| Year |
Citation |
Score |
| 2011 |
Raches DW, Xiao S, Kusumanchi P, Yalowitz J, Sanghani P, Long EC, Antony AC, Jayaram HN. Cloning, expression and characterization of mouse (Mus musculus) nicotinamide 5'-mononucleotide adenylyltransferase-2. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 7: 718-26. PMID 22313312 DOI: 10.2174/157340611797928262 |
0.725 |
|
| 2011 |
Jayaram HN, Kusumanchi P, Yalowitz JA. NMNAT expression and its relation to NAD metabolism. Current Medicinal Chemistry. 18: 1962-72. PMID 21517776 |
0.738 |
|
| 2010 |
Kusumanchi P, Zhang Y, Chakka P, Jayaram NH, Khan R, Antony AC, Jayaram HN. Abstract 1506: Prodrug targeted gene therapy for colorectal cancer Cancer Research. 70: 1506-1506. DOI: 10.1158/1538-7445.Am10-1506 |
0.333 |
|
| 2008 |
Cappellacci L, Franchetti P, Vita P, Petrelli R, Lavecchia A, Jayaram HN, Saiko P, Graser G, Szekeres T, Grifantini M. Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. Journal of Medicinal Chemistry. 51: 4260-9. PMID 18588281 DOI: 10.1021/Jm800205C |
0.393 |
|
| 2007 |
Bonnac LF, Gao GY, Chen L, Patterson SE, Jayaram HN, Pankiewicz KW. Efficient synthesis of benzamide riboside, a potential anticancer agent. Nucleosides, Nucleotides & Nucleic Acids. 26: 1249-53. PMID 18066762 DOI: 10.1080/15257770701528222 |
0.307 |
|
| 2005 |
Franchetti P, Cappellacci L, Pasqualini M, Petrelli R, Vita P, Jayaram HN, Horvath Z, Szekeres T, Grifantini M. Antitumor activity of C-methyl-beta-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors. Journal of Medicinal Chemistry. 48: 4983-9. PMID 16033277 DOI: 10.1021/Jm048944C |
0.401 |
|
| 2004 |
Pankiewicz KW, Patterson SE, Black PL, Jayaram HN, Risal D, Goldstein BM, Stuyver LJ, Schinazi RF. Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target. Current Medicinal Chemistry. 11: 887-900. PMID 15083807 DOI: 10.2174/0929867043455648 |
0.359 |
|
| 2004 |
Yalowitz JA, Xiao S, Biju MP, Antony AC, Cummings OW, Deeg MA, Jayaram HN. Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas. The Biochemical Journal. 377: 317-26. PMID 14516279 DOI: 10.1042/Bj20030518 |
0.735 |
|
| 2002 |
Yalowitz JA, Pankiewicz K, Patterson SE, Jayaram HN. Cytotoxicity and cellular differentiation activity of methylenebis(phosphonate) analogs of tiazofurin and mycophenolic acid adenine dinucleotide in human cancer cell lines. Cancer Letters. 181: 31-8. PMID 12430176 DOI: 10.1016/S0304-3835(02)00045-9 |
0.747 |
|
| 2002 |
Jayaram HN, Yalowitz JA, Arguello F, Greene JF. Toxicity and efficacy of benzamide riboside in cancer chemotherapy models. Current Medicinal Chemistry. 9: 787-92. PMID 11966443 DOI: 10.2174/0929867024606858 |
0.728 |
|
| 2002 |
Yalowitz JA, Jayaram HN. Modulation of cytotoxicity of benzamide riboside by expression of NMN adenylyltransferase. Current Medicinal Chemistry. 9: 749-58. PMID 11966438 DOI: 10.2174/0929867024606867 |
0.763 |
|
| 2002 |
