 197: 186-9. PMID 21315762 DOI: 10.1016/j.jneumeth.2011.01.026  0.96
2011 Kaminski Schierle GS, Bertoncini CW, Chan FT, van der Goot AT, Schwedler S, Skepper J, Schlachter S, van Ham T, Esposito A, Kumita JR, Nollen EA, Dobson CM, Kaminski CF. A FRET sensor for non-invasive imaging of amyloid formation in vivo. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 12: 673-80. PMID 21308945 DOI: 10.1002/cphc.201000996  0.96
2011 Raimondi S, Guglielmi F, Giorgetti S, Di Gaetano S, Arciello A, Monti DM, Relini A, Nichino D, Doglia SM, Natalello A, Pucci P, Mangione P, Obici L, Merlini G, Stoppini M, ... ... Dobson CM, et al. Effects of the known pathogenic mutations on the aggregation pathway of the amyloidogenic peptide of apolipoprotein A-I. Journal of Molecular Biology. 407: 465-76. PMID 21296086 DOI: 10.1016/j.jmb.2011.01.044  0.72
2011 Vendruscolo M, Dobson CM. Protein dynamics: Moore's law in molecular biology. Current Biology : Cb. 21: R68-70. PMID 21256436 DOI: 10.1016/j.cub.2010.11.062  0.96
2011 Wang YQ, Buell AK, Wang XY, Welland ME, Dobson CM, Knowles TPJ, Perrett S. Relationship between prion propensity and the rates of individual molecular steps of fibril assembly Journal of Biological Chemistry. 286: 12101-12107. PMID 21233211 DOI: 10.1074/jbc.M110.208934  0.72
2011 O'Brien EP, Christodoulou J, Vendruscolo M, Dobson CM. New scenarios of protein folding can occur on the ribosome Journal of the American Chemical Society. 133: 513-526. PMID 21204555 DOI: 10.1021/ja107863z  0.96
2010 Buell AK, Dobson CM, Knowles TPJ, Welland ME. Interactions between Amyloidophilic dyes and their relevance to studies of amyloid inhibitors Biophysical Journal. 99: 3492-3497. PMID 21081099 DOI: 10.1016/j.bpj.2010.08.074  0.72
2010 O'Brien EP, Hsu STD, Christodoulou J, Vendruscolo M, Dobson CM. Transient tertiary structure formation within the ribosome exit port Journal of the American Chemical Society. 132: 16928-16937. PMID 21062068 DOI: 10.1021/ja106530y  0.96
2010 Roodveldt C, Labrador-Garrido A, Gonzalez-Rey E, Fernandez-Montesinos R, Caro M, Lachaud CC, Waudby CA, Delgado M, Dobson CM, Pozo D. Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: Differences between wild-type and Parkinson's disease-linked mutants Plos One. 5. PMID 21048992 DOI: 10.1371/journal.pone.0013481  0.96
2010 Dhulesia A, Cremades N, Kumita JR, Hsu ST, Mossuto MF, Dumoulin M, Nietlispach D, Akke M, Salvatella X, Dobson CM. Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution. Journal of the American Chemical Society. 132: 15580-8. PMID 20958028 DOI: 10.1021/ja103524m  0.96
2010 Caporini MA, Bajaj VS, Veshtort M, Fitzpatrick A, MacPhee CE, Vendruscolo M, Dobson CM, Griffin RG. Accurate determination of interstrand distances and alignment in amyloid fibrils by magic angle spinning NMR. The Journal of Physical Chemistry. B. 114: 13555-61. PMID 20925357 DOI: 10.1021/jp106675h  0.72
2010 Buell AK, Blundell JR, Dobson CM, Welland ME, Terentjev EM, Knowles TP. Frequency factors in a landscape model of filamentous protein aggregation. Physical Review Letters. 104: 228101. PMID 20873942 DOI: 10.1103/PhysRevLett.104.228101  0.72
