Ralph E. Durand - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Medical Biophysics

89 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Wouters BG, Skarsgard LD, Gerweck LE, Carabe-Fernandez A, Wong M, Durand RE, Nielson D, Bussiere MR, Wagner M, Biggs P, Paganetti H, Suit HD. Radiobiological intercomparison of the 160 MeV and 230 MeV proton therapy beams at the Harvard Cyclotron Laboratory and at Massachusetts General Hospital. Radiation Research. 183: 174-87. PMID 25587741 DOI: 10.1667/Rr13795.1  0.325
2012 Olive PL, Banáth JP, Durand RE. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay. 1990. Radiation Research. 178: AV35-42. PMID 22870978 DOI: 10.1667/RRAV04.1  0.334
2010 Olive PL, Banuelos CA, Durand RE, Kim JY, Aquino-Parsons C. Endogenous and radiation-induced expression of gammaH2AX in biopsies from patients treated for carcinoma of the uterine cervix. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 94: 82-9. PMID 19903578 DOI: 10.1016/J.Radonc.2009.10.009  0.315
2007 Moiseenko V, Duzenli C, Durand RE. In vitro study of cell survival following dynamic MLC intensity-modulated radiation therapy dose delivery. Medical Physics. 34: 1514-20. PMID 17500482 DOI: 10.1118/1.2712044  0.301
2006 Durand RE, Aquino-Parsons C. The fate of hypoxic (pimonidazole-labelled) cells in human cervix tumours undergoing chemo-radiotherapy. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 80: 138-42. PMID 16916562 DOI: 10.1016/J.Radonc.2006.07.022  0.404
2006 Jankovic B, Aquino-Parsons C, Raleigh JA, Stanbridge EJ, Durand RE, Banath JP, MacPhail SH, Olive PL. Comparison between pimonidazole binding, oxygen electrode measurements, and expression of endogenous hypoxia markers in cancer of the uterine cervix Cytometry Part B - Clinical Cytometry. 70: 45-55. PMID 16456867 DOI: 10.1002/Cyto.B.20086  0.353
2005 Olive PL, Durand RE. Heterogeneity in DNA damage using the comet assay. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 66: 1-8. PMID 15924303 DOI: 10.1002/Cyto.A.20154  0.392
2004 Bennewith KL, Durand RE. Quantifying transient hypoxia in human tumor xenografts by flow cytometry. Cancer Research. 64: 6183-9. PMID 15342403 DOI: 10.1158/0008-5472.Can-04-0289  0.692
2004 Durand RE, Aquino-Parsons C. Predicting response to treatment in human cancers of the uterine cervix: sequential biopsies during external beam radiotherapy. International Journal of Radiation Oncology, Biology, Physics. 58: 555-60. PMID 14751527 DOI: 10.1016/J.Ijrobp.2003.09.066  0.328
2002 Bennewith KL, Raleigh JA, Durand RE. Orally administered pimonidazole to label hypoxic tumor cells. Cancer Research. 62: 6827-30. PMID 12460894  0.666
2002 Olive PL, Banáth JP, Durand RE. The range of oxygenation in SiHa tumor xenografts. Radiation Research. 158: 159-66. PMID 12105985 DOI: 10.1667/0033-7587(2002)158[0159:Troois]2.0.Co;2  0.494
2002 Durand RE. Intermittent blood flow in solid tumours--an under-appreciated source of 'drug resistance'. Cancer Metastasis Reviews. 20: 57-61. PMID 11831648 DOI: 10.1023/A:1013181107707  0.344
2001 Durand RE, Aquino-Parsons C. Clinical relevance of intermittent tumour blood flow. Acta Oncologica. 40: 929-936. PMID 11845957 DOI: 10.1080/02841860152708206  0.318
