Emily Balskus - Publications

Harvard University, Cambridge, MA, United States 
microbial chemistry

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ng TL, McCallum ME, Zheng CR, Wang JX, Wu K, Balskus EP. The L -alanosine gene cluster encodes a pathway for diazeniumdiolate biosynthesis. Chembiochem : a European Journal of Chemical Biology. PMID 31643127 DOI: 10.1002/cbic.201900565  0.32
2019 Chen S, Henderson A, Petriello M, Romano KA, Gearing M, Miao J, Schell M, Sandoval-EspinolaEspinola WJ, Tao J, Sha B, Graham M, Crooke R, Kleinridders A, Balskus EP, Rey FE, et al. Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction. Cell Metabolism. PMID 31543404 DOI: 10.1016/j.cmet.2019.08.021  0.36
2019 Volpe MR, Wilson MR, Brotherton CA, Winter ES, Johnson SE, Balskus EP. Characterization of the Colibactin-Activating Peptidase ClbP Enables Design of a Fluorogenic Activity Probe. Acs Chemical Biology. PMID 31411848 DOI: 10.1021/acschembio.9b00540  0.32
2019 Jiang Y, Stornetta A, Villalta PW, Wilson MR, Boudreau PD, Zha L, Balbo S, Balskus EP. The reactivity of an unusual amidase may explain colibactin's DNA cross-linking activity. Journal of the American Chemical Society. PMID 31251062 DOI: 10.1021/jacs.9b02453  0.32
2019 Volpe MR, Wilson MR, Brotherton CA, Winter ES, Johnson SE, Balskus EP. In vitro characterization of the colibactin-activating peptidase ClbP enables development of a fluorogenic activity probe. Acs Chemical Biology. PMID 31059217 DOI: 10.1021/acschembio.9b00069  0.32
2019 Wilson MR, Jiang Y, Villalta PW, Stornetta A, Boudreau PD, Carrá A, Brennan CA, Chun E, Ngo L, Samson LD, Engelward BP, Garrett WS, Balbo S, Balskus EP. The human gut bacterial genotoxin colibactin alkylates DNA. Science (New York, N.Y.). 363. PMID 30765538 DOI: 10.1126/science.aar7785  0.32
2019 Ng TL, Rohac R, Mitchell AJ, Boal AK, Balskus EP. An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin. Nature. 566: 94-99. PMID 30728519 DOI: 10.1038/s41586-019-0894-z  0.32
2019 Schultz EE, Braffman NR, Luescher MU, Hager HH, Balskus EP. Biocatalytic Friedel-Crafts Alkylation Using a Promiscuous Biosynthetic Enzyme. Angewandte Chemie (International Ed. in English). PMID 30706984 DOI: 10.1002/anie.201814016  0.52
2018 Chittim CL, Martínez Del Campo A, Balskus EP. Gut bacterial phospholipase Ds support disease-associated metabolism by generating choline. Nature Microbiology. PMID 30455469 DOI: 10.1038/s41564-018-0294-4  0.4
2018 Wang KA, Ng TL, Wang P, Huang Z, Balskus EP, van der Donk WA. Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin. Nature Communications. 9: 3687. PMID 30206228 DOI: 10.1038/s41467-018-06083-7  0.32
2018 Dorrestein PC, Balskus EP. Chemical signaling at the eukaryotic/prokaryotic interface. Chemical Society Reviews. PMID 29479607 DOI: 10.1039/c8cs90021c  0.76
2017 Romano KA, Martinez-Del Campo A, Kasahara K, Chittim CL, Vivas EI, Amador-Noguez D, Balskus EP, Rey FE. Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption. Cell Host & Microbe. PMID 28844887 DOI: 10.1016/j.chom.2017.07.021  0.4
2017 Zha L, Jiang Y, Henke MT, Wilson MR, Wang JX, Kelleher NL, Balskus EP. Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring. Nature Chemical Biology. PMID 28805802 DOI: 10.1038/nchembio.2448  0.32
