Jennifer A. Doudna - Publications

University of California, Berkeley, Berkeley, CA 
molecular structure of RNA enzymes (ribozymes)

303 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, ... ... Doudna JA, et al. The NIH Somatic Cell Genome Editing program. Nature. 592: 195-204. PMID 33828315 DOI: 10.1038/s41586-021-03191-1  1
2021 Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, de León Derby MD, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, ... ... Doudna JA, et al. Accelerated RNA detection using tandem CRISPR nucleases. Medrxiv : the Preprint Server For Health Sciences. PMID 33791736 DOI: 10.1101/2021.03.19.21253328  1
2021 Amen AM, Fellmann C, Soczek KM, Ren SM, Lew RJ, Knott GJ, Park JE, McKinney AM, Mancini A, Doudna JA, Costello JF. Cancer-specific loss of activation sensitizes glioblastoma to DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33758097 DOI: 10.1073/pnas.2008772118  1
2021 Boyle EA, Becker WR, Bai HB, Chen JS, Doudna JA, Greenleaf WJ. Quantification of Cas9 binding and cleavage across diverse guide sequences maps landscapes of target engagement. Science Advances. 7. PMID 33608277 DOI: 10.1126/sciadv.abe5496  1
2021 Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 184: 844. PMID 33545038 DOI: 10.1016/j.cell.2021.01.019  1
2021 He C, Keren R, Whittaker ML, Farag IF, Doudna JA, Cate JHD, Banfield JF. Genome-resolved metagenomics reveals site-specific diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems. Nature Microbiology. PMID 33495623 DOI: 10.1038/s41564-020-00840-5  1
2021 Shivram H, Cress BF, Knott GJ, Doudna JA. Controlling and enhancing CRISPR systems. Nature Chemical Biology. 17: 10-19. PMID 33328654 DOI: 10.1038/s41589-020-00700-7  0.68
2020 Agrawal S, Fanton A, Chandrasekaran SS, Prywes N, Lukarska M, Biering SB, Smock DCJ, Mok A, Knott GJ, Van E, Dugan E, Kim S, Liu TY, Harris E, Stanley SA, ... ... Doudna JA, et al. Rapid detection of SARS-CoV-2 with Cas13. Medrxiv : the Preprint Server For Health Sciences. PMID 33354689 DOI: 10.1101/2020.12.14.20247874  1
2020 Noureddine A, Maestas-Olguin A, Saada EA, LaBauve AE, Agola JO, Baty KE, Howard T, Sabo JK, Espinoza CRS, Doudna JA, Schoeniger JS, Butler KS, Negrete OA, Brinker CJ, Serda RE. Corrigendum to "Engineering of monosized lipid-coated mesoporous silica nanoparticles for CRISPR delivery" Acta Biomaterialia (2020), 114, 358-368. Acta Biomaterialia. PMID 33309186 DOI: 10.1016/j.actbio.2020.11.038  0.72
2020 Fozouni P, Son S, Díaz de León Derby M, Knott GJ, Gray CN, D'Ambrosio MV, Zhao C, Switz NA, Kumar GR, Stephens SI, Boehm D, Tsou CL, Shu J, Bhuiya A, Armstrong M, ... ... Doudna JA, et al. Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy. Cell. PMID 33306959 DOI: 10.1016/j.cell.2020.12.001  0.68
2020 Angrist M, Barrangou R, Baylis F, Brokowski C, Burgio G, Caplan A, Chapman CR, Church GM, Cook-Deegan R, Cwik B, Doudna JA, Evans JH, Greely HT, Hercher L, Hurlbut JB, et al. Reactions to the National Academies/Royal Society Report on . The Crispr Journal. 3: 332-349. PMID 33095048 DOI: 10.1089/  1
2020 Jones SK, Hawkins JA, Johnson NV, Jung C, Hu K, Rybarski JR, Chen JS, Doudna JA, Press WH, Finkelstein IJ. Massively parallel kinetic profiling of natural and engineered CRISPR nucleases. Nature Biotechnology. PMID 32895548 DOI: 10.1038/S41587-020-0646-5  1
2020 Liu TY, Doudna JA. Chemistry of Class 1 CRISPR-Cas effectors: binding, editing, and regulation. The Journal of Biological Chemistry. PMID 32817336 DOI: 10.1074/Jbc.Rev120.007034  1
2020 Lapinaite A, Knott GJ, Palumbo CM, Lin-Shiao E, Richter MF, Zhao KT, Beal PA, Liu DR, Doudna JA. DNA capture by a CRISPR-Cas9-guided adenine base editor. Science (New York, N.Y.). 369: 566-571. PMID 32732424 DOI: 10.1126/Science.Abb1390  1
2020 Noureddine A, Maestas-Olguin A, Saada EA, LaBauve AE, Agola JO, Baty KE, Howard T, Sabo JK, Espinoza CRS, Doudna JA, Schoeniger JS, Butler KS, Negrete OA, Brinker CJ, Serda RE. Engineering of Monosized Lipid-Coated Mesoporous Silica Nanoparticles for CRISPR Delivery. Acta Biomaterialia. PMID 32702530 DOI: 10.1016/J.Actbio.2020.07.027  0.72
2020 Pausch P, Al-Shayeb B, Bisom-Rapp E, Tsuchida CA, Li Z, Cress BF, Knott GJ, Jacobsen SE, Banfield JF, Doudna JA. CRISPR-CasΦ from huge phages is a hypercompact genome editor. Science (New York, N.Y.). 369: 333-337. PMID 32675376 DOI: 10.1126/Science.Abb1400  0.68
2020 Harrington LB, Ma E, Chen JS, Witte IP, Gertz D, Paez-Espino D, Al-Shayeb B, Kyrpides NC, Burstein D, Banfield JF, Doudna JA. A scoutRNA Is Required for Some Type V CRISPR-Cas Systems. Molecular Cell. PMID 32645367 DOI: 10.1016/J.Molcel.2020.06.022  1
2020 Richter MF, Zhao KT, Eton E, Lapinaite A, Newby GA, Thuronyi BW, Wilson C, Koblan LW, Zeng J, Bauer DE, Doudna JA, Liu DR. Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity. Nature Biotechnology. PMID 32433548 DOI: 10.1038/S41587-020-0562-8  1
2020 Richter MF, Zhao KT, Eton E, Lapinaite A, Newby GA, Thuronyi BW, Wilson C, Koblan LW, Zeng J, Bauer DE, Doudna JA, Liu DR. Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity. Nature Biotechnology. PMID 32433547 DOI: 10.1038/S41587-020-0453-Z  1
2020 Eitzinger S, Asif A, Watters KE, Iavarone AT, Knott GJ, Doudna JA, Minhas FUAA. Machine learning predicts new anti-CRISPR proteins. Nucleic Acids Research. PMID 32286628 DOI: 10.1093/Nar/Gkaa219  0.68
2020 Watters KE, Shivram H, Fellmann C, Lew RJ, McMahon B, Doudna JA. Potent CRISPR-Cas9 inhibitors from genomes. Proceedings of the National Academy of Sciences of the United States of America. PMID 32156733 DOI: 10.1073/Pnas.1917668117  1
2020 Ivanov IE, Wright AV, Cofsky JC, Aris KDP, Doudna JA, Bryant Z. Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling. Proceedings of the National Academy of Sciences of the United States of America. PMID 32123105 DOI: 10.1073/Pnas.1913445117  1
2020 Al-Shayeb B, Sachdeva R, Chen LX, Ward F, Munk P, Devoto A, Castelle CJ, Olm MR, Bouma-Gregson K, Amano Y, He C, Méheust R, Brooks B, Thomas A, Lavy A, ... ... Doudna JA, et al. Clades of huge phages from across Earth's ecosystems. Nature. PMID 32051592 DOI: 10.1038/S41586-020-2007-4  1
2019 Cao Y, Ma E, Cestellos-Blanco S, Qiu R, Su Y, Doudna JA, Yang P. Reply to Nathamgari et al.: Nanopore electroporation for intracellular delivery of biological macromolecules. Proceedings of the National Academy of Sciences of the United States of America. PMID 31662468 DOI: 10.1073/Pnas.1912715116  1
2019 Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA. Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a. Elife. 8. PMID 31397669 DOI: 10.7554/Elife.49110  1
2019 Liu TY, Liu JJ, Aditham AJ, Nogales E, Doudna JA. Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble. Nature Communications. 10: 3001. PMID 31278272 DOI: 10.1038/S41467-019-10780-2  1
2019 Thavalingam A, Cheng Z, Garcia B, Huang X, Shah M, Sun W, Wang M, Harrington L, Hwang S, Hidalgo-Reyes Y, Sontheimer EJ, Doudna J, Davidson AR, Moraes TF, Wang Y, et al. Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. Nature Communications. 10: 2806. PMID 31243272 DOI: 10.1038/S41467-019-10577-3  1
2019 Chen LX, Al-Shayeb B, Méheust R, Li WJ, Doudna JA, Banfield JF. Candidate Phyla Radiation Roizmanbacteria From Hot Springs Have Novel and Unexpectedly Abundant CRISPR-Cas Systems. Frontiers in Microbiology. 10: 928. PMID 31130929 DOI: 10.3389/Fmicb.2019.00928  0.4
2019 Kundert K, Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T. Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs. Nature Communications. 10: 2127. PMID 31073154 DOI: 10.1038/S41467-019-09985-2  1
2019 Ricci CG, Chen JS, Miao Y, Jinek M, Doudna JA, McCammon JA, Palermo G. Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics. Acs Central Science. 5: 651-662. PMID 31041385 DOI: 10.1021/Acscentsci.9B00020  1
