Kevan Michael Shokat - Publications

Affiliations: 
1994-1999 Chemistry and Molecular Biology Princeton University, Princeton, NJ 
 1999- Chemistry University of California, Berkeley, Berkeley, CA 
 1999- Cellular and Molecular Pharmacology University of California, San Francisco, San Francisco, CA 
Area:
Chemical Biology, Kinases, Gtpases, drug discovery
Website:
http://chemistry.berkeley.edu/faculty/chem/shokat

331 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Loonat AA, Martin ED, Sarafraz-Shekary N, Tilgner K, Hertz NT, Levin R, Shokat KM, Burlingame AL, Arabacilar P, Uddin S, Thomas M, Marber MS, Clark JE. p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701545R. PMID 31638431 DOI: 10.1096/fj.201701545R  1
2019 Zhang Z, Shokat KM. Bifunctional Small-Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins. Angewandte Chemie (International Ed. in English). PMID 31557383 DOI: 10.1002/anie.201910124  0.76
2019 Lou K, Gilbert LA, Shokat KM. A Bounty of New Challenging Targets in Oncology for Chemical Discovery. Biochemistry. PMID 31343870 DOI: 10.1021/acs.biochem.9b00570  0.6
2019 Lou K, Steri V, Ge AY, Hwang YC, Yogodzinski CH, Shkedi AR, Choi ALM, Mitchell DC, Swaney DL, Hann B, Gordan JD, Shokat KM, Gilbert LA. KRAS inhibition produces a driver-limited state revealing collateral dependencies. Science Signaling. 12. PMID 31138768 DOI: 10.1126/scisignal.aaw9450  0.6
2019 Hernández-Ortega S, Sánchez-Botet A, Quandt E, Masip N, Gasa L, Verde G, Jiménez J, Levin RS, Rutaganira FU, Burlingame AL, Wolfgeher D, Ribeiro MPC, Kron SJ, Shokat KM, Clotet J. Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex. Experimental & Molecular Medicine. 51: 44. PMID 30992425 DOI: 10.1038/s12276-019-0242-2  1
2019 Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, Mukherjee S. A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis. Cell Host & Microbe. PMID 30827827 DOI: 10.1016/j.chom.2019.01.006  0.56
2019 Katsuno Y, Meyer DS, Zhang Z, Shokat KM, Akhurst RJ, Miyazono K, Derynck R. Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition. Science Signaling. 12. PMID 30808819 DOI: 10.1126/scisignal.aau8544  0.76
2019 Wong AW, Urisman A, Burlingame AL, Shokat KM. Chemically reprogramming the phospho-transfer reaction to crosslink protein kinases to their substrates. Protein Science : a Publication of the Protein Society. PMID 30636329 DOI: 10.1002/pro.3570  1
2018 Chamberlain CE, German MS, Yang K, Wang J, VanBrocklin H, Regan M, Shokat KM, Ducker GS, Kim GE, Hann B, Donner DB, Warren RS, Venook AP, Bergsland EK, Lee D, et al. A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-Resistant Tumors. Molecular Cancer Therapeutics. PMID 30254185 DOI: 10.1158/1535-7163.MCT-17-1204  0.76
2018 Ocasio CA, Warkentin AA, McIntyre PJ, Barkovich KJ, Vesely C, Spencer J, Shokat KM, Bayliss R. Type II kinase inhibitors targeting Cys-gatekeeper kinases display orthogonality with wild type and Ala/Gly-gatekeeper kinases. Acs Chemical Biology. PMID 30239186 DOI: 10.1021/acschembio.8b00592  1
2018 Chorba JS, Galvan AM, Shokat KM. A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9. Journal of Visualized Experiments : Jove. PMID 30222160 DOI: 10.3791/58265  1
2018 Barkovich KJ, Moore MK, Hu Q, Shokat KM. Chemical genetic inhibition of DEAD-box proteins using covalent complementarity. Nucleic Acids Research. PMID 30102385 DOI: 10.1093/nar/gky706  1
2018 Donnella HJ, Webber JT, Levin RS, Camarda R, Momcilovic O, Bayani N, Shah KN, Korkola JE, Shokat KM, Goga A, Gordan JD, Bandyopadhyay S. Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer. Nature Chemical Biology. PMID 29942081 DOI: 10.1038/s41589-018-0081-9  1
2018 Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP. Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy. Plos One. 13: e0193849. PMID 29799846 DOI: 10.1371/journal.pone.0193849  0.68
2018 Chorba JS, Galvan AM, Shokat KM. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. The Journal of Biological Chemistry. 293: 6692. PMID 29728531 DOI: 10.1074/jbc.AAC118.003335  1
2018 Hu Q, Shokat KM. Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP. Cell. PMID 29628140 DOI: 10.1016/j.cell.2018.03.018  0.96
2018 Nnadi CI, Jenkins ML, Gentile DR, Bateman LA, Zaidman D, Balius TE, Nomura DK, Burke JE, Shokat KM, London N. Novel K-Ras G12C Switch-II covalent binders destabilize Ras and accelerate nucleotide exchange. Journal of Chemical Information and Modeling. PMID 29320178 DOI: 10.1021/acs.jcim.7b00399  1
2017 Chorba JS, Galvan AM, Shokat KM. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. The Journal of Biological Chemistry. PMID 29259136 DOI: 10.1074/jbc.RA117.000754  1
2017 Gentile DR, Rathinaswamy MK, Jenkins ML, Moss SM, Siempelkamp BD, Renslo AR, Burke JE, Shokat KM. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. Cell Chemical Biology. PMID 29033317 DOI: 10.1016/j.chembiol.2017.08.025  1
2017 Rutaganira FU, Barks J, Dhason MS, Wang Q, Lopez MS, Long S, Radke JB, Jones NG, Maddirala AR, Janetka JW, El Bakkouri M, Hui R, Shokat KM, Sibley LD. Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii. Journal of Medicinal Chemistry. PMID 28933846 DOI: 10.1021/acs.jmedchem.7b01192  1
2017 Morisot N, Novotny CJ, Shokat KM, Ron D. A new generation of mTORC1 inhibitor attenuates alcohol intake and reward in mice. Addiction Biology. PMID 28681511 DOI: 10.1111/adb.12528  1
2017 McGregor LM, Jenkins ML, Kerwin C, Burke JE, Shokat KM. Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes. Biochemistry. PMID 28621541 DOI: 10.1021/acs.biochem.7b00271  1
2017 Plenker D, Riedel M, Brägelmann J, Dammert MA, Chauhan R, Knowles PP, Lorenz C, Keul M, Bührmann M, Pagel O, Tischler V, Scheel AH, Schütte D, Song Y, Stark J, ... ... Shokat KM, et al. Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors. Science Translational Medicine. 9. PMID 28615362 DOI: 10.1126/scitranslmed.aah6144  0.84
2017 Hoppmann C, Wong A, Yang B, Li S, Hunter T, Shokat KM, Wang L. Site-specific incorporation of phosphotyrosine using an expanded genetic code. Nature Chemical Biology. PMID 28604697 DOI: 10.1038/nchembio.2406  0.76
2017 Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. The Journal of Clinical Investigation. 127: 2438. PMID 28569734 DOI: 10.1172/JCI95182  1
2017 Novotny CJ, Hamilton GL, McCormick F, Shokat K. Farnesyltransferase-mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras. Acs Chemical Biology. PMID 28530791 DOI: 10.1021/acschembio.7b00374  1
2017 Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat KM, Nakamura K. Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease. Neurochemistry International. PMID 28434973 DOI: 10.1016/j.neuint.2017.04.006  1
2017 Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA. A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. Cancer Cell. 31: 424-435. PMID 28292440 DOI: 10.1016/j.ccell.2017.01.014  1
2017 Reed DE, Shokat KM. INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC. Molecular Cancer Research : McR. PMID 28196852 DOI: 10.1158/1541-7786.MCR-16-0183  0.96
2017 Uchida Y, Rutaganira FU, Jullié D, Shokat KM, von Zastrow M. Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling. Molecular Pharmacology. 91: 65-73. PMID 27821547 DOI: 10.1124/mol.116.106252  1
2017 Lazarus MB, Levin RS, Shokat KM. Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response. Cellular Signalling. 29: 78-83. PMID 27760376 DOI: 10.1016/j.cellsig.2016.10.006  1
2017 Jo A, Choi TG, Jo YH, Jyothi KR, Nguyen MN, Kim JH, Lim S, Shahid M, Akter S, Lee S, Lee KH, Kim W, Cho H, Lee J, Shokat KM, et al. Inhibition of Carbonyl Reductase 1 Safely Improves the Efficacy of Doxorubicin in Breast Cancer Treatment. Antioxidants & Redox Signaling. 26: 70-83. PMID 27357096 DOI: 10.1089/ars.2015.6457  0.56
2016 Urisman A, Levin RS, Gordan JD, Webber JT, Hernandez H, Ishihama Y, Shokat KM, Burlingame AL. An optimized chromatographic strategy for multiplexing in parallel reaction monitoring mass spectrometry: Insights from quantitation of activated kinases. Molecular & Cellular Proteomics : McP. PMID 27940637 DOI: 10.1074/mcp.M116.058172  1
2016 Novotny CJ, Pollari S, Park JH, Lemmon MA, Shen W, Shokat KM. Overcoming resistance to HER2 inhibitors through state-specific kinase binding. Nature Chemical Biology. 12: 923-930. PMID 27595329 DOI: 10.1038/nchembio.2171  1
2016 Levin RS, Hertz NT, Burlingame AL, Shokat KM, Mukherjee S. Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen. Proceedings of the National Academy of Sciences of the United States of America. 113: E4776-83. PMID 27482120 DOI: 10.1073/pnas.1608355113  1
2016 Ostrem JM, Shokat KM. Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design. Nature Reviews. Drug Discovery. 15: 771-785. PMID 27469033 DOI: 10.1038/nrd.2016.139  1
2016 Miller RE, Brough R, Bajrami I, Williamson CT, McDade S, Campbell J, Kigozi A, Rafiq R, Pemberton H, Natrajan R, Joel J, Astley H, Mahoney C, Moore JD, Torrance C, ... ... Shokat KM, et al. Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib. Molecular Cancer Therapeutics. 15: 1472-84. PMID 27364904 DOI: 10.1158/1535-7163.MCT-15-0554  1
