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Bryan Knuckley - Publications

Affiliations: 
Scripps Florida, Jupiter, FL, United States 
Area:
Protein arginine deiminase, bead based high throughput screen, serine hydrolase
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25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 DuBose MB, Sartawi T, Sawatzky TM, Causey CP, Rehman FK, Knuckley B. A peptoid-based inhibitor of Protein Arginine Methyltransferase 1 (PRMT1) induces apoptosis and autophagy in cancer cells. The Journal of Biological Chemistry. 102205. PMID 35764172 DOI: 10.1016/j.jbc.2022.102205  0.717
2020 Mann SA, DeMart MK, May B, Causey CP, Knuckley B. Histone H4-based peptoids are inhibitors of Protein Arginine Methyltransferase 1 (PRMT1). The Biochemical Journal. PMID 32716034 DOI: 10.1042/Bcj20200534  0.739
2019 Mann SA, Salsburg A, Causey CP, Knuckley B. The development and characterization of a chemical probe targeting PRMT1 over PRMT5. Bioorganic & Medicinal Chemistry. 27: 224-229. PMID 30529151 DOI: 10.1016/J.Bmc.2018.12.001  0.721
2016 Soares CA, Knuckley B. Mechanistic studies of the agmatine deiminase from Listeria monocytogenes. The Biochemical Journal. 473: 1553-61. PMID 27034081 DOI: 10.1042/Bcj20160221  0.427
2015 James ED, Knuckley B, Alqahtani N, Porwal S, Ban J, Karty JA, Viswanathan R, Lane AL. Two distinct cyclodipeptide synthases from a marine actinomycete catalyze biosynthesis of the same diketopiperazine natural product. Acs Synthetic Biology. PMID 26641496 DOI: 10.1021/Acssynbio.5B00120  0.393
2015 Nguyen HC, Wang M, Salsburg A, Knuckley B. Development of a Plate-Based Screening Assay to Investigate the Substrate Specificity of the PRMT Family of Enzymes. Acs Combinatorial Science. PMID 26252756 DOI: 10.1021/Acscombsci.5B00070  0.39
2015 Marchenko M, Thomson A, Ellis TN, Knuckley B, Causey CP. Development of a clickable activity-based protein profiling (ABPP) probe for agmatine deiminases. Bioorganic & Medicinal Chemistry. 23: 2159-67. PMID 25819331 DOI: 10.1016/J.Bmc.2015.03.013  0.727
2014 Thomson A, O'Connor S, Knuckley B, Causey CP. Design, synthesis, and in vitro evaluation of an activity-based protein profiling (ABPP) probe targeting agmatine deiminases. Bioorganic & Medicinal Chemistry. 22: 4602-8. PMID 25127464 DOI: 10.1016/J.Bmc.2014.07.028  0.731
2014 Dreyton CJ, Knuckley B, Jones JE, Lewallen DM, Thompson PR. Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism. Biochemistry. 53: 4426-33. PMID 24989433 DOI: 10.1021/Bi500554B  0.75
2012 Lewallen DM, Steckler CJ, Knuckley B, Chalmers MJ, Thompson PR. Probing adenylation: Using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates Molecular Biosystems. 8: 1701-1706. PMID 22456874 DOI: 10.1039/C2Mb25053E  0.536
2012 Dwivedi N, Upadhyay J, Neeli I, Khan S, Pattanaik D, Myers L, Kirou KA, Hellmich B, Knuckley B, Thompson PR, Crow MK, Mikuls TR, Csernok E, Radic M. Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps. Arthritis and Rheumatism. 64: 982-992. PMID 22034172 DOI: 10.1002/Art.33432  0.453
2011 Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y, Hashimoto H, Sato M, Hofseth LJ, Thompson PR. The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. Journal of Medicinal Chemistry. 54: 6919-35. PMID 21882827 DOI: 10.1021/Jm2008985  0.746