2001 Bennewith KL, Durand RE. Drug-induced alterations in tumour perfusion yield increases in tumour cell radiosensitivity. British Journal of Cancer. 85: 1577-84. PMID 11720448 DOI: 10.1054/bjoc.2001.2123  0.636
2001 Olive PL, Durand RE, Banáth JP, Johnston PJ. Analysis of DNA damage in individual cells. Methods in Cell Biology. 64: 235-49. PMID 11070842 DOI: 10.1016/S0091-679X(01)64016-0  0.352
2001 Durand RE, Olive PL. Resistance of tumor cells to chemo- and radiotherapy modulated by the three-dimensional architecture of solid tumors and spheroids. Methods in Cell Biology. 64: 211-33. PMID 11070841 DOI: 10.1016/S0091-679X(01)64015-9  0.449
2000 Olive PL, Durand RE, Raleigh JA, Luo C, Aquino-Parsons C. Comparison between the comet assay and pimonidazole binding for measuring tumour hypoxia. British Journal of Cancer. 83: 1525-31. PMID 11076663 DOI: 10.1054/Bjoc.2000.1489  0.414
1999 Olive PL, Durand RE, Jackson SM, Le Riche JC, Luo C, Ma R, McLaren DB, Aquino-Parsons C, Thomson TA, Trotter T. The comet assay in clinical practice. Acta Oncologica (Stockholm, Sweden). 38: 839-44. PMID 10606413 DOI: 10.1080/028418699432527  0.464
1999 Brown RC, Durand RE. Repair, redistribution and repopulation in V79 spheroids during multifraction irradiation. Cell Proliferation. 27: 343-54. PMID 10465022 DOI: 10.1111/j.1365-2184.1994.tb01431.x  0.337
1999 Sham E, Durand RE. Repopulation characteristics and cell kinetic parameters resulting from multi-fraction irradiation of xenograft tumors in SCID mice. International Journal of Radiation Oncology, Biology, Physics. 43: 617-22. PMID 10078647 DOI: 10.1016/S0360-3016(98)00427-1  0.468
1998 Durand RE, Sham E. The lifetime of hypoxic human tumor cells. International Journal of Radiation Oncology, Biology, Physics. 42: 711-5. PMID 9845082 DOI: 10.1016/S0360-3016(98)00305-8  0.457
1998 Huang P, Olive PL, Durand RE. Use of the comet assay for assessment of drug resistance and its modulation in vivo. British Journal of Cancer. 77: 412-6. PMID 9472636 DOI: 10.1038/Bjc.1998.65  0.414
1998 Olive PL, Johnston PJ, Banáth JP, Durand RE. The comet assay: a new method to examine heterogeneity associated with solid tumors. Nature Medicine. 4: 103-5. PMID 9427615 DOI: 10.1038/Nm0198-103  0.331
1997 Durand RE, Olive PL. Physiologic and cytotoxic effects of tirapazamine in tumor-bearing mice. Radiation Oncology Investigations. 5: 213-9. PMID 9372543 DOI: 10.1002/(Sici)1520-6823(1997)5:5<213::Aid-Roi1>3.0.Co;2-0  0.512
1997 Durand RE. Tumor repopulation during radiotheraphy: quantitation in two xenografted human tumors. International Journal of Radiation Oncology, Biology, Physics. 39: 803-8. PMID 9369126 DOI: 10.1016/S0360-3016(97)00460-4  0.398
1997 Olive PL, Banáth JP, Durand RE. Detection of subpopulations resistant to DNA-damaging agents in spheroids and murine tumours. Mutation Research. 375: 157-65. PMID 9202726 DOI: 10.1016/S0027-5107(97)00011-0  0.411
1997 Durand RE, LePard NE. Tumour blood flow influences combined radiation and doxorubicin treatments. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 42: 171-9. PMID 9106927 DOI: 10.1016/S0167-8140(96)01878-6  0.411
