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Manoj Patel - Publications

Affiliations: 
University of Virginia, Charlottesville, VA 
Area:
Neuroscience Biology
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Burke CT, Vitko I, Straub J, Nylund EO, Gawda A, Blair K, Sullivan KA, Ergun L, Ottolini M, Patel MK, Perez-Reyes E. EpiPro, a Novel, Synthetic, Activity-Regulated Promoter That Targets Hyperactive Neurons in Epilepsy for Gene Therapy Applications. International Journal of Molecular Sciences. 24. PMID 37833914 DOI: 10.3390/ijms241914467  0.404
2023 Wenker IC, Patel MK. Waiting to Inhale: Preventing Fatality From Seizure-Induced Apnea. Epilepsy Currents. 23: 185-187. PMID 37334424 DOI: 10.1177/15357597231159466  0.438
2022 Miralles R, Patel MK. That's a Wrap: Could Controlling Activity-Regulated Myelination Prevent Absence Seizures? Epilepsy Currents. 22: 395-397. PMID 36426188 DOI: 10.1177/15357597221123898  0.344
2022 Wenker IC, Boscia AR, Lewis C, Tariq A, Miralles R, Hanflink JC, Saraf P, Patel MK. Forebrain epileptiform activity is not required for seizure-induced apnea in a mouse model of epilepsy. Frontiers in Neural Circuits. 16: 1002013. PMID 36160949 DOI: 10.3389/fncir.2022.1002013  0.491
2022 Wenker IC, Blizzard EA, Wagley PK, Patel MK. Peri-Ictal Autonomic Control of Cardiac Function and Seizure-Induced Death. Frontiers in Neuroscience. 15: 795145. PMID 35126041 DOI: 10.3389/fnins.2021.795145  0.437
2021 Miralles RM, Patel MK. It Takes Two to Tango: Channel Interplay Leads to Paradoxical Hyperexcitability in a Loss-of-Function Epilepsy Variant. Epilepsy Currents. 22: 69-71. PMID 35233206 DOI: 10.1177/15357597211057966  0.417
2021 Wengert ER, Patel MK. One Size Doesn't Fit All: Variant-Specific Effects in SCN8A Encephalopathy. Epilepsy Currents. 21: 183-185. PMID 34867099 DOI: 10.1177/15357597211002206  0.699
2021 Wengert ER, Patel MK. One Size Doesn't Fit All: Variant-Specific Effects in SCN8A Encephalopathy. Epilepsy Currents. 21: 183-185. PMID 34867099 DOI: 10.1177/15357597211002206  0.699
2021 Wengert ER, Wagley PK, Strohm SM, Reza N, Wenker IC, Gaykema RP, Christiansen A, Liau G, Patel MK. Targeted Augmentation of Nuclear Gene Output (TANGO) of SCN1A Rescues Parvalbumin Interneuron Excitability and Reduces Seizures in a Mouse Model of Dravet Syndrome. Brain Research. 147743. PMID 34843701 DOI: 10.1016/j.brainres.2021.147743  0.779
2021 Thompson JA, Miralles RM, Wengert ER, Wagley PK, Yu W, Wenker IC, Patel MK. Astrocyte Reactivity in a Mouse Model of SCN8A Epileptic Encephalopathy. Epilepsia Open. PMID 34826216 DOI: 10.1002/epi4.12564  0.797
2021 Wengert ER, Miralles RM, Wedgwood KCA, Wagley PK, Strohm SM, Panchal PS, Idrissi AM, Wenker IC, Thompson JA, Gaykema RP, Patel MK. Somatostatin-positive Interneurons Contribute to Seizures in Epileptic Encephalopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34544834 DOI: 10.1523/JNEUROSCI.0718-21.2021  0.802
2021 Wengert ER, Wenker IC, Wagner EL, Wagley PK, Gaykema RP, Shin JB, Patel MK. Adrenergic Mechanisms of Audiogenic Seizure-Induced Death in a Mouse Model of Encephalopathy. Frontiers in Neuroscience. 15: 581048. PMID 33762902 DOI: 10.3389/fnins.2021.581048  0.775
2021 Wenker IC, Teran FA, Wengert ER, Wagley PK, Panchal PS, Blizzard EA, Saraf P, Wagnon JL, Goodkin HP, Meisler MH, Richerson GB, Patel MK. Postictal death is associated with tonic phase apnea in a mouse model of SUDEP. Annals of Neurology. PMID 33604927 DOI: 10.1002/ana.26053  0.767
2020 Wengert ER, Patel MK. The Role of the Persistent Sodium Current in Epilepsy. Epilepsy Currents. 1535759720973978. PMID 33236643 DOI: 10.1177/1535759720973978  0.767
2019 Wengert ER, Tronhjem CE, Wagnon JL, Johannesen KM, Petit H, Krey I, Saga AU, Panchal PS, Strohm SM, Lange J, Kamphausen SB, Rubboli G, Lemke JR, Gardella E, Patel MK, et al. Biallelic inherited SCN8A variants, a rare cause of SCN8A-related developmental and epileptic encephalopathy. Epilepsia. PMID 31625145 DOI: 10.1111/Epi.16371  0.749
2019 Wengert ER, Saga AU, Panchal PS, Barker BS, Patel MK. Prax330 reduces persistent and resurgent sodium channel currents and neuronal hyperexcitability of subiculum neurons in a mouse model of SCN8A epileptic encephalopathy. Neuropharmacology. 107699. PMID 31278928 DOI: 10.1016/j.neuropharm.2019.107699  0.769