2019 Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knott GJ, Harrington LB, Al-Shayeb B, Wagner A, Brötzmann J, Staahl BT, Taylor KL, ... ... Doudna JA, et al. Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors. Nature. PMID 30944483 DOI: 10.1038/S41586-019-1084-8  1
2019 Cao Y, Ma E, Cestellos-Blanco S, Zhang B, Qiu R, Su Y, Doudna JA, Yang P. Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules. Proceedings of the National Academy of Sciences of the United States of America. PMID 30923112 DOI: 10.1073/Pnas.1818553116  1
2019 Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knott GJ, Harrington LB, Al-Shayeb B, Wagner A, Brötzmann J, Staahl BT, Taylor KL, ... ... Doudna JA, et al. CasX enzymes comprise a distinct family of RNA-guided genome editors. Nature. PMID 30718774 DOI: 10.1038/S41586-019-0908-X  1
2019 Heler R, Wright AV, Vucelja M, Doudna JA, Marraffini LA. Spacer Acquisition Rates Determine the Immunological Diversity of the Type II CRISPR-Cas Immune Response. Cell Host & Microbe. PMID 30709780 DOI: 10.1016/J.Chom.2018.12.016  1
2019 Wright AV, Wang JY, Burstein D, Harrington LB, Paez-Espino D, Kyrpides NC, Iavarone AT, Banfield JF, Doudna JA. A Functional Mini-Integrase in a Two-Protein-type V-C CRISPR System. Molecular Cell. PMID 30709710 DOI: 10.1016/J.Molcel.2018.12.015  1
2019 Oakes BL, Fellmann C, Rishi H, Taylor KL, Ren SM, Nadler DC, Yokoo R, Arkin AP, Doudna JA, Savage DF. CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification. Cell. 176: 254-267.e16. PMID 30633905 DOI: 10.1016/J.Cell.2018.11.052  1
2018 Bondy-Denomy J, Davidson AR, Doudna JA, Fineran PC, Maxwell KL, Moineau S, Peng X, Sontheimer EJ, Wiedenheft B. A Unified Resource for Tracking Anti-CRISPR Names. The Crispr Journal. 1: 304-305. PMID 31021273 DOI: 10.1089/crispr.2018.0043  1
2018 Palermo G, Chen JS, Ricci CG, Rivalta I, Jinek M, Batista VS, Doudna JA, McCammon JA. Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain. Quarterly Reviews of Biophysics. 51: e9. PMID 30912489 DOI: 10.1017/S0033583518000070  1
2018 Jiang F, Liu JJ, Osuna BA, Xu M, Berry JD, Rauch BJ, Nogales E, Bondy-Denomy J, Doudna JA. Temperature-Responsive Competitive Inhibition of CRISPR-Cas9. Molecular Cell. PMID 30595438 DOI: 10.2210/Pdb6Mcc/Pdb  1
2018 Palermo G, Chen JS, Ricci CG, Rivalta I, Jinek M, Batista VS, Doudna JA, McCammon JA. Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain. Quarterly Reviews of Biophysics. 51. PMID 30555184 DOI: 10.1017/S0033583518000070  1
2018 Harrington LB, Burstein D, Chen JS, Paez-Espino D, Ma E, Witte IP, Cofsky JC, Kyrpides NC, Banfield JF, Doudna JA. Programmed DNA destruction by miniature CRISPR-Cas14 enzymes. Science (New York, N.Y.). PMID 30337455 DOI: 10.1126/Science.Aav4294  1
2018 Mancini A, Xavier-Magalhães A, Woods WS, Nguyen KT, Amen AM, Hayes JL, Fellmann C, Gapinske M, McKinney AM, Hong C, Jones LE, Walsh KM, Bell RJA, Doudna JA, Costa BM, et al. Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner. Cancer Cell. 34: 513-528.e8. PMID 30205050 DOI: 10.1016/J.Ccell.2018.08.003  1
2018 Watters KE, Fellmann C, Bai HB, Ren SM, Doudna JA. Systematic discovery of natural CRISPR-Cas12a inhibitors. Science (New York, N.Y.). PMID 30190307 DOI: 10.1126/Science.Aau5138  1
2018 Knott GJ, Doudna JA. CRISPR-Cas guides the future of genetic engineering. Science (New York, N.Y.). 361: 866-869. PMID 30166482 DOI: 10.1126/Science.Aat5011  0.68
2018 Tambe A, East-Seletsky A, Knott GJ, Doudna JA, O'Connell MR. RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a. Cell Reports. 24: 1025-1036. PMID 30044970 DOI: 10.1016/J.Celrep.2018.06.105  1
2018 Huang CH, Lee KC, Doudna JA. Applications of CRISPR-Cas Enzymes in Cancer Therapeutics and Detection. Trends in Cancer. 4: 499-512. PMID 29937048 DOI: 10.1016/j.trecan.2018.05.006  0.36
2018 Rouet R, Thuma BA, Roy MD, Lintner NG, Rubitski DM, Finley JE, Wisniewska HM, Mendonsa R, Hirsh A, de Oñate L, Compte J, Mclellan TJ, Bellenger J, Feng X, Varghese A, ... ... Doudna JA, et al. Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell Type Specific Gene Editing. Journal of the American Chemical Society. PMID 29668265 DOI: 10.1021/Jacs.8B01551  1
2018 Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, et al. Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. Plos Biology. 16: e1002628. PMID 29664898 DOI: 10.1371/journal.pbio.1002628  1
2018 Lapinaite A, Doudna JA, Cate JHD. Programmable RNA recognition using a CRISPR-associated Argonaute. Proceedings of the National Academy of Sciences of the United States of America. PMID 29531059 DOI: 10.1073/Pnas.1717725115  1
2018 Chen JS, Ma E, Harrington LB, Da Costa M, Tian X, Palefsky JM, Doudna JA. CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity. Science (New York, N.Y.). PMID 29449511 DOI: 10.1126/Science.Aar6245  1
2018 Kiessling LL, Doudna JA. Spotlight: A Conversation with Laura Kiessling and Jennifer Doudna. Acs Chemical Biology. 13: 290-295. PMID 29448761 DOI: 10.1021/Acschembio.8B00108  1
2018 Strutt SC, Torrez RM, Kaya E, Negrete OA, Doudna JA. RNA-dependent RNA targeting by CRISPR-Cas9. Elife. 7. PMID 29303478 DOI: 10.7554/Elife.32724  1
2017 Lee K, Conboy M, Park HM, Jiang F, Kim HJ, Dewitt MA, Mackley VA, Chang K, Rao A, Skinner C, Shobha T, Mehdipour M, Liu H, Huang WC, Lan F, ... ... Doudna JA, et al. Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA induces homology-directed DNA repair. Nature Biomedical Engineering. 1: 889-901. PMID 29805845 DOI: 10.1038/S41551-017-0137-2  1
2017 Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN. Widespread Translational Remodeling during Human Neuronal Differentiation. Cell Reports. 21: 2005-2016. PMID 29141229 DOI: 10.1016/J.Celrep.2017.10.095  1
2017 Harrington LB, Paez-Espino D, Staahl BT, Chen JS, Ma E, Kyrpides NC, Doudna JA. A thermostable Cas9 with increased lifetime in human plasma. Nature Communications. 8: 1424. PMID 29127284 DOI: 10.1038/S41467-017-01408-4  1
2017 Chen JS, Dagdas YS, Kleinstiver BP, Welch MM, Sousa AA, Harrington LB, Sternberg SH, Joung JK, Yildiz A, Doudna JA. Enhanced proofreading governs CRISPR-Cas9 targeting accuracy. Nature. PMID 28931002 DOI: 10.1016/J.Bpj.2017.11.1082  1
2017 Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA. Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme. Nature Structural & Molecular Biology. PMID 28892041 DOI: 10.1038/Nsmb.3466  1
2017 Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell. PMID 28844692 DOI: 10.1016/J.Cell.2017.07.037  1
2017 Dagdas YS, Chen JS, Sternberg SH, Doudna JA, Yildiz A. A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9. Science Advances. 3: eaao0027. PMID 28808686 DOI: 10.1126/Sciadv.Aao0027  1
2017 Wright AV, Liu JJ, Knott GJ, Doxzen KW, Nogales E, Doudna JA. Structures of the CRISPR genome integration complex. Science (New York, N.Y.). PMID 28729350 DOI: 10.1126/Science.Aao0679  1
2017 Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA. Disabling Cas9 by an anti-CRISPR DNA mimic. Science Advances. 3: e1701620. PMID 28706995 DOI: 10.1126/Sciadv.1701620  1
2017 Doxzen KW, Doudna JA. DNA recognition by an RNA-guided bacterial Argonaute. Plos One. 12: e0177097. PMID 28520746 DOI: 10.1371/Journal.Pone.0177097  0.72
2017 Boyle EA, Andreasson JOL, Chircus LM, Sternberg SH, Wu MJ, Guegler CK, Doudna JA, Greenleaf WJ. High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding. Proceedings of the National Academy of Sciences of the United States of America. PMID 28495970 DOI: 10.1073/Pnas.1700557114  1
2017 East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA. RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes. Molecular Cell. 66: 373-383.e3. PMID 28475872 DOI: 10.1016/J.Molcel.2017.04.008  1
2017 Liu TY, Iavarone AT, Doudna JA. Correction: RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System. Plos One. 12: e0175612. PMID 28384323 DOI: 10.1371/Journal.Pone.0175612  1
2017 Jiang F, Doudna JA. CRISPR-Cas9 Structures and Mechanisms. Annual Review of Biophysics. PMID 28375731 DOI: 10.1146/Annurev-Biophys-062215-010822  1
