Gerald F. Joyce - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Directed Evolution of RNA and DNA Enzymes
Website:
http://www.scripps.edu/mb/joyce/joyce.html

207 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Portillo X, Huang YT, Breaker RR, Horning DP, Joyce GF. Witnessing the structural evolution of an RNA enzyme. Elife. 10. PMID 34498588 DOI: 10.7554/eLife.71557  1
2020 Setterholm NA, Haratipour P, Kashemirov BA, McKenna CE, Joyce GF. Kinetic Effects of β,γ-Modified Deoxynucleoside 5'-Triphosphate Analogues on RNA-Catalyzed Polymerization of DNA. Biochemistry. PMID 33356161 DOI: 10.1021/acs.biochem.0c00779  0.01
2020 Tjhung KF, Sczepanski JT, Murtfeldt ER, Joyce GF. RNA-Catalyzed Cross-Chiral Polymerization of RNA. Journal of the American Chemical Society. 142: 15331-15339. PMID 32805113 DOI: 10.1021/Jacs.0C05635  1
2020 Salditt A, Keil LMR, Horning DP, Mast CB, Joyce GF, Braun D. Thermal Habitat for RNA Amplification and Accumulation. Physical Review Letters. 125: 048104. PMID 32794805 DOI: 10.1103/Physrevlett.125.048104  1
2020 Tjhung KF, Shokhirev MN, Horning DP, Joyce GF. An RNA polymerase ribozyme that synthesizes its own ancestor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31988127 DOI: 10.1073/Pnas.1914282117  1
2019 Horning DP, Bala S, Chaput JC, Joyce GF. RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids. Acs Synthetic Biology. PMID 31042360 DOI: 10.1021/Acssynbio.9B00044  1
2019 Pressman AD, Liu Z, Janzen E, Blanco C, Müller UF, Joyce GF, Pascal R, Chen IA. Mapping a systematic ribozyme fitness landscape reveals a frustrated evolutionary network for self-aminoacylating RNA. Journal of the American Chemical Society. PMID 30912655 DOI: 10.1021/Jacs.8B13298  0.01
2018 Joyce GF, Szostak JW. Protocells and RNA Self-Replication. Cold Spring Harbor Perspectives in Biology. 10. PMID 30181195 DOI: 10.1101/Cshperspect.A034801  1
2018 Samanta B, Horning DP, Joyce GF. 3'-End labeling of nucleic acids by a polymerase ribozyme. Nucleic Acids Research. PMID 29901762 DOI: 10.1093/Nar/Gky513  1
2017 Joyce GF, Samanta B. A reverse transcriptase ribozyme. Elife. 6. PMID 28949294 DOI: 10.7554/Elife.31153  1
2017 Samanta B, Joyce GF. Author response: A reverse transcriptase ribozyme Elife. DOI: 10.7554/Elife.31153.016  1
2016 Olea C, Joyce GF. Real-Time Detection of a Self-Replicating RNA Enzyme. Molecules (Basel, Switzerland). 21. PMID 27706059 DOI: 10.3390/Molecules21101310  1
2016 Horning DP, Joyce GF. Amplification of RNA by an RNA polymerase ribozyme. Proceedings of the National Academy of Sciences of the United States of America. PMID 27528667 DOI: 10.1073/Pnas.1610103113  1
2015 Sczepanski JT, Joyce GF. Specific Inhibition of MicroRNA Processing Using L-RNA Aptamers. Journal of the American Chemical Society. PMID 26652064 DOI: 10.1021/Jacs.5B06696  1
2015 Joyce GF. Reflections of a Darwinian Engineer. Journal of Molecular Evolution. 81: 146-9. PMID 26597943 DOI: 10.1007/S00239-015-9724-6  1
2015 Olea C, Weidmann J, Dawson PE, Joyce GF. An L-RNA Aptamer that Binds and Inhibits RNase. Chemistry & Biology. 22: 1437-41. PMID 26590636 DOI: 10.1016/J.Chembiol.2015.09.017  1
2015 Zissimopoulos J, Joyce GF, Scarpati LM, Goldman DP. Did Medicare Part D reduce disparities? The American Journal of Managed Care. 21: 119-28. PMID 25880361  1
2015 Olea C, Joyce GF. Ligand-dependent exponential amplification of self-replicating RNA enzymes. Methods in Enzymology. 550: 23-39. PMID 25605379 DOI: 10.1016/Bs.Mie.2014.10.030  1
2014 Sczepanski JT, Joyce GF. A cross-chiral RNA polymerase ribozyme. Nature. 515: 440-2. PMID 25363769 DOI: 10.1038/Nature13900  1
2014 Breaker RR, Joyce GF. The expanding view of RNA and DNA function. Chemistry & Biology. 21: 1059-65. PMID 25237854 DOI: 10.1016/J.Chembiol.2014.07.008  1
2014 Petrie KL, Joyce GF. Limits of neutral drift: lessons from the in vitro evolution of two ribozymes. Journal of Molecular Evolution. 79: 75-90. PMID 25155818 DOI: 10.1007/S00239-014-9642-Z  1
2014 Robertson MP, Joyce GF. Highly efficient self-replicating RNA enzymes. Chemistry & Biology. 21: 238-45. PMID 24388759 DOI: 10.1016/J.Chembiol.2013.12.004  1
2013 Joyce GF, Zissimopoulos J, Goldman DP. Digesting the doughnut hole. Journal of Health Economics. 32: 1345-55. PMID 24308883 DOI: 10.1016/j.jhealeco.2013.04.007  1
2013 Sczepanski JT, Joyce GF. Binding of a structured D-RNA molecule by an L-RNA aptamer. Journal of the American Chemical Society. 135: 13290-3. PMID 23977945 DOI: 10.1021/Ja406634G  1
2013 Ferretti AC, Joyce GF. Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification. Biochemistry. 52: 1227-35. PMID 23384307 DOI: 10.1021/Bi301646N  1