2019 Bunton-Stasyshyn RKA, Wagnon JL, Wengert ER, Barker BS, Faulkner A, Wagley PK, Bhatia K, Jones JM, Maniaci MR, Parent JM, Goodkin HP, Patel MK, Meisler MH. Prominent role of forebrain excitatory neurons in SCN8A encephalopathy. Brain : a Journal of Neurology. PMID 30601941 DOI: 10.1093/Brain/Awy324  0.79
2018 Baker EM, Thompson CH, Hawkins NA, Wagnon JL, Wengert ER, Patel MK, George AL, Meisler MH, Kearney JA. The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy. Epilepsia. PMID 29782051 DOI: 10.1111/Epi.14196  0.786
2018 Wagnon JL, Mencacci NE, Barker BS, Wenger ER, Bhatia KP, Balint B, Carecchio M, Wood NW, Patel MK, Meisler MH. Partial loss-of-function of sodium channel SCN8A in familial isolated myoclonus. Human Mutation. PMID 29726066 DOI: 10.1002/Humu.23547  0.424
2017 Barker BS, Nigam A, Ottolini M, Gaykema RP, Hargus NJ, Patel MK. Pro-excitatory alterations in sodium channel activity facilitate subiculum neuron hyperexcitability in temporal lobe epilepsy. Neurobiology of Disease. PMID 28860087 DOI: 10.1016/J.Nbd.2017.08.018  0.362
2017 Wagnon JL, Barker BS, Ottolini M, Park Y, Volkheimer A, Valdez P, Swinkels MEM, Patel MK, Meisler MH. Loss-of-function variants of SCN8A in intellectual disability without seizures. Neurology. Genetics. 3: e170. PMID 28702509 DOI: 10.1212/Nxg.0000000000000170  0.451
2017 Ottolini M, Barker BS, Gaykema RP, Meisler MH, Patel MK. Aberrant sodium channel currents and hyperexcitability of medial entorhinal cortex neurons in a mouse model of SCN8A encephalopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28676574 DOI: 10.1523/Jneurosci.2709-16.2017  0.535
2016 Barker BS, Ottolini M, Wagnon JL, Hollander RM, Meisler MH, Patel MK. The SCN8A encephalopathy mutation p.Ile1327Val displays elevated sensitivity to the anticonvulsant phenytoin. Epilepsia. PMID 27375106 DOI: 10.1111/Epi.13461  0.511
2016 Meisler MH, Helman G, Hammer MF, Fureman BE, Gaillard WD, Goldin AL, Hirose S, Ishii A, Kroner BL, Lossin C, Mefford HC, Parent JM, Patel M, Schreiber J, Stewart R, et al. SCN8A encephalopathy: Research progress and prospects. Epilepsia. PMID 27270488 DOI: 10.1111/Epi.13422  0.418
2016 Wagnon JL, Barker BS, Hounshell JA, Haaxma CA, Shealy A, Moss T, Parikh S, Messer RD, Patel MK, Meisler MH. Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy. Annals of Clinical and Translational Neurology. 3: 114-23. PMID 26900580 DOI: 10.1002/Acn3.276  0.332
2013 Hargus NJ, Nigam A, Bertram EH, Patel MK. Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis. Journal of Neurophysiology. 110: 1144-57. PMID 23741036 DOI: 10.1152/Jn.00383.2013  0.434
2011 Hargus NJ, Merrick EC, Nigam A, Kalmar CL, Baheti AR, Bertram EH, Patel MK. Temporal lobe epilepsy induces intrinsic alterations in Na channel gating in layer II medial entorhinal cortex neurons. Neurobiology of Disease. 41: 361-76. PMID 20946956 DOI: 10.1016/J.Nbd.2010.10.004  0.382
2010 Zuliani V, Fantini M, Nigam A, Stables JP, Patel MK, Rivara M. Anticonvulsant activity of 2,4(1H)-diarylimidazoles in mice and rats acute seizure models. Bioorganic & Medicinal Chemistry. 18: 7957-65. PMID 20943396 DOI: 10.1016/j.bmc.2010.09.029  0.332
2009 Jones PJ, Merrick EC, Batts TW, Hargus NJ, Wang Y, Stables JP, Bertram EH, Brown ML, Patel MK. Modulation of sodium channel inactivation gating by a novel lactam: implications for seizure suppression in chronic limbic epilepsy. The Journal of Pharmacology and Experimental Therapeutics. 328: 201-12. PMID 18952887 DOI: 10.1124/Jpet.108.144709  0.491
2007 Jones PJ, Wang Y, Smith MD, Hargus NJ, Eidam HS, White HS, Kapur J, Brown ML, Patel MK. Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity. The Journal of Pharmacology and Experimental Therapeutics. 320: 828-36. PMID 17090703 DOI: 10.1124/Jpet.106.111542  0.407
2001 Fahmi AI, Patel M, Stevens EB, Fowden AL, John JE, Lee K, Pinnock R, Morgan K, Jackson AP, Vandenberg JI. The sodium channel β-subunits SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart Journal of Physiology. 537: 693-700. PMID 11744748 DOI: 10.1111/J.1469-7793.2001.00693.X  0.343
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