2017 Gaj T, Staahl BT, Rodrigues GM, Limsirichai P, Ekman FK, Doudna JA, Schaffer DV. Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery. Nucleic Acids Research. PMID 28334779 DOI: 10.1093/Nar/Gkx154  1
2017 Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. Plos Biology. 15: e2001882. PMID 28323820 DOI: 10.1371/Journal.Pbio.2001882  1
2017 Staahl BT, Benekareddy M, Coulon-Bainier C, Banfal AA, Floor SN, Sabo JK, Urnes C, Munares GA, Ghosh A, Doudna JA. Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes. Nature Biotechnology. PMID 28191903 DOI: 10.1038/Nbt.3806  1
2017 Liu TY, Iavarone AT, Doudna JA. RNA and DNA Targeting by a Reconstituted Thermus thermophiles Type III-A CRISPR-Cas System. Plos One. 12: e0170552. PMID 28114398 DOI: 10.1371/Journal.Pone.0170552  1
2016 Heler R, Wright AV, Vucelja M, Bikard D, Doudna JA, Marraffini LA. Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response. Molecular Cell. PMID 28017588 DOI: 10.1016/J.Molcel.2016.11.031  1
2016 Fellmann C, Gowen BG, Lin PC, Doudna JA, Corn JE. Cornerstones of CRISPR-Cas in drug discovery and therapy. Nature Reviews. Drug Discovery. PMID 28008168 DOI: 10.1038/Nrd.2016.238  1
2016 Burstein D, Harrington LB, Strutt SC, Probst AJ, Anantharaman K, Thomas BC, Doudna JA, Banfield JF. New CRISPR-Cas systems from uncultivated microbes. Nature. PMID 28005056 DOI: 10.1038/Nature21059  1
2016 Koh HR, Kidwell MA, Doudna JA, Myong S. RNA scanning of a molecular machine with a built-in ruler. Journal of the American Chemical Society. PMID 27958730 DOI: 10.1021/Jacs.6B10387  1
2016 East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate JH, Tjian R, Doudna JA. Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection. Nature. PMID 27669025 DOI: 10.1038/Nature19802  1
2016 Singh D, Sternberg SH, Fei J, Doudna JA, Ha T. Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9. Nature Communications. 7: 12778. PMID 27624851 DOI: 10.1038/Ncomms12778  1
2016 Barrangou R, Doudna JA. Applications of CRISPR technologies in research and beyond. Nature Biotechnology. 34: 933-941. PMID 27606440 DOI: 10.1038/Nbt.3659  0.01
2016 Wright AV, Doudna JA. Protecting genome integrity during CRISPR immune adaptation. Nature Structural & Molecular Biology. PMID 27595346 DOI: 10.1038/Nsmb.3289  1
2016 Hochstrasser ML, Taylor DW, Kornfeld JE, Nogales E, Doudna JA. DNA Targeting by a Minimal CRISPR RNA-Guided Cascade. Molecular Cell. 63: 840-51. PMID 27588603 DOI: 10.1016/J.Molcel.2016.07.027  1
2016 Lee AS, Kranzusch PJ, Doudna JA, Cate JH. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature. 536: 96-9. PMID 27462815 DOI: 10.1038/Nature18954  1
2016 Carlson LA, Bai Y, Keane SC, Doudna JA, Hurley JH. Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies. Elife. 5. PMID 27343348 DOI: 10.7554/Elife.14663  1
2016 Nuñez JK, Bai L, Harrington LB, Hinder TL, Doudna JA. CRISPR Immunological Memory Requires a Host Factor for Specificity. Molecular Cell. 62: 824-33. PMID 27211867 DOI: 10.1016/J.Molcel.2016.04.027  1
2016 Oakes BL, Nadler DC, Flamholz A, Fellmann C, Staahl BT, Doudna JA, Savage DF. Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch. Nature Biotechnology. 34: 646-51. PMID 27136077 DOI: 10.1038/Nbt.3528  1
2016 Isaac RS, Jiang F, Doudna JA, Lim WA, Narlikar GJ, Almeida R. Nucleosome breathing and remodeling constrain CRISPR-Cas9 function. Elife. 5. PMID 27130520 DOI: 10.7554/Elife.13450  1
2016 Oh S, Flynn RA, Floor SN, Purzner J, Martin L, Do BT, Schubert S, Vaka D, Morrissy S, Li Y, Kool M, Hovestadt V, Jones DT, Northcott PA, Risch T, ... ... Doudna JA, et al. Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress. Oncotarget. 7: 28169-82. PMID 27058758 DOI: 10.18632/Oncotarget.8612  1
2016 Kaya E, Doxzen KW, Knoll KR, Wilson RC, Strutt SC, Kranzusch PJ, Doudna JA. A bacterial Argonaute with noncanonical guide RNA specificity. Proceedings of the National Academy of Sciences of the United States of America. 113: 4057-62. PMID 27035975 DOI: 10.1073/Pnas.1524385113  1
2016 Nelles DA, Fang MY, O'Connell MR, Xu JL, Markmiller SJ, Doudna JA, Yeo GW. Programmable RNA Tracking in Live Cells with CRISPR/Cas9. Cell. 165: 488-96. PMID 26997482 DOI: 10.1016/J.Cell.2016.02.054  1
2016 Nuñez JK, Harrington LB, Doudna JA. Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering. Acs Chemical Biology. 11: 681-8. PMID 26857072 DOI: 10.1021/Acschembio.5B01019  1
2016 Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA. Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage. Science (New York, N.Y.). 351: 867-71. PMID 26841432 DOI: 10.1126/Science.Aad8282  1
2016 Wright AV, Nuñez JK, Doudna JA. Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering. Cell. 164: 29-44. PMID 26771484 DOI: 10.1016/J.Cell.2015.12.035  1
2016 Floor SN, Doudna JA. Tunable protein synthesis by transcript isoforms in human cells. Elife. 5. PMID 26735365 DOI: 10.7554/Elife.10921  1
2016 Floor SN, Barkovich KJ, Condon KJ, Shokat KM, Doudna JA. Analog sensitive chemical inhibition of the DEAD-box protein DDX3. Protein Science : a Publication of the Protein Society. 25: 638-49. PMID 26650549 DOI: 10.1002/Pro.2857  1
2016 Floor SN, Condon KJ, Sharma D, Jankowsky E, Doudna JA. Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3. The Journal of Biological Chemistry. 291: 2412-21. PMID 26598523 DOI: 10.1074/Jbc.M115.700625  1
2015 Doudna J. Genome-editing revolution: My whirlwind year with CRISPR Nature. 528: 469-471. PMID 26701037 DOI: 10.1038/528469A  1
2015 Doudna JA, Gersbach CA. Genome editing: the end of the beginning. Genome Biology. 16: 292. PMID 26700220 DOI: 10.1186/S13059-015-0860-5  0.01
2015 Floor SN, Doudna JA. Get in LINE: Competition for Newly Minted Retrotransposon Proteins at the Ribosome. Molecular Cell. 60: 712-4. PMID 26638173 DOI: 10.1016/J.Molcel.2015.11.014  1
2015 Doudna J. Perspective: Embryo editing needs scrutiny Nature. 528: S6. PMID 26630598 DOI: 10.1038/528S6A  1
2015 Knight SC, Xie L, Deng W, Guglielmi B, Witkowsky LB, Bosanac L, Zhang ET, El Beheiry M, Masson JB, Dahan M, Liu Z, Doudna JA, Tjian R. Dynamics of CRISPR-Cas9 genome interrogation in living cells. Science (New York, N.Y.). 350: 823-6. PMID 26564855 DOI: 10.1126/Science.Aac6572  0.48
2015 Ma E, Harrington LB, O'Connell MR, Zhou K, Doudna JA. Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes. Molecular Cell. 60: 398-407. PMID 26545076 DOI: 10.1016/J.Molcel.2015.10.030  1
2015 Sternberg SH, LaFrance B, Kaplan M, Doudna JA. Conformational control of DNA target cleavage by CRISPR-Cas9. Nature. 527: 110-3. PMID 26524520 DOI: 10.1038/Nature15544  1
2015 Redding S, Sternberg SH, Marshall M, Gibb B, Bhat P, Guegler CK, Wiedenheft B, Doudna JA, Greene EC. Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System. Cell. 163: 854-65. PMID 26522594 DOI: 10.1016/J.Cell.2015.10.003  1
2015 Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA. Foreign DNA capture during CRISPR-Cas adaptive immunity. Nature. 527: 535-8. PMID 26503043 DOI: 10.1038/Nature15760  1
2015 Kranzusch PJ, Wilson SC, Lee AS, Berger JM, Doudna JA, Vance RE. Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Molecular Cell. 59: 891-903. PMID 26300263 DOI: 10.1016/J.Molcel.2015.07.022  1
2015 Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA, Marson A. Generation of knock-in primary human T cells using Cas9 ribonucleoproteins. Proceedings of the National Academy of Sciences of the United States of America. 112: 10437-42. PMID 26216948 DOI: 10.1073/Pnas.1512503112  1
2015 Jiang F, Zhou K, Ma L, Gressel S, Doudna JA. STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition. Science (New York, N.Y.). 348: 1477-81. PMID 26113724 DOI: 10.1126/Science.Aab1452  1
2015 Sternberg SH, Doudna JA. Expanding the Biologist's Toolkit with CRISPR-Cas9. Molecular Cell. 58: 568-74. PMID 26000842 DOI: 10.1016/J.Molcel.2015.02.032  1