Gharehbaghi K, Grünberger W, Jayaram HN. Studies on the mechanism of action of benzamide riboside: a novel inhibitor of IMP dehydrogenase. Current Medicinal Chemistry. 9: 743-8. PMID 11966437 DOI: 10.2174/0929867024606902 |
0.45 |
|
| 2002 |
Pankiewicz KW, Watanabe KA, Lesiak-Watanabe K, Goldstein BM, Jayaram HN. The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside. Current Medicinal Chemistry. 9: 733-41. PMID 11966436 DOI: 10.2174/0929867024606920 |
0.463 |
|
| 2002 |
Pankiewicz KW, Lesiak-Watanabe KB, Watanabe KA, Patterson SE, Jayaram HN, Yalowitz JA, Miller MD, Seidman M, Majumdar A, Prehna G, Goldstein BM. Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia. Journal of Medicinal Chemistry. 45: 703-12. PMID 11806722 DOI: 10.1021/Jm0104116 |
0.745 |
|
| 2001 |
Franchetti P, Marchetti S, Cappellacci L, Yalowitz JA, Jayaram HN, Goldstein BM, Grifantini M. A new C-nucleoside analogue of tiazofurin: synthesis and biological evaluation of 2-beta-D-ribofuranosylimidazole-4-carboxamide (imidazofurin). Bioorganic & Medicinal Chemistry Letters. 11: 67-9. PMID 11140736 DOI: 10.1016/S0960-894X(00)00594-1 |
0.754 |
|
| 2001 |
Franchetti P, Marchetti S, Cappellacci L, Yalowitz JA, Jayaram HN, Goldstein BM, Grifantini M. ChemInform Abstract: A New C-Nucleoside Analogue of Tiazofurin: Synthesis and Biological Evaluation of 2-β-D-Ribofuranosylimidazole-4-carboxamide (Imidazofurin). Cheminform. 32: no-no. DOI: 10.1002/CHIN.200118194 |
0.725 |
|
| 2000 |
Gharehbaghi K, Szekeres T, Yalowitz JA, Fritzer-Szekeres M, Pommier YG, Jayaram HN. Sensitizing human colon carcinoma HT-29 cells to cisplatin by cyclopentenylcytosine, in vitro and in vivo. Life Sciences. 68: 1-11. PMID 11132239 DOI: 10.1016/S0024-3205(00)00914-0 |
0.716 |
|
| 2000 |
Yalowitz JA, Jayaram HN. Molecular targets of guanine nucleotides in differentiation, proliferation and apoptosis. Anticancer Research. 20: 2329-38. PMID 10953293 |
0.753 |
|
| 2000 |
Franchetti P, Marchetti S, Cappellacci L, Jayaram HN, Yalowitz JA, Goldstein BM, Barascut JL, Dukhan D, Imbach JL, Grifantini M. Synthesis, conformational analysis, and biological activity of C-thioribonucleosides related to tiazofurin. Journal of Medicinal Chemistry. 43: 1264-70. PMID 10753464 DOI: 10.1021/Jm990257B |
0.746 |
|
| 1998 |
Franchetti P, Cappellacci L, Perlini P, Jayaram HN, Butler A, Schneider BP, Collart FR, Huberman E, Grifantini M. Isosteric analogues of nicotinamide adenine dinucleotide derived from furanfurin, thiophenfurin, and selenophenfurin as mammalian inosine monophosphate dehydrogenase (type I and II) inhibitors Journal of Medicinal Chemistry. 41: 1702-1707. PMID 9572896 DOI: 10.1021/Jm970772E |
0.374 |
|
| 1997 |
Franchetti P, Cappellacci L, Sheikha GA, Jayaram HN, Gurudutt VV, Sint T, Schneider BP, Jones WD, Goldstein BM, Perra G, De Montis A, Loi AG, La Colla P, Grifantini M. Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin. Journal of Medicinal Chemistry. 40: 1731-7. PMID 9171883 DOI: 10.1021/Jm960864O |
0.409 |
|
| 1997 |