2016 Rodrik-Outmezguine VS, Okaniwa M, Yao Z, Novotny CJ, McWhirter C, Banaji A, Won H, Wong W, Berger M, de Stanchina E, Barratt DG, Cosulich S, Klinowska T, Rosen N, Shokat KM. Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor. Nature. 534: 272-6. PMID 27279227 DOI: 10.1038/nature17963  1
2016 Saha SK, Gordan JD, Kleinstiver BP, Vu P, Najem MS, Yeo JC, Shi L, Kato Y, Levin RS, Webber JT, Damon LJ, Egan RK, Greninger P, McDermott U, Garnett MJ, ... ... Shokat KM, et al. Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. Cancer Discovery. 6: 727-39. PMID 27231123 DOI: 10.1158/2159-8290.CD-15-1442  1
2016 Tabaei SR, Guo F, Rutaganira FU, Vafaei S, Choong I, Shokat KM, Glenn JS, Cho NJ. Multistep Compositional Remodeling of Supported Lipid Membranes by Interfacially Active Phosphatidylinositol Kinases. Analytical Chemistry. 88: 5042-5. PMID 27118725 DOI: 10.1021/acs.analchem.6b01293  1
2016 Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, et al. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 29: 536-47. PMID 27050099 DOI: 10.1016/j.ccell.2016.03.001  0.48
2016 Rutaganira FU, Fowler ML, McPhail JA, Gelman MA, Nguyen K, Xiong A, Dornan GL, Tavshanjian B, Glenn JS, Shokat KM, Burke JE. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. Journal of Medicinal Chemistry. 59: 1830-9. PMID 26885694 DOI: 10.1021/acs.jmedchem.5b01311  1
2016 Fowler ML, McPhail JA, Jenkins ML, Masson GR, Rutaganira FU, Shokat KM, Williams RL, Burke JE. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11. Protein Science : a Publication of the Protein Society. 25: 826-39. PMID 26756197 DOI: 10.1002/pro.2879  1
2016 Sansó M, Levin RS, Lipp JJ, Wang VY, Greifenberg AK, Quezada EM, Ali A, Ghosh A, Larochelle S, Rana TM, Geyer M, Tong L, Shokat KM, Fisher RP. P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates. Genes & Development. 30: 117-31. PMID 26728557 DOI: 10.1101/gad.269589.115  1
2016 Floor SN, Barkovich KJ, Condon KJ, Shokat KM, Doudna JA. Analog sensitive chemical inhibition of the DEAD-box protein DDX3. Protein Science : a Publication of the Protein Society. 25: 638-49. PMID 26650549 DOI: 10.1002/pro.2857  0.6
2015 Kuhlenschmidt TB, Rutaganira FU, Long S, Tang K, Shokat KM, Kuhlenschmidt MS, Sibley LD. Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1) In Vitro by Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture. Antimicrobial Agents and Chemotherapy. 60: 570-9. PMID 26552986 DOI: 10.1128/AAC.01915-15  1
2015 Costa HA, Leitner MG, Sos ML, Mavrantoni A, Rychkova A, Johnson JR, Newton BW, Yee MC, De La Vega FM, Ford JM, Krogan NJ, Shokat KM, Oliver D, Halaszovich CR, Bustamante CD. Discovery and functional characterization of a neomorphic PTEN mutation. Proceedings of the National Academy of Sciences of the United States of America. 112: 13976-81. PMID 26504226 DOI: 10.1073/pnas.1422504112  1
2015 Schaffer BE, Levin RS, Hertz NT, Maures TJ, Schoof ML, Hollstein PE, Benayoun BA, Banko MR, Shaw RJ, Shokat KM, Brunet A. Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction. Cell Metabolism. 22: 907-21. PMID 26456332 DOI: 10.1016/j.cmet.2015.09.009  1
2015 Manz BN, Tan YX, Courtney AH, Rutaganira F, Palmer E, Shokat KM, Weiss A. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. 4. PMID 26302204 DOI: 10.7554/eLife.08088  0.56
2015 Lazarus MB, Shokat KM. Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1. Bioorganic & Medicinal Chemistry. 23: 5483-8. PMID 26275681 DOI: 10.1016/j.bmc.2015.07.034  1
2015 Lipp JJ, Marvin MC, Shokat KM, Guthrie C. SR protein kinases promote splicing of nonconsensus introns. Nature Structural & Molecular Biology. 22: 611-7. PMID 26167880 DOI: 10.1038/nsmb.3057  0.28
2015 Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I. WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science Signaling. 8: ra65. PMID 26126716 DOI: 10.1126/scisignal.aaa0354  0.52
2015 Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife. 4. PMID 25986605 DOI: 10.7554/eLife.05434  0.96
2015 Martin H, Shales M, Fernandez-Piñar P, Wei P, Molina M, Fiedler D, Shokat KM, Beltrao P, Lim W, Krogan NJ. Differential genetic interactions of yeast stress response MAPK pathways. Molecular Systems Biology. 11: 800. PMID 25888283  0.76
2015 Bailey FP, Byrne DP, Oruganty K, Eyers CE, Novotny CJ, Shokat KM, Kannan N, Eyers PA. The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner. The Biochemical Journal. 467: 47-62. PMID 25583260 DOI: 10.1042/BJ20141441  1
2015 Lazarus MB, Novotny CJ, Shokat KM. Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors. Acs Chemical Biology. 10: 257-61. PMID 25551253 DOI: 10.1021/cb500835z  1
2015 Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Molecular Cancer Therapeutics. 14: 419-28. PMID 25522764 DOI: 10.1158/1535-7163.MCT-14-0526  0.56
2015 Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, ... ... Shokat KM, et al. Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discovery. 5: 154-67. PMID 25501949 DOI: 10.1158/2159-8290.CD-14-0552  1
2015 Cage TA, Chanthery Y, Chesler L, Grimmer M, Knight Z, Shokat K, Weiss WA, Gustafson WC. Downregulation of MYCN through PI3K inhibition in mouse models of pediatric neural cancer Frontiers in Oncology. 5. DOI: 10.3389/fonc.2015.00111  1
2015 Martin H, Shales M, Fernandez-Piñar P, Wei P, Molina M, Fiedler D, Shokat KM, Beltrao P, Lim W, Krogan NJ. Differential genetic interactions of yeast stress response MAPK pathways Molecular Systems Biology. 11: 1-13. DOI: 10.15252/msb.20145606  1
2015 Li JJ, Cao C, Fixsen SM, Young JM, Ono C, Bando H, Elde NC, Katsuma S, Dever TE, Sicheri F, Shokat KM. Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe Proceedings of the National Academy of Sciences of the United States of America. 112: E4364-E4373. DOI: 10.1073/pnas.1505481112  1
2015 Lazarus MB, Novotny CJ, Shokat KM. Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors Acs Chemical Biology. 10: 257-261. DOI: 10.1021/cb500835z  1
2014 Warkentin AA, Lopez MS, Lasater EA, Lin K, He BL, Leung AY, Smith CC, Shah NP, Shokat KM. Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy. Elife. 3. PMID 25531068 DOI: 10.7554/eLife.03445  0.8
2014 Reed DE, Shokat KM. Targeting osteosarcoma. Proceedings of the National Academy of Sciences of the United States of America. 111: 18100-1. PMID 25512494 DOI: 10.1073/pnas.1420596111  0.96
2014 Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN. MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. Neuron. 84: 968-82. PMID 25456499 DOI: 10.1016/j.neuron.2014.10.025  0.6
2014 Lopez MS, Kliegman JI, Shokat KM. The logic and design of analog-sensitive kinases and their small molecule inhibitors. Methods in Enzymology. 548: 189-213. PMID 25399647 DOI: 10.1016/B978-0-12-397918-6.00008-2  1
2014 Chorba JS, Shokat KM. The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis. The Journal of Biological Chemistry. 289: 29030-43. PMID 25210046 DOI: 10.1074/jbc.M114.594861  1
2014 Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell. 26: 414-27. PMID 25175806 DOI: 10.1016/j.ccr.2014.07.015  1
2014 Mantilla CB, Stowe JM, Sieck DC, Ermilov LG, Greising SM, Zhang C, Shokat KM, Sieck GC. TrkB kinase activity maintains synaptic function and structural integrity at adult neuromuscular junctions. Journal of Applied Physiology (Bethesda, Md. : 1985). 117: 910-20. PMID 25170066 DOI: 10.1152/japplphysiol.01386.2013  1
2014 Parker N, Falk H, Singh D, Fidaleo A, Smith B, Lopez MS, Shokat KM, Wright WW. Responses to glial cell line-derived neurotrophic factor change in mice as spermatogonial stem cells form progenitor spermatogonia which replicate and give rise to more differentiated progeny. Biology of Reproduction. 91: 92. PMID 25165119 DOI: 10.1095/biolreprod.114.119099  1
2014 Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat KM, Ibanez CF. Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Elife. 3: e03245. PMID 25161195  1
2014 Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. 111: E3679-88. PMID 25136127 DOI: 10.1073/pnas.1413726111  1
2014 Sos ML, Levin RS, Gordan JD, Oses-Prieto JA, Webber JT, Salt M, Hann B, Burlingame AL, McCormick F, Bandyopadhyay S, Shokat KM. Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors. Cell Reports. 8: 1037-48. PMID 25127139 DOI: 10.1016/j.celrep.2014.07.010  1
2014 Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, ... ... Shokat KM, et al. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proceedings of the National Academy of Sciences of the United States of America. 111: 9983-8. PMID 24961373 DOI: 10.1073/pnas.1314939111  0.76
2014 Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nature Immunology. 15: 687-94. PMID 24908390 DOI: 10.1038/ni.2918  1
2014 Burke JE, Inglis AJ, Perisic O, Masson GR, McLaughlin SH, Rutaganira F, Shokat KM, Williams RL. Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors. Science (New York, N.Y.). 344: 1035-8. PMID 24876499 DOI: 10.1126/science.1253397  1
2014 Riel-Mehan MM, Shokat KM. A crosslinker based on a tethered electrophile for mapping kinase-substrate networks. Chemistry & Biology. 21: 585-90. PMID 24746561 DOI: 10.1016/j.chembiol.2014.02.022  1
2014 Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nature Immunology. 15: 186-94. PMID 24317039 DOI: 10.1038/ni.2772  1