2015 Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W, Kim JS, Knoppers B, et al. CRISPR germline engineering--the community speaks. Nature Biotechnology. 33: 478-86. PMID 25965754 DOI: 10.1038/Nbt.3227  1
2015 Taylor DW, Zhu Y, Staals RH, Kornfeld JE, Shinkai A, van der Oost J, Nogales E, Doudna JA. Structural biology. Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning. Science (New York, N.Y.). 348: 581-5. PMID 25837515 DOI: 10.1126/Science.Aaa4535  1
2015 Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, et al. Biotechnology. A prudent path forward for genomic engineering and germline gene modification. Science (New York, N.Y.). 348: 36-8. PMID 25791083 DOI: 10.1126/Science.Aab1028  1
2015 Jiang F, Doudna JA. The structural biology of CRISPR-Cas systems. Current Opinion in Structural Biology. 30: 100-11. PMID 25723899 DOI: 10.1016/J.Sbi.2015.02.002  1
2015 Wright AV, Sternberg SH, Taylor DW, Staahl BT, Bardales JA, Kornfeld JE, Doudna JA. Rational design of a split-Cas9 enzyme complex. Proceedings of the National Academy of Sciences of the United States of America. 112: 2984-9. PMID 25713377 DOI: 10.1073/Pnas.1501698112  1
2015 Doudna JA. Genomic engineering and the future of medicine. Jama. 313: 791-2. PMID 25710652 DOI: 10.1001/Jama.2015.287  0.01
2015 Nuñez JK, Lee AS, Engelman A, Doudna JA. Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity. Nature. 519: 193-8. PMID 25707795 DOI: 10.1038/Nature14237  1
2015 Wilson RC, Tambe A, Kidwell MA, Noland CL, Schneider CP, Doudna JA. Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis. Molecular Cell. 57: 397-407. PMID 25557550 DOI: 10.1016/J.Molcel.2014.11.030  1
2015 Hochstrasser ML, Doudna JA. Cutting it close: CRISPR-associated endoribonuclease structure and function. Trends in Biochemical Sciences. 40: 58-66. PMID 25468820 DOI: 10.1016/J.Tibs.2014.10.007  1
2014 Lin S, Staahl BT, Alla RK, Doudna JA. Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery. Elife. 3: e04766. PMID 25497837 DOI: 10.7554/Elife.04766  1
2014 Staals RH, Zhu Y, Taylor DW, Kornfeld JE, Sharma K, Barendregt A, Koehorst JJ, Vlot M, Neupane N, Varossieau K, Sakamoto K, Suzuki T, Dohmae N, Yokoyama S, Schaap PJ, ... ... Doudna JA, et al. RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus. Molecular Cell. 56: 518-30. PMID 25457165 DOI: 10.1016/J.Molcel.2014.10.005  1
2014 Doudna JA, Charpentier E. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science (New York, N.Y.). 346: 1258096. PMID 25430774 DOI: 10.1126/Science.1258096  1
2014 Doudna JA, Sontheimer EJ. Methods in Enzymology. The use of CRISPR/Cas9, ZFNs, and TALENs in generating site-specific genome alterations. Preface. Methods in Enzymology. 546: xix-xx. PMID 25398356 DOI: 10.1016/B978-0-12-801185-0.09983-9  0.44
2014 Kapral GJ, Jain S, Noeske J, Doudna JA, Richardson DC, Richardson JS. New tools provide a second look at HDV ribozyme structure, dynamics and cleavage. Nucleic Acids Research. 42: 12833-46. PMID 25326328 DOI: 10.1093/Nar/Gku992  1
2014 O'Connell MR, Oakes BL, Sternberg SH, East-Seletsky A, Kaplan M, Doudna JA. Programmable RNA recognition and cleavage by CRISPR/Cas9. Nature. 516: 263-6. PMID 25274302 DOI: 10.1038/Nature13769  1
2014 Bai Y, Tambe A, Zhou K, Doudna JA. RNA-guided assembly of Rev-RRE nuclear export complexes. Elife. 3: e03656. PMID 25163983 DOI: 10.7554/Elife.03656  1
2014 Kidwell MA, Chan JM, Doudna JA. Evolutionarily conserved roles of the dicer helicase domain in regulating RNA interference processing. The Journal of Biological Chemistry. 289: 28352-62. PMID 25135636 DOI: 10.1074/Jbc.M114.589051  1
2014 Kranzusch PJ, Lee AS, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA. Structure-guided reprogramming of human cGAS dinucleotide linkage specificity. Cell. 158: 1011-21. PMID 25131990 DOI: 10.1016/J.Cell.2014.07.028  1
2014 Mortimer SA, Kidwell MA, Doudna JA. Insights into RNA structure and function from genome-wide studies. Nature Reviews. Genetics. 15: 469-79. PMID 24821474 DOI: 10.1038/Nrg3681  1
2014 Nuñez JK, Kranzusch PJ, Noeske J, Wright AV, Davies CW, Doudna JA. Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity. Nature Structural & Molecular Biology. 21: 528-34. PMID 24793649 DOI: 10.1038/Nsmb.2820  1
2014 Hochstrasser ML, Taylor DW, Bhat P, Guegler CK, Sternberg SH, Nogales E, Doudna JA. CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference. Proceedings of the National Academy of Sciences of the United States of America. 111: 6618-23. PMID 24748111 DOI: 10.1073/Pnas.1405079111  1
2014 Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA. Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science (New York, N.Y.). 343: 1247997. PMID 24505130 DOI: 10.1126/Science.1247997  1
2014 Sternberg SH, Redding S, Jinek M, Greene EC, Doudna JA. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature. 507: 62-7. PMID 24476820 DOI: 10.1038/Nature13011  1
2014 Niewoehner O, Jinek M, Doudna JA. Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases. Nucleic Acids Research. 42: 1341-53. PMID 24150936 DOI: 10.1093/Nar/Gkt922  1
2013 Staals RH, Agari Y, Maki-Yonekura S, Zhu Y, Taylor DW, van Duijn E, Barendregt A, Vlot M, Koehorst JJ, Sakamoto K, Masuda A, Dohmae N, Schaap PJ, Doudna JA, Heck AJ, et al. Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus. Molecular Cell. 52: 135-45. PMID 24119403 DOI: 10.1016/J.Molcel.2013.09.013  1
2013 Cox EM, Sagan SM, Mortimer SA, Doudna JA, Sarnow P. Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules. Rna (New York, N.Y.). 19: 1825-32. PMID 24106328 DOI: 10.1261/Rna.040865.113  1
2013 Kidwell MA, Doudna JA. Activating silent argonautes. Nature Structural & Molecular Biology. 20: 769-71. PMID 23984440 DOI: 10.1038/Nsmb.2620  1
2013 Lo TW, Pickle CS, Lin S, Ralston EJ, Gurling M, Schartner CM, Bian Q, Doudna JA, Meyer BJ. Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions. Genetics. 195: 331-48. PMID 23934893 DOI: 10.1534/Genetics.113.155382  1
2013 Pattanayak V, Lin S, Guilinger JP, Ma E, Doudna JA, Liu DR. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nature Biotechnology. 31: 839-43. PMID 23934178 DOI: 10.1038/Nbt.2673  1
2013 Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 154: 442-51. PMID 23849981 DOI: 10.1016/J.Cell.2013.06.044  1
2013 Bai Y, Zhou K, Doudna JA. Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. Nucleic Acids Research. 41: 7861-74. PMID 23783572 DOI: 10.1093/Nar/Gkt543  1
2013 Sun C, Querol-Audí J, Mortimer SA, Arias-Palomo E, Doudna JA, Nogales E, Cate JH. Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. Nucleic Acids Research. 41: 7512-21. PMID 23766293 DOI: 10.1093/Nar/Gkt510  1
2013 Kranzusch PJ, Lee AS, Berger JM, Doudna JA. Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Reports. 3: 1362-8. PMID 23707061 DOI: 10.1016/J.Celrep.2013.05.008  1
2013 Lee HY, Zhou K, Smith AM, Noland CL, Doudna JA. Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing. Nucleic Acids Research. 41: 6568-76. PMID 23661684 DOI: 10.1093/Nar/Gkt361  1
2013 Wilson RC, Doudna JA. Molecular mechanisms of RNA interference. Annual Review of Biophysics. 42: 217-39. PMID 23654304 DOI: 10.1146/Annurev-Biophys-083012-130404  1
2013 Taylor DW, Ma E, Shigematsu H, Cianfrocco MA, Noland CL, Nagayama K, Nogales E, Doudna JA, Wang HW. Substrate-specific structural rearrangements of human Dicer. Nature Structural & Molecular Biology. 20: 662-70. PMID 23624860 DOI: 10.1038/Nsmb.2564  1
2013 Noland CL, Doudna JA. Multiple sensors ensure guide strand selection in human RNAi pathways. Rna (New York, N.Y.). 19: 639-48. PMID 23531496 DOI: 10.1261/Rna.037424.112  1
2013 Lee HY, Haurwitz RE, Apffel A, Zhou K, Smart B, Wenger CD, Laderman S, Bruhn L, Doudna JA. RNA-protein analysis using a conditional CRISPR nuclease. Proceedings of the National Academy of Sciences of the United States of America. 110: 5416-21. PMID 23493562 DOI: 10.1073/Pnas.1302807110  1
2013 Charpentier E, Doudna JA. Biotechnology: Rewriting a genome. Nature. 495: 50-1. PMID 23467164 DOI: 10.1038/495050A  1