2017 Nakamura H, Schultz EE, Balskus EP. A new strategy for aromatic ring alkylation in cylindrocyclophane biosynthesis. Nature Chemical Biology. PMID 28671684 DOI: 10.1038/nchembio.2421  0.52
2017 Wilson MR, Zha L, Balskus EP. Natural Product Discovery from the Human Microbiome. The Journal of Biological Chemistry. PMID 28389564 DOI: 10.1074/jbc.R116.762906  0.32
2017 Waldman AJ, Ng TL, Wang P, Balskus EP. Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis. Chemical Reviews. PMID 28375000 DOI: 10.1021/acs.chemrev.6b00621  0.32
2017 Wang P, Hong G, Wilson MR, Balskus EP. Production of stealthin C involves an S-N-type Smiles rearrangement. Journal of the American Chemical Society. PMID 28191843 DOI: 10.1021/jacs.6b10586  0.32
2016 Martínez-Del Campo A, Romano KA, Rey FE, Balskus EP. The Plot Thickens: Diet Microbe Interactions May Modulate Thrombosis Risk. Cell Metabolism. 23: 573-5. PMID 27076072 DOI: 10.1016/j.cmet.2016.03.017  1
2016 Zha L, Wilson MR, Brotherton CA, Balskus EP. Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin. Acs Chemical Biology. PMID 26890481 DOI: 10.1021/acschembio.6b00014  0.32
2015 Waldman AJ, Pechersky Y, Wang P, Wang JX, Balskus EP. Back Cover: The Cremeomycin Biosynthetic Gene Cluster Encodes a Pathway for Diazo Formation (ChemBioChem 15/2015). Chembiochem : a European Journal of Chemical Biology. 16: 2254. PMID 26444309 DOI: 10.1002/cbic.201500461  0.32
2015 Balskus EP. Colibactin: understanding an elusive gut bacterial genotoxin. Natural Product Reports. 32: 1534-40. PMID 26390983 DOI: 10.1039/c5np00091b  1
2015 Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Balskus EP, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/nchembio.1890  1
2015 Waldman AJ, Pechersky Y, Wang P, Wang JX, Balskus EP. The cremeomycin biosynthetic gene cluster encodes a pathway for diazo formation. Chembiochem : a European Journal of Chemical Biology. PMID 26278892 DOI: 10.1002/cbic.201500407  1
2015 Leão PN, Nakamura H, Costa M, Pereira AR, Martins R, Vasconcelos V, Gerwick WH, Balskus EP. Biosynthesis-Assisted Structural Elucidation of the Bartolosides, Chlorinated Aromatic Glycolipids from Cyanobacteria. Angewandte Chemie (International Ed. in English). PMID 26235728 DOI: 10.1002/anie.201503186  1
2015 Brotherton CA, Balskus EP. Shedding light on sunscreen biosynthesis in zebrafish. Elife. 4. PMID 25965307 DOI: 10.7554/eLife.07961  1
2015 Brotherton CA, Wilson M, Byrd G, Balskus EP. Correction to Isolation of a Metabolite from the pks Island Provides Insights into Colibactin Biosynthesis and Activity. Organic Letters. 17: 2294. PMID 25893436 DOI: 10.1021/acs.orglett.5b01056  1
2015 Martínez-del Campo A, Bodea S, Hamer HA, Marks JA, Haiser HJ, Turnbaugh PJ, Balskus EP. Characterization and detection of a widely distributed gene cluster that predicts anaerobic choline utilization by human gut bacteria. Mbio. 6. PMID 25873372 DOI: 10.1128/mBio.00042-15  0.56
2015 Brotherton CA, Wilson M, Byrd G, Balskus EP. Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity. Organic Letters. 17: 1545-8. PMID 25753745 DOI: 10.1021/acs.orglett.5b00432  1
2015 Wallace S, Schultz EE, Balskus EP. Using non-enzymatic chemistry to influence microbial metabolism. Current Opinion in Chemical Biology. 25: 71-9. PMID 25579453 DOI: 10.1016/j.cbpa.2014.12.024  0.52