1996 Wouters BG, Lam GKY, Oelfke U, Gardey K, Durand RE, Skarsgard LD. Measurements of Relative Biological Effectiveness of the 70 MeV Proton Beam at TRIUMF Using Chinese Hamster V79 Cells and the High-Precision Cell Sorter Assay Radiation Research. 146: 159. DOI: 10.2307/3579588  0.381
1996 Olive PL, Banáth JP, Durand RE, Banath JP. Development of Apoptosis and Polyploidy in Human Lymphoblast Cells as a Function of Position in the Cell Cycle at the Time of Irradiation Radiation Research. 146: 595. DOI: 10.2307/3579374  0.366
1996 Skarsgard LD, Skwarchuk MW, Wouters BG, Durand RE. Substructure in the Radiation Survival Response at Low Dose in Cells of Human Tumor Cell Lines Radiation Research. 146: 388. DOI: 10.2307/3579301  0.435
1995 Durand RE. Contributions of flow cytometry to studies with multicell spheroids. Methods in Cell Biology. 405-22. PMID 7877506 DOI: 10.1016/S0091-679X(08)61087-0  0.376
1995 Durand RE, LePard NE. Contribution of transient blood flow to tumour hypoxia in mice. Acta Oncologica (Stockholm, Sweden). 34: 317-23. PMID 7779416 DOI: 10.3109/02841869509093982  0.413
1994 Olive PL, Vikse CM, Durand RE. Hypoxic fractions measured in murine tumors and normal tissues using the comet assay. International Journal of Radiation Oncology, Biology, Physics. 29: 487-91. PMID 8005804 DOI: 10.1016/0360-3016(94)90443-X  0.42
1994 Durand RE, LePard NE. Modulation of tumor hypoxia by conventional chemotherapeutic agents. International Journal of Radiation Oncology, Biology, Physics. 29: 481-6. PMID 8005803 DOI: 10.1016/0360-3016(94)90442-1  0.391
1994 Olive PL, Durand RE. Drug and radiation resistance in spheroids: cell contact and kinetics. Cancer Metastasis Reviews. 13: 121-38. PMID 7923546 DOI: 10.1007/Bf00689632  0.388
1993 Durand RE. Determining Tpot in heterogeneous systems: a new approach illustrated with multicell spheroids. Cytometry. 14: 527-34. PMID 8354126 DOI: 10.1002/cyto.990140512  0.341
1993 Skarsgard LD, Wilson DJ, Durand RE. Survival at Low Dose in Asynchronous and Partially Synchronized Chinese Hamster V79-171 Cells Radiation Research. 133: 102. DOI: 10.2307/3578263  0.427
1992 Olive PL, Durand RE. Detection of hypoxic cells in a murine tumor with the use of the comet assay. Journal of the National Cancer Institute. 84: 707-11. PMID 1569605 DOI: 10.1093/Jnci/84.9.707  0.471
1992 Durand RE, Olive PL. Evaluation of bioreductive drugs in multicell spheroids. International Journal of Radiation Oncology, Biology, Physics. 22: 689-92. PMID 1544838 DOI: 10.1016/0360-3016(92)90504-B  0.437
1991 Durand RE. Cisplatin and CCNU synergism in spheroid cell subpopulations. British Journal of Cancer. 62: 947-53. PMID 2257225 DOI: 10.1038/bjc.1990.415  0.303
1991 Durand RE, Vanderbyl SL. Schedule dependence for cisplatin and etoposide multifraction treatments of spheroids. Journal of the National Cancer Institute. 82: 1841-5. PMID 2250300 DOI: 10.1093/Jnci/82.23.1841  0.363
1991 Guichard M, Lespinasse F, Trotter M, Durand R, Chaplin D. The effect of hydralazine on blood flow and misonidazole toxicity in human tumour xenografts Radiotherapy and Oncology. 20: 117-123. PMID 2031087 DOI: 10.1016/0167-8140(91)90145-7  0.343
1991 Yan R, Durand RE. The response of hypoxic cells in sccvii murine tumors to treatment with cisplatin and X rays International Journal of Radiation Oncology, Biology, Physics. 20: 271-274. PMID 1991687 DOI: 10.1016/0360-3016(91)90103-B  0.468