2013 Dunitz JD, Joyce GF. Leslie Eleazer Orgel. 12 January 1927 — 27 October 2007 Biographical Memoirs of Fellows of the Royal Society. 59: 277-289. DOI: 10.1098/Rsbm.2013.0002  0.01
2012 Darkow T, Maclean R, Joyce GF, Goldman D, Lakdawalla DN. Coverage and use of cancer therapies in the treatment of chronic myeloid leukemia. The American Journal of Managed Care. 18: S272-8. PMID 23327459  1
2012 Sczepanski JT, Joyce GF. Synthetic evolving systems that implement a user-specified genetic code of arbitrary design. Chemistry & Biology. 19: 1324-32. PMID 23102225 DOI: 10.1016/J.Chembiol.2012.08.017  1
2012 Joyce GF. Bit by bit: the Darwinian basis of life. Plos Biology. 10: e1001323. PMID 22589698 DOI: 10.1371/Journal.Pbio.1001323  1
2012 Olea C, Horning DP, Joyce GF. Ligand-dependent exponential amplification of a self-replicating L-RNA enzyme. Journal of the American Chemical Society. 134: 8050-3. PMID 22551009 DOI: 10.1021/Ja302197X  1
2012 Joyce GF. Evolution. Toward an alternative biology. Science (New York, N.Y.). 336: 307-8. PMID 22517850 DOI: 10.1126/Science.1221724  1
2012 Karaca-Mandic P, Jena AB, Joyce GF, Goldman DP. Out-of-pocket medication costs and use of medications and health care services among children with asthma. Jama. 307: 1284-91. PMID 22453569 DOI: 10.1001/Jama.2012.340  1
2012 Robertson MP, Joyce GF. The origins of the RNA world. Cold Spring Harbor Perspectives in Biology. 4. PMID 20739415 DOI: 10.1101/Cshperspect.A003608  1
2012 Goldman DP, Joyce GF. Consumer Demand and Health Effects of Cost-Sharing The Oxford Handbook of the Economics of the Biopharmaceutical Industry. DOI: 10.1093/oxfordhb/9780199742998.013.0012  1
2011 Goldman DP, Joyce GF, Vogt WB. Part D Formulary and Benefit Design as a Risk-Steering Mechanism. The American Economic Review. 101: 382-386. PMID 25067840 DOI: 10.1257/aer.101.3.382  1
2011 Joyce GF, Carrera MP, Goldman DP, Sood N. Physician prescribing behavior and its impact on patient-level outcomes. The American Journal of Managed Care. 17: e462-71. PMID 22216870  1
2011 Lam BJ, Joyce GF. An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification. Journal of the American Chemical Society. 133: 3191-7. PMID 21322594 DOI: 10.1021/Ja111136D  1
2011 Meeker D, Joyce GF, Malkin J, Teutsch SM, Haddix AC, Goldman DP. Coverage and preventive screening. Health Services Research. 46: 173-84. PMID 21029084 DOI: 10.1111/j.1475-6773.2010.01188.x  1
2010 Joyce GF. Understanding Primary Nonadherence. The American Journal of Pharmacy Benefits. 2: 111-118. PMID 24466385  1
2010 Karaca-Mandic P, Joyce GF, Goldman DP, Laouri M. Cost sharing, family health care burden, and the use of specialty drugs for rheumatoid arthritis. Health Services Research. 45: 1227-50. PMID 20831715 DOI: 10.1111/j.1475-6773.2010.01117.x  1
2010 Petrie KL, Joyce GF. Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs. Nucleic Acids Research. 38: 8095-104. PMID 20693528 DOI: 10.1093/Nar/Gkq685  1
2010 Paegel BM, Joyce GF. Microfluidic compartmentalized directed evolution. Chemistry & Biology. 17: 717-24. PMID 20659684 DOI: 10.1016/J.Chembiol.2010.05.021  1
2010 Joyce GF, Dai X, De Mesmaeker A. Amide cleavage by a ribozyme: correction. Science (New York, N.Y.). 272: 18c-9c. PMID 17789965 DOI: 10.1126/Science.272.5258.18C  0.01
2009 Joyce GF, Goldman DP, Vogt WB, Sun E, Jena AB. Medicare part D after 2 years. The American Journal of Managed Care. 15: 536-44. PMID 19670957  1
2009 Joyce GF. Evolution in an RNA world. Cold Spring Harbor Symposia On Quantitative Biology. 74: 17-23. PMID 19667013 DOI: 10.1101/Sqb.2009.74.004  1
2009 Voytek SB, Joyce GF. Niche partitioning in the coevolution of 2 distinct RNA enzymes. Proceedings of the National Academy of Sciences of the United States of America. 106: 7780-5. PMID 19416904 DOI: 10.1073/Pnas.0903397106  1
2009 Solomon MD, Goldman DP, Joyce GF, Escarce JJ. Cost sharing and the initiation of drug therapy for the chronically ill. Archives of Internal Medicine. 169: 740-8; discussion 74. PMID 19398684 DOI: 10.1001/Archinternmed.2009.62  1
2009 Lam BJ, Joyce GF. Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA. Nature Biotechnology. 27: 288-92. PMID 19234448 DOI: 10.1038/Nbt.1528  1
2009 Lincoln TA, Joyce GF. Self-sustained replication of an RNA enzyme. Science (New York, N.Y.). 323: 1229-32. PMID 19131595 DOI: 10.1126/Science.1167856  1
2008 Joyce GF, Goldman DP, Karaca-Mandic P, Lawless GD. Impact of specialty drugs on the use of other medical services. The American Journal of Managed Care. 14: 821-8. PMID 19067499  1
2008 Joyce GF, Niaura R, Maglione M, Mongoven J, Larson-Rotter C, Coan J, Lapin P, Morton S. The effectiveness of covering smoking cessation services for medicare beneficiaries. Health Services Research. 43: 2106-23. PMID 18783459 DOI: 10.1111/j.1475-6773.2008.00891.x  1