2014 Davies JM, Robinson AE, Cowdrey C, Mummaneni PV, Ducker GS, Shokat KM, Bollen A, Hann B, Phillips JJ. Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. Journal of Neurosurgery. 120: 331-6. PMID 24286145 DOI: 10.3171/2013.10.JNS13598  0.68
2014 Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat KM, Warren RS. Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors. Oncogene. 33: 1590-600. PMID 23542178 DOI: 10.1038/onc.2013.92  1
2014 Reed DE, Shokat KM. Targeting osteosarcoma Proceedings of the National Academy of Sciences of the United States of America. 111: 18100-18101. DOI: 10.1073/pnas.1420596111  1
2013 Kliegman JI, Fiedler D, Ryan CJ, Xu YF, Su XY, Thomas D, Caccese MC, Cheng A, Shales M, Rabinowitz JD, Krogan NJ, Shokat KM. Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae. Cell Reports. 5: 1725-36. PMID 24360963 DOI: 10.1016/j.celrep.2013.11.040  1
2013 Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, et al. PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. Science Signaling. 6: ra105. PMID 24300897 DOI: 10.1126/scisignal.2004125  1
2013 Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 503: 548-51. PMID 24256730 DOI: 10.1038/nature12796  1
2013 Lopez MS, Choy JW, Peters U, Sos ML, Morgan DO, Shokat KM. Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. Journal of the American Chemical Society. 135: 18153-9. PMID 24171479 DOI: 10.1021/ja408704u  1
2013 Atreya CE, Sangale Z, Xu N, Matli MR, Tikishvili E, Welbourn W, Stone S, Shokat KM, Warren RS. PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival. Cancer Medicine. 2: 496-506. PMID 24156022 DOI: 10.1002/cam4.97  0.56
2013 Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA. EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. 24: 438-49. PMID 24135280 DOI: 10.1016/j.ccr.2013.09.004  1
2013 Hertz NT, Berthet A, Sos ML, Thorn KS, Burlingame AL, Nakamura K, Shokat KM. A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell. 154: 737-47. PMID 23953109 DOI: 10.1016/j.cell.2013.07.030  1
2013 Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM. Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. Acs Chemical Biology. 8: 1931-8. PMID 23841803 DOI: 10.1021/cb400376p  1
2013 Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proceedings of the National Academy of Sciences of the United States of America. 110: 11988-93. PMID 23803853 DOI: 10.1073/pnas.1310230110  0.68
2013 Schachter MM, Merrick KA, Larochelle S, Hirschi A, Zhang C, Shokat KM, Rubin SM, Fisher RP. A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression. Molecular Cell. 50: 250-60. PMID 23622515 DOI: 10.1016/j.molcel.2013.04.003  1
2013 Lourido S, Zhang C, Lopez MS, Tang K, Barks J, Wang Q, Wildman SA, Shokat KM, Sibley LD. Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. Journal of Medicinal Chemistry. 56: 3068-77. PMID 23470217 DOI: 10.1021/jm4001314  1
2013 Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptáček LJ, Fu YH. Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metabolism. 17: 291-302. PMID 23395175 DOI: 10.1016/j.cmet.2012.12.017  1
2012 Ducker GS, Atreya CE, Simko J, Nakakura EK, Bergsland EK, Donner DB, Shokat KM, Warren RS. Effect of PIK3CA and KRAS mutations on sensitivity to ATP-competitive mTOR inhibitors in a primary xenograft model of colorectal carcinoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 483. PMID 27982970 DOI: 10.1200/jco.2012.30.4_suppl.483  0.68
2012 Soskis MJ, Ho HY, Bloodgood BL, Robichaux MA, Malik AN, Ataman B, Rubin AA, Zieg J, Zhang C, Shokat KM, Sharma N, Cowan CW, Greenberg ME. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nature Neuroscience. 15: 1645-54. PMID 23143520 DOI: 10.1038/nn.3249  1
2012 Larochelle S, Amat R, Glover-Cutter K, Sansó M, Zhang C, Allen JJ, Shokat KM, Bentley DL, Fisher RP. Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II. Nature Structural & Molecular Biology. 19: 1108-15. PMID 23064645 DOI: 10.1038/nsmb.2399  1
2012 Wohlbold L, Merrick KA, De S, Amat R, Kim JH, Larochelle S, Allen JJ, Zhang C, Shokat KM, Petrini JH, Fisher RP. Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. Plos Genetics. 8: e1002935. PMID 22927831 DOI: 10.1371/journal.pgen.1002935  1
2012 Simon MD, Shokat KM. A method to site-specifically incorporate methyl-lysine analogues into recombinant proteins. Methods in Enzymology. 512: 57-69. PMID 22910202 DOI: 10.1016/B978-0-12-391940-3.00003-2  1
2012 Sansó M, Lee KM, Viladevall L, Jacques PÉ, Pagé V, Nagy S, Racine A, St Amour CV, Zhang C, Shokat KM, Schwer B, Robert F, Fisher RP, Tanny JC. A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. Plos Genetics. 8: e1002822. PMID 22876190 DOI: 10.1371/journal.pgen.1002822  1
2012 Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proceedings of the National Academy of Sciences of the United States of America. 109: 12722-7. PMID 22802621 DOI: 10.1073/pnas.1202492109  1
2012 Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D. Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing. The Journal of Clinical Investigation. 122: 2916-27. PMID 22772469 DOI: 10.1172/JCI60387  1
2012 Cibrián Uhalte E, Kirchner M, Hellwig N, Allen JJ, Donat S, Shokat KM, Selbach M, Abdelilah-Seyfried S. In vivo conditions to identify Prkci phosphorylation targets using the analog-sensitive kinase method in zebrafish. Plos One. 7: e40000. PMID 22768194 DOI: 10.1371/journal.pone.0040000  1
2012 Young ET, Zhang C, Shokat KM, Parua PK, Braun KA. The AMP-activated protein kinase Snf1 regulates transcription factor binding, RNA polymerase II activity, and mRNA stability of glucose-repressed genes in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 287: 29021-34. PMID 22761425 DOI: 10.1074/jbc.M112.380147  1
2012 Shokat KM. Profile of Kevan M. Shokat. Interview by Nicholette Zeliadt. Proceedings of the National Academy of Sciences of the United States of America. 109: 11057-11059. PMID 22753464 DOI: 10.1073/pnas.1209818109  1
2012 Jang M, Kim Y, Won H, Lim S, K R J, Dashdorj A, Min YH, Kim SY, Shokat KM, Ha J, Kim SS. Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Research. 72: 4214-24. PMID 22719067 DOI: 10.1158/0008-5472.CAN-12-1110  0.56
2012 Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, ... ... Shokat KM, et al. Hierarchical modularity and the evolution of genetic interactomes across species. Molecular Cell. 46: 691-704. PMID 22681890 DOI: 10.1016/j.molcel.2012.05.028  1
2012 Dar AC, Das TK, Shokat KM, Cagan RL. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 486: 80-4. PMID 22678283 DOI: 10.1038/nature11127  0.96
2012 Barkovich KJ, Hariono S, Garske AL, Zhang J, Blair JA, Fan QW, Shokat KM, Nicolaides T, Weiss WA. Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers. Cancer Discovery. 2: 450-7. PMID 22588882 DOI: 10.1158/2159-8290.CD-11-0287  1
2012 Sun Y, Miao Y, Yamane Y, Zhang C, Shokat KM, Takematsu H, Kozutsumi Y, Drubin DG. Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. Molecular Biology of the Cell. 23: 2388-98. PMID 22535525 DOI: 10.1091/mbc.E12-03-0209  1
2012 St Amour CV, Sansó M, Bösken CA, Lee KM, Larochelle S, Zhang C, Shokat KM, Geyer M, Fisher RP. Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition. Molecular and Cellular Biology. 32: 2372-83. PMID 22508988 DOI: 10.1128/MCB.06657-11  1
2012 Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ, Shokat KM, Fisher RP, Goga A. Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways. Proceedings of the National Academy of Sciences of the United States of America. 109: E1019-27. PMID 22474407 DOI: 10.1073/pnas.1111317109  1
2012 Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Neuron. 73: 1127-42. PMID 22445341 DOI: 10.1016/j.neuron.2012.01.019  1
2012 Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, ... ... Shokat KM, et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 485: 55-61. PMID 22367541 DOI: 10.1038/nature10912  1
2012 Atreya CE, Ducker GS, Feldman ME, Bergsland EK, Warren RS, Shokat KM. Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer. Investigational New Drugs. 30: 2219-25. PMID 22270257 DOI: 10.1007/s10637-012-9793-y  1
2012 Hengeveld RC, Hertz NT, Vromans MJ, Zhang C, Burlingame AL, Shokat KM, Lens SM. Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex. Molecular & Cellular Proteomics : McP. 11: 47-59. PMID 22267324 DOI: 10.1074/mcp.M111.013912  1
2012 Savitt J, Singh D, Zhang C, Chen LC, Folmer J, Shokat KM, Wright WW. The in vivo response of stem and other undifferentiated spermatogonia to the reversible inhibition of glial cell line-derived neurotrophic factor signaling in the adult. Stem Cells (Dayton, Ohio). 30: 732-40. PMID 22232066 DOI: 10.1002/stem.1028  1
2012 Statsuk AV, Shokat KM. Covalent cross-linking of kinases with their corresponding peptide substrates. Methods in Molecular Biology (Clifton, N.J.). 795: 179-90. PMID 21960223 DOI: 10.1007/978-1-61779-337-0_12  0.48
2012 Dorsey SG, Lovering RM, Renn CL, Leitch CC, Liu X, Tallon LJ, Sadzewicz LD, Pratap A, Ott S, Sengamalay N, Jones KM, Barrick C, Fulgenzi G, Becker J, Voelker K, ... ... Shokat K, et al. Genetic deletion of trkB.T1 increases neuromuscular function. American Journal of Physiology. Cell Physiology. 302: C141-53. PMID 21865582 DOI: 10.1152/ajpcell.00469.2010  1