1991 Durand RE. Keynote address: the influence of microenvironmental factors on the activity of radiation and drugs. International Journal of Radiation Oncology, Biology, Physics. 20: 253-8. PMID 1991686 DOI: 10.1016/0360-3016(91)90100-I  0.471
1991 Durand RE, Chaplin DJ, Olive PL. Cell sorting with Hoechst or carbocyanine dyes as perfusion probes in spheroids and tumors. Methods in Cell Biology. 33: 509-18. PMID 1707493 DOI: 10.1016/S0091-679X(08)60550-6  0.466
1991 Skarsgard LD, Harrison I, Durand RE. The Radiation Response of Asynchronous Cells at Low Dose: Evidence of Substructure Radiation Research. 127: 248. DOI: 10.2307/3577938  0.405
1990 Durand RE, Vanderbyl SL. Tumor resistance to therapy: a genetic or kinetic problem? Cancer Communications. 1: 277-83. PMID 2702035 DOI: 10.3727/095535489820874869  0.332
1990 Minchinton AI, Durand RE, Chaplin DJ. Intermittent blood flow in the KHT sarcoma--flow cytometry studies using Hoechst 33342. British Journal of Cancer. 62: 195-200. PMID 2386734 DOI: 10.1038/Bjc.1990.259  0.443
1990 Durand RE. Slow penetration of anthracyclines into spheroids and tumors: a therapeutic advantage? Cancer Chemotherapy and Pharmacology. 26: 198-204. PMID 2357767 DOI: 10.1007/BF02897199  0.373
1990 Olive PL, Banáth JP, Durand RE. Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells. Journal of the National Cancer Institute. 82: 779-83. PMID 2325148 DOI: 10.1093/Jnci/82.9.779  0.399
1990 Fengler JJ, Durand RE. Respiration-induced oxygen gradients in cultured mammalian cells. International Journal of Radiation Biology. 58: 133-44. PMID 1973431 DOI: 10.1080/09553009014551491  0.306
1990 Olive PL, Banáth JP, Durand RE. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the comet assay Radiation Research. 122: 86-94. DOI: 10.2307/3577587  0.469
1989 Olive PL, Durand RE. Misonidazole binding in SCCVII tumors in relation to the tumor blood supply. International Journal of Radiation Oncology, Biology, Physics. 16: 755-61. PMID 2921174 DOI: 10.1016/0360-3016(89)90495-1  0.387
1989 Durand RE. Distribution and activity of antineoplastic drugs in a tumor model. Journal of the National Cancer Institute. 81: 146-52. PMID 2909755 DOI: 10.1093/jnci/81.2.146  0.326
1989 Durand RE, Vanderbyl SL. Sequencing radiation and adriamycin exposures in spheroids to maximize therapeutic gain. International Journal of Radiation Oncology, Biology, Physics. 17: 345-50. PMID 2753758 DOI: 10.1016/0360-3016(89)90449-5  0.422
1989 Trotter MJ, Chaplin DJ, Durand RE, Olive PL. The use of fluorescent probes to identify regions of transient perfusion in murine tumors. International Journal of Radiation Oncology, Biology, Physics. 16: 931-4. PMID 2703399 DOI: 10.1016/0360-3016(89)90889-4  0.407
1989 Durand RE. Synergism of cisplatin and mitomycin C in sensitive and resistant cell subpopulations of a tumor model. International Journal of Cancer. 44: 911-7. PMID 2511158 DOI: 10.1002/ijc.2910440528  0.34
1988 Durand RE. Repair and proliferation: major determinants of the multifraction radiation response. International Journal of Radiation Oncology, Biology, Physics. 15: 1147-52. PMID 3182347 DOI: 10.1016/0360-3016(88)90197-6  0.358