2008 Goldman DP, Joyce GF. Medicare Part D: a successful start with room for improvement. Jama. 299: 1954-5. PMID 18430916 DOI: 10.1001/jama.299.16.1954  1
2008 Paegel BM, Joyce GF. Darwinian evolution on a chip. Plos Biology. 6: e85. PMID 18399721 DOI: 10.1371/Journal.Pbio.0060085  1
2008 Paegel BM, Joyce GF. Microfluidic darwinian evolution 12th International Conference On Miniaturized Systems For Chemistry and Life Sciences - the Proceedings of Microtas 2008 Conference. 637-639.  1
2007 Joyce GF. Obituary: Leslie Orgel (1927-2007). Nature. 450: 627. PMID 18046392 DOI: 10.1038/450627A  1
2007 Voytek SB, Joyce GF. Emergence of a fast-reacting ribozyme that is capable of undergoing continuous evolution. Proceedings of the National Academy of Sciences of the United States of America. 104: 15288-93. PMID 17878292 DOI: 10.1073/Pnas.0707490104  1
2007 Joyce GF, Goldman DP, Karaca-Mandic P, Zheng Y. Pharmacy benefit caps and the chronically ill. Health Affairs (Project Hope). 26: 1333-44. PMID 17848444 DOI: 10.1377/hlthaff.26.5.1333  1
2007 Joyce GF. Forty years of in vitro evolution. Angewandte Chemie (International Ed. in English). 46: 6420-36. PMID 17634987 DOI: 10.1002/Anie.200701369  1
2007 Goldman DP, Joyce GF, Zheng Y. Prescription drug cost sharing: associations with medication and medical utilization and spending and health. Jama. 298: 61-9. PMID 17609491 DOI: 10.1001/jama.298.1.61  1
2007 Meacham RB, Joyce GF, Wise M, Kparker A, Niederberger C. Male infertility. The Journal of Urology. 177: 2058-66. PMID 17509286 DOI: 10.1016/j.juro.2007.01.131  1
2007 Pontari MA, Joyce GF, Wise M, McNaughton-Collins M. Prostatitis. The Journal of Urology. 177: 2050-7. PMID 17509285 DOI: 10.1016/j.juro.2007.01.128  1
2007 Payne CK, Joyce GF, Wise M, Clemens JQ. Interstitial cystitis and painful bladder syndrome. The Journal of Urology. 177: 2042-9. PMID 17509284 DOI: 10.1016/J.Juro.2007.01.124  1
2007 Sokoloff MH, Joyce GF, Wise M. Testis cancer. The Journal of Urology. 177: 2030-41. PMID 17509283 DOI: 10.1016/j.juro.2007.01.127  1
2007 Wallen EM, Pruthi RS, Joyce GF, Wise M. Kidney cancer. The Journal of Urology. 177: 2006-18; discussion . PMID 17509280 DOI: 10.1016/j.juro.2007.01.126  1
2007 Wessells H, Joyce GF, Wise M, Wilt TJ. Erectile dysfunction. The Journal of Urology. 177: 1675-81. PMID 17437781 DOI: 10.1016/j.juro.2007.01.057  1
2007 Santucci RA, Joyce GF, Wise M. Male urethral stricture disease. The Journal of Urology. 177: 1667-74. PMID 17437780 DOI: 10.1016/J.Juro.2007.01.041  1
2007 Pohl HG, Joyce GF, Wise M, Cilento BG. Vesicoureteral reflux and ureteroceles. The Journal of Urology. 177: 1659-66. PMID 17437779 DOI: 10.1016/J.Juro.2007.01.059  1
2007 Pohl HG, Joyce GF, Wise M, Cilento BG. Cryptorchidism and hypospadias. The Journal of Urology. 177: 1646-51. PMID 17437777 DOI: 10.1016/J.Juro.2007.01.058  1
2007 Konety BR, Joyce GF, Wise M. Bladder and upper tract urothelial cancer. The Journal of Urology. 177: 1636-45. PMID 17437776 DOI: 10.1016/J.Juro.2007.01.055  1
2007 Joyce GF. Structural biology. A glimpse of biology's first enzyme. Science (New York, N.Y.). 315: 1507-8. PMID 17363651 DOI: 10.1126/Science.1140736  1
2007 Joyce G. Vierzig Jahre Evolution im Reagenzglas Angewandte Chemie. 119: 6540-6557. DOI: 10.1002/Ange.200701369  0.01
2006 Cadwell RC, Joyce GF. Mutagenic PCR. Csh Protocols. 2006. PMID 22485544 DOI: 10.1101/pdb.prot4143  1
2006 Paegel BM, Grover WH, Skelley AM, Mathies RA, Joyce GF. Microfluidic serial dilution circuit. Analytical Chemistry. 78: 7522-7. PMID 17073422 DOI: 10.1021/Ac0608265  1
2006 Goldman DP, Joyce GF, Lawless G, Crown WH, Willey V. Benefit design and specialty drug use. Health Affairs (Project Hope). 25: 1319-31. PMID 16966729 DOI: 10.1377/hlthaff.25.5.1319  1
2006 Paul N, Springsteen G, Joyce GF. Conversion of a ribozyme to a deoxyribozyme through in vitro evolution. Chemistry & Biology. 13: 329-38. PMID 16638538 DOI: 10.1016/J.Chembiol.2006.01.007  1
2006 Goldman DP, Joyce GF, Karaca-Mandic P. Varying pharmacy benefits with clinical status: the case of cholesterol-lowering therapy. The American Journal of Managed Care. 12: 21-8. PMID 16402885  1
2006 Joyce GF, Orgel LE. 2 Progress toward Understanding the Origin of the RNA World Cold Spring Harbor Monograph Archive. 43: 23-56. DOI: 10.1101/087969739.43.23  1
2006 Joyce GF. Foreword The Aptamer Handbook: Functional Oligonucleotides and Their Applications. xix-xxi. DOI: 10.1002/3527608192  1
2005 Oberhuber M, Joyce GF. A DNA-templated aldol reaction as a model for the formation of pentose sugars in the RNA world. Angewandte Chemie (International Ed. in English). 44: 7580-3. PMID 16240312 DOI: 10.1002/Anie.200503387  1