2011 Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, Brunet A. Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Molecular Cell. 44: 878-92. PMID 22137581 DOI: 10.1016/j.molcel.2011.11.005  1
2011 Cipak L, Zhang C, Kovacikova I, Rumpf C, Miadokova E, Shokat KM, Gregan J. Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombe. Cell Cycle (Georgetown, Tex.). 10: 3527-32. PMID 22030861 DOI: 10.4161/cc.10.20.17792  1
2011 Artz JD, Wernimont AK, Allali-Hassani A, Zhao Y, Amani M, Lin YH, Senisterra G, Wasney GA, Fedorov O, King O, Roos A, Lunin VV, Qiu W, Finerty P, Hutchinson A, ... ... Shokat K, et al. The Cryptosporidium parvum kinome. Bmc Genomics. 12: 478. PMID 21962082 DOI: 10.1186/1471-2164-12-478  1
2011 Schoenborn JR, Tan YX, Zhang C, Shokat KM, Weiss A. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Science Signaling. 4: ra59. PMID 21917715 DOI: 10.1126/scisignal.2001893  1
2011 Wang BT, Ducker GS, Barczak AJ, Barbeau R, Erle DJ, Shokat KM. The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. Proceedings of the National Academy of Sciences of the United States of America. 108: 15201-6. PMID 21876130 DOI: 10.1073/pnas.1103746108  0.68
2011 Garske AL, Peters U, Cortesi AT, Perez JL, Shokat KM. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proceedings of the National Academy of Sciences of the United States of America. 108: 15046-52. PMID 21852571 DOI: 10.1073/pnas.1111239108  0.84
2011 Yoshii A, Murata Y, Kim J, Zhang C, Shokat KM, Constantine-Paton M. TrkB and protein kinase Mζ regulate synaptic localization of PSD-95 in developing cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 11894-904. PMID 21849550 DOI: 10.1523/JNEUROSCI.2190-11.2011  1
2011 Salomon D, Zhang C, Shokat KM, Sessa G. Sensitizing plant protein kinases to specific inhibition by ATP-competitive molecules. Methods in Molecular Biology (Clifton, N.J.). 779: 185-97. PMID 21837567 DOI: 10.1007/978-1-61779-264-9_10  1
2011 Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. Bmc Biology. 9: 48. PMID 21729334 DOI: 10.1186/1741-7007-9-48  1
2011 Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Structural and functional basis for RNA cleavage by Ire1. Bmc Biology. 9: 47. PMID 21729333 DOI: 10.1186/1741-7007-9-47  1
2011 Mirzoeva OK, Hann B, Hom YK, Debnath J, Aftab D, Shokat K, Korn WM. Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma Journal of Molecular Medicine. 89: 877-889. PMID 21678117 DOI: 10.1007/s00109-011-0774-y  1
2011 Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP. Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation. Molecular Cell. 42: 624-36. PMID 21658603 DOI: 10.1016/j.molcel.2011.03.031  1
2011 Dar AC, Shokat KM. The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling. Annual Review of Biochemistry. 80: 769-95. PMID 21548788 DOI: 10.1146/annurev-biochem-090308-173656  0.96
2011 Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature. 472: 366-9. PMID 21441910 DOI: 10.1038/nature09860  1
2011 Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Research. 71: 106-15. PMID 21199799 DOI: 10.1158/0008-5472.CAN-10-2732  1
2011 Tak E, Lee S, Lee J, Rashid MA, Kim YW, Park JH, Park WS, Shokat KM, Ha J, Kim SS. Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells. Journal of Hepatology. 54: 328-39. PMID 21056497 DOI: 10.1016/j.jhep.2010.06.045  0.56
2010 Hertz NT, Wang BT, Allen JJ, Zhang C, Dar AC, Burlingame AL, Shokat KM. Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry. Current Protocols in Chemical Biology. 2: 15-36. PMID 23836541 DOI: 10.1002/9780470559277.ch090201  1
2010 Bodenmiller B, Wanka S, Kraft C, Urban J, Campbell D, Pedrioli PG, Gerrits B, Picotti P, Lam H, Vitek O, Brusniak MY, Roschitzki B, Zhang C, Shokat KM, Schlapbach R, et al. Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Science Signaling. 3: rs4. PMID 21177495 DOI: 10.1126/scisignal.2001182  1
2010 Bandyopadhyay S, Mehta M, Kuo D, Sung MK, Chuang R, Jaehnig EJ, Bodenmiller B, Licon K, Copeland W, Shales M, Fiedler D, Dutkowski J, Guénolé A, van Attikum H, Shokat KM, et al. Rewiring of genetic networks in response to DNA damage. Science (New York, N.Y.). 330: 1385-9. PMID 21127252 DOI: 10.1126/science.1195618  1
2010 Chuluunbaatar U, Roller R, Feldman ME, Brown S, Shokat KM, Mohr I. Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication. Genes & Development. 24: 2627-39. PMID 21123650 DOI: 10.1101/gad.1978310  1
2010 Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Science Signaling. 3: ra81. PMID 21062993 DOI: 10.1126/scisignal.2001017  1
2010 Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nature Immunology. 11: 1085-92. PMID 21037577 DOI: 10.1038/ni.1955  1
2010 Su T, Bryant DM, Luton F, Vergés M, Ulrich SM, Hansen KC, Datta A, Eastburn DJ, Burlingame AL, Shokat KM, Mostov KE. A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nature Cell Biology. 12: 1143-53. PMID 21037565 DOI: 10.1038/ncb2118  1
2010 Chou WH, Wang D, McMahon T, Qi ZH, Song M, Zhang C, Shokat KM, Messing RO. GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13955-65. PMID 20962217 DOI: 10.1523/JNEUROSCI.0270-10.2010  1
2010 Gomez-Sjoberg R, Leyrat AA, Houseman BT, Shokat K, Quake SR. Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications. Analytical Chemistry. 82: 8954-60. PMID 20936785 DOI: 10.1021/ac101870s  0.76
2010 Tietjen JR, Zhang DW, Rodríguez-Molina JB, White BE, Akhtar MS, Heidemann M, Li X, Chapman RD, Shokat K, Keles S, Eick D, Ansari AZ. Chemical-genomic dissection of the CTD code Nature Structural and Molecular Biology. 17: 1154-1161. PMID 20802488 DOI: 10.1038/nsmb.1900  1
2010 Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. The Journal of Cell Biology. 190: 89-100. PMID 20624902 DOI: 10.1083/jcb.201001050  1
2010 Okuzumi T, Ducker GS, Zhang C, Aizenstein B, Hoffman R, Shokat KM. Synthesis and evaluation of indazole based analog sensitive Akt inhibitors. Molecular Biosystems. 6: 1389-402. PMID 20582381 DOI: 10.1039/c003917a  1
2010 Feldman ME, Shokat KM. New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs). Current Topics in Microbiology and Immunology. 347: 241-62. PMID 20549474 DOI: 10.1007/82_2010_64  1
2010 Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, Sibley LD. Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma. Nature. 465: 359-62. PMID 20485436 DOI: 10.1038/nature09022  1
2010 Sliedrecht T, Zhang C, Shokat KM, Kops GJ. Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. Plos One. 5: e10251. PMID 20422024 DOI: 10.1371/journal.pone.0010251  1
2010 Amin DN, Sergina N, Ahuja D, McMahon M, Blair JA, Wang D, Hann B, Koch KM, Shokat KM, Moasser MM. Resiliency and vulnerability in the HER2-HER3 tumorigenic driver. Science Translational Medicine. 2: 16ra7. PMID 20371474 DOI: 10.1126/scitranslmed.3000389  0.76
2010 Miller S, Tavshanjian B, Oleksy A, Perisic O, Houseman BT, Shokat KM, Williams RL. Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science (New York, N.Y.). 327: 1638-42. PMID 20339072 DOI: 10.1126/science.1184429  1
2010 Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D. mTOR complex-2 activates ENaC by phosphorylating SGK1. Journal of the American Society of Nephrology : Jasn. 21: 811-8. PMID 20338997 DOI: 10.1681/ASN.2009111168  1
2010 Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, Meyuhas O, Shokat KM, Ruggero D. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell. 17: 249-61. PMID 20227039 DOI: 10.1016/j.ccr.2010.01.021  1
2010 Williams O, Houseman BT, Kunkel EJ, Aizenstein B, Hoffman R, Knight ZA, Shokat KM. Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs. Chemistry & Biology. 17: 123-34. PMID 20189103 DOI: 10.1016/j.chembiol.2010.01.010  1
2010 Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature. 464: 427-30. PMID 20179705 DOI: 10.1038/nature08902  1
2010 An S, Kyoung M, Allen JJ, Shokat KM, Benkovic SJ. Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2. The Journal of Biological Chemistry. 285: 11093-9. PMID 20157113 DOI: 10.1074/jbc.M110.101139  1
2010 Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat KM, Shaw JP, et al. The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nature Chemical Biology. 6: 244. PMID 20154668 DOI: 10.1038/nchembio0310-244b  1
2010 Knight ZA, Lin H, Shokat KM. Targeting the cancer kinome through polypharmacology. Nature Reviews. Cancer. 10: 130-7. PMID 20094047 DOI: 10.1038/nrc2787  1
2010 Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat KM, Shaw JP, et al. The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nature Chemical Biology. 6: 117-24. PMID 20081827 DOI: 10.1038/nchembio.293  1
2010 Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF. Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. The Journal of Biological Chemistry. 285: 4278-90. PMID 19996317 DOI: 10.1074/jbc.M109.036731  1
2010 Carlson HK, Plate L, Price MS, Allen JJ, Shokat KM, Marletta MA. Use of a semisynthetic epitope to probe histidine kinase activity and regulation. Analytical Biochemistry. 397: 139-43. PMID 19819215 DOI: 10.1016/j.ab.2009.10.009  1
2010 Sliedrecht T, Zhang C, Shokat KM, Kops GJPL. Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in Mitosis Plos One. 5. DOI: 10.1371/journal.pone.0010251  1
2010 Shokat KM. A Drug-Drug Interaction Crystallizes a New Entry Point into the UPR Molecular Cell. 38: 161-163. DOI: 10.1016/j.molcel.2010.04.011  1
