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Damian Krysan - Publications

Affiliations: 
School of Arts and Sciences University of Rochester, Rochester, NY 
Area:
Molecular Chemistry, Microbiology Biology, Organic Chemistry
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Beattie SR, Esan T, Zarnowski R, Eix E, Nett JE, Andes DR, Hagen T, Krysan DJ. Novel Keto-Alkyl-Pyridinium Antifungal Molecules Active in Models of Candida albicans Vascular Catheter Infection and Candida auris Skin Colonization. Antimicrobial Agents and Chemotherapy. e0008123. PMID 37097144 DOI: 10.1128/aac.00081-23  0.439
2023 Beattie SR, Krysan DJ. A Dual-Readout High-Throughput Screening Assay for Small Molecules Active Against Aspergillus Fumigatus. Methods in Molecular Biology (Clifton, N.J.). 2658: 35-42. PMID 37024693 DOI: 10.1007/978-1-0716-3155-3_3  0.442
2023 Beattie SR, Esan T, Zarnowski R, Eix E, Nett JE, Andes DR, Hagen T, Krysan DJ. Novel keto-alkyl-pyridinium antifungal molecules active in models of in vivo vascular catheter infection and ex vivo skin colonization. Biorxiv : the Preprint Server For Biology. PMID 36711909 DOI: 10.1101/2023.01.19.524835  0.432
2021 Fu C, Beattie SR, Jezewski AJ, Robbins N, Whitesell L, Krysan DJ, Cowen LE. Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence. Genetics. PMID 34849848 DOI: 10.1093/genetics/iyab164  0.419
2021 Beattie SR, Krysan DJ. A Unique Dual-Readout High-Throughput Screening Assay To Identify Antifungal Compounds with Aspergillus fumigatus. Msphere. 6: e0053921. PMID 34406854 DOI: 10.1128/mSphere.00539-21  0.487
2021 Wakade RS, Huang M, Mitchell AP, Wellington M, Krysan DJ. Intravital Imaging of Candida albicans Identifies Differential and Filamentation Phenotypes for Transcription Factor Deletion Mutants. Msphere. e0043621. PMID 34160243 DOI: 10.1128/mSphere.00436-21  0.306
2020 Beattie SR, Krysan DJ. Antifungal drug screening: thinking outside the box to identify novel antifungal scaffolds. Current Opinion in Microbiology. 57: 1-6. PMID 32339892 DOI: 10.1016/j.mib.2020.03.005  0.465
2020 Beattie SR, Schnicker NJ, Murante T, Kettimuthu K, Williams NS, Gakhar L, Krysan D. Benzothiourea derivates target the secretory pathway of the human fungal pathogen Cryptococcus neoformans. Acs Infectious Diseases. PMID 32070095 DOI: 10.1021/Acsinfecdis.9B00478  0.626
2020 Caplan T, Lorente-Macías Á, Stogios PJ, Evdokimova E, Hyde S, Wellington MA, Liston S, Iyer KR, Puumala E, Shekhar-Guturja T, Robbins N, Savchenko A, Krysan DJ, Whitesell L, Zuercher WJ, et al. Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2. Cell Chemical Biology. PMID 31924499 DOI: 10.1016/J.Chembiol.2019.12.008  0.343
2020 Montoya MC, Beattie S, Alden KM, Krysan DJ. Derivatives of the antimalarial drug mefloquine are broad spectrum antifungal molecules with activity against drug-resistant clinical isolates. Antimicrobial Agents and Chemotherapy. PMID 31907188 DOI: 10.1128/AAC.02331-19  0.406
2019 Huang D, LeBlanc E, Shekhar-Guturja T, Robbins N, Krysan D, Pizarro JC, Whitesell L, Cowen L, Brown LE. Design and synthesis of fungal-selective resorcylate aminopyrazole Hsp90 inhibitors. Journal of Medicinal Chemistry. PMID 31513387 DOI: 10.1021/Acs.Jmedchem.9B00826  0.317
2019 Hai TP, Van AD, Ngan NTT, Nhat LTH, Lan NPH, Van Vinh Chau N, Thwaites GE, Krysan D, Day JN. The combination of tamoxifen with amphotericin B, but not with fluconazole, has synergistic activity against the majority of clinical isolates of Cryptococcus neoformans. Mycoses. PMID 31173410 DOI: 10.1111/Myc.12955  0.349
2018 Montoya MC, Krysan DJ. Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease. Mbio. 9. PMID 30563895 DOI: 10.1128/mBio.02272-18  0.352
2018 O'Meara TR, Duah K, Guo CX, Maxson ME, Gaudet RG, Koselny K, Wellington M, Powers ME, MacAlpine J, O'Meara MJ, Veri AO, Grinstein S, Noble SM, Krysan D, Gray-Owen SD, et al. High-Throughput Screening Identifies Genes Required for Induction of Macrophage Pyroptosis. Mbio. 9. PMID 30131363 DOI: 10.1128/Mbio.01581-18  0.365
2017 Montoya MC, DiDone L, Heier R, Meyers M, Krysan D. Antifungal phenothiazines: optimization, characterization of mechanism and modulation of neuroreceptor activity. Acs Infectious Diseases. PMID 29058407 DOI: 10.1021/acsinfecdis.7b00157  0.364