2010 Sandberg A, Luheshi LM, Söllvander S, Pereira de Barros T, Macao B, Knowles TP, BiverstÃ¥l H, Lendel C, Ekholm-Petterson F, Dubnovitsky A, Lannfelt L, Dobson CM, Härd T. Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering. Proceedings of the National Academy of Sciences of the United States of America. 107: 15595-600. PMID 20713699 DOI: 10.1073/pnas.1001740107  0.72
2010 Bayro MJ, Maly T, Birkett NR, Macphee CE, Dobson CM, Griffin RG. High-resolution MAS NMR analysis of PI3-SH3 amyloid fibrils: backbone conformation and implications for protofilament assembly and structure . Biochemistry. 49: 7474-84. PMID 20707313 DOI: 10.1021/bi100864t  0.56
2010 Buell AK, White DA, Meier C, Welland ME, Knowles TP, Dobson CM. Surface attachment of protein fibrils via covalent modification strategies. The Journal of Physical Chemistry. B. 114: 10925-38. PMID 20695458 DOI: 10.1021/jp101579n  0.96
2010 Mossuto MF, Dhulesia A, Devlin G, Frare E, Kumita JR, de Laureto PP, Dumoulin M, Fontana A, Dobson CM, Salvatella X. The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity. Journal of Molecular Biology. 402: 783-96. PMID 20624399 DOI: 10.1016/j.jmb.2010.07.005  0.96
2010 De Genst EJ, Guilliams T, Wellens J, O'Day EM, Waudby CA, Meehan S, Dumoulin M, Hsu ST, Cremades N, Verschueren KH, Pardon E, Wyns L, Steyaert J, Christodoulou J, Dobson CM. Structure and properties of a complex of α-synuclein and a single-domain camelid antibody. Journal of Molecular Biology. 402: 326-43. PMID 20620148 DOI: 10.1016/j.jmb.2010.07.001  0.96
2010 Carulla N, Zhou M, Giralt E, Robinson CV, Dobson CM. Structure and intermolecular dynamics of aggregates populated during amyloid fibril formation studied by hydrogen/deuterium exchange Accounts of Chemical Research. 43: 1072-1079. PMID 20557067 DOI: 10.1021/ar9002784  0.96
2010 Bolognesi B, Kumita JR, Barros TP, Esbjorner EK, Luheshi LM, Crowther DC, Wilson MR, Dobson CM, Favrin G, Yerbury JJ. ANS binding reveals common features of cytotoxic amyloid species. Acs Chemical Biology. 5: 735-40. PMID 20550130 DOI: 10.1021/cb1001203  0.96
2010 Tartaglia GG, Dobson CM, Hartl FU, Vendruscolo M. Physicochemical determinants of chaperone requirements. Journal of Molecular Biology. 400: 579-88. PMID 20416322 DOI: 10.1016/j.jmb.2010.03.066  0.96
2010 Brorsson AC, Bolognesi B, Tartaglia GG, Shammas SL, Favrin G, Watson I, Lomas DA, Chiti F, Vendruscolo M, Dobson CM, Crowther DC, Luheshi LM. Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide. Biophysical Journal. 98: 1677-84. PMID 20409489 DOI: 10.1016/j.bpj.2009.12.4320  0.56
2010 Hagan CL, Johnson RJ, Dhulesia A, Dumoulin M, Dumont J, De Genst E, Christodoulou J, Robinson CV, Dobson CM, Kumita JR. A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis. Protein Engineering, Design & Selection : Peds. 23: 499-506. PMID 20382744 DOI: 10.1093/protein/gzq023  0.96
2010 White DA, Buell AK, Knowles TP, Welland ME, Dobson CM. Protein aggregation in crowded environments. Journal of the American Chemical Society. 132: 5170-5. PMID 20334356 DOI: 10.1021/ja909997e  0.96
2010 Luheshi LM, Hoyer W, de Barros TP, van Dijk Härd I, Brorsson AC, Macao B, Persson C, Crowther DC, Lomas DA, Ståhl S, Dobson CM, Härd T. Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo. Plos Biology. 8: e1000334. PMID 20305716 DOI: 10.1371/journal.pbio.1000334  0.96