2013 Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 152: 1173-83. PMID 23452860 DOI: 10.1016/J.Cell.2013.02.022  1
2013 Mortimer SA, Doudna JA. Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure. Nucleic Acids Research. 41: 4230-40. PMID 23416544 DOI: 10.1093/Nar/Gkt075  1
2013 Jinek M, East A, Cheng A, Lin S, Ma E, Doudna J. RNA-programmed genome editing in human cells Elife. 2013. PMID 23386978 DOI: 10.7554/Elife.00471  1
2013 Koh HR, Kidwell MA, Ragunathan K, Doudna JA, Myong S. ATP-independent diffusion of double-stranded RNA binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: 151-6. PMID 23251028 DOI: 10.1073/Pnas.1212917110  1
2012 Lee HY, Doudna JA. TRBP alters human precursor microRNA processing in vitro. Rna (New York, N.Y.). 18: 2012-9. PMID 23006623 DOI: 10.1261/Rna.035501.112  1
2012 Qi L, Haurwitz RE, Shao W, Doudna JA, Arkin AP. RNA processing enables predictable programming of gene expression. Nature Biotechnology. 30: 1002-6. PMID 22983090 DOI: 10.1038/Nbt.2355  1
2012 van Duijn E, Barbu IM, Barendregt A, Jore MM, Wiedenheft B, Lundgren M, Westra ER, Brouns SJ, Doudna JA, van der Oost J, Heck AJ. Native tandem and ion mobility mass spectrometry highlight structural and modular similarities in clustered-regularly-interspaced shot-palindromic-repeats (CRISPR)-associated protein complexes from Escherichia coli and Pseudomonas aeruginosa. Molecular & Cellular Proteomics : McP. 11: 1430-41. PMID 22918228 DOI: 10.1074/Mcp.M112.020263  1
2012 Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science (New York, N.Y.). 337: 816-21. PMID 22745249 DOI: 10.1126/Science.1225829  1
2012 Ma E, Zhou K, Kidwell MA, Doudna JA. Coordinated activities of human dicer domains in regulatory RNA processing. Journal of Molecular Biology. 422: 466-76. PMID 22727743 DOI: 10.1016/J.Jmb.2012.06.009  1
2012 Kaya E, Doudna JA. Biochemistry. Guided tour to the heart of RISC. Science (New York, N.Y.). 336: 985-6. PMID 22628640 DOI: 10.1126/Science.1223549  1
2012 Haurwitz RE, Sternberg SH, Doudna JA. Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA. The Embo Journal. 31: 2824-32. PMID 22522703 DOI: 10.1038/Emboj.2012.107  1
2012 Sashital DG, Wiedenheft B, Doudna JA. Mechanism of foreign DNA selection in a bacterial adaptive immune system. Molecular Cell. 46: 606-15. PMID 22521690 DOI: 10.1016/J.Molcel.2012.03.020  1
2012 Sternberg SH, Haurwitz RE, Doudna JA. Mechanism of substrate selection by a highly specific CRISPR endoribonuclease. Rna (New York, N.Y.). 18: 661-72. PMID 22345129 DOI: 10.1261/Rna.030882.111  1
2012 Wiedenheft B, Sternberg SH, Doudna JA. RNA-guided genetic silencing systems in bacteria and archaea. Nature. 482: 331-8. PMID 22337052 DOI: 10.1038/Nature10886  1
2012 Mehle A, Dugan VG, Taubenberger JK, Doudna JA. Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers. Journal of Virology. 86: 1750-7. PMID 22090127 DOI: 10.1128/Jvi.06203-11  1
2011 Arribere JA, Doudna JA, Gilbert WV. Reconsidering movement of eukaryotic mRNAs between polysomes and P bodies. Molecular Cell. 44: 745-58. PMID 22152478 DOI: 10.1016/J.Molcel.2011.09.019  1
2011 Sun C, Todorovic A, Querol-Audí J, Bai Y, Villa N, Snyder M, Ashchyan J, Lewis CS, Hartland A, Gradia S, Fraser CS, Doudna JA, Nogales E, Cate JH. Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3). Proceedings of the National Academy of Sciences of the United States of America. 108: 20473-8. PMID 22135459 DOI: 10.1073/Pnas.1116821108  1
2011 Berry KE, Waghray S, Mortimer SA, Bai Y, Doudna JA. Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning. Structure (London, England : 1993). 19: 1456-66. PMID 22000514 DOI: 10.1016/J.Str.2011.08.002  1
2011 Wiedenheft B, Lander GC, Zhou K, Jore MM, Brouns SJ, van der Oost J, Doudna JA, Nogales E. Structures of the RNA-guided surveillance complex from a bacterial immune system. Nature. 477: 486-9. PMID 21938068 DOI: 10.1038/Nature10402  1
2011 Noland CL, Ma E, Doudna JA. siRNA repositioning for guide strand selection by human Dicer complexes. Molecular Cell. 43: 110-21. PMID 21726814 DOI: 10.1016/J.Molcel.2011.05.028  1
2011 Aviran S, Trapnell C, Lucks JB, Mortimer SA, Luo S, Schroth GP, Doudna JA, Arkin AP, Pachter L. Modeling and automation of sequencing-based characterization of RNA structure. Proceedings of the National Academy of Sciences of the United States of America. 108: 11069-74. PMID 21642536 DOI: 10.1073/Pnas.1106541108  1
2011 Lucks JB, Mortimer SA, Trapnell C, Luo S, Aviran S, Schroth GP, Pachter L, Doudna JA, Arkin AP. Multiplexed RNA structure characterization with selective 2'-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq). Proceedings of the National Academy of Sciences of the United States of America. 108: 11063-8. PMID 21642531 DOI: 10.1073/Pnas.1106501108  1
2011 Sashital DG, Jinek M, Doudna JA. An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3. Nature Structural & Molecular Biology. 18: 680-7. PMID 21572442 DOI: 10.1038/Nsmb.2043  1
2011 Wiedenheft B, van Duijn E, Bultema JB, Bultema J, Waghmare SP, Waghmare S, Zhou K, Barendregt A, Westphal W, Heck AJ, Heck A, Boekema EJ, Boekema E, Dickman MJ, Dickman M, ... Doudna JA, et al. RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proceedings of the National Academy of Sciences of the United States of America. 108: 10092-7. PMID 21536913 DOI: 10.1073/Pnas.1102716108  1
2011 Jore MM, Lundgren M, van Duijn E, Bultema JB, Westra ER, Waghmare SP, Wiedenheft B, Pul U, Wurm R, Wagner R, Beijer MR, Barendregt A, Zhou K, Snijders AP, Dickman MJ, ... Doudna JA, et al. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature Structural & Molecular Biology. 18: 529-36. PMID 21460843 DOI: 10.1038/Nsmb.2019  1
2011 Jinek M, Coyle SM, Doudna JA. Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay. Molecular Cell. 41: 600-8. PMID 21362555 DOI: 10.1016/J.Molcel.2011.02.004  1
2011 Ataide SF, Schmitz N, Shen K, Ke A, Shan SO, Doudna JA, Ban N. The crystal structure of the signal recognition particle in complex with its receptor. Science (New York, N.Y.). 331: 881-6. PMID 21330537 DOI: 10.1126/Science.1196473  1
2011 Berry KE, Peng B, Koditek D, Beeman D, Pagratis N, Perry JK, Parrish J, Zhong W, Doudna JA, Shih IH. Optimized high-throughput screen for hepatitis C virus translation inhibitors. Journal of Biomolecular Screening. 16: 211-20. PMID 21297107 DOI: 10.1177/1087057110391665  1
2011 Wiedenheft B, Van Duijn E, Bultema J, Waghmare S, Zhou K, Barendregt A, Westphal W, Heck AJR, Boekema EJ, Dickman MJ, Doudna JA. RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 25 (10092-10097) DOI: 10.1073/pnas.1102716108) Proceedings of the National Academy of Sciences of the United States of America. 108: 15010. DOI: 10.1073/pnas.1111854108  1
2010 Mehle A, Doudna JA. A host of factors regulating influenza virus replication. Viruses. 2: 566-73. PMID 21994648 DOI: 10.3390/V2020566  1
2010 Chakravarthy S, Sternberg SH, Kellenberger CA, Doudna JA. Substrate-specific kinetics of Dicer-catalyzed RNA processing. Journal of Molecular Biology. 404: 392-402. PMID 20932845 DOI: 10.1016/J.Jmb.2010.09.030  1
2010 Weeks AM, Coyle SM, Jinek M, Doudna JA, Chang MC. Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Biochemistry. 49: 9269-79. PMID 20836570 DOI: 10.1021/Bi101102U  1
2010 Haurwitz RE, Jinek M, Wiedenheft B, Zhou K, Doudna JA. Sequence- and structure-specific RNA processing by a CRISPR endonuclease. Science (New York, N.Y.). 329: 1355-8. PMID 20829488 DOI: 10.1126/Science.1192272  1
2010 Berry KE, Waghray S, Doudna JA. The HCV IRES pseudoknot positions the initiation codon on the 40S ribosomal subunit. Rna (New York, N.Y.). 16: 1559-69. PMID 20584896 DOI: 10.1261/Rna.2197210  1
2010 Clarkson BK, Gilbert WV, Doudna JA. Functional overlap between eIF4G isoforms in Saccharomyces cerevisiae. Plos One. 5: e9114. PMID 20161741 DOI: 10.1371/Journal.Pone.0009114  1