Cappellacci L, Franchetti P, Sheikha GA, Jayaram HN, Gurudutt VV, Sint T, Schneider BP, Goldstein BM, Perra G, Poma S, La Colla P, Grifantini M. Synthesis and Cytotoxic Activity of Selenophenfurin, a New Inhibitor of IMP Dehydrogenase Nucleosides and Nucleotides. 16: 1045-1048. DOI: 10.1080/07328319708006129 |
0.302 |
|
| 1995 |
Franchetti P, Cappellacci L, Grifantini M, Barzi A, Nocentini G, Yang H, O'Connor A, Jayaram HN, Carrell C, Goldstein BM. Furanfurin and thiophenfurin: Two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase Journal of Medicinal Chemistry. 38: 3829-3837. PMID 7562914 DOI: 10.1021/Jm00019A013 |
0.367 |
|
| 1994 |
Gharehbaghi K, Sreenath A, Hao Z, Paull KD, Szekeres T, Cooney DA, Krohn K, Jayaram HN. Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin. Biochemical Pharmacology. 48: 1413-9. PMID 7945441 DOI: 10.1016/0006-2952(94)90565-7 |
0.371 |
|
| 1994 |
Gharehbaghi K, Paull KD, Kelley JA, Barchi JJ, Marquez VE, Cooney DA, Monks A, Scudiero D, Krohn K, Jayaram HN. Cytotoxicity and characterization of an active metabolite of benzamide riboside, a novel inhibitor of IMP dehydrogenase International Journal of Cancer. 56: 892-899. PMID 7907081 DOI: 10.1002/Ijc.2910560623 |
0.36 |
|
| 1993 |
Pankiewicz KW, Zeidler J, Ciszewski LA, Bell JE, Goldstein BM, Jayaram HN, Watanabe KA. Synthesis of isosteric analogues of nicotinamide adenine dinucleotide containing C-nucleotide of nicotinamide or picolinamide. Journal of Medicinal Chemistry. 36: 1855-9. PMID 8099976 DOI: 10.1021/Jm00065A008 |
0.426 |
|
| 1992 |
Jayaram HN, Gharehbaghi K, Jayaram NH, Rieser J, Krohn K, Paull KD. Cytotoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells. Biochemical and Biophysical Research Communications. 186: 1600-6. PMID 1354960 DOI: 10.1016/S0006-291X(05)81591-8 |
0.318 |
|
| 1991 |
Weber G, Nagai M, Natsumeda Y, Ichikawa S, Nakamura H, Eble JN, Jayaram HN, Zhen WN, Paulik E, Hoffman R. Regulation of de novo and salvage pathways in chemotherapy. Advances in Enzyme Regulation. 31: 45-67. PMID 1877399 DOI: 10.1016/0065-2571(91)90008-A |
0.301 |
|
| 1991 |
Weber G, Nagai M, Natsumeda Y, Eble JN, Jayaram HN, Paulik E, Zhen WN, Hoffman R, Tricot G. Tiazofurin down-regulates expression of c-Ki-ras oncogene in a leukemic patient. Cancer Communications. 3: 61-6. PMID 1705812 DOI: 10.3727/095535491820873579 |
0.358 |
|
| 1986 |
Ahluwalia GS, Cooney DA, Marquez VE, Jayaram HN, Johns DG. Studies on the mechanism of action of tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide). VI. Biochemical and pharmacological studies on the degradation of thiazole-4-carboxamide adenine dinucleotide (TAD). Biochemical Pharmacology. 35: 3783-90. PMID 2877671 DOI: 10.1016/0006-2952(86)90665-9 |
0.421 |
|
| 1985 |
Batist G, Klecker RW, Jayaram HN, Jenkins JF, Grygiel J, Ihde DC, Eddy JL, Fine RL, Kerr IG, Collins JM. Phase I and pharmacokinetic study of tiazofurin (TCAR, NSC 286193) administered by continuous infusion. Investigational New Drugs. 3: 349-55. PMID 4086242 DOI: 10.1007/Bf00170757 |