2009 Niu H, Wan L, Busygina V, Kwon Y, Allen JA, Li X, Kunz RC, Kubota K, Wang B, Sung P, Shokat KM, Gygi SP, Hollingsworth NM. Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation. Molecular Cell. 36: 393-404. PMID 19917248 DOI: 10.1016/j.molcel.2009.09.029  0.68
2009 Herbert SP, Huisken J, Kim TN, Feldman ME, Houseman BT, Wang RA, Shokat KM, Stainier DY. Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science (New York, N.Y.). 326: 294-8. PMID 19815777 DOI: 10.1126/science.1178577  1
2009 Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stückrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, ... ... Shokat KM, et al. Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proceedings of the National Academy of Sciences of the United States of America. 106: 18351-6. PMID 19805051 DOI: 10.1073/pnas.0907325106  0.96
2009 Liu Y, Warfield L, Zhang C, Luo J, Allen J, Lang WH, Ranish J, Shokat KM, Hahn S. Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. Molecular and Cellular Biology. 29: 4852-63. PMID 19581288 DOI: 10.1128/MCB.00609-09  1
2009 Beltrao P, Trinidad JC, Fiedler D, Roguev A, Lim WA, Shokat KM, Burlingame AL, Krogan NJ. Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. Plos Biology. 7: e1000134. PMID 19547744 DOI: 10.1371/journal.pbio.1000134  1
2009 Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. Plos Biology. 7: e1000111. PMID 19468302 DOI: 10.1371/journal.pbio.1000111  1
2009 Okuzumi T, Fiedler D, Zhang C, Gray DC, Aizenstein B, Hoffman R, Shokat KM. Inhibitor hijacking of Akt activation. Nature Chemical Biology. 5: 484-93. PMID 19465931 DOI: 10.1038/nchembio.183  1
2009 Justman QA, Serber Z, Ferrell JE, El-Samad H, Shokat KM. Tuning the activation threshold of a kinase network by nested feedback loops. Science (New York, N.Y.). 324: 509-12. PMID 19390045 DOI: 10.1126/science.1169498  0.44
2009 Salomon D, Bonshtien A, Mayrose M, Zhang C, Shokat KM, Sessa G. Bypassing kinase activity of the tomato Pto resistance protein with small molecule ligands. The Journal of Biological Chemistry. 284: 15289-98. PMID 19332544 DOI: 10.1074/jbc.M809724200  1
2009 Viladevall L, St Amour CV, Rosebrock A, Schneider S, Zhang C, Allen JJ, Shokat KM, Schwer B, Leatherwood JK, Fisher RP. TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. Molecular Cell. 33: 738-51. PMID 19328067 DOI: 10.1016/j.molcel.2009.01.029  1
2009 Niedermeier M, Hennessy BT, Knight ZA, Henneberg M, Hu J, Kurtova AV, Wierda WG, Keating MJ, Shokat KM, Burger JA. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood. 113: 5549-57. PMID 19318683 DOI: 10.1182/blood-2008-06-165068  1
2009 Fiedler D, Braberg H, Mehta M, Chechik G, Cagney G, Mukherjee P, Silva AC, Shales M, Collins SR, van Wageningen S, Kemmeren P, Holstege FC, Weissman JS, Keogh MC, Koller D, ... Shokat KM, et al. Functional organization of the S. cerevisiae phosphorylation network. Cell. 136: 952-63. PMID 19269370 DOI: 10.1016/j.cell.2008.12.039  1
2009 Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. Plos Biology. 7: e38. PMID 19209957 DOI: 10.1371/journal.pbio.1000038  1
2009 Wang H, Kakaradov B, Collins SR, Karotki L, Fiedler D, Shales M, Shokat KM, Walther TC, Krogan NJ, Koller D. A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Molecular & Cellular Proteomics : McP. 8: 1361-81. PMID 19176519 DOI: 10.1074/mcp.M800490-MCP200  1
2009 Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. EGFR signals to mTOR through PKC and independently of Akt in glioma. Science Signaling. 2: ra4. PMID 19176518 DOI: 10.1126/scisignal.2000014  1
2009 Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, ... ... Shokat KM, et al. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Research. 69: 565-72. PMID 19147570 DOI: 10.1158/0008-5472.CAN-08-3389  0.56
2009 Sly LM, Hamilton MJ, Kuroda E, Ho VW, Antignano FL, Omeis SL, van Netten-Thomas CJ, Wong D, Brugger HK, Williams O, Feldman ME, Houseman BT, Fiedler D, Shokat KM, Krystal G. SHIP prevents lipopolysaccharide from triggering an antiviral response in mice. Blood. 113: 2945-54. PMID 19139077 DOI: 10.1182/blood-2008-06-166082  1
2009 Li S, Makovets S, Matsuguchi T, Blethrow JD, Shokat KM, Blackburn EH. Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell. 136: 50-61. PMID 19135888 DOI: 10.1016/j.cell.2008.11.027  0.76
2009 Miller AL, Zhang C, Shokat KM, Lowell CA. Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 988-98. PMID 19124742  1
2009 Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P. The unfolded protein response signals through high-order assembly of Ire1. Nature. 457: 687-93. PMID 19079236 DOI: 10.1038/nature07661  1
2008 Morgan DJ, Weisenhaus M, Shum S, Su T, Zheng R, Zhang C, Shokat KM, Hille B, Babcock DF, McKnight GS. Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation. Proceedings of the National Academy of Sciences of the United States of America. 105: 20740-5. PMID 19074277 DOI: 10.1073/pnas.0810971105  1
2008 Merrick KA, Larochelle S, Zhang C, Allen JJ, Shokat KM, Fisher RP. Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells. Molecular Cell. 32: 662-72. PMID 19061641 DOI: 10.1016/j.molcel.2008.10.022  1
2008 Statsuk AV, Maly DJ, Seeliger MA, Fabian MA, Biggs WH, Lockhart DJ, Zarrinkar PP, Kuriyan J, Shokat KM. Tuning a three-component reaction for trapping kinase substrate complexes. Journal of the American Chemical Society. 130: 17568-74. PMID 19053485 DOI: 10.1021/ja807066f  1
2008 Zhang TT, Okkenhaug K, Nashed BF, Puri KD, Knight ZA, Shokat KM, Vanhaesebroeck B, Marshall AJ. Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. The Journal of Allergy and Clinical Immunology. 122: 811-819.e2. PMID 19014771 DOI: 10.1016/j.jaci.2008.08.008  1
2008 Choi DS, Wei W, Deitchman JK, Kharazia VN, Lesscher HM, McMahon T, Wang D, Qi ZH, Sieghart W, Zhang C, Shokat KM, Mody I, Messing RO. Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11890-9. PMID 19005054 DOI: 10.1523/JNEUROSCI.3156-08.2008  1
2008 Kang J, Yang M, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H. Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Molecular Cell. 32: 394-405. PMID 18995837 DOI: 10.1016/j.molcel.2008.09.017  1
2008 Shirra MK, McCartney RR, Zhang C, Shokat KM, Schmidt MC, Arndt KM. A chemical genomics study identifies Snf1 as a repressor of GCN4 translation. The Journal of Biological Chemistry. 283: 35889-98. PMID 18955495 DOI: 10.1074/jbc.M805325200  1
2008 Dar AC, Lopez MS, Shokat KM. Small molecule recognition of c-Src via the Imatinib-binding conformation. Chemistry & Biology. 15: 1015-22. PMID 18940662 DOI: 10.1016/j.chembiol.2008.09.007  1
2008 Chaisuparat R, Hu J, Jham BC, Knight ZA, Shokat KM, Montaner S. Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma. Cancer Research. 68: 8361-8. PMID 18922908 DOI: 10.1158/0008-5472.CAN-08-0878  1
2008 Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, Hoffman R, Williams RL, Shokat KM, Knight ZA. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nature Chemical Biology. 4: 691-9. PMID 18849971 DOI: 10.1038/nchembio.117  1
2008 Kurischko C, Kuravi VK, Wannissorn N, Nazarov PA, Husain M, Zhang C, Shokat KM, McCaffery JM, Luca FC. The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion. Molecular Biology of the Cell. 19: 5559-78. PMID 18843045 DOI: 10.1091/mbc.E08-05-0455  1
2008 Oda K, Okada J, Timmerman L, Rodriguez-Viciana P, Stokoe D, Shoji K, Taketani Y, Kuramoto H, Knight ZA, Shokat KM, McCormick F. PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation. Cancer Research. 68: 8127-36. PMID 18829572 DOI: 10.1158/0008-5472.CAN-08-0755  1
2008 Bateman RL, Rauh D, Tavshanjian B, Shokat KM. Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. The Journal of Biological Chemistry. 283: 35756-62. PMID 18826943 DOI: 10.1074/jbc.M807125200  0.96
2008 Kim JS, Lilley BN, Zhang C, Shokat KM, Sanes JR, Zhen M. A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation. Neural Development. 3: 23. PMID 18808695 DOI: 10.1186/1749-8104-3-23  1
2008 Lu X, Simon MD, Chodaparambil JV, Hansen JC, Shokat KM, Luger K. The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure. Nature Structural & Molecular Biology. 15: 1122-4. PMID 18794842 DOI: 10.1038/nsmb.1489  1
2008 Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. The Journal of Clinical Investigation. 118: 3038-50. PMID 18704194 DOI: 10.1172/JCI33337  1
2008 Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat KM. Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha. Cancer Cell. 14: 180-92. PMID 18691552 DOI: 10.1016/j.ccr.2008.06.014  1
2008 Johnson AW, Chen X, Crombag HS, Zhang C, Smith DR, Shokat KM, Gallagher M, Holland PC, Ginty DD. The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value. The European Journal of Neuroscience. 28: 997-1002. PMID 18671735 DOI: 10.1111/j.1460-9568.2008.06383.x  1
2008 Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D. Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. American Journal of Physiology. Renal Physiology. 295: F843-50. PMID 18653476 DOI: 10.1152/ajprenal.90348.2008  1