2005 Joyce GF, Keeler EB, Shang B, Goldman DP. The lifetime burden of chronic disease among the elderly. Health Affairs (Project Hope). 24: W5R18-29. PMID 16186148 DOI: 10.1377/hlthaff.w5.r18  1
2005 Goldman DP, Shang B, Bhattacharya J, Garber AM, Hurd M, Joyce GF, Lakdawalla DN, Panis C, Shekelle PG. Consequences of health trends and medical innovation for the future elderly. Health Affairs (Project Hope). 24: W5R5-17. PMID 16186147 DOI: 10.1377/Hlthaff.W5.R5  1
2005 Joyce GF, Chan KS, Orlando M, Burnam MA. Mental health status and use of general medical services for persons with human immunodeficiency virus. Medical Care. 43: 834-9. PMID 16034298 DOI: 10.1097/01.mlr.0000170423.61316.05  1
2005 Johns GC, Joyce GF. The promise and peril of continuous in vitro evolution. Journal of Molecular Evolution. 61: 253-63. PMID 15999246 DOI: 10.1007/S00239-004-0307-1  1
2005 Joyce GF, Goldman DP, Leibowitz AA, Alpert A, Bao Y. A socioeconomic profile of older adults with HIV. Journal of Health Care For the Poor and Underserved. 16: 19-28. PMID 15741706 DOI: 10.1353/Hpu.2005.0013  1
2005 Litwin MS, Saigal CS, Yano EM, Avila C, Geschwind SA, Hanley JM, Joyce GF, Madison R, Pace J, Polich SM, Wang M. Urologic diseases in America Project: analytical methods and principal findings. The Journal of Urology. 173: 933-7. PMID 15711342 DOI: 10.1097/01.ju.0000152365.43125.3b  1
2005 Goldman DP, Joyce GF. Moving towards better formulary management. The American Journal of Managed Care. 11: 13-4. PMID 15697095  1
2005 Paegel BM, Joyce GF. Microfluidic serial transfer circuit: Automated evolution of RNA catalysts Micro Total Analysis Systems - Proceedings of Microtas 2005 Conference: 9th International Conference On Miniaturized Systems For Chemistry and Life Sciences. 1: 28-30.  1
2004 Bhattacharya J, Cutler DM, Goldman DP, Hurd MD, Joyce GF, Lakdawalla DN, Panis CW, Shang B. Disability forecasts and future Medicare costs. Frontiers in Health Policy Research / National Bureau of Economic Research. 7: 75-94. PMID 15612336 DOI: 10.2202/1558-9544.1052  1
2004 Paul N, Joyce GF. Minimal self-replicating systems. Current Opinion in Chemical Biology. 8: 634-9. PMID 15556408 DOI: 10.1016/J.Cbpa.2004.09.005  1
2004 Kim DE, Joyce GF. Cross-catalytic replication of an RNA ligase ribozyme. Chemistry & Biology. 11: 1505-12. PMID 15556001 DOI: 10.1016/J.Chembiol.2004.08.021  1
2004 Springsteen G, Joyce GF. Selective derivatization and sequestration of ribose from a prebiotic mix. Journal of the American Chemical Society. 126: 9578-83. PMID 15291561 DOI: 10.1021/Ja0483692  1
2004 Joyce GF. Directed evolution of nucleic acid enzymes. Annual Review of Biochemistry. 73: 791-836. PMID 15189159 DOI: 10.1146/Annurev.Biochem.73.011303.073717  1
2004 Goldman DP, Joyce GF, Escarce JJ, Pace JE, Solomon MD, Laouri M, Landsman PB, Teutsch SM. Pharmacy benefits and the use of drugs by the chronically ill. Jama. 291: 2344-50. PMID 15150206 DOI: 10.1001/Jama.291.19.2344  1
2004 Malkin JD, Goldman DP, Joyce GF. The changing face of pharmacy benefit design. Health Affairs (Project Hope). 23: 194-9. PMID 15002642 DOI: 10.1377/hlthaff.23.1.194  1
2004 Shih WM, Quispe JD, Joyce GF. A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron. Nature. 427: 618-21. PMID 14961116 DOI: 10.1038/Nature02307  1
2003 Kühne H, Joyce GF. Continuous in vitro evolution of ribozymes that operate under conditions of extreme pH. Journal of Molecular Evolution. 57: 292-8. PMID 14629039 DOI: 10.1007/S00239-003-2480-Z  1
2003 Goldman DP, Leibowitz AA, Joyce GF, Fleishman JA, Bozzette SA, Duan N, Shapiro MF. Insurance status of HIV-infected adults in the post-HAART era: evidence from the United States. Applied Health Economics and Health Policy. 2: 85-90. PMID 14619279  1
2003 Kumar RM, Joyce GF. A modular, bifunctional RNA that integrates itself into a target RNA. Proceedings of the National Academy of Sciences of the United States of America. 100: 9738-43. PMID 12913125 DOI: 10.1073/Pnas.1334190100  1
2003 Kuhns ST, Joyce GF. Perfectly complementary nucleic acid enzymes. Journal of Molecular Evolution. 56: 711-7. PMID 12911034 DOI: 10.1007/S00239-002-2445-7  1
2003 McGinness KE, Joyce GF. In search of an RNA replicase ribozyme. Chemistry & Biology. 10: 5-14. PMID 12573693 DOI: 10.1016/S1074-5521(03)00003-6  1
2003 Paul N, Joyce GF. Self-replication. Current Biology : Cb. 13: R46. PMID 12546800  1
2003 Lakdawalla D, Goldman DP, Bhattacharya J, Hurd MD, Joyce GF, Panis CW. Forecasting the nursing home population. Medical Care. 41: 8-20. PMID 12544538 DOI: 10.1097/01.MLR.0000017785.38545.59  1