2010 Waudby CA, Knowles TP, Devlin GL, Skepper JN, Ecroyd H, Carver JA, Welland ME, Christodoulou J, Dobson CM, Meehan S. The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation. Biophysical Journal. 98: 843-51. PMID 20197038 DOI: 10.1016/j.bpj.2009.10.056  0.96
2010 Cabrita LD, Dobson CM, Christodoulou J. Protein folding on the ribosome Current Opinion in Structural Biology. 20: 33-45. PMID 20149635 DOI: 10.1016/j.sbi.2010.01.005  0.96
2010 Campioni S, Mannini B, Zampagni M, Pensalfini A, Parrini C, Evangelisti E, Relini A, Stefani M, Dobson CM, Cecchi C, Chiti F. A causative link between the structure of aberrant protein oligomers and their toxicity Nature Chemical Biology. 6: 140-147. PMID 20081829 DOI: 10.1038/nchembio.283  0.76
2010 Lendel C, Bolognesi B, Wahlström A, Dobson CM, Gräslund A. Detergent-like interaction of congo red with the amyloid β peptide Biochemistry. 49: 1358-1360. PMID 20070125 DOI: 10.1021/bi902005t  0.96
2010 Brorsson AC, Kumita JR, MacLeod I, Bolognesi B, Speretta E, Luheshi LM, Knowles TP, Dobson CM, Crowther DC. Methods and models in neurodegenerative and systemic protein aggregation diseases. Frontiers in Bioscience (Landmark Edition). 15: 373-96. PMID 20036826 DOI: 10.2741/3626  0.72
2010 Hsu STD, Blaser G, Behrens C, Cabrita LD, Dobson CM, Jackson SE. Folding study of venus reveals a strong ion dependence of its yellow fluorescence under mildly acidic conditions Journal of Biological Chemistry. 285: 4859-4869. PMID 19901033 DOI: 10.1074/jbc.M109.000695  0.72
2010 van Ham TJ, Esposito A, Kumita JR, Hsu ST, Kaminski Schierle GS, Kaminski CF, Dobson CM, Nollen EA, Bertoncini CW. Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation. Journal of Molecular Biology. 395: 627-42. PMID 19891973 DOI: 10.1016/j.jmb.2009.10.066  0.72
2010 McGuire EK, Motskin M, Knowles TPJ, Dobson CM, McComb DW, Porter AE. Imaging Alzheimer's disease-related protein aggregates in human cells using a selenium label Journal of Physics: Conference Series. 241. DOI: 10.1088/1742-6596/241/1/012020  0.72
2010 Cabrita LD, Dobson CM, Christodoulou J. Early nascent chain folding events on the ribosome Israel Journal of Chemistry. 50: 99-108. DOI: 10.1002/ijch.201000015  0.96
2010 White DA, Dobson CM, Welland ME, Knowles TPJ. Quantitative approaches for characterising fibrillar protein nanostructures Materials Research Society Symposium Proceedings. 1274: 33-39.  0.72
2009 Vendruscolo M, Dobson CM. Quantitative approaches to defining normal and aberrant protein homeostasis Faraday Discussions. 143: 277-291. PMID 20334107 DOI: 10.1039/b905825g  0.96
2009 Allison JR, Varnai P, Dobson CM, Vendruscolo M. Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements. Journal of the American Chemical Society. 131: 18314-26. PMID 20028147 DOI: 10.1021/ja904716h  0.56
2009 Cabrita LD, Hsu STD, Launay H, Dobson CM, Christodoulou J. Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy Proceedings of the National Academy of Sciences of the United States of America. 106: 22239-22244. PMID 20018739 DOI: 10.1073/pnas.0903750106  0.96
2009 Knowles TPJ, Waudby CA, Devlin GL, Cohen SIA, Aguzzi A, Vendruscolo M, Terentjev EM, Welland ME, Dobson CM. An analytical solution to the kinetics of breakable filament assembly Science. 326: 1533-1537. PMID 20007899 DOI: 10.1126/science.1178250  0.96