1987 Durand RE, Chaplin DJ. Chemosensitization by misonidazole in CCNU-treated spheroids and tumours British Journal of Cancer. 56: 103-109. PMID 3663461 DOI: 10.1038/bjc.1987.165  0.316
1987 Rasey JS, Grunbaum Z, Magee S, Nelson NJ, Olive PL, Durand RE, Krohn KA. Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells Radiation Research. 111: 292-304. PMID 3628717 DOI: 10.2307/3576986  0.313
1987 Olive PL, Durand RE, Chaplin DJ. Cytotoxicity of RSU 1069 in spheroids and murine tumors. International Journal of Radiation Oncology, Biology, Physics. 13: 1361-6. PMID 3624045 DOI: 10.1016/0360-3016(87)90230-6  0.492
1987 Jorgensen TJ, Olive PL, Durand RE. DNA strand breakage in Chinese hamster V79 cells caused by low levels of incorporated [3H] and [14C]thymidine. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 51: 673-80. PMID 3495511 DOI: 10.1080/09553008414552201  0.337
1986 Durand RE, Olive PL. Potentiation of CCNU toxicity by AF-2 in V79 spheroids: implications for mechanisms of chemosensitization. International Journal of Radiation Oncology, Biology, Physics. 12: 1375-8. PMID 3759558 DOI: 10.1016/0360-3016(86)90175-6  0.375
1986 Chaplin DJ, Durand RE, Olive PL. Acute hypoxia in tumors: implications for modifiers of radiation effects. International Journal of Radiation Oncology, Biology, Physics. 12: 1279-82. PMID 3759546 DOI: 10.1016/0360-3016(86)90153-7  0.505
1986 Chaplin DJ, Durand RE, Stratford IJ, Jenkins TC. The radiosensitizing and toxic effects of RSU-1069 on hypoxic cells in a murine tumor. International Journal of Radiation Oncology, Biology, Physics. 12: 1091-5. PMID 3755714 DOI: 10.1016/0360-3016(86)90233-6  0.384
1986 Skarsgard LD, Harrison I, Durand RE, Palcic B. Radiosensitization of hypoxic cells at low doses. International Journal of Radiation Oncology, Biology, Physics. 12: 1075-8. PMID 2943706 DOI: 10.1016/0360-3016(86)90229-4  0.401
1985 Biaglow JE, Suit HD, Durand RE, Dosoretz DE. On the mechanism for enhancement of tumor radiation to hyperbaric oxygen in sodium pentobarbital anesthetized rodents. Advances in Experimental Medicine and Biology. 180: 301-10. PMID 6534107 DOI: 10.1007/978-1-4684-4895-5_29  0.393
1985 Sutherland RM, Durand RE. Growth and cellular characteristics of multicell spheroids. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer. 95: 24-49. PMID 6396760 DOI: 10.1007/978-3-642-82340-4_2  0.314
1985 Olive PL, Chaplin DJ, Durand RE. Pharmacokinetics, binding and distribution of Hoechst 33342 in spheroids and murine tumours. British Journal of Cancer. 52: 739-46. PMID 4063148 DOI: 10.1038/Bjc.1985.252  0.429
1985 Chaplin DJ, Durand RE, Olive PL. Cell selection from a murine tumour using the fluorescent probe Hoechst 33342. British Journal of Cancer. 51: 569-72. PMID 2579667 DOI: 10.1038/Bjc.1985.79  0.327
1985 Olive PL, Durand RE. Effect of Intercellular Contact on DNA Conformation, Radiation-Induced DNA Damage, and Mutation in Chinese Hamster V79 Cells Radiation Research. 101: 94. DOI: 10.2307/3576306  0.363
1984 Spiro IJ, Rice GC, Durand RE, Stickler R, Ling CC. Cell killing, radiosensitization and cell cycle redistribution induced by chronic hypoxia. International Journal of Radiation Oncology, Biology, Physics. 10: 1275-80. PMID 6469750 DOI: 10.1016/0360-3016(84)90332-8  0.341