2008 Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, Proctor M, Shokat KM, Zhang C, Davis RW, Giaever G, St Onge RP, StOnge RP, Nislow C. An integrated platform of genomic assays reveals small-molecule bioactivities. Nature Chemical Biology. 4: 498-506. PMID 18622389 DOI: 10.1038/nchembio.100  1
2008 Kim HH, Abdelmohsen K, Lal A, Pullmann R, Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J, Shokat KM, Gorospe M. Nuclear HuR accumulation through phosphorylation by Cdk1. Genes & Development. 22: 1804-15. PMID 18593881 DOI: 10.1101/gad.1645808  0.92
2008 Sordet O, Larochelle S, Nicolas E, Stevens EV, Zhang C, Shokat KM, Fisher RP, Pommier Y. Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I. Journal of Molecular Biology. 381: 540-9. PMID 18588899 DOI: 10.1016/j.jmb.2008.06.028  1
2008 Park S, Chapuis N, Bardet V, Tamburini J, Gallay N, Willems L, Knight ZA, Shokat KM, Azar N, Viguié F, Ifrah N, Dreyfus F, Mayeux P, Lacombe C, Bouscary D. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. Leukemia. 22: 1698-706. PMID 18548104 DOI: 10.1038/leu.2008.144  1
2008 Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, Knight ZA, Cobb BS, Cantrell D, O'Connor E, Shokat KM, Fisher AG, Merkenschlager M. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proceedings of the National Academy of Sciences of the United States of America. 105: 7797-802. PMID 18509048 DOI: 10.1073/pnas.0800928105  1
2008 Torbett NE, Luna-Moran A, Knight ZA, Houk A, Moasser M, Weiss W, Shokat KM, Stokoe D. A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. The Biochemical Journal. 415: 97-110. PMID 18498248 DOI: 10.1042/BJ20080639  1
2008 Chen JS, Zhou LJ, Entin-Meer M, Yang X, Donker M, Knight ZA, Weiss W, Shokat KM, Haas-Kogan D, Stokoe D. Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Molecular Cancer Therapeutics. 7: 841-50. PMID 18413797 DOI: 10.1158/1535-7163.MCT-07-0393  1
2008 Levin SE, Zhang C, Kadlecek TA, Shokat KM, Weiss A. Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. The Journal of Biological Chemistry. 283: 15419-30. PMID 18378687 DOI: 10.1074/jbc.M709000200  1
2008 Wan L, Niu H, Futcher B, Zhang C, Shokat KM, Boulton SJ, Hollingsworth NM. Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. Genes & Development. 22: 386-97. PMID 18245450 DOI: 10.1101/gad.1626408  1
2008 Blethrow JD, Glavy JS, Morgan DO, Shokat KM. Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proceedings of the National Academy of Sciences of the United States of America. 105: 1442-7. PMID 18234856 DOI: 10.1073/pnas.0708966105  0.68
2008 Balla A, Kim YJ, Varnai P, Szentpetery Z, Knight Z, Shokat KM, Balla T. Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Molecular Biology of the Cell. 19: 711-21. PMID 18077555 DOI: 10.1091/mbc.E07-07-0713  0.36
2008 Rubenstein EM, McCartney RR, Zhang C, Shokat KM, Shirra MK, Arndt KM, Schmidt MC. Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. The Journal of Biological Chemistry. 283: 222-30. PMID 17991748 DOI: 10.1074/jbc.M707957200  1
2008 Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, Proctor M, Shokat KM, Zhang C, Davis RW, Giaever G, St Onge RP, Nislow C. An integrated platform of genomic assays reveals small-molecule bioactivities (Nature Chemical Biology (2008) 4, (498-506)) Nature Chemical Biology. 4: 632. DOI: 10.1038/nchembio1008-632  1
2008 Simon MD, Shokat KM. Engineering Control Over Protein Function Using Chemistry: Revealing Biological Specificity by Engineering Protein-Ligand Interactions Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 1: 115-139. DOI: 10.1002/9783527619375.ch3a  1
2007 Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chemistry & Biology. 14: 1261-72. PMID 18022565 DOI: 10.1016/j.chembiol.2007.09.011  1
2007 Weiss WA, Taylor SS, Shokat KM. Recognizing and exploiting differences between RNAi and small-molecule inhibitors. Nature Chemical Biology. 3: 739-44. PMID 18007642 DOI: 10.1038/nchembio1207-739  1
2007 Gregan J, Zhang C, Rumpf C, Cipak L, Li Z, Uluocak P, Nasmyth K, Shokat KM. Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe. Nature Protocols. 2: 2996-3000. PMID 18007635 DOI: 10.1038/nprot.2007.447  1
2007 Hung CH, Thomas L, Ruby CE, Atkins KM, Morris NP, Knight ZA, Scholz I, Barklis E, Weinberg AD, Shokat KM, Thomas G. HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. Cell Host & Microbe. 1: 121-33. PMID 18005690 DOI: 10.1016/j.chom.2007.03.004  1
2007 Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM, Walter P. IRE1 signaling affects cell fate during the unfolded protein response. Science (New York, N.Y.). 318: 944-9. PMID 17991856 DOI: 10.1126/science.1146361  1
2007 Knight ZA, Feldman ME, Balla A, Balla T, Shokat KM. A membrane capture assay for lipid kinase activity. Nature Protocols. 2: 2459-66. PMID 17947987 DOI: 10.1038/nprot.2007.361  1
2007 Bateman R, Rauh D, Shokat KM. Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct. Organic & Biomolecular Chemistry. 5: 3363-7. PMID 17912391 DOI: 10.1039/b707602a  0.96
2007 Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. A surface on the androgen receptor that allosterically regulates coactivator binding. Proceedings of the National Academy of Sciences of the United States of America. 104: 16074-9. PMID 17911242 DOI: 10.1073/pnas.0708036104  0.96
2007 Das M, Jiang F, Sluss HK, Zhang C, Shokat KM, Flavell RA, Davis RJ. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 15759-64. PMID 17893331 DOI: 10.1073/pnas.0707782104  1
2007 Qi ZH, Song M, Wallace MJ, Wang D, Newton PM, McMahon T, Chou WH, Zhang C, Shokat KM, Messing RO. Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. The Journal of Biological Chemistry. 282: 33052-63. PMID 17875639 DOI: 10.1074/jbc.M707233200  1
2007 Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA. A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Research. 67: 7960-5. PMID 17804702 DOI: 10.1158/0008-5472.CAN-07-2154  1
2007 Knight ZA, Garrison JL, Chan K, King DS, Shokat KM. A remodelled protease that cleaves phosphotyrosine substrates. Journal of the American Chemical Society. 129: 11672-3. PMID 17803306 DOI: 10.1021/ja073875n  1
2007 Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick SM, Shokat KM. A semisynthetic epitope for kinase substrates. Nature Methods. 4: 511-6. PMID 17486086 DOI: 10.1038/nmeth1048  1
2007 Kanin EI, Kipp RT, Kung C, Slattery M, Viale A, Hahn S, Shokat KM, Ansari AZ. Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 5812-7. PMID 17392431 DOI: 10.1073/pnas.0611505104  0.92
2007 Larochelle S, Merrick KA, Terret ME, Wohlbold L, Barboza NM, Zhang C, Shokat KM, Jallepalli PV, Fisher RP. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molecular Cell. 25: 839-50. PMID 17386261 DOI: 10.1016/j.molcel.2007.02.003  1
2007 Knight ZA, Shokat KM. Chemically targeting the PI3K family. Biochemical Society Transactions. 35: 245-9. PMID 17371250 DOI: 10.1042/BST0350245  1
2007 Burkard ME, Randall CL, Larochelle S, Zhang C, Shokat KM, Fisher RP, Jallepalli PV. Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 4383-8. PMID 17360533 DOI: 10.1073/pnas.0701140104  1
2007 Simon MD, Chu F, Racki LR, de la Cruz CC, Burlingame AL, Panning B, Narlikar GJ, Shokat KM. The site-specific installation of methyl-lysine analogs into recombinant histones. Cell. 128: 1003-12. PMID 17350582 DOI: 10.1016/j.cell.2006.12.041  1
2007 Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat KM. Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nature Chemical Biology. 3: 229-38. PMID 17334377 DOI: 10.1038/nchembio866  1
2007 Knight ZA, Shokat KM. Chemical genetics: where genetics and pharmacology meet. Cell. 128: 425-30. PMID 17289560 DOI: 10.1016/j.cell.2007.01.021  1
2007 Sergina NV, Rausch M, Wang D, Blair J, Hann B, Shokat KM, Moasser MM. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature. 445: 437-41. PMID 17206155 DOI: 10.1038/nature05474  0.76
2007 Zhang C, Shokat KM. Enhanced selectivity for inhibition of analog-sensitive protein kinases through scaffold optimization Tetrahedron. 63: 5832-5838. DOI: 10.1016/j.tet.2007.02.089  1
2006 Simon MD, Feldman ME, Rauh D, Maris AE, Wemmer DE, Shokat KM. Structure and properties of a re-engineered homeodomain protein-DNA interface. Acs Chemical Biology. 1: 755-60. PMID 17240973 DOI: 10.1021/cb6003756  1
2006 Allen JJ, Shokat KM. Chemical genomics: dialed in transcriptional network control with non-steroidal glucocorticoid receptor modulators. Acs Chemical Biology. 1: 139-40. PMID 17163659 DOI: 10.1021/cb600137r  1
2006 Wan L, Zhang C, Shokat KM, Hollingsworth NM. Chemical inactivation of cdc7 kinase in budding yeast results in a reversible arrest that allows efficient cell synchronization prior to meiotic recombination. Genetics. 174: 1767-74. PMID 17057233 DOI: 10.1534/genetics.106.064303  1
2006 Tóth B, Balla A, Ma H, Knight ZA, Shokat KM, Balla T. Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi. The Journal of Biological Chemistry. 281: 36369-77. PMID 17003043 DOI: 10.1074/jbc.M604935200  1
2006 Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat KM, Davis RJ. JNK2 is a positive regulator of the cJun transcription factor. Molecular Cell. 23: 899-911. PMID 16973441 DOI: 10.1016/j.molcel.2006.07.028  1
2006 Van Keymeulen A, Wong K, Knight ZA, Govaerts C, Hahn KM, Shokat KM, Bourne HR. To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. The Journal of Cell Biology. 174: 437-45. PMID 16864657 DOI: 10.1083/jcb.200604113  1