2009 Poon S, Birkett NR, Fowler SB, Luisi BF, Dobson CM, Zurdo J. Amyloidogenicity and aggregate cytotoxicity of human glucagon-like peptide-1 (hGLP-1) Protein and Peptide Letters. 16: 1548-1556. PMID 20001917 DOI: 10.2174/092986609789839232  0.68
2009 Bui JM, Gsponer J, Vendruscolo M, Dobson CM. Analysis of sub-tauc and supra-tauc motions in protein Gbeta1 using molecular dynamics simulations. Biophysical Journal. 97: 2513-20. PMID 19883594 DOI: 10.1016/j.bpj.2009.07.061  0.96
2009 Roodveldt C, Bertoncini CW, Andersson A, Van Der Goot AT, Hsu ST, Fernández-Montesinos R, De Jong J, Van Ham TJ, Nollen EA, Pozo D, Christodoulou J, Dobson CM. Chaperone proteostasis in Parkinson's disease: Stabilization of the Hsp70/α-synuclein complex by Hip Embo Journal. 28: 3758-3770. PMID 19875982 DOI: 10.1038/emboj.2009.298  0.72
2009 Vuchelen A, O'Day E, De Genst E, Pardon E, Wyns L, Dumoulin M, Dobson CM, Christodoulou J, Hsu ST. (1)H, (13)C and (15)N assignments of a camelid nanobody directed against human alpha-synuclein. Biomolecular Nmr Assignments. 3: 231-3. PMID 19763886 DOI: 10.1007/s12104-009-9182-4  0.56
2009 Lendel C, Bertoncini CW, Cremades N, Waudby CA, Vendruscolo M, Dobson CM, Schenk D, Christodoulou J, Toth G. On the mechanism of nonspecific inhibitors of protein aggregation: Dissecting the interactions of α-synuclein with congo red and lacmoid Biochemistry. 48: 8322-8334. PMID 19645507 DOI: 10.1021/bi901285x  0.96
2009 Hsu STD, Behrens C, Cabrita LD, Dobson CM. 1H, 15N and 13C assignments of yellow fluorescent protein (YFP) Venus Biomolecular Nmr Assignments. 3: 67-72. PMID 19636949 DOI: 10.1007/s12104-009-9143-y  0.72
2009 Hsu STD, Cabrita LD, Christodoulou J, Dobson CM. 1H, 15N and 13C assignments of domain 5 of Dictyostelium discoideum gelation factor (ABP-120) in its native and 8M urea-denatured states Biomolecular Nmr Assignments. 3: 29-31. PMID 19636940 DOI: 10.1007/s12104-008-9134-4  0.72
2009 Hsu STD, Dobson CM. 1H, 15N and 13C assignments of the dimeric ribosome binding domain of trigger factor from Escherichia coli Biomolecular Nmr Assignments. 3: 17-20. PMID 19636937 DOI: 10.1007/s12104-008-9130-8  0.72
2009 Porter AE, Knowles TPJ, Muller K, Meehan S, McGuire E, Skepper J, Welland ME, Dobson CM. Imaging Amyloid Fibrils within Cells Using a Se-Labelling Strategy Journal of Molecular Biology. 392: 868-871. PMID 19635483 DOI: 10.1016/j.jmb.2009.07.061  0.96
2009 Bayro MJ, Maly T, Birkett NR, Dobson CM, Griffin RG. Long-range correlations between aliphatic 13C nuclei in protein MAS NMR spectroscopy. Angewandte Chemie (International Ed. in English). 48: 5708-10. PMID 19562810 DOI: 10.1002/anie.200901520  0.68
2009 Luheshi LM, Dobson CM. Bridging the gap: From protein misfolding to protein misfolding diseases Febs Letters. 583: 2581-2586. PMID 19545568 DOI: 10.1016/j.febslet.2009.06.030  0.96
2009 White DA, Buell AK, Dobson CM, Welland ME, Knowles TP. Biosensor-based label-free assays of amyloid growth. Febs Letters. 583: 2587-92. PMID 19523953 DOI: 10.1016/j.febslet.2009.06.008  0.96