0.323 |
|
| 1985 |
Gebeyehu G, Marquez VE, Van Cott A, Cooney DA, Kelley JA, Jayaram HN, Ahluwalia GS, Dion RL, Wilson YA, Johns DG. Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase. Journal of Medicinal Chemistry. 28: 99-105. PMID 2856943 DOI: 10.1021/Jm00379A018 |
0.352 |
|
| 1985 |
Carney DN, Ahluwalia GS, Jayaram HN, Cooney DA, Johns DG. Relationships between the cytotoxicity of tiazofurin and its metabolism by cultured human lung cancer cells. The Journal of Clinical Investigation. 75: 175-82. PMID 2856924 DOI: 10.1172/Jci111671 |
0.433 |
|
| 1984 |
Gebeyehu G, Marquez VE, Kelley JA, Cooney DA, Jayaram HN, Johns DG. Synthesis Of Thiazole-4-Carboxamide Adenine Dinucleotide. A Powerful Inhibitor Of Imp Dehydrogenase Cheminform. 15. DOI: 10.1002/Chin.198409337 |
0.302 |
|
| 1983 |
Cooney DA, Jayaram HN, Glazer RI, Kelley JA, Marquez VE, Gebeyehu G, Van Cott AC, Zwelling LA, Johns DG. Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity. Advances in Enzyme Regulation. 21: 271-303. PMID 6152729 DOI: 10.1016/0065-2571(83)90019-5 |
0.405 |
|
| 1983 |
Jayaram HN, Ahluwalia GS, Dion RL, Gebeyehu G, Marquez VE, Kelley JA, Robins RK, Cooney DA, Johns DG. Conversion of 2-beta-D-ribofuranosylselenazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties. Biochemical Pharmacology. 32: 2633-6. PMID 6137224 DOI: 10.1016/0006-2952(83)90038-2 |
0.35 |
|
| 1983 |
Gebeyehu G, Marquez VE, Kelley JA, Cooney DA, Jayaram HN, Johns DG. Synthesis of thiazole-4-carboxamide adenine dinucleotide. A powerful inhibitor of IMP dehydrogenase. Journal of Medicinal Chemistry. 26: 922-5. PMID 6133956 DOI: 10.1021/Jm00360A025 |
0.389 |
|
| 1983 |
Jayaram HN, Smith AL, Glazer RI, Johns DG, Cooney DA. Studies on the mechanism of action of 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC 286193)--II. Relationship between dose level and biochemical effects in P388 leukemia in vivo. Biochemical Pharmacology. 31: 3839-45. PMID 6130768 DOI: 10.1016/0006-2952(82)90300-8 |
0.387 |
|
| 1982 |
Jayaram HN, Cooney DA, Glazer RI, Dion RL, Johns DG. Mechanism of resistance to the oncolytic C-nucleoside 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC-286193). Biochemical Pharmacology. 31: 2557-60. PMID 7126269 DOI: 10.1016/0006-2952(82)90071-5 |
0.33 |
|
| 1982 |
Kensler TW, Jayaram HN, Cooney DA. Effects of acivicin and PALA, singly and in combination, on de novo pyrimidine biosynthesis. Advances in Enzyme Regulation. 20: 57-73. PMID 7113804 DOI: 10.1016/0065-2571(82)90008-5 |
0.371 |
|
| 1982 |
Ardalan B, Arakawa M, Villacorte D, Jayaram H, Cooney DA. Effect of L-glutamine antagonists on 5-phosphoribosyl 1-pyrophosphate levels in P388 leukemia and in murine colon adenocarcinomas in vivo. Biochemical Pharmacology. 31: 1509-13. PMID 6178415 DOI: 10.1016/0006-2952(82)90373-2 |
0.322 |
|
| 1982 |