2003 Clark BE, Garis RI, Hsu J, Reed M, Motheral B, Sheth J, Joyce GF, Goldman DP. Financial consequences of drug benefit plans [3] (multiple letters) Journal of the American Medical Association. 289: 423-424. PMID 12533118 DOI: 10.1001/JAMA.289.4.423-B  1
2002 Reader JS, Joyce GF. A ribozyme composed of only two different nucleotides. Nature. 420: 841-4. PMID 12490955 DOI: 10.1038/Nature01185  1
2002 Joyce GF. Molecular evolution: booting up life. Nature. 420: 278-9. PMID 12447426 DOI: 10.1038/420278A  1
2002 Ordoukhanian P, Joyce GF. RNA-cleaving DNA enzymes with altered regio- or enantioselectivity. Journal of the American Chemical Society. 124: 12499-506. PMID 12381192 DOI: 10.1021/ja027467p  1
2002 Joyce GF, Escarce JJ, Solomon MD, Goldman DP. Employer drug benefit plans and spending on prescription drugs. Jama. 288: 1733-9. PMID 12365957 DOI: 10.1001/Jama.288.14.1733  1
2002 Paul N, Joyce GF. A self-replicating ligase ribozyme. Proceedings of the National Academy of Sciences of the United States of America. 99: 12733-40. PMID 12239349 DOI: 10.1073/Pnas.202471099  1
2002 Joyce GF. The antiquity of RNA-based evolution. Nature. 418: 214-21. PMID 12110897 DOI: 10.1038/418214A  1
2002 McGinness KE, Wright MC, Joyce GF. Continuous in vitro evolution of a ribozyme that catalyzes three successive nucleotidyl addition reactions. Chemistry & Biology. 9: 585-96. PMID 12031665 DOI: 10.1016/S1074-5521(02)00136-9  1
2002 McGinness KE, Joyce GF. RNA-catalyzed RNA ligation on an external RNA template. Chemistry & Biology. 9: 297-307. PMID 11927255 DOI: 10.1016/S1074-5521(02)00110-2  1
2002 McGinness KE, Joyce GF. Substitution of ribonucleotides in the T7 RNA polymerase promoter element. The Journal of Biological Chemistry. 277: 2987-91. PMID 11704669 DOI: 10.1074/Jbc.M108820200  1
2001 Escarce JJ, Kapur K, Joyce GF, Van Vorst KA. Medical care expenditures under gatekeeper and point-of-service arrangements. Health Services Research. 36: 1037-57. PMID 11775666  1
2001 Joyce GF. RNA cleavage by the 10-23 DNA enzyme. Methods in Enzymology. 341: 503-17. PMID 11582801 DOI: 10.1016/S0076-6879(01)41173-6  1
2001 Zingmond DS, Wenger NS, Crystal S, Joyce GF, Liu H, Sambamoorthi U, Lillard LA, Leibowitz AA, Shapiro MF, Bozzette SA. Circumstances at HIV diagnosis and progression of disease in older HIV-infected Americans. American Journal of Public Health. 91: 1117-20. PMID 11441741 DOI: 10.2105/Ajph.91.7.1117  1
2001 Rogers J, Joyce GF. The effect of cytidine on the structure and function of an RNA ligase ribozyme. Rna (New York, N.Y.). 7: 395-404. PMID 11333020 DOI: 10.1017/S135583820100228X  1
2001 Goldman DP, Bhattacharya J, Leibowitz AA, Joyce GF, Shapiro MF, Bozzette SA. The impact of state policy on the costs of HIV infection. Medical Care Research and Review : McRr. 58: 31-53; discussion 54. PMID 11236232 DOI: 10.1177/107755870105800102  1
2001 Goldman DP, Bhattacharya J, Mccaffrey DF, Duan N, Leibowitz AA, Joyce GF, Morton SC. Effect of Insurance on Mortality in an HIV-Positive Population in Care Journal of the American Statistical Association. 96: 883-894.  1
2000 Dai X, Joyce GF. In vitro evolution of a ribozyme that contains 5-bromouridine. Helvetica Chimica Acta. 83: 1701-10. PMID 11543569 DOI: 10.1002/1522-2675(20000809)83:8<1701::Aid-Hlca1701>3.0.Co;2-1  1
2000 Santoro SW, Joyce GF, Sakthivel K, Gramatikova S, Barbas CF 3rd. RNA cleavage by a DNA enzyme with extended chemical functionality. Journal of the American Chemical Society. 122: 2433-9. PMID 11543272 DOI: 10.1021/Ja993688S  1
2000 Joyce GF, Kapur K, Van Vorst KA, Escarce JJ. Visits to primary care physicians and to specialists under gatekeeper and point-of-service arrangements. The American Journal of Managed Care. 6: 1189-96. PMID 11185844  1
2000 Sheppard TL, Wong CH, Joyce GF. Nucleoglycoconjugates: design and synthesis of a new class of DNA-carbohydrate conjugates. Angewandte Chemie (International Ed. in English). 39: 3660-3. PMID 11091431 DOI: 10.1002/1521-3773(20001016)39:20<3660::Aid-Anie3660>3.0.Co;2-L  1
2000 Joyce GF. RNA structure. Ribozyme evolution at the crossroads. Science (New York, N.Y.). 289: 401-2. PMID 10939951 DOI: 10.1126/Science.289.5478.401  1
2000 Sheppard TL, Ordoukhanian P, Joyce GF. A DNA enzyme with N-glycosylase activity. Proceedings of the National Academy of Sciences of the United States of America. 97: 7802-7. PMID 10884411 DOI: 10.1073/Pnas.97.14.7802  1
2000 Kapur K, Joyce GF, Van Vorst KA, Escarce JJ. Expenditures for physician services under alternative models of managed care. Medical Care Research and Review : McRr. 57: 161-81. PMID 10868071 DOI: 10.1177/107755870005700202  1