2009 Hsu STD, Cabrita LD, Fucini P, Christodoulou J, Dobson CM. Probing side-chain dynamics of a ribosome-bound nascent chain using methyl NMR spectroscopy Journal of the American Chemical Society. 131: 8366-8367. PMID 19492839 DOI: 10.1021/ja902778n  0.72
2009 Hsu STD, Bertoncini CW, Dobson CM. Use of protonless NMR spectroscopy to alleviate the loss of information resulting from exchange-broadening Journal of the American Chemical Society. 131: 7222-7223. PMID 19432443 DOI: 10.1021/ja902307q  0.56
2009 Haakensen M, Dobson CM, Hill JE, Ziola B. Reclassification of Pediococcus dextrinicus (Coster and White 1964) back 1978 (Approved Lists 1980) as Lactobacillus dextrinicus comb. nov., and emended description of the genus Lactobacillus. International Journal of Systematic and Evolutionary Microbiology. 59: 615-21. PMID 19244449 DOI: 10.1099/ijs.0.65779-0  0.44
2009 Robustelli P, Cavalli A, Dobson CM, Vendruscolo M, Salvatella X. Folding of small proteins by monte carlo simulations with chemical shift restraints without the use of molecular fragment replacement or structural homology Journal of Physical Chemistry B. 113: 7890-7896. DOI: 10.1021/jp900780b  0.56
1998 Dobson CM, Šali A, Karplus M. Protein Folding: A Perspective from Theory and Experiment. Angewandte Chemie (International Ed. in English). 37: 868-893. PMID 29711488 DOI: 10.1002/(SICI)1521-3773(19980420)37:7<868::AID-ANIE868>3.0.CO;2-H  1
1998 Guijarro JI, Morton CJ, Plaxco KW, Campbell ID, Dobson CM. Folding kinetics of the SH3 domain of PI3 kinase by real-time NMR combined with optical spectroscopy. Journal of Molecular Biology. 276: 657-67. PMID 9551103 DOI: 10.1006/jmbi.1997.1553  0.76
1998 Plaxco KW, Guijarro JI, Morton CJ, Pitkeathly M, Campbell ID, Dobson CM. The folding kinetics and thermodynamics of the Fyn-SH3 domain. Biochemistry. 37: 2529-37. PMID 9485402 DOI: 10.1021/bi972075u  0.72
1997 Plaxco KW, Morton CJ, Grimshaw SB, Jones JA, Pitkeathly M, Campbell ID, Dobson CM. The effects of guanidine hydrochloride on the 'random coil' conformations and NMR chemical shifts of the peptide series GGXGG. Journal of Biomolecular Nmr. 10: 221-30. PMID 20700831 DOI: 10.1023/A:1018340217891  0.76
1997 Plaxco KW, Spitzfaden C, Campbell ID, Dobson CM. A comparison of the folding kinetics and thermodynamics of two homologous fibronectin type III modules. Journal of Molecular Biology. 270: 763-70. PMID 9245603 DOI: 10.1006/jmbi.1997.1148  0.72
1996 Plaxco KW, Dobson CM. Time-resolved biophysical methods in the study of protein folding. Current Opinion in Structural Biology. 6: 630-6. PMID 8913685 DOI: 10.1016/S0959-440X(96)80029-7  1
1996 Plaxco KW, Spitzfaden C, Campbell ID, Dobson CM. Rapid refolding of a proline-rich all-beta-sheet fibronectin type III module. Proceedings of the National Academy of Sciences of the United States of America. 93: 10703-6. PMID 8855243 DOI: 10.1073/pnas.93.20.10703  0.76
1989 Evans PA, Kautz RA, Fox RO, Dobson CM. A magnetization-transfer nuclear magnetic resonance study of the folding of staphylococcal nuclease. Biochemistry. 28: 362-70. PMID 2706262  0.56
1987 Evans PA, Dobson CM, Kautz RA, Hatfull G, Fox RO. Proline isomerism in staphylococcal nuclease characterized by NMR and site-directed mutagenesis. Nature. 329: 266-8. PMID 3627269 DOI: 10.1038/329266a0  0.56