2006 Brodersen P, Petersen M, Bjørn Nielsen H, Zhu S, Newman MA, Shokat KM, Rietz S, Parker J, Mundy J. Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4. The Plant Journal : For Cell and Molecular Biology. 47: 532-46. PMID 16813576 DOI: 10.1111/j.1365-313X.2006.02806.x  0.32
2006 Wei F, Wang GD, Zhang C, Shokat KM, Wang H, Tsien JZ, Liauw J, Zhuo M. Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia. Molecular Pain. 2: 21. PMID 16776832 DOI: 10.1186/1744-8069-2-21  1
2006 Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 9: 341-9. PMID 16697955 DOI: 10.1016/j.ccr.2006.03.029  1
2006 Sturgeon CM, Knight ZA, Shokat KM, Roberge M. Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage. Molecular Cancer Therapeutics. 5: 885-92. PMID 16648558 DOI: 10.1158/1535-7163.MCT-05-0358  1
2006 Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 125: 733-47. PMID 16647110 DOI: 10.1016/j.cell.2006.03.035  1
2006 Kung C, Kenski DM, Krukenberg K, Madhani HD, Shokat KM. Selective kinase inhibition by exploiting differential pathway sensitivity. Chemistry & Biology. 13: 399-407. PMID 16632252 DOI: 10.1016/j.chembiol.2006.02.004  0.92
2006 Wohlbold L, Larochelle S, Liao JC, Livshits G, Singer J, Shokat KM, Fisher RP. The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity. Cell Cycle (Georgetown, Tex.). 5: 546-54. PMID 16552187 DOI: 10.4161/cc.5.5.2541  1
2006 Ventura JJ, Hübner A, Zhang C, Flavell RA, Shokat KM, Davis RJ. Chemical genetic analysis of the time course of signal transduction by JNK. Molecular Cell. 21: 701-10. PMID 16507367 DOI: 10.1016/j.molcel.2006.01.018  1
2006 Larochelle S, Batliner J, Gamble MJ, Barboza NM, Kraybill BC, Blethrow JD, Shokat KM, Fisher RP. Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nature Structural & Molecular Biology. 13: 55-62. PMID 16327805 DOI: 10.1038/nsmb1028  1
2006 Pinsky BA, Kung C, Shokat KM, Biggins S. The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores. Nature Cell Biology. 8: 78-83. PMID 16327780 DOI: 10.1038/ncb1341  0.92
2006 Knight ZA, Shokat KM. Knock-outs and inhibitors: One and the same? Blood. 107: 420-421. DOI: 10.1182/blood-2005-10-4264  1
2005 Dephoure N, Howson RW, Blethrow JD, Shokat KM, O'Shea EK. Combining chemical genetics and proteomics to identify protein kinase substrates. Proceedings of the National Academy of Sciences of the United States of America. 102: 17940-5. PMID 16330754 DOI: 10.1073/pnas.0509080102  0.68
2005 Kenski DM, Zhang C, von Zastrow M, Shokat KM. Chemical genetic engineering of G protein-coupled receptor kinase 2. The Journal of Biological Chemistry. 280: 35051-61. PMID 16081410 DOI: 10.1074/jbc.M507594200  1
2005 D'Aquino KE, Monje-Casas F, Paulson J, Reiser V, Charles GM, Lai L, Shokat KM, Amon A. The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Molecular Cell. 19: 223-34. PMID 16039591 DOI: 10.1016/j.molcel.2005.06.005  0.12
2005 Knight ZA, Shokat KM. Features of selective kinase inhibitors. Chemistry & Biology. 12: 621-37. PMID 15975507 DOI: 10.1016/j.chembiol.2005.04.011  1
2005 Cohen MS, Zhang C, Shokat KM, Taunton J. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science (New York, N.Y.). 308: 1318-21. PMID 15919995 DOI: 10.1126/science1108367  1
2005 Zhang C, Kenski DM, Paulson JL, Bonshtien A, Sessa G, Cross JV, Templeton DJ, Shokat KM. A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases. Nature Methods. 2: 435-41. PMID 15908922 DOI: 10.1038/nmeth764  1
2005 Shokat KM. Chemicals call bacteria, and a new membrane protein machine answers. Cell. 121: 163-6. PMID 15851024 DOI: 10.1016/j.cell.2005.04.007  0.01
2005 Allen JJ, Lazerwith SE, Shokat KM. Bio-orthogonal affinity purification of direct kinase substrates. Journal of the American Chemical Society. 127: 5288-9. PMID 15826144 DOI: 10.1021/ja050727t  1
2005 Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 46: 13-21. PMID 15820690 DOI: 10.1016/j.neuron.2005.03.009  1
2005 Tanaka M, Bateman R, Rauh D, Vaisberg E, Ramachandani S, Zhang C, Hansen KC, Burlingame AL, Trautman JK, Shokat KM, Adams CL. An unbiased cell morphology-based screen for new, biologically active small molecules. Plos Biology. 3: e128. PMID 15799708 DOI: 10.1371/journal.pbio.0030128  1
2005 Muratani M, Kung C, Shokat KM, Tansey WP. The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing. Cell. 120: 887-99. PMID 15797387 DOI: 10.1016/j.cell.2004.12.025  0.92
2005 Alaimo PJ, Knight ZA, Shokat KM. Targeting the gatekeeper residue in phosphoinositide 3-kinases. Bioorganic & Medicinal Chemistry. 13: 2825-36. PMID 15781393 DOI: 10.1016/j.bmc.2005.02.021  1
2005 Kung C, Kenski DM, Dickerson SH, Howson RW, Kuyper LF, Madhani HD, Shokat KM. Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 102: 3587-92. PMID 15738404 DOI: 10.1073/pnas.0407170102  0.92
2005 Kung C, Shokat KM. Small-molecule kinase-inhibitor target assessment. Chembiochem : a European Journal of Chemical Biology. 6: 523-6. PMID 15696508 DOI: 10.1002/cbic.200400393  0.92
2004 Blethrow J, Zhang C, Shokat KM, Weiss EL. Design and use of analog-sensitive protein kinases. Current Protocols in Molecular Biology. Unit 18.11. PMID 18265343 DOI: 10.1002/0471142727.mb1811s66  1
2004 Wong S, McLaughlin J, Cheng D, Zhang C, Shokat KM, Witte ON. Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations. Proceedings of the National Academy of Sciences of the United States of America. 101: 17456-61. PMID 15505216 DOI: 10.1073/pnas.0407061101  1
2004 Knight ZA, Chiang GG, Alaimo PJ, Kenski DM, Ho CB, Coan K, Abraham RT, Shokat KM. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorganic & Medicinal Chemistry. 12: 4749-59. PMID 15358300 DOI: 10.1016/j.bmc.2004.06.022  1
2004 Kunkel EJ, Plavec I, Nguyen D, Melrose J, Rosler ES, Kao LT, Wang Y, Hytopoulos E, Bishop AC, Bateman R, Shokat KM, Butcher EC, Berg EL. Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models. Assay and Drug Development Technologies. 2: 431-41. PMID 15357924 DOI: 10.1089/adt.2004.2.431  1
2004 Maly DJ, Allen JA, Shokat KM. A mechanism-based cross-linker for the identification of kinase-substrate pairs. Journal of the American Chemical Society. 126: 9160-1. PMID 15281787 DOI: 10.1021/ja048659i  1
2004 Sato K, Simon MD, Levin AM, Shokat KM, Weiss GA. Dissecting the Engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning. Chemistry & Biology. 11: 1017-23. PMID 15271360 DOI: 10.1016/j.chembiol.2004.05.008  1
2004 Simon MD, Sato K, Weiss GA, Shokat KM. A phage display selection of engrailed homeodomain mutants and the importance of residue Q50. Nucleic Acids Research. 32: 3623-31. PMID 15247345 DOI: 10.1093/nar/gkh690  1
2004 Simon MD, Shokat KM. Adaptability at a protein-DNA interface: re-engineering the engrailed homeodomain to recognize an unnatural nucleotide. Journal of the American Chemical Society. 126: 8078-9. PMID 15225024 DOI: 10.1021/ja048113w  1
2004 Provance DW, Gourley CR, Silan CM, Cameron LC, Shokat KM, Goldenring JR, Shah K, Gillespie PG, Mercer JA. Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic. Proceedings of the National Academy of Sciences of the United States of America. 101: 1868-73. PMID 14766983 DOI: 10.1073/pnas.0305895101  1
2004 Liu Y, Kung C, Fishburn J, Ansari AZ, Shokat KM, Hahn S. Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex. Molecular and Cellular Biology. 24: 1721-35. PMID 14749387  1
2004 Hindley AD, Park S, Wang L, Shah K, Wang Y, Hu X, Shokat KM, Kolch W, Sedivy JM, Yeung KC. Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position. Febs Letters. 556: 26-34. PMID 14706820  1
2003 Fan QW, Specht KM, Zhang C, Goldenberg DD, Shokat KM, Weiss WA. Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. Cancer Research. 63: 8930-8. PMID 14695210  1
2003 Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO. Targets of the cyclin-dependent kinase Cdk1. Nature. 425: 859-64. PMID 14574415 DOI: 10.1038/nature02062  1
2003 Sekiya-Kawasaki M, Groen AC, Cope MJ, Kaksonen M, Watson HA, Zhang C, Shokat KM, Wendland B, McDonald KL, McCaffery JM, Drubin DG. Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. The Journal of Cell Biology. 162: 765-72. PMID 12952930 DOI: 10.1083/jcb.200305077  1
2003 Knight ZA, Schilling B, Row RH, Kenski DM, Gibson BW, Shokat KM. Phosphospecific proteolysis for mapping sites of protein phosphorylation. Nature Biotechnology. 21: 1047-54. PMID 12923550 DOI: 10.1038/nbt863  1
2003 Sreenivasan A, Bishop AC, Shokat KM, Kellogg DR. Specific inhibition of Elm1 kinase activity reveals functions required for early G1 events. Molecular and Cellular Biology. 23: 6327-37. PMID 12917352  1
2003 Shah K, Shokat KM. A chemical genetic approach for the identification of direct substrates of protein kinases. Methods in Molecular Biology (Clifton, N.J.). 233: 253-71. PMID 12840513 DOI: 10.1385/1-59259-397-6:253  1
2003 Ulrich SM, Kenski DM, Shokat KM. Engineering a "methionine clamp" into Src family kinases enhances specificity toward unnatural ATP analogues. Biochemistry. 42: 7915-21. PMID 12834343 DOI: 10.1021/bi030042a  0.88
2003 Benjamin KR, Zhang C, Shokat KM, Herskowitz I. Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. Genes & Development. 17: 1524-39. PMID 12783856 DOI: 10.1101/gad.1101503  1