1984 Sutherland R, Carlsson J, Durand R, Yuhas J. Spheroids in Cancer Research Cancer Research. 41: 2980-2984. DOI: 10.1007/978-3-642-82340-4  0.38
1983 Durand RE. Cellular oxygen utilization and radiation response of V-79 spheroids. Advances in Experimental Medicine and Biology. 159: 419-34. PMID 6356808 DOI: 10.1007/978-1-4684-7790-0_36  0.349
1983 Durand RE. Radioprotection by WR-2721 in vitro at low oxygen tensions: implications for its mechanisms of action. British Journal of Cancer. 47: 387-92. PMID 6299319 DOI: 10.1038/bjc.1983.58  0.306
1983 Durand RE. Oxygen Enhancement Ratio in V79 Spheroids Radiation Research. 96: 322. DOI: 10.2307/3576215  0.438
1983 Durand RE, Olive PL. Flow Cytometry Techniques for Studying Cellular Thiols Radiation Research. 95: 456. DOI: 10.2307/3576093  0.325
1982 Durand RE, Brown SM. Combination adriamycin/misonidazole toxicity in V79 spheroids International Journal of Radiation Oncology, Biology, Physics. 8: 603-605. PMID 7107380 DOI: 10.1016/0360-3016(82)90693-9  0.356
1982 Durand RE, Olive PL. Cytotoxicity, Mutagenicity and DNA damage by Hoechst 33342. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 30: 111-6. PMID 7061816 DOI: 10.1177/30.2.7061816  0.403
1982 Durand RE. Use of Hoechst 33342 for cell selection from multicell systems. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 30: 117-22. PMID 6174559 DOI: 10.1177/30.2.6174559  0.393
1978 Biaglow JE, Durand RE. The enhanced radiation response of an in vitro tumour model by cyanide released from hydrolysed amygdalin. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 33: 397-401. PMID 417038 DOI: 10.1080/09553007814550311  0.305
1978 Durand RE. Effects of Hyperthermia on the Cycling, Noncycling, and Hypoxic Cells of Irradiated and Unirradiated Multicell Spheroids Radiation Research. 75: 373. DOI: 10.2307/3574911  0.432
1977 Durand RE, Olive PL. Fast neutron effects on multicell spheroids. The British Journal of Radiology. 50: 423-9. PMID 871588 DOI: 10.1259/0007-1285-50-594-423  0.303
1977 Durand RE, Biaglow JE. Radiosensitization of Hypoxic Cells of an in Vitro Tumor Model by Respiratory Inhibitors Radiation Research. 69: 359. DOI: 10.2307/3574443  0.479
1976 Durand RE. Adriamycin: a possible indirect radiosensitizer of hypoxic tumor cells. Radiology. 119: 217-22. PMID 1257446 DOI: 10.1148/119.1.217  0.42
1976 Durand RE. Cell cycle kinetics in an in vitro tumor model. Cell and Tissue Kinetics. 9: 403-12. PMID 975203 DOI: 10.1111/j.1365-2184.1976.tb01290.x  0.333
1976 Biaglow JE, Durand RE. The Effects of Nitrobenzene Derivatives on Oxygen Utilization and Radiation Response of an in Vitro Tumor Model Radiation Research. 65: 529. DOI: 10.2307/3574384  0.42
1975 Durand RE. Cure, regression and cell survival: a comparison of common radiobiological endpoints using an in vitro tumour model. The British Journal of Radiology. 48: 556-71. PMID 1148588 DOI: 10.1259/0007-1285-48-571-556  0.38
1972 Sutherland RM, Durand RE. Cell contact as a possible contribution to radiation resistance of some tumours. The British Journal of Radiology. 45: 788-9. PMID 4672981 DOI: 10.1259/0007-1285-45-538-788  0.419
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