1987 Delepierre M, Dobson CM, Karplus M, Poulsen FM, States DJ, Wedin RE. Electrostatic effects and hydrogen exchange behaviour in proteins. The pH dependence of exchange rates in lysozyme. Journal of Molecular Biology. 197: 111-30. PMID 2824793 DOI: 10.1016/0022-2836(87)90613-9  1
1987 States DJ, Creighton TE, Dobson CM, Karplus M. Conformations of intermediates in the folding of the pancreatic trypsin inhibitor. Journal of Molecular Biology. 195: 731-9. PMID 2443711 DOI: 10.1016/0022-2836(87)90192-6  0.6
1986 Fox RO, Evans PA, Dobson CM. Multiple conformations of a protein demonstrated by magnetization transfer NMR spectroscopy. Nature. 320: 192-4. PMID 3951556 DOI: 10.1038/320192a0  0.6
1986 Post CB, Brooks BR, Karplus M, Dobson CM, Artymiuk PJ, Cheetham JC, Phillips DC. Molecular dynamics simulations of native and substrate-bound lysozyme. A study of the average structures and atomic fluctuations. Journal of Molecular Biology. 190: 455-79. PMID 3783708 DOI: 10.1016/0022-2836(86)90015-X  1
1985 Hoch JC, Dobson CM, Karplus M. Vicinal coupling constants and protein dynamics Biochemistry. 24: 3831-3841. PMID 4052369  1
1985 Boyd J, Dobson CM, Redfield C. Identification of glycine spin systems in 1H NMR spectra of proteins using multiple quantum coherences Febs Letters. 186: 35-40. PMID 4007158 DOI: 10.1016/0014-5793(85)81334-X  1
1985 Campbell ID, Dobson CM, Williams RJ. The study of conformational states of proteins by nuclear magnetic resonance. The Biochemical Journal. 231: 1-10. PMID 2998335  1
1985 Olejniczak ET, Hoch JC, Dobson CM, Poulsen FM. Quantitative measurement using pure-phase two-dimensional exchange spectroscopy Journal of Magnetic Resonance (1969). 64: 199-206. DOI: 10.1016/0022-2364(85)90344-0  1
1985 Boyd J, Dobson CM, Redfieldt C. Correlation of aliphatic proton chemical shifts in proteins using two-dimensional double-quantum correlated spectroscopy Journal of Magnetic Resonance (1969). 62: 543-550. DOI: 10.1016/0022-2364(85)90226-4  1
1984 States DJ, Dobson CM, Karplus M. A new two-disulphide intermediate in the refolding of reduced bovine pancreatic trypsin inhibitor. Journal of Molecular Biology. 174: 411-8. PMID 6201619 DOI: 10.1016/0022-2836(84)90345-0  0.44
1984 Delepierre M, Dobson CM, Howarth MA, Poulsen FM. Identification using 1H NMR spectroscopy of slowly exchanging amide hydrogens of hen lysozyme in solution European Journal of Biochemistry. 145: 389-395. PMID 6094189  1
1984 Munowitz MG, Huang TH, Dobson CM, Griffin RG. High-resolution dilute spin dipolar NMR spectroscopy in the solid state Journal of Magnetic Resonance (1969). 57: 56-64. DOI: 10.1016/0022-2364(84)90233-6  1
1984 Olejniczak ET, Poulsen FM, Dobson CM. Distance dependence of proton nuclear overhauser effects in proteins Journal of Magnetic Resonance (1969). 59: 518-523. DOI: 10.1016/0022-2364(84)90088-X  1
1984 Olejniczak ET, Dobson CM, Karplus M, Levy RM. MOTIONAL AVERAGING OF PROTON NUCLEAR OVERHAUSER EFFECTS IN PROTEINS. PREDICTIONS FROM A MOLECULAR DYNAMICS SIMULATION OF LYSOZYME Journal of the American Chemical Society. 106: 1923-1930.  1
1983 Delepierre M, Dobson CM, Selvarajah S, Wedin RE, Poulsen FM, Gilbert A. Correlation of hydrogen exchange behaviour and thermal stability of lysozyme Journal of Molecular Biology. 168: 687-692. PMID 6887252 DOI: 10.1016/S0022-2836(83)80309-X  1