Jayaram HN, Dion RL, Glazer RI, Johns DG, Robins RK, Srivastava PC, Cooney DA. Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC 286193). Biochemical Pharmacology. 31: 2371-80. PMID 6127085 DOI: 10.1016/0006-2952(82)90532-9 |
0.42 |
|
| 1982 |
Cooney DA, Jayaram HN, Gebeyehu G, Betts CR, Kelley JA, Marquez VE, Johns DG. The conversion of 2-beta-D-ribofuranosylthiazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties. Biochemical Pharmacology. 31: 2133-6. PMID 6126195 DOI: 10.1016/0006-2952(82)90436-1 |
0.35 |
|
| 1981 |
Ardalan B, Glazer RI, Kensler TW, Jayaram HN, Van Pham T, Macdonald JS, Cooney DA. Synergistic effect of 5-fluorouracil and N-(phosphonacetyl)-L-aspartate on cell growth and ribonucleic acid synthesis in human mammary carcinoma. Biochemical Pharmacology. 30: 2045-9. PMID 7295324 DOI: 10.1016/0006-2952(81)90221-5 |
0.308 |
|
| 1981 |
Tyagi AK, Cooney DA, Jayaram HN, Swiniarski JK, Johnson RK. Studies on the mechanism of resistance of selected murine tumors to L-alanosine. Biochemical Pharmacology. 30: 915-924. PMID 7236312 DOI: 10.1016/0006-2952(81)90034-4 |
0.306 |
|
| 1980 |
Tyagi AK, Cooney DA, Bledsoe M, Jayaram HN. Two complementary radiometric methods for the measurement of 5-amino-4-imidazole-N-succinocarboxamide ribonucleotide synthetase (SAICAR synthetase). Journal of Biochemical and Biophysical Methods. 2: 123-132. PMID 6999069 DOI: 10.1016/0165-022X(80)90019-6 |
0.345 |
|
| 1980 |
Kensler TW, Jayaram HN, Cooney DA. A facile enzymatic technique for the estimation of nanomolar concentrations of N-phosphonacetyl-L-aspartic acid in plasma. Journal of Biochemical and Biophysical Methods. 2: 29-35. PMID 6999068 DOI: 10.1016/0165-022X(80)90071-8 |
0.308 |
|
| 1980 |
Cooney DA, Jones MT, Milman HA, Young DM, Jayaram HN. Regulators of the metabolism of L-asparagine: a search for endogenous inhibitors. The International Journal of Biochemistry. 11: 519-39. PMID 6103827 DOI: 10.1016/0020-711X(80)90261-X |
0.333 |
|
| 1980 |
Jayaram HN, Tyagi AK, Anandaraj S, Montgomery JA, Kelley JA, Kelley J, Adamson RH, Cooney DA. Metabolites of alanosine, an antitumor antibiotic. Biochemical Pharmacology. 28: 3551-66. PMID 533558 DOI: 10.1016/0006-2952(79)90400-3 |
0.378 |
|
| 1976 |
Cooney DA, Jayaram HN, Milman HA, Homan ER, Pittillo R, Geran RI, Ryan J, Rosenbluth RJ. DON, CONV and DONV—III. Pharmacologic and toxicologic studies Biochemical Pharmacology. 25: 1859-1870. PMID 9092 DOI: 10.1016/0006-2952(76)90190-8 |
0.322 |
|
| 1976 |
Rosenbluth RJ, Cooney DA, Jayaram HN, Milman HA, Homan ER. DON, CONV and DONV—II. Inhibition of l-asparagine synthetase in vivo Biochemical Pharmacology. 25: 1851-1858. PMID 9091 DOI: 10.1016/0006-2952(76)90189-1 |
0.317 |
|
| 1975 |
Jayaram HN, Cooney DA, Milman HA, Homan ER, King WM, Cragoe EJ. Ethacrynic acid--an inhibitor of L-asparagine synthetase. Biochemical Pharmacology. 24: 1787-92. PMID 9943 DOI: 10.1016/0006-2952(75)90458-X |
0.358 |
|
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