2010 Jinek M, Fabian MR, Coyle SM, Sonenberg N, Doudna JA. Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation. Nature Structural & Molecular Biology. 17: 238-40. PMID 20098421 DOI: 10.1038/Nsmb.1768  1
2010 Sashital DG, Doudna JA. Structural insights into RNA interference. Current Opinion in Structural Biology. 20: 90-7. PMID 20053548 DOI: 10.1016/J.Sbi.2009.12.001  1
2009 Mehle A, Doudna JA. Adaptive strategies of the influenza virus polymerase for replication in humans. Proceedings of the National Academy of Sciences of the United States of America. 106: 21312-6. PMID 19995968 DOI: 10.1073/Pnas.0911915106  1
2009 Wang HW, Noland C, Siridechadilok B, Taylor DW, Ma E, Felderer K, Doudna JA, Nogales E. Structural insights into RNA processing by the human RISC-loading complex. Nature Structural & Molecular Biology. 16: 1148-53. PMID 19820710 DOI: 10.1038/Nsmb.1673  1
2009 Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT, Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna JA, Chen CY, Shyu AB, Yates JR, Hannon GJ, Filipowicz W, et al. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Molecular Cell. 35: 868-80. PMID 19716330 DOI: 10.1016/J.Molcel.2009.08.004  1
2009 Wiedenheft B, Zhou K, Jinek M, Coyle SM, Ma W, Doudna JA. Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense. Structure (London, England : 1993). 17: 904-12. PMID 19523907 DOI: 10.1016/J.Str.2009.03.019  1
2009 Fraser CS, Hershey JW, Doudna JA. The pathway of hepatitis C virus mRNA recruitment to the human ribosome. Nature Structural & Molecular Biology. 16: 397-404. PMID 19287397 DOI: 10.1038/Nsmb.1572  1
2009 Fukunaga R, Doudna JA. dsRNA with 5' overhangs contributes to endogenous and antiviral RNA silencing pathways in plants. The Embo Journal. 28: 545-55. PMID 19165150 DOI: 10.1038/emboj.2009.2  1
2009 Jinek M, Doudna JA. A three-dimensional view of the molecular machinery of RNA interference. Nature. 457: 405-12. PMID 19158786 DOI: 10.1038/Nature07755  1
2009 Coyle SM, Gilbert WV, Doudna JA. Direct link between RACK1 function and localization at the ribosome in vivo. Molecular and Cellular Biology. 29: 1626-34. PMID 19114558 DOI: 10.1128/Mcb.01718-08  1
2008 Mehle A, Doudna JA. An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase. Cell Host & Microbe. 4: 111-22. PMID 18692771 DOI: 10.1016/J.Chom.2008.06.007  1
2008 Zhou M, Sandercock AM, Fraser CS, Ridlova G, Stephens E, Schenauer MR, Yokoi-Fong T, Barsky D, Leary JA, Hershey JW, Doudna JA, Robinson CV. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proceedings of the National Academy of Sciences of the United States of America. 105: 18139-44. PMID 18599441 DOI: 10.1073/Pnas.0801313105  1
2008 Puglisi JD, Doudna JA. Nucleic acids and their protein partners. Current Opinion in Structural Biology. 18: 279-81. PMID 18547801 DOI: 10.1016/J.Sbi.2008.05.004  0.48
2008 Ma E, MacRae IJ, Kirsch JF, Doudna JA. Autoinhibition of human dicer by its internal helicase domain. Journal of Molecular Biology. 380: 237-43. PMID 18508075 DOI: 10.1016/J.Jmb.2008.05.005  1
2008 MacRae IJ, Ma E, Zhou M, Robinson CV, Doudna JA. In vitro reconstitution of the human RISC-loading complex. Proceedings of the National Academy of Sciences of the United States of America. 105: 512-7. PMID 18178619 DOI: 10.1073/Pnas.0710869105  1
2007 Fraser CS, Doudna JA. Quantitative studies of ribosome conformational dynamics. Quarterly Reviews of Biophysics. 40: 163-89. PMID 18072984 DOI: 10.1017/S0033583507004647  1
2007 MacRae IJ, Zhou K, Doudna JA. Structural determinants of RNA recognition and cleavage by Dicer. Nature Structural & Molecular Biology. 14: 934-40. PMID 17873886 DOI: 10.1038/Nsmb1293  1
2007 Gilbert WV, Zhou K, Butler TK, Doudna JA. Cap-independent translation is required for starvation-induced differentiation in yeast. Science (New York, N.Y.). 317: 1224-7. PMID 17761883 DOI: 10.1126/Science.1144467  1
2007 MacRae IJ, Doudna JA. An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer. Acta Crystallographica. Section D, Biological Crystallography. 63: 993-9. PMID 17704568 DOI: 10.1107/S0907444907036128  1
2007 Fraser CS, Berry KE, Hershey JW, Doudna JA. eIF3j is located in the decoding center of the human 40S ribosomal subunit. Molecular Cell. 26: 811-9. PMID 17588516 DOI: 10.1016/J.Molcel.2007.05.019  1
2007 Kiessling LL, Doudna JA, Johnsson K, Mapp AK, Marletta MA, Seeberger PH, Williamson JR, Wedde SG. A higher degree of difficulty. Acs Chemical Biology. 2: 197-9. PMID 17455890 DOI: 10.1021/Cb7000846  0.28
2007 Ke A, Ding F, Batchelor JD, Doudna JA. Structural roles of monovalent cations in the HDV ribozyme. Structure (London, England : 1993). 15: 281-7. PMID 17355864 DOI: 10.1016/J.Str.2007.01.017  1
2007 Damoc E, Fraser CS, Zhou M, Videler H, Mayeur GL, Hershey JW, Doudna JA, Robinson CV, Leary JA. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Molecular & Cellular Proteomics : McP. 6: 1135-46. PMID 17322308 DOI: 10.1074/Mcp.M600399-Mcp200  1
2007 MacRae IJ, Doudna JA. Ribonuclease revisited: structural insights into ribonuclease III family enzymes. Current Opinion in Structural Biology. 17: 138-45. PMID 17194582 DOI: 10.1016/J.Sbi.2006.12.002  1
2007 Siu FY, Spanggord RJ, Doudna JA. SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting. Rna (New York, N.Y.). 13: 240-50. PMID 17164479 DOI: 10.1261/Rna.135407  1
2007 Fraser CS, Doudna JA. Structural and mechanistic insights into hepatitis C viral translation initiation. Nature Reviews. Microbiology. 5: 29-38. PMID 17128284 DOI: 10.1038/Nrmicro1558  1
2007 Wu S, Ke A, Doudna JA. A fast and efficient procedure to produce scFvs specific for large macromolecular complexes. Journal of Immunological Methods. 318: 95-101. PMID 17126854 DOI: 10.1016/J.Jim.2006.10.005  1
2007 Doudna JA. The right chemistry: An updated nucleic acids textbook Acs Chemical Biology. 2: 211-212. DOI: 10.1021/Cb700048G  1
2006 Macrae IJ, Li F, Zhou K, Cande WZ, Doudna JA. Structure of Dicer and mechanistic implications for RNAi. Cold Spring Harbor Symposia On Quantitative Biology. 71: 73-80. PMID 17381283 DOI: 10.1101/Sqb.2006.71.042  1
2006 Green R, Doudna JA. RNAs regulate biology. Acs Chemical Biology. 1: 335-8. PMID 17163766 DOI: 10.1021/Cb600277M  1
2006 Chmiel NH, Rio DC, Doudna JA. Distinct contributions of KH domains to substrate binding affinity of Drosophila P-element somatic inhibitor protein. Rna (New York, N.Y.). 12: 283-91. PMID 16428607 DOI: 10.1261/Rna.2175706  1
2006 Macrae IJ, Zhou K, Li F, Repic A, Brooks AN, Cande WZ, Adams PD, Doudna JA. Structural basis for double-stranded RNA processing by Dicer. Science (New York, N.Y.). 311: 195-8. PMID 16410517 DOI: 10.1126/Science.1121638  1
2006 Karbstein K, Doudna JA. GTP-dependent formation of a ribonucleoprotein subcomplex required for ribosome biogenesis. Journal of Molecular Biology. 356: 432-43. PMID 16376378 DOI: 10.1016/J.Jmb.2005.11.052  1
2005 Doudna JA. Chemical biology at the crossroads of molecular structure and mechanism. Nature Chemical Biology. 1: 300-3. PMID 16408062 DOI: 10.1038/Nchembio1105-300  0.01
2005 Siridechadilok B, Fraser CS, Hall RJ, Doudna JA, Nogales E. Structural roles for human translation factor eIF3 in initiation of protein synthesis. Science (New York, N.Y.). 310: 1513-5. PMID 16322461 DOI: 10.1126/Science.1118977  1
2005 Karbstein K, Jonas S, Doudna JA. An essential GTPase promotes assembly of preribosomal RNA processing complexes. Molecular Cell. 20: 633-43. PMID 16307926 DOI: 10.1016/J.Molcel.2005.09.017  1
2005 Spanggord RJ, Siu F, Ke A, Doudna JA. RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle. Nature Structural & Molecular Biology. 12: 1116-22. PMID 16299512 DOI: 10.1038/Nsmb1025  1
2005 Chen L, Lullo DJ, Ma E, Celniker SE, Rio DC, Doudna JA. Identification and analysis of U5 snRNA variants in Drosophila. Rna (New York, N.Y.). 11: 1473-7. PMID 16199758 DOI: 10.1261/Rna.2141505  1
2005 Macrae IJ, Doudna JA. Ro's role in RNA reconnaissance. Cell. 121: 495-6. PMID 15907458 DOI: 10.1016/J.Cell.2005.05.004  1