2000 Nowakowski J, Shim PJ, Stout CD, Joyce GF. Alternative conformations of a nucleic acid four-way junction. Journal of Molecular Biology. 300: 93-102. PMID 10864501 DOI: 10.1006/Jmbi.2000.3826  1
1999 Ordoukhanian P, Joyce GF. A molecular description of the evolution of resistance. Chemistry & Biology. 6: 881-9. PMID 10631516 DOI: 10.1016/S1074-5521(00)80007-1  1
1999 Jaeger L, Wright MC, Joyce GF. A complex ligase ribozyme evolved in vitro from a group I ribozyme domain. Proceedings of the National Academy of Sciences of the United States of America. 96: 14712-7. PMID 10611278 DOI: 10.1073/Pnas.96.26.14712  1
1999 Rogers J, Joyce GF. A ribozyme that lacks cytidine. Nature. 402: 323-5. PMID 10580507 DOI: 10.1038/46335  1
1999 Nowakowski J, Shim PJ, Joyce GF, Stout CD. Crystallization of the 10-23 DNA enzyme using a combinatorial screen of paired oligonucleotides. Acta Crystallographica. Section D, Biological Crystallography. 55: 1885-92. PMID 10531487 DOI: 10.1107/S0907444999010550  1
1999 Joyce GF. The counterforce. Current Biology : Cb. 9: R500-1. PMID 10421584 DOI: 10.1016/S0960-9822(99)80318-2  1
1999 Bartlett PA, Joyce GF. Combinatorial chemistry: the search continues Current Opinion in Chemical Biology. 3: 253-5. PMID 10359722 DOI: 10.1016/S1367-5931(99)80039-8  1
1999 Joyce GF, Goldman DP, Leibowitz A, Carlisle D, Duan N, Shapiro MF, Bozzette SA. Variation in inpatient resource use in the treatment of HIV: do the privately insured receive more care? Medical Care. 37: 220-7. PMID 10098566 DOI: 10.1097/00005650-199903000-00002  1
1999 Arrhenius G, Bada JL, Joyce GF, Lazcano A, Miller S, Orgel LE. Origin and ancestor: separate environments. Science (New York, N.Y.). 283: 792. PMID 10049121 DOI: 10.1126/Science.283.5403.791C  1
1999 Nowakowski J, Shim PJ, Prasad GS, Stout CD, Joyce GF. Crystal structure of an 82-nucleotide RNA-DNA complex formed by the 10-23 DNA enzyme. Nature Structural Biology. 6: 151-6. PMID 10048927 DOI: 10.1038/5839  1
1999 Joyce GF. APPENDIX 3: Reactions Catalyzed by RNA and DNA Enzymes Cold Spring Harbor Monograph Archive. 37: 687-690. DOI: 10.1101/087969589.37.687  0.01
1999 Joyce GF, Orgel LE. 2 Prospects for Understanding the Origin of the RNA World Cold Spring Harbor Monograph Archive. 37: 49-77. DOI: 10.1101/087969589.37.49  1
1999 Bartlett PA, Joyce GF. Combinatorial chemistry: The search continues. Editorial overview Current Opinion in Chemical Biology. 3: 253-255. DOI: 10.1016/S1367-5931(99)80039-8  1
1999 Joyce GF. Onward and upward Chemistry and Biology. 6: R1-R2. DOI: 10.1016/S1074-5521(99)80012-X  1
1998 Joyce GF, Orgel LE. The origins of life--a status report. The American Biology Teacher. 60: 10-2. PMID 11541103 DOI: 10.2307/4450404  1
1998 Santoro SW, Joyce GF. Mechanism and utility of an RNA-cleaving DNA enzyme. Biochemistry. 37: 13330-42. PMID 9748341 DOI: 10.1021/Bi9812221  1
1998 Joyce GF. Nucleic acid enzymes: playing with a fuller deck. Proceedings of the National Academy of Sciences of the United States of America. 95: 5845-7. PMID 9600881 DOI: 10.1073/Pnas.95.11.5845  1
1997 Hendrix M, Priestley ES, Joyce GF, Wong CH. Direct observation of aminoglycoside - RNA interactions by surface plasmon resonance Journal of the American Chemical Society. 119: 3641-3648. PMID 11540136 DOI: 10.1021/ja964290o  1
1997 Joyce GF, Still WC, Chapman KT. Combinatorial chemistry searching for a winning combination Current Opinion in Chemical Biology. 1: 3-4. PMID 9667845 DOI: 10.1016/S1367-5931(97)80101-9  0.01
1997 Joyce GF. Evolutionary chemistry: getting there from here. Science (New York, N.Y.). 276: 1658-9. PMID 9206829 DOI: 10.1126/Science.276.5319.1658  1
1997 Santoro SW, Joyce GF. A general purpose RNA-cleaving DNA enzyme Proceedings of the National Academy of Sciences of the United States of America. 94: 4262-4266. PMID 9113977 DOI: 10.1073/Pnas.94.9.4262  1
1997 Wright MC, Joyce GF. Continuous in vitro evolution of catalytic function. Science (New York, N.Y.). 276: 614-7. PMID 9110984 DOI: 10.1126/Science.276.5312.614  1
1997 Bruick RK, Koppitz M, Joyce GF, Orgel LE. A simple procedure for constructing 5'-amino-terminated oligodeoxynucleotides in aqueous solution. Nucleic Acids Research. 25: 1309-10. PMID 9092646 DOI: 10.1093/Nar/25.6.1309  1
1997 Joyce GF, Santoro SW. A small but very efficient DNA enzyme Faseb Journal. 11: A851.  1
1996 Tsang J, Joyce GF. Specialization of the DNA-cleaving activity of a group I ribozyme through in vitro evolution Journal of Molecular Biology. 262: 31-42. PMID 8809177 DOI: 10.1006/Jmbi.1996.0496  1
1996 Bruick RK, Dawson PE, Kent SB, Usman N, Joyce GF. Template-directed ligation of peptides to oligonucleotides. Chemistry & Biology. 3: 49-56. PMID 8807828 DOI: 10.1016/S1074-5521(96)90084-8  1