1983 Bentley GA, Delepierre M, Dobson CM, Wedin RE, Mason SA, Poulsen FM. Exchange of individual hydrogens for a protein in a crystal and in solution Journal of Molecular Biology. 170: 243-247. PMID 6631963 DOI: 10.1016/S0022-2836(83)80235-6  1
1982 Delepierre M, Dobson CM, Poulsen FM. Studies of β-sheet structure in lysozyme by proton nuclear magnetic resonance. Assignments and analysis of spin-spin coupling constants Biochemistry. 21: 4756-4761. PMID 7138826  1
1982 Wedin RE, Delepierre M, Dobson CM, Poulsen FM. Mechanisms of hydrogen exchange in proteins from nuclear magnetic resonance studies of individual tryptophan indole NH hydrogens in lysozyme Biochemistry. 21: 1098-1103. PMID 7074052  1
1982 Dobson CM, Olejniczak ET, Poulsen FM, Ratcliffe RG. Time development of proton nuclear overhauser effects in proteins Journal of Magnetic Resonance (1969). 48: 97-110. DOI: 10.1016/0022-2364(82)90241-4  1
1981 Brown-Mason A, Dobson CM, Woodworth RC. Efficient incorporation of deuterated amino acids into quail egg white proteins for nuclear magnetic resonance studies Journal of Biological Chemistry. 256: 1506-1509. PMID 7462210  1
1981 Blake CC, Cassels R, Dobson CM, Poulsen FM, Williams RJ, Wilson KS. Structure and binding properties of hen lysozyme modified at tryptophan 62. Journal of Molecular Biology. 147: 73-95. PMID 7265240 DOI: 10.1016/0022-2836(81)90080-2  1
1981 Costa JL, Dobson CM, Fay DD, Kirk KL, Poulsen FM, Valeri CR, Vecchione JJ. Nuclear magnetic resonance studies of amine storage in pig platelets Febs Letters. 136: 325-328. PMID 6895733 DOI: 10.1016/0014-5793(81)80646-1  1
1981 Bodenhausen G, Dobson CM. Selective removal of magnetization in coupled NMR spectra Journal of Magnetic Resonance (1969). 44: 212-216. DOI: 10.1016/0022-2364(81)90204-3  1
1981 Olejniczak ET, Poulsen FM, Dobson CM. Proton nuclear Overhauser effects and protein dynamics Journal of the American Chemical Society. 103: 6574-6580.  1
1980 States DJ, Dobson CM, Karplus M, Creighton TE. A conformational isomer of bovine pancreatic trypsin inhibitor protein produced by refolding. Nature. 286: 630-2. PMID 7402343 DOI: 10.1038/286630a0  0.6
1980 Costa JL, Dobson CM, Kirk KL, Poulsen FM, Valeri CR, Vecchione JJ. Nuclear magnetic resonance studies of blood platelets Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 289: 413-423. PMID 6106216  1
1980 Cassels R, Dobson CM, Poulsen FM, Ratcliffe RG, Williams RJP. Transverse relaxation effects resulting from deuterium exchange in the proton NMR spectra of proteins Journal of Magnetic Resonance (1969). 37: 141-153. DOI: 10.1016/0022-2364(80)90099-2  1
1979 Cave A, Pages M, Morin P, Dobson CM. Conformational studies on muscular parvalbumins cooperative binding of calcium (II) to parvalbumins Biochimie. 61: 607-613. PMID 497251 DOI: 10.1016/S0300-9084(79)80158-3  1
1979 Woodworth RC, Dobson CM. Selective substitution of 2H and 3H into aromatic amino acids catalyzed by Raney nickel Febs Letters. 101: 329-332. PMID 446756 DOI: 10.1016/0014-5793(79)81036-4  1
1979 Costa JL, Dobson CM, Kirk KL, Poulsen FM, Valeri CR, Vecchione JJ. Studies of human platelets by 19F and 31P NMR. Febs Letters. 99: 141-6. PMID 437120 DOI: 10.1016/0014-5793(79)80266-5  1