2016 Koselny K, Green J, DiDone L, Halterman JP, Fothergill AW, Wiederhold NP, Patterson TF, Cushion MT, Rappelye C, Wellington M, Krysan DJ. The celecoxib derivative AR-12 has broad spectrum antifungal activity in vitro and improves the activity of fluconazole in a murine model of cryptococcosis. Antimicrobial Agents and Chemotherapy. PMID 27645246 DOI: 10.1128/Aac.01061-16  0.344
2016 Blanchard C, Brooks L, Ebsworth-Mojica K, Didione L, Wucher B, Dewhurst S, Krysan D, Dunman PM, Wozniak RA. Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment. Msphere. 1. PMID 27642637 DOI: 10.1128/mSphere.00194-16  0.359
2016 Hartland K, Pu J, Palmer M, Dandapani S, Moquist PN, Munoz B, DiDone L, Schreiber SL, Krysan DJ. High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling. Acs Infectious Diseases. 2: 93-102. PMID 26807437 DOI: 10.1021/Acsinfecdis.5B00111  0.343
2015 Forbes L, Ebsworth-Mojica K, DiDone L, Li SG, Freundlich JS, Connell N, Dunman PM, Krysan DJ. A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis. Plos One. 10: e0129234. PMID 26098625 DOI: 10.1371/Journal.Pone.0129234  0.323
2015 Butts A, Martin JA, DiDone L, Bradley EK, Mutz M, Krysan DJ. Structure-activity relationships for the antifungal activity of selective estrogen receptor antagonists related to tamoxifen. Plos One. 10: e0125927. PMID 26016941 DOI: 10.1371/Journal.Pone.0125927  0.606
2015 Krysan DJ. Toward improved anti-cryptococcal drugs: Novel molecules and repurposed drugs. Fungal Genetics and Biology : Fg & B. 78: 93-8. PMID 25514636 DOI: 10.1016/j.fgb.2014.12.001  0.395
2014 Brown JC, Nelson J, VanderSluis B, Deshpande R, Butts A, Kagan S, Polacheck I, Krysan DJ, Myers CL, Madhani HD. Unraveling the biology of a fungal meningitis pathogen using chemical genetics. Cell. 159: 1168-87. PMID 25416953 DOI: 10.1016/J.Cell.2014.10.044  0.596
2014 Perlmutter JI, Forbes LT, Krysan DJ, Ebsworth-Mojica K, Colquhoun JM, Wang JL, Dunman PM, Flaherty DP. Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus. Journal of Medicinal Chemistry. 57: 8540-62. PMID 25238555 DOI: 10.1021/Jm5010682  0.35
2014 Krysan DJ, Sutterwala FS, Wellington M. Catching fire: Candida albicans, macrophages, and pyroptosis. Plos Pathogens. 10: e1004139. PMID 24967821 DOI: 10.1371/Journal.Ppat.1004139  0.308
2014 Roemer T, Krysan DJ. Antifungal drug development: challenges, unmet clinical needs, and new approaches. Cold Spring Harbor Perspectives in Medicine. 4. PMID 24789878 DOI: 10.1101/cshperspect.a019703  0.363
2014 Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, ... Krysan DJ, et al. Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo. Mbio. 5: e00765-13. PMID 24520056 DOI: 10.1128/Mbio.00765-13  0.639
2013 Butts A, DiDone L, Koselny K, Baxter BK, Chabrier-Rosello Y, Wellington M, Krysan DJ. A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis. Eukaryotic Cell. 12: 278-87. PMID 23243064 DOI: 10.1128/Ec.00314-12  0.632
2013 Jacobs AC, Didone L, Jobson J, Sofia MK, Krysan D, Dunman PM. Adenylate kinase release as a high-throughput-screening-compatible reporter of bacterial lysis for identification of antibacterial agents. Antimicrobial Agents and Chemotherapy. 57: 26-36. PMID 23027196 DOI: 10.1128/Aac.01640-12  0.458
2012 Butts A, Krysan DJ. Antifungal drug discovery: something old and something new. Plos Pathogens. 8: e1002870. PMID 22969422 DOI: 10.1371/Journal.Ppat.1002870  0.615
2011 DiDone L, Oga D, Krysan DJ. A novel assay of biofilm antifungal activity reveals that amphotericin B and caspofungin lyse Candida albicans cells in biofilms. Yeast (Chichester, England). 28: 561-8. PMID 21674619 DOI: 10.1002/yea.1860  0.366
2009 Dolan K, Montgomery S, Buchheit B, Didone L, Wellington M, Krysan DJ. Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization. Antimicrobial Agents and Chemotherapy. 53: 3337-46. PMID 19487443 DOI: 10.1128/Aac.01564-08  0.338
2008 Krysan DJ, Didone L. A high-throughput screening assay for small molecules that disrupt yeast cell integrity. Journal of Biomolecular Screening. 13: 657-64. PMID 18626115 DOI: 10.1177/1087057108320713  0.306
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