1996 Joyce GF. Ribozymes: Building the RNA world Current Biology. 6: 965-967. PMID 8805318 DOI: 10.1016/S0960-9822(02)00640-1  1
1996 Raillard SA, Joyce GF. Targeting sites within HIV-1 cDNA with a DNA-cleaving ribozyme Biochemistry. 35: 11693-11701. PMID 8794750 DOI: 10.1021/Bi960845G  1
1996 Tsang J, Joyce GF. In vitro evolution of randomized ribozymes Methods in Enzymology. 267: 410-425. PMID 8743329 DOI: 10.1016/S0076-6879(96)67025-6  1
1996 Joyce GF, Dai X, De Mesmaeker A. Amide cleavage by a ribozyme: Correction [3] Science. 272: 18-19. PMID 8600526  1
1996 Joyce GF, Dai X, De Mesmaeker A. Amide Cleavage by a Ribozyme: Correction Science. 272: 15f-19. DOI: 10.1126/science.272.5258.15f  0.01
1996 Bada JL, Arrhenlus G, Miller SL, Orgel L, Joyce G. The NASA specialized center of research and training (NSCORT) in exobiology Origins of Life and Evolution of the Biosphere. 26: 318-319. DOI: 10.1007/Bf02459783  0.04
1996 Joyce GF. The role of catalytic RNA in the origin and early evolution of life on earth Origins of Life and Evolution of the Biosphere. 26: 233-234. DOI: 10.1007/Bf02459730  0.01
1995 Breaker RR, Joyce GF. A DNA enzyme with Mg(2+)-dependent RNA phosphoesterase activity. Chemistry & Biology. 2: 655-60. PMID 9383471 DOI: 10.1016/1074-5521(95)90028-4  1
1995 Dai X, De Mesmaeker A, Joyce GF. Cleavage of an amide bond by a ribozyme Science. 267: 237-240. PMID 7809628 DOI: 10.1126/Science.7809628  1
1995 Breaker RR, Joyce GF. Self-incorporation of coenzymes by ribozymes. Journal of Molecular Evolution. 40: 551-8. PMID 7643406 DOI: 10.1007/Bf00160500  1
1994 Joyce GF. In vitro evolution of nucleic acids Current Opinion in Structural Biology. 4: 331-336. PMID 11539574 DOI: 10.1016/S0959-440X(94)90100-7  1
1994 Breaker RR, Joyce GF. A DNA enzyme that cleaves RNA. Chemistry & Biology. 1: 223-9. PMID 9383394 DOI: 10.1016/1074-5521(94)90014-0  1
1994 Tsang J, Joyce GF. Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme. Biochemistry. 33: 5966-73. PMID 8180226 DOI: 10.1021/Bi00185A038  0.01
1994 Chakrabarti AC, Breaker RR, Joyce GF, Deamer DW. Production of RNA by a polymerase protein encapsulated within phospholipid vesicles. Journal of Molecular Evolution. 39: 555-9. PMID 7528810 DOI: 10.1007/Bf00160400  1
1994 Breaker RR, Banerji A, Joyce GF. Continuous in vitro evolution of bacteriophage RNA polymerase promoters. Biochemistry. 33: 11980-6. PMID 7522554 DOI: 10.1021/Bi00205A037  0.92
1994 Breaker RR, Joyce GF. Inventing and improving ribozyme function: rational design versus iterative selection methods. Trends in Biotechnology. 12: 268-75. PMID 7519862 DOI: 10.1016/0167-7799(94)90138-4  1
1994 Breaker RR, Joyce GF. Emergence of a replicating species from an in vitro RNA evolution reaction. Proceedings of the National Academy of Sciences of the United States of America. 91: 6093-7. PMID 7517040 DOI: 10.1073/Pnas.91.13.6093  1
1994 Li T, Zeng Z, Estevez VA, Baldenius KU, Nicolaou KC, Joyce GF. Carbohydrate-Minor Groove Interactions in the Binding of Calicheamicin .gamma.1I to Duplex DNA Journal of the American Chemical Society. 116: 3709-3715. DOI: 10.1021/Ja00088A006  1
1994 Li T, Zeng Z, Estevez VA, Baldenius KU, Nicolaou KC, Joyce GF. Carbohydrate-minor groove interactions in the binding of calicheamicin γ1I to duplex DNA Journal of the American Chemical Society. 116: 3709-3715.  1
1993 Lehman N, Joyce GF. Evolution in vitro: analysis of a lineage of ribozymes Current Biology. 3: 723-734. PMID 11539560 DOI: 10.1016/0960-9822(93)90019-K  1
1993 Joyce GF. Climbing Darwin's ladder Current Biology. 3: 703-704. PMID 11539460 DOI: 10.1016/0960-9822(93)90074-X  1
1993 Joyce GF. Evolution of catalytic function Pure and Applied Chemistry. 65: 1205-1212. PMID 11537489 DOI: 10.1351/Pac199365061205  1
1993 Lehman N, Joyce GF. Evolution in vitro of an RNA enzyme with altered metal dependence Nature. 361: 182-185. PMID 8421526 DOI: 10.1038/361182A0  1
1993 Joyce GF, Orgel LE. 1 Prospects for Understanding the Origin of the RNA World Cold Spring Harbor Monograph Archive. 24: 1-25. DOI: 10.1101/087969380.24.1  1
1992 Beaudry AA, Joyce GF. Directed evolution of an RNA enzyme Science. 257: 635-641. PMID 1496376 DOI: 10.1126/Science.1496376  1
1992 Joyce GF. Directed molecular evolution Scientific American. 267: 90+93-97+4. PMID 1279798 DOI: 10.1038/Scientificamerican1292-90  1
1992 Cadwell RC, Joyce GF. Randomization of genes by PCR mutagenesis Genome Research. 2: 28-33. DOI: 10.1101/Gr.2.1.28  1
1992 Nicolaou KC, Tsay SC, Suzuki T, Joyce GF. DNA-carbohydrate interactions. Specific binding of the calicheamicin .gamma.1I oligosaccharide with duplex DNA Journal of the American Chemical Society. 114: 7555-7557. DOI: 10.1021/Ja00045A033  1