1978 Dobson CM, Ferguson SJ, Poulsen FM, Williams RJ. Complete assignment of aromatic 1H nuclear magnetic resonances of the tyrosine residues of hen lysozyme. European Journal of Biochemistry / Febs. 92: 99-103. PMID 569580  1
1978 Cassels R, Dobson CM, Poulsen FM, Williams RJ. Study of the tryptophan residues of lysozyme using 1H nuclear magnetic resonance. European Journal of Biochemistry / Febs. 92: 81-97. PMID 32040  1
1978 Dobson CM, Geraldes CF, Ratcliffe G, Williams RJ. Nuclear-magnetic-resonance studies of 5'-ribonucleotide and 5'-deoxyribonucleotide conformations in solution using the lanthanide probe method. European Journal of Biochemistry / Febs. 88: 259-66. PMID 27362  1
1978 Campbell ID, Dobson CM, Ratcliffe RG, Williams RJP. A method for the accurate measurement of 1H spin-spin coupling constants in large molecules Journal of Magnetic Resonance (1969). 31: 341-345. DOI: 10.1016/0022-2364(78)90198-1  1
1978 Campbell ID, Dobson CM, Ratcliffe RG, Williams RJP. Fourier transform NMR pulse methods for the measurement of slow-exchange rates Journal of Magnetic Resonance (1969). 29: 397-417. DOI: 10.1016/0022-2364(78)90001-X  1
1977 Blake CC, Grace DE, Johnson LN, Perkins SJ, Phillips DC, Cassels R, Dobson CM, Poulsen FM, Williams RJ. Physical and chemical properties of lysozyme. Ciba Foundation Symposium. 137-85. PMID 252451  1
1976 Cave A, Dobson CM, Parello J, Williams RJ. Conformation mobility within the structure of muscular parvalbumins. An NMR study of the aromatic resonances of phenylalanine residues. Febs Letters. 65: 190-4. PMID 1278422  1
1976 Campbell ID, Dobson CM, Moore GR, Perkins SJ, Williams RJ. Temperature dependent molecular motion of a tyrosine residue of ferrocytochrome C. Febs Letters. 70: 96-100. PMID 186328  1
1975 Campbell ID, Dobson CM, Williams RJ, Wright PE. Pulse methods for the simplification of protein NMR spectra. Febs Letters. 57: 96-9. PMID 1175783  1
1975 Dobson CM, Williams RJ. An NMR study of the dynamics of inhibitor-induced conformational changes in lysozyme. Febs Letters. 56: 362-5. PMID 1171786 DOI: 10.1016/0014-5793(75)81128-8  1
1975 Campbell ID, Dobson CM, Williams RJ. Proton magnetic resonance studies of the tyrosine residues of hen lysozyme-assignment and detection of conformational mobility. Proceedings of the Royal Society of London. Series B, Biological Sciences. 189: 503-9. PMID 237281  1
1975 Dobson CM, Moore GR, Williams RJ. Assignment of aromatic amino acid PMR resonances of horse ferricytochrome c. Febs Letters. 51: 60-5. PMID 235463 DOI: 10.1016/0014-5793(75)80854-4  1
1974 Campbell ID, Dobson CM, Jeminet G, Williams RJ. Pulsed NMR methods for the observation and assignment of exchangeable hydrogens: application to bacitracin. Febs Letters. 49: 115-9. PMID 4442586 DOI: 10.1016/0014-5793(74)80645-9  1
1974 Dobson CM, Hoyle NJ, Geraldes CF, Bruschi M, LeGall J, Wright PE, Williams RJ. Outline structure of cytochrome c3 and consideration of its properties. Nature. 249: 425-9. PMID 4365942  1
1973 Campbell ID, Dobson CM, Williams RJ, Xavier AV. The determination of the structure of proteins in solution: lysozyme. Annals of the New York Academy of Sciences. 222: 163-74. PMID 4522426  0.6
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