2011 Chumanevich AA, Causey CP, Knuckley BA, Jones JE, Poudyal D, Chumanevich AP, Davis T, Matesic LE, Thompson PR, Hofseth LJ. Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G929-38. PMID 21415415 DOI: 10.1152/Ajpgi.00435.2010  0.742
2011 Willis VC, Gizinski AM, Banda NK, Causey CP, Knuckley B, Cordova KN, Luo Y, Levitt B, Glogowska M, Chandra P, Kulik L, Robinson WH, Arend WP, Thompson PR, Holers VM. N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. Journal of Immunology (Baltimore, Md. : 1950). 186: 4396-404. PMID 21346230 DOI: 10.4049/Jimmunol.1001620  0.759
2011 Taki H, Gomi T, Knuckley B, Thompson PR, Vugrek O, Hirata K, Miyahara T, Shinoda K, Hounoki H, Sugiyama E, Usui I, Urakaze M, Tobe K, Ishimoto T, Inoue R, et al. Purification of enzymatically inactive peptidylarginine deiminase type 6 from mouse ovary that reveals hexameric structure different from other dimeric isoforms Advances in Bioscience and Biotechnology. 2: 304-310. DOI: 10.4236/Abb.2011.24044  0.571
2010 Knuckley B, Jones JE, Bachovchin DA, Slack J, Causey CP, Brown SJ, Rosen H, Cravatt BF, Thompson PR. A fluopol-ABPP HTS assay to identify PAD inhibitors. Chemical Communications (Cambridge, England). 46: 7175-7. PMID 20740228 DOI: 10.1039/C0Cc02634D  0.756
2010 Knuckley B, Causey CP, Jones JE, Bhatia M, Dreyton CJ, Osborne TC, Takahara H, Thompson PR. Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3. Biochemistry. 49: 4852-63. PMID 20469888 DOI: 10.1021/Bi100363T  0.783
2010 Jones JE, Causey CP, Lovelace L, Knuckley B, Flick H, Lebioda L, Thompson PR. Characterization and inactivation of an agmatine deiminase from Helicobacter pylori. Bioorganic Chemistry. 38: 62-73. PMID 20036411 DOI: 10.1016/J.Bioorg.2009.11.004  0.749
2010 Knuckley B, Causey CP, Pellechia PJ, Cook PF, Thompson PR. Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): Evidence that general acid catalysis promotes efficient inactivation Chembiochem. 11: 161-165. PMID 20014086 DOI: 10.1002/Cbic.200900698  0.771
2009 Jones JE, Causey CP, Knuckley B, Slack-Noyes JL, Thompson PR. Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential Current Opinion in Drug Discovery and Development. 12: 616-627. PMID 19736621  0.752
2008 Knuckley B, Luo Y, Thompson PR. Profiling Protein Arginine Deiminase 4 (PAD4): A novel screen to identify PAD4 inhibitors Bioorganic and Medicinal Chemistry. 16: 739-745. PMID 17964793 DOI: 10.1016/J.Bmc.2007.10.021  0.598
2007 Knuckley B, Bhatia M, Thompson PR. Protein arginine deiminase 4: Evidence for a reverse protonation mechanism Biochemistry. 46: 6578-6587. PMID 17497940 DOI: 10.1021/Bi700095S  0.634
2006 Luo Y, Knuckley B, Bhatia M, Pellechia PJ, Thompson PR. Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): Synthesis and in vitro evaluation of a fluorescently labeled probe Journal of the American Chemical Society. 128: 14468-14469. PMID 17090024 DOI: 10.1021/Ja0656907  0.6
2006 Luo Y, Arita K, Bhatia M, Knuckley B, Lee YH, Stallcup MR, Sato M, Thompson PR. Inhibitors and inactivators of protein arginine deiminase 4: Functional and structural characterization Biochemistry. 45: 11727-11736. PMID 17002273 DOI: 10.1021/Bi061180D  0.615
2006 Luo Y, Knuckley B, Lee YH, Stallcup MR, Thompson PR. A fluoroacetamidine-based inactivator of protein arginine deiminase 4: Design, synthesis, and in vitro and in vivo evaluation Journal of the American Chemical Society. 128: 1092-1093. PMID 16433522 DOI: 10.1021/Ja0576233  0.605
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