1992 Nicolaou KC, Tsay SC, Suzuki T, Joyce GF. DNA-carbohydrate interactions. Specific binding of the calicheamicin γ1 I oligosaccharide with duplex DNA Journal of the American Chemical Society. 114: 7555-7557.  1
1991 Joyce GF. RNA today New Biologist. 3: 565-569. PMID 1716983  1
1991 Joyce GF. The rise and fall of the RNA world New Biologist. 3: 399-407. PMID 1712228  1
1990 Beaudry AA, Joyce GF. Minimum secondary structure requirements for catalytic activity of a self-splicing group I intron Biochemistry. 29: 6534-6539. PMID 2207095 DOI: 10.1021/Bi00479A027  1
1990 Robertson DL, Joyce GF. Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA Nature. 344: 467-468. PMID 1690861 DOI: 10.1038/344467A0  1
1990 Joyce GF. In the beginning Nature. 346: 806-806. DOI: 10.1038/346806a0  0.01
1989 Joyce GF. Amplification, mutation and selection of catalytic RNA Gene. 82: 83-87. PMID 2684778 DOI: 10.1016/0378-1119(89)90033-4  1
1989 Joyce GF, van der Horst G, Inoue T. Catalytic activity is retained in the Tetrahymena group I intron despite removal of the large extension of element P5 Nucleic Acids Research. 17: 7879-7889. PMID 2477801 DOI: 10.1093/Nar/17.19.7879  1
1989 Joyce GF. RNA evolution and the origins of life Nature. 338: 217-224. PMID 2466202 DOI: 10.1038/338217A0  1
1989 Joyce GF, Inoue T. A novel technique for the rapid preparation of mutant RNAs Nucleic Acids Research. 17: 711-722. PMID 2464798  1
1989 Joyce GF. Evolution of catalytic rna in the laboratory Origins of Life and Evolution of the Biosphere. 19: 331-331. DOI: 10.1007/Bf02388876  1
1988 Joyce GF, Orgel LE. Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C,A) templates. Journal of Molecular Biology. 202: 677-81. PMID 2459395 DOI: 10.1016/0022-2836(88)90297-5  1
1988 Joyce G. Hydrothermal vents too hot Nature. 334: 564-564. DOI: 10.1038/334564A0  0.01
1988 Joyce GF. Energy and the evolution of life Cell. 54: 289-290. DOI: 10.1016/0092-8674(88)90191-2  0.01
1987 Joyce GF, Inoue T. Structure of the catalytic core of the tetrahymena ribozyme as indicated by reactive abbreviated forms of the molecule Nucleic Acids Research. 15: 9825-9840. PMID 3697083 DOI: 10.1093/Nar/15.23.9825  1
1987 Joyce GF. Nonenzymatic template-directed synthesis of informational macromolecules Cold Spring Harbor Symposia On Quantitative Biology. 52: 41-51. PMID 2456883 DOI: 10.1101/Sqb.1987.052.01.008  1
1987 Joyce GF, Schwartz AW, Miller SL, Orgel LE. The case for an ancestral genetic system involving simple analogues of the nucleotides. Proceedings of the National Academy of Sciences of the United States of America. 84: 4398-402. PMID 2440020 DOI: 10.1073/Pnas.84.13.4398  1
1986 Joyce GF, Orgel LE. Non-enzymic template-directed synthesis on RNA random copolymers. Poly(C, G) templates. Journal of Molecular Biology. 188: 433-41. PMID 2426455 DOI: 10.1016/0022-2836(86)90166-X  1
1986 Joyce GF, Orgel LE. Consequences of template self-structure in poly(C,G)-directed synthesis of oligo(G,C)s Origins of Life and Evolution of the Biosphere. 16: 458-458. DOI: 10.1007/Bf02422133  0.24
1986 Joyce GF, Orgel LE, Miller SL. Chiral selection in template-directed RNA synthesis and the case for a prochiral ancestor of RNA Origins of Life and Evolution of the Biosphere. 16: 445-445. DOI: 10.1007/Bf02422125  0.04
1985 Seifert DA, Hughes PL, Joyce GF. Concern over the standard of tuberculin testing in deer. New Zealand Veterinary Journal. 33: 40. PMID 16031146 DOI: 10.1080/00480169.1985.35152  1
1984 Joyce GF, Tschirgi RD. Automata simulation of the selection process. Bio Systems. 17: 65-72. PMID 6743795 DOI: 10.1016/0303-2647(84)90017-0  1
1984 Joyce GF, Visser GM, van Boeckel CA, van Boom JH, Orgel LE, van Westrenen J. Chiral selection in poly(C)-directed synthesis of oligo(G). Nature. 310: 602-4. PMID 6462250 DOI: 10.1038/310602A0  1
1984 Joyce GF. Non-enzymatic template-directed synthesis of RNA copolymers Origins of Life. 14: 613-620. PMID 6205345 DOI: 10.1007/Bf00933711  1
1984 Joyce GF, Inoue T, Orgel LE. Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates. Journal of Molecular Biology. 176: 279-306. PMID 6205154 DOI: 10.1016/0022-2836(84)90425-X  1
1984 Inoue T, Joyce GF, Grzeskowiak K, Orgel LE, Brown JM, Reese CB. Template-directed synthesis on the pentanucleotide CpCpGpCpC. Journal of Molecular Biology. 178: 669-76. PMID 6092644 DOI: 10.1016/0022-2836(84)90244-4  1
1983 Joyce GF. The instability of the autogen Journal of Molecular Evolution. 19: 192-194. PMID 6571221 DOI: 10.1007/Bf02300758  1
1981 Hughes PL, Joyce GF. Retinal disease in the N.Z. working dog. New Zealand Veterinary Journal. 29: 241. PMID 16030809 DOI: 10.1080/00480169.1981.34854  1
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