2015 Nakamura H, Wang JX, Balskus EP. Assembly line termination in cylindrocyclophane biosynthesis: discovery of an editing type II thioesterase domain in a type I polyketide synthase Chemical Science. 6: 3816-3822. DOI: 10.1039/c4sc03132f  1
2014 Janso JE, Haltli BA, Eustáquio AS, Kulowski K, Waldman AJ, Zha L, Nakamura H, Bernan VS, He H, Carter GT, Koehn FE, Balskus EP. Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica. Tetrahedron. 70: 4156-4164. PMID 25045187 DOI: 10.1016/j.tet.2014.03.009  1
2014 Balskus EP. Natural products: Sponge symbionts play defense. Nature Chemical Biology. 10: 611-2. PMID 25036309 DOI: 10.1038/nchembio.1588  1
2014 Sirasani G, Tong L, Balskus EP. A biocompatible alkene hydrogenation merges organic synthesis with microbial metabolism. Angewandte Chemie (International Ed. in English). 53: 7785-8. PMID 24916924 DOI: 10.1002/anie.201403148  1
2014 Craciun S, Marks JA, Balskus EP. Characterization of choline trimethylamine-lyase expands the chemistry of glycyl radical enzymes. Acs Chemical Biology. 9: 1408-13. PMID 24854437 DOI: 10.1021/cb500113p  1
2014 Haiser HJ, Seim KL, Balskus EP, Turnbaugh PJ. Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics. Gut Microbes. 5: 233-8. PMID 24637603 DOI: 10.4161/gmic.27915  1
2014 Waldman AJ, Balskus EP. Lomaiviticin biosynthesis employs a new strategy for starter unit generation. Organic Letters. 16: 640-3. PMID 24383813 DOI: 10.1021/ol403714g  1
2013 Lee Y, Umeano A, Balskus EP. Rescuing auxotrophic microorganisms with nonenzymatic chemistry. Angewandte Chemie (International Ed. in English). 52: 11800-3. PMID 24115592 DOI: 10.1002/anie.201307033  1
2013 Haiser HJ, Gootenberg DB, Chatman K, Sirasani G, Balskus EP, Turnbaugh PJ. Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta. Science (New York, N.Y.). 341: 295-8. PMID 23869020 DOI: 10.1126/science.1235872  1
2013 Brotherton CA, Balskus EP. A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicity. Journal of the American Chemical Society. 135: 3359-62. PMID 23406518 DOI: 10.1021/ja312154m  1
2013 Nakamura H, Balskus EP. Using chemical knowledge to uncover new biological function: Discovery of the cylindrocyclophane biosynthetic pathway Synlett. 24: 1464-1470. DOI: 10.1055/s-0033-1338879  1
2012 Craciun S, Balskus EP. Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme. Proceedings of the National Academy of Sciences of the United States of America. 109: 21307-12. PMID 23151509 DOI: 10.1073/pnas.1215689109  1
2012 Nakamura H, Hamer HA, Sirasani G, Balskus EP. Cylindrocyclophane biosynthesis involves functionalization of an unactivated carbon center. Journal of the American Chemical Society. 134: 18518-21. PMID 23106426 DOI: 10.1021/ja308318p  1
2011 Balskus EP, Case RJ, Walsh CT. The biosynthesis of cyanobacterial sunscreen scytonemin in intertidal microbial mat communities. Fems Microbiology Ecology. 77: 322-32. PMID 21501195 DOI: 10.1111/j.1574-6941.2011.01113.x  1
2010 Balskus EP, Walsh CT. The genetic and molecular basis for sunscreen biosynthesis in cyanobacteria. Science (New York, N.Y.). 329: 1653-6. PMID 20813918 DOI: 10.1126/science.1193637  1
2009 Balskus EP, Walsh CT. An enzymatic cyclopentyl[b]indole formation involved in scytonemin biosynthesis. Journal of the American Chemical Society. 131: 14648-9. PMID 19780555 DOI: 10.1021/ja906752u  1