2003 Wang H, Shimizu E, Tang YP, Cho M, Kyin M, Zuo W, Robinson DA, Alaimo PJ, Zhang C, Morimoto H, Zhuo M, Feng R, Shokat KM, Tsien JZ. Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain. Proceedings of the National Academy of Sciences of the United States of America. 100: 4287-92. PMID 12646704 DOI: 10.1073/pnas.0636870100  1
2003 Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ. Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. The Journal of Biological Chemistry. 278: 14926-35. PMID 12594221 DOI: 10.1074/jbc.M300485200  1
2003 Abeliovich H, Zhang C, Dunn WA, Shokat KM, Klionsky DJ. Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Molecular Biology of the Cell. 14: 477-90. PMID 12589048 DOI: 10.1091/mbc.E02-07-0413  1
2002 Alaimo PJ, Shogren-Knaak MA, Shokat KM. Chemical Genetic Analysis of Protein Kinase Cascades. Thescientificworldjournal. 2: 108-110. PMID 29973826 DOI: 10.1100/tsw.2002.51  1
2002 Ulrich SM, Sallee NA, Shokat KM. Conformational restraint is a critical determinant of unnatural nucleotide recognition by protein kinases. Bioorganic & Medicinal Chemistry Letters. 12: 3223-7. PMID 12372539  0.88
2002 Kraybill BC, Elkin LL, Blethrow JD, Morgan DO, Shokat KM. Inhibitor scaffolds as new allele specific kinase substrates. Journal of the American Chemical Society. 124: 12118-28. PMID 12371851  0.68
2002 Buzko O, Shokat KM. A kinase sequence database: sequence alignments and family assignment. Bioinformatics (Oxford, England). 18: 1274-5. PMID 12217924  0.88
2002 Fan QW, Zhang C, Shokat KM, Weiss WA. Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling. Current Biology : Cb. 12: 1386-94. PMID 12194819  1
2002 Buzko OV, Bishop AC, Shokat KM. Modified AutoDock for accurate docking of protein kinase inhibitors. Journal of Computer-Aided Molecular Design. 16: 113-27. PMID 12188021  1
2002 Niswender CM, Ishihara RW, Judge LM, Zhang C, Shokat KM, McKnight GS. Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity. The Journal of Biological Chemistry. 277: 28916-22. PMID 12034735 DOI: 10.1074/jbc.M203327200  1
2002 Specht KM, Shokat KM. The emerging power of chemical genetics. Current Opinion in Cell Biology. 14: 155-9. PMID 11891113  1
2002 Holt JR, Gillespie SK, Provance DW, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PG. A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Cell. 108: 371-81. PMID 11853671 DOI: 10.1016/S0092-8674(02)00629-3  1
2002 Shah K, Shokat KM. A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. Chemistry & Biology. 9: 35-47. PMID 11841937  1
2002 Witucki LA, Huang X, Shah K, Liu Y, Kyin S, Eck MJ, Shokat KM. Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chemistry & Biology. 9: 25-33. PMID 11841936  1
2001 Ting AY, Witte K, Shah K, Kraybill B, Shokat KM, Schultz PG. Phage-display evolution of tyrosine kinases with altered nucleotide specificity. Biopolymers. 60: 220-8. PMID 11774228 DOI: 10.1002/1097-0282(2001)60:3<220::AID-BIP10035>3.0.CO;2-C  1
2001 Shogren-Knaak MA, Alaimo PJ, Shokat KM. Recent advances in chemical approaches to the study of biological systems. Annual Review of Cell and Developmental Biology. 17: 405-33. PMID 11687495 DOI: 10.1146/annurev.cellbio.17.1.405  1
2001 Carroll AS, Bishop AC, DeRisi JL, Shokat KM, O'Shea EK. Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response. Proceedings of the National Academy of Sciences of the United States of America. 98: 12578-83. PMID 11675494 DOI: 10.1073/pnas.211195798  1
2001 Alaimo PJ, Shogren-Knaak MA, Shokat KM. Chemical genetic approaches for the elucidation of signaling pathways. Current Opinion in Chemical Biology. 5: 360-7. PMID 11470597  1
2001 Bishop AC, Buzko O, Shokat KM. Magic bullets for protein kinases. Trends in Cell Biology. 11: 167-72. PMID 11306297  1
2001 Habelhah H, Shah K, Huang L, Burlingame AL, Shokat KM, Ronai Z. Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue. The Journal of Biological Chemistry. 276: 18090-5. PMID 11259409 DOI: 10.1074/jbc.M011396200  1
2001 Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, Hentze MW, Ronai Z. ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. Nature Cell Biology. 3: 325-30. PMID 11231586 DOI: 10.1038/35060131  1
2000 Liu Y, Witucki LA, Shah K, Bishop AC, Shokat KM. Src-Abl tyrosine kinase chimeras: replacement of the adenine binding pocket of c-Abl with v-Src to swap nucleotide and inhibitor specificities. Biochemistry. 39: 14400-8. PMID 11087392  1
2000 Weiss EL, Bishop AC, Shokat KM, Drubin DG. Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p. Nature Cell Biology. 2: 677-85. PMID 11025657 DOI: 10.1038/35036300  1
2000 Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J, Shimizu E, Tsien JZ, Schultz PG, Rose MD, Wood JL, Morgan DO, Shokat KM. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 407: 395-401. PMID 11014197 DOI: 10.1038/35030148  1
2000 Bishop A, Buzko O, Heyeck-Dumas S, Jung I, Kraybill B, Liu Y, Shah K, Ulrich S, Witucki L, Yang F, Zhang C, Shokat KM. Unnatural ligands for engineered proteins: new tools for chemical genetics. Annual Review of Biophysics and Biomolecular Structure. 29: 577-606. PMID 10940260 DOI: 10.1146/annurev.biophys.29.1.577  1
2000 Weintraub BC, Jun JE, Bishop AC, Shokat KM, Thomas ML, Goodnow CC. Entry of B cell receptor into signaling domains is inhibited in tolerant B cells. The Journal of Experimental Medicine. 191: 1443-8. PMID 10770810  1
2000 Armstrong JI, Portley AR, Chang YT, Nierengarten DM, Cook BN, Bowman KG, Bishop A, Gray NS, Shokat KM, Schultz PG, Bertozzi CR. Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library We thank Sharon Long and Dave Keating for providing both the NodH sulfotransferase and APS Kinase during our preliminary experiments and Jack Kirsch for numerous helpful conversations. J.I.A. and K.G.B were supported by NIH Molecular Biophysics Training Grant (No. T32GM0895). This research was funded by grants to C.R.B. from the Pew Scholars Program, the W. M. Keck Foundation and the American Cancer Society (Grant No. RPG9700501BE). Angewandte Chemie (International Ed. in English). 39: 1303-1306. PMID 10767039 DOI: 10.1002/(SICI)1521-3773(20000403)39:7<1303::AID-ANIE1303>3.0.CO;2-0  1
1999 Gillespie PG, Gillespie SK, Mercer JA, Shah K, Shokat KM. Engineering of the myosin-ibeta nucleotide-binding pocket to create selective sensitivity to N(6)-modified ADP analogs. The Journal of Biological Chemistry. 274: 31373-81. PMID 10531338 DOI: 10.1074/jbc.274.44.31373  1
1999 Buzko OV, Shokat KM. Blocking HIV entry. Nature Structural Biology. 6: 906-8. PMID 10504719 DOI: 10.1038/13266  1
1999 Liu Y, Bishop A, Witucki L, Kraybill B, Shimizu E, Tsien J, Ubersax J, Blethrow J, Morgan DO, Shokat KM. Structural basis for selective inhibition of Src family kinases by PP1. Chemistry & Biology. 6: 671-8. PMID 10467133 DOI: 10.1016/S1074-5521(99)80118-5  1
1999 Bishop AC, Shokat KM. Acquisition of inhibitor-sensitive protein kinases through protein design. Pharmacology & Therapeutics. 82: 337-46. PMID 10454210  1
1999 Yang F, Liu Y, Bixby SD, Friedman JD, Shokat KM. Highly efficient green fluorescent protein-based kinase substrates. Analytical Biochemistry. 266: 167-73. PMID 9888972 DOI: 10.1006/abio.1998.2885  1
1998 Liu Y, Shah K, Yang F, Witucki L, Shokat KM. A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src. Bioorganic & Medicinal Chemistry. 6: 1219-26. PMID 9784863  1
1998 Bishop AC, Shah K, Liu Y, Witucki L, Kung C, Shokat KM. Design of allele-specific inhibitors to probe protein kinase signaling. Current Biology : Cb. 8: 257-66. PMID 9501066  1
1998 Liu Y, Shah K, Yang F, Witucki L, Shokat KM. Engineering Src family protein kinases with unnatural nucleotide specificity. Chemistry & Biology. 5: 91-101. PMID 9495830  1
1997 Shah K, Liu Y, Deirmengian C, Shokat KM. Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proceedings of the National Academy of Sciences of the United States of America. 94: 3565-70. PMID 9108016  1
1995 Shokat KM, Goodnow CC. Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature. 375: 334-8. PMID 7753200 DOI: 10.1038/375334a0  1
1994 Cooke MP, Heath AW, Shokat KM, Zeng Y, Finkelman FD, Linsley PS, Howard M, Goodnow CC. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. The Journal of Experimental Medicine. 179: 425-38. PMID 8294858  1
1991 Shokat KM, Schultz PG. The generation of antibody combining sites containing catalytic residues. Ciba Foundation Symposium. 159: 118-28; discussion 1. PMID 1959444  1
1991 Shokat KM, Schultz PG. Catalytic antibodies. Methods in Enzymology. 203: 327-51. PMID 1762563  1
1990 Shokat KM, Schultz PG. Catalytic antibodies. Annual Review of Immunology. 8: 335-63. PMID 2188666 DOI: 10.1146/annurev.iy.08.040190.002003  1
1989 Shokat KM, Leumann CJ, Sugasawara R, Schultz PG. A new strategy for the generation of catalytic antibodies. Nature. 338: 269-71. PMID 2922053 DOI: 10.1038/338269a0  1
1987 McClard RW, Shokat KM. Does the bifunctional uridylate synthase channel orotidine 5'-phosphate? Kinetics of orotate phosphoribosyltransferase and orotidylate decarboxylase activities fit a noninteracting sites model. Biochemistry. 26: 3378-84. PMID 3651388  1
Show low-probability matches.