2005 Yu Y, Ji H, Doudna JA, Leary JA. Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes. Protein Science : a Publication of the Protein Society. 14: 1438-46. PMID 15883184 DOI: 10.1110/Ps.041293005  1
2005 Doudna JA, Lorsch JR. Ribozyme catalysis: not different, just worse. Nature Structural & Molecular Biology. 12: 395-402. PMID 15870731 DOI: 10.1038/Nsmb932  1
2005 Aggarwal AK, Doudna JA. Protein-nucleic acid interactions: Unlocking mysteries old and new Current Opinion in Structural Biology. 15: 65-67. DOI: 10.1016/J.Sbi.2005.01.017  1
2004 Ji H, Fraser CS, Yu Y, Leary J, Doudna JA. Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA. Proceedings of the National Academy of Sciences of the United States of America. 101: 16990-5. PMID 15563596 DOI: 10.1073/Pnas.0407402101  1
2004 Ke A, Doudna JA. Crystallization of RNA and RNA-protein complexes. Methods (San Diego, Calif.). 34: 408-14. PMID 15325657 DOI: 10.1016/J.Ymeth.2004.03.027  1
2004 Doudna JA, Batey RT. Structural insights into the signal recognition particle. Annual Review of Biochemistry. 73: 539-57. PMID 15189152 DOI: 10.1146/Annurev.Biochem.73.011303.074048  1
2004 Rambo RP, Doudna JA. Assembly of an active group II intron-maturase complex by protein dimerization. Biochemistry. 43: 6486-97. PMID 15157082 DOI: 10.1021/Bi049912U  1
2004 Ke A, Zhou K, Ding F, Cate JH, Doudna JA. A conformational switch controls hepatitis delta virus ribozyme catalysis. Nature. 429: 201-5. PMID 15141216 DOI: 10.1038/Nature02522  1
2004 Karbstein K, Doudna JA. RNA: primed for packing? Chemistry & Biology. 11: 149-51. PMID 15123272 DOI: 10.1016/J.Chembiol.2004.02.007  1
2004 Lupták A, Doudna JA. Distinct sites of phosphorothioate substitution interfere with folding and splicing of the Anabaena group I intron. Nucleic Acids Research. 32: 2272-80. PMID 15107495 DOI: 10.1093/Nar/Gkh548  1
2004 Sagar MB, Lucast L, Doudna JA. Conserved but nonessential interaction of SRP RNA with translation factor EF-G. Rna (New York, N.Y.). 10: 772-8. PMID 15100432 DOI: 10.1261/Rna.5266504  1
2004 Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. The Journal of Biological Chemistry. 279: 8946-56. PMID 14688252 DOI: 10.1074/Jbc.M312745200  1
2002 Batey RT, Doudna JA. Structural and energetic analysis of metal ions essential to SRP signal recognition domain assembly. Biochemistry. 41: 11703-10. PMID 12269812 DOI: 10.1021/Bi026163C  1
2002 Battle DJ, Doudna JA. Specificity of RNA-RNA helix recognition. Proceedings of the National Academy of Sciences of the United States of America. 99: 11676-81. PMID 12189204 DOI: 10.1073/Pnas.182221799  0.92
2002 Doudna JA, Cech TR. The chemical repertoire of natural ribozymes. Nature. 418: 222-8. PMID 12110898 DOI: 10.1038/418222A  1
2002 Doudna JA, Rath VL. Structure and function of the eukaryotic ribosome: the next frontier. Cell. 109: 153-6. PMID 12007402 DOI: 10.1016/S0092-8674(02)00725-0  1
2002 Kieft JS, Zhou K, Grech A, Jubin R, Doudna JA. Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation. Nature Structural Biology. 9: 370-4. PMID 11927953 DOI: 10.1038/Nsb781  1
2002 Zhang L, Doudna JA. Structural insights into group II intron catalysis and branch-site selection. Science (New York, N.Y.). 295: 2084-8. PMID 11859154 DOI: 10.1126/Science.1069268  0.96
2001 Ferré-D'Amaré AR, Doudna JA. Methods to crystallize RNA. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 7.6. PMID 18428874 DOI: 10.1002/0471142700.Nc0706S00  1
2001 Kieft JS, Grech A, Adams P, Doudna JA. Mechanisms of internal ribosome entry in translation initiation Cold Spring Harbor Symposia On Quantitative Biology. 66: 277-283. PMID 12762029 DOI: 10.1101/Sqb.2001.66.277  1
2001 Murray JM, Doudna JA. Creative catalysis: Pieces of the RNA world jigsaw Trends in Biochemical Sciences. 26: 699-701. PMID 11738588 DOI: 10.1016/S0968-0004(01)02019-9  1
2001 Lupták A, Ferré-D'Amaré AR, Zhou K, Zilm KW, Doudna JA. Direct pK(a) measurement of the active-site cytosine in a genomic hepatitis delta virus ribozyme. Journal of the American Chemical Society. 123: 8447-52. PMID 11525650 DOI: 10.1021/Ja016091X  1
2001 Doherty EA, Doudna JA. Ribozyme structures and mechanisms. Annual Review of Biophysics and Biomolecular Structure. 30: 457-75. PMID 11441810 DOI: 10.1146/Annurev.Biophys.30.1.457  1
2001 Doherty EA, Batey RT, Masquida B, Doudna JA. A universal mode of helix packing in RNA. Nature Structural Biology. 8: 339-43. PMID 11276255 DOI: 10.1038/86221  1
2001 Lucast LJ, Batey RT, Doudna JA. Large-scale purification of a stable form of recombinant tobacco etch virus protease. Biotechniques. 30: 544-6, 548, 550 pass. PMID 11252791 DOI: 10.2144/01303St06  1
2001 Batey RT, Sagar MB, Doudna JA. Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle. Journal of Molecular Biology. 307: 229-46. PMID 11243816 DOI: 10.1006/Jmbi.2000.4454  1
2001 Spahn CM, Kieft JS, Grassucci RA, Penczek PA, Zhou K, Doudna JA, Frank J. Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit. Science (New York, N.Y.). 291: 1959-62. PMID 11239155 DOI: 10.1126/Science.1058409  1
2001 Kieft JS, Zhou K, Jubin R, Doudna JA. Mechanism of ribosome recruitment by hepatitis C IRES RNA. Rna (New York, N.Y.). 7: 194-206. PMID 11233977 DOI: 10.1017/S1355838201001790  1
2001 Battle DJ, Doudna JA. The stem-loop binding protein forms a highly stable and specific complex with the 3' stem-loop of histone mRNAs. Rna (New York, N.Y.). 7: 123-32. PMID 11214174 DOI: 10.1017/S1355838201001820  0.92
2000 Doudna JA. Structural genomics of RNA. Nature Structural Biology. 7: 954-6. PMID 11103998 DOI: 10.1038/80729  1
2000 Hanna RL, Gryaznov SM, Doudna JA. A phosphoramidate substrate analog is a competitive inhibitor of the Tetrahymena group I ribozyme. Chemistry & Biology. 7: 845-54. PMID 11094338 DOI: 10.1016/S1074-5521(00)00033-8  1
2000 Jubin R, Vantuno NE, Kieft JS, Murray MG, Doudna JA, Lau JY, Baroudy BM. Hepatitis C virus internal ribosome entry site (IRES) stem loop IIId contains a phylogenetically conserved GGG triplet essential for translation and IRES folding. Journal of Virology. 74: 10430-7. PMID 11044087 DOI: 10.1128/Jvi.74.22.10430-10437.2000  1
2000 Doherty EA, Doudna JA. Ribozyme structures and mechanisms. Annual Review of Biochemistry. 69: 597-615. PMID 10966470 DOI: 10.1146/Annurev.Biochem.69.1.597  1
2000 Cate JH, Doudna JA. Solving large RNA structures by X-ray crystallography Methods in Enzymology. 317: 169-180. PMID 10829280 DOI: 10.1016/S0076-6879(00)17014-4  1
2000 Jeruzalmi D, Kuriyan J, Doudna J. Paul Sigler (1934-2000). Trends in Biochemical Sciences. 25: 221-2. PMID 10782089 DOI: 10.1016/S0968-0004(00)01587-5  1
2000 Hanna R, Doudna JA. Metal ions in ribozyme folding and catalysis Current Opinion in Chemical Biology. 4: 166-170. PMID 10742186 DOI: 10.1016/S1367-5931(99)00071-X  1
2000 Engelhardt MA, Doherty EA, Knitt DS, Doudna JA, Herschlag D. The P5abc peripheral element facilitates preorganization of the tetrahymena group I ribozyme for catalysis. Biochemistry. 39: 2639-51. PMID 10704214 DOI: 10.1021/Bi992313G  1
2000 Batey RT, Rambo RP, Lucast L, Rha B, Doudna JA. Crystal structure of the ribonucleoprotein core of the signal recognition particle. Science (New York, N.Y.). 287: 1232-9. PMID 10678824 DOI: 10.1126/Science.287.5456.1232  1
2000 Ferré-D'Amaré AR, Doudna JA. Crystallization and structure determination of a hepatitis delta virus ribozyme: use of the RNA-binding protein U1A as a crystallization module. Journal of Molecular Biology. 295: 541-56. PMID 10623545 DOI: 10.1006/Jmbi.1999.3398  1
1999 Doudna JA. Ribosomes: Cashing in on crystals Current Biology. 9: R731-R734. PMID 10530999 DOI: 10.1016/S0960-9822(99)80470-9  1
1999 Kieft JS, Zhou K, Jubin R, Murray MG, Lau JY, Doudna JA. The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold. Journal of Molecular Biology. 292: 513-29. PMID 10497018 DOI: 10.1006/Jmbi.1999.3095  1