2008 Balskus EP, Walsh CT. Investigating the initial steps in the biosynthesis of cyanobacterial sunscreen scytonemin. Journal of the American Chemical Society. 130: 15260-1. PMID 18954141 DOI: 10.1021/ja807192u  1
2008 Groll M, Balskus EP, Jacobsen EN. Structural analysis of spiro beta-lactone proteasome inhibitors. Journal of the American Chemical Society. 130: 14981-3. PMID 18928262 DOI: 10.1021/ja806059t  1
2008 Smith TE, Kuo WH, Balskus EP, Bock VD, Roizen JL, Theberge AB, Carroll KA, Kurihara T, Wessler JD. Total synthesis of (-)-hennoxazole A. The Journal of Organic Chemistry. 73: 142-50. PMID 18052386 DOI: 10.1021/jo7018015  1
2007 Balskus EP, Jacobsen EN. Asymmetric catalysis of the transannular Diels-Alder reaction. Science (New York, N.Y.). 317: 1736-40. PMID 17885133 DOI: 10.1126/science.1146939  1
2007 Bull JA, Balskus EP, Horan RA, Langner M, Ley SV. Total synthesis of potent antifungal marine bisoxazole natural products bengazoles A and B. Chemistry (Weinheim An Der Bergstrasse, Germany). 13: 5515-38. PMID 17440905 DOI: 10.1002/chem.200700033  1
2007 Smith TE, Kuo WH, Bock VD, Roizen JL, Balskus EP, Theberge AB. Total synthesis of (-)-hennoxazole A. Organic Letters. 9: 1153-5. PMID 17316014 DOI: 10.1021/ol070244p  1
2006 Bull JA, Balskus EP, Horan RA, Langner M, Ley SV. Stereocontrolled total synthesis of bengazole a: a marine bisoxazole natural product displaying potent antifungal properties. Angewandte Chemie (International Ed. in English). 45: 6714-8. PMID 16986186 DOI: 10.1002/anie.200602050  1
2006 Balskus EP, Jacobsen EN. Alpha,beta-unsaturated beta-silyl imide substrates for catalytic, enantioselective conjugate additions: a total synthesis of (+)-lactacystin and the discovery of a new proteasome inhibitor. Journal of the American Chemical Society. 128: 6810-2. PMID 16719460 DOI: 10.1021/ja061970a  1
2004 Ley SV, Antonello A, Balskus EP, Booth DT, Christensen SB, Cleator E, Gold H, Högenauer K, Hünger U, Myers RM, Oliver SF, Simic O, Smith MD, Søhoel H, Woolford AJ. Synthesis of the thapsigargins. Proceedings of the National Academy of Sciences of the United States of America. 101: 12073-8. PMID 15226504 DOI: 10.1073/pnas.0403300101  1
2003 MacCoss RN, Balskus EP, Ley SV. A sequential tetra-n-propylammonium perruthenate (TPAP)-Wittig oxidation olefination protocol Tetrahedron Letters. 44: 7779-7781. DOI: 10.1016/j.tetlet.2003.08.081  1
2003 Balskus EP, Ley SV. Rhodium-catalyzed coupling of heterocycles and alkenes: A novel mechanism of C-H activation Chemtracts. 16: 443-450.  1
2002 Smith TE, Balskus EP. Synthetic studies toward hennoxazole A. Use of a selective bisoxazole alkylation as the key fragment coupling Heterocycles. 57: 1219-1225.  1
2001 Balskus EP, Méndez-Andino J, Arbit RM, Paquette LA. Intercalation of multiple carbon atoms between the carbonyls of alpha-diketones. The Journal of Organic Chemistry. 66: 6695-704. PMID 11578223 DOI: 10.1021/jo010494y  1
2001 Roubeau O, Alcazar Gomez JM, Balskus E, Kolnaar JJA, Haasnoot JG, Reedijk J. Spin-transition behaviour in chains of FeII bridged by 4-substituted 1,2,4-triazoles carrying alkyl tails New Journal of Chemistry. 25: 144-150. DOI: 10.1039/b007094g  1
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