1999 Batey RT, Rambo RP, Doudna JA. Tertiary Motifs in RNA Structure and Folding. Angewandte Chemie (International Ed. in English). 38: 2326-2343. PMID 10458781 DOI: 10.1002/(Sici)1521-3773(19990816)38:16<2326::Aid-Anie2326>3.0.Co;2-3  1
1999 Ferré-D'Amaré AR, Doudna JA. RNA folds: insights from recent crystal structures. Annual Review of Biophysics and Biomolecular Structure. 28: 57-73. PMID 10410795 DOI: 10.1146/Annurev.Biophys.28.1.57  1
1999 Wadkins TS, Perrotta AT, Ferré-D'Amaré AR, Doudna JA, Been MD. A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes. Rna (New York, N.Y.). 5: 720-7. PMID 10376872 DOI: 10.1017/S1355838299990209  1
1999 Doherty EA, Herschlag D, Doudna JA. Assembly of an exceptionally stable RNA tertiary interface in a group I ribozyme. Biochemistry. 38: 2982-90. PMID 10074350 DOI: 10.1021/Bi982113P  1
1998 Basu S, Rambo RP, Strauss-Soukup J, Cate JH, Ferré-D'Amaré AR, Strobel SA, Doudna JA. A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor. Nature Structural Biology. 5: 986-92. PMID 9808044 DOI: 10.1038/2960  1
1998 Ferré-D'Amaré AR, Zhou K, Doudna JA. Crystal structure of a hepatitis delta virus ribozyme. Nature. 395: 567-74. PMID 9783582 DOI: 10.1038/26912  1
1998 Doudna JA. Ribozymes: The hammerhead swings into action Current Biology. 8: R495-R497. PMID 9663384 DOI: 10.1016/S0960-9822(98)70316-1  1
1998 Ferré-D'Amaré AR, Zhou K, Doudna JA. A general module for RNA crystallization. Journal of Molecular Biology. 279: 621-31. PMID 9641982 DOI: 10.1006/Jmbi.1998.1789  1
1998 Batey RT, Doudna JA. The parallel universe of RNA folding. Nature Structural Biology. 5: 337-40. PMID 9586989 DOI: 10.1038/Nsb0598-337  1
1998 Richmond TJ, Steitz TA. Protein-nucleic acid interactions. Current Opinion in Structural Biology. 8: 11-3. PMID 9519290 DOI: 10.1016/S0959-440X(98)80003-1  1
1998 Doherty EA, Rambo R, Doudna JA. Assembly of a ribozyme active site Faseb Journal. 12: A1315.  1
1997 Doudna JA, Doherty EA. Emerging themes in RNA folding. Folding & Design. 2: R65-70. PMID 9377708 DOI: 10.1016/S1359-0278(97)00035-7  1
1997 Doudna JA. A molecular contortionist Nature. 388: 830-831. PMID 9278040 DOI: 10.1038/42139  1
1997 Strobel SA, Doudna JA. RNA seeing double: close-packing of helices in RNA tertiary structure. Trends in Biochemical Sciences. 22: 262-6. PMID 9255068 DOI: 10.1016/S0968-0004(97)01056-6  1
1997 Cate JH, Hanna RL, Doudna JA. A magnesium ion core at the heart of a ribozyme domain. Nature Structural Biology. 4: 553-8. PMID 9228948 DOI: 10.1038/Nsb0797-553  1
1997 Cate JH, Doudna JA. A sparse matrix approach to crystallizing ribozymes and RNA motifs Methods in Molecular Biology (Clifton, N.J.). 74: 379-386. PMID 9204453 DOI: 10.1385/0-89603-389-9:379  1
1997 Ferré-d'Amaré AR, Doudna JA. Establishing suitability of RNA preparations for crystallization. Determination of polydispersity Methods in Molecular Biology (Clifton, N.J.). 74: 371-377. PMID 9204452 DOI: 10.1385/0-89603-389-9:371  1
1997 Doudna JA. Preparation of homogeneous ribozyme RNA for crystallization Methods in Molecular Biology (Clifton, N.J.). 74: 365-370. PMID 9204451 DOI: 10.1385/0-89603-389-9:365  1
1997 Doudna JA, Cate JH. RNA structure: Crystal clear? Current Opinion in Structural Biology. 7: 310-316. PMID 9204271 DOI: 10.1016/S0959-440X(97)80045-0  1
1997 Doherty EA, Doudna JA. The P4-P6 domain directs higher order folding of the Tetrahymena ribozyme core. Biochemistry. 36: 3159-69. PMID 9115992 DOI: 10.1021/Bi962428+  1
1997 Gate JH, Hanna RL, Doudna JA. A metal ion core at the heart of a l. argk ribozyme domain Faseb Journal. 11: A1445.  1
1997 Cate JH, Doherty EA, Doudna JA. Crystal structure of A group I ribozyme domain reveals principles of higher order RNA folding Protein Engineering. 10: 41.  1
1996 Cate JH, Doudna JA. Metal-binding sites in the major groove of a large ribozyme domain Structure. 4: 1221-1229. PMID 8939748 DOI: 10.1016/S0969-2126(96)00129-3  1
1996 Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Szewczak AA, Kundrot CE, Cech TR, Doudna JA. RNA tertiary structure mediation by adenosine platforms. Science (New York, N.Y.). 273: 1696-9. PMID 8781229 DOI: 10.1126/Science.273.5282.1696  1
1996 Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA. Crystal structure of a group I ribozyme domain: principles of RNA packing. Science (New York, N.Y.). 273: 1678-85. PMID 8781224 DOI: 10.1126/Science.273.5282.1678  1
1996 Ferré-D'Amaré AR, Doudna JA. Use of cis- and trans-ribozymes to remove 5′ and 3′ heterogeneities from milligrams of in vitro transcribed RNA Nucleic Acids Research. 24: 977-978. PMID 8600468 DOI: 10.1093/Nar/24.5.977  1
1996 Jones JT, Barnes CL, Lietzke SE, Weichenrieder O, Doudna JA, Kundrot CE. Preliminary X-ray diffraction studies of an RNA pseudoknot that inhibits HIV-1 reverse transcriptase Acta Crystallographica Section D: Biological Crystallography. 52: 1018-1020. DOI: 10.1107/S0907444996004234  1
1995 Doudna JA. Hammerhead ribozyme structure: U-turn for RNA structural biology Structure. 3: 747-750. PMID 7582890 DOI: 10.1016/S0969-2126(01)00208-8  1
1995 Doudna JA, Cech TR, Sullenger BA. Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 92: 2355-9. PMID 7534420 DOI: 10.1073/Pnas.92.6.2355  1
1995 Doudna JA, Cech TR. Self-assembly of a group I intron active site from its component tertiary structural domains. Rna (New York, N.Y.). 1: 36-45. PMID 7489486  1
1994 Doudna JA. Hammering out the shape of a ribozyme Structure. 2: 1271-1272. PMID 7704535 DOI: 10.1016/S0969-2126(94)00127-8  1
1993 Doudna JA, Grosshans C, Gooding A, Kundrot CE. Crystallization of ribozymes and small RNA motifs by a sparse matrix approach. Proceedings of the National Academy of Sciences of the United States of America. 90: 7829-33. PMID 8356090  1
1993 Doudna JA, Usman N, Szostak JW. Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA. Biochemistry. 32: 2111-5. PMID 7680575 DOI: 10.1021/Bi00059A032  1
1991 Bartel DP, Doudna JA, Usman N, Szostak JW. Template-directed primer extension catalyzed by the Tetrahymena ribozyme. Molecular and Cellular Biology. 11: 3390-4. PMID 2038341 DOI: 10.1128/Mcb.11.6.3390  1
1991 Doudna JA, Couture S, Szostak JW. A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis. Science (New York, N.Y.). 251: 1605-8. PMID 1707185 DOI: 10.1126/Science.1707185  1
1990 Doudna JA, Szostak JW, Rich A, Usman N. Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function. The Journal of Organic Chemistry. 55: 5547-9. PMID 11540922 DOI: 10.1021/Jo00308A003  1
1990 Couture S, Ellington AD, Gerber AS, Cherry JM, Doudna JA, Green R, Hanna M, Pace U, Rajagopal J, Szostak JW. Mutational analysis of conserved nucleotides in a self-splicing group I intron. Journal of Molecular Biology. 215: 345-58. PMID 1700131 DOI: 10.1016/S0022-2836(05)80356-0  1
1989 Doudna JA, Szostak JW. Miniribozymes, small derivatives of the sunY intron, are catalytically active. Molecular and Cellular Biology. 9: 5480-3. PMID 2685567 DOI: 10.1128/Mcb.9.12.5480  1
1989 Doudna JA, Cormack BP, Szostak JW. RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. Proceedings of the National Academy of Sciences of the United States of America. 86: 7402-6. PMID 2678103 DOI: 10.1073/Pnas.86.19.7402  1
1989 Doudna JA, Szostak JW. RNA-catalysed synthesis of complementary-strand RNA. Nature. 339: 519-22. PMID 2660003 DOI: 10.1038/339519A0  1
1989 Rajagopal J, Doudna JA, Szostak JW. Stereochemical course of catalysis by the Tetrahymena ribozyme. Science (New York, N.Y.). 244: 692-4. PMID 2470151 DOI: 10.1126/Science.2470151  1
1989 Doudna JA, Szostak JW. RNA-catalysed synthesis of complementary strand RNA Trends in Genetics. 5: 323. DOI: 10.1016/0168-9525(89)90125-X  1
1987 Doudna JA, Gerber AS, Cherry JM, Szostak JW. Genetic dissection of an RNA enzyme. Cold Spring Harbor Symposia On Quantitative Biology. 52: 173-80. PMID 2456876 DOI: 10.1101/Sqb.1987.052.01.022  1
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